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Aliases for TUSC1 Gene

Aliases for TUSC1 Gene

  • Tumor Suppressor Candidate 1 2 3 5
  • TSG-9 3 4
  • TSG9 3 4
  • Tumor Suppressor Candidate Gene 1 Protein 3

External Ids for TUSC1 Gene

Previous GeneCards Identifiers for TUSC1 Gene

  • GC09U900702

Summaries for TUSC1 Gene

Entrez Gene Summary for TUSC1 Gene

  • This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TUSC1 Gene

TUSC1 (Tumor Suppressor Candidate 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUSC1 Gene

Genomics for TUSC1 Gene

Regulatory Elements for TUSC1 Gene

Enhancers for TUSC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F025676 0.6 ENCODE 12.9 +0.8 820 2.4 TBP SREBF2 ZNF76 ZBTB40 RAD21 GLIS2 ELK1 RCOR1 ELK4 SP3 TUSC1 PIR46793
GH09F025396 0.5 ENCODE 5.7 +281.8 281808 1.9 POU5F1 TUSC1 GC09P025403 GC09P025386
GH09F025518 0.5 ENCODE 4.5 +159.5 159521 1.8 GATA3 CTBP1 DPF2 TUSC1 GC09M025400 LOC105375996
GH09F025513 0.5 ENCODE 4.5 +165.1 165111 1.0 TUSC1 GC09M025400 GC09P025477
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TUSC1 on UCSC Golden Path with GeneCards custom track

Promoters for TUSC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001301671 1057 2400 TBP SREBF2 ZNF76 ZBTB40 RAD21 GLIS2 ELK1 RCOR1 DEK ELK4

Genomic Location for TUSC1 Gene

25,676,389 bp from pter
25,678,858 bp from pter
2,470 bases
Minus strand

Genomic View for TUSC1 Gene

Genes around TUSC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUSC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUSC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUSC1 Gene

Proteins for TUSC1 Gene

  • Protein details for TUSC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor suppressor candidate gene 1 protein
    Protein Accession:
    Secondary Accessions:
    • A0PJ78
    • Q67GI3
    • Q86SS1
    • Q8TAH8

    Protein attributes for TUSC1 Gene

    212 amino acids
    Molecular mass:
    23390 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAO38227.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TUSC1 Gene

Post-translational modifications for TUSC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUSC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUSC1 Gene

Domains & Families for TUSC1 Gene

Protein Domains for TUSC1 Gene


Suggested Antigen Peptide Sequences for TUSC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TUSC1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TUSC1 Gene

Function for TUSC1 Gene

genes like me logo Genes that share phenotypes with TUSC1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUSC1 Gene

Localization for TUSC1 Gene

Subcellular locations from

Jensen Localization Image for TUSC1 Gene COMPARTMENTS Subcellular localization image for TUSC1 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TUSC1 Gene

Pathways & Interactions for TUSC1 Gene

SuperPathways for TUSC1 Gene

No Data Available

Interacting Proteins for TUSC1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000350716 Q2TAM9-TUSC1_HUMAN for TUSC1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TUSC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TUSC1 Gene

Transcripts for TUSC1 Gene

mRNA/cDNA for TUSC1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUSC1 Gene

Tumor suppressor candidate 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUSC1 Gene

No ASD Table

Relevant External Links for TUSC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUSC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUSC1 Gene

Protein differential expression in normal tissues from HIPED for TUSC1 Gene

This gene is overexpressed in Liver, secretome (37.9), Neutrophil (24.8), and Adipocyte (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TUSC1 Gene

Protein tissue co-expression partners for TUSC1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TUSC1 Gene:


SOURCE GeneReport for Unigene cluster for TUSC1 Gene:


mRNA Expression by UniProt/SwissProt for TUSC1 Gene:

Tissue specificity: Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle, colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of the 9p region, while it is down-regulated in 3 other tumor cell lines.
genes like me logo Genes that share expression patterns with TUSC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TUSC1 Gene

Orthologs for TUSC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUSC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TUSC1 34 35
  • 97.8 (n)
(Bos Taurus)
Mammalia TUSC1 34 35
  • 85.14 (n)
(Mus musculus)
Mammalia Tusc1 34 16 35
  • 76.91 (n)
(Monodelphis domestica)
Mammalia TUSC1 35
  • 62 (a)
(Gallus gallus)
Aves TUSC1 35
  • 43 (a)
Species where no ortholog for TUSC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TUSC1 Gene

Gene Tree for TUSC1 (if available)
Gene Tree for TUSC1 (if available)

Paralogs for TUSC1 Gene

No data available for Paralogs for TUSC1 Gene

Variants for TUSC1 Gene

Sequence variations from dbSNP and Humsavar for TUSC1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10699610 -- 25,680,565(+) TACTT(-/AAAAG)AAAAC upstream-variant-2KB
rs10738727 -- 25,679,026(+) CAAAA(C/G)CTATG upstream-variant-2KB
rs10738728 -- 25,679,139(+) GGTCT(C/T)AACCT upstream-variant-2KB
rs10738729 -- 25,679,143(+) TCAAC(C/T)TACAT upstream-variant-2KB
rs10812298 -- 25,676,811(+) TTTAG(A/C)TTATT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TUSC1 Gene

Variant ID Type Subtype PubMed ID
esv3573179 CNV loss 25503493
nsv613889 CNV gain 21841781
nsv613912 CNV loss 21841781
nsv824893 CNV gain 20364138
nsv831530 CNV gain 17160897

Variation tolerance for TUSC1 Gene

Gene Damage Index Score: 4.62; 65.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUSC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUSC1 Gene

Disorders for TUSC1 Gene

Relevant External Links for TUSC1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TUSC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUSC1 Gene

Publications for TUSC1 Gene

  1. Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer. (PMID: 15208665) Shan Z. … Wiest J.S. (Oncogene 2004) 2 3 4 22 64
  2. Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations. (PMID: 20574843) Yang X.R. … Goldstein A.M. (Fam. Cancer 2010) 3 46 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Clinical significance of expression and epigenetic profiling of TUSC1 in gastric cancer. (PMID: 24700496) Kanda M. … Kodera Y. (J Surg Oncol 2014) 3 64
  5. Integrated genome-wide association, coexpression network, and expression single nucleotide polymorphism analysis identifies novel pathway in allergic rhinitis. (PMID: 25085501) Bunyavanich S. … Weiss S.T. (BMC Med Genomics 2014) 3 64

Products for TUSC1 Gene

Sources for TUSC1 Gene

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