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TXLNA Gene

protein-coding   GIFtS: 57
GCID: GC01P032645

Taxilin Alpha

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Taxilin Alpha1 2
TXLN2 3
IL142
alpha-taxilin2
Interleukin 142

External Ids:    HGNC: 306851   Entrez Gene: 2000812   Ensembl: ENSG000000846527   OMIM: 6086765   UniProtKB: P402223   

Export aliases for TXLNA gene to outside databases

Previous GC identifers: GC01P032315 GC01P032417 GC01P030761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXLNA Gene:
TXLNA (taxilin alpha) is a protein-coding gene. Diseases associated with TXLNA include inclusion conjunctivitis, and conjunctivitis. GO annotations related to this gene include high molecular weight B cell growth factor receptor binding and cytokine activity. An important paralog of this gene is TXLNB.

UniProtKB/Swiss-Prot: TXLNA_HUMAN, P40222
Function: May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in
neuroendocrine cells

Gene Wiki entry for TXLNA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXLNA gene promoter:
         Spz1   NF-1   Pax-2   Pax-2a   GATA-1   Gfi-1   IRF-2   POU2F1   POU2F1a   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXLNA promoter sequence
   Search Chromatin IP Primers for TXLNA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXLNA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35

TXLNA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXLNA gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P032645:  view genomic region     (about GC identifiers)

Start:
32,645,287 bp from pter      End:
32,663,886 bp from pter
Size:
18,600 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TXLNA_HUMAN, P40222 (See protein sequence)
Recommended Name: Alpha-taxilin  
Size: 546 amino acids; 61891 Da
Subunit: Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not
when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that
do not form the SNARE complex
Caution: Was originally (PubMed:8327514) thought to be a high molecular weight interleukin (IL-14 or IL14)
Sequence caution: Sequence=AAH46565.1; Type=Erroneous initiation;
Secondary accessions: D3DPP6 Q5TFJ6 Q66K62 Q86T54 Q86T85 Q86T86 Q86Y86 Q86YW3 Q8N2Y3

Explore the universe of human proteins at neXtProt for TXLNA: NX_P40222

Explore proteomics data for TXLNA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys403
  • Modification sites at PhosphoSitePlus

  • See TXLNA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_787048.1  
    ENSEMBL proteins: 
     ENSP00000362712   ENSP00000362711  

    TXLNA Human Recombinant Protein Products:

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    Novus Biologicals TXLNA Lysate
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    Browse Proteins at Cloud-Clone Corp.

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    TXLNA Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026183 Taxilin_fam

    Graphical View of Domain Structure for InterPro Entry P40222

    ProtoNet protein and cluster: P40222

    UniProtKB/Swiss-Prot: TXLNA_HUMAN, P40222
    Similarity: Belongs to the taxilin family


    TXLNA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXLNA_HUMAN, P40222
    Function: May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in
    neuroendocrine cells

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005125cytokine activity NAS8327514
    GO:0005515protein binding IPI--
    GO:0019905syntaxin binding IEA--
    GO:0030372high molecular weight B cell growth factor receptor binding NAS8327514
         
    TXLNA for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TXLNA:
     Cells with protrusions 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXLNA
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXLNA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXLNA

    miRNA
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    miRTarBase miRNAs that target TXLNA:
    hsa-mir-92a-3p (MIRT048916), hsa-let-7b-5p (MIRT052326), hsa-mir-17-5p (MIRT051050), hsa-mir-877-3p (MIRT036999), hsa-mir-1227-3p (MIRT036404), hsa-mir-196b-5p (MIRT042685), hsa-mir-423-3p (MIRT042571), hsa-mir-15b-5p (MIRT046467), hsa-mir-32-5p (MIRT028309), hsa-mir-320b (MIRT036214), hsa-mir-26b-5p (MIRT029654), hsa-mir-193b-3p (MIRT041508), hsa-mir-124-3p (MIRT022710), hsa-mir-484 (MIRT041686)

    Block miRNA regulation of human, mouse, rat TXLNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXLNA (see all 97):
    hsa-miR-579 hsa-miR-520e hsa-miR-3194-5p hsa-miR-1914* hsa-miR-106a hsa-miR-3161 hsa-miR-93 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TXLNA

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TXLNA (see all 7)
    OriGene ORF clones in mouse, rat for TXLNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXLNA (NM_175852)
    Sino Biological Human cDNA Clone for TXLNA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXLNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXLNA

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus3
    cytosol2
    cytoskeleton1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS8327514
    GO:0005737cytoplasm IDA--

    TXLNA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TXLNA About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for TXLNA
        TNF-alpha/NF-kB Signaling Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including TXLNA: 
              Common Cytokines in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TXLNA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for TXLNA (P402221, 2, 3 ENSP000003627114) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-47972 MINT-48227 I2D: score=4 
    NACAQ137651, 3, ENSP000004038174EBI-359793,EBI-712216 I2D: score=1 STRING: ENSP00000403817
    TBK1Q9UHD21, 3, ENSP000003299674EBI-359793,EBI-356402 I2D: score=1 STRING: ENSP00000329967
    TXLNBQ8N3L31, 3, ENSP000003512064EBI-359793,EBI-6116822 I2D: score=1 STRING: ENSP00000351206
    RGS20O760813, ENSP000002973134I2D: score=2 STRING: ENSP00000297313
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006887exocytosis IEA--
    GO:0008283cell proliferation NAS8327514
    GO:0042113B cell activation IEA--

    TXLNA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXLNA

    1 HMDB Compound for TXLNA    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TXLNA gene: 
    NM_175852.3  

    Unigene Cluster for TXLNA:

    Taxilin alpha
    Hs.17987  [show with all ESTs]
    Unigene Representative Sequence: AL832637
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373610(uc001bui.3) ENST00000373609(uc001buj.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TXLNA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXLNA (see all 97):
    hsa-miR-579 hsa-miR-520e hsa-miR-3194-5p hsa-miR-1914* hsa-miR-106a hsa-miR-3161 hsa-miR-93 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TXLNA
    Predesigned siRNA for gene silencing in human, mouse, rat TXLNA
    Clone
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    OriGene clones in human, mouse for TXLNA (see all 7)
    OriGene ORF clones in mouse, rat for TXLNA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXLNA (NM_175852)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXLNA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXLNA
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TXLNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXLNA
      QuantiTect SYBR Green Assays in human, mouse, rat TXLNA
      QuantiFast Probe-based Assays in human, mouse, rat TXLNA

    Additional mRNA sequence: 

    AF070546.1 AF516206.1 AK096161.1 AK096939.1 AL713662.1 AL832338.1 AL832636.2 AL832637.2 
    BC029686.1 BC046565.1 BC065263.1 BC080578.1 BC103823.1 BC103824.1 BC103825.1 L15344.1 

    13 DOTS entries:

    DT.217180  DT.100020508  DT.99930768  DT.121395557  DT.86840926  DT.91748392  DT.121395498  DT.121395554 
    DT.217179  DT.75115182  DT.91748389  DT.95100879  DT.303259 

    Selected AceView cDNA sequences (see all 332):

    CN480364 CB134982 BG169290 AI126691 BC029686 AA629313 BU538767 AI816239 
    BM550608 AI815547 AA280887 BQ054155 BC002462 CA417053 BE513525 AW294086 
    AI419038 BE857092 BU726101 BE858528 BC065263 BC080578 NM_175852 AI200529 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TXLNA    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
    SP1:                    -                                                                 -                       -               
    SP2:                                                                                      -                       -               
    SP3:                    -                                   -     -     -     -     -                                             
    SP4:                    -     -                                                                                                   
    SP5:                                                              -                                                               


    ECgene alternative splicing isoforms for TXLNA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXLNA expression in normal human tissues (normalized intensities)      TXLNA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGAGCTC
    TXLNA Expression
    About this image


    TXLNA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TXLNA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXLNA Protein Expression

