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Aliases for TXLNA Gene

Aliases for TXLNA Gene

  • Taxilin Alpha 2 3
  • TXLN 3 4
  • Interleukin 14 3
  • Alpha-Taxilin 3
  • IL14 3

External Ids for TXLNA Gene

Previous GeneCards Identifiers for TXLNA Gene

  • GC01P032315
  • GC01P032417
  • GC01P032645
  • GC01P030761

Summaries for TXLNA Gene

GeneCards Summary for TXLNA Gene

TXLNA (Taxilin Alpha) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include cytokine activity and high molecular weight B cell growth factor receptor binding. An important paralog of this gene is TXLNB.

UniProtKB/Swiss-Prot for TXLNA Gene

  • May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells

Gene Wiki entry for TXLNA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNA Gene

Genomics for TXLNA Gene

Regulatory Elements for TXLNA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TXLNA Gene

Start:
32,179,686 bp from pter
End:
32,198,285 bp from pter
Size:
18,600 bases
Orientation:
Plus strand

Genomic View for TXLNA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXLNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNA Gene

Proteins for TXLNA Gene

  • Protein details for TXLNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40222-TXLNA_HUMAN
    Recommended name:
    Alpha-taxilin
    Protein Accession:
    P40222
    Secondary Accessions:
    • D3DPP6
    • Q5TFJ6
    • Q66K62
    • Q86T54
    • Q86T85
    • Q86T86
    • Q86Y86
    • Q86YW3
    • Q8N2Y3

    Protein attributes for TXLNA Gene

    Size:
    546 amino acids
    Molecular mass:
    61891 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.
    SequenceCaution:
    • Sequence=AAH46565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXLNA Gene

Proteomics data for TXLNA Gene at MOPED

Post-translational modifications for TXLNA Gene

  • Ubiquitination at Lys403
  • Modification sites at PhosphoSitePlus

Other Protein References for TXLNA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TXLNA (alpha-Taxilin)

No data available for DME Specific Peptides for TXLNA Gene

Domains for TXLNA Gene

Protein Domains for TXLNA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TXLNA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40222

UniProtKB/Swiss-Prot:

TXLNA_HUMAN :
  • P40222
Family:
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNA: view

No data available for Gene Families for TXLNA Gene

Function for TXLNA Gene

Molecular function for TXLNA Gene

UniProtKB/Swiss-Prot Function: May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells

Gene Ontology (GO) - Molecular Function for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 8327514
GO:0005515 protein binding IPI 21903422
GO:0019905 syntaxin binding IEA --
GO:0030372 high molecular weight B cell growth factor receptor binding NAS 8327514
genes like me logo Genes that share ontologies with TXLNA: view

Phenotypes for TXLNA Gene

GenomeRNAi human phenotypes for TXLNA:
genes like me logo Genes that share phenotypes with TXLNA: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXLNA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TXLNA Gene

Localization for TXLNA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXLNA Gene COMPARTMENTS Subcellular localization image for TXLNA gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 8327514
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TXLNA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TXLNA Gene

Pathways for TXLNA Gene

genes like me logo Genes that share pathways with TXLNA: view

Pathways by source for TXLNA Gene

1 BioSystems pathway for TXLNA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0008283 cell proliferation NAS 8327514
GO:0042113 B cell activation IEA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with TXLNA: view

Compounds for TXLNA Gene

(1) HMDB Compounds for TXLNA Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with TXLNA: view

Transcripts for TXLNA Gene

Unigene Clusters for TXLNA Gene

Taxilin alpha:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXLNA

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TXLNA
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for TXLNA Gene

GeneLoc Exon Structure for
TXLNA
ECgene alternative splicing isoforms for
TXLNA

Expression for TXLNA Gene

mRNA expression in normal human tissues for TXLNA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TXLNA Gene

SOURCE GeneReport for Unigene cluster for TXLNA Gene Hs.17987

mRNA Expression by UniProt/SwissProt for TXLNA Gene

P40222-TXLNA_HUMAN
Tissue specificity: Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.
genes like me logo Genes that share expressions with TXLNA: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TXLNA Gene

Orthologs for TXLNA Gene

This gene was present in the common ancestor of animals.

Orthologs for TXLNA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXLNA 35
  • 99.52 (n)
  • 99.52 (a)
TXLNA 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TXLNA 35
  • 89.54 (n)
  • 92.29 (a)
TXLNA 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXLNA 35
  • 90.15 (n)
  • 94.5 (a)
TXLNA 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txlna 35
  • 87.39 (n)
  • 91.14 (a)
Txlna 16
Txlna 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TXLNA 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXLNA 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txlna 35
  • 87.34 (n)
  • 89.91 (a)
chicken
(Gallus gallus)
Aves TXLNA 35
  • 73.69 (n)
  • 78.54 (a)
TXLNA 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TXLNA 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7529 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1214 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
txlna 35
  • 70.88 (n)
  • 73.64 (a)
txlna 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009667 35
  • 55.83 (n)
  • 39.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 35
  • 53.64 (n)
  • 39.74 (a)
CG5886 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T22C1.6 35
  • 43.64 (n)
  • 36.73 (a)
T22C1.6 36
  • 28 (a)
OneToMany
Species with no ortholog for TXLNA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNA Gene

ENSEMBL:
Gene Tree for TXLNA (if available)
TreeFam:
Gene Tree for TXLNA (if available)

Paralogs for TXLNA Gene

Paralogs for TXLNA Gene

Selected SIMAP similar genes for TXLNA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXLNA: view

Variants for TXLNA Gene

Sequence variations from dbSNP and Humsavar for TXLNA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs13142 -- 32,198,122(-) AAGNC(A/C)GCTCC utr-variant-3-prime
rs1051110 -- 32,196,750(+) CAGGT(A/C)CCTTC utr-variant-3-prime
rs1054596 -- 32,179,310(-) CTGAG(A/G)CTCAG upstream-variant-2KB
rs1358823 -- 32,198,036(+) CCCCA(G/T)CCTTT utr-variant-3-prime
rs2273164 -- 32,180,585(+) ACTTA(C/G)AGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXLNA Gene

Variant ID Type Subtype PubMed ID
nsv7745 CNV Insertion 18451855

Relevant External Links for TXLNA Gene

HapMap Linkage Disequilibrium report
TXLNA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNA Gene

Disorders for TXLNA Gene

No disorders were found for TXLNA Gene.

No data available for UniProtKB/Swiss-Prot for TXLNA Gene

Publications for TXLNA Gene

  1. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. (PMID: 12558796) Nogami S. … Shirataki H. (Genes Cells 2003) 3 4 23
  2. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2004) 2 3 23
  3. Interaction of taxilin with syntaxin which does not form the SNARE complex. (PMID: 14623251) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2003) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of a cDNA for a human high-molecular-weight B-cell growth factor. (PMID: 8327514) Ambrus J.L. Jr. … Ford R.J. (Proc. Natl. Acad. Sci. U.S.A. 1993) 3 4

Products for TXLNA Gene

Sources for TXLNA Gene

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