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TUSC3 Gene

protein-coding   GIFtS: 61
GCID: GC08P015274

Tumor Suppressor Candidate 3

  See TUSC3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Suppressor Candidate 31 2     MRT72 5
Magnesium Uptake/Transporter TUSC32 3     Oligosaccharyltransferase 3 Homolog A (S. Cerevisiae)1
N332 3     OST3A2
D8S19922 5     Oligosaccharyltransferase 3 Homolog A2
M332 5     Putative Prostate Cancer Tumor Suppressor2
MRT222 5     Protein N333

External Ids:    HGNC: 302421   Entrez Gene: 79912   Ensembl: ENSG000001047237   OMIM: 6013855   UniProtKB: Q134543   

Export aliases for TUSC3 gene to outside databases

Previous GC identifers: GC08P015408 GC08P015442 GC08P013941


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TUSC3 Gene:
This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic
prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and
colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding
distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TUSC3 Gene:
TUSC3 (tumor suppressor candidate 3) is a protein-coding gene. Diseases associated with TUSC3 include prostate cancer, and mental retardation, autosomal recessive 43. GO annotations related to this gene include magnesium ion transmembrane transporter activity and dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is MAGT1.

UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
Function: Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl
transferase

Gene Wiki entry for TUSC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_167187.2  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUSC3 gene promoter:
         Nkx3-1   FOXD3   Nkx3-1 v1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Nkx3-1 v2   AREB6   Nkx3-1 v3   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUSC3 promoter sequence
   Search Chromatin IP Primers for TUSC3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUSC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

TUSC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUSC3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P015274:  view genomic region     (about GC identifiers)

Start:
15,274,724 bp from pter      End:
15,624,158 bp from pter
Size:
349,435 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454 (See protein sequence)
Recommended Name: Tumor suppressor candidate 3 precursor  
Size: 348 amino acids; 39676 Da
Subunit: Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least
RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B (By similarity)
Secondary accessions: A8MSM0 D3DSP2 Q14911 Q14912 Q96FW0
Alternative splicing: 2 isoforms:  Q13454-1   Q13454-2   

Explore the universe of human proteins at neXtProt for TUSC3: NX_Q13454

Explore proteomics data for TUSC3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys180
  • Modification sites at PhosphoSitePlus

  • See TUSC3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_006756.2  NP_839952.1  

    ENSEMBL proteins: 
     ENSP00000371450   ENSP00000420829   ENSP00000425777   ENSP00000426973   ENSP00000423426  
     ENSP00000424544   ENSP00000426880  
    Reactome Protein details: Q13454

    TUSC3 Human Recombinant Protein Products:

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    Novus Biologicals TUSC3 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TUSC3

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR012336 Thioredoxin-like_fold
     IPR021149 OligosaccharylTrfase_OST3/OST6
     IPR006844 Mg_transporter-1
     IPR013766 Thioredoxin_domain

    Graphical View of Domain Structure for InterPro Entry Q13454

    ProtoNet protein and cluster: Q13454

    1 Blocks protein domain: IPB006844 OST3/OST6

    UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
    Similarity: Belongs to the OST3/OST6 family
    Similarity: Contains 1 thioredoxin domain


    Find genes that share domains with TUSC3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TUSC3_HUMAN, Q13454
    Function: Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl
    transferase

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS--
    GO:0015095magnesium ion transmembrane transporter activity IMP19717468
         
    Find genes that share ontologies with TUSC3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TUSC3:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUSC3
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUSC3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TUSC3:
    hsa-mir-1229-3p (MIRT036380), hsa-mir-128-3p (MIRT022014), hsa-mir-26b-5p (MIRT029507), hsa-mir-25-3p (MIRT050240)

    Block miRNA regulation of human, mouse, rat TUSC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUSC3 (see all 45):
    hsa-miR-2052 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-605 hsa-miR-30d hsa-miR-3122 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTUSC3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat TUSC3

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    GenScript: all cDNA clones in your preferred vector (see all 2): TUSC3 (NM_178234)
    Sino Biological Human cDNA Clone for TUSC3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUSC3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TUSC3_HUMAN, Q13454: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    plasma membrane5
    mitochondrion4
    golgi apparatus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005887integral component of plasma membrane NAS19717468
    GO:0008250oligosaccharyltransferase complex IDA15835887

