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TXK Gene

protein-coding   GIFtS: 70
GCID: GC04M047984

TXK Tyrosine Kinase

(Previous name: PTK4 protein tyrosine kinase 4)
(Previous symbol: PTK4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TXK Tyrosine Kinase1 2     BTKL2 5
PTK41 2 3     PSCTK52
PTK4 Protein Tyrosine Kinase 41 2     TKL2
Protein-Tyrosine Kinase 42 3     Tyrosine Kinase2
Resting Lymphocyte Kinase2 3     Tyrosine-Protein Kinase TXK2
RLK2 3     EC 2.7.108
EC 2.7.10.23 8     

External Ids:    HGNC: 124341   Entrez Gene: 72942   Ensembl: ENSG000000749667   OMIM: 6000585   UniProtKB: P426813   

Export aliases for TXK gene to outside databases

Previous GC identifers: GC04M048145 GC04M048378 GC04M047918 GC04M047909 GC04M047763 GC04M047388


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TXK Gene:
TXK (TXK tyrosine kinase) is a protein-coding gene. Diseases associated with TXK include lipomatosis, and behcet's disease. GO annotations related to this gene include RNA polymerase II regulatory region DNA binding and non-membrane spanning protein tyrosine kinase activity. An important paralog of this gene is TEC.

UniProtKB/Swiss-Prot: TXK_HUMAN, P42681
Function: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune
response. Regulates the development, function and differentiation of conventional T-cells and nonconventional
NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead
to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to
TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream
pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its
localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the
endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT)
translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex
that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly
regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both
PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine
IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor

Gene Wiki entry for TXK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_006238.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TXK gene promoter:
         STAT1   AP-1   ATF-2   STAT1alpha   IRF-2   POU2F1   POU2F1a   c-Myb   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTXK promoter sequence
   Search Chromatin IP Primers for TXK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TXK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p12   Ensembl cytogenetic band:  4p12   HGNC cytogenetic band: 4p12

TXK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TXK gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M047984:  view genomic region     (about GC identifiers)

Start:
48,068,410 bp from pter      End:
48,136,273 bp from pter
Size:
67,864 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TXK_HUMAN, P42681 (See protein sequence)
Recommended Name: Tyrosine-protein kinase TXK  
Size: 527 amino acids; 61258 Da
Subunit: Interacts with PARP1 and EEF1A1. Interacts with SH2D2A (By similarity)
Caution: Unlike the other TEC subfamily members, TXK is activated independently of the activity of
phosphatidylinositol 3-kinase, consistent with its lack of a PH domain. Membrane association is performed through
palmitoylation at the N-terminus
1 PDB 3D structure from and Proteopedia for TXK:
2DM0 (3D)    
Secondary accessions: Q14220

Explore the universe of human proteins at neXtProt for TXK: NX_P42681

Explore proteomics data for TXK at MOPED

Post-translational modifications: 

  • Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to
    the up-regulation of IFN-gamma gene transcription1
  • The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TXK (P42681) (see all 8)
     TEFMENG  RDLAARN  KSDVWSFG  RLYRPHLA 


    See TXK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003319.2  
    ENSEMBL proteins: 
     ENSP00000264316   ENSP00000422139   ENSP00000423481   ENSP00000424070   ENSP00000422798  
    Reactome Protein details: P42681

    TXK Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TXK Protein
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals TXK Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TXK

    TXK Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TXK Antibodies
    Abcam antibodies for TXK
    Cloud-Clone Corp. Antibodies for TXK
    ThermoFisher Antibodies for TXK
    LSBio Antibodies in human, mouse, rat for TXK

    TXK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TXK
    Browse Enzo Life Sciences for kits & assays
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    Cloud-Clone Corp. CLIAs for TXK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SH2D: SH2 domain containing

    IUPHAR Guide to PHARMACOLOGY protein family classification: TXK tyrosine kinase
    Tec family

    Selected InterPro protein domains (see all 8):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR001452 SH3_domain
     IPR000719 Prot_kinase_dom
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry P42681

