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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TWF2 Gene

protein-coding   GIFtS: 58
GCID: GC03M052262

Twinfilin Actin-Binding Protein 2

(Previous names: protein tyrosine kinase 9-like (A6-related protein), PTK9L...)
(Previous symbol: PTK9L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Twinfilin Actin-Binding Protein 21 2     Twinfilin, Actin-Binding Protein, Homolog 2 (Drosophila)1
PTK9L1 2 3 5     A6r2
Protein Tyrosine Kinase 9-Like (A6-Related Protein)1 2     Twinfilin, Actin-Binding Protein, Homolog 22
PTK9L Protein Tyrosine Kinase 9-Like (A6-Related Protein)1 2     twinfilin-22
Twinfilin-1-Like Protein2 3     hA6RP3
A6-Related Protein2 3     Protein Tyrosine Kinase 9-Like3
A6RP2 5     

External Ids:    HGNC: 96211   Entrez Gene: 113442   Ensembl: ENSG000002475967   OMIM: 6074335   UniProtKB: Q6IBS03   

Export aliases for TWF2 gene to outside databases

Previous GC identifer: GC03M052233


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TWF2 Gene:
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase
C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to
twinfilin (PTK9), a conserved actin monomer-binding protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for TWF2 Gene: 
TWF2 (twinfilin actin-binding protein 2) is a protein-coding gene. Diseases associated with TWF2 include monkeypox, and smallpox. GO annotations related to this gene include protein kinase C binding and actin monomer binding. An important paralog of this gene is TWF1.

UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0
Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization,
likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to
play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role
in regulating the mature length of the middle and short rows of stereocilia (By similarity)

Gene Wiki entry for TWF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TWF2 gene promoter:
         STAT1   AP-1   ATF-2   CREB   MEF-2A   deltaCREB   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTWF2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TWF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TWF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

TWF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TWF2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052262:  view genomic region     (about GC identifiers)

Start:
52,262,626 bp from pter      End:
52,273,276 bp from pter
Size:
10,651 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0 (See protein sequence)
Recommended Name: Twinfilin-2  
Size: 349 amino acids; 39548 Da
Subunit: Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1
and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A (By
similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, stereocilium (By
similarity). Note=Perinuclear and G-actin-rich cortical actin structure sublocalization
2 PDB 3D structures from and Proteopedia for TWF2:
2VAC (3D)        2W0I (3D)    
Secondary accessions: Q9Y3F5

Explore the universe of human proteins at neXtProt for TWF2: NX_Q6IBS0

Explore proteomics data for TWF2 at MOPED 

Post-translational modifications:

  • UniProtKB: In vitro, phosphorylated by PRKCZ, CK2 and SRC
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IBS0

  • TWF2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TWF2 Protein Expression
    REFSEQ proteins: NP_009215.1  
    ENSEMBL proteins: 
     ENSP00000303908   ENSP00000426464  

    Human Recombinant Protein Products for TWF2: 
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    Cloud-Clone Corp. Proteins for TWF2 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm NAS10406962
    GO:0005856cytoskeleton IEA--
    GO:0030016myofibril ISS18837697
    GO:0030027lamellipodium ISS12807912

    TWF2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: twinfilin, actin-binding protein, homolog 2 (Drosophila) 
    Twinfilin subfamily

    1 InterPro protein domain:
     IPR002108 Actin-bd_cofilin/tropomyosin

    Graphical View of Domain Structure for InterPro Entry Q6IBS0

    ProtoNet protein and cluster: Q6IBS0

    1 Blocks protein domain: IPB002108 Actin-binding

    UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0
    Similarity: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily
    Similarity: Contains 2 ADF-H domains


    TWF2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TWF2_HUMAN, Q6IBS0
    Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization,
    likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to
    play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role
    in regulating the mature length of the middle and short rows of stereocilia (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0003785actin monomer binding ISS12807912
    GO:0005080protein kinase C binding IPI10406962
    GO:0005524ATP binding IDA10406962
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS12807912
         
