Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUT1 Gene

protein-coding   GIFtS: 49
GCID: GC11M062342

Terminal Uridylyl Transferase 1, U6 SnRNA-Specific

(Previous name: RNA binding motif protein 21)
(Previous symbol: RBM21)
  Search for TUT1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Terminal Uridylyl Transferase 1, U6 SnRNA-Specific1 2     TUTase2
RBM211 2 3     Nuclear Speckle Targeted Phosphatidylinositol 4-Phosphate 5-Kinase Type
I-Alpha Regulated-Poly(A) Polymerase2
RNA Binding Motif Protein 211 2     Nuclear Speckle-Targeted PIPK1A-Regulated-Poly(A) Polymerase2
RNA Uridylyltransferase1 2     PAP-Associated Domain-Containing 22
U6 TUTase1 2     Poly(A) Polymerase Associated Domain Containing 22
U6-TUTase2 3     Speckle Targeted PIP5K1A-Regulated Poly(A) Polymerase2
RNA-Binding Motif Protein 212 3     star-PAP2
RNA-Binding Protein 212 3     EC 2.7.7.193
U6 SnRNA-Specific Terminal Uridylyltransferase 12 3     EC 2.7.7.523
PAPD22     Star-PAP3
STARPAP2     

External Ids:    HGNC: 261841   Entrez Gene: 648522   Ensembl: ENSG000001490167   OMIM: 6106415   UniProtKB: Q9H6E53   

Export aliases for TUT1 gene to outside databases

Previous GC identifers: GC11M062099 GC11M062327


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUT1 Gene:
This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear
poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear
RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.(provided by RefSeq,
Apr 2009)

GeneCards Summary for TUT1 Gene: 
TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific) is a protein-coding gene. GO annotations related to this gene include mRNA 3'-UTR binding and RNA binding. An important paralog of this gene is ENSG00000255508.

UniProtKB/Swiss-Prot: STPAP_HUMAN, Q9H6E5
Function: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles
together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to
polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted
pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to
adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in
cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal
uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the
restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in
replication-dependent histone mRNA degradation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUT1 gene promoter:
         p53   Nkx2-5   AP-4   CUTL1   Egr-4   C/EBPalpha   CREB   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TUT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.2

TUT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUT1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M062342:  view genomic region     (about GC identifiers)

Start:
62,342,517 bp from pter      End:
62,359,649 bp from pter
Size:
17,133 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STPAP_HUMAN, Q9H6E5 (See protein sequence)
Recommended Name: Speckle targeted PIP5K1A-regulated poly(A) polymerase  
Size: 874 amino acids; 93847 Da
Cofactor: Magnesium or manganese (By similarity)
Subunit: Associates with the cleavage and polyadenylation specificity factor (CPSF) complex. Interacts with CPSF1
and CPSF3; the interaction is direct. Interacts with PIP5K1A; interaction
Subcellular location: Nucleus, nucleolus. Nucleus speckle
Sequence caution: Sequence=BAB15282.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TUT1:
2E5G (3D)    
Secondary accessions: A1A527 A8K995 Q2NL65 Q7L583 Q9H6H7

Explore the universe of human proteins at neXtProt for TUT1: NX_Q9H6E5

Explore proteomics data for TUT1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by CK1 in the proline-rich (Pro-rich) region
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H6E5

  • TUT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUT1 Protein Expression
    REFSEQ proteins: NP_073741.2  
    ENSEMBL proteins: 
     ENSP00000419607   ENSP00000278279   ENSP00000420739   ENSP00000419792   ENSP00000308000  

    Human Recombinant Protein Products for TUT1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TUT1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TUT1
    GenScript Custom Purified and Recombinant Proteins Services for TUT1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TUT1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IDA16790842
    GO:0005847colocalizes with mRNA cleavage and polyadenylation specificity factor complex IDA18305108
    GO:0016607nuclear speck IDA18288197

