Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUFT1 Gene

protein-coding GIFtS: 50
GCID: GC01P151513

tuftelin 1

Explore 5 diseases affiliated with
TUFT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tuftelin 1¹ ²
Tuftelin¹

External Ids:	HGNC: 12422¹	Entrez Gene: 7286²	Ensembl: ENSG00000143367⁷	OMIM: 600087⁵	UniProtKB: Q9NNX1³

Export aliases for TUFT1 gene to outside databases

Previous GC identifers: GC01P149354 GC01P147260 GC01P148287 GC01P148729 GC01P148325 GC01P149779 GC01P122890

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1

Function: Involved in the mineralization and structural organization of enamel

Gene Wiki entry for TUFT1 (Tuftelin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TUFT1 gene promoter:
AhR RFX1 p53 Lmo2 AP-4 SREBP-1b Arnt SREBP-1a COMP1 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUFT1 promoter sequence

Search SABiosciences Chromatin IP Primers for TUFT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUFT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21

TUFT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUFT1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P151513: view genomic region (about GC identifiers)

Start:	151,512,781 bp from pter	End:	151,556,059 bp from pter
Size:	43,279 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1 (See protein sequence)

Recommended Name: Tuftelin

Size: 390 amino acids; 44264 Da

Subunit: Interacts with TFIP11 (By similarity)

Subcellular location: Secreted (By similarity). Note=Secreted at a very early stage of enamel formation, concentrated

at the dentin-enamel junction and tightly bound to the surface of the growing crystallites (By similarity)

Sequence caution: Sequence=BAB15615.1; Type=Erroneous initiation;

Secondary accessions: B2RD57 D3DV21 D3DV22 Q5T384 Q5T385 Q9BU28 Q9H5L1

Alternative splicing: 3 isoforms: Q9NNX1-1 Q9NNX1-2 Q9NNX1-3

Explore the universe of human proteins at neXtProt for TUFT1: NX_Q9NNX1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NNX1

TUFT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001119809.1 NP_064512.1

ENSEMBL proteins:

ENSP00000357842 ENSP00000376476 ENSP00000357841 ENSP00000343781 ENSP00000437997

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TUFT1 OriGene Protein Over-expression Lysate (see all 2): TUFT1 OriGene Custom Protein Services for TUFT1
	GenScript Custom Purified and Recombinant Proteins Services for TUFT1
	Novus Biologicals TUFT1 Proteins Novus Biologicals TUFT1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	12489194
GO:0005737	cytoplasm	IDA	--

TUFT1 for ontologies About GeneDecksing

TUFT1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TUFT1 OriGene Custom Antibody Services for TUFT1
	GenScript Custom Superior Antibodies Services for TUFT1
	Novus Biologicals TUFT1 Antibodies
	Search for Antibodies for TUFT1 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibodies for TUFT1

Assay Products for TUFT1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TUFT1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TUFT1 for domains About GeneDecksing

1 InterPro domain/family:

IPR024846 Tuftelin

Graphical View of Domain Structure for InterPro Entry Q9NNX1

ProtoNet protein and cluster: Q9NNX1

UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1

Similarity: Belongs to the tuftelin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TUFT1_HUMAN, Q9NNX1

Function: Involved in the mineralization and structural organization of enamel

Genatlas biochemistry entry for TUFT1:

tuftelin,acidic enamelin protein,that plays a major role in the mineralization and structural organization of enamel

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TUFT1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUFT1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TUFT1 (see all 18):
		hsa-miR-4311 hsa-miR-1321 hsa-miR-520d-5p hsa-miR-346 hsa-miR-4314 hsa-miR-9 hsa-miR-149 hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: TUFT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUFT1 (see all 7) OriGene shRNA RFP: TUFT1 OriGene siRNA: TUFT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUFT1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TUFT1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUFT1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUFT1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TUFT1 (NM_001126337)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUFT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUFT1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TUFT1
		Search LifeMap BioReagents cell lines for TUFT1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUFT1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0030345	structural constituent of tooth enamel	NAS	12489194

TUFT1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TUFT1:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TUFT1

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

5/7 Interacting proteins for TUFT1 (Q9NNX1³ ENSP00000357842⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TFIP11	Q9UBB9³	I2D: score=2
BIRC2	Q13490³	I2D: score=1
TRIM27	P14373³	I2D: score=1
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
ABCD3	ENSP00000359233⁴	STRING: ENSP00000359233

About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030282	bone mineralization	NAS	12489194
GO:0042476	odontogenesis	NAS	12489194

TUFT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TUFT1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TUFT1
1 Novoseek chemical compound relationship for TUFT1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gold	17.4	1	7626400 (1)

Search CenterWatch for drugs/clinical trials and news about TUFT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUFT1 gene (2 alternative transcripts):

NM_001126337.1 NM_020127.2

Unigene Cluster for TUFT1:

Tuftelin 1

Hs.489922 [show with all ESTs]

Unigene Representative Sequence: NM_020127

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000368849(uc001eyl.3 uc001eym.3 uc010pdf.2 uc010pdg.2)

