TXLNB Gene
protein-coding GIFtS: 46
GCID: GC06M139603
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taxilin beta(Previous name: chromosome 6 open reading frame 198 )
(Previous symbol: C6orf198)
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Aliases
for TXLNB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Taxilin Beta1 2 | | DKFZp451A1751 | | C6orf1981 2 3 | | Chromosome 6 Open Reading Frame 1981 | | MDP771 2 3 | | LST0012 | | DJ522B19.21 | | Beta-Taxilin1 | | Muscle-Derived Protein 772 3 | | HMDP771 |
Export aliases for TXLNB gene to outside databasesPrevious GC identifer: GC06M137122 |
Summaries
for TXLNB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3Function: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic
Gene Wiki entry for TXLNB
|
Genomic Views
for TXLNB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TXLNB gene promoter:
FOXF2 C/EBPalpha MEF-2A POU2F1 POU2F1a POU2F1b aMEF-2 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for TXLNB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXLNB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24.1 Ensembl cytogenetic band: 6q24.1 HGNC cytogenetic band: 6q23.3TXLNB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M139603: view genomic region
(about GC identifiers)
Start:
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139,561,198 bp from pter |
End:
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139,613,276 bp from pter |
Size:
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52,079 bases |
Orientation:
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minus strand |
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Proteins
for TXLNB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3 (See
protein sequence)Recommended Name: Beta-taxilin Size: 684 amino acids; 76519 Da
Subunit: Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A. Has a preferencefor STX1A
Sequence caution: Sequence=CAD38924.2; Type=Erroneous initiation; Sequence=CAD91140.1; Type=Erroneous initiation;
Secondary accessions: Q5VTF3 Q76L25 Q86T52 Q8N3S2Explore the universe of human proteins at neXtProt for TXLNB: NX_Q8N3L3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N3L3
TXLNB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_694967.3
ENSEMBL proteins: ENSP00000351206 ENSP00000356624
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IDA | -- |
TXLNB for ontologies About GeneDecksing
TXLNB Antibody Products:
Assay Products for TXLNB: |
Protein
Domains /
Families
for TXLNB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TXLNB for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N3L3ProtoNet protein and cluster: Q8N3L3 UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3Similarity: Belongs to the taxilin family |
Function
for TXLNB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3Function: Promotes motor nerve regeneration (By similarity). May be involved in intracellular vesicle traffic
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXLNB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXLNB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TXLNB (NM_153235) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXLNB | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXLNB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNB |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- | | GO:0019905 | syntaxin binding |
IEA | -- |
TXLNB for ontologies About GeneDecksing
|
Pathways & Interactions
for TXLNB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TXLNB
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for TXLNB (Q8N3L31, 3 ENSP000003512064) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TXLNB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TXLNB
Search CenterWatch for drugs/clinical trials and news about TXLNB
|
Transcripts
for TXLNB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TXLNB gene: NM_153235.3 Unigene Cluster for TXLNB: Taxilin beta Hs.535820 [show with all ESTs]Unigene Representative Sequence: NM_1532352 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000358430(uc021zfy.1) ENST00000367652
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXLNB (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXLNB
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TXLNB (NM_153235) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXLNB | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXLNB |
Additional cDNA sequence: AB085905.1 AF111704.1 AK056970.1 AK314725.1 AL831988.1 AL832322.1 AL834248.2 BC115383.1 BC115384.2 BX647477.1 BX647633.1 7 DOTS entries: DT.99951056 DT.309367 DT.86857086 DT.121340460 DT.100749620 DT.121340367 DT.203905 24/41 AceView cDNA sequences (see all 41): CB054121 AA233930 AB085905 BX500133 AL589616 AF111704 AA918450 AI589117 CD359961 AI276991 AL589617 BF576885 BX099223 AL589618 AW074101 BX501781 AI039795 BX647477 AL831988 BX101595 AI015340 AL832322 BV205404 AL589615
GeneLoc Exon Structure
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Expression
for TXLNB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TXLNB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATATCTTGG
About this image
See TXLNB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TXLNB
SOURCE GeneReport for Unigene cluster: Hs.535820
UniProtKB/Swiss-Prot: TXLNB_HUMAN, Q8N3L3Tissue specificity: Expressed in skeletal muscle
SABiosciences Custom PCR Arrays for TXLNB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXLNB
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXLNB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXLNB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXLNB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNB |
Orthologs
for TXLNB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TXLNB gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for TXLNB (if available)
TreeFam Gene Tree for TXLNB (if available) |
Paralogs
for TXLNB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TXLNB gene
- TXLNA2 TXLNG2
5 SIMAP similar genes for TXLNB using alignment to 4 protein entries: TXLNB_HUMAN (see all proteins):DKFZp451B226 DKFZp451H216 TXLNA TXLNG CYorf15B
TXLNB for paralogs About GeneDecksing
|
Genomic Variants
for TXLNB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TXLNB (139561198 - 139613276 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for TXLNB
8 CNVs: 59300 94063 7526 64670 94062 81614 36463 37448
1 Indel: 47007 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXLNB |
|
Disorders
/ Diseases
for TXLNB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TXLNB for disorders About GeneDecksing
OMIM gene information: 611438
OMIM disorders: --
1  disease for TXLNB: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: TXLNB (1 document)
Export disorders for TXLNB gene to outside databases
|
Publications
for TXLNB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TXLNB gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with TXLNB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and characterization of taxilin isoforms. (PubMed id 15184072)1, 2, 3 Nogami S.... Shirataki H. (2004)
- Muscle-specific protein MDP77 specifically promotes motor nerve regeneration in rats. (PubMed id 15082161)1, 2 Itoh S.... Taguchi T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
|
External Searches for TXLNB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TXLNB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TXLNB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TXLNB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TXLNB | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TXLNB gene:
Search GeneIP for patents involving TXLNB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TXLNB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TXLNB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXLNB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXLNB | | | OriGene Protein Over-expression Lysate for TXLNB | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TXLNB | | OriGene 3'-UTR Clone for TXLNB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXLNB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXLNB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TXLNB | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TXLNB | | OriGene Custom Protein Services for TXLNB | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXLNB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXLNB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXLNB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXLNB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXLNB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXLNB |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNB |
|  |  |  | | | | Search ThermoFisher Antibodies for TXLNB |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXLNB |
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