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TXLNB Gene

protein-coding   GIFtS: 50
GCID: GC06M139603

Taxilin Beta

(Previous name: chromosome 6 open reading frame 198)
(Previous symbol: C6orf198)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taxilin Beta1 2     LST0012
C6orf1981 2 3     beta-taxilin2
Muscle-Derived Protein 772 3     dJ522B19.22
MDP772 3     hMDP773
Chromosome 6 Open Reading Frame 1981     

External Ids:    HGNC: 216171   Entrez Gene: 1678382   Ensembl: ENSG000001644407   OMIM: 6114385   UniProtKB: Q8N3L33   

Export aliases for TXLNB gene to outside databases

Previous GC identifer: GC06M137122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXLNB Gene:
TXLNB (taxilin beta) is a protein-coding gene. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is TXLNA.

UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3
Function: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic

Gene Wiki entry for TXLNB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXLNB gene promoter:
         FOXF2   C/EBPalpha   MEF-2A   POU2F1   POU2F1a   POU2F1b   aMEF-2   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXLNB promoter sequence
   Search Chromatin IP Primers for TXLNB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXLNB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24.1   Ensembl cytogenetic band:  6q24.1   HGNC cytogenetic band: 6q23.3

TXLNB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXLNB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M139603:  view genomic region     (about GC identifiers)

Start:
139,561,198 bp from pter      End:
139,613,276 bp from pter
Size:
52,079 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3 (See protein sequence)
Recommended Name: Beta-taxilin  
Size: 684 amino acids; 76519 Da
Subunit: Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a
preference for STX1A
Sequence caution: Sequence=CAD38924.2; Type=Erroneous initiation; Sequence=CAD91140.1; Type=Erroneous initiation;
Secondary accessions: Q5VTF3 Q76L25 Q86T52 Q8N3S2

Explore the universe of human proteins at neXtProt for TXLNB: NX_Q8N3L3

Explore proteomics data for TXLNB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TXLNB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_694967.3  
    ENSEMBL proteins: 
     ENSP00000351206   ENSP00000356624  

    TXLNB Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026183 Taxilin_fam

    Graphical View of Domain Structure for InterPro Entry Q8N3L3

    ProtoNet protein and cluster: Q8N3L3

    UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3
    Similarity: Belongs to the taxilin family


    Find genes that share domains with TXLNB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXLNB_HUMAN, Q8N3L3
    Function: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0019905syntaxin binding IEA--
         
    Find genes that share ontologies with TXLNB           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXLNB
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TXLNB (see all 32):
    hsa-miR-2052 hsa-miR-607 hsa-miR-19b-2* hsa-miR-374a hsa-miR-183* hsa-miR-647 hsa-miR-934 hsa-miR-409-3p
    SwitchGear 3'UTR luciferase reporter plasmidTXLNB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TXLNB

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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with TXLNB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXLNB
    Interactions:

        Search GeneGlobe Interaction Network for TXLNB

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for TXLNB (Q8N3L31, 3 ENSP000003512064) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TXLNAP402221, 3, ENSP000003627114EBI-6116822,EBI-359793 I2D: score=1 STRING: ENSP00000362711
    STX4Q128463, ENSP000003177144I2D: score=2 STRING: ENSP00000317714
    TXLNGQ9NUQ33, ENSP000003694654I2D: score=1 STRING: ENSP00000369465
    STX1AQ166233, ENSP000002228124I2D: score=2 STRING: ENSP00000222812
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXLNB



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TXLNB gene: 
    NM_153235.3  

    Unigene Cluster for TXLNB:

    Taxilin beta
    Hs.535820  [show with all ESTs]
    Unigene Representative Sequence: NM_153235
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358430(uc021zfy.1) ENST00000367652
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TXLNB (see all 32):
    hsa-miR-2052 hsa-miR-607 hsa-miR-19b-2* hsa-miR-374a hsa-miR-183* hsa-miR-647 hsa-miR-934 hsa-miR-409-3p
    SwitchGear 3'UTR luciferase reporter plasmidTXLNB 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TXLNB
      QuantiFast Probe-based Assays in human, mouse, rat TXLNB

    Additional mRNA sequence: 

    AB085905.1 AF111704.1 AK056970.1 AK314725.1 AL831988.1 AL832322.1 AL834248.2 BC115383.1 
    BC115384.2 BX647477.1 BX647633.1 

    7 DOTS entries:

    DT.99951056  DT.309367  DT.86857086  DT.121340460  DT.100749620  DT.121340367  DT.203905 

    Selected AceView cDNA sequences (see all 41):

    AA918450 AI589117 BX500133 AB085905 AF111704 CB054121 AA233930 AL589616 
    BX501036 AI015340 AL831988 AL589618 CD359961 AA580070 BX647477 AI039795 
    CB054122 AL834248 BX101595 BF576885 AW074101 AL589617 AL832322 AI276991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXLNB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATATCTTGG
    TXLNB Expression
    About this image


