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TWF1 Gene

protein-coding   GIFtS: 60
GCID: GC12M044187

Twinfilin Actin-Binding Protein 1

(Previous names: protein tyrosine kinase 9, PTK9 protein tyrosine kinase...)
(Previous symbol: PTK9)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Twinfilin Actin-Binding Protein 11 2     Twinfilin, Actin-Binding Protein, Homolog 1 (Drosophila)1
PTK91 2 3 5     A62
Protein Tyrosine Kinase 91 2 3     A6 Protein Tyrosine Kinase2
PTK9 Protein Tyrosine Kinase 91 2     Twinfilin, Actin-Binding Protein, Homolog 12
Protein A62 3     twinfilin-12

External Ids:    HGNC: 96201   Entrez Gene: 57562   Ensembl: ENSG000001512397   OMIM: 6109325   UniProtKB: Q127923   

Export aliases for TWF1 gene to outside databases

Previous GC identifers: GC12M042474 GC12M041215


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TWF1 Gene:
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the
mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to
cortical G-actin-rich structures may be regulated by the small GTPase RAC1. (provided by RefSeq, Jul 2008)

GeneCards Summary for TWF1 Gene:
TWF1 (twinfilin actin-binding protein 1) is a protein-coding gene. Diseases associated with TWF1 include sleeping sickness, and childhood leukemia. GO annotations related to this gene include actin monomer binding and protein tyrosine kinase activity. An important paralog of this gene is TWF2.

UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792
Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization,
likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to
play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)

Gene Wiki entry for TWF1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TWF1 gene promoter:
         GR   STAT5B   ER-alpha   AML1a   Nkx2-2   STAT5A   POU6F1 (c2)   C/EBPalpha   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTWF1 promoter sequence
   Search Chromatin IP Primers for TWF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TWF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

TWF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TWF1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M044187:  view genomic region     (about GC identifiers)

Start:
44,187,526 bp from pter      End:
44,200,178 bp from pter
Size:
12,653 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792 (See protein sequence)
Recommended Name: Twinfilin-1  
Size: 350 amino acids; 40283 Da
Subunit: Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2
and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated (By similarity)
Caution: Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity
Sequence caution: Sequence=AAH43148.2; Type=Erroneous initiation; Sequence=AAH68548.1; Type=Erroneous initiation;
Sequence=BAD92539.1; Type=Erroneous initiation;
Secondary accessions: A8K5A8 B3KXS6 B4DLX9 Q59G07 Q5U0B1 Q6FHJ1 Q6FHL6 Q6NUK9 Q86XL6 Q8TCD3
Alternative splicing: 3 isoforms:  Q12792-2   Q12792-3   Q12792-4   

Explore the universe of human proteins at neXtProt for TWF1: NX_Q12792

Explore proteomics data for TWF1 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and threonine residues1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TWF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001229326.1  NP_002813.3  

    ENSEMBL proteins: 
     ENSP00000448750   ENSP00000378886   ENSP00000446665   ENSP00000449428   ENSP00000448221  
     ENSP00000448682   ENSP00000446696   ENSP00000448230   ENSP00000321058  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: twinfilin, actin-binding protein, homolog 1 (Drosophila)
    Twinfilin subfamily

    2 InterPro protein domains:
     IPR002108 Actin-bd_cofilin/tropomyosin
     IPR028458 Twinfilin

    Graphical View of Domain Structure for InterPro Entry Q12792

    ProtoNet protein and cluster: Q12792

    1 Blocks protein domain: IPB002108 Actin-binding

    UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792
    Similarity: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily
    Similarity: Contains 2 ADF-H domains


    TWF1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TWF1_HUMAN, Q12792
    Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization,
    likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to
    play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0003785actin monomer binding ISS12807912
    GO:0004713NOT protein tyrosine kinase activity IDA10406962
    GO:0005524ATP binding IDA10406962
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS12807912
         
    TWF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TWF1:
     Decreased viability in HMC1.1  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Twf1):
     hematopoietic system  homeostasis/metabolism  integument 

