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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TWSG1 Gene

protein-coding   GIFtS: 52
GCID: GC18P009324

Twisted Gastrulation BMP Signaling Modulator 1

(Previous name: twisted gastrulation homolog 1 (Drosophila))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Twisted Gastrulation BMP Signaling Modulator 11
TSG2 3 5
Twisted Gastrulation Homolog 1 (Drosophila)1 2
Twisted Gastrulation Protein Homolog 12

External Ids:    HGNC: 124291   Entrez Gene: 570452   Ensembl: ENSG000001287917   OMIM: 6050495   UniProtKB: Q9GZX93   

Export aliases for TWSG1 gene to outside databases

Previous GC identifers: GC00U990679 GC18P009391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TWSG1 Gene: 
TWSG1 (twisted gastrulation BMP signaling modulator 1) is a protein-coding gene. Diseases associated with TWSG1 include holoprosencephaly.

UniProtKB/Swiss-Prot: TWSG1_HUMAN, Q9GZX9
Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary
complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the
anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases
BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte
differentiation. May play a role in thymocyte development (By similarity)

Gene Wiki entry for TWSG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010859.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TWSG1 gene promoter:
         TBP   STAT5B   ISGF-3   STAT5A   AP-2gamma   HNF-1A   HNF-1   TFIID   AP-2beta   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTWSG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TWSG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TWSG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.3

TWSG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TWSG1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P009324:  view genomic region     (about GC identifiers)

Start:
9,334,765 bp from pter      End:
9,402,418 bp from pter
Size:
67,654 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TWSG1_HUMAN, Q9GZX9 (See protein sequence)
Recommended Name: Twisted gastrulation protein homolog 1 precursor  
Size: 223 amino acids; 25017 Da
Subunit: Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7
(By similarity)
Subcellular location: Secreted (By similarity)
Developmental stage: Expressed in brain throughout development
Sequence caution: Sequence=BAB55246.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B2RE08 D3DUH9 Q8NBI7 Q96K46
Alternative splicing: 2 isoforms:  Q9GZX9-1   Q9GZX9-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TWSG1: NX_Q9GZX9

Explore proteomics data for TWSG1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZX9

  • TWSG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TWSG1 Protein Expression
    REFSEQ proteins: NP_065699.1  
    ENSEMBL proteins: 
     ENSP00000463331   ENSP00000262120   ENSP00000464458  

    Human Recombinant Protein Products for TWSG1: 
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    Novus Biologicals TWSG1 Proteins
    Novus Biologicals TWSG1 Lysate
    Sino Biological Recombinant Protein for TWSG1
    Sino Biological Cell Lysate for TWSG1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TWSG1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    TWSG1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006761 Tsg

    Graphical View of Domain Structure for InterPro Entry Q9GZX9

    ProtoNet protein and cluster: Q9GZX9

    UniProtKB/Swiss-Prot: TWSG1_HUMAN, Q9GZX9
    Domain: The N-terminal domain is sufficient to interact with BMP4 (By similarity)
    Similarity: Belongs to the twisted gastrulation protein family


    TWSG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TWSG1_HUMAN, Q9GZX9
    Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary
    complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the
    anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases
    BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte
    differentiation. May play a role in thymocyte development (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TWSG1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TWSG1:
     G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a 

         15/19 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Twsg1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  nervous system 

    TWSG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TWSG1: Twsg1tm1Nosa Twsg1tm1Dgen Twsg1tm1.1Mboc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TWSG1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TWSG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TWSG1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TWSG1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TWSG1
    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TWSG1 (see all 15):
    hsa-miR-3671 hsa-miR-136 hsa-miR-548am hsa-miR-7-2* hsa-miR-606 hsa-miR-548aa hsa-miR-20b* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTWSG1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWSG1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TWSG1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for TWSG1 (Q9GZX93 ENSP000002621204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRDQ9H2X03, ENSP000002046044I2D: score=3 STRING: ENSP00000204604
    BMP4P126443, ENSP000002454514I2D: score=2 STRING: ENSP00000245451
    BMP1P134973, ENSP000003057144I2D: score=1 STRING: ENSP00000305714
    EEF2P136393I2D: score=5 
    SIRT4Q9Y6E73I2D: score=3 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001707mesoderm formation IEA--
    GO:0007435salivary gland morphogenesis IEA--
    GO:0009790embryo development ----
    GO:0009888tissue development ----

    TWSG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TWSG1

    Search CenterWatch for drugs/clinical trials and news about TWSG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TWSG1 gene: 
    NM_020648.5  

    Unigene Cluster for TWSG1:

    Twisted gastrulation homolog 1 (Drosophila)
    Hs.514685  [show with all ESTs]
    Unigene Representative Sequence: NM_020648
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583147 ENST00000262120(uc002knz.3 uc002koa.3) ENST00000581641

    miRNA
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    8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate TWSG1 (see all 15):
    hsa-miR-3671 hsa-miR-136 hsa-miR-548am hsa-miR-7-2* hsa-miR-606 hsa-miR-548aa hsa-miR-20b* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTWSG1 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TWSG1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TWSG1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TWSG1

    Additional mRNA sequence: 