    ProtoNet protein and cluster: P42681

    3 Blocks protein domains:
    IPB000980 SH2 domain signature
    IPB001452 SH3 domain signature
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: TXK_HUMAN, P42681
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 1 SH2 domain
    Similarity: Contains 1 SH3 domain


    TXK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TXK_HUMAN, P42681
    Function: Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune
    response. Regulates the development, function and differentiation of conventional T-cells and nonconventional
    NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead
    to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to
    TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream
    pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its
    localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the
    endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT)
    translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex
    that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly
    regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both
    PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine
    IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme regulation: Activated by phosphorylation by FYN

         Genatlas biochemistry entry for TXK:
    protein tyrosine kinase 4,non receptor type,SRC family,Tec subfamily

         Enzyme Numbers (IUBMB): EC 2.7.10.21 2 EC 2.7.102

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001012RNA polymerase II regulatory region DNA binding IDA11859127
    GO:0004672protein kinase activity ----
    GO:0004713protein tyrosine kinase activity ----
    GO:0004715non-membrane spanning protein tyrosine kinase activity IEA--
    GO:0005515protein binding ----
         
    TXK for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TXK:
     Decreased substrate adherent c  Increased cell death HMECs cel 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Txk):
     hematopoietic system  immune system 

    TXK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Txktm1Pls for TXK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TXK
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TXK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TXK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TXK

    miRNA
    Products:
        
    miRTarBase miRNAs that target TXK:
    hsa-mir-26b-5p (MIRT029543)

    Block miRNA regulation of human, mouse, rat TXK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXK (see all 11):
    hsa-miR-668 hsa-miR-181c hsa-miR-571 hsa-miR-181a hsa-miR-181d hsa-miR-342-3p hsa-miR-19b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidTXK 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TXK
    Predesigned siRNA for gene silencing in human, mouse, rat TXK

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TXK

    Clone
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    OriGene clones in human, mouse for TXK (see all 8)
    OriGene ORF clones in mouse, rat for TXK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXK (NM_003328)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXK

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TXK
    Browse ESI BIO Cell Lines and PureStem Progenitors for TXK 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TXK_HUMAN, P42681: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Localizes in the
    vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the
    nucleus and enhances IFN-gamma gene transcription in T-cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    cytosol2
    extracellular2
    mitochondrion2
    cytoskeleton1
    endosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10523612
    GO:0005737cytoplasm IDA10523612
    GO:0005886plasma membrane IEA--

    TXK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TXK About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1ICos-ICosL Pathway in T-Helper Cell
    ICos-ICosL Pathway in T-Helper Cell0.66
    CD28 Signaling in T-Helper Cell0.66
    2Focal adhesion
    Focal Adhesion0.65
    3PI-3K cascade
    Fc epsilon receptor (FCERI) signaling0.64
    4Akt Signaling
    Tec Kinases Signaling0.55
    5Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
    FCERI mediated Ca+2 mobilization0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TXK
        ICos-ICosL Pathway in T-Helper Cell
    Sperm Motility
    CD28 Signaling in T-Helper Cell
    Tec Kinases Signaling
    Transendothelial Migration of Leukocytes

    1 BioSystems Pathway for TXK
        Focal Adhesion

    1 Reactome Pathway for TXK
        FCERI mediated Ca+2 mobilization


    1 Kegg Pathway  (Kegg details for TXK):
        Leukocyte transendothelial migration


    TXK for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TXK
    Interactions:

        GeneGlobe Interaction Network for TXK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TXK (P426812, 3 ENSP000002643164) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERBB2P046262, 3, ENSP000002695714MINT-74794 I2D: score=2 STRING: ENSP00000269571
    ERBB3P218602, 3, ENSP000002671014MINT-74795 I2D: score=2 STRING: ENSP00000267101
    CCR5P516813, ENSP000002923034I2D: score=1 STRING: ENSP00000292303
    CTLA4P164103, ENSP000003039394I2D: score=1 STRING: ENSP00000303939
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001816cytokine production ISS--
    GO:0001865NK T cell differentiation IEA--
    GO:0002250adaptive immune response ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA11859127

