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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TULP1 Gene

protein-coding   GIFtS: 61
GCID: GC06M035465

tubby like protein 1


(Previous symbol: RP14)
 Explore 17 diseases affiliated with
TULP1 via our new
 Human Malady Compendium 
Biological research products
for TULP1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tubby Like Protein 11 2
TUBL11 2 3
RP141 2 5
LCA152
Tubby-Related Protein 12
Tubby-Like Protein 13

External Ids:    HGNC: 124231   Entrez Gene: 72872   Ensembl: ENSG000001120417   OMIM: 6022805   UniProtKB: O002943   

Export aliases for TULP1 gene to outside databases

Previous GC identifers: GC06M035467 GC06M035512 GC06M035573 GC06M035186


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TULP1:
This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in
plants, vertebrates, and invertebrates and encode proteins of unknown function. TULP proteins share a conserved
C-terminal region of approximately 200 amino acid residues. Mutations in this gene may be associated with retinitis
pigmentosa. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TULP1_HUMAN, O00294
Function: Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for
long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein
transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate,
phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate,
phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic
acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and
macrophages

Gene Wiki entry for TULP1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TULP1 gene promoter:
         E2F-3a   E2F-4   E2F-5   GATA-3   MIF-1   AP-4   E2F-2   Pax-2b   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTULP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TULP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TULP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21.3

TULP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TULP1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035465:  view genomic region     (about GC identifiers)

Start:
35,465,651 bp from pter      End:
35,480,715 bp from pter
Size:
15,065 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TULP1_HUMAN, O00294 (See protein sequence)
Recommended Name: Tubby-related protein 1  
Size: 542 amino acids; 60609 Da
Subunit: Homodimer (Probable). May interact with ABCF1, PSIP1, ZEB1 and HMGB2 (Potential). Interacts with DNM1 (By
similarity). Interacts with F-actin. Interacts with TUB (By similarity). Interacts with TYRO3 (By similarity)
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Secreted (By
similarity). Cell junction, synapse (By similarity). Note=Detected at synapses between photoreceptor cells and
second-order neurons. Does not have a cleavable signal peptide and is secreted by an alternative pathway (By
similarity)
Sequence caution: Sequence=CAI20251.1; Type=Erroneous gene model prediction;
2 PDB 3D structures from and Proteopedia for TULP1:
2FIM (3D)        3C5N (3D)    
Secondary accessions: O43536 Q5TGM5 Q8N571
Alternative splicing: 2 isoforms:  O00294-1   O00294-2   

Explore the universe of human proteins at neXtProt for TULP1: NX_O00294

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O00294

  • TULP1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003313.3  
    ENSEMBL proteins: 
     ENSP00000319414   ENSP00000229771   ENSP00000406765  

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    Uscn Proteins for TULP1

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001750photoreceptor outer segment ISS--
    GO:0001917photoreceptor inner segment ISS--
    GO:0005576extracellular region IEA--
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane IDA16303976


    TULP1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TULP1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR025659 Tubby_C-like
     IPR018066 Tubby_C_CS
     IPR000007 Tubby_C

    Graphical View of Domain Structure for InterPro Entry O00294

    ProtoNet protein and cluster: O00294

    1 Blocks protein family: IPB000007 Tubby

    UniProtKB/Swiss-Prot: TULP1_HUMAN, O00294
    Similarity: Belongs to the TUB family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TULP1_HUMAN, O00294
    Function: Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for
    long-term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein
    transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate,
    phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate,
    phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic
    acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and
    macrophages

         Genatlas biochemistry entry for TULP1:
    tubby-like protein 1,highly expressed in retina,in photoreceptor cells,involved in normal photoreceptor function and in
    retinal development

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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI17474147
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IDA16303976
    GO:0008020G-protein coupled photoreceptor activity IEA--
    GO:0051015actin filament binding IDA16303976


    TULP1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TULP1:
     Decreased Salmonella enterica  

    Animal Models:
         Mouse knock-out Tulp1tm1Pjn for TULP1
         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tulp1):
     cardiovascular system  cellular  growth/size  hearing/vestibular/ear  nervous system 
     pigmentation  vision/eye 

