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Aliases for TULP4 Gene

Aliases for TULP4 Gene

  • Tubby Like Protein 4 2 3
  • Tubby Superfamily Protein 3 4
  • Tubby-Like Protein 4 3 4
  • TUSP 3 4
  • Tubby Super-Family Protein 3
  • Tubby-Related Protein 4 3
  • KIAA1397 4
  • TUBL4 4

External Ids for TULP4 Gene

Summaries for TULP4 Gene

GeneCards Summary for TULP4 Gene

TULP4 (Tubby Like Protein 4) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TUB.

UniProtKB/Swiss-Prot for TULP4 Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TULP4 Gene

Genomics for TULP4 Gene

Genomic Location for TULP4 Gene

Start:
158,232,236 bp from pter
End:
158,511,828 bp from pter
Size:
279,593 bases
Orientation:
Plus strand

Genomic View for TULP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TULP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TULP4 Gene

Regulatory Elements for TULP4 Gene

Proteins for TULP4 Gene

  • Protein details for TULP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRJ4-TULP4_HUMAN
    Recommended name:
    Tubby-related protein 4
    Protein Accession:
    Q9NRJ4
    Secondary Accessions:
    • Q5T3M2
    • Q5T3M3
    • Q9HD22
    • Q9P2F0

    Protein attributes for TULP4 Gene

    Size:
    1543 amino acids
    Molecular mass:
    169000 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF87975.1; Type=Frameshift; Positions=740, 744; Evidence={ECO:0000305}; Sequence=BAA92635.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TULP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TULP4 Gene

Proteomics data for TULP4 Gene at MOPED

Post-translational modifications for TULP4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TULP4 Gene

No data available for DME Specific Peptides for TULP4 Gene

Domains for TULP4 Gene

Gene Families for TULP4 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

TULP4_HUMAN
Domain:
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.:
    • Q9NRJ4
  • Contains 1 SOCS box domain.:
    • Q9NRJ4
Family:
  • Belongs to the TUB family.:
    • Q9NRJ4
Similarity:
  • Contains 7 WD repeats.:
    • Q9NRJ4
genes like me logo Genes that share domains with TULP4: view

Function for TULP4 Gene

Molecular function for TULP4 Gene

UniProtKB/Swiss-Prot Function: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for TULP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 11595174
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TULP4: view

Phenotypes for TULP4 Gene

GenomeRNAi human phenotypes for TULP4:
genes like me logo Genes that share phenotypes with TULP4: view

miRNA for TULP4 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TULP4 Gene

Localization for TULP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TULP4 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TULP4 Gene COMPARTMENTS Subcellular localization image for TULP4 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TULP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11595174
genes like me logo Genes that share ontologies with TULP4: view

Pathways for TULP4 Gene

SuperPathways for TULP4 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NRJ4-TULP4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TULP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 11595174
GO:0007584 response to nutrient --
GO:0016567 protein ubiquitination IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with TULP4: view

No data available for Pathways by source for TULP4 Gene

Transcripts for TULP4 Gene

Unigene Clusters for TULP4 Gene

Tubby like protein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TULP4 Gene

No ASD Table

Relevant External Links for TULP4 Gene

GeneLoc Exon Structure for
TULP4
ECgene alternative splicing isoforms for
TULP4

Expression for TULP4 Gene

mRNA expression in normal human tissues for TULP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TULP4 Gene

SOURCE GeneReport for Unigene cluster for TULP4 Gene Hs.486993

mRNA Expression by UniProt/SwissProt for TULP4 Gene

Q9NRJ4-TULP4_HUMAN
Tissue specificity: Expressed mainly in the brain, skeletal muscle, testis and kidney
genes like me logo Genes that share expressions with TULP4: view

Orthologs for TULP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TULP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TULP4 36
  • 99.45 (n)
  • 100 (a)
TULP4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TULP4 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TULP4 36
  • 88.05 (n)
  • 92.06 (a)
TULP4 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tulp4 36
  • 87.56 (n)
  • 94.49 (a)
Tulp4 16
Tulp4 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TULP4 37
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TULP4 37
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tulp4 36
  • 87.7 (n)
  • 94.1 (a)
chicken
(Gallus gallus)
Aves TULP4 36
  • 77.97 (n)
  • 84.82 (a)
TULP4 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TULP4 37
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18225 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12982 36
tulp4 36
  • 71.85 (n)
  • 81.84 (a)
zebrafish
(Danio rerio)
Actinopterygii tulp4a 36
  • 68.86 (n)
  • 73.76 (a)
tulp4a 37
  • 64 (a)
OneToMany
tulp4b 37
  • 66 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tusp 37
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tub-2 37
  • 35 (a)
OneToOne
Species with no ortholog for TULP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TULP4 Gene

ENSEMBL:
Gene Tree for TULP4 (if available)
TreeFam:
Gene Tree for TULP4 (if available)

Paralogs for TULP4 Gene

Paralogs for TULP4 Gene

genes like me logo Genes that share paralogs with TULP4: view

Variants for TULP4 Gene

Sequence variations from dbSNP and Humsavar for TULP4 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6880 -- 158,511,785(+) TGTAA(C/G)AGTTG utr-variant-3-prime
rs166391 -- 158,272,235(+) TTTCA(A/G)TTGGG intron-variant
rs173129 -- 158,431,859(-) CCTCA(C/T)GCCAA intron-variant
rs174491 -- 158,274,737(+) gcgcc(C/T)ctgca intron-variant
rs183797 -- 158,241,043(+) ccggg(C/T)agaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TULP4 Gene

Variant ID Type Subtype PubMed ID
nsv886797 CNV Gain 21882294
dgv2022e1 CNV Complex 17122850
essv20503 CNV CNV 17122850
esv2390619 CNV Deletion 18987734
esv2732994 CNV Deletion 23290073
nsv5560 CNV Insertion 18451855
esv4303 CNV Deletion 18987735
esv269627 CNV Insertion 20981092
esv2605411 CNV Deletion 19546169
esv2235507 CNV Deletion 18987734
esv5051 CNV Deletion 18987735
esv2732996 CNV Deletion 23290073
esv2658826 CNV Deletion 23128226
nsv5561 CNV Insertion 18451855
esv2116186 CNV Deletion 18987734
esv2732997 CNV Deletion 23290073
nsv349862 CNV Loss 16902084
dgv1074e201 CNV Deletion 23290073
dgv1072n67 CNV Gain 20364138

Relevant External Links for TULP4 Gene

HapMap Linkage Disequilibrium report
TULP4
Human Gene Mutation Database (HGMD)
TULP4

Disorders for TULP4 Gene

(1) University of Copenhagen DISEASES for TULP4 Gene

Relevant External Links for TULP4

Genetic Association Database (GAD)
TULP4
Human Genome Epidemiology (HuGE) Navigator
TULP4
genes like me logo Genes that share disorders with TULP4: view

No data available for UniProtKB/Swiss-Prot for TULP4 Gene

Publications for TULP4 Gene

  1. Molecular cloning and characterization of the mouse and human TUSP gene, a novel member of the tubby superfamily. (PMID: 11595174) Li Q.-Z. … She J.-X. (Gene 2001) 2 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  4. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for TULP4 Gene

Sources for TULP4 Gene

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