    TUT1 for ontologies           About GeneDecksing



    TUT1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TUT1
    GenScript Custom Superior Antibodies Services for TUT1
    Novus Biologicals TUT1 Antibody
    Abcam antibodies for TUT1
    Cloud-Clone Corp. Antibodies for TUT1 
    ThermoFisher Antibodies for TUT1
    LSBio Antibodies in human, mouse, rat for TUT1 

    Assay Products for TUT1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TUT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TUT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TUT1 
    Cloud-Clone Corp. CLIAs for TUT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR000504 RRM_dom
     IPR002058 PAP_assoc
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q9H6E5

    ProtoNet protein and cluster: Q9H6E5

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002058 PAP/25A-associated domain


    UniProtKB/Swiss-Prot: STPAP_HUMAN, Q9H6E5
    Similarity: Belongs to the DNA polymerase type-B-like family
    Similarity: Contains 1 C2H2-type zinc finger
    Similarity: Contains 1 PAP-associated domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    TUT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STPAP_HUMAN, Q9H6E5
    Function: Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles
    together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to
    polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted
    pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to
    adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in
    cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal
    uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the
    restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in
    replication-dependent histone mRNA degradation
    Catalytic activity: UTP + RNA(n) = diphosphate + RNA(n+1)
    Catalytic activity: ATP + RNA(n) = diphosphate + RNA(n+1)
    Enzyme regulation: Adenylyltransferase activity is specifically phosphatidylinositol 4,5-bisphosphate
    (PtdIns(4,5)P2)

         Enzyme Numbers (IUBMB): EC 2.7.7.191 EC 2.7.7.521

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IDA18288197
    GO:0003730mRNA 3'-UTR binding IDA--
    GO:0004652polynucleotide adenylyltransferase activity IDA18288197
         
    TUT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TUT1:
     Increased gamma-H2AX phosphory  Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TUT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUT1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUT1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TUT1:
    hsa-miR-137 hsa-miR-646
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TUT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TUT1
    Sirion Biotech Customized adenovirus for overexpression of TUT1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TUT1 (see all 11)
    OriGene ORF clones in mouse, rat for TUT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUT1 (NM_022830)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUT1
    Sirion Biotech Customized lentivirus for stable overexpression of TUT1 
                         Customized lentivirus expression plasmids for stable overexpression of TUT1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TUT1
    Search LifeMap BioReagents cell lines for TUT1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/86 Interacting proteins for TUT1 (Q9H6E52, 3 ENSP000002782794) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622582, 3MINT-7900157 I2D: score=1 
    CPSF1Q105702, ENSP000003393534MINT-8089184 MINT-8089154 MINT-8089129 STRING: ENSP00000339353
    YWHAQP273482, 3, ENSP000002380814MINT-7900157 I2D: score=1 STRING: ENSP00000238081
    CPSF3Q9UKF62, ENSP000002381124MINT-8089154 MINT-8089129 STRING: ENSP00000238112
    PRPF4O431723, ENSP000003633134I2D: score=2 STRING: ENSP00000363313
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006378mRNA polyadenylation IMP18288197
    GO:0006379mRNA cleavage IDA--
    GO:0016180snRNA processing IMP16790842
    GO:0071044NOT histone mRNA catabolic process IMP18172165

    TUT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TUT1 (STPAP)

    Search CenterWatch for drugs/clinical trials and news about TUT1 / STPAP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUT1 gene: 
    NM_022830.2  

    Unigene Cluster for TUT1:

    Terminal uridylyl transferase 1, U6 snRNA-specific
    Hs.728983  [show with all ESTs]
    Unigene Representative Sequence: NM_022830
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000476907 ENST00000469480 ENST00000463241 ENST00000278279 ENST00000494385
    ENST00000478537 ENST00000308436(uc001nto.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUT1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TUT1:
    hsa-miR-137 hsa-miR-646
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TUT1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUT1
    Clone
    Products:
         
