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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUSC1 Gene

protein-coding GIFtS: 39
GCID: GC09M025668

tumor suppressor candidate 1

Explore 6 diseases affiliated with
TUSC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tumor Suppressor Candidate 1¹ ²
TSG-9¹ ² ³
TSG9² ³ ⁵
Tumor Suppressor Candidate Gene 1 Protein²

External Ids:	HGNC: 31010¹	Entrez Gene: 286319²	Ensembl: ENSG00000198680⁷	OMIM: 610529⁵	UniProtKB: Q2TAM9³

Export aliases for TUSC1 gene to outside databases

Previous GC identifer: GC09U900702

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUSC1:

This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis.

It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines,

suggesting that it may play a role in lung tumorigenesis. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TUSC1 gene promoter:
AML1a AP-2gamma CREB Nkx6-1 NRF-2 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TUSC1 promoter sequence

Search SABiosciences Chromatin IP Primers for TUSC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUSC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.2 Ensembl cytogenetic band: 9p21.2 HGNC cytogenetic band: 9p21.2

TUSC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUSC1 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M025668: view genomic region (about GC identifiers)

Start:	25,676,387 bp from pter	End:	25,678,856 bp from pter
Size:	2,470 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TUSC1_HUMAN, Q2TAM9 (See protein sequence)

Recommended Name: Tumor suppressor candidate gene 1 protein

Size: 212 amino acids; 23390 Da

Caution: It is uncertain whether Met-1 or Met-4 is the initiator

Sequence caution: Sequence=AAO38227.2; Type=Erroneous initiation;

Secondary accessions: A0PJ78 Q67GI3 Q86SS1 Q8TAH8

Explore the universe of human proteins at neXtProt for TUSC1: NX_Q2TAM9

TUSC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001004125.1

ENSEMBL proteins:

ENSP00000350716

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q2TAM9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TUSC1

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TUSC1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TUSC1 (ENSP00000350716⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TUSC1
Search CenterWatch for drugs/clinical trials and news about TUSC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUSC1 gene:

NM_001004125.2

Unigene Cluster for TUSC1:

Tumor suppressor candidate 1

Hs.26268 [show with all ESTs]

Unigene Representative Sequence: NM_001004125

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000358022(uc003zpx.3)

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		hsa-miR-3671 hsa-miR-3163 hsa-miR-607 hsa-miR-588 hsa-miR-7-2* hsa-miR-409-3p hsa-miR-501-3p hsa-miR-340

		SwitchGear 3'UTR luciferase reporter plasmid: TUSC1 3' UTR sequence

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Additional cDNA sequence:

AY168647.2 BC017510.1 BC028316.1 BC036931.1 BC046919.1 BC110824.1

2 DOTS entries:

DT.311858 DT.100746746

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUSC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TUSC1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 6 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor E69 (Embryonic Progenitor Cell)

Fetal cardiomyocytes (20 weeks) (Primary Cell)

Heart, Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TUSC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUSC1

SOURCE GeneReport for Unigene cluster: Hs.26268

UniProtKB/Swiss-Prot: TUSC1_HUMAN, Q2TAM9

Tissue specificity: Widely expressed at low level. Expressed at higher level in testis, weakly expressed in muscle,

colon, lung and spleen. Not detected in 3 non small cell lung carcinoma (NSCLC) cell lines with homozygous deletion of

the 9p region, while it is down-regulated in 3 other tumor cell lines

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TUSC1 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tusc1^{1 , 5}	tumor suppressor candidate 1^{1, 5}	79.19(n)¹ 74.63(a)¹		4 (43.25 cM)⁵ 69136¹ NM_026954.1¹ NP_081230.1¹ 93334138⁵
chicken (Gallus gallus)	Aves	TUSC1⁶	Uncharacterized protein	46(a)	1 ↔ 1	Z(66470968-66471519)

