TULP4 Gene
protein-coding GIFtS: 48
GCID: GC06P158733
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|
tubby like protein 4
| |
Aliases
for TULP4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tubby Like Protein 41 2 | | Tubby-Like Protein 42 3 | | TUSP1 2 3 | | Tubby Super-Family Protein2 | | KIAA13971 3 | | Tubby-Related Protein 42 | | Tubby Superfamily Protein2 3 | | TUBL43 |
Export aliases for TULP4 gene to outside databasesPrevious GC identifers: GC06P158567 GC06P158642 GC06P158704 GC06P158653 GC06P156205 |
Summaries
for TULP4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TULP4_HUMAN, Q9NRJ4Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Bysimilarity)
|
Genomic Views
for TULP4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TULP4 gene promoter:
ER-alpha AML1a MEF-2 MIF-1 Roaz MEF-2A POU2F1 POU2F1a COMP1 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TULP4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TULP4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25-q26 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25-q26TULP4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P158733: view genomic region
(about GC identifiers)
Start:
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158,733,692 bp from pter |
End:
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158,932,860 bp from pter |
Size:
|
199,169 bases |
Orientation:
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plus strand |
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Proteins
for TULP4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TULP4_HUMAN, Q9NRJ4 (See
protein sequence)Recommended Name: Tubby-related protein 4 Size: 1543 amino acids; 169000 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAF87975.1; Type=Frameshift; Positions=740, 744; Sequence=BAA92635.1; Type=Erroneousinitiation;
Secondary accessions: Q5T3M2 Q5T3M3 Q9HD22 Q9P2F0Alternative splicing: 2 isoforms: Q9NRJ4-1 Q9NRJ4-2 Explore the universe of human proteins at neXtProt for TULP4: NX_Q9NRJ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NRJ4
TULP4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001007467.1 NP_064630.2
ENSEMBL proteins: ENSP00000356064 ENSP00000356061
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
TULP4 for ontologies About GeneDecksing
TULP4 Antibody Products:
Assay Products for TULP4: |
Protein
Domains /
Families
for TULP4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TULP4 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9NRJ4ProtoNet protein and cluster: Q9NRJ4 1 Blocks protein family: IPB001496 SOCS protein
UniProtKB/Swiss-Prot: TULP4_HUMAN, Q9NRJ4Domain: The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3ubiquitin ligase complexes (By similarity)Similarity: Belongs to the TUB familySimilarity: Contains 1 SOCS box domainSimilarity: Contains 3 WD repeats |
Function
for TULP4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TULP4_HUMAN, Q9NRJ4Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitinligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (Bysimilarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TULP4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TULP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for TULP4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TULP4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | 11595174 |
TULP4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TULP4:
|
Pathways & Interactions
for TULP4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: TULP4_HUMAN, Q9NRJ4Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TULP4
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for TULP4 (Q9NRJ43 ENSP000003560644) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
TULP4 for ontologies About GeneDecksing
|
Drugs & Compounds
for TULP4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TULP4
Search CenterWatch for drugs/clinical trials and news about TULP4
|
Transcripts
for TULP4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TULP4 gene (2 alternative transcripts): NM_001007466.2 NM_020245.4 Unigene Cluster for TULP4: Tubby like protein 4 Hs.486993 [show with all ESTs]Unigene Representative Sequence: AF2199462 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367097(uc003qrf.3 uc003qrg.3) ENST00000367094(uc011efo.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TULP4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TULP4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TULP4 (NM_001007466) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TULP4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TULP4 |
Additional cDNA sequence: AB037818.1 AF087973.1 AF219946.2 AF288480.1 AK092091.1 AK304056.1 AK311671.1 BC152476.1 7 DOTS entries: DT.214505 DT.406280 DT.91861656 DT.121341511 DT.121341516 DT.91646846 DT.121341536 24/158 AceView cDNA sequences (see all 158): Z46080 BG502327 AI636156 BU431073 AW849321 N73107 AA846369 CK429824 AA063166 BU178735 AW769565 BF915064 BG504243 AI479209 BU501516 AA635969 CB153048 BF724629 AA063165 BX646714 BE465645 BI857972 AA931666 AI539775
GeneLoc Exon Structure
|
Expression
for TULP4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TULP4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAGACCTC
About this image
See TULP4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TULP4
SOURCE GeneReport for Unigene cluster: Hs.486993
UniProtKB/Swiss-Prot: TULP4_HUMAN, Q9NRJ4Tissue specificity: Expressed mainly in the brain, skeletal muscle, testis and kidney
SABiosciences Custom PCR Arrays for TULP4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TULP4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TULP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TULP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TULP4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP4 |
Orthologs
for TULP4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TULP4 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for TULP4 (if available)
TreeFam Gene Tree for TULP4 (if available) |
Paralogs
for TULP4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TULP4 gene
- TULP22 TUB2 TULP12 WDR352 TULP32
TULP4 for paralogs About GeneDecksing
|
Genomic Variants
for TULP4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TULP4 (158733692 - 158932860 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TULP4
3 CNVs: 99773 43284 2660
4 Indels: 40938 47032 41985 47033 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TULP4 |
|
Disorders
/ Diseases
for TULP4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TULP4 for disorders About GeneDecksing
3  diseases for TULP4: About MalaCardssensenbrenner syndrome craniosynostosis obesity
1 disease from the University of Copenhagen DISEASES database for TULP4:Sensenbrenner syndrome Human Genome Epidemiology (HuGE) Navigator: TULP4 (1 document)
Export disorders for TULP4 gene to outside databases
|
Publications
for TULP4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TULP4 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TULP4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. (PubMed id 11595174)1, 2, 3, 9 Li Q.-Z.... She J.-X. (2001)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for TULP4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TULP4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TULP4 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TULP4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TULP4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TULP4 gene:
Search GeneIP for patents involving TULP4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TULP4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TULP4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TULP4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TULP4 | | | OriGene Protein Over-expression Lysate for TULP4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TULP4 | | OriGene 3'-UTR Clone for TULP4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TULP4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TULP4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TULP4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TULP4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TULP4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TULP4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TULP4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TULP4 |
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 | | | TULP4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP4 |
|  |  |  | | | | Search ThermoFisher Antibodies for TULP4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TULP4 |
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