Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TWISTNB Gene

Aliases for TWISTNB Gene

  • TWIST Neighbor 2 3
  • Twist Neighbor Protein 4

External Ids for TWISTNB Gene

Previous GeneCards Identifiers for TWISTNB Gene

  • GC07M019380
  • GC07M019482
  • GC07M019508

Summaries for TWISTNB Gene

GeneCards Summary for TWISTNB Gene

TWISTNB (TWIST Neighbor) is a Protein Coding gene. Diseases associated with TWISTNB include acrocephalosyndactylia. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for TWISTNB Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TWISTNB Gene

Genomics for TWISTNB Gene

Regulatory Elements for TWISTNB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TWISTNB Gene

Start:
19,695,462 bp from pter
End:
19,709,087 bp from pter
Size:
13,626 bases
Orientation:
Minus strand

Genomic View for TWISTNB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TWISTNB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TWISTNB Gene

Proteins for TWISTNB Gene

  • Protein details for TWISTNB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3B726-RPA43_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA43
    Protein Accession:
    Q3B726
    Secondary Accessions:
    • A0PJ45
    • B7Z724

    Protein attributes for TWISTNB Gene

    Size:
    338 amino acids
    Molecular mass:
    37432 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with RRN3/TIF-IA.
    SequenceCaution:
    • Sequence=AAH14574.1; Type=Frameshift; Positions=224; Evidence={ECO:0000305};

neXtProt entry for TWISTNB Gene

Proteomics data for TWISTNB Gene at MOPED

Post-translational modifications for TWISTNB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TWISTNB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TWISTNB Gene

Domains for TWISTNB Gene

Protein Domains for TWISTNB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TWISTNB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3B726

UniProtKB/Swiss-Prot:

RPA43_HUMAN :
  • Q3B726
Family:
  • Belongs to the eukaryotic RPA43 RNA polymerase subunit family.
genes like me logo Genes that share domains with TWISTNB: view

No data available for Gene Families for TWISTNB Gene

Function for TWISTNB Gene

Molecular function for TWISTNB Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Through its association with RRN3/TIF-IA may be involved in recruitment of Pol I to rDNA promoters

Gene Ontology (GO) - Molecular Function for TWISTNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0003899 DNA-directed RNA polymerase activity --
genes like me logo Genes that share ontologies with TWISTNB: view

Phenotypes for TWISTNB Gene

genes like me logo Genes that share phenotypes with TWISTNB: view

Animal Model Products

CRISPR Products

miRNA for TWISTNB Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TWISTNB Gene

Localization for TWISTNB Gene

Subcellular locations from UniProtKB/Swiss-Prot for TWISTNB Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TWISTNB Gene COMPARTMENTS Subcellular localization image for TWISTNB gene
Compartment Confidence
cytoskeleton 4
nucleus 4
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for TWISTNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with TWISTNB: view

Pathways for TWISTNB Gene

genes like me logo Genes that share pathways with TWISTNB: view

Pathways by source for TWISTNB Gene

Gene Ontology (GO) - Biological Process for TWISTNB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated --
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
GO:0006363 termination of RNA polymerase I transcription TAS --
genes like me logo Genes that share ontologies with TWISTNB: view

Transcripts for TWISTNB Gene

mRNA/cDNA for TWISTNB Gene

Unigene Clusters for TWISTNB Gene

TWIST neighbor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TWISTNB

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TWISTNB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TWISTNB Gene

No ASD Table

Relevant External Links for TWISTNB Gene

GeneLoc Exon Structure for
TWISTNB
ECgene alternative splicing isoforms for
TWISTNB

Expression for TWISTNB Gene

mRNA expression in normal human tissues for TWISTNB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TWISTNB Gene

SOURCE GeneReport for Unigene cluster for TWISTNB Gene Hs.353035

mRNA Expression by UniProt/SwissProt for TWISTNB Gene

Q3B726-RPA43_HUMAN
Tissue specificity: Widely expressed. Expressed in all fetal and adult tissues tested, with highest expression in fetal lung, liver, and kidney, and low expression in all adult tissues.
genes like me logo Genes that share expressions with TWISTNB: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TWISTNB Gene

Orthologs for TWISTNB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TWISTNB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TWISTNB 35
  • 99.11 (n)
  • 99.7 (a)
TWISTNB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TWISTNB 35
  • 84.46 (n)
  • 80.67 (a)
TWISTNB 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TWISTNB 35
  • 85.39 (n)
  • 80.78 (a)
TWISTNB 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Twistnb 35
  • 80.56 (n)
  • 76.85 (a)
Twistnb 16
Twistnb 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TWISTNB 36
  • 41 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TWISTNB 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Twistnb 35
  • 81.28 (n)
  • 77.6 (a)
chicken
(Gallus gallus)
Aves TWISTNB 35
  • 65.03 (n)
  • 56.54 (a)
TWISTNB 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TWISTNB 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5776 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9460 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18556 35
twistnb 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13773 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA43 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for TWISTNB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TWISTNB Gene

ENSEMBL:
Gene Tree for TWISTNB (if available)
TreeFam:
Gene Tree for TWISTNB (if available)

Paralogs for TWISTNB Gene

Pseudogenes.org Pseudogenes for TWISTNB Gene

genes like me logo Genes that share paralogs with TWISTNB: view

No data available for Paralogs for TWISTNB Gene

Variants for TWISTNB Gene

Sequence variations from dbSNP and Humsavar for TWISTNB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1003899 -- 19,709,152(-) CTGGT(C/G)AGGGC upstream-variant-2KB
rs1029554 -- 19,708,001(-) TGGTT(C/T)AAAAG intron-variant
rs2072184 -- 19,709,260(-) ACATT(C/T)GCCTG upstream-variant-2KB
rs2072185 -- 19,709,077(-) GAGCG(C/T)CGGGG upstream-variant-2KB
rs2072186 -- 19,708,384(-) TTGAC(A/G)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TWISTNB Gene

Variant ID Type Subtype PubMed ID
nsv524807 CNV Gain 19592680
nsv830918 CNV Loss 17160897

Relevant External Links for TWISTNB Gene

HapMap Linkage Disequilibrium report
TWISTNB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TWISTNB Gene

Disorders for TWISTNB Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TWISTNB Gene including...

Search for TWISTNB Gene in MalaCards »

(1) University of Copenhagen DISEASES for TWISTNB Gene

genes like me logo Genes that share disorders with TWISTNB: view

No data available for UniProtKB/Swiss-Prot for TWISTNB Gene

Publications for TWISTNB Gene

  1. Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region. (PMID: 12438708) Kosan C. … Kunz J. (Cytogenet. Genome Res. 2002) 2 3 4
  2. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PMID: 12393749) Yuan X. … Grummt I. (EMBO Rep. 2002) 3 4
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PMID: 17620599) Xiao K. … Lefkowitz R.J. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3

Products for TWISTNB Gene

Sources for TWISTNB Gene

Back to Top

Content