ENST00000392712 ENST00000368848 ENST00000498606 ENST00000461859 ENST00000490156

ENST00000353024 ENST00000538902

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TUFT1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUFT1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TUFT1 (see all 18):
		hsa-miR-4311 hsa-miR-1321 hsa-miR-520d-5p hsa-miR-346 hsa-miR-4314 hsa-miR-9 hsa-miR-149 hsa-miR-186

		SwitchGear 3'UTR luciferase reporter plasmid: TUFT1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUFT1 (see all 7) OriGene shRNA RFP: TUFT1 OriGene siRNA: TUFT1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUFT1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUFT1 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUFT1 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TUFT1 (NM_001126337)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUFT1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUFT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUFT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TUFT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUFT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUFT1

Additional cDNA sequence:

AF086205.1 AF254260.1 AK026989.1 AK075001.1 AK223161.1 AK298066.1 AK299263.1 AK299925.1

AK315414.1 AL136917.1 AY358610.1 BC002933.1 BC008301.1

8 DOTS entries:

DT.95267565 DT.100776330 DT.210831 DT.91749693 DT.121361234 DT.121361244 DT.99985438 DT.40298072

24/64 AceView cDNA sequences (see all 64):

AI168826 AI458334 BU192294 BM464349 AL043356 BQ425395 BQ719901 BX504930

BQ887143 BQ958944 BC008301 AY358610 CA487739 BC002933 AL136917 BE733924

BG117276 BQ945826 AK075001 BQ072206 AI925461 AK026989 AF254260 AL603195

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TUFT1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15
SP1:			-		-				-										-
SP2:
SP3:					-		-		-
SP4:

ECgene alternative splicing isoforms for TUFT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUFT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTTCCCT

About this image
See TUFT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUFT1

SOURCE GeneReport for Unigene cluster: Hs.489922

SABiosciences Custom PCR Arrays for TUFT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUFT1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TUFT1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUFT1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUFT1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUFT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TUFT1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TUFT1¹	tuftelin 1	75.44(n) 78.07(a)		770812 XM_001234134.2 XP_001234135.2
lizard (Anolis carolinensis)	Reptilia	TUFT1⁶	--	52(a)	1 ↔ 1	GL343554.1(100397-132297)
zebrafish (Danio rerio)	Actinopterygii	tuft1a¹	tuftelin 1a	50(n) 34.92(a)		562692 NM_001080001.1 NP_001073470.1

ENSEMBL Gene Tree for TUFT1 (if available)
TreeFam Gene Tree for TUFT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TUFT1 gene

GCOM1² CCDC68²

1 SIMAP similar gene for TUFT1 using alignment to 3 protein entries: TUFT1_HUMAN (see all proteins):

GCOM1

TUFT1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150612239^1,2	C,	other	151537025(+)	`AGCTCC/TGGGAG`	4	R W	mis¹		1		NA	4552
rs75094320^1,2	C,F,	--	151510817(+)	`GAACCA/GAGGGA`	3	--	us2k¹ ut3¹		1		WA	118
rs1891595^1,2	C,F,O,H,	--	151510821(-)	`AGGGTC/GCCTTG`	3	--	us2k¹ ut3¹		11		EA NA NS	696
rs1045298^1,2	C,F,H,	--	151510825(+)	`GGACCC/TTCATT`	3	--	ut3¹ us2k¹		17		MN NA NS EA	2146
rs139245298^1,2		--	151511058(+)	`ATGTCA/GTGATT`	3	--	us2k¹ ut3¹		0	--	--	--	--
rs8934^1,2	C,F,	--	151511109(-)	`ATTGGA/GTTGGG`	3	--	us2k¹ ut3¹		11		EA MN NA WA	1992
rs114800747^1,2	F,	--	151511255(+)	`GGAGCC/TGAAGC`	3	--	us2k¹ int¹		1		NA	120
rs3811411^1,2	C,F,A,H,	--	151511268(+)	`GAGTTG/TTCTTC`	3	--	int¹ us2k¹		32		EA NA NS WA	3564
rs16833373^1,2	C,F,H,	--	151511280(+)	`CCTGAC/TTTTTC`	3	--	int¹ us2k¹		10		NA NS EA CSA WA	684
rs116648533^1,2	F,	--	151511290(+)	`CAGAGG/CCCCTT`	3	--	us2k¹ int¹		1		WA	118

HapMap Linkage Disequilibrium report for TUFT1 (151512781 - 151556059 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TUFT1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUFT1

DNA2.0 Custom Variant and Variant Library Synthesis for TUFT1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TUFT1 for disorders           About GeneDecksing

OMIM gene information: 600087    OMIM disorders: --

5 diseases for TUFT1:    About MalaCards

amelogenesis imperfecta dental caries periodontitis hypoxia

neuronitis

1 disease from the University of Copenhagen DISEASES database for TUFT1:

Amelogenesis imperfecta

2 Novoseek disease relationships for TUFT1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
amelogenesis imperfecta	92.4	3	7554940 (1), 9189626 (1), 9189622 (1)
genetic disorder	46.1	1	7554940 (1)