    TULP1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TULP1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TULP1 (O002941, 3 ENSP000002297714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 3, ENSP000002889864EBI-1756778,EBI-3448658 I2D: score=1 STRING: ENSP00000288986
    FYNP062413, ENSP000003576564I2D: score=1 STRING: ENSP00000357656
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006909phagocytosis IEA--
    GO:0007601visual perception TAS9462750
    GO:0007602phototransduction IEA--
    GO:0009584detection of visible light ----
    GO:0016358dendrite development ISS--


    TULP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TULP1
    Search CenterWatch for drugs/clinical trials and news about TULP1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TULP1 gene: 
    NM_003322.3  

    Unigene Cluster for TULP1:

    Tubby like protein 1
    Hs.485208  [show with all ESTs]
    Unigene Representative Sequence: U82468
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000322263(uc003okw.4) ENST00000229771(uc003okv.4 uc021yyx.1 uc021yyy.1)
    ENST00000495781 ENST00000496434 ENST00000373892 ENST00000428978 ENST00000448446


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    Additional cDNA sequence: 

    AB593123.1 AB593124.1 BC032714.1 BC065261.1 DQ426893.1 U82468.1 

    7 DOTS entries:

    DT.100021739  DT.91849174  DT.408796  DT.99984046  DT.91660628  DT.91975618  DT.97803463 

    24/47 AceView cDNA sequences (see all 47):

    BM671162 BQ638611 BM672988 BM710012 BU729804 BM690201 BM663859 BX491387 
    BE780807 BU193288 AI380477 BE618519 CA392792 BM715213 BU159914 BX091600 
    BM702753 BU681480 BC065261 U82468 BE778818 AI344222 BM662140 BC032714 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TULP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTGCGGAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See TULP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TULP1

    SOURCE GeneReport for Unigene cluster: Hs.485208

    UniProtKB/Swiss-Prot: TULP1_HUMAN, O00294
    Tissue specificity: Retina-specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TULP1 gene from 7/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TULP11 tubby like protein 1 70.09(n)
    70.09(a)
      395321  NM_204615.1  NP_989946.1 
    lizard
    (Anolis carolinensis)
    Reptilia TULP16
    --
    66(a)
    1 ↔ 1
    GL343382.1(955054-984325)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003307541 tubby-related protein 1-like 66.33(n)
    70.67(a)
      100330754  XM_002667658.2  XP_002667704.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tulp3   -- 60(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea tub-13 Tub family protein tub-1 58(a)   II(8154693-8156859)   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AtTLP76
    TLP36
    (see all 11)
    Tubby-like F-box protein 3
    (see all 11)
    27(a)
    26(a)
    (see all 11)
    many ↔ many
    many ↔ many
    (see all 11)
    1(19891014-19893504)
    2(19610923-19613232)
    rice
    (Oryza sativa)
    Liliopsida Os03g03514001 hypothetical protein 49.05(n)
    43.09(a)
      4332845  NM_001056652.1  NP_001050117.1 


    ENSEMBL Gene Tree for TULP1 (if available)
    TreeFam Gene Tree for TULP1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TULP1 gene
    TULP22  TULP42  TUB2  WDR352  TULP32  
    3 SIMAP similar genes for TULP1 using alignment to 5 protein entries:     TULP1_HUMAN (see all proteins):
    TULP3    TULP2    TUB

    TULP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/321 NCBI SNPs in TULP1 are shown (see all 321    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1219090751,2
    C,F,pathogenic35467877(-) CCTCAA/C/TAGAAC 3 K T I mis11NA 4552
    rs768089671,2
    F,--35466870(+) GGCTCG/ACTCAA 1 -- int11Minor allele frequency- A:0.03NA 120
    rs37983441,2
    C,F,A,H,--35466900(+) ACCCAG/CAGACT 1 -- int17Minor allele frequency- C:0.12WA CSA NA EA 365
    rs1414682741,2
    --35466988(+) GGACAC/TCTTGT 1 -- int10--------
    rs1470077411,2
    --35467032(+) CACTTC/GAGAGA 1 -- int10--------
    rs1480464571,2
    --35467088(+) AAAAGA/GCAACC 1 -- int10--------
    rs1173272381,2
    --35467243(+) GGGACG/ATTGAA 1 -- int11Minor allele frequency- A:0.01EA 120
    rs1408052951,2
    --35467368(+) GCTGAC/GAGACT 1 -- int10--------
    rs1808814261,2
    --35467440(+) TGTCCA/GTGGTT 1 -- int10--------
    rs1128017501,2
    C,--35467461(+) GGAGCT/-CAACC 1 -- int11Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for TULP1 (35465651 - 35480715 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TULP1
         2 CNVs: 69486 3607
         1 Indel: 47114
    Human Gene Mutation Database (HGMD): TULP1

