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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUSC3 Gene

protein-coding   GIFtS: 60
GCID: GC08P015274

Tumor Suppressor Candidate 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tumor Suppressor Candidate 31 2     Oligosaccharyltransferase 3 Homolog A (S. Cerevisiae)1
Magnesium Uptake/Transporter TUSC32 3     MRT222
N332 3     OST3A2
D8S19922 5     Oligosaccharyltransferase 3 Homolog A2
M332 5     Putative Prostate Cancer Tumor Suppressor2
MRT72 5     Protein N333

External Ids:    HGNC: 302421   Entrez Gene: 79912   Ensembl: ENSG000001047237   OMIM: 6013855   UniProtKB: Q134543   

Export aliases for TUSC3 gene to outside databases

Previous GC identifers: GC08P015408 GC08P015442 GC08P013941


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUSC3 Gene:
This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic
prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and
colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding
distinct isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TUSC3 Gene: 
TUSC3 (tumor suppressor candidate 3) is a protein-coding gene. Diseases associated with TUSC3 include prostate cancer, and botulism, and among its related super-pathways are WNT ligand biogenesis and trafficking and Signaling by GPCR. GO annotations related to this gene include magnesium ion transmembrane transporter activity and dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is MAGT1.

UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
Function: Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl
transferase

Gene Wiki entry for TUSC3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUSC3 gene promoter:
         Nkx3-1   FOXD3   Nkx3-1 v1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   Nkx3-1 v2   AREB6   Nkx3-1 v3   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUSC3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TUSC3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUSC3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22

TUSC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUSC3 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P015274:  view genomic region     (about GC identifiers)

Start:
15,274,724 bp from pter      End:
15,624,158 bp from pter
Size:
349,435 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454 (See protein sequence)
Recommended Name: Tumor suppressor candidate 3 precursor  
Size: 348 amino acids; 39676 Da
Subunit: Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least
RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: A8MSM0 D3DSP2 Q14911 Q14912 Q96FW0
Alternative splicing: 2 isoforms:  Q13454-1   Q13454-2   

Explore the universe of human proteins at neXtProt for TUSC3: NX_Q13454

Explore proteomics data for TUSC3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13454

  • TUSC3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUSC3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_006756.2  NP_839952.1  

    ENSEMBL proteins: 
     ENSP00000371450   ENSP00000420829   ENSP00000425777   ENSP00000426973   ENSP00000423426  
     ENSP00000424544   ENSP00000426880  
    Reactome Protein details: Q13454
    Human Recombinant Protein Products for TUSC3: 
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    Cloud-Clone Corp. Proteins for TUSC3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005887integral to plasma membrane NAS19717468
    GO:0008250oligosaccharyltransferase complex IDA15835887

    TUSC3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR006844 Mg_transporter-1
     IPR013766 Thioredoxin_domain
     IPR012336 Thioredoxin-like_fold
     IPR021149 OligosaccharylTrfase_OST3/OST6

    Graphical View of Domain Structure for InterPro Entry Q13454

    ProtoNet protein and cluster: Q13454

    1 Blocks protein domain: IPB006844 OST3/OST6

    UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
    Similarity: Belongs to the OST3/OST6 family
    Similarity: Contains 1 thioredoxin domain


    TUSC3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TUSC3_HUMAN, Q13454
    Function: Magnesium transporter. May be involved in N-glycosylation through its association with N-oligosaccharyl
    transferase

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity ISS--
    GO:0015095magnesium ion transmembrane transporter activity IMP19717468
         
    TUSC3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TUSC3:
     Increased S DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUSC3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUSC3 
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    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate TUSC3 (see all 45):
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    SwitchGear 3'UTR luciferase reporter plasmidTUSC3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUSC3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2Signaling by GPCR
    Signal Transduction0.55
    3Metabolism
    Metabolic pathways0.40
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for TUSC3 (see all 6)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    Signal Transduction
    Metabolism of proteins
    Post-translational protein modification


    3         Kegg Pathways  (Kegg details for TUSC3):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum


    TUSC3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUSC3

    1 Interacting protein for TUSC3 (Q134542, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1CAP621362, 3MINT-62210 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006487protein N-linked glycosylation NAS18455129
    GO:0015693magnesium ion transport IMP19717468
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    TUSC3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TUSC3

    Search CenterWatch for drugs/clinical trials and news about TUSC3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUSC3 gene (2 alternative transcripts): 
    NM_006765.3  NM_178234.2  

    Unigene Clusters for TUSC3:

    Tumor suppressor candidate 3
    Hs.426324  [show with all ESTs], Hs.600825  [show with all ESTs]
    Unigene Representative Sequences: AK026149, NM_006765
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503191 ENST00000382020(uc003wwt.3 uc003wwu.3 uc022asi.1)
    ENST00000515859 ENST00000506802 ENST00000510836 ENST00000509380 ENST00000503731
    ENST00000507400 ENST00000509177 ENST00000511783 ENST00000508446 ENST00000507316
    ENST00000511342
    miRNA
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    hsa-miR-2052 hsa-miR-520e hsa-miR-302d hsa-miR-520f hsa-miR-605 hsa-miR-30d hsa-miR-3122 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTUSC3 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AY530159.1 AY562998.1 AY562999.1 BC010370.1 BT020002.1 U42349.1 

    24/26 DOTS entries (see all 26):

    DT.92456038  DT.100753417  DT.95086803  DT.100847280  DT.92456030  DT.99964495  DT.100767843  DT.100847278 
    DT.95196503  DT.75110033  DT.100847284  DT.206935  DT.92010952  DT.92456045  DT.75163196  DT.70100189 
    DT.100847286  DT.75193376  DT.100708459  DT.95207136  DT.100834367  DT.101955669  DT.120644104  DT.92456049 

    24/403 AceView cDNA sequences (see all 403):

    CR608785 AY562999 CR626212 BX379859 W58689 CR615904 BM874503 CR619540 
    AA371029 BU069211 BG621890 CR603479 CR609898 AA635975 BQ720428 BU783774 
    CR611813 AI500547 CR603864 AI753097 AU119983 AI929148 CR603172 CD676717 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUSC3 expression in normal human tissues (normalized intensities)      TUSC3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAATTATGA
    TUSC3 Expression
    About this image


    TUSC3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             brain/midbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Placenta (Extraembryonic Tissues)
     
     Spinal Cord (Nervous System)

     -- (Nervous System)
             mouse/organ system/nervous system/central nervous system   

    See TUSC3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUSC3

    SOURCE GeneReport for Unigene clusters: Hs.426324 Hs.600825

    UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
    Tissue specificity: Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver,
    colon, heart, kidney and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUSC3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TUSC3 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tusc31 , 5 tumor suppressor candidate 31, 5 90.78(n)1
    98.56(a)1
      8 (23.89 cM)5
    802861  NM_030254.31  NP_084530.31 
     390058675 
    chicken
    (Gallus gallus)
    Aves TUSC31 tumor suppressor candidate 3 81.58(n)
    92.49(a)
      422738  XM_420692.3  XP_420692.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUSC36
    tumor suppressor candidate 3
    88(a)
    1 ↔ 1
    5(107215684-107441841)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.192742 Xenopus laevis transcribed sequence with moderate similarity more 80.28(n)    CD302184.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.125442 Transcribed sequence with moderate similarity to protein more 77.22(n)    CK354406.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78301 CG7830 59.96(n)
    57.86(a)
      34137  NM_135360.3  NP_609204.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK686.31 Protein ZK686.3 54.61(n)
    48.68(a)
      176089  NM_066290.3  NP_498691.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OST36
    Gamma subunit of the oligosaccharyltransferase com...
    19(a)
    1 → many
    XV(482033-483085)


    ENSEMBL Gene Tree for TUSC3 (if available)
    TreeFam Gene Tree for TUSC3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUSC3 gene
    MAGT12  
    1 SIMAP similar gene for TUSC3 using alignment to 7 protein entries:     TUSC3_HUMAN (see all proteins):
    MAGT1

    TUSC3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6727 SNPs in TUSC3 are shown (see all 6727)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0693694
    ----see VAR_0693692 M V mis40--------
    rs715007121,2
    C--13959198(+) AAAGGG/CATTGG 2 -- int11Minor allele frequency- C:0.00NA 2
    rs106239811,2
    C--13971559(+) AATTT-/AATTAAA 2 -- int10--------
    rs349850881,2
    C--13971561(+) ATTTT-/AATAAAT 2 -- int10--------
    rs715416921,2
    C--13974888(+) ATATA-/TATATA/
    TATATATATA
    TATAT
    2 -- int11NA 2
    rs3776832671,2
    C--13983789(+) ACTCC-/TGACCC 2 -- int10--------
    rs58895861,2
    C--13993013(+) CACTT-/AGAA  
            
    AGGCT
    2 -- int10--------
    rs1400293551,2
    C--14004357(+) TTATA-/TGTG  
            
    TGTGT
    2 -- int10--------
    rs1407990211,2
    C--14011442(+) ACATT-/AATAAAA 2 -- int10--------
    rs722954541,2
    C--14011444(+) CATTT-/AAAAAAA 2 -- int10--------

    HapMap Linkage Disequilibrium report for TUSC3 (15274724 - 15524724 bp, first 250kb of TUSC3)

    Structural Variations
         Database of Genomic Variants (DGV) 10/59 variations for TUSC3 (see all 59):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2736658CNV Deletion23290073
    esv2736659CNV Deletion23290073
    esv2672142CNV Deletion23128226
    esv2193216CNV Deletion18987734
    esv2421867CNV Deletion20811451
    esv2736660CNV Deletion23290073
    esv2656774CNV Deletion23128226
    esv2421337CNV Deletion20811451
    esv2736657CNV Deletion23290073
    esv4612CNV Deletion18987735


    Human Gene Mutation Database (HGMD): TUSC3
    SABiosciences Cancer Mutation PCR Assays
    1 SABiosciences qBiomarker Copy Number PCR Array containing TUSC3:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing TUSC3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601385   
    OMIM disorders: 611093  
    UniProtKB/Swiss-Prot: TUSC3_HUMAN, Q13454
  • Mental retardation, autosomal recessive 7 (MRT7) [MIM:611093]: A disorder characterized by significantly
    below average general intellectual functioning associated with impairments in adaptative behavior and manifested
    during the developmental period. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 8 diseases for TUSC3:    About MalaCards
    prostate cancer    botulism    prostatitis    congenital disorder of glycosylation
    intellectual disability    non-small cell lung carcinoma    mental retardation    ulcerative colitis


    TUSC3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TUSC3

    Export disorders for TUSC3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUSC3 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with TUSC3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22. (PubMed id 8661104)1, 2, 3 Macgrogan D.... Bookstein R. (1996)
    2. A defect in the TUSC3 gene is associated with autosomal recessive mental retardation. (PubMed id 18452889)1, 2, 9 Garshasbi M....Kuss A.W. (2008)
    3. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (2012)
    4. Mammalian MagT1 and TUSC3 are required for cellular m agnesium uptake and vertebrate embryonic development. (PubMed id 19717468)1, 2 Zhou H. and Clapham D.E. (2009)
    5. Oligosaccharyltransferase-subunit mutations in nonsyndromic mental retardation. (PubMed id 18455129)1, 2 Molinari F.... Colleaux L. (2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. (PubMed id 12887896)1, 2 Kelleher D.J.... Gilmore R. (2003)
    8. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. (PubMed id 10097140)1, 3 Ishii H.... Croce C.M. (1999)
    9. Evidence for shared genetic risk between methamphetami ne-induced psychosis and schizophrenia. (PubMed id 23594818)1 Ikeda M....Iwata N. (2013)
    10. Loss of the oligosaccharyl transferase subunit TUSC3 p romotes proliferation and migration of ovarian cancer cells. (PubMed id 23404293)1 Vanhara P....Krainer M. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7991 HGNC: 30242 AceView: TUSC3 Ensembl:ENSG00000104723 euGenes: HUgn7991
    ECgene: TUSC3 Kegg: 7991 H-InvDB: TUSC3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUSC3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TUSC3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUSC3 gene:
    Search GeneIP for patents involving TUSC3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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