    TWF2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TWF2:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Twf2):
     normal 

    TWF2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TWF2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TWF2 
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    miRTarBase miRNAs that target TWF2:
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TWF2:
    hsa-miR-3173-3p hsa-miR-4310 hsa-miR-4272 hsa-miR-3120-3p hsa-miR-1179 hsa-miR-548c-3p hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidTWF2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWF2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TWF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/24 Interacting proteins for TWF2 (Q6IBS02, 3 ENSP000003039084) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3MINT-65851 I2D: score=5 
    ARHGDIAP525652, 3, ENSP000002693214MINT-8276042 I2D: score=2 STRING: ENSP00000269321
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=2 STRING: ENSP00000256001
    CAPZA1P529073, ENSP000002631684I2D: score=2 STRING: ENSP00000263168
    CAPZA2P477553, ENSP000003549474I2D: score=2 STRING: ENSP00000354947
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010592positive regulation of lamellipodium assembly IMP17910947
    GO:0010976positive regulation of neuron projection development IMP17910947
    GO:0030030cell projection organization IEA--
    GO:0030837negative regulation of actin filament polymerization ISS12807912
    GO:0032532regulation of microvillus length IC19955359

    TWF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TWF2

    Search CenterWatch for drugs/clinical trials and news about TWF2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TWF2 gene: 
    NM_007284.3  

    Unigene Cluster for TWF2:

    Twinfilin, actin-binding protein, homolog 2 (Drosophila)
    Hs.436439  [show with all ESTs]
    Unigene Representative Sequence: NM_007284
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305533(uc003ddd.3) ENST00000499914 ENST00000472755
    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate TWF2:
    hsa-miR-3173-3p hsa-miR-4310 hsa-miR-4272 hsa-miR-3120-3p hsa-miR-1179 hsa-miR-548c-3p hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidTWF2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TWF2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TWF2

    Additional mRNA sequence: 

    AF109365.1 AL136773.1 BC000327.2 BC003161.1 BC016452.1 CR456732.1 CR533520.1 Y17169.1 

    17 DOTS entries:

    DT.87016935  DT.100051457  DT.95250806  DT.100851324  DT.100671000  DT.100852878  DT.120897640  DT.100670988 
    DT.100670990  DT.100671002  DT.100850956  DT.100870045  DT.87016934  DT.95371467  DT.100052497  DT.451349 
    DT.91647419 

    24/543 AceView cDNA sequences (see all 543):

    BE272038 CR611569 BQ879863 CR533520 AI090271 BQ049826 CA425086 BI963999 
    BG115588 NM_007284 NM_138688 BQ678080 BQ184602 CD368665 CA446634 CR602270 
    AA832218 BM763490 BQ072949 AI494258 BU194725 BM456154 CR607625 BF725768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TWF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTGGCCT
    TWF2 Expression
    About this image


    See TWF2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TWF2

    SOURCE GeneReport for Unigene cluster: Hs.436439

    UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0
    Tissue specificity: Ubiquitously expressed (at protein level)

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TWF2 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Twf21 , 5 twinfilin, actin-binding protein, homolog 2 (Drosophila)1, 5 87.97(n)1
    96.56(a)1
      9 (57.46 cM)5
    239991  NM_011876.31  NP_036006.11 
     1062031085 
    chicken
    (Gallus gallus)
    Aves TWF21 twinfilin, actin-binding protein, homolog 2 (Drosophila) 79.37(n)
    83.95(a)
      415940  NM_001030589.1  NP_001025760.1 
    lizard
    (Anolis carolinensis)
    Reptilia TWF26
    Uncharacterized protein
    82(a)
    1 ↔ 1
    2(153395087-153478261)
    African clawed frog
    (Xenopus laevis)
    Amphibia ptk9l-prov2 PTK9 protein typrotein tyrosine kinase 9-like (A6-related more 75.53(n)    BC044672.1 
    zebrafish
    (Danio rerio)
    Actinopterygii twf21 twinfilin-like protein 69.41(n)
    73.53(a)
      100310784  NM_001009897.1  NP_001009897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twf6
    twinfilin
    50(a)
    1 → many
    3R(9948380-9950196)
    worm
    (Caenorhabditis elegans)
    Secernentea F38E9.56
    Protein F38E9.5
    34(a)
    1 → many
    X(16446197-16451336)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TWF1(YGR080W)4 Twinfilin, highly conserved actin monomer-sequestering more   --   7(642010-643008) 852971  NP_011594.1 


