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Aliases for TXLNB Gene

Aliases for TXLNB Gene

  • Taxilin Beta 2 3
  • Muscle-Derived Protein 77 3 4
  • C6orf198 3 4
  • MDP77 3 4
  • Chromosome 6 Open Reading Frame 198 2
  • Beta-Taxilin 3
  • DJ522B19.2 3
  • LST001 3
  • HMDP77 4

External Ids for TXLNB Gene

Previous HGNC Symbols for TXLNB Gene

  • C6orf198

Previous GeneCards Identifiers for TXLNB Gene

  • GC06M139603
  • GC06M137122

Summaries for TXLNB Gene

GeneCards Summary for TXLNB Gene

TXLNB (Taxilin Beta) is a Protein Coding gene. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is TXLNA.

UniProtKB/Swiss-Prot for TXLNB Gene

  • Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.

Gene Wiki entry for TXLNB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNB Gene

Genomics for TXLNB Gene

Regulatory Elements for TXLNB Gene

Genomic Location for TXLNB Gene

139,240,061 bp from pter
139,324,011 bp from pter
83,951 bases
Minus strand

Genomic View for TXLNB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXLNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNB Gene

Proteins for TXLNB Gene

  • Protein details for TXLNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5VTF3
    • Q76L25
    • Q86T52
    • Q8N3S2

    Protein attributes for TXLNB Gene

    684 amino acids
    Molecular mass:
    76519 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A
    • Sequence=CAD38924.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD91140.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXLNB Gene

Proteomics data for TXLNB Gene at MOPED

Post-translational modifications for TXLNB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXLNB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TXLNB Gene

Domains for TXLNB Gene

Protein Domains for TXLNB Gene


Suggested Antigen Peptide Sequences for TXLNB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the taxilin family.
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNB: view

No data available for Gene Families for TXLNB Gene

Function for TXLNB Gene

Molecular function for TXLNB Gene

UniProtKB/Swiss-Prot Function:
Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.

Gene Ontology (GO) - Molecular Function for TXLNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with TXLNB: view

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXLNB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TXLNB Gene

Localization for TXLNB Gene

Subcellular locations from

Jensen Localization Image for TXLNB Gene COMPARTMENTS Subcellular localization image for TXLNB gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TXLNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TXLNB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TXLNB Gene

Pathways for TXLNB Gene

SuperPathways for TXLNB Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXLNB Gene


No data available for Pathways by source for TXLNB Gene

Transcripts for TXLNB Gene

Unigene Clusters for TXLNB Gene

Taxilin beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXLNB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNB Gene

No ASD Table

Relevant External Links for TXLNB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXLNB Gene

mRNA expression in normal human tissues for TXLNB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXLNB Gene

This gene is overexpressed in Muscle - Skeletal (28.4), Heart - Left Ventricle (10.2), and Heart - Atrial Appendage (5.8).

Protein differential expression in normal tissues for TXLNB Gene

This gene is overexpressed in Testis (37.6), Heart (14.6), Ovary (8.0), and Fetal heart (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TXLNB Gene

SOURCE GeneReport for Unigene cluster for TXLNB Gene Hs.535820

mRNA Expression by UniProt/SwissProt for TXLNB Gene

Tissue specificity: Expressed in skeletal muscle
genes like me logo Genes that share expressions with TXLNB: view

Expression partners for TXLNB Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for TXLNB Gene

This gene was present in the common ancestor of animals.

Orthologs for TXLNB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TXLNB 35
  • 83.04 (n)
  • 78.11 (a)
  • 71 (a)
(Canis familiaris)
Mammalia TXLNB 35
  • 84.92 (n)
  • 81.5 (a)
  • 81 (a)
(Mus musculus)
Mammalia Txlnb 35
  • 77.07 (n)
  • 73.08 (a)
Txlnb 16
Txlnb 36
  • 71 (a)
(Pan troglodytes)
Mammalia TXLNB 35
  • 99.17 (n)
  • 98.25 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Txlnb 35
  • 77.48 (n)
  • 74.4 (a)
(Monodelphis domestica)
Mammalia TXLNB 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia TXLNB 36
  • 57 (a)
(Gallus gallus)
Aves TXLNB 35
  • 70.53 (n)
  • 72.01 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia TXLNB 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txlnb 35
  • 69.52 (n)
  • 70.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2928 35
(Danio rerio)
Actinopterygii txlnba 36
  • 35 (a)
txlnbb 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea T22C1.6 36
  • 30 (a)
Species with no ortholog for TXLNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNB Gene

Gene Tree for TXLNB (if available)
Gene Tree for TXLNB (if available)

Paralogs for TXLNB Gene

Paralogs for TXLNB Gene

(5) SIMAP similar genes for TXLNB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TXLNB: view

Variants for TXLNB Gene

Sequence variations from dbSNP and Humsavar for TXLNB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs726794 -- 139,268,908(+) TCTCT(C/T)TCTTT intron-variant
rs943650 -- 139,257,572(+) CAGCA(C/T)GCTGT intron-variant
rs943651 -- 139,257,872(+) AAATG(G/T)GTTGC intron-variant
rs1887554 -- 139,239,566(+) TGGCT(C/T)ACTGC downstream-variant-500B
rs1887555 -- 139,242,037(+) catac(A/G)tgtat utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TXLNB Gene

Variant ID Type Subtype PubMed ID
nsv508433 CNV Loss 20534489
esv2670136 CNV Deletion 23128226
dgv1155e199 CNV Deletion 23128226
nsv5501 CNV Loss 18451855
nsv511917 CNV Loss 21212237
esv33633 CNV Loss 17666407
esv2223307 CNV Deletion 18987734
nsv821147 CNV Deletion 20802225
nsv823848 CNV Loss 20364138
dgv1066e201 CNV Deletion 23290073
dgv1067e201 CNV Deletion 23290073
esv29795 CNV Gain 19812545
esv2667716 CNV Deletion 23128226
nsv819805 CNV Gain 19587683
nsv511325 CNV Loss 21212237
nsv499774 CNV Loss 21111241
nsv823849 CNV Gain 20364138
esv2421923 CNV Deletion 20811451
nsv514391 CNV Loss 21397061

Relevant External Links for TXLNB Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNB Gene

Disorders for TXLNB Gene

Relevant External Links for TXLNB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for TXLNB Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TXLNB Gene

Publications for TXLNB Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats. (PMID: 15082161) Itoh S. … Taguchi T. (Neurosci. Lett. 2004) 3 4

Products for TXLNB Gene

Sources for TXLNB Gene

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