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Aliases for TXLNA Gene

Aliases for TXLNA Gene

  • Taxilin Alpha 2 3 5
  • TXLN 3 4
  • Interleukin 14 3
  • Alpha-Taxilin 3
  • IL14 3

External Ids for TXLNA Gene

Previous GeneCards Identifiers for TXLNA Gene

  • GC01P032315
  • GC01P032417
  • GC01P032645
  • GC01P030761

Summaries for TXLNA Gene

GeneCards Summary for TXLNA Gene

TXLNA (Taxilin Alpha) is a Protein Coding gene. Diseases associated with TXLNA include Inclusion Conjunctivitis and Amyotrophic Lateral Sclerosis 10, With Or Without Ftd. Among its related pathways are Immune System and Cytokine Signaling in Immune system. GO annotations related to this gene include cytokine activity and high molecular weight B cell growth factor receptor binding. An important paralog of this gene is TXLNB.

UniProtKB/Swiss-Prot for TXLNA Gene

  • May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Wiki entry for TXLNA Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXLNA Gene

Genomics for TXLNA Gene

Regulatory Elements for TXLNA Gene

Enhancers for TXLNA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F032289 0.6 ENCODE 5.7 +111.6 111634 3.8 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 SNRNP40 ENSG00000224066 LOC105378626 MTMR9LP EIF3I FAM167B TSSK3 IQCC KPNA6 LRRC37A12P
GH01F032271 1.1 Ensembl ENCODE 4.7 +93.9 93864 5.1 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF263 SP3 SNRNP40 TSSK3 MTMR9LP ENSG00000224066 ZBTB8B KPNA6 LRRC37A12P TXLNA ENSG00000277617 ENSG00000252450
GH01F032262 1 FANTOM5 Ensembl ENCODE 4.5 +85.7 85702 4.8 ZFP64 ZNF493 ZNF121 FOS REST ZNF518A ZNF623 ZNF264 MEF2D ZNF292 SNRNP40 TSSK3 EIF3I ENSG00000270115 MTMR9LP ENSG00000224066 DCDC2B LOC105378626 IQCC KPNA6
GH01F032132 0.8 Ensembl ENCODE 4.3 -46.3 -46276 2.3 HDGF PKNOX1 ARNT CREB3L1 SIN3A CBX5 ZNF548 FOS KLF13 REST SNRNP40 KPNA6 ENSG00000224066 ENSG00000229447 IQCC TSSK3 EIF3I CCDC28B DCDC2B TMEM234
GH01F031888 1 FANTOM5 Ensembl ENCODE 4.1 -290.2 -290186 2.2 HDGF TBP HDAC1 PKNOX1 ATF1 TBL1XR1 NFRKB RAD21 ZBTB40 YY1 MTMR9LP SPOCD1 TXLNA LCK PTP4A2 PEF1 GC01M031855 GC01M031906
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TXLNA on UCSC Golden Path with GeneCards custom track

Promoters for TXLNA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001038805 514 2001 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for TXLNA Gene

Chromosome:
1
Start:
32,179,686 bp from pter
End:
32,198,285 bp from pter
Size:
18,600 bases
Orientation:
Plus strand

Genomic View for TXLNA Gene

Genes around TXLNA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TXLNA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TXLNA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXLNA Gene

Proteins for TXLNA Gene

  • Protein details for TXLNA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40222-TXLNA_HUMAN
    Recommended name:
    Alpha-taxilin
    Protein Accession:
    P40222
    Secondary Accessions:
    • D3DPP6
    • Q5TFJ6
    • Q66K62
    • Q86T54
    • Q86T85
    • Q86T86
    • Q86Y86
    • Q86YW3
    • Q8N2Y3

    Protein attributes for TXLNA Gene

    Size:
    546 amino acids
    Molecular mass:
    61891 Da
    Quaternary structure:
    • Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.
    SequenceCaution:
    • Sequence=AAH46565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TXLNA Gene

Post-translational modifications for TXLNA Gene

  • Ubiquitination at Lys 403
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for TXLNA (alpha-Taxilin)
  • Cloud-Clone Corp. Antibodies for TXLNA

No data available for DME Specific Peptides for TXLNA Gene

Domains & Families for TXLNA Gene

Protein Domains for TXLNA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TXLNA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P40222

UniProtKB/Swiss-Prot:

TXLNA_HUMAN :
  • Belongs to the taxilin family.
Family:
  • Belongs to the taxilin family.
genes like me logo Genes that share domains with TXLNA: view

No data available for Gene Families for TXLNA Gene

Function for TXLNA Gene

Molecular function for TXLNA Gene

UniProtKB/Swiss-Prot Function:
May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.

