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Aliases for TUT1 Gene

Aliases for TUT1 Gene

  • Terminal Uridylyl Transferase 1, U6 SnRNA-Specific 2 3
  • U6 SnRNA-Specific Terminal Uridylyltransferase 1 3 4
  • RNA Binding Motif Protein 21 2 3
  • RNA-Binding Motif Protein 21 3 4
  • RNA Uridylyltransferase 2 3
  • RNA-Binding Protein 21 3 4
  • U6 TUTase 2 3
  • U6-TUTase 3 4
  • TUTase 6 2 3
  • Star-PAP 3 4
  • RBM21 3 4
  • Nuclear Speckle Targeted Phosphatidylinositol 4-Phosphate 5-Kinase Type I-Alpha Regulated-Poly(A) Polymerase 3
  • Nuclear Speckle-Targeted PIPK1A-Regulated-Poly(A) Polymerase 3
  • Speckle Targeted PIP5K1A-Regulated Poly(A) Polymerase 3
  • Poly(A) Polymerase Associated Domain Containing 2 3
  • PAP-Associated Domain-Containing 2 3
  • Up-Regulated In Lung Cancer 6 3
  • EC 2.7.7.19 4
  • EC 2.7.7.52 4
  • STARPAP 3
  • TUTase 3
  • PAPD2 3
  • URLC6 3

External Ids for TUT1 Gene

Previous HGNC Symbols for TUT1 Gene

  • RBM21

Previous GeneCards Identifiers for TUT1 Gene

  • GC11M062099
  • GC11M062327
  • GC11M062342

Summaries for TUT1 Gene

Entrez Gene Summary for TUT1 Gene

  • This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]

GeneCards Summary for TUT1 Gene

TUT1 (Terminal Uridylyl Transferase 1, U6 SnRNA-Specific) is a Protein Coding gene. GO annotations related to this gene include RNA binding and mRNA 3-UTR binding. An important paralog of this gene is PAPD4.

UniProtKB/Swiss-Prot for TUT1 Gene

  • Poly(A) polymerase that creates the 3-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3-end cleavage of pre-mRNAs: binds to the 3UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUT1 Gene

Genomics for TUT1 Gene

Regulatory Elements for TUT1 Gene

Genomic Location for TUT1 Gene

Start:
62,575,045 bp from pter
End:
62,592,177 bp from pter
Size:
17,133 bases
Orientation:
Minus strand

Genomic View for TUT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUT1 Gene

Proteins for TUT1 Gene

  • Protein details for TUT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6E5-STPAP_HUMAN
    Recommended name:
    Speckle targeted PIP5K1A-regulated poly(A) polymerase
    Protein Accession:
    Q9H6E5
    Secondary Accessions:
    • A1A527
    • A8K995
    • Q2NL65
    • Q7L583
    • Q9H6H7

    Protein attributes for TUT1 Gene

    Size:
    874 amino acids
    Molecular mass:
    93847 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Associates with the cleavage and polyadenylation specificity factor (CPSF) complex. Interacts with CPSF1 and CPSF3; the interaction is direct. Interacts with PIP5K1A; interaction.
    SequenceCaution:
    • Sequence=BAB15282.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TUT1 Gene

neXtProt entry for TUT1 Gene

Proteomics data for TUT1 Gene at MOPED

Post-translational modifications for TUT1 Gene

Other Protein References for TUT1 Gene

No data available for DME Specific Peptides for TUT1 Gene

Domains for TUT1 Gene

Gene Families for TUT1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for TUT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6E5

UniProtKB/Swiss-Prot:

STPAP_HUMAN :
  • Q9H6E5
Domain:
  • Contains 1 PAP-associated domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the DNA polymerase type-B-like family.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with TUT1: view

Function for TUT1 Gene

Molecular function for TUT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UTP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot CatalyticActivity: ATP + RNA(n) = diphosphate + RNA(n+1).
UniProtKB/Swiss-Prot EnzymeRegulation: Adenylyltransferase activity is specifically phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2).
UniProtKB/Swiss-Prot Function: Poly(A) polymerase that creates the 3-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3-end cleavage of pre-mRNAs: binds to the 3UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

Enzyme Numbers (IUBMB) for TUT1 Gene

Gene Ontology (GO) - Molecular Function for TUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IDA 18288197
GO:0003730 mRNA 3-UTR binding IDA 21102410
GO:0004652 polynucleotide adenylyltransferase activity IDA 18288197
genes like me logo Genes that share ontologies with TUT1: view

Phenotypes for TUT1 Gene

genes like me logo Genes that share phenotypes with TUT1: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TUT1 Gene

Localization for TUT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUT1 Gene

Nucleus, nucleolus. Nucleus speckle.

