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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TULP3 Gene

protein-coding   GIFtS: 53
GCID: GC12P002987

tubby like protein 3
 Explore 2 diseases affiliated with
TULP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TULP3    

Aliases
for TULP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tubby Like Protein 31 2
TUBL31 2 3
Tubby-Like Protein 32 3
Tubby-Related Protein 32

External Ids:    HGNC: 124251   Entrez Gene: 72892   Ensembl: ENSG000000782467   OMIM: 6047305   UniProtKB: O753863   

Export aliases for TULP3 gene to outside databases

Previous GC identifers: GC12P002872 GC12P002870 GC12P003000


Summaries
for TULP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TULP3:
This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have
been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription
activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded
protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a
membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis,
for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and
function. Two transcript variants encoding distinct isoforms have been identified for this gene. (provided by RefSeq,
May 2009)

UniProtKB/Swiss-Prot: TULP3_HUMAN, O75386
Function: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with
the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of
PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide)
lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled
receptor trafficking. Not involved in ciliogenesis




Genomic Views
for TULP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009759.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TULP3 gene promoter:
         CREB   E2F   deltaCREB   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TULP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TULP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TULP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.33   HGNC cytogenetic band: 12p13

TULP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TULP3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P002987:  view genomic region     (about GC identifiers)

Start:
 2,986,389 bp from pter      End:
 3,050,306 bp from pter
Size:
 63,918 bases      Orientation:
 plus strand

Proteins
for TULP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TULP3_HUMAN, O75386 (See protein sequence)
Recommended Name: Tubby-related protein 3  
Size: 442 amino acids; 49642 Da
Subunit: Associates with the IFT complex A (IFT-A)
Subcellular location: Nucleus. Cell membrane. Cell projection, cilium. Cytoplasm (By similarity). Secreted (By
similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By
similarity). Translocates from the plasma membrane to the nucleus upon activation of guanine nucleotide-binding
protein G(q) subunit alpha
Secondary accessions: B3KNB7 D3DUQ4 Q8N5B0

Explore the universe of human proteins at neXtProt for TULP3: NX_O75386

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O75386

    • TULP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001153880.1  NP_003315.2  

    ENSEMBL proteins: 
     ENSP00000444110   ENSP00000442631   ENSP00000437899   ENSP00000441599   ENSP00000410051  
     ENSP00000380321   ENSP00000441319   ENSP00000440364   ENSP00000228245   ENSP00000443709  
     ENSP00000442818  

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    Novus Biologicals TULP3 Protein
    Novus Biologicals TULP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TULP3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0005634nucleus NAS11375483
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane NAS11375483
    GO:0005929cilium IEA--


    TULP3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TULP3

    Protein Domains /
    Families
    for TULP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TULP3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR025659 Tubby_C-like
     IPR018066 Tubby_C_CS
     IPR005398 Tubby_N
     IPR000007 Tubby_C

    Graphical View of Domain Structure for InterPro Entry O75386

    ProtoNet protein and cluster: O75386

    1 Blocks protein family: IPB000007 Tubby

    UniProtKB/Swiss-Prot: TULP3_HUMAN, O75386
    Similarity: Belongs to the TUB family


    Function
    for TULP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TULP3_HUMAN, O75386
    Function: Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with
    the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of
    PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide)
    lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled
    receptor trafficking. Not involved in ciliogenesis

         Genatlas biochemistry entry for TULP3:
    tubby-like protein 3,expressed in testis,ovary,thyroid,spinal cord,brain,and in retina,at a moderate level,only in the
    inner nuclear and ganglion cell layers

    miRNA
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    hsa-miR-548m hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: TULP3 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TULP3
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    Gene Editing
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    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TULP3 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for TULP3

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding NAS11375483


    TULP3 for ontologies           About GeneDecksing


    Animal Models:
         12 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Tulp3):
     cardiovascular system  cellular  craniofacial  embryogenesis  hematopoietic system 
     homeostasis/metabolism  integument  limbs/digits/tail  mortality/aging  nervous system 
     skeleton  vision/eye 

