Aliases for TWF1 Gene
External Ids for TWF1 Gene
Previous HGNC Symbols for TWF1 Gene
Previous GeneCards Identifiers for TWF1 Gene
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008]
GeneCards Summary for TWF1 Gene
TWF1 (Twinfilin Actin Binding Protein 1) is a Protein Coding gene. Among its related pathways are Sweet Taste Signaling and Cytoskeletal Signaling. GO annotations related to this gene include protein tyrosine kinase activity and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is TWF2.
UniProtKB/Swiss-Prot for TWF1 Gene
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity).