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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TWF1 Gene

protein-coding   GIFtS: 57
GCID: GC12M044187

twinfilin, actin-binding protein, homolog 1 (Drosophila)

(Previous names: protein tyrosine kinase 9, PTK9 protein tyrosine kinase...)
(Previous symbol: PTK9)
 Explore 5 diseases affiliated with
TWF1 via our new
 Human Malady Compendium 
Biological research products
for TWF1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Twinfilin, Actin-Binding Protein, Homolog 1 (Drosophila)1 2     PTK9 Protein Tyrosine Kinase 91 2
PTK91 2 3 5     Protein A62 3
Protein Tyrosine Kinase 91 2 3     A6 Protein Tyrosine Kinase2
A61 2     Twinfilin-11

External Ids:    HGNC: 96201   Entrez Gene: 57562   Ensembl: ENSG000001512397   OMIM: 6109325   UniProtKB: Q127923   

Export aliases for TWF1 gene to outside databases

Previous GC identifers: GC12M042474 GC12M041215


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TWF1:
This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse
counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical
G-actin-rich structures may be regulated by the small GTPase RAC1. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792
Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely
by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an
important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)

Gene Wiki entry for TWF1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TWF1 gene promoter:
         GR   STAT5B   ER-alpha   AML1a   Nkx2-2   STAT5A   POU6F1 (c2)   C/EBPalpha   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTWF1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TWF1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TWF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

TWF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TWF1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M044187:  view genomic region     (about GC identifiers)

Start:
44,187,526 bp from pter      End:
44,200,178 bp from pter
Size:
12,653 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792 (See protein sequence)
Recommended Name: Twinfilin-1  
Size: 350 amino acids; 40283 Da
Subunit: Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and
phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down-regulated (By similarity)
Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Note=Diffuse cytoplasmic localization with
perinuclear and G-actin-rich cortical actin structures sublocalization. Also found at membrane ruffles and cell-cell
contacts (By similarity)
Caution: Was originally (PubMed:7507208) thought to have protein tyrosine kinase activity
Sequence caution: Sequence=AAH43148.2; Type=Erroneous initiation; Sequence=AAH68548.1; Type=Erroneous initiation;
Sequence=BAD92539.1; Type=Erroneous initiation;
Secondary accessions: A8K5A8 B3KXS6 B4DLX9 Q59G07 Q5U0B1 Q6FHJ1 Q6FHL6 Q6NUK9 Q86XL6 Q8TCD3
Alternative splicing: 3 isoforms:  Q12792-2   Q12792-3   Q12792-4   

Explore the universe of human proteins at neXtProt for TWF1: NX_Q12792

Post-translational modifications:

  • Phosphorylated on serine and threonine residues1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q12792

  • TWF1 Protein expression data from MOPED and PaxDb:    About this image 
    TWF1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001229326.1  NP_002813.3  

    ENSEMBL proteins: 
     ENSP00000448750   ENSP00000378886   ENSP00000446665   ENSP00000449428   ENSP00000448221  
     ENSP00000448682   ENSP00000446696   ENSP00000448230   ENSP00000321058  

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    Uscn Proteins for TWF1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005911cell-cell junction ISS12807912
    GO:0015629actin cytoskeleton ISS--
    GO:0030016myofibril ISS18837697

    TWF1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TWF1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002108 Actin-bd_cofilin/tropomyosin

    Graphical View of Domain Structure for InterPro Entry Q12792

    ProtoNet protein and cluster: Q12792

    1 Blocks protein family: IPB002108 Actin-binding

    UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792
    Similarity: Belongs to the actin-binding proteins ADF family. Twinfilin subfamily
    Similarity: Contains 2 ADF-H domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TWF1_HUMAN, Q12792
    Function: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely
    by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an
    important role in clathrin-mediated endocytosis and distribution of endocytic organelles (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ----
    GO:0003785actin monomer binding ISS18837697
    GO:0004713NOT protein tyrosine kinase activity IDA10406962
    GO:0005524ATP binding IDA10406962
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS12807912
         
    TWF1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TWF1:
     Decreased viability in HMC1.1  

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Twf1):
     hematopoietic system  homeostasis/metabolism  integument 

    TWF1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TWF1 

    miRNA
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    miRTarBase miRNAs that target TWF1:
    hsa-mir-126 (MIRT005538), hsa-mir-1 (MIRT005089), hsa-mir-155 (MIRT005246), hsa-mir-30a (MIRT005164)

    OriGene 3'-UTR Clone: TWF1
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    hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-30a hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidTWF1 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TWF1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    Cytoskeletal Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TWF1
        Cytoskeletal Signaling



    TWF1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TWF1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/746 Interacting proteins for TWF1 (Q127922, 3 ENSP000003210584) via UniProtKB, MINT, STRING, and/or I2D (see all 746)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC5LQ994592, ENSP000003605324MINT-7945693 MINT-7947479 STRING: ENSP00000360532
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    BMPR2Q138733, ENSP000003637084I2D: score=1 STRING: ENSP00000363708
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    IKBKEQ141643, ENSP000003560874I2D: score=1 STRING: ENSP00000356087
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030837negative regulation of actin filament polymerization ISS12807912
    GO:0042989sequestering of actin monomers ISS18837697
    GO:0043538regulation of actin phosphorylation IDA10406962
    GO:0051016barbed-end actin filament capping IEA--

    TWF1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for TWF1:
    Small Molecule - inhibitor
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TWF1 gene (3 alternative transcripts): 
    NM_001242397.1  NM_002822.4  NM_198974.1  

    Unigene Clusters for TWF1:

    Twinfilin, actin-binding protein, homolog 1 (Drosophila)
    Hs.189075  [show with all ESTs], Hs.313056  [show with all ESTs]
    Unigene Representative Sequences: NR_073472, AK291223
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000552521 ENST00000395510(uc001rob.3 uc001roa.3 uc001roc.3)
    ENST00000547459(uc001rnz.3) ENST00000548315 ENST00000551789 ENST00000546662
    ENST00000550371 ENST00000548403 ENST00000546506 ENST00000547564 ENST00000547961
    ENST00000325127

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    hsa-miR-3607-3p hsa-miR-520e hsa-miR-106a hsa-miR-30d hsa-miR-138-2* hsa-miR-519a hsa-miR-30a hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidTWF1 3' UTR sequence
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    Additional cDNA sequence: 

    AK291223.1 BT019691.1 CR541736.1 CR541761.1 

    21 DOTS entries:

    DT.448246  DT.120974472  DT.91971872  DT.91755450  DT.95156465  DT.120930828  DT.97800082  DT.206393 
    DT.120908698  DT.95156471  DT.100796420  DT.86840487  DT.100661921  DT.100796417  DT.100796422  DT.121004156 
    DT.121129710  DT.121129726  DT.121303700  DT.92364444  DT.120974454 

    24/293 AceView cDNA sequences (see all 293):

    AI923914 CD677994 AW571724 D61715 AA832321 AW848880 AU280521 CB068917 
    BE220013 BG287596 BF149340 AA045040 BP369418 BU753364 AW779781 BU628554 
    BM668998 CR541761 BU684719 BF446126 AA807169 AI342487 CB143966 AI611756 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TWF1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^
    SP1:                                      -           -     -                 -                             -                       -                           
    SP2:                                      -     -     -     -                 -                             -                       -                           
    SP3:                                                  -     -                 -                             -                       -                           
    SP4:                                                                          -                             -                       -                           
    SP5:                                      -     -                             -                             -                                                   

    ExUns: 13
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TWF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TWF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACACAAACA
    TWF1 Expression
    About this image
    See TWF1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TWF1

    SOURCE GeneReport for Unigene clusters: Hs.189075 Hs.313056

    UniProtKB/Swiss-Prot: TWF1_HUMAN, Q12792
    Tissue specificity: Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels
    in the brain, bladder and heart. Not detected in liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TWF1 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Twf11 , 5 twinfilin, actin-binding protein, homolog 1 (Drosophila)1, 5 88.95(n)1
    94.86(a)1
      15 (48.59 cM)5
    192301  NM_008971.41  NP_032997.31 
     945779515 
    chicken
    (Gallus gallus)
    Aves Q5ZLN3_CHICK6
    twinfilin
    89(a)
    1 ↔ 1
    1(31869037-31885537)
    lizard
    (Anolis carolinensis)
    Reptilia TWF16
    --
    83(a)
    1 ↔ 1
    5(54594118-54605754)
    zebrafish
    (Danio rerio)
    Actinopterygii wufd02b032 wufd02b03 71.63(n)   325677  BC058050.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta twf1 twinfilin 53.02(n)
    49.12(a)
      41719  NM_142081.3  NP_650338.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F38E9.51 Protein F38E9.5 46.02(n)
    35.35(a)
      181711  NM_078268.4  NP_510669.1 


    ENSEMBL Gene Tree for TWF1 (if available)
    TreeFam Gene Tree for TWF1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TWF1 gene
    TWF22  
    1 SIMAP similar gene for TWF1 using alignment to 6 protein entries:     TWF1_HUMAN (see all proteins):
    TWF2

    TWF1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TWF1
    PGOHUM00000237013 PGOHUM00000241621


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/209 NCBI SNPs in TWF1 are shown (see all 209    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1132560061,2
    C--44187061(+) GGCGTG/AAGCCA 2 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1908523671,2
    --44187075(+) TGCCCA/GGCCCA 2 -- ds50010--------
    rs1452362011,2
    --44187099(+) CTAAAC/GCTATT 2 -- ds50010--------
    rs1826911291,2
    --44187250(+) GTCAAC/GTAAAT 2 -- ds50010--------
    rs744689331,2
    F--44187298(+) TCATGG/TCATTT 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1875199031,2
    --44187358(+) CACAAG/TTATTC 2 -- ds50010--------
    rs1996346421,2
    --44187476(+) ATTAC-/ACAA  
            
    ACAAT
    2 -- ds50010--------
    rs350222341,2
    C--44187514(+) AACAG-/AACA  
            
    TACAC
    2 -- ds50011Minor allele frequency- AACA:0.00NA 2
    rs1924343541,2
    --44188501(+) TCTACA/GTTAGC 2 -- ut310--------
    rs1509829421,2
    --44188507(+) TTAGCC/GTGTTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TWF1 (44187526 - 44200178 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for TWF1
         2 CNVs: 86348 86347

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TWF1 for disorders           About GeneDecksing

    OMIM gene information: 610932    OMIM disorders: --

    5 diseases for TWF1:    About MalaCards
    meningioma    prostate cancer    prostatitis    immunodeficiency
    leukemia

    1 disease from the University of Copenhagen DISEASES database for TWF1:
    Sleeping sickness
    Human Genome Epidemiology (HuGE) Navigator: TWF1 (4 documents)

    Export disorders for TWF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TWF1 gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with TWF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prokaryotic expression cloning of a novel human tyrosine kinase. (PubMed id 7507208)1, 2, 3 Beeler J.F.... Aaronson S.A. (1994)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    4. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1 Rajaraman P....Inskip P.D. (2010)
    9. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1 Han S....Kang D. (2010)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5756 HGNC: 9620 AceView: PTK9 Ensembl:ENSG00000151239 euGenes: HUgn5756
    ECgene: TWF1 H-InvDB: TWF1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TWF1 Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/sptlt073.shtml

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TWF1 gene:
    Search GeneIP for patents involving TWF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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