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TWISTNB Gene

protein-coding   GIFtS: 51
GCID: GC07M019701

TWIST Neighbor

  See TWISTNB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TWIST Neighbor1 2
Twist Neighbor Protein2 3
DNA-Directed RNA Polymerase I Subunit RPA432

External Ids:    HGNC: 180271   Entrez Gene: 2218302   Ensembl: ENSG000001058497   OMIM: 6083125   UniProtKB: Q3B7263   

Export aliases for TWISTNB gene to outside databases

Previous GC identifers: GC07M019380 GC07M019482 GC07M019508


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TWISTNB Gene:
TWISTNB (TWIST neighbor) is a protein-coding gene. Diseases associated with TWISTNB include acrocephalosyndactylia. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot: RPA43_HUMAN, Q3B726
Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through
its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TWISTNB gene promoter:
         Max1   ISGF-3   p53   GCNF   E4BP4   E47   GCNF-1   GCNF-2   c-Myc   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTWISTNB promoter sequence
   Search Chromatin IP Primers for TWISTNB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TWISTNB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p21.1   Ensembl cytogenetic band:  7p21.1   HGNC cytogenetic band: 7p21.1

TWISTNB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TWISTNB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M019701:  view genomic region     (about GC identifiers)

Start:
19,735,085 bp from pter      End:
19,748,710 bp from pter
Size:
13,626 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 19,786,489-19,800,065     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RPA43_HUMAN, Q3B726 (See protein sequence)
Recommended Name: DNA-directed RNA polymerase I subunit RPA43  
Size: 338 amino acids; 37432 Da
Subunit: Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity).
Interacts with RRN3/TIF-IA
Sequence caution: Sequence=AAH14574.1; Type=Frameshift; Positions=224;
Secondary accessions: A0PJ45 B7Z724

Explore the universe of human proteins at neXtProt for TWISTNB: NX_Q3B726

Explore proteomics data for TWISTNB at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TWISTNB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001002926.1  
    ENSEMBL proteins: 
     ENSP00000222567  

    TWISTNB Human Recombinant Protein Products:

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    Novus Biologicals TWISTNB Lysate
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    Cloud-Clone Corp. Proteins for TWISTNB

     
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    antibodies-online proteins for TWISTNB (2 products) 

     
    antibodies-online peptides for TWISTNB

    TWISTNB Antibody Products:

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    antibodies-online antibodies for TWISTNB (13 products) 

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    Cloud-Clone Corp. ELISAs for TWISTNB
    Cloud-Clone Corp. CLIAs for TWISTNB
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    antibodies-online kits for TWISTNB (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005576 RNA_pol_Rpb7_N

    Graphical View of Domain Structure for InterPro Entry Q3B726

    ProtoNet protein and cluster: Q3B726

    UniProtKB/Swiss-Prot: RPA43_HUMAN, Q3B726
    Similarity: Belongs to the eukaryotic RPA43 RNA polymerase subunit family


    Find genes that share domains with TWISTNB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RPA43_HUMAN, Q3B726
    Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside
    triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through
    its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001054contributes to RNA polymerase I activity IBA--
    GO:0003899DNA-directed RNA polymerase activity ----
         
    Find genes that share ontologies with TWISTNB           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TWISTNB:
     Decreased TP53 protein express  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TWISTNB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TWISTNB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TWISTNB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TWISTNB

    miRNA
    Products:
        
    miRTarBase miRNAs that target TWISTNB:
    hsa-mir-92a-3p (MIRT049378), hsa-mir-96-5p (MIRT027899), hsa-mir-9-5p (MIRT021399), hsa-mir-3176 (MIRT052792)

    Block miRNA regulation of human, mouse, rat TWISTNB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TWISTNB (see all 15):
    hsa-miR-2052 hsa-miR-142-5p hsa-miR-548p hsa-miR-429 hsa-miR-196a* hsa-miR-340 hsa-miR-888* hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidTWISTNB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TWISTNB

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TWISTNB (NM_001002926)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TWISTNB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TWISTNB

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TWISTNB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWISTNB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RPA43_HUMAN, Q3B726: Nucleus, nucleolus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    nucleus4
    extracellular2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005736DNA-directed RNA polymerase I complex IBA--
    GO:0015630microtubule cytoskeleton IDA--

    Find genes that share ontologies with TWISTNB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TWISTNB About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    Pyrimidine metabolism0.38
    2RNA Polymerase III Transcription Initiation
    RNA polymerase0.45
    3Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with TWISTNB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4 Kegg Pathways  (Kegg details for TWISTNB):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways
    RNA polymerase

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TWISTNB
    Interactions:

        Search GeneGlobe Interaction Network for TWISTNB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TWISTNB (Q3B7263 ENSP000002225674) via UniProtKB, MINT, STRING, and/or I2D (see all 103)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF1DQ9H5J83, ENSP000003149714I2D: score=2 STRING: ENSP00000314971
    ARRB2P321213I2D: score=1 
    POLR1EENSP000003670294STRING: ENSP00000367029
    POLR2EENSP000002155874STRING: ENSP00000215587
    POLR2FENSP000004038524STRING: ENSP00000403852
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated ----
    GO:0006360transcription from RNA polymerase I promoter IBA--

    Find genes that share ontologies with TWISTNB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TWISTNB (RPA43)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TWISTNB gene: 
    NM_001002926.1  

    Unigene Cluster for TWISTNB:

    TWIST neighbor
    Hs.353035  [show with all ESTs]
    Unigene Representative Sequence: NM_001002926
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222567(uc003sup.1) ENST00000462263
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TWISTNB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TWISTNB (see all 15):
    hsa-miR-2052 hsa-miR-142-5p hsa-miR-548p hsa-miR-429 hsa-miR-196a* hsa-miR-340 hsa-miR-888* hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidTWISTNB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TWISTNB
    Predesigned siRNA for gene silencing in human, mouse, rat TWISTNB
    Clone
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    OriGene clones in human, mouse for TWISTNB (see all 7)
    OriGene ORF clones in mouse, rat for TWISTNB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TWISTNB (NM_001002926)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TWISTNB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TWISTNB
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TWISTNB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TWISTNB
      QuantiTect SYBR Green Assays in human, mouse, rat TWISTNB
      QuantiFast Probe-based Assays in human, mouse, rat TWISTNB

    Additional mRNA sequence: 

    AK090846.1 AK301329.1 BC013179.1 BC014574.1 BC056267.1 BC070358.1 BC130298.1 BC130300.1 

    4 DOTS entries:

    DT.101980128  DT.92422986  DT.100791610  DT.95224858 

    Selected AceView cDNA sequences (see all 132):

    BC013179 AA078823 NM_001002926 AA464720 BM454978 AA308959 AA463936 BP873431 
    BC056267 CF529920 BI861782 CB143061 BQ433945 AW969056 BX280121 AA400422 
    AI091623 AK090846 BU181180 BM796798 AA908753 BG178379 AA504560 CA311137 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TWISTNB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TWISTNB Expression
    About this image


    TWISTNB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    TWISTNB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TWISTNB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.353035

    UniProtKB/Swiss-Prot: RPA43_HUMAN, Q3B726
    Tissue specificity: Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in
    fetal lung, liver, and kidney, and low expression in all adult tissues

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TWISTNB gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Twistnb1 , 5 TWIST neighbor1, 5 80.56(n)1
    76.85(a)1
      12 (14.38 cM)5
    280711  NM_172253.21  NP_758457.11 
     334296245 
    chicken
    (Gallus gallus)
    Aves TWISTNB1 TWIST neighbor 65.03(n)
    56.54(a)
      420603  NM_001199615.1  NP_001186544.1 
    lizard
    (Anolis carolinensis)
    Reptilia TWISTNB6
    TWIST neighbor
    59(a)
    1 ↔ 1
    6(28881108-28886820)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.57762 Xenopus laevis transcribed sequence with weak similarity more 74.45(n)    BJ074347.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.185562 Danio rerio cDNA clone IMAGE6795293, partial cds 70.78(n)    BC056557.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG137736
    --
    28(a)
    1 ↔ 1
    2L(6906666-6907844)


    ENSEMBL Gene Tree for TWISTNB (if available)
    TreeFam Gene Tree for TWISTNB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TWISTNB gene

    Find genes that share paralogs with TWISTNB           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TWISTNB
    PGOHUM00000243284


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TWISTNB (see all 303)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1420238311,2
    C--19734647(+) ATTCC-/ATATGTC 1 -- ds50010--------
    rs1432126571,2
    --19734730(+) TGGAAC/GCAGAA 1 -- ds50010--------
    rs1810788251,2
    --19734771(+) GAATAC/GGGAGG 1 -- ds50010--------
    rs1461790201,2
    C--19734781(+) GGAGAC/TCAATG 1 -- ds50010--------
    rs1394431011,2
    --19734975(+) CACTAA/GAGTGA 1 -- ds50010--------
    rs1856569631,2
    --19735005(+) CATTAC/TATATA 1 -- ds50010--------
    rs2006838781,2
    C--19735014(+) AAAAA-/AGATGC 1 -- ds50010--------
    rs1905310511,2
    --19735165(+) GTTAAA/GTACTA 1 -- ut310--------
    rs1441360381,2
    --19735258(+) CAGGTA/GAACAG 1 -- ut310--------
    rs1180102581,2
    C,F--19735262(+) TAAACA/CGTTTG 1 -- ut311Minor allele frequency- C:0.02NA 120

    HapMap Linkage Disequilibrium report for TWISTNB (19735085 - 19748710 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TWISTNB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830918CNV Loss17160897
    nsv524807CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TWISTNB
    DNA2.0 Custom Variant and Variant Library Synthesis for TWISTNB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608312    OMIM disorders: --

    1 disease for TWISTNB:    
    About MalaCards
    acrocephalosyndactylia

    1 disease from the University of Copenhagen DISEASES database for TWISTNB:
    Acrocephalosyndactylia

    Find genes that share disorders with TWISTNB           About GenesLikeMe


    Export disorders for TWISTNB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TWISTNB gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with TWISTNB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region. (PubMed id 12438708)1, 2, 3 Kosan C. and Kunz J. (Cytogenet. Genome Res. 2002)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    4. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PubMed id 12393749)1, 2 Yuan X.... Grummt I. (EMBO Rep. 2002)
    5. Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins. (PubMed id 23537643)1 Liang C....Zhang L. (Biochem. Biophys. Res. Commun. 2013)
    6. Identification of the human testis protein phosphatase 1 interactome. (PubMed id 21382349)1 Fardilha M....da Cruz e Silva E.F. (Biochem. Pharmacol. 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    10. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221830 HGNC: 18027 AceView: TWISTNB Ensembl:ENSG00000105849 euGenes: HUgn221830
    ECgene: TWISTNB Kegg: 221830 H-InvDB: TWISTNB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TWISTNB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TWISTNB gene:
    Search GeneIP for patents involving TWISTNB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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