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TUFM Gene

protein-coding   GIFtS: 61
GCID: GC16M028853

Tu Translation Elongation Factor, Mitochondrial

  See TUFM-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tu Translation Elongation Factor, Mitochondrial1 2     EFTU2 5
EF-Tu2 3     EF-TuMT2
P432 3     Elongation Factor Tu, Mitochondrial2
COXPD42 5     

External Ids:    HGNC: 124201   Entrez Gene: 72842   Ensembl: ENSG000001789527   OMIM: 6023895   UniProtKB: P494113   

Export aliases for TUFM gene to outside databases

Previous GC identifers: GC16U990059 GC16M029177 GC16M028851 GC16M028891 GC16M028761 GC16M026721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TUFM Gene:
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have
been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal
encephalopathy. A pseudogene has been identified on chromosome 17. (provided by RefSeq, Jul 2008)

GeneCards Summary for TUFM Gene:
TUFM (Tu translation elongation factor, mitochondrial) is a protein-coding gene. Diseases associated with TUFM include combined oxidative phosphorylation deficiency 4, and lactic acidosis. GO annotations related to this gene include GTP binding and translation elongation factor activity. An important paralog of this gene is EEFSEC.

UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during
protein biosynthesis

Gene Wiki entry for TUFM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUFM gene promoter:
         Pax-2   Pax-2a   AP-4   CUTL1   PPAR-gamma1   PPAR-gamma2   ATF6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUFM promoter sequence
   Search Chromatin IP Primers for TUFM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUFM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TUFM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUFM gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028853:  view genomic region     (about GC identifiers)

Start:
28,853,732 bp from pter      End:
28,857,729 bp from pter
Size:
3,998 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411 (See protein sequence)
Recommended Name: Elongation factor Tu, mitochondrial precursor  
Size: 452 amino acids; 49542 Da
Sequence caution: Sequence=AAC60647.1; Type=Erroneous initiation; Sequence=AAH01633.2; Type=Erroneous initiation;
Sequence=AAH10041.2; Type=Erroneous initiation;
Secondary accessions: O15276

Explore the universe of human proteins at neXtProt for TUFM: NX_P49411

Explore proteomics data for TUFM at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys79, Lys88, Lys238, Lys256, Lys311
  • Modification sites at PhosphoSitePlus

  • See TUFM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003312.3  
    ENSEMBL proteins: 
     ENSP00000322439   ENSP00000455007  

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for TUFM (16 products) 

     
    antibodies-online peptides for TUFM

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR004541 Transl_elong_EFTu/EF1A_bac/org
     IPR000795 EF_GTP-bd_dom
     IPR004160 Transl_elong_EFTu/EF1A_C
     IPR004161 Transl_elong_EFTu/EF1A_2
     IPR009000 Transl_B-barrel

    Graphical View of Domain Structure for InterPro Entry P49411

    ProtoNet protein and cluster: P49411

    1 Blocks protein domain: IPB004160 Elongation factor Tu

    UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411
    Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily


    Find genes that share domains with TUFM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFTU_HUMAN, P49411
    Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during
    protein biosynthesis

         Genatlas biochemistry entry for TUFM:
    mitochondrial elongation factor EF-Tu

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003746translation elongation factor activity IDA9332382
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with TUFM           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TUFM

    miRNA
    Products:
        
    miRTarBase miRNAs that target TUFM:
    hsa-mir-92a-3p (MIRT049214), hsa-mir-1260b (MIRT052711), hsa-mir-324-5p (MIRT043186), hsa-mir-339-5p (MIRT042804), hsa-mir-186-5p (MIRT045200), hsa-mir-28-5p (MIRT050010), hsa-mir-615-3p (MIRT039619)

    Block miRNA regulation of human, mouse, rat TUFM using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TUFM:
    hsa-miR-515-5p hsa-miR-519e* hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUFM 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EFTU_HUMAN, P49411: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IDA--
    GO:0042645mitochondrial nucleoid IDA18063578
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with TUFM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUFM
    Interactions:

        GeneGlobe Interaction Network for TUFM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUFM (P494112, 3 ENSP000003224394) via UniProtKB, MINT, STRING, and/or I2D (see all 928)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNFRSF1BP203332, 3MINT-49418 I2D: score=2 
    BRIX1Q8TDN62, 3MINT-7945693 I2D: score=1 
    EEF1A1P681042, 3MINT-7945693 I2D: score=1 
    EIF2S3P410912, 3MINT-7945693 I2D: score=1 
    GTPBP4Q9BZE42, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006414translational elongation IDA9332382

    Find genes that share ontologies with TUFM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TUFM (EFTU)

    4 HMDB Compounds for TUFM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for TUFM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    7 Novoseek inferred chemical compound relationships for TUFM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 81.6 3 1573997 (1), 17130126 (1), 17804641 (1)
    gdp 52.7 2 2207145 (1), 8765000 (1)
    trna 48.1 1 16987107 (1)
    gtp 46.5 2 8075071 (1), 8749358 (1)
    glycerol 17.6 7 14623179 (4)
    leucine 15.7 2 12729910 (1)
    magnesium 9.69 1 8765000 (1)



    Find genes that share compounds with TUFM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUFM gene: 
    NM_003321.4  

    Unigene Cluster for TUFM:

    Tu translation elongation factor, mitochondrial
    Hs.12084  [show with all ESTs]
    Unigene Representative Sequence: NM_003321
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313511(uc002drh.2) ENST00000569217 ENST00000565012 ENST00000561644

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TUFM:
    hsa-miR-515-5p hsa-miR-519e* hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUFM 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TUFM
    Predesigned siRNA for gene silencing in human, mouse, rat TUFM
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    OriGene qSTAR qPCR primer pairs in human, mouse for TUFM
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TUFM
      QuantiTect SYBR Green Assays in human, mouse, rat TUFM
      QuantiFast Probe-based Assays in human, mouse, rat TUFM

    Additional mRNA sequence: 

    BC001633.1 BC010041.2 L38995.1 S75463.1 X84694.1 

    Selected DOTS entries (see all 33):

    DT.102843682  DT.95316969  DT.99992319  DT.40314238  DT.100887032  DT.91865386  DT.120696948  DT.97867088 
    DT.120698145  DT.100887018  DT.100887041  DT.100887035  DT.120697236  DT.91943661  DT.120695443  DT.97862347 
    DT.102843715  DT.100887039  DT.87017312  DT.92005964  DT.120695409  DT.100887036  DT.97849808  DT.99991591 

    Selected AceView cDNA sequences (see all 908):

    AW574771 BM759784 BU856718 CN485026 BX481939 BM770553 BG675740 BU170090 
    BM982613 AW406807 BX364717 BI861052 BQ652297 BM756853 BQ181973 BE563305 
    BC010041 CR621980 CA412290 BU153999 BU184848 BE789134 BQ923683 BQ943178 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUFM (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                                                                      -                           
    SP2:                          -     -                                                                                 
    SP3:                                                              -                                                   
    SP4:                                            -     -                                                               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for TUFM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUFM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATAGGCTG
    TUFM Expression
    About this image


