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Aliases for TUSC1 Gene

Aliases for TUSC1 Gene

  • Tumor Suppressor Candidate 1 2 3
  • TSG9 3 4 6
  • TSG-9 3 4
  • Tumor Suppressor Candidate Gene 1 Protein 3

External Ids for TUSC1 Gene

Previous GeneCards Identifiers for TUSC1 Gene

  • GC09U900702

Summaries for TUSC1 Gene

Entrez Gene Summary for TUSC1 Gene

  • This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUSC1 Gene

TUSC1 (Tumor Suppressor Candidate 1) is a Protein Coding gene. Diseases associated with TUSC1 include lung cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUSC1 Gene

Genomics for TUSC1 Gene

Regulatory Elements for TUSC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUSC1 Gene

25,676,389 bp from pter
25,678,858 bp from pter
2,470 bases
Minus strand

Genomic View for TUSC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUSC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC1 Gene

Proteins for TUSC1 Gene

  • Protein details for TUSC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor suppressor candidate gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • A0PJ78
    • Q67GI3
    • Q86SS1
    • Q8TAH8

    Protein attributes for TUSC1 Gene

    212 amino acids
    Molecular mass:
    23390 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO38227.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TUSC1 Gene

Proteomics data for TUSC1 Gene at MOPED

Post-translational modifications for TUSC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUSC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUSC1 Gene

Domains for TUSC1 Gene

Protein Domains for TUSC1 Gene


Suggested Antigen Peptide Sequences for TUSC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TUSC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TUSC1 Gene

Function for TUSC1 Gene

Animal Model Products

miRNA for TUSC1 Gene

miRTarBase miRNAs that target TUSC1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUSC1 Gene

Localization for TUSC1 Gene

Subcellular locations from

Jensen Localization Image for TUSC1 Gene COMPARTMENTS Subcellular localization image for TUSC1 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TUSC1 Gene

Pathways for TUSC1 Gene

SuperPathways for TUSC1 Gene

No Data Available

Interacting Proteins for TUSC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350716 for TUSC1 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TUSC1 Gene


No data available for Pathways by source for TUSC1 Gene

Transcripts for TUSC1 Gene

mRNA/cDNA for TUSC1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUSC1 Gene

Tumor suppressor candidate 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC1 Gene

No ASD Table

Relevant External Links for TUSC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUSC1 Gene

mRNA expression in normal human tissues for TUSC1 Gene

Protein differential expression in normal tissues for TUSC1 Gene

This gene is overexpressed in Liver, secretome (37.9), Neutrophil (24.8), and Adipocyte (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TUSC1 Gene

SOURCE GeneReport for Unigene cluster for TUSC1 Gene Hs.26268

mRNA Expression by UniProt/SwissProt for TUSC1 Gene

Tissue specificity: Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.
genes like me logo Genes that share expressions with TUSC1: view

Expression partners for TUSC1 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TUSC1 Gene

Orthologs for TUSC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TUSC1 35
  • 85.14 (n)
  • 85.14 (a)
TUSC1 36
  • 79 (a)
(Mus musculus)
Mammalia Tusc1 35
  • 76.91 (n)
  • 72.2 (a)
Tusc1 16
Tusc1 36
  • 73 (a)
(Pan troglodytes)
Mammalia TUSC1 35
  • 97.8 (n)
  • 96.23 (a)
TUSC1 36
  • 96 (a)
(Monodelphis domestica)
Mammalia TUSC1 36
  • 62 (a)
(Gallus gallus)
Aves TUSC1 36
  • 43 (a)
Species with no ortholog for TUSC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TUSC1 Gene

Gene Tree for TUSC1 (if available)
Gene Tree for TUSC1 (if available)

Paralogs for TUSC1 Gene

No data available for Paralogs for TUSC1 Gene

Variants for TUSC1 Gene

Sequence variations from dbSNP and Humsavar for TUSC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12348 -- 25,677,217(+) AAGAA(C/T)AGCTG utr-variant-3-prime
rs1128953 -- 25,677,351(-) TCATA(G/T)TCCCT utr-variant-3-prime
rs1128957 -- 25,677,259(-) TAGTT(C/G)GTTGA utr-variant-3-prime
rs4592123 -- 25,676,586(+) CGAAG(A/C)GCAAT utr-variant-3-prime
rs5897160 -- 25,676,183(+) CGTGA(-/C)CCCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TUSC1 Gene

Variant ID Type Subtype PubMed ID
nsv831530 CNV Gain 17160897
dgv8132n71 CNV Gain 21882294
nsv892836 CNV Loss 21882294
nsv824893 CNV Gain 20364138

Relevant External Links for TUSC1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUSC1 Gene

Disorders for TUSC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TUSC1 Gene in MalaCards »

(1) Disease for TUSC1 Gene

Relevant External Links for TUSC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TUSC1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TUSC1 Gene

Publications for TUSC1 Gene

  1. Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer. (PMID: 15208665) Shan Z. … Wiest J.S. (Oncogene 2004) 2 3 4 23
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 48
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3
  4. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox C.S. … Borecki I.B. (PLoS Genet. 2012) 3
  5. A genome-wide association study of sleep habits and insomnia. (PMID: 23728906) Byrne E.M. … Wray N.R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2013) 3

Products for TUSC1 Gene

Sources for TUSC1 Gene

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