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Aliases for TUBGCP5 Gene

Aliases for TUBGCP5 Gene

  • Tubulin Gamma Complex Associated Protein 5 2 3 5
  • Gamma-Tubulin Complex Component GCP5 2 3
  • GCP5 3 4
  • Tubulin, Gamma Complex Associated Protein 5 2
  • Gamma-Tubulin Complex Component 5 3
  • KIAA1899 4
  • GCP-5 4

External Ids for TUBGCP5 Gene

Previous GeneCards Identifiers for TUBGCP5 Gene

  • GC15P019112
  • GC15M016124
  • GC15P020251
  • GC15P020381
  • GC15P020384
  • GC15P022833
  • GC15P001146

Summaries for TUBGCP5 Gene

GeneCards Summary for TUBGCP5 Gene

TUBGCP5 (Tubulin Gamma Complex Associated Protein 5) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and G-Beta Gamma Signaling. Gene Ontology (GO) annotations related to this gene include microtubule binding. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot for TUBGCP5 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP5 Gene

Additional gene information for TUBGCP5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP5 Gene

Genomics for TUBGCP5 Gene

GeneHancer (GH) Regulatory Elements for TUBGCP5 Gene

Promoters and enhancers for TUBGCP5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I023038 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.6 +0.4 418 2.2 HDGF PKNOX1 CLOCK ARID4B SIN3A DMAP1 YY1 SLC30A9 POLR2B ZNF207 TUBGCP5 NIPA2 HERC2P7 ENSG00000259098 CYFIP1
GH15I023036 Enhancer 0.6 ENCODE 0.8 +3.5 3540 0.2 SMARCA5 CTCF TFAP4 TRIM22 DACH1 MAX SIN3A MNT RAD21 PATZ1 TUBGCP5 CYFIP1
GH15I022989 Enhancer 0.5 ENCODE 0.2 +49.6 49599 0.4 CTCF ZFHX2 ZNF398 EGR2 CYFIP1 TUBGCP5
GH15I022990 Enhancer 0.2 ENCODE 0.2 +49.9 49920 0.2 CYFIP1 TUBGCP5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBGCP5 gene promoter:

Genomic Locations for TUBGCP5 Gene

Genomic Locations for TUBGCP5 Gene
chr15:22,983,192-23,039,673
(GRCh38/hg38)
Size:
56,482 bases
Orientation:
Minus strand
chr15:22,833,395-22,873,892
(GRCh37/hg19)

Genomic View for TUBGCP5 Gene

Genes around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP5 Gene

Proteins for TUBGCP5 Gene

  • Protein details for TUBGCP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RT8-GCP5_HUMAN
    Recommended name:
    Gamma-tubulin complex component 5
    Protein Accession:
    Q96RT8
    Secondary Accessions:
    • E9PB12
    • Q6IQ52
    • Q96PY8

    Protein attributes for TUBGCP5 Gene

    Size:
    1024 amino acids
    Molecular mass:
    118321 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
    SequenceCaution:
    • Sequence=AAH46182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK056416; Type=Erroneous termination; Positions=405; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AK056416; Type=Frameshift; Positions=713; Evidence={ECO:0000305}; Sequence=BAB67792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP5 Gene

Post-translational modifications for TUBGCP5 Gene

  • Ubiquitination at posLast=570570, isoforms=2590, and isoforms=2663

No data available for DME Specific Peptides for TUBGCP5 Gene

Domains & Families for TUBGCP5 Gene

Gene Families for TUBGCP5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUBGCP5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TUBGCP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RT8

UniProtKB/Swiss-Prot:

GCP5_HUMAN :
  • Belongs to the TUBGCP family.
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP5: view

Function for TUBGCP5 Gene

Molecular function for TUBGCP5 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Ontology (GO) - Molecular Function for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IBA --
GO:0008017 microtubule binding IDA 11694571
GO:0043015 gamma-tubulin binding IEA,IBA --
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP5: view
genes like me logo Genes that share phenotypes with TUBGCP5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP5 Gene

Localization for TUBGCP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBGCP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with TUBGCP5: view

Pathways & Interactions for TUBGCP5 Gene

genes like me logo Genes that share pathways with TUBGCP5: view

Interacting Proteins for TUBGCP5 Gene

Selected Interacting proteins: Q96RT8-GCP5_HUMAN for TUBGCP5 Gene via IID

Gene Ontology (GO) - Biological Process for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation IDA,IEA 11694571
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
GO:0051321 meiotic cell cycle IBA --
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center IBA --
genes like me logo Genes that share ontologies with TUBGCP5: view

No data available for SIGNOR curated interactions for TUBGCP5 Gene

Drugs & Compounds for TUBGCP5 Gene

No Compound Related Data Available

Transcripts for TUBGCP5 Gene

Unigene Clusters for TUBGCP5 Gene

Tubulin, gamma complex associated protein 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP5 Gene

No ASD Table

Relevant External Links for TUBGCP5 Gene

GeneLoc Exon Structure for
TUBGCP5
ECgene alternative splicing isoforms for
TUBGCP5

Expression for TUBGCP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBGCP5 Gene

Protein differential expression in normal tissues from HIPED for TUBGCP5 Gene

This gene is overexpressed in Heart (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBGCP5 Gene



Protein tissue co-expression partners for TUBGCP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP5 Gene:

TUBGCP5

SOURCE GeneReport for Unigene cluster for TUBGCP5 Gene:

Hs.533898

mRNA Expression by UniProt/SwissProt for TUBGCP5 Gene:

Q96RT8-GCP5_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.

