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TUSC2 Gene

protein-coding   GIFtS: 50
GCID: GC03M050357

Tumor Suppressor Candidate 2

(Previous name: PDGFA associated protein 2)
(Previous symbol: PDAP2)
  See TUSC2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tumor Suppressor Candidate 21 2     Fusion 1 Protein2 3
PDAP21 2 3     C3orf112 3
FUS12 3 5     PDGFA-Associated Protein 22 3
PDGFA Associated Protein 21 2     PAP2
Fus-1 Protein2 3     LGCC3

External Ids:    HGNC: 170341   Entrez Gene: 113342   Ensembl: ENSG000001143837   OMIM: 6070525   UniProtKB: O758963   

Export aliases for TUSC2 gene to outside databases

Previous GC identifers: GC03M050321 GC03M050338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TUSC2 Gene:
This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently
available. (provided by RefSeq, Jul 2008)

GeneCards Summary for TUSC2 Gene:
TUSC2 (tumor suppressor candidate 2) is a protein-coding gene. Diseases associated with TUSC2 include lung cancer.

UniProtKB/Swiss-Prot: TUSC2_HUMAN, O75896
Function: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately
inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells

Gene Wiki entry for TUSC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUSC2 gene promoter:
         AP-1   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUSC2 promoter sequence
   Search Chromatin IP Primers for TUSC2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUSC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.3

TUSC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUSC2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M050357:  view genomic region     (about GC identifiers)

Start:
50,357,458 bp from pter      End:
50,365,682 bp from pter
Size:
8,225 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TUSC2_HUMAN, O75896 (See protein sequence)
Recommended Name: Tumor suppressor candidate 2  
Size: 110 amino acids; 12074 Da
Secondary accessions: B2R4Y9

Explore the universe of human proteins at neXtProt for TUSC2: NX_O75896

Explore proteomics data for TUSC2 at MOPED

Post-translational modifications: 

  • Myristoylation is required for tumor suppressor activity1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TUSC2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_009206.1  
    ENSEMBL proteins: 
     ENSP00000232496   ENSP00000399199   ENSP00000409488   ENSP00000394844  

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    antibodies-online proteins for TUSC2 (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: O75896

    UniProtKB/Swiss-Prot: TUSC2_HUMAN, O75896
    Similarity: Belongs to the TUSC2 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TUSC2_HUMAN, O75896
    Function: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately
    inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells

    Phenotypes:
         1 GenomeRNAi human phenotype for TUSC2:

     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tusc2):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  renal/urinary system  tumorigenesis 

    Find genes that share phenotypes with TUSC2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tusc2tm1Avi for TUSC2

       genOway: Develop your customized and physiologically relevant rodent model for TUSC2

    miRNA
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    miRTarBase miRNAs that target TUSC2:
    hsa-mir-132-3p (MIRT021769), hsa-mir-197-3p (MIRT004412), hsa-mir-615-3p (MIRT040404), hsa-mir-378a-5p (MIRT003753), hsa-mir-93-5p (MIRT004410), hsa-mir-98-5p (MIRT004411), hsa-mir-373-3p (MIRT002528), hsa-mir-378a-3p (MIRT004423), hsa-let-7a-5p (MIRT004959), hsa-mir-92a-3p (MIRT049184), hsa-mir-7-5p (MIRT025636)

    Block miRNA regulation of human, mouse, rat TUSC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUSC2 (see all 57):
    hsa-miR-302d hsa-miR-520e hsa-let-7d hsa-miR-106a hsa-miR-486-3p hsa-let-7g hsa-miR-372 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidTUSC2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion2
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with TUSC2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUSC2
    Interactions:

