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Aliases for TULP2 Gene

Aliases for TULP2 Gene

  • Tubby Like Protein 2 2 3 5
  • Cancer/Testis Antigen 65 2 4
  • TUBL2 3 4
  • CT65 3 4
  • Cancer Testis Antigen 65 3
  • Tubby-Related Protein 2 3
  • Tubby-Like Protein 2 4

External Ids for TULP2 Gene

Previous GeneCards Identifiers for TULP2 Gene

  • GC19M050042
  • GC19M049751
  • GC19M054060
  • GC19M054076
  • GC19M049384
  • GC19M045760

Summaries for TULP2 Gene

Entrez Gene Summary for TULP2 Gene

  • TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. [provided by RefSeq, Jul 2008]

GeneCards Summary for TULP2 Gene

TULP2 (Tubby Like Protein 2) is a Protein Coding gene. GO annotations related to this gene include protein complex binding. An important paralog of this gene is TUB.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TULP2 Gene

Genomics for TULP2 Gene

Regulatory Elements for TULP2 Gene

Enhancers for TULP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048871 1.7 Ensembl ENCODE dbSUPER 17.7 +24.2 24170 8.8 CREB3L1 AGO1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D FLT3LG PRR12 TULP2 HSD17B14 SNORD35B ALDH16A1 SNORD35A RPS11 PIH1D1 RPL18
GH19G048880 1.5 Ensembl ENCODE dbSUPER 18 +18.7 18659 1.8 ATF1 CREB3L1 ETS1 ZNF121 ZNF766 ELK1 ZNF143 KLF13 CAVIN1 ZNF592 RRAS TULP2 PRR12 EMP3 NUCB1 FLT3LG TEAD2 ENSG00000268157 IRF3 GC19M048876
GH19G048958 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -63.8 -63846 10.2 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PPP1R15A PRR12 NUP62 IZUMO1 RUVBL2 CA11 SEC1P SNORD35B C19orf68 ALDH16A1
GH19G048977 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -79.0 -78963 2.9 PKNOX1 ATF1 SIN3A GLIS2 ZNF143 FOS SP3 JUNB TSHZ1 ZNF623 NUCB1-AS1 NUCB1 KCNA7 TULP2 CGB7 NTF4 C19orf73 FUT1 GYS1 GC19P048966
GH19G048898 1.1 ENCODE 17.6 -0.1 -58 3.8 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 NUCB1 TULP2 PPP1R15A PLEKHA4 BAX FTL DBP SEC1P IRF3 NUCB1-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TULP2 on UCSC Golden Path with GeneCards custom track

Promoters for TULP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110799 -316 1801 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for TULP2 Gene

Chromosome:
19
Start:
48,880,822 bp from pter
End:
48,900,184 bp from pter
Size:
19,363 bases
Orientation:
Minus strand

Genomic View for TULP2 Gene

Genes around TULP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TULP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TULP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TULP2 Gene

Proteins for TULP2 Gene

  • Protein details for TULP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00295-TULP2_HUMAN
    Recommended name:
    Tubby-related protein 2
    Protein Accession:
    O00295
    Secondary Accessions:
    • Q8TC50

    Protein attributes for TULP2 Gene

    Size:
    520 amino acids
    Molecular mass:
    58664 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TULP2 Gene

Post-translational modifications for TULP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TULP2 Gene

Domains & Families for TULP2 Gene

Protein Domains for TULP2 Gene

Suggested Antigen Peptide Sequences for TULP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00295

UniProtKB/Swiss-Prot:

TULP2_HUMAN :
  • Belongs to the TUB family.
Family:
  • Belongs to the TUB family.
genes like me logo Genes that share domains with TULP2: view

No data available for Gene Families for TULP2 Gene

Function for TULP2 Gene

Molecular function for TULP2 Gene

GENATLAS Biochemistry:
tubby-like protein 2,weakly expressed in retina,highly in testis

Gene Ontology (GO) - Molecular Function for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 20889716
GO:0035091 phosphatidylinositol binding IBA --
genes like me logo Genes that share ontologies with TULP2: view
genes like me logo Genes that share phenotypes with TULP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TULP2

CRISPR Products

miRNA for TULP2 Gene

miRTarBase miRNAs that target TULP2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TULP2 Gene

