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Aliases for TUSC1 Gene

Aliases for TUSC1 Gene

  • Tumor Suppressor Candidate 1 2 3 5
  • TSG-9 3 4
  • TSG9 3 4

External Ids for TUSC1 Gene

Previous GeneCards Identifiers for TUSC1 Gene

  • GC09U900702

Summaries for TUSC1 Gene

Entrez Gene Summary for TUSC1 Gene

  • This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUSC1 Gene

TUSC1 (Tumor Suppressor Candidate 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUSC1 Gene

Genomics for TUSC1 Gene

Regulatory Elements for TUSC1 Gene

Promoters for TUSC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TUSC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUSC1 Gene

Chromosome:
9
Start:
25,676,389 bp from pter
End:
25,678,858 bp from pter
Size:
2,470 bases
Orientation:
Minus strand

Genomic View for TUSC1 Gene

Genes around TUSC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUSC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUSC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC1 Gene

Proteins for TUSC1 Gene

  • Protein details for TUSC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAM9-TUSC1_HUMAN
    Recommended name:
    Tumor suppressor candidate gene 1 protein
    Protein Accession:
    Q2TAM9
    Secondary Accessions:
    • A0PJ78
    • Q67GI3
    • Q86SS1
    • Q8TAH8

    Protein attributes for TUSC1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23390 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO38227.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TUSC1 Gene

Proteomics data for TUSC1 Gene at MOPED

Post-translational modifications for TUSC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUSC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUSC1 Gene

Domains & Families for TUSC1 Gene

Protein Domains for TUSC1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TUSC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TUSC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TUSC1 Gene

Function for TUSC1 Gene

genes like me logo Genes that share phenotypes with TUSC1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUSC1 Gene

Localization for TUSC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUSC1 Gene COMPARTMENTS Subcellular localization image for TUSC1 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TUSC1 Gene

Pathways & Interactions for TUSC1 Gene

SuperPathways for TUSC1 Gene

No Data Available

Interacting Proteins for TUSC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000350716%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000350716 for TUSC1 Gene via STRING

Symbol External ID(s) Details
ELAVL1

Gene Ontology (GO) - Biological Process for TUSC1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TUSC1 Gene

Drugs & Compounds for TUSC1 Gene

No Compound Related Data Available

Transcripts for TUSC1 Gene

mRNA/cDNA for TUSC1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUSC1 Gene

Tumor suppressor candidate 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC1 Gene

No ASD Table

Relevant External Links for TUSC1 Gene

GeneLoc Exon Structure for
TUSC1
ECgene alternative splicing isoforms for
TUSC1

Expression for TUSC1 Gene

mRNA expression in normal human tissues for TUSC1 Gene

Protein differential expression in normal tissues from HIPED for TUSC1 Gene

This gene is overexpressed in Liver, secretome (37.9), Neutrophil (24.8), and Adipocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TUSC1 Gene



SOURCE GeneReport for Unigene cluster for TUSC1 Gene Hs.26268

mRNA Expression by UniProt/SwissProt for TUSC1 Gene

Q2TAM9-TUSC1_HUMAN
Tissue specificity: Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.
genes like me logo Genes that share expression patterns with TUSC1: view

Protein tissue co-expression partners for TUSC1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TUSC1 Gene

Orthologs for TUSC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TUSC1 35
  • 85.14 (n)
  • 85.14 (a)
TUSC1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tusc1 35
  • 76.91 (n)
  • 72.2 (a)
Tusc1 16
Tusc1 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUSC1 35
  • 97.8 (n)
  • 96.23 (a)
TUSC1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUSC1 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUSC1 36
  • 43 (a)
OneToOne
Species with no ortholog for TUSC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TUSC1 Gene

ENSEMBL:
Gene Tree for TUSC1 (if available)
TreeFam:
Gene Tree for TUSC1 (if available)

Paralogs for TUSC1 Gene

No data available for Paralogs for TUSC1 Gene

Variants for TUSC1 Gene

Sequence variations from dbSNP and Humsavar for TUSC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs34498078 - 25,677,955(+) CCCGT(C/T)GCCGC reference, missense
rs12348 -- 25,677,217(+) AAGAA(C/T)AGCTG utr-variant-3-prime
rs1128953 -- 25,677,351(-) TCATA(G/T)TCCCT utr-variant-3-prime
rs1128957 -- 25,677,259(-) TAGTT(C/G)GTTGA utr-variant-3-prime
rs4592123 -- 25,676,586(+) CGAAG(A/C)GCAAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TUSC1 Gene

Variant ID Type Subtype PubMed ID
nsv831530 CNV Gain 17160897
dgv8132n71 CNV Gain 21882294
nsv892836 CNV Loss 21882294
nsv824893 CNV Gain 20364138

Variation tolerance for TUSC1 Gene

Gene Damage Index Score: 4.62; 65.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUSC1 Gene

HapMap Linkage Disequilibrium report
TUSC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUSC1 Gene

Disorders for TUSC1 Gene

Relevant External Links for TUSC1

Genetic Association Database (GAD)
TUSC1
Human Genome Epidemiology (HuGE) Navigator
TUSC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUSC1

No disorders were found for TUSC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUSC1 Gene

Publications for TUSC1 Gene

  1. Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer. (PMID: 15208665) Shan Z. … Wiest J.S. (Oncogene 2004) 2 3 4 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer. (PMID: 24700496) Kanda M. … Kodera Y. (J Surg Oncol 2014) 3
  4. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. (PMID: 25085501) Bunyavanich S. … Weiss S.T. (BMC Med Genomics 2014) 3
  5. A genome-wide association study of sleep habits and insomnia. (PMID: 23728906) Byrne E.M. … Wray N.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013) 3

Products for TUSC1 Gene

Sources for TUSC1 Gene

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