ENSEMBL Gene Tree for TUSC1 (if available)
TreeFam Gene Tree for TUSC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79920628^1,2	C	--	25628752(+)	`TAATAT/CTTAAT`	1	--	ut3¹		2		WA	120
rs79028168^1,2		--	25628770(+)	`GACTAC/TGCCAT`	1	--	ut3¹		0	--	--	--	--
rs73644561^1,2	C	--	25628882(+)	`GCACAG/ATGGTA`	1	--	ut3¹		1		WA	2
rs114948668^1,2	C,F	--	25629389(+)	`TGGGGG/ACAAAC`	1	--	ut3¹		1		WA	118
rs61483294^1,2	C,F	--	25630983(+)	`CTTCCG/ATGCAG`	1	--	ut5¹		3		WA	122
rs59975707^1,2	C	--	25631142(+)	`AAGTGG/CTTCAT`	1	--	ut5¹		1		WA	2
rs114410983^1,2	C,F	--	25631431(+)	`TCTGGG/AATCAA`	1	--	us2k¹		1		WA	118
rs73644562^1,2	C	--	25631714(+)	`TTGCTC/GAATTT`	1	--	us2k¹		2		WA	120
rs79872503^1,2	F	--	25631721(+)	`ATTTTT/ATTGTA`	1	--	us2k¹		1		NA	120
rs113512188^1,2	C	--	25632181(+)	`GAGAT-/GGGAGT`	1	--	us2k¹		1		CSA	2

HapMap Linkage Disequilibrium report for TUSC1 (25676387 - 25678856 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TUSC1: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TUSC1 for disorders           About GeneDecksing

OMIM gene information: 610529    OMIM disorders: --

6 diseases for TUSC1:    About MalaCards

lung cancer non-small cell lung carcinoma lung carcinoma alzheimer's disease

carcinoma melanoma

Human Genome Epidemiology (HuGE) Navigator: TUSC1 (1 document)

Export disorders for TUSC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TUSC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TUSC1)

Utopia: connect your pdf to the dynamic
world of online information

Identifying novel homozygous deletions by microsatellite analysis and characterization of tumor suppressor candidate 1 gene, TUSC1, on chromosome 9p in human lung cancer. (PubMed id 15208665)^{1, 2, 3, 9} Shan Z.... Wiest J.S. (2004)
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)¹ Fox C.S....Borecki I.B. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Associations of 9p21 variants with cutaneous malignan t melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with a nd without CDKN2A mutations. (PubMed id 20574843)¹ Yang X.R....Goldstein A.M. (2010)
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)¹ Furney S.J....Lovestone S. (2010)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)² Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 286319	HGNC: 31010	Ensembl:ENSG00000198680	euGenes: HUgn286319	ECgene: TUSC1
H-InvDB: TUSC1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TUSC1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TUSC1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TUSC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TUSC1 gene:
Search GeneIP for patents involving TUSC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUSC1

	GenScript Custom Purified and Recombinant Proteins Services for TUSC1		GenScript cDNA clones with any tag delivered in your preferred vector for TUSC1
	GenScript Custom Assay Services for TUSC1		GenScript Custom Superior Antibodies Services for TUSC1
	GenScript Custom overexpressing Cell Line Services for TUSC1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUSC1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TUSC1

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TUSC1 gene at Home site.

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TUSC1 Gene

tumor suppressor candidate 1

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TUSC1 Gene

tumor suppressor candidate 1

Aliasesfor TUSC1 gene

Summariesfor TUSC1 gene

Genomic Viewsfor TUSC1 gene

Proteinsfor TUSC1 gene

Protein Domains /Familiesfor TUSC1 gene

Functionfor TUSC1 gene

Pathways & Interactionsfor TUSC1 gene

Drugs & Compoundsfor TUSC1 gene

Transcriptsfor TUSC1 gene

Expression for TUSC1 gene

Orthologsfor TUSC1 gene

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Genomic Variantsfor TUSC1 gene

Disorders / Diseasesfor TUSC1 gene

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External Searches for TUSC1 gene

Genome Databases showing TUSC1 gene

Other Databases showing TUSC1 gene

Specialized Databases showing TUSC1 gene

Intellectual Propertyfor TUSC1 gene

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Aliases
for TUSC1 gene

Summaries
for TUSC1 gene

Genomic Views
for TUSC1 gene

Proteins
for TUSC1 gene

Protein Domains /
Families
for TUSC1 gene

Function
for TUSC1 gene

Pathways & Interactions
for TUSC1 gene

Drugs & Compounds
for TUSC1 gene

Transcripts
for TUSC1 gene

Expression
for TUSC1 gene

Orthologs
for TUSC1 gene

Paralogs
for TUSC1 gene

Genomic Variants
for TUSC1 gene

Disorders / Diseases
for TUSC1 gene

Publications
for TUSC1 gene

Intellectual Property
for TUSC1 gene

Products
for TUSC1 gene