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Aliases for TXK Gene

Aliases for TXK Gene

  • TXK Tyrosine Kinase 2 3
  • PTK4 Protein Tyrosine Kinase 4 2 3
  • Protein-Tyrosine Kinase 4 3 4
  • Resting Lymphocyte Kinase 3 4
  • EC 2.7.10.2 4 63
  • PTK4 3 4
  • RLK 3 4
  • Tyrosine Kinase 3
  • EC 2.7.10 63
  • PSCTK5 3
  • BTKL 3
  • TKL 3

External Ids for TXK Gene

Previous HGNC Symbols for TXK Gene

  • PTK4

Previous GeneCards Identifiers for TXK Gene

  • GC04M048145
  • GC04M048378
  • GC04M047918
  • GC04M047909
  • GC04M047763
  • GC04M047388

Summaries for TXK Gene

GeneCards Summary for TXK Gene

TXK (TXK Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TXK include behcet's disease. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FER.

UniProtKB/Swiss-Prot for TXK Gene

  • Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates Tyr-201 of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Gene Wiki entry for TXK Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TXK Gene

Genomics for TXK Gene

Regulatory Elements for TXK Gene

Genomic Location for TXK Gene

Chromosome:
4
Start:
48,066,393 bp from pter
End:
48,134,256 bp from pter
Size:
67,864 bases
Orientation:
Minus strand

Genomic View for TXK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TXK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TXK Gene

Proteins for TXK Gene

  • Protein details for TXK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42681-TXK_HUMAN
    Recommended name:
    Tyrosine-protein kinase TXK
    Protein Accession:
    P42681
    Secondary Accessions:
    • Q14220

    Protein attributes for TXK Gene

    Size:
    527 amino acids
    Molecular mass:
    61258 Da
    Quaternary structure:
    • Interacts with PARP1 and EEF1A1. Interacts with SH2D2A (By similarity).

    Three dimensional structures from OCA and Proteopedia for TXK Gene

neXtProt entry for TXK Gene

Proteomics data for TXK Gene at MOPED

Selected DME Specific Peptides for TXK Gene

Post-translational modifications for TXK Gene

  • Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to the up-regulation of IFN-gamma gene transcription.
  • The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TXK Gene

Domains & Families for TXK Gene

Gene Families for TXK Gene

Suggested Antigen Peptide Sequences for TXK Gene

Graphical View of Domain Structure for InterPro Entry

P42681

UniProtKB/Swiss-Prot:

TXK_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Domain:
  • Contains 1 protein kinase domain.
  • Contains 1 SH2 domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
genes like me logo Genes that share domains with TXK: view

Function for TXK Gene

Molecular function for TXK Gene

GENATLAS Biochemistry:
protein tyrosine kinase 4,non receptor type,SRC family,Tec subfamily
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by phosphorylation by FYN.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates Tyr-201 of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.

Enzyme Numbers (IUBMB) for TXK Gene

Gene Ontology (GO) - Molecular Function for TXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 11859127
GO:0001012 RNA polymerase II regulatory region DNA binding IDA 11859127
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 11859127
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with TXK: view
genes like me logo Genes that share phenotypes with TXK: view

Animal Models for TXK Gene

MGI Knock Outs for TXK:

Animal Model Products

miRNA for TXK Gene

miRTarBase miRNAs that target TXK

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXK

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TXK Gene

Localization for TXK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TXK Gene

Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TXK Gene COMPARTMENTS Subcellular localization image for TXK gene
Compartment Confidence
nucleus 5
plasma membrane 3
extracellular 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10523612
GO:0005737 cytoplasm IDA 10523612
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA --
genes like me logo Genes that share ontologies with TXK: view

Pathways & Interactions for TXK Gene

genes like me logo Genes that share pathways with TXK: view

SIGNOR curated interactions for TXK Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TXK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001816 cytokine production ISS --
GO:0001865 NK T cell differentiation IEA --
GO:0002250 adaptive immune response ISS --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 11859127
GO:0006366 transcription from RNA polymerase II promoter IDA 11859127
genes like me logo Genes that share ontologies with TXK: view

Drugs & Compounds for TXK Gene

(4) Drugs for TXK Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
salicylic acid Approved Pharma Channel blocker 136
Calcium Nutra 0
tyrosine Nutra 547

(2) Additional Compounds for TXK Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Phosphatidylinositol
genes like me logo Genes that share compounds with TXK: view

Transcripts for TXK Gene

Unigene Clusters for TXK Gene

TXK tyrosine kinase:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TXK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TXK Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
SP1: - - -
SP2:
SP3:
SP4: - -
SP5: -

Relevant External Links for TXK Gene

GeneLoc Exon Structure for
TXK
ECgene alternative splicing isoforms for
TXK

Expression for TXK Gene

mRNA expression in normal human tissues for TXK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TXK Gene

This gene is overexpressed in Whole Blood (x12.5), Spleen (x6.5), and Small Intestine - Terminal Ileum (x4.1).