    OriGene clones in human, mouse for TUT1 (see all 11)
    OriGene ORF clones in mouse, rat for TUT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUT1 (NM_022830)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUT1
    Sirion Biotech Customized lentivirus for stable overexpression of TUT1 
                         Customized lentivirus expression plasmids for stable overexpression of TUT1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TUT1
    OriGene qSTAR qPCR primer pairs in human, mouse for TUT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUT1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUT1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUT1

    Additional mRNA sequence: 

    AK025920.1 AK026000.1 AK292610.1 BC005013.1 BC110910.1 BC128263.1 

    16 DOTS entries:

    DT.91740219  DT.100721627  DT.120682562  DT.97825922  DT.101986113  DT.100061053  DT.91784443  DT.120682568 
    DT.91784566  DT.91784532  DT.120682788  DT.97863984  DT.120682738  DT.120682879  DT.91684727  DT.95169891 

    24/548 AceView cDNA sequences (see all 548):

    M55409 AA599985 CR590423 BF805128 CR591934 CR407625 CR618479 CR616102 
    CR599831 CR591131 BI062304 AK026000 BC007949 CR622740 CR619081 CR601463 
    BQ680228 BF907883 CR625451 CR616112 BC005013 CR618988 BM711005 AW883176 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TUT1 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14
    SP1:                          -           -                             -                 -           -                                             
    SP2:                                                                                                  -                                             
    SP3:                    -     -           -                                                                                                         
    SP4:                                                                                      -           -                                             
    SP5:                                                                                                              -     -     -     -               


    ECgene alternative splicing isoforms for TUT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCCTGAAG
    TUT1 Expression
    About this image


    See TUT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUT1

    SOURCE GeneReport for Unigene cluster: Hs.728983

    UniProtKB/Swiss-Prot: STPAP_HUMAN, Q9H6E5
    Tissue specificity: Widely expressed

        SABiosciences Custom PCR Arrays for TUT1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUT1
    OriGene qSTAR qPCR primer pairs in human, mouse for TUT1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUT1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUT1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TUT1 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tut11 , 5 terminal uridylyl transferase 1, U6 snRNA-specific1, 5 81.86(n)1
    79.23(a)1
      19 (6.04 cM)5
    700441  NM_197993.21  NP_932110.11 
     89538505 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    AAWZ02038517(1562-11132)
    zebrafish
    (Danio rerio)
    Actinopterygii tut11 terminal uridylyl transferase 1, U6 snRNA-specific 51.02(n)
    43.89(a)
      564388  NM_001030188.1  NP_001025359.1 


    ENSEMBL Gene Tree for TUT1 (if available)
    TreeFam Gene Tree for TUT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUT1 gene
    ENSG000002555082  ZCCHC62  MTPAP2  ZCCHC112  PAPD42  
    2 SIMAP similar genes for TUT1 using alignment to 5 protein entries:     STPAP_HUMAN (see all proteins):
    MIR3654    FLJ00132

    TUT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/331 SNPs in TUT1 are shown (see all 331)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413879341,2
    C--62343506(+) GTAGGC/TGCCCA 2 H R mis10--------
    rs1386964331,2
    C--62343519(+) CACCCG/AGCTGG 2 /R /W mis11Minor allele frequency- A:0.00NA 3250
    rs1425839451,2
    F--62343535(+) TTGGCT/CGCGAC 2 /A syn11Minor allele frequency- C:0.00NA 3362
    rs1507863261,2
    --62343537(+) GGCTGC/TGACAT 2 T A mis10--------
    rs1180736251,2
    C,F--62343667(+) GAGCCA/TCGAAG 2 R syn12Minor allele frequency- T:0.01NA EU 2953
    rs1127402091,2
    F--62344012(+) TAATAC/TTAGGT 1 -- int12Minor allele frequency- T:0.50CSA 4
    rs1391534581,2
    C--62344122(+) CCCCAA/GACTCA 1 -- int10--------
    rs797191671,2
    C,F--62344231(+) GAAAGT/CAAATA 1 -- int11Minor allele frequency- C:0.01WA 118
    rs1852111511,2
    --62344301(+) CAGAGC/GTGCTT 1 -- int10--------
    rs1499225091,2
    --62344452(+) ACCAGC/TAAGGT 2 L syn10--------

