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Aliases for TUBGCP5 Gene

Aliases for TUBGCP5 Gene

  • Tubulin Gamma Complex Associated Protein 5 2 3 5
  • Tubulin, Gamma Complex Associated Protein 5 2 3
  • Gamma-Tubulin Complex Component GCP5 2 3
  • GCP-5 3 4
  • GCP5 3 4
  • KIAA1899 4

External Ids for TUBGCP5 Gene

Previous GeneCards Identifiers for TUBGCP5 Gene

  • GC15P019112
  • GC15M016124
  • GC15P020251
  • GC15P020381
  • GC15P020384
  • GC15P022833
  • GC15P001146

Summaries for TUBGCP5 Gene

GeneCards Summary for TUBGCP5 Gene

TUBGCP5 (Tubulin Gamma Complex Associated Protein 5) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Chks in Checkpoint Regulation. GO annotations related to this gene include microtubule binding. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot for TUBGCP5 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP5 Gene

Genomics for TUBGCP5 Gene

Regulatory Elements for TUBGCP5 Gene

Enhancers for TUBGCP5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Promoters for TUBGCP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBGCP5 Gene

22,983,192 bp from pter
23,039,673 bp from pter
56,482 bases
Minus strand

Genomic View for TUBGCP5 Gene

Genes around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP5 Gene

Proteins for TUBGCP5 Gene

  • Protein details for TUBGCP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-tubulin complex component 5
    Protein Accession:
    Secondary Accessions:
    • E9PB12
    • Q6IQ52
    • Q96PY8

    Protein attributes for TUBGCP5 Gene

    1024 amino acids
    Molecular mass:
    118321 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
    • Sequence=AAH46182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK056416; Type=Erroneous termination; Positions=405; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AK056416; Type=Frameshift; Positions=713; Evidence={ECO:0000305}; Sequence=BAB67792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP5 Gene


neXtProt entry for TUBGCP5 Gene

Proteomics data for TUBGCP5 Gene at MOPED

Post-translational modifications for TUBGCP5 Gene

  • Ubiquitination at Lys 570, Lys 590, and Lys 663
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBGCP5 Gene

No data available for DME Specific Peptides for TUBGCP5 Gene

Domains & Families for TUBGCP5 Gene

Protein Domains for TUBGCP5 Gene


Suggested Antigen Peptide Sequences for TUBGCP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TUBGCP family.
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP5: view

No data available for Gene Families for TUBGCP5 Gene

Function for TUBGCP5 Gene

Molecular function for TUBGCP5 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.
genes like me logo Genes that share phenotypes with TUBGCP5: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP5 Gene

Localization for TUBGCP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Jensen Localization Image for TUBGCP5 Gene COMPARTMENTS Subcellular localization image for TUBGCP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with TUBGCP5: view

Pathways & Interactions for TUBGCP5 Gene

genes like me logo Genes that share pathways with TUBGCP5: view

Interacting Proteins for TUBGCP5 Gene

Selected Interacting proteins: Q96RT8-GCP5_HUMAN for TUBGCP5 Gene via I2D

Gene Ontology (GO) - Biological Process for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007020 microtubule nucleation IDA 11694571
GO:0007126 meiotic nuclear division IBA --
genes like me logo Genes that share ontologies with TUBGCP5: view

No data available for SIGNOR curated interactions for TUBGCP5 Gene

Drugs & Compounds for TUBGCP5 Gene

No Compound Related Data Available

Transcripts for TUBGCP5 Gene

Unigene Clusters for TUBGCP5 Gene

Tubulin, gamma complex associated protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP5 Gene

No ASD Table

Relevant External Links for TUBGCP5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBGCP5 Gene

mRNA expression in normal human tissues for TUBGCP5 Gene

Protein differential expression in normal tissues from HIPED for TUBGCP5 Gene

This gene is overexpressed in Heart (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TUBGCP5 Gene

SOURCE GeneReport for Unigene cluster for TUBGCP5 Gene Hs.533898

mRNA Expression by UniProt/SwissProt for TUBGCP5 Gene

Tissue specificity: Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.
genes like me logo Genes that share expression patterns with TUBGCP5: view

Protein tissue co-expression partners for TUBGCP5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TUBGCP5 Gene

