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Aliases for TVP23C Gene

Aliases for TVP23C Gene

  • Trans-Golgi Network Vesicle Protein 23 Homolog C 2 3 5
  • Family With Sequence Similarity 18, Member B2 2 3
  • FAM18B2 3 4
  • Trans-Golgi Network Vesicle Protein 23 Homolog C (S. Cerevisiae) 2
  • Golgi Apparatus Membrane Protein TVP23 Homolog C 3
  • Protein FAM18B2 3

External Ids for TVP23C Gene

Previous HGNC Symbols for TVP23C Gene

  • FAM18B2

Previous GeneCards Identifiers for TVP23C Gene

  • GC17M015343
  • GC17M015349
  • GC17M015353

Summaries for TVP23C Gene

GeneCards Summary for TVP23C Gene

TVP23C (Trans-Golgi Network Vesicle Protein 23 Homolog C) is a Protein Coding gene. An important paralog of this gene is TVP23B.

Additional gene information for TVP23C Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TVP23C Gene

Genomics for TVP23C Gene

Regulatory Elements for TVP23C Gene

Enhancers for TVP23C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H016406 1.9 FANTOM5 Ensembl ENCODE dbSUPER 90.2 -844.1 -844080 2.2 HDGF ZNF493 ZFP64 SIN3A FEZF1 YBX1 ZNF121 GLIS2 ZNF207 KLF7 PIGL PPIAP53 NCOR1 ENSG00000266538 TVP23C MPRIP-AS1 LOC644422 ZNF286A ENSG00000264729 MEIS3P1
GH17H016377 1.7 Ensembl ENCODE dbSUPER 38.2 -816.5 -816470 4.6 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC PPARGC1A ZNF610 GLIS1 NBN ENSG00000266538 NCOR1 PPIAP53 PIGL TVP23C LOC644422 LRRC75A-AS1 FLCN ACTG1P24 ZNF286A
GH17H016456 1 ENCODE dbSUPER 41.6 -893.3 -893304 1 ZSCAN26 ZNF473 NFXL1 SALL2 RAD21 ZFHX2 ZNF366 ZNF600 EGR2 SP3 PIGL TVP23C MPRIP-AS1 ENSG00000266538 NCOR1 ZNF286A PPIAP53 LRRC75A-AS1 LOC644422 LRRC75A
GH17H016385 1.6 Ensembl ENCODE dbSUPER 23.4 -823.2 -823243 2.7 ATF1 FOXA2 ARID4B SIN3A DMAP1 GLI4 ZNF2 ZNF121 ELK1 ZNF143 PIGL ENSG00000266538 ENSG00000264729 LOC644422 TVP23C PPIAP53 ENSG00000264765 NOS2P4 COTL1P1 ENSG00000265853
GH17H016438 1.4 ENCODE dbSUPER 22.8 -877.8 -877788 6.8 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 NCOR1 PIGL PPIAP53 ENSG00000266538 LRRC75A-AS1 TVP23C LOC644422 FLCN RPL13P12 ZNF286A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TVP23C on UCSC Golden Path with GeneCards custom track

Promoters for TVP23C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for TVP23C Gene

Genomic Locations for TVP23C Gene
61,368 bases
Minus strand

Genomic View for TVP23C Gene

Genes around TVP23C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TVP23C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TVP23C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TVP23C Gene

Proteins for TVP23C Gene

  • Protein details for TVP23C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Golgi apparatus membrane protein TVP23 homolog C
    Protein Accession:
    Secondary Accessions:
    • Q3LIC7

    Protein attributes for TVP23C Gene

    276 amino acids
    Molecular mass:
    31105 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TVP23C Gene


neXtProt entry for TVP23C Gene

Post-translational modifications for TVP23C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TVP23C Gene

Domains & Families for TVP23C Gene

Gene Families for TVP23C Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TVP23C Gene

