Aliases for TWF1 Gene
External Ids for TWF1 Gene
Previous Symbols for TWF1 Gene
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]
GeneCards Summary for TWF1 Gene
TWF1 (Twinfilin Actin-Binding Protein 1) is a Protein Coding gene. Diseases associated with TWF1 include sleeping sickness. Among its related pathways are Cytoskeletal Signaling and Sweet Taste Signaling. GO annotations related to this gene include protein tyrosine kinase activity and actin monomer binding. An important paralog of this gene is TWF2.
UniProtKB/Swiss-Prot for TWF1 Gene
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).