    AF196834.1 AF294628.1 AJ297391.1 AK027629.1 AK075550.1 AK315751.1 BC020490.1 

    7 DOTS entries:

    DT.313720  DT.97858870  DT.92434329  DT.100788882  DT.121106537  DT.95171956  DT.95171963 

    24/209 AceView cDNA sequences (see all 209):

    BM053044 BP342527 AI478573 CK903960 AA329449 AI670046 AI700813 BM925839 
    AA236064 CF135658 AW591873 AL711102 AJ297391 AI018381 AI129471 BG939962 
    AA235953 AI087263 BU631678 BM683178 BQ015603 AA235906 N91767 CF529431 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TWSG1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                                -                 -                       -               
    SP2:                                -                 -     -     -           -               
    SP3:                                -                 -     -     -                           
    SP4:                          -     -     -           -     -     -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TWSG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TWSG1 expression in normal human tissues (normalized intensities)      TWSG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTTCTAA
    TWSG1 Expression
    About this image


    TWSG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             huvec   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Umbilical Cord (Extraembryonic Tissues)
             huvec   
     
     Blood (Cardiovascular System)
             blood outgrowth endothelial cell   

    See TWSG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TWSG1

    SOURCE GeneReport for Unigene cluster: Hs.514685
        SABiosciences Custom PCR Arrays for TWSG1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWSG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TWSG1 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Twsg11 , 5 twisted gastrulation homolog 1 (Drosophila)1, 5 84.68(n)1
    93.69(a)1
      17 (35.26 cM)5
    659601  NM_023053.31  NP_075540.11 
     659230665 
    chicken
    (Gallus gallus)
    Aves TWSG11 twisted gastrulation homolog 1 (Drosophila) 82.24(n)
    93.46(a)
      374024  NM_204198.1  NP_989529.1 
    lizard
    (Anolis carolinensis)
    Reptilia TWSG16
    --
    Uncharacterized protein
    76(a)
    41(a)
    1 ↔ 1
    possible ortholog
    5(805980-824124)
    GL343776.1(533-2765)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.7782 Xenopus laevis twisted gastrulation protein mRNA, complete more 80.56(n)    AF279246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsga2 twisted gastrulation a 77.98(n)   84037  AF261692.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cv1 crossveinless 48(n)
    42(a)
      44510  NM_080525.2  NP_536786.1 


    ENSEMBL Gene Tree for TWSG1 (if available)
    TreeFam Gene Tree for TWSG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1350 SNPs in TWSG1 are shown (see all 1350)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733999171,2
    C--9296626(+) AACCAC/TGCTGT 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1906836941,2
    --9296962(+) TGGGTA/GTACCC 1 -- us2k10--------
    rs1842237381,2
    --9297131(+) GATTTA/CCCAGC 1 -- us2k10--------
    rs1887708371,2
    --9297139(+) AGCATA/GAGGGT 1 -- us2k10--------
    rs1921742051,2
    --9297197(+) TGGTCC/TAGCGG 1 -- us2k10--------
    rs1828917761,2
    --9297390(+) GCCAGC/GCGTGG 1 -- us2k10--------
    rs1872368121,2
    --9297507(+) CCTGGG/TGAGAG 1 -- us2k10--------
    rs1916843571,2
    --9297587(+) TCAATA/GTTTTT 1 -- us2k10--------
    rs72425931,2
    C,F,H--9297639(+) ACCTCC/TGCGCC 1 -- us2k16Minor allele frequency- T:0.08NS EA WA NA 646
    rs1390609831,2
    --9297689(+) AGCTCC/GGATGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TWSG1 (9334765 - 9402418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TWSG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2716769CNV Deletion23290073
    esv269088CNV Insertion20981092
    esv274543CNV Insertion20981092
    nsv507859CNV Insertion20534489
    nsv909365CNV Loss21882294
    esv7261CNV Loss19470904
    dgv55n6CNV Loss16902084
    nsv833585CNV Gain+Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605049    OMIM disorders: --

    2 diseases for TWSG1:    About MalaCards
    holoprosencephaly    

    1 disease from the University of Copenhagen DISEASES database for TWSG1:
    Holoprosencephaly

    TWSG1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TWSG1 (1 document)

    Export disorders for TWSG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TWSG1 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with TWSG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. (PubMed id 11260715)1, 2, 3 Scott I.C....Greenspan D.S. (2001)
    2. Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation. (PubMed id 11420619)1, 2, 9 Graf D.... Merkenschlager M. (2001)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. GWAS of dental caries patterns in the permanent dentit ion. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (2013)
    6. Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly. (PubMed id 21227728)1 Kauvar E.F....Muenke M. (2011)
    7. Identification of TWSG1 as a second novel erythroid r egulator of hepcidin expression in murine and human cells. (PubMed id 19414861)1 Tanno T....Miller J.L. (2009)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. (PubMed id 17164348)1 Tzachanis D....Boussiotis V.A. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57045 HGNC: 12429 AceView: TWSG1 Ensembl:ENSG00000128791 euGenes: HUgn57045
    ECgene: TWSG1 H-InvDB: TWSG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TWSG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TWSG1 gene:
    Search GeneIP for patents involving TWSG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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