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TWSG1 Gene

protein-coding   GIFtS: 53
GCID: GC18P009324

Twisted Gastrulation BMP Signaling Modulator 1

(Previous name: twisted gastrulation homolog 1 (Drosophila))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Twisted Gastrulation BMP Signaling Modulator 11 2
TSG2 3 5
Twisted Gastrulation Homolog 1 (Drosophila)1
Twisted Gastrulation Homolog 12
Twisted Gastrulation Protein Homolog 12

External Ids:    HGNC: 124291   Entrez Gene: 570452   Ensembl: ENSG000001287917   OMIM: 6050495   UniProtKB: Q9GZX93   

Export aliases for TWSG1 gene to outside databases

Previous GC identifers: GC00U990679 GC18P009391


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TWSG1 Gene:
TWSG1 (twisted gastrulation BMP signaling modulator 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: TWSG1_HUMAN, Q9GZX9
Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary
complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the
anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases
BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte
differentiation. May play a role in thymocyte development (By similarity)

Gene Wiki entry for TWSG1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000018.9  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the TWSG1 gene promoter:
         TBP   STAT5B   ISGF-3   STAT5A   AP-2gamma   HNF-1A   HNF-1   TFIID   AP-2beta   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTWSG1 promoter sequence
   Search Chromatin IP Primers for TWSG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TWSG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3   Ensembl cytogenetic band:  18p11.22   HGNC cytogenetic band: 18p11.3

TWSG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TWSG1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P009324:  view genomic region     (about GC identifiers)

Start:
9,334,765 bp from pter      End:
9,402,418 bp from pter
Size:
67,654 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TWSG1_HUMAN, Q9GZX9 (See protein sequence)
Recommended Name: Twisted gastrulation protein homolog 1 precursor  
Size: 223 amino acids; 25017 Da
Subunit: Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7
(By similarity)
Developmental stage: Expressed in brain throughout development
Sequence caution: Sequence=BAB55246.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B2RE08 D3DUH9 Q8NBI7 Q96K46
Alternative splicing: 2 isoforms:  Q9GZX9-1   Q9GZX9-2   (No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for TWSG1: NX_Q9GZX9

Explore proteomics data for TWSG1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys192
  • Glycosylation2 at Asn52, Asn81
  • Modification sites at PhosphoSitePlus

  • See TWSG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065699.1  
    ENSEMBL proteins: 
     ENSP00000463331   ENSP00000262120   ENSP00000464458  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006761 Tsg

    Graphical View of Domain Structure for InterPro Entry Q9GZX9

    ProtoNet protein and cluster: Q9GZX9

    UniProtKB/Swiss-Prot: TWSG1_HUMAN, Q9GZX9
    Domain: The N-terminal domain is sufficient to interact with BMP4 (By similarity)
    Similarity: Belongs to the twisted gastrulation protein family


    Find genes that share domains with TWSG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TWSG1_HUMAN, Q9GZX9
    Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary
    complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the
    anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases
    BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte
    differentiation. May play a role in thymocyte development (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TWSG1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TWSG1:
     G0/1 arrest  Increased G1 DNA content  Increased HPV18 LCR reporter a 

         Selected MGI mutant phenotypes (inferred from 6 alleles(MGI details for Twsg1) (see all 19):
     behavior/neurological  cardiovascular system  cellular  craniofacial  digestive/alimentary 
     embryogenesis  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  hematopoietic system 
     homeostasis/metabolism  immune system  limbs/digits/tail  mortality/aging  nervous system 

    Find genes that share phenotypes with TWSG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TWSG1: Twsg1tm1Nosa Twsg1tm1Dgen Twsg1tm1.1Mboc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TWSG1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TWSG1

    miRNA
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    miRTarBase miRNAs that target TWSG1:
    hsa-mir-577 (MIRT040515), hsa-mir-124-3p (MIRT022445)

    Block miRNA regulation of human, mouse, rat TWSG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TWSG1 (see all 15):
    hsa-miR-3671 hsa-miR-136 hsa-miR-548am hsa-miR-7-2* hsa-miR-606 hsa-miR-548aa hsa-miR-20b* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTWSG1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TWSG1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TWSG1_HUMAN, Q9GZX9: Secreted (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular3
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with TWSG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TWSG1
    Interactions:

        GeneGlobe Interaction Network for TWSG1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for TWSG1 (Q9GZX93 ENSP000002621204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHRDQ9H2X03, ENSP000002046044I2D: score=3 STRING: ENSP00000204604
    BMP4P126443, ENSP000002454514I2D: score=2 STRING: ENSP00000245451
    BMP1P134973, ENSP000003057144I2D: score=1 STRING: ENSP00000305714
    EEF2P136393I2D: score=5 
    SIRT4Q9Y6E73I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001503ossification IEA--
    GO:0001707mesoderm formation IEA--
    GO:0007435salivary gland morphogenesis IEA--
    GO:0009790embryo development ----
    GO:0009888tissue development ----

    Find genes that share ontologies with TWSG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TWSG1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TWSG1 gene: 
    NM_020648.5  

    Unigene Cluster for TWSG1:

    Twisted gastrulation homolog 1 (Drosophila)
    Hs.514685  [show with all ESTs]
    Unigene Representative Sequence: NM_020648
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583147 ENST00000262120(uc002knz.3 uc002koa.3) ENST00000581641

    miRNA
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    Block miRNA regulation of human, mouse, rat TWSG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TWSG1 (see all 15):
    hsa-miR-3671 hsa-miR-136 hsa-miR-548am hsa-miR-7-2* hsa-miR-606 hsa-miR-548aa hsa-miR-20b* hsa-miR-664
    SwitchGear 3'UTR luciferase reporter plasmidTWSG1 3' UTR sequence
    Inhib. RNA
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    OriGene qPCR primer pairs and template standards for TWSG1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TWSG1
      QuantiTect SYBR Green Assays in human, mouse, rat TWSG1
      QuantiFast Probe-based Assays in human, mouse, rat TWSG1