    TXK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TXK

    2 HMDB Compounds for TXK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    4 Novoseek inferred chemical compound relationships for TXK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 64 39 10523612 (2), 16809408 (2), 9761724 (2), 10224128 (2) (see all 24)
    phosphatidylinositol 25.1 2 10224128 (1), 9891083 (1)
    salicylic acid 21.7 3 11135117 (2)
    calcium 0 1 10224128 (1)



    TXK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TXK gene: 
    NM_003328.2  

    Unigene Cluster for TXK:

    TXK tyrosine kinase
    Hs.479669  [show with all ESTs]
    Unigene Representative Sequence: NM_003328
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264316(uc010igj.3 uc011bzj.2 uc003gxx.4) ENST00000514937
    ENST00000507351 ENST00000509681 ENST00000510457(uc003gxy.1) ENST00000506073

    miRNA
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    Block miRNA regulation of human, mouse, rat TXK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TXK (see all 11):
    hsa-miR-668 hsa-miR-181c hsa-miR-571 hsa-miR-181a hsa-miR-181d hsa-miR-342-3p hsa-miR-19b hsa-miR-19a
    SwitchGear 3'UTR luciferase reporter plasmidTXK 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TXK
    Predesigned siRNA for gene silencing in human, mouse, rat TXK
    Clone
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    OriGene clones in human, mouse for TXK (see all 8)
    OriGene ORF clones in mouse, rat for TXK
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TXK (NM_003328)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TXK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TXK
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TXK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXK
      QuantiTect SYBR Green Assays in human, mouse, rat TXK
      QuantiFast Probe-based Assays in human, mouse, rat TXK

    Additional mRNA sequence: 

    AK300141.1 AK307055.1 BC017829.1 L27071.1 

    9 DOTS entries:

    DT.100748682  DT.411527  DT.91662293  DT.91689321  DT.100707092  DT.121272929  DT.121272931  DT.95357800 
    DT.95362158 

    Selected AceView cDNA sequences (see all 36):

    AU135626 AU136430 AU137964 BX471176 AU137359 AU135099 BX380478 NM_003328 
    BX119536 BQ023054 AA765195 BI868877 AU156197 AU140073 BX370006 L27071 
    CB148756 BQ004606 BX369985 AU118976 BM562427 BX496104 BV202966 BG483797 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TXK    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:        -                                                                 -     -                                             
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                            -     -                           
    SP5:                                                                                                  -                           


    ECgene alternative splicing isoforms for TXK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TXK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCTCTGGG
    TXK Expression
    About this image


    TXK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Natural Killer Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             T-Cytotoxic Cells Thymus
     
     Placenta (Extraembryonic Tissues)
    TXK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TXK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479669

    UniProtKB/Swiss-Prot: TXK_HUMAN, P42681
    Tissue specificity: Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with
    IFN-gamma-producing potential

        Custom PCR Arrays for TXK
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TXK
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TXK
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    QuantiFast Probe-based Assays in human, mouse, rat TXK
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TXK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TXK gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Txk1 , 5 TXK tyrosine kinase1, 5 81.69(n)1
    82.89(a)1
      5 (38.44 cM)5
    221651  NM_013698.21  NP_038726.21 
     726959785 
    chicken
    (Gallus gallus)
    Aves TXK1 TXK tyrosine kinase 70.14(n)
    66.41(a)
      770387  XM_004936052.1  XP_004936109.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    44(a)
    many ↔ many
    GL343706.1(55330-58279)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005347351 tyrosine-protein kinase Tec-like 62.99(n)
    61.63(a)
      100534735  XM_003201244.2  XP_003201292.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Btk29A3 male genital morphogenesis (sensu
    Holometabola) more
    49(a)   29A1   --


    ENSEMBL Gene Tree for TXK (if available)
    TreeFam Gene Tree for TXK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TXK gene
    TEC2  CSK2  FER2  ITK2  FES2  DSTYK2  MATK2  BMX2  
    BTK2  
    Selected SIMAP similar genes for TXK using alignment to 9 protein entries:     TXK_HUMAN (see all proteins) (see all similar genes):
    BTK kinase deficient isoform 4    TEC    tec    ITK    BTK kinase deficient isoform 2    EPHA4
    BTK kinase deficient isoform 6    BTK    EPHA2    NLK    DKFZp686M05208    EGFR
    ERBB2    ABL1    CDK10    DDR1    MAPK7    EPHA6

