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TWF2 Gene

protein-coding   GIFtS: 58
GCID: GC03M052262

Twinfilin Actin-Binding Protein 2

(Previous names: protein tyrosine kinase 9-like (A6-related protein), PTK9L...)
(Previous symbol: PTK9L)
  See TWF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Twinfilin Actin-Binding Protein 21 2     Twinfilin, Actin-Binding Protein, Homolog 2 (Drosophila)1
PTK9L1 2 3 5     A6r2
Protein Tyrosine Kinase 9-Like (A6-Related Protein)1 2     Twinfilin, Actin-Binding Protein, Homolog 22
PTK9L Protein Tyrosine Kinase 9-Like (A6-Related Protein)1 2     twinfilin-22
Twinfilin-1-Like Protein2 3     hA6RP3
A6-Related Protein2 3     Protein Tyrosine Kinase 9-Like3
A6RP2 5     

External Ids:    HGNC: 96211   Entrez Gene: 113442   Ensembl: ENSG000002475967   OMIM: 6074335   UniProtKB: Q6IBS03   

Export aliases for TWF2 gene to outside databases

Previous GC identifer: GC03M052233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TWF2 Gene:
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase
C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to
twinfilin (PTK9), a conserved actin monomer-binding protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for TWF2 Gene:
TWF2 (twinfilin actin-binding protein 2) is a protein-coding gene. Diseases associated with TWF2 include monkeypox. GO annotations related to this gene include protein kinase C binding and actin monomer binding. An important paralog of this gene is TWF1.

UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0
Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization,
likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to
play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role
in regulating the mature length of the middle and short rows of stereocilia (By similarity)

Gene Wiki entry for TWF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TWF2 gene promoter:
         STAT1   AP-1   ATF-2   CREB   MEF-2A   deltaCREB   c-Jun   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTWF2 promoter sequence
   Search Chromatin IP Primers for TWF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TWF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.2   HGNC cytogenetic band: 3p21.1

TWF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TWF2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M052262:  view genomic region     (about GC identifiers)

Start:
52,262,626 bp from pter      End:
52,273,276 bp from pter
Size:
10,651 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0 (See protein sequence)
Recommended Name: Twinfilin-2  
Size: 349 amino acids; 39548 Da
Subunit: Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF1
and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated. Interacts with MYO7A (By
similarity)
2 PDB 3D structures from and Proteopedia for TWF2:
2VAC (3D)        2W0I (3D)    
Secondary accessions: Q9Y3F5

Explore the universe of human proteins at neXtProt for TWF2: NX_Q6IBS0

Explore proteomics data for TWF2 at MOPED

Post-translational modifications: 

  • In vitro, phosphorylated by PRKCZ, CK2 and SRC1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TWF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009215.1  
    ENSEMBL proteins: 
     ENSP00000303908   ENSP00000426464  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: twinfilin, actin-binding protein, homolog 2 (Drosophila)
    Twinfilin subfamily

    2 InterPro protein domains:
     IPR002108 Actin-bd_cofilin/tropomyosin
     IPR028458 Twinfilin

    Graphical View of Domain Structure for InterPro Entry Q6IBS0

    ProtoNet protein and cluster: Q6IBS0

    1 Blocks protein domain: IPB002108 Actin-binding

    UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0
    Similarity: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily
    Similarity: Contains 2 ADF-H domains


    Find genes that share domains with TWF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TWF2_HUMAN, Q6IBS0
    Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization,
    likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to
    play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role
    in regulating the mature length of the middle and short rows of stereocilia (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0003785actin monomer binding ISS12807912
    GO:0005080protein kinase C binding IPI10406962
    GO:0005524ATP binding IDA10406962
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS12807912
         
    Find genes that share ontologies with TWF2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TWF2:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Twf2):
     normal 

    Find genes that share phenotypes with TWF2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TWF2

    miRNA
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    miRTarBase miRNAs that target TWF2:
    hsa-mir-126-3p (MIRT005540), hsa-mir-484 (MIRT042297), hsa-mir-1 (MIRT005539)

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    7 qRT-PCR Assays for microRNAs that regulate TWF2:
    hsa-miR-3173-3p hsa-miR-4310 hsa-miR-4272 hsa-miR-3120-3p hsa-miR-1179 hsa-miR-548c-3p hsa-miR-455-3p
    SwitchGear 3'UTR luciferase reporter plasmidTWF2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TWF2_HUMAN, Q6IBS0: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, stereocilium (By
    similarity). Note=Perinuclear and G-actin-rich cortical actin structure sublocalization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm NAS10406962
    GO:0005856cytoskeleton IEA--
    GO:0030016myofibril ISS18837697
    GO:0030027lamellipodium ISS12807912

    Find genes that share ontologies with TWF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TWF2 About    
    See pathways by source

    SuperPathContained pathways About
    1Insulin receptor signalling cascade
    Insulin receptor signalling cascade0.94
    IGF1R signaling cascade0.92
    IRS-related events0.94
    IRS-related events triggered by IGF1R0.92
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)0.92
    PI3K Cascade0.87
    IRS-mediated signalling0.92
    Signaling by Insulin receptor0.80
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88 dependent cascade initiated on endosome0.69
    Toll Like Receptor 9 (TLR9) Cascade0.93
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    3Signaling by GPCR
    Signal Transduction0.58
    4Trafficking and processing of endosomal TLR
    Trafficking and processing of endosomal TLR




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TWF2
    Interactions:

        Search GeneGlobe Interaction Network for TWF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TWF2 (Q6IBS02, 3 ENSP000003039084) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHGBP050602, 3MINT-65851 I2D: score=5 
    ARHGDIAP525652, 3, ENSP000002693214MINT-8276042 I2D: score=2 STRING: ENSP00000269321
    ACTR3BQ9P1U13, ENSP000002560014I2D: score=2 STRING: ENSP00000256001
    CAPZA1P529073, ENSP000002631684I2D: score=2 STRING: ENSP00000263168
    CAPZA2P477553, ENSP000003549474I2D: score=2 STRING: ENSP00000354947
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010592positive regulation of lamellipodium assembly IMP17910947
    GO:0010976positive regulation of neuron projection development IMP17910947
    GO:0030030cell projection organization IEA--
    GO:0030837negative regulation of actin filament polymerization ISS12807912
    GO:0032532regulation of microvillus length IC19955359

    Find genes that share ontologies with TWF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TWF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TWF2 gene: 
    NM_007284.3  

    Unigene Cluster for TWF2:

    Twinfilin, actin-binding protein, homolog 2 (Drosophila)
    Hs.436439  [show with all ESTs]
    Unigene Representative Sequence: NM_007284
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305533(uc003ddd.3) ENST00000499914 ENST00000472755
    miRNA
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    hsa-miR-3173-3p hsa-miR-4310 hsa-miR-4272 hsa-miR-3120-3p hsa-miR-1179 hsa-miR-548c-3p hsa-miR-455-3p
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    Additional mRNA sequence: 

    AF109365.1 AL136773.1 BC000327.2 BC003161.1 BC016452.1 CR456732.1 CR533520.1 Y17169.1 

    17 DOTS entries:

    DT.87016935  DT.100051457  DT.95250806  DT.100851324  DT.100671000  DT.100852878  DT.120897640  DT.100670988 
    DT.100670990  DT.100671002  DT.100850956  DT.100870045  DT.87016934  DT.95371467  DT.100052497  DT.451349 
    DT.91647419 

    Selected AceView cDNA sequences (see all 543):

    CR600187 CD368665 CR603095 AB045180 BM907591 AA832218 AW246538 CR590947 
    BG575994 AW248880 AI299293 CR607625 AA872900 CB270332 CR599346 CR533520 
    BM544780 BQ678621 CR611569 BC000327 CR593060 BM927986 BU629872 AF245704 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TWF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCTGGCCT
    TWF2 Expression
    About this image

    TWF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TWF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436439

