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Aliases for TXLNA Gene

Aliases for TXLNA Gene

  • Taxilin Alpha 2 3 5
  • TXLN 3 4
  • Interleukin 14 3
  • IL14 3

External Ids for TXLNA Gene

Previous GeneCards Identifiers for TXLNA Gene

  • GC01P032315
  • GC01P032417
  • GC01P032645
  • GC01P030761

Summaries for TXLNA Gene

GeneCards Summary for TXLNA Gene

TXLNA (Taxilin Alpha) is a Protein Coding gene. Diseases associated with TXLNA include inclusion conjunctivitis. Among its related pathways are Immune System and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include cytokine activity and high molecular weight B cell growth factor receptor binding. An important paralog of this gene is TXLNB.

UniProtKB/Swiss-Prot for TXLNA Gene

  • May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Wiki entry for TXLNA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNA Gene

Genomics for TXLNA Gene

Regulatory Elements for TXLNA Gene

Promoters for TXLNA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TXLNA on UCSC Golden Path with GeneCards custom track

Genomic Location for TXLNA Gene

Chromosome:
1
Start:
32,179,686 bp from pter
End:
32,198,285 bp from pter
Size:
18,600 bases
Orientation:
Plus strand

Genomic View for TXLNA Gene

Genes around TXLNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXLNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXLNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNA Gene

Proteins for TXLNA Gene

  • Protein details for TXLNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40222-TXLNA_HUMAN
    Recommended name:
    Alpha-taxilin
    Protein Accession:
    P40222
    Secondary Accessions:
    • D3DPP6
    • Q5TFJ6
    • Q66K62
    • Q86T54
    • Q86T85
    • Q86T86
    • Q86Y86
    • Q86YW3
    • Q8N2Y3

    Protein attributes for TXLNA Gene

    Size:
    546 amino acids
    Molecular mass:
    61891 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.
    SequenceCaution:
    • Sequence=AAH46565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXLNA Gene

Proteomics data for TXLNA Gene at MOPED

Post-translational modifications for TXLNA Gene

  • Ubiquitination at Lys 403
  • Modification sites at PhosphoSitePlus

Other Protein References for TXLNA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TXLNA (alpha-Taxilin)

No data available for DME Specific Peptides for TXLNA Gene

Domains & Families for TXLNA Gene

Protein Domains for TXLNA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TXLNA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40222

UniProtKB/Swiss-Prot:

TXLNA_HUMAN :
  • Belongs to the taxilin family.
Family:
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNA: view

No data available for Gene Families for TXLNA Gene

Function for TXLNA Gene

Molecular function for TXLNA Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Ontology (GO) - Molecular Function for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
genes like me logo Genes that share ontologies with TXLNA: view
genes like me logo Genes that share phenotypes with TXLNA: view

Animal Model Products

miRNA for TXLNA Gene

miRTarBase miRNAs that target TXLNA

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXLNA Gene

Localization for TXLNA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXLNA Gene COMPARTMENTS Subcellular localization image for TXLNA gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TXLNA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TXLNA Gene

Pathways & Interactions for TXLNA Gene

genes like me logo Genes that share pathways with TXLNA: view

Pathways by source for TXLNA Gene

1 BioSystems pathway for TXLNA Gene

Gene Ontology (GO) - Biological Process for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
genes like me logo Genes that share ontologies with TXLNA: view

No data available for SIGNOR curated interactions for TXLNA Gene

Drugs & Compounds for TXLNA Gene

(1) Drugs for TXLNA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with TXLNA: view

Transcripts for TXLNA Gene

Unigene Clusters for TXLNA Gene

Taxilin alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for TXLNA Gene

GeneLoc Exon Structure for
TXLNA
ECgene alternative splicing isoforms for
TXLNA

Expression for TXLNA Gene

mRNA expression in normal human tissues for TXLNA Gene

Protein differential expression in normal tissues from HIPED for TXLNA Gene

This gene is overexpressed in Breast (25.6), Urine (8.0), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXLNA Gene



SOURCE GeneReport for Unigene cluster for TXLNA Gene Hs.17987

mRNA Expression by UniProt/SwissProt for TXLNA Gene

P40222-TXLNA_HUMAN
Tissue specificity: Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.
genes like me logo Genes that share expression patterns with TXLNA: view

Protein tissue co-expression partners for TXLNA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TXLNA Gene

Orthologs for TXLNA Gene

This gene was present in the common ancestor of animals.

Orthologs for TXLNA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TXLNA 35
  • 89.54 (n)
  • 92.29 (a)
TXLNA 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXLNA 35
  • 90.15 (n)
  • 94.5 (a)
TXLNA 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txlna 35
  • 87.39 (n)
  • 91.14 (a)
Txlna 16
Txlna 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TXLNA 35
  • 99.52 (n)
  • 99.52 (a)
TXLNA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txlna 35
  • 87.34 (n)
  • 89.91 (a)
oppossum
(Monodelphis domestica)
Mammalia TXLNA 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXLNA 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXLNA 35
  • 73.69 (n)
  • 78.54 (a)
TXLNA 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXLNA 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1214 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7529 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
txlna 35
  • 70.88 (n)
  • 73.64 (a)
txlna 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009667 35
  • 55.83 (n)
  • 39.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 35
  • 53.64 (n)
  • 39.74 (a)
CG5886 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22C1.6 35
  • 43.64 (n)
  • 36.73 (a)
T22C1.6 36
  • 28 (a)
OneToMany
Species with no ortholog for TXLNA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNA Gene

ENSEMBL:
Gene Tree for TXLNA (if available)
TreeFam:
Gene Tree for TXLNA (if available)

Paralogs for TXLNA Gene

Paralogs for TXLNA Gene

(5) SIMAP similar genes for TXLNA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXLNA: view

Variants for TXLNA Gene

Sequence variations from dbSNP and Humsavar for TXLNA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs13142 -- 32,198,122(-) AAGNC(A/C)GCTCC utr-variant-3-prime
rs1051110 -- 32,196,750(+) CAGGT(A/C)CCTTC utr-variant-3-prime
rs1054596 -- 32,179,310(-) CTGAG(A/G)CTCAG upstream-variant-2KB
rs1358823 -- 32,198,036(+) CCCCA(G/T)CCTTT utr-variant-3-prime
rs2281385 -- 32,191,963(+) CATTC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXLNA Gene

Variant ID Type Subtype PubMed ID
nsv7745 CNV Insertion 18451855

Variation tolerance for TXLNA Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXLNA Gene

HapMap Linkage Disequilibrium report
TXLNA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNA Gene

Disorders for TXLNA Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXLNA Gene - From: DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • adult inclusion conjunctivitis
- elite association - COSMIC cancer census association via MalaCards
Search TXLNA in MalaCards View complete list of genes associated with diseases

Relevant External Links for TXLNA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXLNA
genes like me logo Genes that share disorders with TXLNA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXLNA Gene

Publications for TXLNA Gene

  1. Interaction of taxilin with syntaxin which does not form the SNARE complex. (PMID: 14623251) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 67
  2. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2004) 2 3 23
  3. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. (PMID: 12558796) Nogami S. … Shirataki H. (Genes Cells 2003) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TXLNA Gene

Sources for TXLNA Gene

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