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Aliases for TWSG1 Gene

Aliases for TWSG1 Gene

  • Twisted Gastrulation BMP Signaling Modulator 1 2 3
  • TSG 3 4 6
  • Twisted Gastrulation Homolog 1 (Drosophila) 2
  • Twisted Gastrulation Protein Homolog 1 3
  • Twisted Gastrulation Homolog 1 3

External Ids for TWSG1 Gene

Previous GeneCards Identifiers for TWSG1 Gene

  • GC00U990679
  • GC18P009391

Summaries for TWSG1 Gene

GeneCards Summary for TWSG1 Gene

TWSG1 (Twisted Gastrulation BMP Signaling Modulator 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TWSG1 Gene

  • May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).

Gene Wiki entry for TWSG1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TWSG1 Gene

Genomics for TWSG1 Gene

Regulatory Elements for TWSG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TWSG1 Gene

Start:
9,334,767 bp from pter
End:
9,402,420 bp from pter
Size:
67,654 bases
Orientation:
Plus strand

Genomic View for TWSG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TWSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TWSG1 Gene

Proteins for TWSG1 Gene

  • Protein details for TWSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZX9-TWSG1_HUMAN
    Recommended name:
    Twisted gastrulation protein homolog 1
    Protein Accession:
    Q9GZX9
    Secondary Accessions:
    • B2RE08
    • D3DUH9
    • Q8NBI7
    • Q96K46

    Protein attributes for TWSG1 Gene

    Size:
    223 amino acids
    Molecular mass:
    25017 Da
    Quaternary structure:
    • Interacts with CHRD and BMP4. This interaction enhances CHRD/BMP4 complex formation. Interacts with BMP7 (By similarity).
    SequenceCaution:
    • Sequence=BAB55246.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for TWSG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TWSG1 Gene

Proteomics data for TWSG1 Gene at MOPED

Post-translational modifications for TWSG1 Gene

  • Ubiquitination at Lys192
  • Glycosylation at Asn52 and Asn81
  • Modification sites at PhosphoSitePlus

Other Protein References for TWSG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TWSG1 Gene

Domains for TWSG1 Gene

Protein Domains for TWSG1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TWSG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9GZX9

UniProtKB/Swiss-Prot:

TWSG1_HUMAN :
  • Q9GZX9
Domain:
  • The N-terminal domain is sufficient to interact with BMP4.
Family:
  • Belongs to the twisted gastrulation protein family.
genes like me logo Genes that share domains with TWSG1: view

No data available for Gene Families for TWSG1 Gene

Function for TWSG1 Gene

Molecular function for TWSG1 Gene

UniProtKB/Swiss-Prot Function: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity).

Gene Ontology (GO) - Molecular Function for TWSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TWSG1: view
genes like me logo Genes that share phenotypes with TWSG1: view

Animal Models for TWSG1 Gene

MGI Knock Outs for TWSG1:

Animal Model Products

CRISPR Products

miRNA for TWSG1 Gene

miRTarBase miRNAs that target TWSG1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TWSG1 Gene

Localization for TWSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TWSG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TWSG1 Gene COMPARTMENTS Subcellular localization image for TWSG1 gene
Compartment Confidence
extracellular 3
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TWSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TWSG1: view

Pathways for TWSG1 Gene

SuperPathways for TWSG1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TWSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification IEA --
GO:0001707 mesoderm formation IEA --
GO:0007435 salivary gland morphogenesis IEA --
GO:0009888 tissue development --
GO:0030097 hemopoiesis IEA --
genes like me logo Genes that share ontologies with TWSG1: view

No data available for Pathways by source for TWSG1 Gene

Transcripts for TWSG1 Gene

Unigene Clusters for TWSG1 Gene

Twisted gastrulation homolog 1 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TWSG1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TWSG1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - -
SP5:
SP6: -