    TULP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TULP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TULP3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    4 Interacting proteins for TULP3 (O753861, 3 ENSP000002282454) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KBTBD7Q8WVZ93I2D: score=1 
    NEBP209291EBI-5357290,EBI-1049657
    UBCENSP000003448184STRING: ENSP00000344818
    vprP125201EBI-5357290,EBI-6164519
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development ----
    GO:0001843neural tube closure ----
    GO:0006355regulation of transcription, DNA-dependent NAS11375483
    GO:0007186G-protein coupled receptor signaling pathway NAS11375483
    GO:0007275multicellular organismal development IEA--


    TULP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TULP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TULP3
    Search CenterWatch for drugs/clinical trials and news about TULP3 

    Transcripts
    for TULP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TULP3 gene (2 alternative transcripts): 
    NM_001160408.1  NM_003324.4  

    Unigene Cluster for TULP3:

    Tubby like protein 3
    Hs.655333  [show with all ESTs]
    Unigene Representative Sequence: NM_003324
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540184 ENST00000544943 ENST00000538354 ENST00000545331 ENST00000448120(uc001qlj.2 uc010seh.1 uc010sei.1)
    ENST00000397132 ENST00000541678 ENST00000538704 ENST00000228245(uc009zec.1)
    ENST00000535226(uc010sef.1) ENST00000542730

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TULP3:
    hsa-miR-548m hsa-miR-4324
    SwitchGear 3'UTR luciferase reporter plasmid: TULP3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TULP3 (see all 4)
    OriGene shRNA RFP: TULP3
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TULP3
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TULP3 (NM_003324)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TULP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TULP3

    Additional cDNA sequence: 

    AF045583.1 AK024246.1 AK293285.1 AK307434.1 

    13 DOTS entries:

    DT.111226  DT.100848584  DT.95261985  DT.427274  DT.97842742  DT.121115192  DT.91880485  DT.121115291 
    DT.121115143  DT.91681990  DT.100782300  DT.121115302  DT.102827716 

    24/103 AceView cDNA sequences (see all 103):

    BM707825 AI014684 AU130490 AA936526 AI652257 NM_003324 BX338932 BU683007 
    AI918733 BM663855 AA669058 BM682836 AI028290 AW069863 BU677224 AI341445 
    BU733320 BM465141 AL556370 BM692638 CR598112 BQ018476 AI638667 CD514227 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TULP3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:                                                  -                                                               
    SP2:                                -                 -                                                               
    SP3:                    -     -     -     -     -     -     -     -                                                   
    SP4:                                                                                                                  
    SP5:                                                                                                        -         


    ECgene alternative splicing isoforms for TULP3

    Expression
    for TULP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TULP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGGAAGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TULP3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TULP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TULP3

    SOURCE GeneReport for Unigene cluster: Hs.655333

    UniProtKB/Swiss-Prot: TULP3_HUMAN, O75386
    Tissue specificity: Expressed at high levels in testis, ovaries, thyroid, and spinal chord

        SABiosciences Custom PCR Arrays for TULP3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP3

    Orthologs
    for TULP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TULP3 gene from 7/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TULP31 tubby like protein 3 68.86(n)
    66.36(a)    		   426085  XM_423762.3  XP_423762.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TULP36
    		 --
    		 59(a)
    		 1 ↔ 1
    		 5(80682153-80704456)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5662211 tubby-related protein 3-like 63.3(n)
    62.91(a)    		   566221  XM_689489.5  XP_694581.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Tulp3   -- 50(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea tub-13 Tub family protein tub-1 48(a)   II(8154693-8156859)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TLP116
    ATTLP96
    (see all 11)    		 tubby-like F-box protein 9
    (see all 11)    		 27(a)
    26(a)
    (see all 11)    		 many ↔ many
    many ↔ many
    (see all 11)    		 5(6228165-6230537)
    3(1936124-1938221)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 14)    		 OsFBT1 - F-box and tubby domain containing protein...
    OsFBT5 - F-box and tubby domain containing protein...
    (see all 14)    		 26(a)
    26(a)
    (see all 14)    		 many ↔ many
    many ↔ many
    (see all 14)    		 1(27715144-27720173)
    3(13163212-13168094)