    TUFM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TUFM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUFM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.12084
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUFM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUFM gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tufm1 , 5 Tu translation elongation factor, mitochondrial1, 5 87.73(n)1
    93.79(a)1
      7 (69.08 cM)5
    2338701  NM_172745.31  NP_766333.11 
     1264873555 
    lizard
    (Anolis carolinensis)
    Reptilia TUFM6
    Tu translation elongation factor, mitochondrial
    76(a)
    1 ↔ 1
    GL343287.1(394218-400780)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59612 Xenopus laevis transcribed sequence with moderate similarity more 77.07(n)    CA791534.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tufm1 Tu translation elongation factor, mitochondrial 69.1(n)
    76.16(a)
      541378  NM_001013505.2  NP_001013523.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EfTuM1 , 3 translational elongation translation
    elongation more3
    Elongation factor Tu mitochondrial1
    71(a)
    (best of 2)3
    68.84(n)1
    67.42(a)1
      50A143
    444381  NM_001169673.11  NP_001163144.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.233
    tufm-11
    tufm-11 55(a)
    (best of 2)3
    58.33(n)1
    58.09(a)1
      III(2884141-2886755)3
    1753981  NM_065222.41  NP_497623.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUF1(YOR187W)4
    TUF11
    Mitochondrial translation elongation factor Tu; comprises more4
    TUF11
    59.23(n)1
    62.82(a)1
      15(684030-685343)4
    8543591, 4  NP_014830.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G029301 AT4G02930 58.91(n)
    57.29(a)
      828134  NM_116527.3  NP_192202.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109872 Oryza sativa elongation factor Tu (tufM) mRNA, complete more 75.66(n)    AK102069.1 


    ENSEMBL Gene Tree for TUFM (if available)
    TreeFam Gene Tree for TUFM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUFM gene
    EEFSEC2  

    Find genes that share paralogs with TUFM           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TUFM
    PGOHUM00000236995


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for TUFM    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
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    ----------
    VAR_0319024
    Combined oxidative phosphorylation deficiency 4 (COXPD4)4--see VAR_0319022 R Q mis40--------
    rs349504431,2
    ----26726697(+) CCATC-/TTTTTT 1 -- us2k10--------
    rs3733034341,2
    ----28853391(+) AATCC-/CAGCAG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TUFM (28853732 - 28857729 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TUFM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518648CNV Loss19592680
    nsv905700CNV Loss21882294
    nsv905701CNV Loss21882294
    nsv519100CNV Gain19592680
    nsv905698CNV Gain21882294
    nsv905702CNV Gain+Loss21882294
    dgv842e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): TUFM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUFM
    DNA2.0 Custom Variant and Variant Library Synthesis for TUFM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602389   
    OMIM disorders: 610678  
    UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411
  • Combined oxidative phosphorylation deficiency 4 (COXPD4) [MIM:610678]: A mitochondrial disease resulting
    in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein
    synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 2 diseases for TUFM:    
    About MalaCards
    combined oxidative phosphorylation deficiency 4    lactic acidosis


    Find genes that share disorders with TUFM           About GenesLikeMe

    Genetic Association Database (GAD): TUFM
    Human Genome Epidemiology (HuGE) Navigator: TUFM (1 document)

    Export disorders for TUFM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TUFM gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with TUFM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human mitochondrial elongation factor Tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene. (PubMed id 9332382)1, 2, 3, 9 Ling M....Robinson B.H. (Gene 1997)
    2. A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues. (PubMed id 7828719)1, 2, 9 Wells J.... Koshy R. (FEBS Lett. 1995)
    3. Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. (PubMed id 9545647)1, 3, 9 Shah Z.H....Jacobs H.T. (Genomics 1998)
    4. Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. (PubMed id 17160893)1, 2, 9 Valente L....Zeviani M. (Am. J. Hum. Genet. 2007)
    5. Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu. (PubMed id 8547323)1, 2, 9 Woriax V.L.... Spremulli L.L. (Biochim. Biophys. Acta 1995)
    6. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    9. The R336Q mutation in human mitochondrial EFTu prevents the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex. (PubMed id 19524667)1, 9 Valente L....Zeviani M. (Biochim. Biophys. Acta 2009)
    10. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 7284 HGNC: 12420 AceView: TUFM Ensembl:ENSG00000178952 euGenes: HUgn7284
    ECgene: TUFM H-InvDB: TUFM

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TUFM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TUFM gene:
    Search GeneIP for patents involving TUFM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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