Aliases for TWF2 Gene
External Ids for TWF2 Gene
Previous HGNC Symbols for TWF2 Gene
Previous GeneCards Identifiers for TWF2 Gene
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for TWF2 Gene
TWF2 (Twinfilin Actin-Binding Protein 2) is a Protein Coding gene. Diseases associated with TWF2 include monkeypox. Among its related pathways are Signaling by GPCR and Insulin receptor signalling cascade. GO annotations related to this gene include protein kinase C binding and actin monomer binding. An important paralog of this gene is TWF1.
UniProtKB/Swiss-Prot for TWF2 Gene
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).