    HapMap Linkage Disequilibrium report for TUT1 (62342517 - 62359649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TUT1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832180CNV Loss17160897
    nsv825939CNV Gain20364138
    nsv832182CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TUT1
    DNA2.0 Custom Variant and Variant Library Synthesis for TUT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TUT1 for disorders           About MalaCards
    OMIM gene information: 610641    OMIM disorders: --


    TUT1 for disorders           About GeneDecksing


    Export disorders for TUT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUT1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with TUT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase. (PubMed id 16790842)1, 2, 3 Trippe R....Benecke B.-J. (2006)
    2. The poly A polymerase Star-PAP controls 3'-end cleavage by promoting CPSF interaction and specificity toward the pre-mRNA. (PubMed id 21102410)1, 2 Laishram R.S. and Anderson R.A. (2010)
    3. A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. (PubMed id 18288197)1, 2 Mellman D.L....Anderson R.A. (2008)
    4. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PubMed id 18172165)1, 2 Mullen T.E. and Marzluff W.F. (2008)
    5. CKIalpha is associated with and phosphorylates star-PAP and is also required for expression of select star-PAP target messenger RNAs. (PubMed id 18305108)1, 2 Gonzales M.L....Anderson R.A. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    9. The novel poly(A) polymerase Star-PAP is a signal-regu lated switch at the 3'-end of mRNAs. (PubMed id 23306079)1 Li W....Anderson R.A. (2013)
    10. Star-PAP control of BIK expression and apoptosis is re gulated by nuclear PIPKIa and PKCd signaling. (PubMed id 22244330)1 Li W....Anderson R.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64852 HGNC: 26184 AceView: EEF1GandRBM21 Ensembl:ENSG00000149016 euGenes: HUgn64852
    ECgene: TUT1 H-InvDB: TUT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUT1 gene:
    Search GeneIP for patents involving TUT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TUT1  
     OriGene qPCR primer pairs and template standards for TUT1   OriGene Protein Over-expression Lysate for TUT1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TUT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TUT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TUT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TUT1   OriGene Custom Protein Services for TUT1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUT1
     QIAGEN SeqTarget long-range PCR primers for resequencing TUT1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUT1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUT1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUT1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUT1
     GenScript Custom Purified and Recombinant Proteins Services for TUT1 GenScript cDNA clones with any tag delivered in your preferred vector for TUT1
     GenScript Custom Assay Services for TUT1 GenScript Custom Superior Antibodies Services for TUT1
     GenScript Custom overexpressing Cell Line Services for TUT1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TUT1 promoter
     Search Chromatin IP Primers for TUT1
     RT2 qPCR Primer Assay in human, mouse, rat TUT1
     Search GNC Networks for TUT1
     SABiosciences Custom PCR Arrays for TUT1
     Search Tocris compounds for TUT1 (STPAP)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TUT1 antibodies
     Antibodies for TUT1
     See all of Abcam's Antibodies, Kits and Proteins for TUT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TUT1
     Antibodies for TUT1
     ELISAs for TUT1
     CLIAs for TUT1
     Search LifeMap BioReagents cell lines for TUT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUT1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TUT1
     SwitchGear Promoter luciferase reporter plasmids for TUT1
     ThermoFisher Antibodies for TUT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUT1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TUT1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TUT1
    Customized:
     lentivirus for stable overexpression of TUT1
     lentivirus expression plasmids for stable overexpression of TUT1
     adenovirus for overexpression of TUT1
     LSBio Antibodies in human, mouse, rat for TUT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TUT1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4