    Find genes that share ontologies with TUSC3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUSC3 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Post-translational protein modification0.43
    N-Glycan biosynthesis0.49
    Metabolism of proteins0.30
    2Metabolism
    Metabolic pathways0.38
    3Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with TUSC3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for TUSC3
        Asparagine N-linked glycosylation


    3 Kegg Pathways  (Kegg details for TUSC3):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUSC3
    Interactions:

        Search GeneGlobe Interaction Network for TUSC3

    1 Interacting protein for TUSC3 (Q134542, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3MINT-62210 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation NAS18455129
    GO:0015693magnesium ion transport IMP19717468
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with TUSC3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TUSC3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUSC3 gene (2 alternative transcripts): 
    NM_006765.3  NM_178234.2  

    Unigene Clusters for TUSC3:

    Tumor suppressor candidate 3
    Hs.426324  [show with all ESTs], Hs.600825  [show with all ESTs]
    Unigene Representative Sequences: AK026149, NM_006765
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503191 ENST00000382020(uc003wwt.3 uc003wwu.3 uc022asi.1)
    ENST00000515859 ENST00000506802 ENST00000510836 ENST00000509380 ENST00000503731
    ENST00000507400 ENST00000509177 ENST00000511783 ENST00000508446 ENST00000507316
    ENST00000511342
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TUSC3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUSC3 (see all 45):
    hsa-miR-2052 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-605 hsa-miR-30d hsa-miR-3122 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTUSC3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TUSC3
    Predesigned siRNA for gene silencing in human, mouse, rat TUSC3
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    OriGene ORF clones in mouse, rat for TUSC3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TUSC3 (NM_178234)
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    Primer
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    OriGene qPCR primer pairs and template standards for TUSC3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUSC3
      QuantiTect SYBR Green Assays in human, mouse, rat TUSC3
      QuantiFast Probe-based Assays in human, mouse, rat TUSC3

    Additional mRNA sequence: 

    AY530159.1 AY562998.1 AY562999.1 BC010370.1 BT020002.1 U42349.1 

    Selected DOTS entries (see all 26):

    DT.92456038  DT.100753417  DT.95086803  DT.100847280  DT.92456030  DT.99964495  DT.100767843  DT.100847278 
    DT.95196503  DT.75110033  DT.100847284  DT.206935  DT.92010952  DT.92456045  DT.75163196  DT.70100189 
    DT.100847286  DT.75193376  DT.100708459  DT.95207136  DT.100834367  DT.101955669  DT.120644104  DT.92456049 

    Selected AceView cDNA sequences (see all 403):

    BU176442 CR615974 AA129069 BI963063 BE350861 AA781269 AA902372 CR608157 
    CA454970 AA991301 CR603895 AA129070 CR607966 T41075 BQ632422 AU134136 
    NM_178234 BM720762 BP380031 CR624122 AI435388 AY530159 CA416968 CR602882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUSC3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATTATGA
    TUSC3 Expression
    About this image


    TUSC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Ovary (Reproductive System)
     
     Adrenal Gland (Endocrine System)
     
     Placenta (Extraembryonic Tissues)
    TUSC3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUSC3 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.426324 Hs.600825

    UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
    Tissue specificity: Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver,
    colon, heart, kidney and pancreas

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUSC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TUSC3 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tusc31 , 5 tumor suppressor candidate 31, 5 90.78(n)1
    98.56(a)1
      8 (23.89 cM)5
    802861  NM_030254.31  NP_084530.31 
     390058675 
    chicken
    (Gallus gallus)
    Aves TUSC31 tumor suppressor candidate 3 82(n)
    94.57(a)
      422738  XM_420692.4  XP_420692.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUSC36
    tumor suppressor candidate 3
    88(a)
    1 ↔ 1
    5(107215684-107441841)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.192742 Xenopus laevis transcribed sequence with moderate similarity more 80.28(n)    CD302184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125442 Transcribed sequence with moderate similarity to protein more 77.22(n)    CK354406.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ostgamma1 Oligosaccharide transferase gamma subunit 60.13(n)
    58.2(a)
      34137  NM_135360.4  NP_609204.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK686.31 ZK686.3 54.5(n)
    48.68(a)
      176089  NM_066290.4  NP_498691.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OST31 OST3 43.73(n)
    23.93(a)
      854252   NP_014728.1 


