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TUBGCP6 Gene

protein-coding   GIFtS: 55
GCID: GC22M050656

Tubulin, Gamma Complex Associated Protein 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Gamma Complex Associated Protein 61 2     MCPHCR2 5
GCP62 3 5     KIAA16693 5
Gamma-Tubulin Complex Component 61 2     MCCRP2
GCP-62 3     

External Ids:    HGNC: 181271   Entrez Gene: 853782   Ensembl: ENSG000001281597   OMIM: 6100535   UniProtKB: Q96RT73   

Export aliases for TUBGCP6 gene to outside databases

Previous GC identifers: GC22M047207 GC22M048838 GC22M048958 GC22M048998 GC22M033553


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TUBGCP6 Gene:
The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at
the centrosome. (provided by RefSeq, Jul 2008)

GeneCards Summary for TUBGCP6 Gene:
TUBGCP6 (tubulin, gamma complex associated protein 6) is a protein-coding gene. Diseases associated with TUBGCP6 include microcephaly and chorioretinopathy with or without mental retardation, and retinopathy of prematurity. GO annotations related to this gene include microtubule binding. An important paralog of this gene is TUBGCP5.

UniProtKB/Swiss-Prot: GCP6_HUMAN, Q96RT7
Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Wiki entry for TUBGCP6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000022.11  NT_011526.8  NC_018933.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBGCP6 gene promoter:
         USF1   Pax-2   USF-1:USF-2   Pax-2a   CUTL1   NF-kappaB   USF-1   STAT3   NF-kappaB1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBGCP6 promoter sequence
   Search Chromatin IP Primers for TUBGCP6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBGCP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31-q13.33   Ensembl cytogenetic band:  22q13.33   HGNC cytogenetic band: 22q13.31-q13.33

TUBGCP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBGCP6 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22M050656:  view genomic region     (about GC identifiers)

Start:
50,656,118 bp from pter      End:
50,683,421 bp from pter
Size:
27,304 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GCP6_HUMAN, Q96RT7 (See protein sequence)
Recommended Name: Gamma-tubulin complex component 6  
Size: 1819 amino acids; 200498 Da
Subunit: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6
Sequence caution: Sequence=AAH42165.1; Type=Frameshift; Positions=1651, 1723; Sequence=BAB33339.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q5JZ80 Q6PJ40 Q86YE9 Q9BY91 Q9UGX3 Q9UGX4
Alternative splicing: 3 isoforms:  Q96RT7-1   Q96RT7-2   Q96RT7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TUBGCP6: NX_Q96RT7

Explore proteomics data for TUBGCP6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TUBGCP6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065194.2  
    ENSEMBL proteins: 
     ENSP00000248846   ENSP00000405979   ENSP00000409650   ENSP00000397387  
    Reactome Protein details: Q96RT7

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007259 TUBGCP

    Graphical View of Domain Structure for InterPro Entry Q96RT7

    ProtoNet protein and cluster: Q96RT7

    1 Blocks protein domain: IPB007259 Spc97/Spc98

    UniProtKB/Swiss-Prot: GCP6_HUMAN, Q96RT7
    Similarity: Belongs to the TUBGCP family


    TUBGCP6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCP6_HUMAN, Q96RT7
    Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008017microtubule binding IDA11694571
         
    TUBGCP6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TUBGCP6:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBGCP6
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    miRTarBase miRNAs that target TUBGCP6:
    hsa-mir-335-5p (MIRT016913), hsa-mir-324-5p (MIRT043114), hsa-mir-193b-3p (MIRT041292)

    Block miRNA regulation of human, mouse, rat TUBGCP6 using miScript Target Protectors
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GCP6_HUMAN, Q96RT7: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005813centrosome IDA--
    GO:0005815microtubule organizing center ----
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--

    TUBGCP6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBGCP6 About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Mitotic G2-G2/M phases0.69
    Centrosome maturation0.86
    Recruitment of NuMA to mitotic centrosomes0.00
    G2/M Transition0.70
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    4G-Beta Gamma Signaling
    Hedgehog Signaling in Mammals0.32
    5CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBGCP6
        14-3-3 Induced Intracellular Signaling
    Hedgehog Signaling in Mammals
    Parkinson's Disease Pathway