    TXK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TXK (see all 1344)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483491091,2
    --48067941(+) GTAAAC/TTCATG 1 -- ds50010--------
    rs64476141,2
    C,F,A,H--48067957(+) TGAATC/TGAGGT 1 -- ds500131Minor allele frequency- T:0.49NS EA NA WA CSA 2875
    rs1403088491,2
    --48068075(+) TTTTGA/TGACAG 1 -- ds50010--------
    rs1828507231,2
    --48068108(+) TGGAGC/TGCAGT 1 -- ds50010--------
    rs1868078931,2
    --48068134(+) CACTGA/CAGCCT 1 -- ds50010--------
    rs1504480471,2
    C--48068216(+) GCTTT-/TT    
       TTTTC
    TTTTT
    1 -- ds50010--------
    rs800858371,2
    C,F--48068338(+) TAGGCA/GTGAGC 1 -- ds50012Minor allele frequency- G:0.04NA 122
    rs1160120341,2
    F--48068401(+) CCTCTT/AGTAAC 1 -- ds50011Minor allele frequency- A:0.05WA 118
    rs778378521,2
    F--48068446(+) TGTCAC/TTGATA 1 -- ut310--------
    rs1900453381,2
    --48068580(+) GACAGG/TACGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TXK (48068410 - 48136273 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TXK (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv999712CNV Deletion20482838
    esv1703195CNV Deletion17803354
    esv2727537CNV Deletion23290073
    esv2727539CNV Deletion23290073
    esv2282150CNV Deletion18987734
    dgv26e197CNV Deletion19546169
    esv1207473CNV Deletion17803354
    esv2727538CNV Deletion23290073
    esv989923CNV Insertion20482838
    nsv293505CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600058    OMIM disorders: --

    12 diseases for TXK:    
    About MalaCards
    lipomatosis    behcet's disease    agammaglobulinemia    gastrointestinal stromal tumor
    dermatitis    atopic dermatitis    chronic myeloid leukemia    myeloid leukemia
    inflammatory bowel disease    renal cell carcinoma    leukemia    lung cancer

    4 diseases from the University of Copenhagen DISEASES database for TXK:
    Gastrointestinal stromal tumor     Lung cancer     Leukemia     Renal cell carcinoma

    TXK for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for TXK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    behcet disease 47.4 2 16809408 (1), 15654836 (1)
    dermatitis atopic 32.4 4 15008986 (2), 15654836 (1), 18027204 (1)
    skin lesion 29.4 5 15654836 (4), 15008986 (1)

    Genetic Association Database (GAD): TXK
    Human Genome Epidemiology (HuGE) Navigator: TXK (6 documents)
    Tumor Gene Database (TGDB): TXK

    Export disorders for TXK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TXK gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with TXK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12. (PubMed id 7951233)1, 2, 3 Haire R.N.... Litman G.W. (Hum. Mol. Genet. 1994)
    2. Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes. (PubMed id 10523612)1, 2, 9 Kashiwakura J.... Sakane T. (J. Exp. Med. 1999)
    3. Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription. (PubMed id 11859127)1, 2, 9 Takeba Y.... Suzuki N. (J. Immunol. 2002)
    4. Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene. (PubMed id 8632917)1, 2, 9 Ohta Y....Litman G.W. (Oncogene 1996)
    5. Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4. (PubMed id 9813138)1, 2, 9 Schneider H.... Rudd C.E. (Biochem. Biophys. Res. Commun. 1998)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site. (PubMed id 12081135)1, 2 Kashiwakura J.... Toyoshima S. (Biol. Pharm. Bull. 2002)
    10. A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12. (PubMed id 7528718)1, 3 Spritz R.A....Moir D.T. (Genomics 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7294 HGNC: 12434 AceView: TXK Ensembl:ENSG00000074966 euGenes: HUgn7294
    ECgene: TXK Kegg: 7294 H-InvDB: TXK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TXK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TXK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TXK gene:
    Search GeneIP for patents involving TXK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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