TXK Gene
protein-coding GIFtS: 66
GCID: GC04M047984
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|
TXK tyrosine kinase(Previous name: PTK4 protein tyrosine kinase 4 )
(Previous symbol: PTK4)
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Aliases
for TXK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TXK Tyrosine Kinase1 2 | | Protein-Tyrosine Kinase 42 3 | | PTK41 2 3 | | Resting Lymphocyte Kinase2 3 | | RLK1 2 3 | | EC 2.7.10.23 8 | | BTKL1 2 5 | | Tyrosine Kinase2 | | PSCTK51 2 | | Tyrosine-Protein Kinase TXK2 | | TKL1 2 | | EC 2.7.108 | | PTK4 Protein Tyrosine Kinase 41 2 | | |
Export aliases for TXK gene to outside databasesPrevious GC identifers: GC04M048145 GC04M048378 GC04M047918 GC04M047909 GC04M047763 GC04M047388 |
Summaries
for TXK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TXK_HUMAN, P42681Function: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immuneresponse. Regulates the development, function and differentiation of conventional T-cells and nonconventionalNKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to therecruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK fullactivation. Contributes also to signaling from many receptors and participates in multiple downstream pathways,including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization inlipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulumreleases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleusto perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1)cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thusinvolved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sitesin LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads tothe association of PI-3 kinase with the CTLA4 receptor
Gene Wiki entry for TXK
|
Genomic Views
for TXK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006238.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TXK gene promoter:
STAT1 AP-1 ATF-2 STAT1alpha IRF-2 POU2F1 POU2F1a c-Myb c-Jun RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for TXK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p12 Ensembl cytogenetic band: 4p12 HGNC cytogenetic band: 4p12TXK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M047984: view genomic region
(about GC identifiers)
Start:
|
48,068,410 bp from pter |
End:
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48,136,273 bp from pter |
Size:
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67,864 bases |
Orientation:
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minus strand |
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Proteins
for TXK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TXK_HUMAN, P42681 (See
protein sequence)Recommended Name: Tyrosine-protein kinase TXK Size: 527 amino acids; 61258 Da
Subunit: Interacts with PARP1 and EEF1A1. Interacts with SH2D2A (By similarity)
Subcellular location: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity ofcell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhancesIFN-gamma gene transcription in T-cells
Caution: Unlike the other TEC subfamily members, TXK is activated independently of the activity of phosphatidylinositol3-kinase, consistent with its lack of a PH domain. Membrane association is performed through palmitoylation at theN-terminus
1 PDB 3D structure from  and Proteopedia  for TXK:2DM0 (3D)
Secondary accessions: Q14220Explore the universe of human proteins at neXtProt for TXK: NX_P42681
Post-translational modifications:
Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to theup-regulation of IFN-gamma gene transcription1
The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P42681
4/8 DME Specific Peptides for TXK (P42681) (see all 8)
TXK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003319.2
ENSEMBL proteins: ENSP00000264316 ENSP00000422139 ENSP00000423481 ENSP00000424070 ENSP00000422798
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TXK for ontologies About GeneDecksing
TXK Antibody Products:
Assay Products for TXK: |
Protein
Domains /
Families
for TXK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TXK for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry P42681ProtoNet protein and cluster: P42681 3 Blocks protein families: IPB000980 SH2 domain signature IPB001452 SH3 domain signature IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: TXK_HUMAN, P42681Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamilySimilarity: Contains 1 protein kinase domainSimilarity: Contains 1 SH2 domainSimilarity: Contains 1 SH3 domain |
Function
for TXK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TXK_HUMAN, P42681Function: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immuneresponse. Regulates the development, function and differentiation of conventional T-cells and nonconventionalNKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to therecruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK fullactivation. Contributes also to signaling from many receptors and participates in multiple downstream pathways,including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization inlipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulumreleases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleusto perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1)cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thusinvolved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sitesin LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads tothe association of PI-3 kinase with the CTLA4 receptorCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation: Activated by phosphorylation by FYN Genatlas biochemistry entry for TXK:protein tyrosine kinase 4,non receptor type,SRC family,Tec subfamily
Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TXK (NM_003328) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXK |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001012 | RNA polymerase II regulatory region DNA binding |
IDA | 11859127 | | GO:0004672 | protein kinase activity |
-- | -- | | GO:0004713 | protein tyrosine kinase activity |
-- | -- | | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
TXK for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TXK:
Animal Models:
Mouse knock-out Txktm1Pls for TXK
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Txk):
TXK for phenotypes About GeneDecksing
|
Pathways & Interactions
for TXK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | ICos-ICosL Pathway in T-Helper Cell | | | 2 | Focal Adhesion | | | 3 | Leukocyte transendothelial migration | | | 4 | Akt Signaling | | | 5 | Integrin Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TXK
1  BioSystems Pathway for TXK
1 
Kegg Pathway (Kegg details for TXK):
TXK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TXK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/23 Interacting proteins for TXK (P426812, 3 ENSP000002643164) via UniProtKB, MINT, STRING, and/or I2D (see all 23)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