    UniProtKB/Swiss-Prot: TWF2_HUMAN, Q6IBS0
    Tissue specificity: Ubiquitously expressed (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TWF2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Twf21 , 5 twinfilin, actin-binding protein, homolog 2 (Drosophila)1, 5 87.97(n)1
    96.56(a)1
      9 (57.46 cM)5
    239991  NM_011876.31  NP_036006.11 
     1062031085 
    chicken
    (Gallus gallus)
    Aves TWF21 twinfilin, actin-binding protein, homolog 2 (Drosophila) 79.37(n)
    83.95(a)
      415940  NM_001030589.1  NP_001025760.1 
    lizard
    (Anolis carolinensis)
    Reptilia TWF26
    twinfilin actin-binding protein 2
    82(a)
    1 ↔ 1
    2(153395087-153478261)
    African clawed frog
    (Xenopus laevis)
    Amphibia ptk9l-prov2 PTK9 protein typrotein tyrosine kinase 9-like (A6-related more 75.53(n)    BC044672.1 
    zebrafish
    (Danio rerio)
    Actinopterygii twf21 twinfilin-like protein 69.31(n)
    73.31(a)
      100310784  NM_001009897.1  NP_001009897.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twf6
    twinfilin
    50(a)
    1 → many
    3R(9948380-9950196)
    worm
    (Caenorhabditis elegans)
    Secernentea F38E9.56
    Protein F38E9.5 (F38E9.5) mRNA, complete cds
    34(a)
    1 → many
    X(16446197-16451336) WBGene00018187
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TWF1(YGR080W)4 Twinfilin, highly conserved actin monomer-sequestering more   --   7(642010-643008) 852971  NP_011594.1 


    ENSEMBL Gene Tree for TWF2 (if available)
    TreeFam Gene Tree for TWF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TWF2 gene
    TWF12  
    1 SIMAP similar gene for TWF2 using alignment to 2 protein entries:     TWF2_HUMAN (see all proteins):
    TWF1

    Find genes that share paralogs with TWF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TWF2 (see all 301)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0424094
    A lung neuroendocrine carcinoma sample4--see VAR_0424092 A T mis40--------
    rs57438341,2
    C,F--52262323(-) ttcgaA/Ggaaac 1 -- ds50017Minor allele frequency- G:0.02NA EU WA 334
    rs752198091,2
    C,F--52262382(+) TATGCA/GGATCC 1 -- ds50011Minor allele frequency- G:0.05WA 118
    rs754223561,2
    C,F--52262422(+) CTCCAG/ACAGGG 1 -- ds50011Minor allele frequency- A:0.07EA 120
    rs37330661,2
    C,F,H--52262450(+) ACCCGC/TGTGAG 1 -- ds500110Minor allele frequency- T:0.01EA NS NA 2602
    rs115502541,2
    F--52263017(+) CCCCAC/G/TAGTCC 2 -- ut310--------
    rs1886434961,2
    C--52263033(+) TGGCCA/GGCCCT 1 -- ut310--------
    rs1420166831,2
    F--52263080(+) GGGCCG/ACGGAT 2 /R syn11Minor allele frequency- A:0.00NA 4544
    rs1440754571,2
    C--52263131(+) TTGGCG/AAAGGC 2 /F syn11Minor allele frequency- A:0.00NA 4552
    rs1996097961,2
    C--52263148(+) GAAGGC/TGTGTT 2 T A mis10--------

    HapMap Linkage Disequilibrium report for TWF2 (52262626 - 52273276 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TWF2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508926CNV Insertion20534489
    nsv834695CNV Loss17160897
    nsv460537CNV Loss19166990
    nsv876789CNV Loss21882294
    nsv876790CNV Loss21882294
    nsv508218CNV Loss20534489
    nsv470572CNV Loss18288195
    nsv876791CNV Loss21882294
    nsv834694CNV Gain17160897
    dgv5136n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 607433    OMIM disorders: --

    1 disease for TWF2:    
    About MalaCards
    monkeypox

    2 diseases from the University of Copenhagen DISEASES database for TWF2:
    Monkeypox     Cowpox

    Find genes that share disorders with TWF2           About GenesLikeMe

    Genetic Association Database (GAD): TWF2
    Human Genome Epidemiology (HuGE) Navigator: TWF2 (7 documents)

    Export disorders for TWF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TWF2 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with TWF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and characterization of an A6 related protein. (PubMed id 10406962)1, 2, 3, 9 Rohwer A.... Gschwendt M. (Eur. J. Biochem. 1999)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated. (PubMed id 12807912)1, 3 Vartiainen M.K....Lappalainen P. (J. Biol. Chem. 2003)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 11344 HGNC: 9621 AceView: PTK9LandTLR9 Ensembl:ENSG00000247596 euGenes: HUgn11344
    ECgene: TWF2 H-InvDB: TWF2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TWF2 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/073

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TWF2 gene:
    Search GeneIP for patents involving TWF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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