    Additional mRNA sequence: 

    AF196834.1 AF294628.1 AJ297391.1 AK027629.1 AK075550.1 AK315751.1 BC020490.1 

    7 DOTS entries:

    DT.313720  DT.97858870  DT.92434329  DT.100788882  DT.121106537  DT.95171956  DT.95171963 

    Selected AceView cDNA sequences (see all 209):

    AL711102 BM719230 AA236064 AA235906 BP343234 AJ297391 AA235953 BG939962 
    BM683178 CK903960 AA905905 CF135658 BM053044 AI129471 BP342527 BM925839 
    AI478573 CF529431 AA329449 BU631678 CR608086 AI087263 AI018381 N91767 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TWSG1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
    SP1:                                -                 -                       -               
    SP2:                                -                 -     -     -           -               
    SP3:                                -                 -     -     -                           
    SP4:                          -     -     -           -     -     -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TWSG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TWSG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTTCTAA
    TWSG1 Expression
    About this image


    TWSG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Fibroblasts (Uncategorized)
     
     Uterus (Reproductive System)
    TWSG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TWSG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514685
        Custom PCR Arrays for TWSG1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWSG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TWSG1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Twsg11 , 5 twisted gastrulation homolog 1 (Drosophila)1, 5 84.68(n)1
    93.69(a)1
      17 (35.26 cM)5
    659601  NM_023053.31  NP_075540.11 
     659230665 
    chicken
    (Gallus gallus)
    Aves TWSG11 twisted gastrulation homolog 1 (Drosophila) 82.24(n)
    93.46(a)
      374024  NM_204198.1  NP_989529.1 
    lizard
    (Anolis carolinensis)
    Reptilia TWSG16
    twisted gastrulation BMP signaling modulator 1
    76(a)
    1 ↔ 1
    5(805980-824124)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.7782 Xenopus laevis twisted gastrulation protein mRNA, complete more 80.56(n)    AF279246.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tsga2 twisted gastrulation a 77.98(n)   84037  AF261692.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tsg1 twisted gastrulation 45.71(n)
    39.11(a)
      32160  NM_078580.4  NP_511135.1 


    ENSEMBL Gene Tree for TWSG1 (if available)
    TreeFam Gene Tree for TWSG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TWSG1 (see all 1350)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs733999171,2
    C--9296626(+) AACCAC/TGCTGT 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1906836941,2
    --9296962(+) TGGGTA/GTACCC 1 -- us2k10--------
    rs1842237381,2
    --9297131(+) GATTTA/CCCAGC 1 -- us2k10--------
    rs1887708371,2
    --9297139(+) AGCATA/GAGGGT 1 -- us2k10--------
    rs1921742051,2
    --9297197(+) TGGTCC/TAGCGG 1 -- us2k10--------
    rs1828917761,2
    --9297390(+) GCCAGC/GCGTGG 1 -- us2k10--------
    rs1872368121,2
    --9297507(+) CCTGGG/TGAGAG 1 -- us2k10--------
    rs1916843571,2
    --9297587(+) TCAATA/GTTTTT 1 -- us2k10--------
    rs72425931,2
    C,F,H--9297639(+) ACCTCC/TGCGCC 1 -- us2k16Minor allele frequency- T:0.08NS EA WA NA 646
    rs1390609831,2
    --9297689(+) AGCTCC/GGATGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TWSG1 (9334765 - 9402418 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TWSG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716769CNV Deletion23290073
    esv269088CNV Insertion20981092
    esv274543CNV Insertion20981092
    nsv507859CNV Insertion20534489
    nsv909365CNV Loss21882294
    esv7261CNV Loss19470904
    dgv55n6CNV Loss16902084
    nsv833585CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605049    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TWSG1:
    Holoprosencephaly

    Find genes that share disorders with TWSG1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: TWSG1 (1 document)

    Export disorders for TWSG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TWSG1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with TWSG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. (PubMed id 11260715)1, 2, 3 Scott I.C....Greenspan D.S. (Nature 2001)
    2. Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation. (PubMed id 11420619)1, 2, 9 Graf D.... Merkenschlager M. (Mamm. Genome 2001)
    3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation. (PubMed id 23641068)1 Heinke J....Moser M. (J. Cell. Sci. 2013)
    6. GWAS of dental caries patterns in the permanent dentition. (PubMed id 23064961)1 Shaffer J.R....Marazita M.L. (J. Dent. Res. 2013)
    7. Minimal evidence for a direct involvement of twisted gastrulation homolog 1 (TWSG1) gene in human holoprosencephaly. (PubMed id 21227728)1 Kauvar E.F....Muenke M. (Mol. Genet. Metab. 2011)
    8. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. (PubMed id 19414861)1 Tanno T....Miller J.L. (Blood 2009)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. Twisted gastrulation (Tsg) is regulated by Tob and enhances TGF-beta signaling in activated T lymphocytes. (PubMed id 17164348)1 Tzachanis D....Boussiotis V.A. (Blood 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57045 HGNC: 12429 AceView: TWSG1 Ensembl:ENSG00000128791 euGenes: HUgn57045
    ECgene: TWSG1 H-InvDB: TWSG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TWSG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TWSG1 gene:
    Search GeneIP for patents involving TWSG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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