TXK for ontologies About GeneDecksing
|
Drugs & Compounds
for TXK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TXK for compounds About GeneDecksing
 Browse Tocris compounds for TXK
2 HMDB Compounds for TXK About this table
4 Novoseek chemical compound relationships for TXK gene About this table
Search CenterWatch for drugs/clinical trials and news about TXK
|
Transcripts
for TXK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TXK gene: NM_003328.2 Unigene Cluster for TXK: TXK tyrosine kinase Hs.479669 [show with all ESTs]Unigene Representative Sequence: NM_0033286 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000264316(uc010igj.3 uc011bzj.2 uc003gxx.4) ENST00000514937
ENST00000507351 ENST00000509681 ENST00000510457(uc003gxy.1) ENST00000506073
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXK (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXK (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TXK (NM_003328) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TXK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXK |
Additional cDNA sequence: AK300141.1 AK307055.1 BC017829.1 L27071.1 9 DOTS entries: DT.100748682 DT.411527 DT.91662293 DT.91689321 DT.100707092 DT.121272929 DT.121272931 DT.95357800 DT.95362158 24/36 AceView cDNA sequences (see all 36): AU135626 AU136430 AU137964 BM562427 AA765195 NM_003328 AU156197 CB148756 AU135099 AU140073 AU118976 BX471176 BX119536 BX380478 BI868877 AU137359 BQ004606 BX369985 BQ023054 L27071 BX370006 BG753882 BV202966 BX496104
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TXK About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c |
|---|
|
| SP1: | | | - | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TXK
|
Expression
for TXK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TXK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTCTCTGGG
About this image
See TXK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TXK
SOURCE GeneReport for Unigene cluster: Hs.479669
UniProtKB/Swiss-Prot: TXK_HUMAN, P42681Tissue specificity: Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells withIFN-gamma-producing potential
SABiosciences Custom PCR Arrays for TXK
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TXK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXK |
Orthologs
for TXK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TXK gene from 5/22 species (see all 22) About this table
ENSEMBL Gene Tree for TXK (if available)
TreeFam Gene Tree for TXK (if available) |
Paralogs
for TXK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TXK gene
- FRK2 LCK2 BLK2 ITK2 LYN2 YES12 HCK2 ABL12
- BMX2 ABL22 SRMS2 TEC2 FGR2 PTK62 SRC2 FYN2
- BTK2
18/89 SIMAP similar genes for TXK using alignment to 7 protein entries: TXK_HUMAN (see all proteins)
(see all similar genes):BTK kinase deficient isoform 4 TEC tec ITK BTK kinase deficient isoform 2 EPHA4
BTK kinase deficient isoform 6 BTK EPHA2 NLK DKFZp686M05208 EGFR
ERBB2 ABL1 CDK10 NTRK3 DDR1 MAPK7
TXK for paralogs About GeneDecksing
|
Genomic Variants
for TXK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TXK
3 Indels: 12447 12448 27661 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXK |
|
Disorders
/ Diseases
for TXK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TXK for disorders About GeneDecksing
OMIM gene information: 600058
OMIM disorders: --
8  diseases for TXK: About MalaCardsbehcet's disease lipomatosis atopic dermatitis chronic myeloid leukemia
agammaglobulinemia dermatitis myeloid leukemia leukemia
2 diseases from the University of Copenhagen DISEASES database for TXK:Chronic myeloid leukemia Lung cancer 3 Novoseek disease relationships for TXK gene About this table
Human Genome Epidemiology (HuGE) Navigator: TXK (6 documents)
Tumor Gene Database (TGDB): TXK
Export disorders for TXK gene to outside databases
|
Publications
for TXK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TXK gene, integrated from 9 sources (see all 63):
(articles sorted by number of sources associating them with TXK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. (PubMed id 7951233)1, 2, 3 Haire R.N.... Litman G.W. (1994)
- Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. (PubMed id 10523612)1, 2, 9 Kashiwakura J....Sakane T. (1999)
- Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. (PubMed id 11859127)1, 2, 9 Takeba Y....Suzuki N. (2002)
- Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene. (PubMed id 8632917)1, 2, 9 Ohta Y....Litman G.W. (1996)
- Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. (PubMed id 9813138)1, 2, 9 Schneider H....Rudd C.E. (1998)
- Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. (PubMed id 12081135)1, 2 Kashiwakura J....Toyoshima S. (2002)
- A YAC contig spanning a cluster of human type III rec eptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12 . (PubMed id 7528718)1, 3 Spritz R.A....Moir D.T. (1994)
- Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. (PubMed id 17177976)2, 9 Maruyama T....Suzuki N. (2007)
- Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk. (PubMed id 11353545)1, 9 Chamorro M....Schwartzberg P.L. (2001)
- Skewed Th1 responses caused by excessive expression of Txk, a member of the Tec family of tyrosine kinases, in patients with Behcet's disease. (PubMed id 16809408)1, 9 Suzuki N....Suzuki T. (2006)
|
External Searches for TXK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TXK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TXK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TXK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TXK gene:
Search GeneIP for patents involving TXK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TXK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TXK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TXK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TXK | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TXK | | OriGene 3'-UTR Clone for TXK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TXK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TXK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TXK | | OriGene Custom Protein Services for TXK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TXK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TXK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TXK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TXK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TXK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TXK |
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| | | | Search Tocris compounds for TXK |
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 | | | TXK Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXK |
|  |  |  | | | | ThermoFisher Antibodies for TXK |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXK |
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