Human Genome Epidemiology (HuGE) Navigator: TUFT1 (1 document)

Export disorders for TUFT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TUFT1 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with TUFT1)

Utopia: connect your pdf to the dynamic
world of online information

Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization. (PubMed id 7919663)^{1, 2, 3, 9} Deutsch D.... Fisher L.W. (1994)
The human tuftelin gene: cloning and characterization. (PubMed id 11733143)^{1, 2, 9} Mao Z.... Deutsch D. (2001)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues. (PubMed id 12489194)^{1, 9} Deutsch D....Mao Z. (2002)
Enamel formation genes are associated with high caries experience in Turkish children. (PubMed id 18781068)^{1, 9} Patir A....Vieira A.R. (2008)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7286	HGNC: 12422	AceView: TUFT1	Ensembl:ENSG00000143367	euGenes: HUgn7286
ECgene: TUFT1	H-InvDB: TUFT1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TUFT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUFT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TUFT1 gene:
Search GeneIP for patents involving TUFT1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TUFT1		OriGene shRNA RFP for TUFT1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUFT1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUFT1
	OriGene Protein Over-expression Lysate for TUFT1		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TUFT1		OriGene 3'-UTR Clone for TUFT1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUFT1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUFT1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TUFT1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TUFT1		OriGene Custom Protein Services for TUFT1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUFT1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUFT1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUFT1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUFT1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUFT1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUFT1

	GenScript Custom Purified and Recombinant Proteins Services for TUFT1		GenScript cDNA clones with any tag delivered in your preferred vector for TUFT1
	GenScript Custom Assay Services for TUFT1		GenScript Custom Superior Antibodies Services for TUFT1
	GenScript Custom overexpressing Cell Line Services for TUFT1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TUFT1 promoter
	Search Chromatin IP Primers for TUFT1
	RT² qPCR Primer Assay in human, mouse, rat TUFT1
	Search GNC Networks for TUFT1
	SABiosciences Custom PCR Arrays for TUFT1

Search Tocris compounds for TUFT1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TUFT1 antibodies
	TUFT1 proteins
	TUFT1 lysates

	Search for Antibodies for TUFT1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TUFT1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for TUFT1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUFT1

	SwitchGear 3'UTR luciferase reporter plasmids for TUFT1
	SwitchGear Promoter luciferase reporter plasmids for TUFT1

ThermoFisher Antibodies for TUFT1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUFT1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TUFT1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TUFT1 Gene

tuftelin 1

Aliases
for TUFT1 gene

Summaries
for TUFT1 gene

Genomic Views
for TUFT1 gene

Proteins
for TUFT1 gene

Protein Domains /
Families
for TUFT1 gene

Function
for TUFT1 gene

Pathways & Interactions
for TUFT1 gene

Drugs & Compounds
for TUFT1 gene

Transcripts
for TUFT1 gene

Expression
for TUFT1 gene

Orthologs
for TUFT1 gene

Paralogs
for TUFT1 gene

Genomic Variants
for TUFT1 gene

Disorders / Diseases
for TUFT1 gene

Publications
for TUFT1 gene

External Searches for TUFT1 gene

Genome Databases showing TUFT1 gene

Other Databases showing TUFT1 gene

Specialized Databases showing TUFT1 gene

Intellectual Property
for TUFT1 gene

Products
for TUFT1 gene

View Random Gene

Advanced Search

Export list of displayed genes

TUFT1 Gene

tuftelin 1

Aliasesfor TUFT1 gene

Summariesfor TUFT1 gene

Genomic Viewsfor TUFT1 gene

Proteinsfor TUFT1 gene

Protein Domains /Familiesfor TUFT1 gene

Functionfor TUFT1 gene

Pathways & Interactionsfor TUFT1 gene

Drugs & Compoundsfor TUFT1 gene

Transcriptsfor TUFT1 gene

Expression for TUFT1 gene

Orthologsfor TUFT1 gene

Paralogsfor TUFT1 gene

Genomic Variantsfor TUFT1 gene

Disorders / Diseasesfor TUFT1 gene

Publicationsfor TUFT1 gene

External Searches for TUFT1 gene

Genome Databases showing TUFT1 gene

Other Databases showing TUFT1 gene

Specialized Databases showing TUFT1 gene

Intellectual Propertyfor TUFT1 gene

Productsfor TUFT1 gene

View Random Gene

Aliases
for TUFT1 gene

Summaries
for TUFT1 gene

Genomic Views
for TUFT1 gene

Proteins
for TUFT1 gene

Protein Domains /
Families
for TUFT1 gene

Function
for TUFT1 gene

Pathways & Interactions
for TUFT1 gene

Drugs & Compounds
for TUFT1 gene

Transcripts
for TUFT1 gene

Expression
for TUFT1 gene

Orthologs
for TUFT1 gene

Paralogs
for TUFT1 gene

Genomic Variants
for TUFT1 gene

Disorders / Diseases
for TUFT1 gene

Publications
for TUFT1 gene

Intellectual Property
for TUFT1 gene

Products
for TUFT1 gene