Orthologs for TUBGCP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBGCP5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TUBGCP5 35
  • 89.55 (n)
  • 92.09 (a)
(Canis familiaris)
Mammalia TUBGCP5 35
  • 89.78 (n)
  • 92.77 (a)
(Mus musculus)
Mammalia Tubgcp5 35
  • 87.14 (n)
  • 88.48 (a)
Tubgcp5 16
(Pan troglodytes)
Mammalia TUBGCP5 35
  • 99.45 (n)
  • 99.61 (a)
(Rattus norvegicus)
Mammalia Tubgcp5 35
  • 87.04 (n)
  • 88.87 (a)
(Gallus gallus)
Aves TUBGCP5 35
  • 78.6 (n)
  • 85.56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18945 35
tubgcp5 35
  • 71.86 (n)
  • 78.42 (a)
(Danio rerio)
Actinopterygii tubgcp5 35
  • 68.82 (n)
  • 73.49 (a)
wufa03b04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001227 35
  • 41.17 (n)
  • 25.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Grip128 35
  • 42.92 (n)
  • 21.89 (a)
Species with no ortholog for TUBGCP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP5 Gene

Gene Tree for TUBGCP5 (if available)
Gene Tree for TUBGCP5 (if available)

Paralogs for TUBGCP5 Gene

Paralogs for TUBGCP5 Gene

genes like me logo Genes that share paralogs with TUBGCP5: view

Variants for TUBGCP5 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs35612840 - 23,010,103(+) AACTT(C/G)TCGTG reference, missense
rs548 -- 22,999,284(-) TCTTA(C/T)ATTTC intron-variant, utr-variant-3-prime
rs5006363 -- 23,025,556(-) CGCGC(A/C/T)GGTAG intron-variant
rs11858194 -- 23,017,126(-) agatc(A/G)acatt intron-variant
rs11858799 -- 23,022,279(-) AAATC(C/T)ACCGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP5 Gene

Variant ID Type Subtype PubMed ID
dgv669e1 CNV Complex 17122850
nsv428296 CNV Gain+Loss 18775914
dgv93e55 CNV Gain 17911159
dgv679e1 CNV Complex 17122850
dgv44n16 CNV Insertion 17901297
esv2751489 CNV Gain 17911159
esv34233 CNV Loss 17911159
essv13315 CNV CNV 17122850
dgv693e1 CNV Complex 17122850
nsv437797 CNV Loss 16327808
dgv695e1 CNV Complex 17122850
esv26683 CNV Gain+Loss 19812545
nsv511042 OTHER Inversion 20534489
nsv433429 CNV Gain 18776910
nsv903495 CNV Gain 21882294
esv2474417 CNV Loss 19546169
nsv442359 CNV CNV 18776908
nsv832924 CNV Loss 17160897
dgv696e1 CNV Complex 17122850
nsv903498 CNV Gain 21882294
dgv2233n71 CNV Gain 21882294
dgv2234n71 CNV Loss 21882294
dgv2235n71 CNV Gain 21882294
dgv2236n71 CNV Gain+Loss 21882294
nsv433290 CNV Loss 18776910
dgv2237n71 CNV Gain 21882294
dgv2238n71 CNV Loss 21882294
dgv2239n71 CNV Gain 21882294
nsv456612 CNV Loss 19166990
dgv287n27 CNV Gain 19166990
nsv471225 CNV Gain 18288195
nsv471226 CNV Loss 18288195
dgv2240n71 CNV Gain 21882294
esv34463 CNV Gain 17911159
essv24027 CNV CNV 17122850
dgv2241n71 CNV Gain 21882294
dgv8n31 CNV Deletion 19718026
nsv1459 CNV Insertion 18451855
nsv9183 CNV Gain+Loss 18304495
dgv2242n71 CNV Gain 21882294
nsv471375 CNV Deletion 19718026
nsv903548 CNV Loss 21882294
nsv456635 CNV Loss 19166990
essv13814 CNV CNV 17122850

Variation tolerance for TUBGCP5 Gene

Residual Variation Intolerance Score: 6.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBGCP5 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Disorders for TUBGCP5 Gene

Relevant External Links for TUBGCP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TUBGCP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBGCP5 Gene

Publications for TUBGCP5 Gene

  1. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy S.M. … Stearns T. (Mol. Biol. Cell 2001) 2 3 4 67
  2. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. (PMID: 18316369) Izumi N. … Kikuchi A. (J. Biol. Chem. 2008) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TUBGCP5 Gene

Sources for TUBGCP5 Gene