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Aliases for TULP2 Gene

Aliases for TULP2 Gene

  • Tubby Like Protein 2 2 3
  • Cancer/Testis Antigen 65 2 3 4
  • Tubby-Like Protein 2 3 4
  • TUBL2 3 4
  • CT65 3 4
  • Cancer Testis Antigen 65 3
  • Tubby-Related Protein 2 3

External Ids for TULP2 Gene

Previous GeneCards Identifiers for TULP2 Gene

  • GC19M050042
  • GC19M049751
  • GC19M054060
  • GC19M054076
  • GC19M049384
  • GC19M045760

Summaries for TULP2 Gene

Entrez Gene Summary for TULP2 Gene

  • TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. [provided by RefSeq, Jul 2008]

GeneCards Summary for TULP2 Gene

TULP2 (Tubby Like Protein 2) is a Protein Coding gene. An important paralog of this gene is TUB.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TULP2 Gene

Genomics for TULP2 Gene

Regulatory Elements for TULP2 Gene

Genomic Location for TULP2 Gene

48,880,849 bp from pter
48,898,832 bp from pter
17,984 bases
Minus strand

Genomic View for TULP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TULP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TULP2 Gene

Proteins for TULP2 Gene

  • Protein details for TULP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubby-related protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8TC50

    Protein attributes for TULP2 Gene

    520 amino acids
    Molecular mass:
    58664 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TULP2 Gene

Proteomics data for TULP2 Gene at MOPED

Post-translational modifications for TULP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TULP2 Gene

No data available for DME Specific Peptides for TULP2 Gene

Domains for TULP2 Gene

Protein Domains for TULP2 Gene


Suggested Antigen Peptide Sequences for TULP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O00295
  • Belongs to the TUB family.
genes like me logo Genes that share domains with TULP2: view

No data available for Gene Families for TULP2 Gene

Function for TULP2 Gene

Molecular function for TULP2 Gene

GENATLAS Biochemistry: tubby-like protein 2,weakly expressed in retina,highly in testis

Gene Ontology (GO) - Molecular Function for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032403 protein complex binding IDA 20889716
genes like me logo Genes that share ontologies with TULP2: view

Phenotypes for TULP2 Gene

genes like me logo Genes that share phenotypes with TULP2: view

Animal Model Products

CRISPR Products

miRNA for TULP2 Gene

miRTarBase miRNAs that target TULP2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TULP2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TULP2 Gene

Localization for TULP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TULP2 Gene

Cytoplasm. Secreted. Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TULP2 Gene COMPARTMENTS Subcellular localization image for TULP2 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TULP2: view

Pathways for TULP2 Gene

SuperPathways for TULP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TULP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007601 visual perception TAS 9096357
genes like me logo Genes that share ontologies with TULP2: view

No data available for Pathways by source for TULP2 Gene

Transcripts for TULP2 Gene

Unigene Clusters for TULP2 Gene

Tubby like protein 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TULP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TULP2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: -

Relevant External Links for TULP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TULP2 Gene

mRNA expression in normal human tissues for TULP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TULP2 Gene

This gene is overexpressed in Testis (36.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TULP2 Gene

SOURCE GeneReport for Unigene cluster for TULP2 Gene Hs.104636

mRNA Expression by UniProt/SwissProt for TULP2 Gene

Tissue specificity: Strongly expressed in testis. Also expressed in retina. Expressed in cancer cell lines.
genes like me logo Genes that share expressions with TULP2: view

In Situ Assay Products

Orthologs for TULP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TULP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TULP2 35
  • 99.42 (n)
  • 98.85 (a)
TULP2 36
  • 99 (a)
(Bos Taurus)
Mammalia TULP2 35
  • 76.05 (n)
  • 63.87 (a)
TULP2 36
  • 63 (a)
(Canis familiaris)
Mammalia TULP2 35
  • 77.35 (n)
  • 64.08 (a)
TULP2 36
  • 63 (a)
(Mus musculus)
Mammalia Tulp2 35
  • 68.82 (n)
  • 58.59 (a)
Tulp2 16
Tulp2 36
  • 51 (a)
(Monodelphis domestica)
Mammalia TULP2 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
(Rattus norvegicus)
Mammalia Tulp2 35
  • 69.81 (n)
  • 58.65 (a)
(Anolis carolinensis)
Reptilia TULP2 36
  • 32 (a)
(Danio rerio)
Actinopterygii TULP2 36
  • 31 (a)
fruit fly
(Drosophila melanogaster)
Insecta king-tubby 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea tub-1 36
  • 35 (a)
tub-1 37
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for TULP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TULP2 Gene

Gene Tree for TULP2 (if available)
Gene Tree for TULP2 (if available)

Paralogs for TULP2 Gene

Paralogs for TULP2 Gene

Selected SIMAP similar genes for TULP2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TULP2: view

Variants for TULP2 Gene

Sequence variations from dbSNP and Humsavar for TULP2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs173470 -- 48,881,206(+) ttttt(A/T)ttttc intron-variant
rs1005061 -- 48,881,974(-) GTGAA(C/T)GGAAG intron-variant
rs1052853 -- 48,885,487(-) TACAC(A/T)CCTAT reference, missense
rs1466896 -- 48,881,996(-) CAGGT(C/G)GGGTG intron-variant
rs1967200 -- 48,885,812(-) TGCCC(C/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TULP2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833855 CNV Loss 17160897
nsv912245 CNV Loss 21882294
dgv3969n71 CNV Gain 21882294
nsv833856 CNV Loss 17160897
nsv470148 CNV Gain 18288195
esv2670526 CNV Deletion 23128226

Relevant External Links for TULP2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TULP2 Gene

Disorders for TULP2 Gene

(1) Novoseek inferred disease relationships for TULP2 Gene

Disease -log(P) Hits PubMed IDs
retinal degeneration 76.2 1
genes like me logo Genes that share disorders with TULP2: view

No data available for UniProtKB/Swiss-Prot for TULP2 Gene

Publications for TULP2 Gene

  1. Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PMID: 9096357) North M.A. … Nishina P.M. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans. (PMID: 9828123) Nishina P.M. … Naggert J.K. (Genomics 1998) 23
  3. GFP-tagged expression and immunohistochemical studies to determine the subcellular localization of the tubby gene family members. (PMID: 11000483) He W. … Naggert J.K. (Brain Res. Mol. Brain Res. 2000) 23
  4. Molecular cloning, expression and regulation of the avian tubby-like protein 1 (tulp1) gene. (PMID: 11483369) HeikenwAolder M.F. … Zenke M. (Gene 2001) 23
  5. Implication of tubby proteins as transcription factors by structure-based functional analysis. (PMID: 10591637) Boggon T.J. … Shapiro L. (Science 1999) 3

Products for TULP2 Gene

Sources for TULP2 Gene

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