    Genevestigator expression for TXLNA

    SOURCE GeneReport for Unigene cluster: Hs.17987

    UniProtKB/Swiss-Prot: TXLNA_HUMAN, P40222
    Tissue specificity: Ubiquitous, with much higher expression in heart, kidney, liver and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including TXLNA: 
              Common Cytokines in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TXLNA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXLNA
    QuantiTect SYBR Green Assays in human, mouse, rat TXLNA
    QuantiFast Probe-based Assays in human, mouse, rat TXLNA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXLNA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TXLNA gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txlna1 , 5 taxilin alpha1, 5 87.39(n)1
    91.14(a)1
      4 (63.26 cM)5
    1096581  NM_001005506.31  NP_001005506.21 
     1296260835 
    chicken
    (Gallus gallus)
    Aves TXLNA1 taxilin alpha 73.69(n)
    78.54(a)
      419648  XM_004947816.1  XP_004947873.1 
    lizard
    (Anolis carolinensis)
    Reptilia TXLNA6
    taxilin alpha
    88(a)
    1 ↔ 1
    GL343706.1(158137-166687)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.75292 Xenopus laevis transcribed sequence with moderate similarity to protein refNP_060830.1 (H.sapiens) hypothetical protein FLJ11209 [Homo sapiens] less 80.06(n)    BJ618489.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK238520.12   -- 76.94(n)   324984  CK238520.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58861 CG5886 53.64(n)
    39.74(a)
      43125  NM_143178.1  NP_651435.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T22C1.61 T22C1.6 43.64(n)
    36.73(a)
      172568  NM_059791.4  NP_492192.1 


    ENSEMBL Gene Tree for TXLNA (if available)
    TreeFam Gene Tree for TXLNA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXLNA gene
    TXLNB2  TXLNG2  
    5 SIMAP similar genes for TXLNA using alignment to 2 protein entries:     TXLNA_HUMAN (see all proteins):
    DKFZp667F1912    TXLNB    TXLNG    DKFZp451B226    DKFZp451H216

    TXLNA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXLNA (see all 446)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1862203121,2
    --32643395(+) ATACAA/GTCTGG 1 -- us2k10--------
    rs1445016761,2
    --32643462(+) CTGCAA/GTCACC 1 -- us2k10--------
    rs1484174721,2
    --32643542(+) TTGTTA/GACCTA 1 -- us2k10--------
    rs1161680301,2
    F--32643842(+) TATCTC/TTTATC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs49494951,2
    C,H--32644104(+) AAATTC/AACTGA 1 -- us2k1 tfbs313Minor allele frequency- A:0.00NS NA WA CSA 367
    rs1471311711,2
    --32644133(+) TTTCAA/GCACCT 1 -- us2k10--------
    rs1913645601,2
    --32644166(+) CTGCAA/GACCTA 1 -- us2k10--------
    rs772360401,2
    F--32644399(+) GACTTT/CGTAGA 1 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1402811341,2
    --32644653(+) ATGACC/TTTGGA 1 -- us2k10--------
    rs1809763751,2
    --32644753(+) GCTATC/TAGATA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TXLNA (32645287 - 32663886 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TXLNA:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv7745CNV Insertion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TXLNA
    DNA2.0 Custom Variant and Variant Library Synthesis for TXLNA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608676    OMIM disorders: --

    9 diseases for TXLNA:    About MalaCards
    inclusion conjunctivitis    conjunctivitis    tonsillitis    hepatocellular carcinoma
    malaria    thyroiditis    cerebritis    endotheliitis
    prostatitis


    TXLNA for disorders           About GeneDecksing


    Export disorders for TXLNA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXLNA gene, integrated from 10 sources (see all 47):
    (articles sorted by number of sources associating them with TXLNA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of taxilin with syntaxin which does not form the SNARE complex. (PubMed id 14623251)1, 2, 3 Nogami S.... Shirataki H. (Biochem. Biophys. Res. Commun. 2003)
    2. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. (PubMed id 12558796)1, 2, 9 Nogami S.... Shirataki H. (Genes Cells 2003)
    3. Identification and characterization of taxilin isoforms. (PubMed id 15184072)1, 3, 9 Nogami S.... Shirataki H. (Biochem. Biophys. Res. Commun. 2004)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of a cDNA for a human high molecular-weight B-cell growth factor. (PubMed id 8755619)1, 2 Ambrus J.L....Ford R. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    7. Identification of a cDNA for a human high-molecular-weight B-cell growth factor. (PubMed id 8327514)1, 2 Ambrus J.L. Jr.... Ford R.J. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Interaction of I+-taxilin localized on intracellular components with the microtubule cytoskeleton. (PubMed id 22785156)1 Horii Y....Shirataki H. (Cell Struct. Funct. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 200081 HGNC: 30685 AceView: MGC1203andDKFZp451J0118 Ensembl:ENSG00000084652 euGenes: HUgn200081
    ECgene: TXLNA H-InvDB: TXLNA

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TXLNA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TXLNA gene:
    Search GeneIP for patents involving TXLNA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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