Suggested Antigen Peptide Sequences for TVP23C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TVP23 family.
  • Belongs to the TVP23 family.
genes like me logo Genes that share domains with TVP23C: view

Function for TVP23C Gene

Phenotypes From GWAS Catalog for TVP23C Gene

Phenotypes for TVP23C Gene

genes like me logo Genes that share phenotypes with TVP23C: view

Animal Model Products

CRISPR Products

miRNA for TVP23C Gene

miRTarBase miRNAs that target TVP23C

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TVP23C Gene

Localization for TVP23C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TVP23C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TVP23C gene
Compartment Confidence
golgi apparatus 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TVP23C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with TVP23C: view

Pathways & Interactions for TVP23C Gene

SuperPathways for TVP23C Gene

No Data Available

Gene Ontology (GO) - Biological Process for TVP23C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IBA --
GO:0016192 vesicle-mediated transport IBA --
genes like me logo Genes that share ontologies with TVP23C: view

No data available for Pathways by source and SIGNOR curated interactions for TVP23C Gene

Drugs & Compounds for TVP23C Gene

No Compound Related Data Available

Transcripts for TVP23C Gene

Unigene Clusters for TVP23C Gene

Trans-golgi network vesicle protein 23 homolog C (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TVP23C Gene

No ASD Table

Relevant External Links for TVP23C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TVP23C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TVP23C Gene

Protein differential expression in normal tissues from HIPED for TVP23C Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.0) and Heart (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TVP23C Gene

Protein tissue co-expression partners for TVP23C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TVP23C Gene:


SOURCE GeneReport for Unigene cluster for TVP23C Gene:

genes like me logo Genes that share expression patterns with TVP23C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TVP23C Gene

Orthologs for TVP23C Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TVP23C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 34
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 65 (a)
(Gallus gallus)
Aves FAM18B1 34
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 66 (a)
(Danio rerio)
Actinopterygii tvp23b 34
  • 56 (a)
zgc:112148 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5021 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea C34D4.4 34
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TVP23 34
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4306 34
  • 40 (a)
Species where no ortholog for TVP23C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TVP23C Gene

Gene Tree for TVP23C (if available)
Gene Tree for TVP23C (if available)

Paralogs for TVP23C Gene

Paralogs for TVP23C Gene

(5) SIMAP similar genes for TVP23C Gene using alignment to 7 proteins: Pseudogenes for TVP23C Gene

genes like me logo Genes that share paralogs with TVP23C: view

Variants for TVP23C Gene

Sequence variations from dbSNP and Humsavar for TVP23C Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000026878 -- 15,515,760(+) GTGGA(C/T)TGCAG intron-variant
rs1000028694 -- 15,561,426(+) AAACC(C/G)CATCT intron-variant
rs1000168876 -- 15,535,640(+) CAGTG(A/C)AACTC intron-variant
rs1000198754 -- 15,510,028(+) ATTTC(A/G)GAGAC intron-variant
rs1000275774 -- 15,541,720(+) TAAAC(C/T)TATGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TVP23C Gene

Variant ID Type Subtype PubMed ID
nsv962260 CNV duplication 23825009
nsv960418 CNV duplication 23825009
nsv960417 CNV duplication 23825009
nsv960057 CNV duplication 23825009
nsv574462 CNV gain 21841781
nsv457695 CNV gain 19166990
nsv1070392 CNV deletion 25765185
esv3892964 CNV gain 25118596
esv3640071 CNV gain 21293372
esv3640070 CNV loss 21293372

Variation tolerance for TVP23C Gene

Residual Variation Intolerance Score: 62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.81; 66.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TVP23C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TVP23C Gene

Disorders for TVP23C Gene

Relevant External Links for TVP23C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TVP23C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TVP23C Gene

Publications for TVP23C Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  4. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S … Mohammed S (Analytical chemistry 2009) 4 60
  5. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 60

Products for TVP23C Gene

Sources for TVP23C Gene

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