        GeneGlobe Interaction Network for TUSC2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    Selected Interacting proteins for TUSC2 (O758961, 3 ENSP000002324964) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA4LO957571, 3, ENSP000002964644EBI-1052725,EBI-358652 I2D: score=2 STRING: ENSP00000296464
    LRBAP508511, 3, ENSP000003496294EBI-1052725,EBI-1052167 I2D: score=2 STRING: ENSP00000349629
    EBLN2Q6P2I71, 3EBI-1052725,EBI-1047027 I2D: score=2 
    GK006Q6P2I71, 3EBI-1052725,EBI-1047027 I2D: score=2 
    SGOL2Q562F61, 3, ENSP000003504474EBI-1052725,EBI-989213 I2D: score=2 STRING: ENSP00000350447
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001779natural killer cell differentiation IEA--
    GO:0006954inflammatory response IEA--
    GO:0007049cell cycle IEA--
    GO:0007267cell-cell signaling TAS8780057
    GO:0008283cell proliferation TAS8780057

    Find genes that share ontologies with TUSC2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TUSC2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUSC2 gene: 
    NM_007275.1  

    Unigene Cluster for TUSC2:

    Tumor suppressor candidate 2
    Hs.517981  [show with all ESTs]
    Unigene Representative Sequence: AF055479
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462137 ENST00000232496(uc003czy.1 uc003czz.1) ENST00000454201
    ENST00000421918 ENST00000463304 ENST00000417867
    miRNA
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    Block miRNA regulation of human, mouse, rat TUSC2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUSC2 (see all 57):
    hsa-miR-302d hsa-miR-520e hsa-let-7d hsa-miR-106a hsa-miR-486-3p hsa-let-7g hsa-miR-372 hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidTUSC2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TUSC2 (NM_007275)
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    OriGene qPCR primer pairs and template standards for TUSC2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUSC2
      QuantiTect SYBR Green Assays in human, mouse, rat TUSC2
      QuantiFast Probe-based Assays in human, mouse, rat TUSC2

    Additional mRNA sequence: 

    AF055479.1 AK124058.1 AK311998.1 BC023976.2 

    8 DOTS entries:

    DT.95341003  DT.454879  DT.100817374  DT.92067654  DT.120897431  DT.40197581  DT.95341008  DT.100770554 

    Selected AceView cDNA sequences (see all 274):

    BM695081 AA913793 BE500944 AI498136 BM511928 BM983492 AI143505 AW271785 
    CA309900 BM914699 AA314519 N24898 BI488886 CR611235 AW139362 BI522762 
    AI393302 AA621105 Z42475 BF037105 BQ278879 AA494104 AA317845 BM921777 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TUSC2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:                                -                                       
    SP2:                                                                        
    SP3:                          -     -                                       
    SP4:                          -     -                 -                     
    SP5:                                                                        


    ECgene alternative splicing isoforms for TUSC2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUSC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGATGTCGT
    TUSC2 Expression
    About this image

    TUSC2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUSC2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517981

    UniProtKB/Swiss-Prot: TUSC2_HUMAN, O75896
    Tissue specificity: Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and
    liver, lowest levels in placenta

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TUSC2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tusc21 , 5 tumor suppressor candidate 21, 5 88.79(n)1
    92.73(a)1
      9 (58.12 cM)5
    803851  NM_019742.41  NP_062716.11 
     1075632555 
    chicken
    (Gallus gallus)
    Aves TUSC21 tumor suppressor candidate 2 83.89(n)
    88.33(a)
      415910  XM_414259.4  XP_414259.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUSC26
    tumor suppressor candidate 2
    78(a)
    1 ↔ 1
    2(149984340-149993090)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC688092 hypothetical protein MGC68809 78.16(n)    BC060441.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.155282 Transcribed sequence with weak similarity to protein more 77.78(n)    BM316632.1 