    TXLNB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Heart (Cardiovascular System)
     
     Skeletal Muscle (Muscoskeletal System)
    TXLNB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXLNB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535820

    UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3
    Tissue specificity: Expressed in skeletal muscle

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TXLNB gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txlnb1 , 5 taxilin beta1, 5 77.07(n)1
    73.08(a)1
      10 (7.24 cM)5
    3784311  NM_138628.31  NP_619534.21 
     177962265 
    chicken
    (Gallus gallus)
    Aves TXLNB1 taxilin beta 70.53(n)
    72.01(a)
      395515  NM_204754.1  NP_990085.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXLNB6
    taxilin beta
    61(a)
    1 ↔ 1
    GL343200.1(841804-872278)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia txlnb1 taxilin beta 69.52(n)
    70.55(a)
      100495851  XM_002936957.2  XP_002937003.2 
    zebrafish
    (Danio rerio)
    Actinopterygii txlnbb6
    txlnba6
    taxilin beta a
    47(a)
    35(a)
    1 ↔ many
    1 ↔ many
    17(6121994-6146226) ENSDARG00000076241
    20(36870395-36911873) ENSDARG00000020594
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58866
    --
    26(a)
    1 → many
    3R(21677376-21679727)
    worm
    (Caenorhabditis elegans)
    Secernentea T22C1.66
    Protein T22C1.6 (T22C1.6) mRNA, complete cds
    30(a)
    1 → many
    I(7942719-7945588) WBGene00011917


    ENSEMBL Gene Tree for TXLNB (if available)
    TreeFam Gene Tree for TXLNB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXLNB gene
    TXLNA2  TXLNG2  
    5 SIMAP similar genes for TXLNB using alignment to 4 protein entries:     TXLNB_HUMAN (see all proteins):
    DKFZp451B226    DKFZp451H216    TXLNA    TXLNG    CYorf15B

    Find genes that share paralogs with TXLNB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXLNB (see all 1234)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18875541,2
    C--139560703(+) TGGCTC/TACTGC 1 -- ds50010--------
    rs729888991,2
    C,F--139560803(+) TTTTTT/AAAAAC 1 -- ds50012Minor allele frequency- A:0.13NA EA 240
    rs605814371,2
    C,F--139560808(+) TAAAAC/AATTTT 1 -- ds50013Minor allele frequency- A:0.12WA NA EA 358
    rs1915642731,2
    --139560823(+) AGAGAC/TGGGGG 1 -- ds50010--------
    rs1840460841,2
    --139560858(+) TTGAAC/TTCCCA 1 -- ds50010--------
    rs1438314131,2
    --139560876(+) GTGATA/CCTCCC 1 -- ds50010--------
    rs1888791811,2
    --139560907(+) GGGATA/TATAGG 1 -- ds50010--------
    rs1922184471,2
    --139560913(+) ATAGGC/TGTCAG 1 -- ds50010--------
    rs1120899201,2
    C,F--139560956(+) TAGCCC/TCATTG 1 -- ds50012Minor allele frequency- T:0.00CSA 2
    rs580448371,2
    C,F--139560978(+) TCCCTT/CTCTCT 1 -- ds50013Minor allele frequency- C:0.42WA CSA 121

    HapMap Linkage Disequilibrium report for TXLNB (139561198 - 139613276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TXLNB (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2223307CNV Deletion18987734
    nsv821147CNV Deletion20802225
    esv2667716CNV Deletion23128226
    dgv1155e199CNV Deletion23128226
    esv2421923CNV Deletion20811451
    dgv1066e201CNV Deletion23290073
    dgv1067e201CNV Deletion23290073
    esv2670136CNV Deletion23128226
    nsv508433CNV Loss20534489
    nsv511917CNV Loss21212237

    Human Gene Mutation Database (HGMD): TXLNB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXLNB
    DNA2.0 Custom Variant and Variant Library Synthesis for TXLNB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611438    OMIM disorders: --


    Find genes that share disorders with TXLNB           About GenesLikeMe

    Genetic Association Database (GAD): TXLNB
    Human Genome Epidemiology (HuGE) Navigator: TXLNB (1 document)

    Export disorders for TXLNB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXLNB gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TXLNB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of taxilin isoforms. (PubMed id 15184072)1, 2, 3 Nogami S.... Shirataki H. (Biochem. Biophys. Res. Commun. 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats. (PubMed id 15082161)1, 2 Itoh S.... Taguchi T. (Neurosci. Lett. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    7. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (Nucleic Acids Res. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 167838 HGNC: 21617 AceView: C6orf198 Ensembl:ENSG00000164440 euGenes: HUgn167838
    ECgene: TXLNB H-InvDB: TXLNB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TXLNB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TXLNB gene:
    Search GeneIP for patents involving TXLNB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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