Relevant External Links for TWSG1 Gene

GeneLoc Exon Structure for
TWSG1
ECgene alternative splicing isoforms for
TWSG1

Expression for TWSG1 Gene

mRNA expression in normal human tissues for TWSG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TWSG1 Gene

SOURCE GeneReport for Unigene cluster for TWSG1 Gene Hs.514685

genes like me logo Genes that share expressions with TWSG1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TWSG1 Gene

Orthologs for TWSG1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TWSG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TWSG1 35
  • 99.85 (n)
  • 99.55 (a)
TWSG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TWSG1 35
  • 90.13 (n)
  • 95.07 (a)
TWSG1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TWSG1 35
  • 91.03 (n)
  • 95.52 (a)
TWSG1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Twsg1 35
  • 84.68 (n)
  • 93.69 (a)
Twsg1 16
Twsg1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TWSG1 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TWSG1 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Twsg1 35
  • 85.14 (n)
  • 94.14 (a)
chicken
(Gallus gallus)
Aves TWSG1 35
  • 82.24 (n)
  • 93.46 (a)
TWSG1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TWSG1 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.778 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1743 35
twsg1 35
  • 70.34 (n)
  • 78.44 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1024 35
zebrafish
(Danio rerio)
Actinopterygii tsga 35
twsg1a 35
  • 68.55 (n)
  • 72.17 (a)
twsg1a 36
  • 71 (a)
OneToMany
twsg1b 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta cv 36
  • 31 (a)
OneToMany
srw 36
  • 35 (a)
OneToMany
tsg 35
  • 45.71 (n)
  • 39.11 (a)
tsg 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToOne
Species with no ortholog for TWSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TWSG1 Gene

ENSEMBL:
Gene Tree for TWSG1 (if available)
TreeFam:
Gene Tree for TWSG1 (if available)

Paralogs for TWSG1 Gene

No data available for Paralogs for TWSG1 Gene

Variants for TWSG1 Gene

Sequence variations from dbSNP and Humsavar for TWSG1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs7846 -- 9,400,703(+) TTTTA(A/G)AATCT utr-variant-3-prime
rs13285 -- 9,400,424(+) GGTGT(C/T)GCTGA utr-variant-3-prime
rs365200 -- 9,343,187(-) CATTT(C/T)CTAGT intron-variant
rs369344 -- 9,363,044(-) ACTTA(A/G)GAAGG intron-variant
rs385407 -- 9,342,914(+) ctgaa(C/T)acaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TWSG1 Gene

Variant ID Type Subtype PubMed ID
nsv909365 CNV Loss 21882294
esv2716769 CNV Deletion 23290073
dgv55n6 CNV Loss 16902084
esv7261 CNV Loss 19470904
nsv507859 CNV Insertion 20534489
esv274543 CNV Insertion 20981092
esv269088 CNV Insertion 20981092
nsv833585 CNV Gain+Loss 17160897

Relevant External Links for TWSG1 Gene

HapMap Linkage Disequilibrium report
TWSG1
Human Gene Mutation Database (HGMD)
TWSG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TWSG1 Gene

Disorders for TWSG1 Gene

(1) University of Copenhagen DISEASES for TWSG1 Gene

Relevant External Links for TWSG1

Human Genome Epidemiology (HuGE) Navigator
TWSG1
genes like me logo Genes that share disorders with TWSG1: view

No data available for UniProtKB/Swiss-Prot for TWSG1 Gene

Publications for TWSG1 Gene

  1. Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation. (PMID: 11420619) Graf D. … Merkenschlager M. (Mamm. Genome 2001) 3 4 23
  2. Homologues of Twisted gastrulation are extracellular cofactors in antagonism of BMP signalling. (PMID: 11260715) Scott I.C. … Greenspan D.S. (Nature 2001) 2 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Biglycan is a new extracellular component of the Chordin-BMP4 signaling pathway. (PMID: 15775969) Moreno M. … LarraA-n J. (EMBO J. 2005) 3

Products for TWSG1 Gene

Sources for TWSG1 Gene

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