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Aliases for TXLNB Gene

Aliases for TXLNB Gene

  • Taxilin Beta 2 3 5
  • Muscle-Derived Protein 77 3 4
  • C6orf198 3 4
  • MDP77 3 4
  • Chromosome 6 Open Reading Frame 198 2
  • DJ522B19.2 3
  • LST001 3
  • HMDP77 4

External Ids for TXLNB Gene

Previous HGNC Symbols for TXLNB Gene

  • C6orf198

Previous GeneCards Identifiers for TXLNB Gene

  • GC06M139603
  • GC06M137122

Summaries for TXLNB Gene

GeneCards Summary for TXLNB Gene

TXLNB (Taxilin Beta) is a Protein Coding gene. Diseases associated with TXLNB include Myotonic Disease and Myotonic Dystrophy 1. GO annotations related to this gene include syntaxin binding. An important paralog of this gene is TXLNA.

UniProtKB/Swiss-Prot for TXLNB Gene

  • Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.

Gene Wiki entry for TXLNB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNB Gene

Genomics for TXLNB Gene

Regulatory Elements for TXLNB Gene

Enhancers for TXLNB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TXLNB on UCSC Golden Path with GeneCards custom track

Genomic Location for TXLNB Gene

139,159,160 bp from pter
139,324,011 bp from pter
164,852 bases
Minus strand

Genomic View for TXLNB Gene

Genes around TXLNB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXLNB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXLNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNB Gene

Proteins for TXLNB Gene

  • Protein details for TXLNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5VTF3
    • Q76L25
    • Q86T52
    • Q8N3S2

    Protein attributes for TXLNB Gene

    684 amino acids
    Molecular mass:
    76519 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preference for STX1A.
    • Sequence=CAD38924.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD91140.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXLNB Gene

Proteomics data for TXLNB Gene at MOPED

Post-translational modifications for TXLNB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXLNB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TXLNB Gene

Domains & Families for TXLNB Gene

Protein Domains for TXLNB Gene


Suggested Antigen Peptide Sequences for TXLNB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the taxilin family.
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNB: view

No data available for Gene Families for TXLNB Gene

Function for TXLNB Gene

Molecular function for TXLNB Gene

UniProtKB/Swiss-Prot Function:
Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic.

Gene Ontology (GO) - Molecular Function for TXLNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019905 syntaxin binding IEA --
genes like me logo Genes that share ontologies with TXLNB: view
genes like me logo Genes that share phenotypes with TXLNB: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXLNB Gene

Localization for TXLNB Gene

Subcellular locations from

Jensen Localization Image for TXLNB Gene COMPARTMENTS Subcellular localization image for TXLNB gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TXLNB Gene

Pathways & Interactions for TXLNB Gene

SuperPathways for TXLNB Gene

No Data Available

Gene Ontology (GO) - Biological Process for TXLNB Gene


No data available for Pathways by source and SIGNOR curated interactions for TXLNB Gene

Drugs & Compounds for TXLNB Gene

No Compound Related Data Available

Transcripts for TXLNB Gene

Unigene Clusters for TXLNB Gene

Taxilin beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNB Gene

No ASD Table

Relevant External Links for TXLNB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TXLNB Gene

mRNA expression in normal human tissues for TXLNB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXLNB Gene

This gene is overexpressed in Muscle - Skeletal (x28.4), Heart - Left Ventricle (x10.2), and Heart - Atrial Appendage (x5.8).

Protein differential expression in normal tissues from HIPED for TXLNB Gene

This gene is overexpressed in Testis (37.6), Heart (14.6), Ovary (8.0), and Fetal heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TXLNB Gene

SOURCE GeneReport for Unigene cluster for TXLNB Gene Hs.535820

mRNA Expression by UniProt/SwissProt for TXLNB Gene

Tissue specificity: Expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with TXLNB: view

Protein tissue co-expression partners for TXLNB Gene

Primer Products

Orthologs for TXLNB Gene

This gene was present in the common ancestor of animals.

Orthologs for TXLNB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TXLNB 35
  • 83.04 (n)
  • 78.11 (a)
  • 71 (a)
(Canis familiaris)
Mammalia TXLNB 35
  • 84.92 (n)
  • 81.5 (a)
  • 81 (a)
(Mus musculus)
Mammalia Txlnb 35
  • 77.07 (n)
  • 73.08 (a)
Txlnb 16
Txlnb 36
  • 71 (a)
(Pan troglodytes)
Mammalia TXLNB 35
  • 99.17 (n)
  • 98.25 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Txlnb 35
  • 77.48 (n)
  • 74.4 (a)
(Monodelphis domestica)
Mammalia TXLNB 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia TXLNB 36
  • 57 (a)
(Gallus gallus)
Aves TXLNB 35
  • 70.53 (n)
  • 72.01 (a)
  • 55 (a)
(Anolis carolinensis)
Reptilia TXLNB 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia txlnb 35
  • 69.52 (n)
  • 70.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2928 35
(Danio rerio)
Actinopterygii txlnba 36
  • 35 (a)
txlnbb 36
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea T22C1.6 36
  • 30 (a)
Species with no ortholog for TXLNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNB Gene

Gene Tree for TXLNB (if available)
Gene Tree for TXLNB (if available)

Paralogs for TXLNB Gene

Paralogs for TXLNB Gene

(5) SIMAP similar genes for TXLNB Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TXLNB: view

Variants for TXLNB Gene

Sequence variations from dbSNP and Humsavar for TXLNB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_019807 -
VAR_057729 -
rs9495392 - 139,243,001(+) TGCCT(A/G)TTTCG intron-variant, reference, missense
rs9495391 - 139,242,777(+) GGACG(C/G)CTGAT intron-variant, reference, missense
rs4992241 -- 139,193,824(+) AATTT(A/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXLNB Gene

Variant ID Type Subtype PubMed ID
nsv508433 CNV Loss 20534489
esv2670136 CNV Deletion 23128226
dgv1155e199 CNV Deletion 23128226
nsv5501 CNV Loss 18451855
nsv511917 CNV Loss 21212237
esv33633 CNV Loss 17666407
esv2223307 CNV Deletion 18987734
nsv821147 CNV Deletion 20802225
nsv823848 CNV Loss 20364138
dgv1066e201 CNV Deletion 23290073
dgv1067e201 CNV Deletion 23290073
esv29795 CNV Gain 19812545
esv2667716 CNV Deletion 23128226
nsv819805 CNV Gain 19587683
nsv511325 CNV Loss 21212237
nsv499774 CNV Loss 21111241
nsv823849 CNV Gain 20364138
esv2421923 CNV Deletion 20811451
nsv514391 CNV Loss 21397061

Variation tolerance for TXLNB Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.55; 92.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXLNB Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNB Gene

Disorders for TXLNB Gene

MalaCards: The human disease database

(2) MalaCards diseases for TXLNB Gene - From: DISEASES

Disorder Aliases PubMed IDs
myotonic disease
  • myotonic disorders
myotonic dystrophy 1
  • major affective disorder 1
- elite association - COSMIC cancer census association via MalaCards
Search TXLNB in MalaCards View complete list of genes associated with diseases

Relevant External Links for TXLNB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TXLNB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXLNB Gene

Publications for TXLNB Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. CBFI^ stabilizes HIV Vif to counteract APOBEC3 at the expense of RUNX1 target gene expression. (PMID: 23333304) Kim D.Y. … Gross J.D. (Mol. Cell 2013) 3

Products for TXLNB Gene

Sources for TXLNB Gene