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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TULP2 Gene

protein-coding GIFtS: 54
GCID: GC19M049384

tubby like protein 2

Explore 3 diseases affiliated with
TULP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubby Like Protein 2¹ ²		Tubby-Like Protein 2² ³
CT65¹ ² ³		Cancer Testis Antigen 65²
TUBL2¹ ² ³		Tubby-Related Protein 2²
Cancer/Testis Antigen 65² ³

External Ids:	HGNC: 12424¹	Entrez Gene: 7288²	Ensembl: ENSG00000104804⁷	OMIM: 602309⁵	UniProtKB: O00295³

Export aliases for TULP2 gene to outside databases

Previous GC identifers: GC19M050042 GC19M049751 GC19M054060 GC19M054076 GC19M045760

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TULP2:

TULP2 is a member of a family of tubby-like genes (TULPs) that encode proteins of unknown function. Members of this

family have been identified in plants, vertebrates, and invertebrates. The TULP proteins share a conserved C-terminal

region of approximately 200 amino acid residues. (provided by RefSeq, Jul 2008)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TULP2 gene promoter:
STAT1 RP58 Olf-1 CUTL1 Tal-1beta E47 AREB6 Ik-2 SEF-1 (1)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TULP2 promoter sequence

Search SABiosciences Chromatin IP Primers for TULP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TULP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.1

TULP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TULP2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M049384: view genomic region (about GC identifiers)

Start:	49,384,222 bp from pter	End:	49,401,996 bp from pter
Size:	17,775 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TULP2_HUMAN, O00295 (See protein sequence)

Recommended Name: Tubby-related protein 2

Size: 520 amino acids; 58664 Da

Subcellular location: Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal

peptide and is secreted by a non-conventional pathway (By similarity)

Secondary accessions: Q8TC50

Explore the universe of human proteins at neXtProt for TULP2: NX_O00295

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00295

TULP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003314.2

ENSEMBL proteins:

ENSP00000221399 ENSP00000429131 ENSP00000428420 ENSP00000430040 ENSP00000428535

ENSP00000429658

Human Recombinant Protein Products:

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	Novus Biologicals TULP2 Proteins Novus Biologicals TULP2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TULP2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005737	cytoplasm	IEA	--

TULP2 for ontologies About GeneDecksing

TULP2 Antibody Products:

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	Novus Biologicals TULP2 Antibodies
	Search for Antibodies for TULP2 at Abcam
	Uscn Antibodies for TULP2
	Search ThermoFisher Antibodies for TULP2

Assay Products for TULP2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TULP2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TULP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TULP2 for domains About GeneDecksing

4 InterPro domains/families:

IPR025659 Tubby_C-like

IPR018066 Tubby_C_CS

IPR005398 Tubby_N

IPR000007 Tubby_C

Graphical View of Domain Structure for InterPro Entry O00295

ProtoNet protein and cluster: O00295

1 Blocks protein family: IPB000007 Tubby

UniProtKB/Swiss-Prot: TULP2_HUMAN, O00295

Similarity: Belongs to the TUB family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for TULP2:

tubby-like protein 2,weakly expressed in retina,highly in testis

miRNA Products:		OriGene 3'-UTR Clone: TULP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TULP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TULP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TULP2 (see all 7) OriGene shRNA RFP: TULP2 OriGene siRNA: TULP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TULP2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TULP2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TULP2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TULP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TULP2 (NM_003323)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TULP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TULP2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TULP2
		Search LifeMap BioReagents cell lines for TULP2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP2

2 GenomeRNAi human phenotypes for TULP2:

Decreased Wnt reporter activit

Increased gamma-H2AX phosphory

Animal Models:
1 MGI phenotypic allele

for Tulp2 (no phenotypes)

TULP2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TULP2

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5/6 Interacting proteins for TULP2 (O00295^{2, 3} ENSP00000221399⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MEOX2	P50222²^,³, ENSP00000262041⁴	MINT-67735 I2D: score=5 STRING: ENSP00000262041
EWSR1	Q01844³, ENSP00000381031⁴	I2D: score=3 STRING: ENSP00000381031
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
--	Q9BWA2³^,²	MINT-66842 I2D: score=1
--	Q9BWA2³^,²	MINT-66842 I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007601	visual perception	TAS	9096357

TULP2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for TULP2:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TULP2
Search CenterWatch for drugs/clinical trials and news about TULP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TULP2 gene:

NM_003323.2

Unigene Cluster for TULP2:

Tubby like protein 2

Hs.104636 [show with all ESTs]

Unigene Representative Sequence: NM_003323

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000221399(uc002pkz.2) ENST00000522341 ENST00000518572 ENST00000522945

