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Aliases for TUSC5 Gene

Aliases for TUSC5 Gene

  • Tumor Suppressor Candidate 5 2 3
  • Interferon-Induced Transmembrane Domain-Containing Protein D3 3 4
  • Interferon Induced Transmembrane Protein Domain Containing 3 2 3
  • Protein Located At Seventeen-P-Thirteen Point Three 1 3 4
  • Located At Seventeen P Thirteen Point Three 1 2 3
  • Dispanin Subfamily B Member 1 3 4
  • IFITMD3 3 4
  • DSPB1 3 4
  • LOST1 3 4

External Ids for TUSC5 Gene

Previous GeneCards Identifiers for TUSC5 Gene

  • GC17P001390
  • GC17P001129
  • GC17P001182

Summaries for TUSC5 Gene

GeneCards Summary for TUSC5 Gene

TUSC5 (Tumor Suppressor Candidate 5) is a Protein Coding gene. Diseases associated with TUSC5 include accommodative esotropia and chiasmal syndrome. An important paralog of this gene is TMEM233.

UniProtKB/Swiss-Prot for TUSC5 Gene

  • May be involved in fat metabolism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUSC5 Gene

Genomics for TUSC5 Gene

Regulatory Elements for TUSC5 Gene

Genomic Location for TUSC5 Gene

1,279,663 bp from pter
1,300,987 bp from pter
21,325 bases
Plus strand

Genomic View for TUSC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUSC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC5 Gene

Proteins for TUSC5 Gene

  • Protein details for TUSC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor suppressor candidate 5
    Protein Accession:
    Secondary Accessions:
    • A6NMK4

    Protein attributes for TUSC5 Gene

    177 amino acids
    Molecular mass:
    19254 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUSC5 Gene

Proteomics data for TUSC5 Gene at MOPED

Post-translational modifications for TUSC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUSC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUSC5 Gene

Domains & Families for TUSC5 Gene

Protein Domains for TUSC5 Gene

Suggested Antigen Peptide Sequences for TUSC5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CD225/Dispanin family.
  • Belongs to the CD225/Dispanin family.
genes like me logo Genes that share domains with TUSC5: view

No data available for Gene Families for TUSC5 Gene

Function for TUSC5 Gene

Molecular function for TUSC5 Gene

UniProtKB/Swiss-Prot Function:
May be involved in fat metabolism.

Phenotypes for TUSC5 Gene

GenomeRNAi human phenotypes for TUSC5:
genes like me logo Genes that share phenotypes with TUSC5: view

Animal Model Products

miRNA for TUSC5 Gene

miRTarBase miRNAs that target TUSC5

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUSC5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TUSC5 Gene

Localization for TUSC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUSC5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TUSC5 Gene COMPARTMENTS Subcellular localization image for TUSC5 gene
Compartment Confidence
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TUSC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TUSC5: view

Pathways & Interactions for TUSC5 Gene

SuperPathways for TUSC5 Gene

No Data Available

Interacting Proteins for TUSC5 Gene

Gene Ontology (GO) - Biological Process for TUSC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009607 response to biotic stimulus IEA --
genes like me logo Genes that share ontologies with TUSC5: view

No data available for Pathways by source and SIGNOR curated interactions for TUSC5 Gene

Drugs & Compounds for TUSC5 Gene

No Compound Related Data Available

Transcripts for TUSC5 Gene

mRNA/cDNA for TUSC5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUSC5 Gene

Tumor suppressor candidate 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUSC5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC5 Gene

No ASD Table

Relevant External Links for TUSC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUSC5 Gene

mRNA expression in normal human tissues for TUSC5 Gene

mRNA differential expression in normal tissues according to GTEx for TUSC5 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x17.1), Adipose - Subcutaneous (x15.4), and Breast - Mammary Tissue (x8.9).