    TWF1 for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-30a hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidTWF1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TWF1_HUMAN, Q12792: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Diffuse cytoplasmic localization
    with perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and
    cell-cell contacts (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    mitochondrion3
    plasma membrane2
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005911cell-cell junction ISS12807912
    GO:0015629actin cytoskeleton ISS--
    GO:0030016myofibril ISS18837697

    TWF1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TWF1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for TWF1
        Sperm Motility

    1 Cell Signaling Technology (CST) Pathway for TWF1
        Cytoskeletal Signaling




    TWF1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TWF1
    Interactions:

        Search GeneGlobe Interaction Network for TWF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TWF1 (Q127922, 3 ENSP000003210584) via UniProtKB, MINT, STRING, and/or I2D (see all 802)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    CCNB1P146352, ENSP000002564424MINT-7945693 MINT-7947479 STRING: ENSP00000256442
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    BMPR2Q138733, ENSP000003637084I2D: score=1 STRING: ENSP00000363708
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030837negative regulation of actin filament polymerization ISS12807912
    GO:0042989sequestering of actin monomers ISS18837697
    GO:0043538regulation of actin phosphorylation IDA10406962
    GO:0051016barbed-end actin filament capping IEA--

    TWF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for TWF1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TWF1 gene (3 alternative transcripts): 
    NM_001242397.1  NM_002822.4  NM_198974.1  

    Unigene Clusters for TWF1:

    Twinfilin, actin-binding protein, homolog 1 (Drosophila)
    Hs.189075  [show with all ESTs], Hs.313056  [show with all ESTs]
    Unigene Representative Sequences: NR_073472, AK291223
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552521 ENST00000395510(uc001rob.3 uc001roa.3 uc001roc.3)
    ENST00000547459(uc001rnz.3) ENST00000548315 ENST00000551789 ENST00000546662
    ENST00000550371 ENST00000548403 ENST00000546506 ENST00000547564 ENST00000547961
    ENST00000325127
    miRNA
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    hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-30a hsa-miR-4325
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    Additional mRNA sequence: 

    AK291223.1 BT019691.1 CR541736.1 CR541761.1 

    21 DOTS entries:

    DT.448246  DT.120974472  DT.91971872  DT.91755450  DT.95156465  DT.120930828  DT.97800082  DT.206393 
    DT.120908698  DT.95156471  DT.100796420  DT.86840487  DT.100661921  DT.100796417  DT.100796422  DT.121004156 
    DT.121129710  DT.121129726  DT.121303700  DT.92364444  DT.120974454 

    Selected AceView cDNA sequences (see all 293):

    AL048073 BU753364 BG287596 CB068917 BP335868 BP369418 NM_002822 AI611756 
    BU684719 AA641464 BU628554 AU131819 AU280521 BC022344 BX641865 BC068548 
    AA045040 BM695186 AI342487 AA319946 AW264917 AA261988 BE220013 CR541761 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TWF1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                                      -           -     -                 -                             -                       -                           
    SP2:                                      -     -     -     -                 -                             -                       -                           
    SP3:                                                  -     -                 -                             -                       -                           
    SP4:                                                                          -                             -                       -                           
    SP5:                                      -     -                             -                             -                                                   

    ExUns: 13
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TWF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TWF1 expression in normal human tissues (normalized intensities)      TWF1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACACAAACA
    TWF1 Expression
    About this image


    TWF1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TWF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TWF1 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.189075 Hs.313056

    UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792
    Tissue specificity: Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower
    levels in the brain, bladder and heart. Not detected in liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TWF1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Twf11 , 5 twinfilin, actin-binding protein, homolog 1 (Drosophila)1, 5 88.95(n)1
    94.86(a)1
      15 (48.59 cM)5
    192301  NM_008971.41  NP_032997.31 
     945779515 
    chicken
    (Gallus gallus)
    Aves TWF11 twinfilin, actin-binding protein, homolog 1 (Drosophila) 81.43(n)
    88.57(a)
      417797  NM_001278095.1  NP_001265024.1 
    lizard
    (Anolis carolinensis)
    Reptilia TWF16
    twinfilin actin-binding protein 1
    83(a)
    1 ↔ 1
    5(54594118-54610305)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia twf11 twinfilin actin-binding protein 1 76.57(n)
    80.29(a)
      496960  NM_001011469.1  NP_001011469.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufd02b032 wufd02b03 71.63(n)   325677  BC058050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twf1 twinfilin 52.92(n)
    49.12(a)
      41719  NM_142081.4  NP_650338.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F38E9.51 F38E9.5 46.02(n)
    35.35(a)
      181711  NM_078268.5  NP_510669.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TWF11 TWF1 43.53(n)
    30.59(a)
      852971   NP_011594.3 


    ENSEMBL Gene Tree for TWF1 (if available)
    TreeFam Gene Tree for TWF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TWF1 gene
    TWF22  
    1 SIMAP similar gene for TWF1 using alignment to 6 protein entries:     TWF1_HUMAN (see all proteins):
    TWF2

    TWF1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TWF1
    PGOHUM00000237013 PGOHUM00000241621


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TWF1 (see all 260)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132560061,2
    C,F--44187061(+) GGCGTG/AAGCCA 4 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1908523671,2
    --44187075(+) TGCCCA/GGCCCA 4 -- ds50010--------
    rs1452362011,2
    --44187099(+) CTAAAC/GCTATT 4 -- ds50010--------
    rs1826911291,2
    --44187250(+) GTCAAC/GTAAAT 4 -- ds50010--------
    rs744689331,2
    F--44187298(+) TCATGG/TCATTT 4 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1875199031,2
    --44187358(+) CACAAG/TTATTC 4 -- ds50010--------
    rs1996346421,2
    C--44187476(+) ATTAC-/ACAA  
            
    ACAAT
    4 -- ds50010--------
    rs350222341,2
    C--44187514(+) AACAG-/AACA  
            
    TACAC
    4 -- ds50011Minor allele frequency- AACA:0.00NA 2
    rs3753670401,2
    C--44187798(+) GTGTAA/GGGAAT 4 -- ut31 nc-transcript-variant0--------
    rs1924343541,2
    --44188501(+) TCTACA/GTTAGC 4 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for TWF1 (44187526 - 44200178 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TWF1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TWF1
    DNA2.0 Custom Variant and Variant Library Synthesis for TWF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610932    OMIM disorders: --

    12 diseases for TWF1:    About MalaCards
    sleeping sickness    childhood leukemia    labyrinthitis    meningioma
    tonsillitis    prostatitis    prostate cancer    thyroiditis
    leukemia    malaria    cerebritis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TWF1:
    Sleeping sickness

    TWF1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TWF1
    Human Genome Epidemiology (HuGE) Navigator: TWF1 (4 documents)

    Export disorders for TWF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TWF1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with TWF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prokaryotic expression cloning of a novel human tyrosine kinase. (PubMed id 7507208)1, 2, 3 Beeler J.F.... Aaronson S.A. (Mol. Cell. Biol. 1994)
    2. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    3. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion. (PubMed id 23224145)1 Bockhorn J....Liu H. (Breast Cancer Res. Treat. 2013)
    6. MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. (PubMed id 23340433)1 Bockhorn J....Liu H. (Nat Commun 2013)
    7. The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1 protein. (PubMed id 23940030)1 Teixeira F.R....Gomes M.D. (J. Biol. Chem. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Highly efficient purification of protein complexes from mammalian cells using a novel streptavidin-binding peptide and hexahistidine tandem tag system: application to Bruton's tyrosine kinase. (PubMed id 21080425)1 Li Y....Vondriska T.M. (Protein Sci. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5756 HGNC: 9620 AceView: PTK9 Ensembl:ENSG00000151239 euGenes: HUgn5756
    ECgene: TWF1 H-InvDB: TWF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TWF1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/073

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TWF1 gene:
    Search GeneIP for patents involving TWF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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