Evidence on tissue expression from TISSUES for TUBGCP5 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TUBGCP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBGCP5 Gene

Orthologs for TUBGCP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBGCP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP5 33
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia TUBGCP5 33
  • 89.78 (n)
cow
(Bos Taurus)
Mammalia TUBGCP5 33
  • 89.55 (n)
mouse
(Mus musculus)
Mammalia Tubgcp5 33 16
  • 87.14 (n)
rat
(Rattus norvegicus)
Mammalia Tubgcp5 33
  • 87.04 (n)
chicken
(Gallus gallus)
Aves TUBGCP5 33
  • 78.6 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp5 33
  • 71.86 (n)
Str.18945 33
zebrafish
(Danio rerio)
Actinopterygii tubgcp5 33
  • 68.82 (n)
wufa03b04 33
fruit fly
(Drosophila melanogaster)
Insecta Grip128 33
  • 42.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001227 33
  • 41.17 (n)
Species where no ortholog for TUBGCP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP5 Gene

ENSEMBL:
Gene Tree for TUBGCP5 (if available)
TreeFam:
Gene Tree for TUBGCP5 (if available)

Paralogs for TUBGCP5 Gene

Paralogs for TUBGCP5 Gene

genes like me logo Genes that share paralogs with TUBGCP5: view

Variants for TUBGCP5 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP5 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000178951 -- 23,000,230(-) A/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000199392 -- 22,995,348(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000249905 -- 23,009,590(-) C/A intron_variant
rs1000271920 -- 23,041,363(-) C/T upstream_transcript_variant
rs1000337403 -- 22,992,795(-) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP5 Gene

Variant ID Type Subtype PubMed ID
dgv2403n100 CNV gain 25217958
dgv2404n100 CNV gain 25217958
dgv2405n100 CNV gain+loss 25217958
dgv2406n100 CNV gain 25217958
dgv2407n100 CNV gain+loss 25217958
dgv2408n100 CNV loss 25217958
dgv2409n100 CNV loss 25217958
dgv287n27 CNV gain 19166990
dgv4317n54 CNV loss 21841781
dgv4318n54 CNV gain 21841781
dgv4319n54 CNV gain+loss 21841781
dgv4320n54 CNV gain 21841781
dgv4322n54 CNV loss 21841781
dgv708e212 CNV loss 25503493
dgv709e212 CNV gain 25503493
dgv8n31 CNV loss 19718026
esv2474417 CNV loss 19546169
esv34463 CNV gain 17911159
esv3569265 CNV gain 25503493
esv3635806 CNV loss 21293372
esv3635807 CNV gain 21293372
esv3635815 CNV loss 21293372
esv3635816 CNV gain 21293372
esv3635817 CNV loss 21293372
esv3635818 CNV gain 21293372
esv3892604 CNV gain+loss 25118596
esv3892622 CNV gain 25118596
esv3892626 CNV gain+loss 25118596
nsv1036020 CNV loss 25217958
nsv1040546 CNV gain 25217958
nsv1113689 CNV deletion 24896259
nsv1459 CNV insertion 18451855
nsv433290 CNV loss 18776910
nsv433429 CNV gain 18776910
nsv442359 CNV gain+loss 18776908
nsv456612 CNV loss 19166990
nsv456635 CNV loss 19166990
nsv471225 CNV gain 18288195
nsv471226 CNV loss 18288195
nsv471375 CNV loss 19718026
nsv511042 OTHER inversion 20534489
nsv568225 CNV loss 21841781
nsv568226 CNV gain 21841781
nsv568235 CNV loss 21841781
nsv568258 CNV loss 21841781
nsv568259 CNV loss 21841781
nsv9183 CNV gain+loss 18304495

Variation tolerance for TUBGCP5 Gene

Residual Variation Intolerance Score: 6.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBGCP5 Gene

Human Gene Mutation Database (HGMD)
TUBGCP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBGCP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Disorders for TUBGCP5 Gene

Additional Disease Information for TUBGCP5

No disorders were found for TUBGCP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBGCP5 Gene

Publications for TUBGCP5 Gene

  1. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy SM … Stearns T (Molecular biology of the cell 2001) 2 3 4 58
  2. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. (PMID: 18316369) Izumi N … Kikuchi A (The Journal of biological chemistry 2008) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. (PMID: 14508708) Chai JH … Nicholls RD (American journal of human genetics 2003) 3 4 58

Products for TUBGCP5 Gene

Sources for TUBGCP5 Gene

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