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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUFM Gene

protein-coding   GIFtS: 56
GCID: GC16M028853

Tu translation elongation factor, mitochondrial

 Explore 13 diseases affiliated with
TUFM via our new
 Human Malady Compendium 
Biological research products
for TUFM
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tu Translation Elongation Factor, Mitochondrial1 2     P432 3
EFTU1 2 5     COXPD42 5
EF-TuMT1 2     EFTu1
EF-Tu2 3     Elongation Factor Tu, Mitochondrial2

External Ids:    HGNC: 124201   Entrez Gene: 72842   Ensembl: ENSG000001789527   OMIM: 6023895   UniProtKB: P494113   

Export aliases for TUFM gene to outside databases

Previous GC identifers: GC16U990059 GC16M029177 GC16M028851 GC16M028891 GC16M028761 GC16M026721


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUFM:
This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been
associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A
pseudogene has been identified on chromosome 17. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411
Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein
biosynthesis

Gene Wiki entry for TUFM


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUFM gene promoter:
         Pax-2   Pax-2a   AP-4   CUTL1   PPAR-gamma1   PPAR-gamma2   ATF6   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUFM promoter sequence
   Search SABiosciences Chromatin IP Primers for TUFM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUFM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TUFM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUFM gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M028853:  view genomic region     (about GC identifiers)

Start:
28,853,732 bp from pter      End:
28,857,729 bp from pter
Size:
3,998 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411 (See protein sequence)
Recommended Name: Elongation factor Tu, mitochondrial precursor  
Size: 452 amino acids; 49542 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAC60647.1; Type=Erroneous initiation; Sequence=AAH01633.2; Type=Erroneous initiation;
Sequence=AAH10041.2; Type=Erroneous initiation;
Secondary accessions: O15276

Explore the universe of human proteins at neXtProt for TUFM: NX_P49411

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P49411

  • TUFM Protein expression data from MOPED and PaxDb:    About this image 
    TUFM Protein Expression
    REFSEQ proteins: NP_003312.3  
    ENSEMBL proteins: 
     ENSP00000322439   ENSP00000455007  

    Human Recombinant Protein Products for TUFM: 
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TUFM

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IDA--
    GO:0042645mitochondrial nucleoid IDA18063578

    TUFM for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TUFM for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR004541 Transl_elong_EFTu/EF1A_bac/org
     IPR009001 Transl_elong_EF1A/Init_IF2_C
     IPR000795 EF_GTP-bd_dom
     IPR004160 Transl_elong_EFTu/EF1A_C
     IPR004161 Transl_elong_EFTu/EF1A_2

    Graphical View of Domain Structure for InterPro Entry P49411

    ProtoNet protein and cluster: P49411

    1 Blocks protein family: IPB004160 Elongation factor Tu

    UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411
    Similarity: Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EFTU_HUMAN, P49411
    Function: This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein
    biosynthesis

         Genatlas biochemistry entry for TUFM:
    mitochondrial elongation factor EF-Tu

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003746translation elongation factor activity IDA9332382
    GO:0003924GTPase activity IEA--
    GO:0005525GTP binding IEA--
         
    TUFM for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TUFM 

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUFM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/757 Interacting proteins for TUFM (P494112, 3 ENSP000003224394) via UniProtKB, MINT, STRING, and/or I2D (see all 757)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GCN1L1Q926162, 3, ENSP000003006484MINT-7945693 I2D: score=1 STRING: ENSP00000300648
    TNFRSF1BP203332, 3MINT-49418 I2D: score=2 
    ATRQ135352, 3MINT-7945693 I2D: score=1 
    BRIX1Q8TDN62, 3MINT-7945693 I2D: score=1 
    EEF1A1P681042, 3MINT-7945693 I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006414translational elongation IDA9332382

    TUFM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TUFM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TUFM

    4 HMDB Compounds for TUFM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    1 DrugBank Compound for TUFM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--17139284 17016423 10592235