    ENSEMBL Gene Tree for TUSC3 (if available)
    TreeFam Gene Tree for TUSC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUSC3 gene
    MAGT12  
    1 SIMAP similar gene for TUSC3 using alignment to 7 protein entries:     TUSC3_HUMAN (see all proteins):
    MAGT1

    Find genes that share paralogs with TUSC3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUSC3 (see all 6727)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs715007121,2
    C--13959198(+) AAAGGG/CATTGG 2 -- int11Minor allele frequency- C:0.00NA 2
    rs106239811,2
    C--13971559(+) AATTT-/AATTAAA 2 -- int10--------
    rs349850881,2
    C--13971561(+) ATTTT-/AATAAAT 2 -- int10--------
    rs715416921,2
    C--13974888(+) ATATA-/TATATA/
    TATATATATA
    TATAT
    2 -- int11NA 2
    rs3776832671,2
    C--13983789(+) ACTCC-/TGACCC 2 -- int10--------
    rs58895861,2
    C--13993013(+) CACTT-/AGAA  
            
    AGGCT
    2 -- int10--------
    rs1400293551,2
    C--14004357(+) TTATA-/TGTG  
            
    TGTGT
    2 -- int10--------
    rs1407990211,2
    C--14011442(+) ACATT-/AATAAAA 2 -- int10--------
    rs722954541,2
    C--14011444(+) CATTT-/AAAAAAA 2 -- int10--------
    rs1114300301,2
    C--14014926(+) AGTGC-/T/TT  
            
    TTTTT
    2 -- int11CSA 2

    HapMap Linkage Disequilibrium report for TUSC3 (15274724 - 15524724 bp, first 250kb of TUSC3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TUSC3 (see all 59):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2736658CNV Deletion23290073
    esv2736659CNV Deletion23290073
    esv2672142CNV Deletion23128226
    esv2193216CNV Deletion18987734
    esv2421867CNV Deletion20811451
    esv2736660CNV Deletion23290073
    esv2656774CNV Deletion23128226
    esv2421337CNV Deletion20811451
    esv2736657CNV Deletion23290073
    esv4612CNV Deletion18987735

    Human Gene Mutation Database (HGMD): TUSC3
    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing TUSC3:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing TUSC3
    DNA2.0 Custom Variant and Variant Library Synthesis for TUSC3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601385   
    OMIM disorders: 611093  
    UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
  • Mental retardation, autosomal recessive 7 (MRT7) [MIM:611093]: A disorder characterized by significantly
    below average general intellectual functioning associated with impairments in adaptive behavior and manifested
    during the developmental period. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 2 diseases for TUSC3:    
    About MalaCards
    prostate cancer    mental retardation, autosomal recessive 43


    Find genes that share disorders with TUSC3           About GenesLikeMe

    Genetic Association Database (GAD): TUSC3

    Export disorders for TUSC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TUSC3 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with TUSC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22. (PubMed id 8661104)1, 2, 3 Macgrogan D.... Bookstein R. (Genomics 1996)
    2. A defect in the TUSC3 gene is associated with autosomal recessive mental retardation. (PubMed id 18452889)1, 2, 9 Garshasbi M.... Kuss A.W. (Am. J. Hum. Genet. 2008)
    3. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
    4. Mammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic development. (PubMed id 19717468)1, 2 Zhou H. and Clapham D.E. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation. (PubMed id 18455129)1, 2 Molinari F.... Colleaux L. (Am. J. Hum. Genet. 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (Mol. Cell 2003)
    8. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. (PubMed id 10097140)1, 3 Ishii H.... Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    9. Homozygous deletion in TUSC3 causing syndromic intellectual disability: a new patient. (PubMed id 23825019)1 Loddo S....Battaglia A. (Am. J. Med. Genet. A 2013)
    10. Evidence for shared genetic risk between methamphetamine-induced psychosis and schizophrenia. (PubMed id 23594818)1 Ikeda M....Iwata N. (Neuropsychopharmacology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7991 HGNC: 30242 AceView: TUSC3 Ensembl:ENSG00000104723 euGenes: HUgn7991
    ECgene: TUSC3 Kegg: 7991 H-InvDB: TUSC3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TUSC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TUSC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TUSC3 gene:
    Search GeneIP for patents involving TUSC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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