TWF2 Gene
protein-coding GIFtS: 56
GCID: GC03M052262
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twinfilin, actin-binding protein, homolog 2 (Drosophila)(Previous names: protein tyrosine kinase 9-like (A6-related protein), PTK9L...) (Previous symbol: PTK9L)
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Aliases for TWF2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Twinfilin, Actin-Binding Protein, Homolog 2 (Drosophila)1 2 | | Twinfilin-1-Like Protein2 3 | | PTK9L1 2 3 5 | | A6-Related Protein2 3 | | A6RP1 2 5 | | Twinfilin-21 | | A6r1 2 | | HA6RP1 | | Protein Tyrosine Kinase 9-Like (A6-Related Protein)1 2 | | Protein Tyrosine Kinase 9-Like3 | | PTK9L Protein Tyrosine Kinase 9-Like (A6-Related Protein)1 2 | | |
Export aliases for TWF2 gene to outside databasesPrevious GC identifer: GC03M052233 |
Summaries for TWF2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TWF2: The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta.The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin(PTK9), a conserved actin monomer-binding protein. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likelyby sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play animportant role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role inregulating the mature length of the middle and short rows of stereocilia (By similarity) Gene Wiki entry for TWF2
|
Genomic Views for TWF2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TWF2 gene promoter: STAT1 AP-1 ATF-2 CREB MEF-2A deltaCREB c-Jun RSRFC4 Other transcription factors
Search SABiosciences Chromatin IP Primers for TWF2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TWF2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.2 HGNC cytogenetic band: 3p21.1TWF2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M052262: view genomic region
(about GC identifiers)
Start:
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52,262,626 bp from pter |
End:
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52,273,183 bp from pter |
Size:
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10,558 bases |
Orientation:
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minus strand |
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Proteins for TWF2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0 (See
protein sequence)Recommended Name: Twinfilin-2 Size: 349 amino acids; 39548 Da
Subunit: Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1 andphosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A (By similarity)
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, stereocilium (Bysimilarity). Note=Perinuclear and G-actin-rich cortical actin structure sublocalization
2 PDB 3D structures from and Proteopedia for TWF2:2VAC (3D)
  2W0I (3D)
 
Secondary accessions: Q9Y3F5Explore the universe of human proteins at neXtProt for TWF2: NX_Q6IBS0
Post-translational modifications:
In vitro, phosphorylated by PRKCZ, CK2 and SRC1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6IBS0 TWF2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009215.1 ENSEMBL proteins: ENSP00000303908 ENSP00000426464 Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
TWF2 for ontologies About GeneDecksing
TWF2 Antibody Products: Assay Products for TWF2: |
Protein
Domains / Families for TWF2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TWF2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6IBS0ProtoNet protein and cluster: Q6IBS0 1 Blocks protein family: IPB002108 Actin-binding
UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0Similarity: Belongs to the actin-binding proteins ADF family. Twinfilin subfamilySimilarity: Contains 2 ADF-H domains |
Function for TWF2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likelyby sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play animportant role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role inregulating the mature length of the middle and short rows of stereocilia (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TWF2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TWF2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TWF2 (NM_007284) | |  | Sino Biological Human cDNA Clone for TWF2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TWF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TWF2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWF2 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
TWF2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TWF2: Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Twf2):
TWF2 for phenotypes About GeneDecksing
|
Pathways & Interactions for TWF2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TWF2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
 5/24 Interacting proteins for TWF2 (Q6IBS02, 3 ENSP000003039084) via UniProtKB, MINT, STRING, and/or I2D (see all 24)About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
TWF2 for ontologies About GeneDecksing
|
Drugs & Compounds for TWF2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TWF2 Search CenterWatch for drugs/clinical trials and news about TWF2 
|
Transcripts for TWF2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TWF2 gene: NM_007284.3 Unigene Cluster for TWF2: Twinfilin, actin-binding protein, homolog 2 (Drosophila) Hs.436439 [show with all ESTs]Unigene Representative Sequence: NM_0072843 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000305533(uc003ddd.3) ENST00000499914 ENST00000472755