    7 Novoseek chemical compound relationships for TUFM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aminoacyl-trna 81.6 3 1573997 (1), 17130126 (1), 17804641 (1)
    gdp 52.7 2 2207145 (1), 8765000 (1)
    trna 48.1 1 16987107 (1)
    gtp 46.5 2 8075071 (1), 8749358 (1)
    glycerol 17.6 7 14623179 (4)
    leucine 15.7 2 12729910 (1)
    magnesium 9.69 1 8765000 (1)

    Search CenterWatch for drugs/clinical trials and news about TUFM / EFTU 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUFM gene: 
    NM_003321.4  

    Unigene Cluster for TUFM:

    Tu translation elongation factor, mitochondrial
    Hs.12084  [show with all ESTs]
    Unigene Representative Sequence: NM_003321
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000313511(uc002drh.2) ENST00000569217 ENST00000565012 ENST00000561644


    miRNA
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    hsa-miR-515-5p hsa-miR-519e* hsa-miR-3160-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUFM 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUFM (see all 7)
    OriGene shRNA RFP: TUFM
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    Sirion Biotech Custom design and validation of potent shRNA sequences against TUFM 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUFM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUFM

    Additional cDNA sequence: 

    BC001633.1 BC010041.2 L38995.1 S75463.1 X84694.1 

    24/33 DOTS entries (see all 33):

    DT.102843682  DT.95316969  DT.99992319  DT.40314238  DT.100887032  DT.91865386  DT.120696948  DT.97867088 
    DT.120698145  DT.100887018  DT.100887041  DT.100887035  DT.120697236  DT.91943661  DT.120695443  DT.97862347 
    DT.102843715  DT.100887039  DT.87017312  DT.92005964  DT.120695409  DT.100887036  DT.97849808  DT.99991591 

    24/908 AceView cDNA sequences (see all 908):

    CA445346 CR621980 CA445378 BE732851 BM757062 AI423684 BM758862 BQ648284 
    BQ897019 BU174046 BU196722 BQ949984 BQ673011 BU168972 BM848543 CN485340 
    BQ437960 BU687615 BQ645577 BU170090 BU539598 BM757115 BM747053 BQ219050 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TUFM (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                                                                                      -                           
    SP2:                          -     -                                                                                 
    SP3:                                                              -                                                   
    SP4:                                            -     -                                                               
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for TUFM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUFM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCATAGGCTG
    TUFM Expression
    About this image
    See TUFM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUFM

    SOURCE GeneReport for Unigene cluster: Hs.12084
        SABiosciences Custom PCR Arrays for TUFM

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUFM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for TUFM gene from 10/44 species (see all 44)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves EIF2S36
    eukaryotic translation initiation factor 2, subuni...
    21(a)
    possible ortholog
    1(121677562-121690591)
    lizard
    (Anolis carolinensis)
    Reptilia TUFM6
    --
    --
    82(a)
    21(a)
    1 ↔ 1
    possible ortholog
    GL343287.1(396340-401505)
    3(125778121-125790504)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59612 Xenopus laevis transcribed sequence with moderate similarity more 77.07(n)    CA791534.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tufm1 Tu translation elongation factor, mitochondrial 67.26(n)
    73.09(a)
      541378  NM_001013505.1  NP_001013523.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EfTuM1 , 3 translational elongation translation
    elongation more3
    Elongation factor Tu mitochondrial1
    71(a)
    (best of 2)3
    66.07(n)1
    62.92(a)1
      50A143
    444381  NM_001169673.11  NP_001163144.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y71H2AM.233
    tufm-11
    Protein TUFM-11 55(a)
    (best of 2)3
    58.19(n)1
    57.21(a)1
      III(2884141-2886755)3
    1753981  NM_065222.31  NP_497623.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUF1(YOR187W)4
    TUF11
    Mitochondrial translation elongation factor Tu; comprises more4
    Tuf1p1
    59.36(n)1
    63.14(a)1
      15(684030-685343)4
    8543591, 4  NP_014830.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G029301 Elongation factor Tu 58.91(n)
    57.29(a)
      828134  NM_116527.3  NP_192202.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109872 Oryza sativa elongation factor Tu (tufM) mRNA, complete more 75.66(n)    AK102069.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria tufA6
    tufB6
    protein chain elongation factor EF-Tu (duplicate o...
    protein chain elongation factor EF-Tu (duplicate o...
    56(a)
    56(a)
    possible ortholog
    possible ortholog
    Chromosome(3468167-3469351)
    Chromosome(4173967-4175151)