    Locus Specific Mutation Databases (LSDB): TULP1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TULP1
    DNA2.0 Custom Variant and Variant Library Synthesis for TULP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TULP1 for disorders           About GeneDecksing

    OMIM gene information: 602280   
    OMIM disorders: 600132  
    UniProtKB/Swiss-Prot: TULP1_HUMAN, O00294
  • Defects in TULP1 are the cause of retinitis pigmentosa type 14 (RP14) [MIM:600132]. RP leads to degeneration
  • of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field.
    As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP14
    inheritance is autosomal recessive
  • Defects in TULP1 are the cause of Leber congenital amaurosis type 15 (LCA15) [MIM:613843]. LCA15 is a severe
  • dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and
    often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and
    keratoconus

    17 diseases for TULP1:    About MalaCards
    retinitis pigmentosa    cone-rod dystrophy    leber congenital amaurosis    retinitis pigmentosa 14
    retinitis    night blindness    fundus dystrophy    retinal degeneration
    hyperopia    coloboma    nystagmus    keratoconus
    blindness    retinal disease    obesity    breast cancer
    neuronitis

    4 diseases from the University of Copenhagen DISEASES database for TULP1:
    Retinitis pigmentosa     Leber congenital amaurosis     cone-rod dystrophy     Fundus dystrophy

    6 Novoseek disease relationships for TULP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lebers congenital amaurosis 94.8 3 18432314 (1), 10440267 (1), 17962469 (1)
    retinitis pigmentosa 88.2 13 17620573 (3), 10711677 (2), 9660588 (1), 18432314 (1) (see all 7)
    retinal degeneration 83.8 14 10440267 (4), 9096357 (1), 10607826 (1), 17962469 (1) (see all 8)
    cone-rod dystrophy 79.3 1 9096357 (1)
    retinopathy 54.1 1 10674986 (1)
    obesity 8.51 1 10607826 (1)

    GeneTests: TULP1
    Leber Congenital Amaurosis

    Human Genome Epidemiology (HuGE) Navigator: TULP1 (2 documents)

    Export disorders for TULP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TULP1 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with TULP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. (PubMed id 9096357)1, 2, 3, 9 North M.A.... Nishina P.M. (1997)
    2. Novel compound heterozygous TULP1 mutations in a family with severe early-onset retinitis pigmentosa. (PubMed id 17620573)1, 2, 9 den Hollander A.I....Hoyng C.B. (2007)
    3. Novel TULP1 mutation causing leber congenital amaurosis or early onset retinal degeneration. (PubMed id 17962469)1, 2, 9 Mataftsi A....Munier F.L. (2007)
    4. Tubby-like protein-1 mutations in autosomal recessive retinitis pigmentosa. (PubMed id 9660588)1, 2, 9 Gu S....Wright A. (1998)
    5. Recessive mutations in the gene encoding the tubby-like protein TULP1 in patients with retinitis pigmentosa. (PubMed id 9462750)1, 2, 9 Hagstrom S.A.... Dryja T.P. (1998)
    6. A homozygosity-based search for mutations in patients with autosomal recessive retinitis pigmentosa, using microsatellite markers. (PubMed id 15557452)1, 2, 9 Kondo H.... Hayashi K. (2004)
    7. Identification of tubby and tubby-like protein 1 as eat-me signals by phage display. (PubMed id 19837063)1, 2 Caberoy N.B.... Li W. (2010)
    8. Tubby-like protein 1 (TULP1) interacts with F-actin in photoreceptor cells. (PubMed id 16303976)1, 2 Xi Q.... Hagstrom S.A. (2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Homozygosity and physical mapping of the autosomal re cessive retinitis pigmentosa locus (RP14) on chromosome 6p21.3. (PubMed id 9521870)1, 3 Banerjee P....Knowles J.A. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7287 HGNC: 12423 AceView: TULP1 Ensembl:ENSG00000112041 euGenes: HUgn7287
    ECgene: TULP1 H-InvDB: TULP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TULP1 Pharmacogenomics, SNPs, Pathways
    Mutations of the TULP1 genehttp://www.retina-international.org/files/sci-news/tulpmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TULP1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TULP1 gene:
    Search GeneIP for patents involving TULP1

    GeneCards and IP:
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