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TWF2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TWF2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TWF2 (NM_007284) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TWF2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TWF2  |
Additional cDNA sequence: AF109365.1 AL136773.1 BC000327.2 BC003161.1 BC016452.1 CR456732.1 CR533520.1 Y17169.1 17 DOTS entries: DT.87016935 DT.100051457 DT.95250806 DT.100851324 DT.100671000 DT.100852878 DT.120897640 DT.100670988 DT.100670990 DT.100671002 DT.100850956 DT.100870045 DT.87016934 DT.95371467 DT.100052497 DT.451349 DT.91647419 24/543 AceView cDNA sequences (see all 543): BM542486 AI088343 AF259262 BQ678137 CR611569 CD367730 BM548133 AI598285 BQ072949 AF259263 AW248880 CR596947 AI090271 BM470262 AA580444 CF127433 BQ879863 BM781893 CR623453 AF246974 F04324 CA427933 CD624013 CR607625 GeneLoc Exon Structure
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Expression for TWF2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TWF2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AACCTGGCCT
About this image See TWF2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TWF2
SOURCE GeneReport for Unigene cluster: Hs.436439 UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0Tissue specificity: Ubiquitously expressed (at protein level) SABiosciences Custom PCR Arrays for TWF2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TWF2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TWF2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TWF2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TWF2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWF2 |
Orthologs for TWF2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TWF2 gene from 6/25 species (see all 25) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
TWF21 |
twinfilin, actin-binding protein, homolog 2 (Drosophila) |
79.37(n) 83.95(a) |
  |
415940 NM_001030589.1 NP_001025760.1 |
lizard (Anolis carolinensis) |
Reptilia |
TWF26 |
-- |
84(a) |
1 ↔ 1 |
2(153446070-153478261) |
African clawed frog (Xenopus laevis) |
Amphibia |
ptk9l-prov2 |
PTK9 protein typrotein tyrosine kinase 9-like (A6-related more |
75.53(n) |
  |
BC044672.1 |
zebrafish (Danio rerio) |
Actinopterygii |
twf21 |
twinfilin-like protein |
69.41(n) 73.53(a) |
  |
100310784 NM_001009897.1 NP_001009897.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
twf6 |
twinfilin |
49(a) |
1 → many |
3R(9948380-9950196) |
worm (Caenorhabditis elegans) |
Secernentea |
F38E9.56 |
Protein F38E9.5 |
34(a) |
1 → many |
X(16446125-16451264) |
ENSEMBL Gene Tree for TWF2 (if available) TreeFam Gene Tree for TWF2 (if available)  |
Paralogs for TWF2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TWF2 gene
- TWF12
1 SIMAP similar gene for TWF2 using alignment to 2 protein entries: TWF2_HUMAN (see all proteins):TWF1
TWF2 for paralogs About GeneDecksing
|
Genomic Variants for TWF2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TWF2 (52262626 - 52273183 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for TWF2 2 CNVs: 51113 4337  | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases for TWF2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TWF2 for disorders About GeneDecksing
OMIM gene information: 607433
OMIM disorders: --
7 diseases for TWF2: About MalaCardsmonkeypox cowpox smallpox vaccinia meningioma leukemia neuronitis 2 diseases from the University of Copenhagen DISEASES database for TWF2:Monkeypox Cowpox Human Genome Epidemiology (HuGE) Navigator: TWF2 (7 documents) Export disorders for TWF2 gene to outside databases
|
Publications for TWF2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TWF2 gene, integrated from 9 sources (see all 29): (articles sorted by number of sources associating them with TWF2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning, expression and characterization of an A6 related protein. (PubMed id 10406962)1, 2, 3, 9 Rohwer A.... Gschwendt M. (1999)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. (PubMed id 12807912)1, 3 Vartiainen M.K....Lappalainen P. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1 Sklar P....Purcell S.M. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for TWF2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TWF2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TWF2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TWF2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TWF2 | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt073.shtml |
|
| | |
About This Section
| Patent Information for TWF2 gene: Search GeneIP for patents involving TWF2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TWF2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TWF2 | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TWF2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TWF2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TWF2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TWF2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TWF2 |
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| | | Search Tocris compounds for TWF2 |
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 | | TWF2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWF2 |
|  |  |  | | | ThermoFisher Antibodies for TWF2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TWF2 |
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