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Aliases for TUSC3 Gene

Aliases for TUSC3 Gene

  • Tumor Suppressor Candidate 3 2 3 5
  • Magnesium Uptake/Transporter TUSC3 3 4
  • N33 3 4
  • Oligosaccharyltransferase 3 Homolog A (S. Cerevisiae) 2
  • Putative Prostate Cancer Tumor Suppressor 3
  • Oligosaccharyltransferase 3 Homolog A 3
  • Protein N33 4
  • D8S1992 3
  • MRT22 3
  • OST3A 3
  • MRT7 3
  • M33 3

External Ids for TUSC3 Gene

Previous GeneCards Identifiers for TUSC3 Gene

  • GC08P015408
  • GC08P015442
  • GC08P015274
  • GC08P013941

Summaries for TUSC3 Gene

Entrez Gene Summary for TUSC3 Gene

  • This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer. The gene is expressed in most nonlymphoid human tissues including prostate, lung, liver, and colon. Expression was also detected in many epithelial tumor cell lines. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUSC3 Gene

TUSC3 (Tumor Suppressor Candidate 3) is a Protein Coding gene. Diseases associated with TUSC3 include 46Xy Sex Reversal 5 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include magnesium ion transmembrane transporter activity and dolichyl-diphosphooligosaccharide-protein glycotransferase activity. An important paralog of this gene is MAGT1.

UniProtKB/Swiss-Prot for TUSC3 Gene

  • Magnesium transporter (PubMed:19717468). May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (PubMed:24685145).

Gene Wiki entry for TUSC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUSC3 Gene

Genomics for TUSC3 Gene

Regulatory Elements for TUSC3 Gene

Enhancers for TUSC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TUSC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUSC3 Gene

15,417,215 bp from pter
15,766,649 bp from pter
349,435 bases
Plus strand

Genomic View for TUSC3 Gene

Genes around TUSC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUSC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUSC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC3 Gene

Proteins for TUSC3 Gene

  • Protein details for TUSC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor suppressor candidate 3
    Protein Accession:
    Secondary Accessions:
    • A8MSM0
    • D3DSP2
    • Q14911
    • Q14912
    • Q96FW0

    Protein attributes for TUSC3 Gene

    348 amino acids
    Molecular mass:
    39676 Da
    Quaternary structure:
    • Weakly associates with the oligosaccharyl transferase (OST) complex which contains at least RPN1/ribophorin I, RPN2/ribophorin II, OST48, DAD1, and either STT3A or STT3B.

    Three dimensional structures from OCA and Proteopedia for TUSC3 Gene

    Alternative splice isoforms for TUSC3 Gene


neXtProt entry for TUSC3 Gene

Proteomics data for TUSC3 Gene at MOPED

Post-translational modifications for TUSC3 Gene

  • Ubiquitination at Lys 180
  • Modification sites at PhosphoSitePlus

Other Protein References for TUSC3 Gene

No data available for DME Specific Peptides for TUSC3 Gene

Domains & Families for TUSC3 Gene

Gene Families for TUSC3 Gene

Protein Domains for TUSC3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 thioredoxin domain.
  • Belongs to the OST3/OST6 family.
  • Contains 1 thioredoxin domain.
  • Belongs to the OST3/OST6 family.
genes like me logo Genes that share domains with TUSC3: view

Function for TUSC3 Gene

Molecular function for TUSC3 Gene

UniProtKB/Swiss-Prot Function:
Magnesium transporter (PubMed:19717468). May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (PubMed:24685145).
genes like me logo Genes that share phenotypes with TUSC3: view

Human Phenotype Ontology for TUSC3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for TUSC3

miRNA for TUSC3 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TUSC3 Gene

Localization for TUSC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUSC3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TUSC3 Gene COMPARTMENTS Subcellular localization image for TUSC3 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
mitochondrion 4
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TUSC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,ISS --
GO:0005887 integral component of plasma membrane NAS 19717468
GO:0008250 oligosaccharyltransferase complex IDA 15835887
genes like me logo Genes that share ontologies with TUSC3: view

Pathways & Interactions for TUSC3 Gene

genes like me logo Genes that share pathways with TUSC3: view

Interacting Proteins for TUSC3 Gene

Selected Interacting proteins: Q13454-TUSC3_HUMAN for TUSC3 Gene via MINT I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TUSC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015693 magnesium ion transport IMP 19717468
GO:0043687 post-translational protein modification TAS --
GO:0045454 cell redox homeostasis IEA --
GO:0050890 cognition IMP 18455129
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with TUSC3: view

No data available for SIGNOR curated interactions for TUSC3 Gene

Drugs & Compounds for TUSC3 Gene

No Compound Related Data Available

Transcripts for TUSC3 Gene

Unigene Clusters for TUSC3 Gene

Tumor suppressor candidate 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC3 Gene

No ASD Table

Relevant External Links for TUSC3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUSC3 Gene

mRNA expression in normal human tissues for TUSC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUSC3 Gene

This gene is overexpressed in Nasal epithelium (43.5) and Placenta (10.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TUSC3 Gene

SOURCE GeneReport for Unigene cluster for TUSC3 Gene Hs.426324

mRNA Expression by UniProt/SwissProt for TUSC3 Gene

Tissue specificity: Expressed in most non-lymphoid cells and tissues examined, including prostate, lung, liver, colon, heart, kidney and pancreas.
genes like me logo Genes that share expression patterns with TUSC3: view

Protein tissue co-expression partners for TUSC3 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for TUSC3 Gene

Orthologs for TUSC3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUSC3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TUSC3 35
  • 92.22 (n)
  • 97.41 (a)
TUSC3 36
  • 97 (a)
(Canis familiaris)
Mammalia TUSC3 35
  • 93.53 (n)
  • 99.71 (a)
TUSC3 36
  • 99 (a)
(Mus musculus)
Mammalia Tusc3 35
  • 90.78 (n)
  • 98.56 (a)
Tusc3 16
Tusc3 36
  • 98 (a)
(Pan troglodytes)
Mammalia TUSC3 35
  • 99.62 (n)
  • 100 (a)
TUSC3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tusc3 35
  • 90.78 (n)
  • 98.27 (a)
(Monodelphis domestica)
Mammalia TUSC3 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TUSC3 36
  • 86 (a)
(Gallus gallus)
Aves TUSC3 35
  • 82 (n)
  • 94.57 (a)
TUSC3 36
  • 89 (a)
(Anolis carolinensis)
Reptilia TUSC3 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tusc3 35
  • 80.19 (n)
  • 93.29 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19274 35
(Danio rerio)
Actinopterygii Dr.12544 35
tusc3 35
  • 77.56 (n)
  • 93 (a)
TUSC3 (1 of 2) 36
  • 94 (a)
TUSC3 (2 of 2) 36
  • 95 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010010 35
  • 59.52 (n)
  • 59.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ostgamma 35
  • 60.13 (n)
  • 58.2 (a)
CG7830 36
  • 54 (a)
(Caenorhabditis elegans)
Secernentea ZK686.3 35
  • 54.5 (n)
  • 48.68 (a)
ZK686.3 36
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER413C 35
  • 42.42 (n)
  • 26.86 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C13904g 35
  • 45.48 (n)
  • 26.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OST3 35
  • 43.73 (n)
  • 23.93 (a)
OST3 36
  • 19 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03995 35
  • 44.82 (n)
  • 33.33 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAPB17E12.11 35
  • 42.6 (n)
  • 25.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10969 36
  • 50 (a)
Species with no ortholog for TUSC3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUSC3 Gene

Gene Tree for TUSC3 (if available)
Gene Tree for TUSC3 (if available)

Paralogs for TUSC3 Gene

Paralogs for TUSC3 Gene

(1) SIMAP similar genes for TUSC3 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TUSC3: view

Variants for TUSC3 Gene

Sequence variations from dbSNP and Humsavar for TUSC3 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs11545035 - 15,623,134(+) GCTCA(A/G)TCTTC reference, missense
VAR_069369 -
rs2042991 -- 15,590,988(-) ATCTG(A/G)CAAAA intron-variant
rs2042992 -- 15,590,772(-) actgc(C/T)tgagc intron-variant
rs2042993 -- 15,589,969(-) TCTAC(A/G)CCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUSC3 Gene

Variant ID Type Subtype PubMed ID
dgv2222e1 CNV Complex 17122850
nsv8298 CNV Gain+Loss 18304495
nsv818605 CNV Loss 17921354
dgv248e55 CNV Loss 17911159
nsv437055 CNV Loss 16327808
nsv890489 CNV Gain 21882294
dgv7727n71 CNV Loss 21882294
nsv517314 CNV Loss 19592680
nsv465554 CNV Loss 19166990
dgv7728n71 CNV Loss 21882294
dgv7729n71 CNV Loss 21882294
nsv6089 CNV Loss 18451855
esv272679 CNV Insertion 20981092
esv267814 CNV Insertion 20981092
esv1267406 CNV Insertion 17803354
esv28500 CNV Loss 19812545
nsv824551 CNV Loss 20364138
nsv433246 CNV Loss 18776910
esv2421337 CNV Deletion 20811451
nsv465555 CNV Loss 19166990
nsv818607 CNV Loss 17921354
dgv873n27 CNV Loss 19166990
nsv442472 CNV CNV 18776908
nsv514477 CNV Loss 21397061
esv2736657 CNV Deletion 23290073
nsv6090 CNV Insertion 18451855
esv2193216 CNV Deletion 18987734
esv4612 CNV Deletion 18987735
esv2656774 CNV Deletion 23128226
nsv890506 CNV Gain+Loss 21882294
nsv890507 CNV Loss 21882294
nsv510132 CNV Loss 20534489
esv2421867 CNV Deletion 20811451
dgv874n27 CNV Loss 19166990
dgv875n27 CNV Gain 19166990
nsv517114 CNV Gain+Loss 19592680
nsv818608 CNV Gain 17921354
nsv465564 CNV Loss 19166990
nsv890508 CNV Gain 21882294
nsv528536 CNV Loss 19592680
esv2736658 CNV Deletion 23290073
esv2736659 CNV Deletion 23290073
esv2736660 CNV Deletion 23290073
esv2672142 CNV Deletion 23128226
nsv510978 CNV Complex 20534489
dgv7730n71 CNV Loss 21882294
nsv507443 CNV Insertion 20534489
nsv520235 CNV Loss 19592680
esv270210 CNV Insertion 20981092
esv273636 CNV Insertion 20981092
nsv890511 CNV Loss 21882294
dgv7731n71 CNV Loss 21882294
nsv890514 CNV Loss 21882294
nsv890515 CNV Loss 21882294
nsv516746 CNV Gain 19592680
nsv522161 CNV Loss 19592680
nsv438042 CNV Loss 16468122
nsv528442 CNV Gain 19592680
nsv6091 CNV Loss 18451855

Variation tolerance for TUSC3 Gene

Residual Variation Intolerance Score: 7.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUSC3 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUSC3 Gene

Disorders for TUSC3 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TUSC3 Gene - From: OMIM, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
46xy sex reversal 5
  • 46,xy sex reversal 5
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
syndromic intellectual disability
  • foodborne botulism
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search TUSC3 in MalaCards View complete list of genes associated with diseases


  • Mental retardation, autosomal recessive 7 (MRT7) [MIM:611093]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269 PubMed:18452889, ECO:0000269 PubMed:18455129}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TUSC3

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TUSC3: view

No data available for Genatlas for TUSC3 Gene

Publications for TUSC3 Gene

  1. Structure and methylation-associated silencing of a gene within a homozygously deleted region of human chromosome band 8p22. (PMID: 8661104) Macgrogan D. … Bookstein R. (Genomics 1996) 2 3 4 67
  2. A defect in the TUSC3 gene is associated with autosomal recessive mental retardation. (PMID: 18452889) Garshasbi M. … Kuss A.W. (Am. J. Hum. Genet. 2008) 3 23
  3. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. (PMID: 10097140) Ishii H. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3
  4. Tumor suppressor candidate 3 (TUSC3) prevents the epithelial-to-mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells. (PMID: 25735931) KratochvA-lovA! K. … VaA8hara P. (Int. J. Cancer 2015) 3
  5. Association of TUSC3 gene polymorphisms with non-syndromic mental retardation based on nuclear families in the Qinba mountain area of China. (PMID: 25966277) Zhang M.J. … Gao X.C. (Genet. Mol. Res. 2015) 3

Products for TUSC3 Gene

Sources for TUSC3 Gene