Gene Ontology (GO) - Molecular Function for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity NAS 8327514
GO:0005515 protein binding IPI 21903422
GO:0019905 syntaxin binding IEA --
GO:0030372 high molecular weight B cell growth factor receptor binding NAS 8327514
genes like me logo Genes that share ontologies with TXLNA: view
genes like me logo Genes that share phenotypes with TXLNA: view

Animal Model Products

miRNA for TXLNA Gene

miRTarBase miRNAs that target TXLNA

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TXLNA Gene

Localization for TXLNA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXLNA Gene COMPARTMENTS Subcellular localization image for TXLNA gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005737 cytoplasm IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with TXLNA: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TXLNA Gene

Pathways & Interactions for TXLNA Gene

genes like me logo Genes that share pathways with TXLNA: view

Pathways by source for TXLNA Gene

Gene Ontology (GO) - Biological Process for TXLNA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006887 exocytosis IEA --
GO:0008283 cell proliferation NAS 8327514
GO:0042113 B cell activation IEA --
genes like me logo Genes that share ontologies with TXLNA: view

No data available for SIGNOR curated interactions for TXLNA Gene

Drugs & Compounds for TXLNA Gene

(1) Drugs for TXLNA Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with TXLNA: view

Transcripts for TXLNA Gene

Unigene Clusters for TXLNA Gene

Taxilin alpha:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXLNA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - -
SP2: - -
SP3: - - - - - -
SP4: - -
SP5: -

Relevant External Links for TXLNA Gene

GeneLoc Exon Structure for
TXLNA
ECgene alternative splicing isoforms for
TXLNA

Expression for TXLNA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TXLNA Gene

Protein differential expression in normal tissues from HIPED for TXLNA Gene

This gene is overexpressed in Breast (25.6), Urine (8.0), and Lymph node (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TXLNA Gene



Protein tissue co-expression partners for TXLNA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TXLNA Gene:

TXLNA

SOURCE GeneReport for Unigene cluster for TXLNA Gene:

Hs.17987

mRNA Expression by UniProt/SwissProt for TXLNA Gene:

P40222-TXLNA_HUMAN
Tissue specificity: Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.
genes like me logo Genes that share expression patterns with TXLNA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TXLNA Gene

Orthologs for TXLNA Gene

This gene was present in the common ancestor of animals.

Orthologs for TXLNA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TXLNA 34 35
  • 99.52 (n)
dog
(Canis familiaris)
Mammalia TXLNA 34 35
  • 90.15 (n)
cow
(Bos Taurus)
Mammalia TXLNA 34 35
  • 89.54 (n)
mouse
(Mus musculus)
Mammalia Txlna 34 16 35
  • 87.39 (n)
rat
(Rattus norvegicus)
Mammalia Txlna 34
  • 87.34 (n)
oppossum
(Monodelphis domestica)
Mammalia TXLNA 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TXLNA 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves TXLNA 34 35
  • 73.69 (n)
lizard
(Anolis carolinensis)
Reptilia TXLNA 35
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1214 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7529 34
zebrafish
(Danio rerio)
Actinopterygii txlna 34 35
  • 70.88 (n)
-- 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009667 34
  • 55.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5886 34 35
  • 53.64 (n)
worm
(Caenorhabditis elegans)
Secernentea T22C1.6 34 35
  • 43.64 (n)
Species where no ortholog for TXLNA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TXLNA Gene

ENSEMBL:
Gene Tree for TXLNA (if available)
TreeFam:
Gene Tree for TXLNA (if available)

Paralogs for TXLNA Gene

Paralogs for TXLNA Gene

(5) SIMAP similar genes for TXLNA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TXLNA: view

Variants for TXLNA Gene

Sequence variations from dbSNP and Humsavar for TXLNA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1051110 -- 32,196,750(+) CAGGT(A/C)CCTTC utr-variant-3-prime
rs1054596 -- 32,179,310(-) CTGAG(A/G)CTCAG upstream-variant-2KB
rs10551696 -- 32,190,357(+) TTTCT(-/TCC)TCCTC intron-variant
rs10914537 -- 32,197,397(+) GGAAT(A/G)TGGGC utr-variant-3-prime
rs111273711 -- 32,184,649(+) CCCTG(C/T)GTTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TXLNA Gene

Variant ID Type Subtype PubMed ID
nsv7745 CNV insertion 18451855

Variation tolerance for TXLNA Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXLNA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TXLNA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXLNA Gene

Disorders for TXLNA Gene

MalaCards: The human disease database

(2) MalaCards diseases for TXLNA Gene - From: DISEASES

Disorder Aliases PubMed IDs
inclusion conjunctivitis
  • adult inclusion conjunctivitis
amyotrophic lateral sclerosis 10, with or without ftd
  • frontotemporal lobar degeneration, tardbp-related
- elite association - COSMIC cancer census association via MalaCards
Search TXLNA in MalaCards View complete list of genes associated with diseases

Relevant External Links for TXLNA

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXLNA
genes like me logo Genes that share disorders with TXLNA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXLNA Gene

Publications for TXLNA Gene

  1. Identification and characterization of taxilin isoforms. (PMID: 15184072) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2004) 2 3 22 64
  2. Interaction of taxilin with syntaxin which does not form the SNARE complex. (PMID: 14623251) Nogami S. … Shirataki H. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 64
  3. Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. (PMID: 12558796) Nogami S. … Shirataki H. (Genes Cells 2003) 3 4 22 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TXLNA Gene

Sources for TXLNA Gene

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