ENST00000520977 ENST00000522229

miRNA Products:		OriGene 3'-UTR Clone: TULP2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TULP2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TULP2
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TULP2 (see all 7) OriGene shRNA RFP: TULP2 OriGene siRNA: TULP2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TULP2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TULP2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TULP2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TULP2 (NM_003323)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TULP2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TULP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TULP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TULP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TULP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TULP2

Additional cDNA sequence:

BC026070.2 U82469.1

1 DOTS entry:

DT.308924

24/27 AceView cDNA sequences (see all 27):

BX103015 AA460020 U82469 NM_003323 BI827967 AW452476 BC026070 AW594133

AW274889 AI806947 BI828528 AA961794 BF061810 AW590860 AI917810 BI464372

BG772536 AI654642 AW873490 AA884015 AA883213 AI027650 AI631622 AA723710

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TULP2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12
SP1:
SP2:																					-

ECgene alternative splicing isoforms for TULP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TULP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GACTTCTGCT

About this image

TULP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TULP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TULP2

SOURCE GeneReport for Unigene cluster: Hs.104636

UniProtKB/Swiss-Prot: TULP2_HUMAN, O00295

Tissue specificity: Strongly expressed in testis. Also expressed in retina. Expressed in cancer cell lines

SABiosciences Custom PCR Arrays for TULP2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TULP2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TULP2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TULP2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TULP2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TULP2 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tulp2^{1 , 5}	tubby-like protein 2^{1, 5}	69.07(n)¹ 57.59(a)¹		7 (29.33 cM)⁵ 56734¹ NM_008807.2¹ NP_032833.2¹ 45486262⁵
lizard (Anolis carolinensis)	Reptilia	TULP2⁶	--	40(a)	1 ↔ 1	GL343355.1(542191-560653)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-220f10.4⁶	si:dkey-220f10.4	31(a)	1 ↔ 1	12(21970133-21978175)
fruit fly (Drosophila melanogaster)	Insecta	king-tubby⁶	king tubby	33(a)	1 → many	2R(16989435-17011220)
worm (Caenorhabditis elegans)	Secernentea	tub-1³	Tub family protein tub-1	49(a)		II(8154693-8156859) --
thale cress (Arabidopsis thaliana)	eudicotyledons	TLP11⁶ TLP3⁶ (see all 11)	Tubby-like F-box protein 3 (see all 11)	26(a) 24(a) (see all 11)	many ↔ many many ↔ many (see all 11)	5(6228165-6230537) 2(19610923-19613232)
rice (Oryza sativa)	Liliopsida	-- -- (see all 14)	OsFBT11 - F-box and tubby domain containing protei... OsFBT1 - F-box and tubby domain containing protein... (see all 14)	25(a) 25(a) (see all 14)	many ↔ many many ↔ many (see all 14)	7(28172007-28175827) 1(27715144-27720173)

ENSEMBL Gene Tree for TULP2 (if available)
TreeFam Gene Tree for TULP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TULP2 gene

TULP4² TUB² TULP1² WDR35² TULP3²

3 SIMAP similar genes for TULP2 using alignment to 5 protein entries: TULP2_HUMAN (see all proteins):

TULP1 TUB TULP3

TULP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs113500195^1,2	C,F,	--	49383755(+)	`GACGGG/AGTTTG`	1	--	int¹		1		NA	120
rs144396741^1,2		--	49383832(+)	`TGTTGA/GGATTC`	1	--	int¹		0	--	--	--	--
rs186765412^1,2		--	49383912(+)	`AAGTGA/GAGCTA`	1	--	int¹		0	--	--	--	--
rs139071359^1,2		--	49383988(+)	`GCTGGA/GATTAC`	1	--	int¹		0	--	--	--	--
rs149909240^1,2		--	49384057(+)	`ATGTTC/GGCCAG`	1	--	int¹		0	--	--	--	--
rs144878548^1,2		--	49384072(+)	`GTCTCA/GATCTC`	1	--	int¹		0	--	--	--	--
rs9973310^1,2	C,F,A,H,	--	49384074(+)	`CTCGAT/ACTCCT`	1	--	int¹		8		NA CSA EA	251
rs115388116^1,2	C,F,	--	49384272(+)	`TCTAAT/CTGAAA`	2	/N /S	mis¹		2		WA NA	4670
rs145363054^1,2	C,F	--	49384276(+)	`ATTGAA/GACTGG`	2	L F	mis¹		1		NA	4552
rs149397864^1,2	C,	--	49384284(+)	`TGGACA/GAGCAG`	2	S L	mis¹		1		NA	4552