Localization for TULP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TULP2 Gene

Cytoplasm. Secreted. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TULP2 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
GO:0005929 cilium IBA --
genes like me logo Genes that share ontologies with TULP2: view

Pathways & Interactions for TULP2 Gene

SuperPathways for TULP2 Gene

No Data Available

Interacting Proteins for TULP2 Gene

Gene Ontology (GO) - Biological Process for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 9096357
GO:0097500 receptor localization to non-motile cilium IBA --
GO:1903546 protein localization to photoreceptor outer segment IBA --
genes like me logo Genes that share ontologies with TULP2: view

No data available for Pathways by source and SIGNOR curated interactions for TULP2 Gene

Drugs & Compounds for TULP2 Gene

No Compound Related Data Available

Transcripts for TULP2 Gene

Unigene Clusters for TULP2 Gene

Tubby like protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TULP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: -

Relevant External Links for TULP2 Gene

GeneLoc Exon Structure for
TULP2
ECgene alternative splicing isoforms for
TULP2

Expression for TULP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TULP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TULP2 Gene

This gene is overexpressed in Testis (x36.3).

Protein differential expression in normal tissues from HIPED for TULP2 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TULP2 Gene



Protein tissue co-expression partners for TULP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TULP2 Gene:

TULP2

SOURCE GeneReport for Unigene cluster for TULP2 Gene:

Hs.104636

mRNA Expression by UniProt/SwissProt for TULP2 Gene:

O00295-TULP2_HUMAN
Tissue specificity: Strongly expressed in testis. Also expressed in retina. Expressed in cancer cell lines.

Evidence on tissue expression from TISSUES for TULP2 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TULP2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TULP2 Gene

Orthologs for TULP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TULP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TULP2 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia TULP2 34 35
  • 77.35 (n)
cow
(Bos Taurus)
Mammalia TULP2 34 35
  • 76.05 (n)
rat
(Rattus norvegicus)
Mammalia Tulp2 34
  • 69.81 (n)
mouse
(Mus musculus)
Mammalia Tulp2 34 16 35
  • 68.82 (n)
oppossum
(Monodelphis domestica)
Mammalia TULP2 35
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TULP2 35
  • 32 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TULP2 35
  • 31 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta king-tubby 35
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tub-1 36 35
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToMany
Species where no ortholog for TULP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TULP2 Gene

ENSEMBL:
Gene Tree for TULP2 (if available)
TreeFam:
Gene Tree for TULP2 (if available)

Paralogs for TULP2 Gene

Paralogs for TULP2 Gene

(3) SIMAP similar genes for TULP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TULP2: view

Variants for TULP2 Gene

Sequence variations from dbSNP and Humsavar for TULP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000028104 -- 48,897,360(+) AGCTT(A/C)TGCAG intron-variant, nc-transcript-variant, reference, missense
rs1000113043 -- 48,889,569(+) TCCCA(C/T)ATTGG nc-transcript-variant, reference, missense
rs1000307076 -- 48,883,724(+) CATTG(A/G)CCCAG intron-variant
rs1000446799 -- 48,888,349(+) GGTCC(C/T)GCCCT intron-variant
rs1000490397 -- 48,880,428(+) CGGCC(A/T)CCGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TULP2 Gene

Variant ID Type Subtype PubMed ID
esv2670526 CNV deletion 23128226
esv3644604 CNV loss 21293372
esv3644605 CNV loss 21293372
esv3644606 CNV loss 21293372
esv3644607 CNV insertion 21293372
nsv470148 CNV gain 18288195
nsv833855 CNV loss 17160897
nsv833856 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for TULP2 Gene

Residual Variation Intolerance Score: 94.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.21; 76.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TULP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TULP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TULP2 Gene

Disorders for TULP2 Gene

Relevant External Links for TULP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TULP2

No disorders were found for TULP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TULP2 Gene

Publications for TULP2 Gene

  1. Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PMID: 9096357) North M.A. … Nishina P.M. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PMID: 21248752) Varela I. … Futreal P.A. (Nature 2011) 4 64
  5. TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. (PMID: 20889716) Mukhopadhyay S. … Jackson P.K. (Genes Dev. 2010) 3 64

Products for TULP2 Gene

Sources for TULP2 Gene

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