Protein differential expression in normal tissues from HIPED for TXK Gene

This gene is overexpressed in Spleen (55.4) and Brain (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TXK Gene



SOURCE GeneReport for Unigene cluster for TXK Gene Hs.479669

mRNA Expression by UniProt/SwissProt for TXK Gene

P42681-TXK_HUMAN
Tissue specificity: Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential.
genes like me logo Genes that share expression patterns with TXK: view

Protein tissue co-expression partners for TXK Gene

Primer Products

In Situ Assay Products

Orthologs for TXK Gene

This gene was present in the common ancestor of animals.

Orthologs for TXK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TXK 35
  • 89.06 (n)
  • 88.8 (a)
TXK 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TXK 35
  • 87.73 (n)
  • 87.67 (a)
TXK 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Txk 35
  • 81.69 (n)
  • 82.89 (a)
Txk 16
Txk 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TXK 35
  • 99.43 (n)
  • 99.43 (a)
TXK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Txk 35
  • 81.56 (n)
  • 82.13 (a)
oppossum
(Monodelphis domestica)
Mammalia TXK 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 39 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TXK 35
  • 70.14 (n)
  • 66.41 (a)
TXK 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 44 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100534735 35
  • 62.99 (n)
  • 61.63 (a)
TXK 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Btk29A 37
  • 49 (a)
Btk29A 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F26E4.5 37
  • 31 (a)
kin-23 37
  • 35 (a)
kin-24 37
  • 25 (a)
spe-8 37
  • 31 (a)
T21G5.1 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
ManyToMany
Species with no ortholog for TXK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TXK Gene

ENSEMBL:
Gene Tree for TXK (if available)
TreeFam:
Gene Tree for TXK (if available)

Paralogs for TXK Gene

Paralogs for TXK Gene

genes like me logo Genes that share paralogs with TXK: view

Variants for TXK Gene

Sequence variations from dbSNP and Humsavar for TXK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_028368 -
VAR_028369 -
VAR_041869 -

Structural Variations from Database of Genomic Variants (DGV) for TXK Gene

Variant ID Type Subtype PubMed ID
esv259703 OTHER Complex 20981092
esv989923 CNV Insertion 20482838
esv2727537 CNV Deletion 23290073
esv2282150 CNV Deletion 18987734
esv2727538 CNV Deletion 23290073
dgv26e197 CNV Deletion 19546169
nsv292298 CNV Loss 16902084
esv1207473 CNV Deletion 17803354
nsv293505 CNV Loss 16902084
esv2727539 CNV Deletion 23290073
esv999712 CNV Deletion 20482838
esv1703195 CNV Deletion 17803354

Variation tolerance for TXK Gene

Residual Variation Intolerance Score: 51.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TXK Gene

HapMap Linkage Disequilibrium report
TXK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TXK Gene

Disorders for TXK Gene

MalaCards: The human disease database

(1) MalaCards diseases for TXK Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
behcet's disease
  • adamantiades-behcet disease
- elite association
Search TXK in MalaCards View complete list of genes associated with diseases

Relevant External Links for TXK

Genetic Association Database (GAD)
TXK
Human Genome Epidemiology (HuGE) Navigator
TXK
Tumor Gene Database (TGDB):
TXK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TXK
genes like me logo Genes that share disorders with TXK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TXK Gene

Publications for TXK Gene

  1. Proteomics shed light on the brassinosteroid signaling mechanisms. (PMID: 20004136) Tang W. … Wang Z.Y. (Curr. Opin. Plant Biol. 2010) 23 67
  2. Tec protein tyrosine kinase inhibits CD25 expression in human T- lymphocyte. (PMID: 19883687) Susaki K. … Ishida T. (Immunol. Lett. 2010) 23 67
  3. Molecular events in human T cells treated with diesel exhaust particles or formaldehyde that underlie their diminished interferon-gamma and interleukin-10 production. (PMID: 18849615) Sasaki Y. … Aiba S. (Int. Arch. Allergy Immunol. 2009) 23 67
  4. Self/nonself perception and recognition mechanisms in plants: a comparison of self-incompatibility and innate immunity. (PMID: 18346103) Sanabria N. … Dubery I. (New Phytol. 2008) 23 67
  5. Plant receptor-like serine threonine kinases: roles in signaling and plant defense. (PMID: 18393610) Afzal A.J. … Lightfoot D.A. (Mol. Plant Microbe Interact. 2008) 23 67

Products for TXK Gene

Sources for TXK Gene

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