    ENSEMBL Gene Tree for TUFM (if available)
    TreeFam Gene Tree for TUFM (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUFM gene
    EEFSEC2  

    TUFM for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TUFM
    PGOHUM00000236995


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/119 NCBI SNPs in TUFM are shown (see all 119    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735295091,2
    C--26720827(+) ACATAT/CAACAC 1 -- ds50012Minor allele frequency- C:0.04WA 120
    rs118608271,2
    C,F,H--26721100(+) GAAAAT/CTGCCA 1 -- ds50016Minor allele frequency- C:0.08NS EA CSA WA 496
    rs133320381,2
    C,F,H--26721140(+) gtcatT/Cggcta 1 -- ds50015Minor allele frequency- C:0.01NS EA WA 528
    rs760816341,2
    F--26722111(+) AGGTTA/GAGAGT 1 -- int11Minor allele frequency- G:0.03NA 120
    rs115422601,2
    C--26724341(-) GGTGGA/C/GGCTAA 3 G syn11NA 4550
    rs1156398681,2
    C,F--26724436(+) TGAACC/TCTCCC 1 -- int11Minor allele frequency- T:0.08WA 118
    rs1120297651,2
    C--26725281(+) GCCGCC/TAGTGT 1 -- ut512Minor allele frequency- T:0.06CSA WA 120
    rs779896291,2
    F--26725976(+) GTAGTC/ACCTCA 1 -- us2k11Minor allele frequency- A:0.22WA 118
    rs118669841,2
    C,F,H--26726476(+) gaggaC/Tggttt 1 -- us2k11Minor allele frequency- T:0.50NA 4
    rs125972691,2
    H--26726854(+) gcatgG/Tgccac 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TUFM (28853732 - 28857729 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TUFM
         1 CNV: 3999
    Human Gene Mutation Database (HGMD): TUFM

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TUFM for disorders           About GeneDecksing

    OMIM gene information: 602389   
    OMIM disorders: 610678  
    UniProtKB/Swiss-Prot: EFTU_HUMAN, P49411
  • Defects in TUFM are the cause of combined oxidative phosphorylation deficiency type 4 (COXPD4) [MIM:610678].
  • COXPD4 is characterized by neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased
    mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes

    13 diseases for TUFM:    About MalaCards
    combined oxidative phosphorylation deficiency    lactic acidosis    combined oxidative phosphorylation deficiency 4    age related macular degeneration
    treacher collins syndrome    macular degeneration    breast cancer    pneumonia
    retinitis    tuberculosis    pancreatitis    malaria
    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: TUFM (1 document)

    Export disorders for TUFM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUFM gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with TUFM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human mitochondrial elongation factor Tu (EF-Tu) gene: cDNA sequence, genomic localization, genomic structure, and identification of a pseudogene. (PubMed id 9332382)1, 2, 3, 9 Ling M....Robinson B.H. (1997)
    2. A mitochondrial elongation factor-like protein is over-expressed in tumours and differentially expressed in normal tissues. (PubMed id 7828719)1, 2, 9 Wells J.... Koshy R. (1995)
    3. Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. (PubMed id 9545647)1, 3, 9 Shah Z.H....Jacobs H.T. (1998)
    4. Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu. (PubMed id 17160893)1, 2, 9 Valente L....Zeviani M. (2007)
    5. Cloning, sequence analysis and expression of mammalian mitochondrial protein synthesis elongation factor Tu. (PubMed id 8547323)1, 2, 9 Woriax V.L.... Spremulli L.L. (1995)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    8. The R336Q mutation in human mitochondrial EFTu preven ts the formation of an active mt-EFTu.GTP.aa-tRNA ternary complex. (PubMed id 19524667)1, 9 Valente L....Zeviani M. (2009)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7284 HGNC: 12420 AceView: TUFM Ensembl:ENSG00000178952 euGenes: HUgn7284
    ECgene: TUFM H-InvDB: TUFM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUFM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUFM gene:
    Search GeneIP for patents involving TUFM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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