    2 Reactome Pathways for TUBGCP6
        Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes



    TUBGCP6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBGCP6
    Interactions:

        Search GeneGlobe Interaction Network for TUBGCP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBGCP6 (Q96RT73 ENSP000002488464) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MKNK2Q9HBH93I2D: score=2 
    N4BP2L2ENSP000002670684STRING: ENSP00000382328 STRING: ENSP00000267068
    MZT1ENSP000003670494STRING: ENSP00000367049
    MZT2BENSP000002818714STRING: ENSP00000281871
    TUBG1ENSP000002514134STRING: ENSP00000251413
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization ----
    GO:0000278mitotic cell cycle TAS--
    GO:0007020microtubule nucleation IDA11694571

    TUBGCP6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TUBGCP6 (GCP6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TUBGCP6 gene (2 alternative transcripts): 
    NM_020461.3  NM_001008658.1  

    Unigene Cluster for TUBGCP6:

    Tubulin, gamma complex associated protein 6
    Hs.336431  [show with all ESTs]
    Unigene Representative Sequence: BC151209
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248846(uc003bka.1) ENST00000498611(uc010hau.1) ENST00000425018
    ENST00000491449(uc010hat.1) ENST00000489511 ENST00000473946(uc003bkd.1)
    ENST00000434349 ENST00000439308(uc003bkb.1 uc010har.1 uc010has.1)

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      QuantiTect SYBR Green Assays in human, mouse, rat TUBGCP6
      QuantiFast Probe-based Assays in human, mouse, rat TUBGCP6

    Additional mRNA sequence: 

    AF272887.1 AK000636.1 AK310419.1 AL137665.1 AL832617.2 BC004127.2 BC023573.2 BC042165.1 
    BC113849.1 BC114457.1 BC127614.1 BC144488.1 BC144489.1 BC150613.1 BC151209.1 

    9 DOTS entries:

    DT.100817862  DT.443305  DT.101982877  DT.92409235  DT.100817866  DT.100817867  DT.100817868  DT.91758989 
    DT.100817865 

    Selected AceView cDNA sequences (see all 131):

    AF272887 C01070 CK819165 AB051456 BQ128366 NM_020461 BM713920 BU630055 
    BM678813 BC042165 AI354393 BC004127 BQ683407 BU584930 BC023573 CB305583 
    BQ678789 CD630215 BM676536 AI909927 CA426242 BI913283 BM549635 BE890177 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP6 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                -                           
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b · 24c ^ 25a · 25b · 25c ^ 26
    SP1:                                      -                           
    SP2:                                            -     -               
    SP3:                                                                  
    SP4:                                      -                           
    SP5:                          -           -     -                     


    ECgene alternative splicing isoforms for TUBGCP6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBGCP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGCAGTCCT
    TUBGCP6 Expression
    About this image

    TUBGCP6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBGCP6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.336431
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TUBGCP6 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubgcp61 , 5 tubulin, gamma complex associated protein 61, 5 78.34(n)1
    77.7(a)1
      15 (44.61 cM)5
    3285801  NM_001163319.11  NP_001156791.11 
     890983575 
    chicken
    (Gallus gallus)
    Aves TUBGCP61 tubulin, gamma complex associated protein 6 67.03(n)
    70.21(a)
      769701  XM_001232990.3  XP_001232991.3 
    lizard
    (Anolis carolinensis)
    Reptilia TUBGCP66
    tubulin, gamma complex associated protein 6
    60(a)
    1 ↔ 1
    5(64039579-64076520)
    African clawed frog
    (Xenopus laevis)
    Amphibia grip2102 gamma tubulin ring protein 71.91(n)    AJ291606.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.151072 Transcribed sequence with weak similarity to protein more 82.85(n)    BM182344.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Grip1636
    Grip163
    17(a)
    1 → many
    3L(11986374-11991238)


    ENSEMBL Gene Tree for TUBGCP6 (if available)
    TreeFam Gene Tree for TUBGCP6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBGCP6 gene
    TUBGCP52  