    ENSEMBL Gene Tree for TWF2 (if available)
    TreeFam Gene Tree for TWF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TWF2 gene
    TWF12  
    1 SIMAP similar gene for TWF2 using alignment to 2 protein entries:     TWF2_HUMAN (see all proteins):
    TWF1

    TWF2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/301 SNPs in TWF2 are shown (see all 301)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0424094
    A lung neuroendocrine carcinoma sample4--see VAR_0424092 A T mis40--------
    rs57438341,2
    C,F--52262323(-) ttcgaA/Ggaaac 1 -- ds50017Minor allele frequency- G:0.02NA EU WA 334
    rs752198091,2
    C,F--52262382(+) TATGCA/GGATCC 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs754223561,2
    C,F--52262422(+) CTCCAG/ACAGGG 1 -- ds50011Minor allele frequency- A:0.07EA 120
    rs37330661,2
    C,F,H--52262450(+) ACCCGC/TGTGAG 1 -- ds500110Minor allele frequency- T:0.01EA NS NA 2602
    rs115502541,2
    F--52263017(+) CCCCAC/G/TAGTCC 2 -- ut310--------
    rs1886434961,2
    C--52263033(+) TGGCCA/GGCCCT 1 -- ut310--------
    rs1420166831,2
    F--52263080(+) GGGCCG/ACGGAT 2 /R syn11Minor allele frequency- A:0.00NA 4544
    rs1440754571,2
    C--52263131(+) TTGGCG/AAAGGC 2 /F syn11Minor allele frequency- A:0.00NA 4552
    rs1996097961,2
    C--52263148(+) GAAGGC/TGTGTT 2 T A mis10--------

    HapMap Linkage Disequilibrium report for TWF2 (52262626 - 52273276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for TWF2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508926CNV Insertion20534489
    nsv834695CNV Loss17160897
    nsv460537CNV Loss19166990
    nsv876789CNV Loss21882294
    nsv876790CNV Loss21882294
    nsv508218CNV Loss20534489
    nsv470572CNV Loss18288195
    nsv876791CNV Loss21882294
    nsv834694CNV Gain17160897
    dgv5136n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607433    OMIM disorders: --

    7 diseases for TWF2:    About MalaCards
    monkeypox    smallpox    cowpox    vaccinia
    meningioma    neuronitis    leukemia

    2 diseases from the University of Copenhagen DISEASES database for TWF2:
    Monkeypox     Cowpox

    TWF2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TWF2
    Human Genome Epidemiology (HuGE) Navigator: TWF2 (7 documents)

    Export disorders for TWF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TWF2 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with TWF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and characterization of an A6 related protein. (PubMed id 10406962)1, 2, 3, 9 Rohwer A.... Gschwendt M. (1999)
    2. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    3. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. (PubMed id 12807912)1, 3 Vartiainen M.K....Lappalainen P. (2003)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11344 HGNC: 9621 AceView: PTK9LandTLR9 Ensembl:ENSG00000247596 euGenes: HUgn11344
    ECgene: TWF2 H-InvDB: TWF2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TWF2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt073.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TWF2 gene:
    Search GeneIP for patents involving TWF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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