Gene Ontology (GO) - Cellular Components for TUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA 16790842
GO:0005847 colocalizes_with mRNA cleavage and polyadenylation specificity factor complex IDA 18305108
GO:0016607 nuclear speck IDA 18288197
genes like me logo Genes that share ontologies with TUT1: view

No data available for Subcellular locations from COMPARTMENTS for TUT1 Gene

Pathways for TUT1 Gene

SuperPathways for TUT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IMP 18288197
GO:0006379 mRNA cleavage IDA 21102410
GO:0016180 snRNA processing IMP 16790842
GO:0071044 NOT histone mRNA catabolic process IMP 18172165
genes like me logo Genes that share ontologies with TUT1: view

No data available for Pathways by source for TUT1 Gene

Transcripts for TUT1 Gene

Unigene Clusters for TUT1 Gene

Terminal uridylyl transferase 1, U6 snRNA-specific:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUT1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14
SP1: - - - - -
SP2: -
SP3: - - -
SP4: - -
SP5: - - - -
SP6: - - - -
SP7: -
SP8: -
SP9:

Relevant External Links for TUT1 Gene

GeneLoc Exon Structure for
TUT1
ECgene alternative splicing isoforms for
TUT1

Expression for TUT1 Gene

mRNA expression in normal human tissues for TUT1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUT1 Gene

SOURCE GeneReport for Unigene cluster for TUT1 Gene Hs.728983

mRNA Expression by UniProt/SwissProt for TUT1 Gene

Q9H6E5-STPAP_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TUT1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TUT1 Gene

Orthologs for TUT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUT1 35
  • 99.67 (n)
  • 99.45 (a)
TUT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUT1 35
  • 87.73 (n)
  • 87.92 (a)
TUT1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUT1 35
  • 87.3 (n)
  • 87.57 (a)
TUT1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tut1 35
  • 81.86 (n)
  • 79.23 (a)
Tut1 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tut1 35
  • 81.46 (n)
  • 79.33 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tut1 35
  • 51.46 (n)
  • 44.07 (a)
zebrafish
(Danio rerio)
Actinopterygii tut1 35
  • 56.22 (n)
  • 51.29 (a)
tut1 36
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1091 36
  • 15 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pup-3 36
  • 18 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
Species with no ortholog for TUT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUT1 Gene

ENSEMBL:
Gene Tree for TUT1 (if available)
TreeFam:
Gene Tree for TUT1 (if available)

Paralogs for TUT1 Gene

Paralogs for TUT1 Gene

Selected SIMAP similar genes for TUT1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TUT1: view

Variants for TUT1 Gene

Sequence variations from dbSNP and Humsavar for TUT1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2512558 -- 62,592,496(+) GAGGC(C/T)GTTTC upstream-variant-2KB
rs3197864 -- 62,576,971(-) GTGAT(C/T)TATTT reference, synonymous-codon
rs3197865 - 62,576,964(-) ATTTT(C/T)TTCAG reference, missense
rs3888173 -- 62,578,659(+) TACAC(C/T)CCAGG synonymous-codon, reference
rs4963303 -- 62,590,179(+) GTTTA(C/G)GGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUT1 Gene

Variant ID Type Subtype PubMed ID
nsv832180 CNV Loss 17160897
nsv832182 CNV Gain+Loss 17160897
nsv825939 CNV Gain 20364138

Relevant External Links for TUT1 Gene

HapMap Linkage Disequilibrium report
TUT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUT1 Gene

Disorders for TUT1 Gene

No disorders were found for TUT1 Gene.

No data available for UniProtKB/Swiss-Prot for TUT1 Gene

Publications for TUT1 Gene

  1. Identification, cloning, and functional analysis of the human U6 snRNA-specific terminal uridylyl transferase. (PMID: 16790842) Trippe R. … Benecke B.-J. (RNA 2006) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PMID: 18172165) Mullen T.E. … Marzluff W.F. (Genes Dev. 2008) 3 4
  5. A PtdIns4,5P2-regulated nuclear poly(A) polymerase controls expression of select mRNAs. (PMID: 18288197) Mellman D.L. … Anderson R.A. (Nature 2008) 3 4

Products for TUT1 Gene

Sources for TUT1 Gene

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