TUSC5 Gene
protein-coding GIFtS: 45
GCID: GC17P001182
|
|
tumor suppressor candidate 5
| |
Aliases
for TUSC5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tumor Suppressor Candidate 51 2 | | Protein Located At Seventeen-P-Thirteen Point Three 12 3 | | LOST11 2 3 5 | | DSPB12 3 | | IFITMD31 2 3 | | Interferon Induced Transmembrane Protein Domain Containing 32 | | Dispanin Subfamily B Member 12 3 | | Located At Seventeen P Thirteen Point Three 12 | | Interferon-Induced Transmembrane Domain-Containing Protein D32 3 | | |
Export aliases for TUSC5 gene to outside databasesPrevious GC identifers: GC17P001390 GC17P001129 |
Summaries
for TUSC5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TUSC5_HUMAN, Q8IXB3Function: May be involved in fat metabolism (By similarity)
|
Genomic Views
for TUSC5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010718.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TUSC5 gene promoter:
Max1 CUTL1 GATA-1 C/EBPalpha PPAR-alpha PPAR-gamma1 PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TUSC5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUSC5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.3 HGNC cytogenetic band: 17p13.3TUSC5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P001182: view genomic region
(about GC identifiers)
Start:
|
1,182,957 bp from pter |
End:
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1,204,281 bp from pter |
Size:
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21,325 bases |
Orientation:
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plus strand |
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Proteins
for TUSC5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TUSC5_HUMAN, Q8IXB3 (See
protein sequence)Recommended Name: Tumor suppressor candidate 5 Size: 177 amino acids; 19254 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Developmental stage: Expressed in fetal brain
Secondary accessions: A6NMK4Explore the universe of human proteins at neXtProt for TUSC5: NX_Q8IXB3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IXB3
TUSC5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_758955.2
ENSEMBL proteins: ENSP00000329548
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TUSC5 for ontologies About GeneDecksing
TUSC5 Antibody Products:
Assay Products for TUSC5: |
Protein
Domains /
Families
for TUSC5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TUSC5 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IXB3ProtoNet protein and cluster: Q8IXB3 1 Blocks protein family: IPB007593 Interferon-induced transmembrane protein
UniProtKB/Swiss-Prot: TUSC5_HUMAN, Q8IXB3Similarity: Belongs to the CD225/Dispanin family |
Function
for TUSC5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TUSC5_HUMAN, Q8IXB3Function: May be involved in fat metabolism (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUSC5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUSC5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUSC5 |
|
Pathways & Interactions
for TUSC5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUSC5
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009607 | response to biotic stimulus |
IEA | -- |
TUSC5 for ontologies About GeneDecksing
|
Drugs & Compounds
for TUSC5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TUSC5
Search CenterWatch for drugs/clinical trials and news about TUSC5
|
Transcripts
for TUSC5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TUSC5 gene: NM_172367.2 Unigene Cluster for TUSC5: Tumor suppressor candidate 5 Hs.146059 [show with all ESTs]Unigene Representative Sequence: BC1426151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000333813(uc002fsi.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUSC5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUSC5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TUSC5 (NM_172367) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TUSC5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUSC5 |
Additional cDNA sequence: AB090231.1 AL831929.1 BC142615.1 2 DOTS entries: DT.100021165 DT.100021164 18 AceView cDNA sequences: CA428186 CB267446 CA428218 CA427116 AL831929 NM_172367 BQ694557 F36546 AW137636 F31112 BQ889856 AB090231 BX103058 CB267042 AI217120 F33988 R71820 R48900
GeneLoc Exon Structure
|
Expression
for TUSC5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TUSC5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TUSC5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUSC5
SOURCE GeneReport for Unigene cluster: Hs.146059
UniProtKB/Swiss-Prot: TUSC5_HUMAN, Q8IXB3Tissue specificity: Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle andskeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due tohypermethylation of the corresponding locus
SABiosciences Custom PCR Arrays for TUSC5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUSC5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUSC5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUSC5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUSC5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUSC5 |
Orthologs
for TUSC5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TUSC5 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TUSC51 |
tumor suppressor candidate 5 |
68.97(n)
56.92(a) |
|
417592 XM_003642432.1 XP_003642480.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
BX848340.12 |
-- |
73.16(n) |
|
BX848340.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
CR524483.26si:ch73-189b13.16 |
si:ch73-189b13.1 |
45(a)31(a) |
1 ↔ many1 ↔ many |
15(24196270-24222773) 21(38075760-38088510) |
ENSEMBL Gene Tree for TUSC5 (if available)
TreeFam Gene Tree for TUSC5 (if available) |
Paralogs
for TUSC5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TUSC5 gene
- PRRT22 TMEM2332
1 SIMAP similar gene for TUSC5 using alignment to 2 protein entries: TUSC5_HUMAN (see all proteins):TMEM233
TUSC5 for paralogs About GeneDecksing
|
Genomic Variants
for TUSC5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TUSC5 (1182957 - 1204281 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TUSC5
2 Indels: 60224 25773 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUSC5 |
|
Disorders
/ Diseases
for TUSC5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TUSC5 for disorders About GeneDecksing
OMIM gene information: 612211
OMIM disorders: --
8  diseases for TUSC5: About MalaCardsirregular astigmatism root caries astigmatism hyperopia
lissencephaly myopia lung cancer neuronitis
1 disease from the University of Copenhagen DISEASES database for TUSC5:Lissencephaly Export disorders for TUSC5 gene to outside databases
|
Publications
for TUSC5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TUSC5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TUSC5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer. (PubMed id 12660825)1, 2, 3 Konishi H.... Takahashi T. (2003)
- The dispanins: a novel gene family of ancient origin that contains 14 human members. (PubMed id 22363774)2 Sallman Almen M.... Schioth H.B. (2012)
- Characterization of Tusc5, an adipocyte gene co-expressed in peripheral neurons. (PubMed id 17689857)1 Oort P.J....Adams S.H. (2007)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Molecular cloning and characterization of rat brain endothelial cell derived gene-1 (tumor suppressor candidate 5) expressing abundantly in adipose tissues. (PubMed id 17007998)9 Shibata T....Tatsuno I. (2007)
|
External Searches for TUSC5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TUSC5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TUSC5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TUSC5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TUSC5 gene:
Search GeneIP for patents involving TUSC5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TUSC5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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 | | | TUSC5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUSC5 |
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