Protein differential expression in normal tissues from HIPED for TUSC5 Gene

This gene is overexpressed in Adipocyte (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TUSC5 Gene

SOURCE GeneReport for Unigene cluster for TUSC5 Gene Hs.146059

mRNA Expression by UniProt/SwissProt for TUSC5 Gene

Tissue specificity: Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus.
genes like me logo Genes that share expression patterns with TUSC5: view

Protein tissue co-expression partners for TUSC5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TUSC5 Gene

Orthologs for TUSC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TUSC5 35
  • 81.92 (n)
  • 71.19 (a)
TUSC5 36
  • 71 (a)
(Canis familiaris)
Mammalia TUSC5 35
  • 82.49 (n)
  • 77.4 (a)
TUSC5 36
  • 76 (a)
(Mus musculus)
Mammalia Tusc5 35
  • 81.31 (n)
  • 76.3 (a)
Tusc5 16
Tusc5 36
  • 74 (a)
(Pan troglodytes)
Mammalia TUSC5 35
  • 97.55 (n)
  • 95.48 (a)
TUSC5 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Tusc5 35
  • 82.08 (n)
  • 78.03 (a)
(Monodelphis domestica)
Mammalia TUSC5 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia TUSC5 36
  • 51 (a)
(Gallus gallus)
Aves TUSC5 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tusc5 35
  • 62.03 (n)
  • 50.43 (a)
(Danio rerio)
Actinopterygii LOC101886018 35
  • 53.83 (n)
  • 40.74 (a)
TUSC5 36
  • 34 (a)
Species with no ortholog for TUSC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUSC5 Gene

Gene Tree for TUSC5 (if available)
Gene Tree for TUSC5 (if available)

Paralogs for TUSC5 Gene

Paralogs for TUSC5 Gene

(1) SIMAP similar genes for TUSC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TUSC5: view

Variants for TUSC5 Gene

Sequence variations from dbSNP and Humsavar for TUSC5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs877774 -- 1,295,538(+) AGGCT(A/G)GGCCG synonymous-codon, reference
rs902965 -- 1,295,334(+) CGGGG(A/G)CAGCC intron-variant
rs1472181 -- 1,295,205(+) GCCAC(C/T)GCCAC intron-variant
rs2101687 -- 1,295,130(+) GGGGC(A/G)CCTGG intron-variant
rs3926577 -- 1,294,883(+) gtttc(A/T)ccatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUSC5 Gene

Variant ID Type Subtype PubMed ID
nsv907493 CNV Loss 21882294
nsv907497 CNV Loss 21882294
nsv509645 CNV Insertion 20534489
esv2715442 CNV Deletion 23290073
esv1777284 CNV Deletion 17803354
esv2715443 CNV Deletion 23290073
esv2715444 CNV Deletion 23290073
esv2715445 CNV Deletion 23290073
esv6254 CNV Gain 19470904

Variation tolerance for TUSC5 Gene

Residual Variation Intolerance Score: 83.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUSC5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUSC5 Gene

Disorders for TUSC5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TUSC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
accommodative esotropia
  • esotropia with accommodative compensation
chiasmal syndrome
  • chiasma syndrome
eye accommodation disease
regular astigmatism
- elite association
Search TUSC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TUSC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TUSC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUSC5 Gene

Publications for TUSC5 Gene

  1. Molecular cloning and characterization of rat brain endothelial cell derived gene-1 (tumor suppressor candidate 5) expressing abundantly in adipose tissues. (PMID: 17007998) Shibata T. … Tatsuno I. (Mol. Cell. Endocrinol. 2007) 23 67
  2. Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at distal 17p13.3 in human lung cancer. (PMID: 12660825) Konishi H. … Takahashi T. (Oncogene 2003) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. The dispanins: a novel gene family of ancient origin that contains 14 human members. (PMID: 22363774) Sallman Almen M. … Schioth H.B. (PLoS ONE 2012) 67
  5. Hypermethylation of TUSC5 genes in breast cancer tissue. (PMID: 23302999) Bubnov V. … Zaporozhan V. (Exp. Oncol. 2012) 67

Products for TUSC5 Gene

Sources for TUSC5 Gene

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