    ENSEMBL Gene Tree for TULP3 (if available)
    TreeFam Gene Tree for TULP3 (if available) 

    Paralogs
    for TULP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TULP3 gene
    TULP22  TULP42  TUB2  TULP12  WDR352  
    3 SIMAP similar genes for TULP3 using alignment to 8 protein entries:     TULP3_HUMAN (see all proteins):
    TUB    TULP1    TULP2

    TULP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TULP3
    PGOHUM00000258716


    Genomic Variants
    for TULP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1080 NCBI SNPs in TULP3 are shown (see all 1080)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1822895521,2
    		--2998132(+) TTTTTA/TAGAGA 9 -- us2k1 ut31 nc-transcript-variant0--------
    rs787312011,2
    		C,F,--2998202(+) TTAACC/TACTAC 9 -- us2k1 ut31 nc-transcript-variant2Minor allele frequency- T:0.05NA EA 240
    rs1158007931,2
    		F,--2998261(+) GAGTAC/TCAACT 9 -- us2k1 ut31 nc-transcript-variant1Minor allele frequency- T:0.09WA 118
    rs1860616991,2
    		--2998301(+) CCTGAC/TGGATG 9 -- us2k1 ut31 nc-transcript-variant0--------
    rs1404654761,2
    		C,--2998328(+) TGTGA-/CTCTATG 9 -- ut31 nc-transcript-variantus2k10--------
    rs2000843231,2
    		--2998331(+) GACTC-/TATGGTT 9 -- us2k1 ut31 nc-transcript-variant0--------
    rs1429260911,2
    		--2998338(+) TGGTTG/TACTGC 9 -- us2k1 ut31 nc-transcript-variant0--------
    rs1481059781,2
    		--2998427(+) AGATG-/AGGG  
      GAGATA    AGGGG     		9 -- ut31 nc-transcript-variantus2k10--------
    rs110624011,2
    		C,F,H,--2998459(+) TTCTTT/CAGGAT 9 -- ut31 nc-transcript-variantus2k117Minor allele frequency- C:0.15NS EA WA NA 2220
    rs595593781,2
    		C,--2998467(+) GATTGC/TGTGTG 9 -- us2k1 ut31 nc-transcript-variant1Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for TULP3 (2986389 - 3050306 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TULP3
         1 CNV: 4766
    Human Gene Mutation Database (HGMD): TULP3

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TULP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TULP3 for disorders           About GeneDecksing

    OMIM gene information: 604730    OMIM disorders: --

    2 diseases for TULP3:    About MalaCards
    neuronitis    thyroiditis

    Human Genome Epidemiology (HuGE) Navigator: TULP3 (2 documents)

    Export disorders for TULP3 gene to outside databases

    Publications
    for TULP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TULP3 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TULP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans. (PubMed id 9828123)1, 2, 3, 9 Nishina P.M.... Naggert J.K. (1998)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. G-protein signaling through tubby proteins. (PubMed id 11375483)1, 2 Santagata S.... Shapiro L. (2001)
    5. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. (PubMed id 20889716)2 Mukhopadhyay S....Jackson P.K. (2010)
    10. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)

    External Searches for TULP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TULP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7289 HGNC: 12425 AceView: TULP3 Ensembl:ENSG00000078246 euGenes: HUgn7289
    ECgene: TULP3 H-InvDB: TULP3

    Other Databases showing TULP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TULP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TULP3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TULP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TULP3 gene:
    Search GeneIP for patents involving TULP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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