    ENSEMBL Gene Tree for TUSC2 (if available)
    TreeFam Gene Tree for TUSC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUSC2 (see all 106)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447706611,2
    --50362283(+) TTGAAC/TCCAGG 1 -- ds50010--------
    rs115496731,2
    C,F,H--50362371(+) AAATTG/AAACAA 1 -- ut319Minor allele frequency- A:0.05NS NA 1080
    rs1478219221,2
    C--50362448(+) CAGAGA/CTTGCA 1 -- ut310--------
    rs561593011,2
    C--50362466(+) TAAAAA/GAAAAG 1 -- ut310--------
    rs1413702231,2
    --50362535(+) TTCACA/GTTATA 1 -- ut310--------
    rs1452850691,2
    C--50362756(+) AGCCAC/TGGAGA 1 -- ut310--------
    rs1827057471,2
    --50362935(+) CCCACC/TCAGTC 1 -- ut310--------
    rs729329831,2
    C,F--50363023(+) GGCTGG/ACACTG 1 -- ut314Minor allele frequency- A:0.19WA CSA 124
    rs1451144471,2
    C--50363071(+) GCAAAC/TGGCTG 1 -- ut310--------
    rs793580081,2
    C,F--50363082(+) AAATGC/TTCTGA 1 -- ut311Minor allele frequency- T:0.01WA 118

    HapMap Linkage Disequilibrium report for TUSC2 (50357458 - 50365682 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TUSC2 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5132n71CNV Loss21882294
    nsv523662CNV Loss19592680
    dgv5133n71CNV Loss21882294
    nsv876770CNV Loss21882294
    nsv3813CNV Loss18451855
    dgv5131n71CNV Loss21882294
    nsv876769CNV Loss21882294
    nsv834692CNV Loss17160897
    nsv470561CNV Loss18288195
    nsv834693CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUSC2
    DNA2.0 Custom Variant and Variant Library Synthesis for TUSC2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607052    OMIM disorders: --

    1 disease for TUSC2:    
    About MalaCards
    lung cancer


    Find genes that share disorders with TUSC2           About GenesLikeMe

    7 Novoseek inferred disease relationships for TUSC2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung tumor 58.2 3 15486560 (1), 15126327 (1), 18172250 (1)
    nsclc 57.5 11 17234782 (4), 17828283 (3), 15486560 (1), 11593436 (1)
    cancer lung 57.5 24 17828283 (3), 17234782 (3), 15486560 (2), 18172250 (2) (see all 8)
    lung metastases 54.3 1 15126327 (1)
    cancer 20.3 4 15126327 (1), 18172250 (1), 11593436 (1), 18379348 (1)
    tumors 18.8 31 17234782 (6), 17828283 (5), 11980673 (3), 18379348 (3) (see all 7)
    breast cancer 17.7 2 11593436 (1), 11980673 (1)


    Export disorders for TUSC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUSC2 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TUSC2)
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    1. Overexpression of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth inhibition of lung cancer cells. (PubMed id 11593436)1, 2, 3, 9 Kondo M....Minna J.D. (Oncogene 2001)
    2. Myristoylation of the fus1 protein is required for tumor suppression in human lung cancer cells. (PubMed id 15126327)1, 2, 9 Uno F.... Ji L. (Cancer Res. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Characterization of a novel platelet-derived growth factor-associated protein. (PubMed id 8780057)1, 3 Fischer W.H. and Schubert D. (J. Neurochem. 1996)
    6. Loss and reduction of FUS1 protein expression is a frequent phenomenon in the pathogenesis of lung cancer. (PubMed id 18172250)1, 9 Prudkin L....Wistuba I.I. (Clin. Cancer Res. 2008)
    7. Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomas. (PubMed id 21273575)1 Li G....Endo N. (Anticancer Res. 2011)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Regulation of tumor suppressor gene FUS1 expression by the untranslated regions of mRNA in human lung cancer cells. (PubMed id 21645495)1 Lin J....Ji L. (Biochem. Biophys. Res. Commun. 2011)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11334 HGNC: 17034 AceView: TUSC2 Ensembl:ENSG00000114383 euGenes: HUgn11334
    ECgene: TUSC2 H-InvDB: TUSC2

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TUSC2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TUSC2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for TUSC2 gene:
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