HapMap Linkage Disequilibrium report for TULP2 (49384222 - 49401996 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TULP2
3 CNVs: 5108 5107 32261

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TULP2

DNA2.0 Custom Variant and Variant Library Synthesis for TULP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TULP2 for disorders           About GeneDecksing

OMIM gene information: 602309    OMIM disorders: --

3 diseases for TULP2:    About MalaCards

retinal degeneration retinitis neuronitis

1 Novoseek disease relationship for TULP2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinal degeneration	76.2	1	9096357 (1)

Export disorders for TULP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TULP2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TULP2)

Utopia: connect your pdf to the dynamic
world of online information

Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PubMed id 9096357)^{1, 2, 3, 9} North M.A.... Nishina P.M. (1997)
Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)¹ Woods N.T....Monteiro A.N. (2012)
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. (PubMed id 21248752)² Varela I....Futreal P.A. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)¹ Rual J.F....Vidal M. (2005)
Identification of cancer/testis-antigen genes by massively parallel signature sequencing. (PubMed id 15905330)² Chen Y.-T.... Simpson A.J.G. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Tubby proteins: the plot thickens. (PubMed id 14708010)¹ Carroll K....Shapiro L. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Implication of tubby proteins as transcription factors by structure-based functional analysis. (PubMed id 10591637)¹ Boggon T.J....Shapiro L. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7288	HGNC: 12424	AceView: TULP2	Ensembl:ENSG00000104804	euGenes: HUgn7288
ECgene: TULP2	H-InvDB: TULP2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TULP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TULP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TULP2 gene:
Search GeneIP for patents involving TULP2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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	EMD Millipore small molecules (inhibitor) for TULP2
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	Browse OriGene Antibodies		OriGene shRNA RFP for TULP2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TULP2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TULP2
	OriGene Protein Over-expression Lysate for TULP2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TULP2		OriGene 3'-UTR Clone for TULP2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TULP2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TULP2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TULP2		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TULP2		OriGene Custom Protein Services for TULP2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TULP2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TULP2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TULP2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TULP2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TULP2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TULP2

	GenScript Custom Purified and Recombinant Proteins Services for TULP2		GenScript cDNA clones with any tag delivered in your preferred vector for TULP2
	GenScript Custom Assay Services for TULP2		GenScript Custom Superior Antibodies Services for TULP2
	GenScript Custom overexpressing Cell Line Services for TULP2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	Regulatory tfbs in TULP2 promoter
	Search Chromatin IP Primers for TULP2
	RT² qPCR Primer Assay in human, mouse, rat TULP2
	Search GNC Networks for TULP2
	SABiosciences Custom PCR Arrays for TULP2

Search Tocris compounds for TULP2

	Browse Sino Biological Proteins and Antibodies
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	TULP2 lysates

	Search for Antibodies for TULP2 at Abcam
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Browse ProSpec Recombinant Proteins

TULP2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TULP2

	Gene Synthesis
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TULP2

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TULP2
	SwitchGear Promoter luciferase reporter plasmids for TULP2

Search ThermoFisher Antibodies for TULP2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TULP2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TULP2 Gene

tubby like protein 2

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TULP2 Gene

tubby like protein 2

Aliasesfor TULP2 gene

Summariesfor TULP2 gene

Genomic Viewsfor TULP2 gene

Proteinsfor TULP2 gene

Protein Domains /Familiesfor TULP2 gene

Functionfor TULP2 gene

Pathways & Interactionsfor TULP2 gene

Drugs & Compoundsfor TULP2 gene

Transcriptsfor TULP2 gene

Expression for TULP2 gene

Orthologsfor TULP2 gene

Paralogsfor TULP2 gene

Genomic Variantsfor TULP2 gene

Disorders / Diseasesfor TULP2 gene

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External Searches for TULP2 gene

Genome Databases showing TULP2 gene

Other Databases showing TULP2 gene

Specialized Databases showing TULP2 gene

Intellectual Propertyfor TULP2 gene

Productsfor TULP2 gene

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Aliases
for TULP2 gene

Summaries
for TULP2 gene

Genomic Views
for TULP2 gene

Proteins
for TULP2 gene

Protein Domains /
Families
for TULP2 gene

Function
for TULP2 gene

Pathways & Interactions
for TULP2 gene

Drugs & Compounds
for TULP2 gene

Transcripts
for TULP2 gene

Expression
for TULP2 gene

Orthologs
for TULP2 gene

Paralogs
for TULP2 gene

Genomic Variants
for TULP2 gene

Disorders / Diseases
for TULP2 gene

Publications
for TULP2 gene

Intellectual Property
for TULP2 gene

Products
for TULP2 gene