    TUBGCP6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBGCP6 (see all 1310)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445716511,2
    Cuntested134605195(+) TGAGCA/GATTAA 2 I syn10--------
    rs2014236191,2
    --34597839(+) TGATCC/TTCCAG 1 -- ds50010--------
    rs3717729681,2
    C--34597848(+) AGGTGC/TGGCGG 1 -- ds50010--------
    rs2006757631,2
    C--34597880(+) CCTTAC/TCACTG 1 -- ds50010--------
    rs22728521,2
    C,F,H--34597887(+) ACTGCG/AAGGCG 1 -- ds500113Minor allele frequency- A:0.05EA NS EU 3383
    rs170132381,2
    C,F,H--34597911(+) ACGCCG/AAGGCC 1 -- ds500110Minor allele frequency- A:0.04NA NS EA WA EU 1139
    rs96171181,2
    C--34597919(+) GCCACA/GGAAGC 1 -- ds50010--------
    rs1445050701,2
    C,F--34597933(+) CGGGGC/TGGACG 1 -- ds50011Minor allele frequency- T:0.01EU 721
    rs1484191531,2
    C--34597934(+) GGGGCA/GGACGG 1 -- ds50010--------
    rs1441000291,2
    C--34597947(+) GGCAGC/TGCTCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TUBGCP6 (50656118 - 50683421 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TUBGCP6 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724758CNV Deletion23290073
    esv2230097CNV Deletion18987734
    esv2724760CNV Deletion23290073
    esv2724759CNV Deletion23290073
    nsv471223CNV Loss18288195
    nsv915495CNV Loss21882294
    esv26829CNV Loss19812545
    nsv914517CNV Loss21882294
    dgv5055n71CNV Loss21882294
    nsv914518CNV Loss21882294

    Human Gene Mutation Database (HGMD): TUBGCP6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBGCP6
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBGCP6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610053   
    OMIM disorders: 251270  
    UniProtKB/Swiss-Prot: GCP6_HUMAN, Q96RT7
  • Microcephaly and chorioretinopathy with or without mental retardation, autosomal recessive (MCPHCR)
    [MIM:251270]: A syndrome characterized by microcephaly, cognitive impairment, underdeveloped retina and choroid,
    and epilepsy in some patients. The more anterior parts of the retina, near the periphery and pars plana, have a
    grayish hue and diminutive vasculature similar to retinopathy of prematurity. Visual impairment becomes evident
    during the first year of life. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 9 diseases for TUBGCP6:    
    About MalaCards
    microcephaly and chorioretinopathy with or without mental retardation    retinopathy of prematurity    microcephaly    choroiditis
    parkinson's disease    obesity    hiv-1    multiple myeloma
    myeloma


    TUBGCP6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TUBGCP6
    Human Genome Epidemiology (HuGE) Navigator: TUBGCP6 (1 document)

    Export disorders for TUBGCP6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBGCP6 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TUBGCP6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PubMed id 11694571)1, 2, 3 Murphy S.M.... Stearns T. (Mol. Biol. Cell 2001)
    2. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2, 3 Hirosawa M.... Ohara O. (DNA Res. 2001)
    3. Genetic mapping and exome sequencing identify variants associated with five novel diseases. (PubMed id 22279524)1, 2 Puffenberger E.G....Strauss K.A. (PLoS ONE 2012)
    4. Host determinants of HIV-1 control in African Americans. (PubMed id 20205591)1, 4 Pelak K.... . (J. Infect. Dis. 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PubMed id 24023788)1 Ong B.A....Hakonarson H. (PLoS ONE 2013)
    9. GCP6 is a substrate of Plk4 and required for centriole duplication. (PubMed id 22302995)1 Bahtz R....Hoffmann I. (J. Cell. Sci. 2012)
    10. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 85378 HGNC: 18127 AceView: TUBGCP6 Ensembl:ENSG00000128159 euGenes: HUgn85378
    ECgene: TUBGCP6 H-InvDB: TUBGCP6

    (According to HUGE)
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    HUGE: KIAA1669

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TUBGCP6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TUBGCP6 gene:
    Search GeneIP for patents involving TUBGCP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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