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Aliases for TUBGCP5 Gene

Aliases for TUBGCP5 Gene

  • Tubulin Gamma Complex Associated Protein 5 2 3 5
  • Gamma-Tubulin Complex Component GCP5 2 3
  • GCP-5 3 4
  • GCP5 3 4
  • Tubulin, Gamma Complex Associated Protein 5 2
  • Gamma-Tubulin Complex Component 5 3
  • KIAA1899 4

External Ids for TUBGCP5 Gene

Previous GeneCards Identifiers for TUBGCP5 Gene

  • GC15P019112
  • GC15M016124
  • GC15P020251
  • GC15P020381
  • GC15P020384
  • GC15P022833
  • GC15P001146

Summaries for TUBGCP5 Gene

GeneCards Summary for TUBGCP5 Gene

TUBGCP5 (Tubulin Gamma Complex Associated Protein 5) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Chks in Checkpoint Regulation. GO annotations related to this gene include microtubule binding. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot for TUBGCP5 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP5 Gene

Genomics for TUBGCP5 Gene

Regulatory Elements for TUBGCP5 Gene

Enhancers for TUBGCP5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F023038 1.1 ENCODE 6.6 +0.4 419 2.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207 HERC2P7 TUBGCP5 CYFIP1
GH15F023036 0.7 ENCODE 0.8 +3.5 3541 0.2 BCOR CTCF TFAP4 WRNIP1 MAX TRIM22 ZBTB7A RAD21 PATZ1 ZNF143 TUBGCP5 CYFIP1
GH15F022989 0.5 ENCODE 0.2 +49.6 49600 0.4 CTCF ZFHX2 EGR2 CYFIP1 TUBGCP5
GH15F022990 0.2 ENCODE 0.2 +49.9 49921 0.2 CYFIP1 TUBGCP5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Promoters for TUBGCP5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000404770 373 2200 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF207

Genomic Location for TUBGCP5 Gene

Chromosome:
15
Start:
22,983,192 bp from pter
End:
23,039,673 bp from pter
Size:
56,482 bases
Orientation:
Minus strand

Genomic View for TUBGCP5 Gene

Genes around TUBGCP5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP5 Gene

Proteins for TUBGCP5 Gene

  • Protein details for TUBGCP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RT8-GCP5_HUMAN
    Recommended name:
    Gamma-tubulin complex component 5
    Protein Accession:
    Q96RT8
    Secondary Accessions:
    • E9PB12
    • Q6IQ52
    • Q96PY8

    Protein attributes for TUBGCP5 Gene

    Size:
    1024 amino acids
    Molecular mass:
    118321 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
    SequenceCaution:
    • Sequence=AAH46182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK056416; Type=Erroneous termination; Positions=405; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AK056416; Type=Frameshift; Positions=713; Evidence={ECO:0000305}; Sequence=BAB67792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP5 Gene

Post-translational modifications for TUBGCP5 Gene

  • Ubiquitination at Lys 570, Lys 590, and Lys 663
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TUBGCP5
  • Santa Cruz Biotechnology (SCBT) Antibodies for TUBGCP5

No data available for DME Specific Peptides for TUBGCP5 Gene

Domains & Families for TUBGCP5 Gene

Protein Domains for TUBGCP5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TUBGCP5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96RT8

UniProtKB/Swiss-Prot:

GCP5_HUMAN :
  • Belongs to the TUBGCP family.
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP5: view

No data available for Gene Families for TUBGCP5 Gene

Function for TUBGCP5 Gene

Molecular function for TUBGCP5 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Ontology (GO) - Molecular Function for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IBA --
GO:0008017 microtubule binding IDA 11694571
GO:0043015 gamma-tubulin binding IEA,IBA --
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP5: view
genes like me logo Genes that share phenotypes with TUBGCP5: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP5 Gene

Localization for TUBGCP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBGCP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005737 cytoplasm IEA,IDA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with TUBGCP5: view

Pathways & Interactions for TUBGCP5 Gene

genes like me logo Genes that share pathways with TUBGCP5: view

Interacting Proteins for TUBGCP5 Gene

Selected Interacting proteins: Q96RT8-GCP5_HUMAN for TUBGCP5 Gene via IID

Gene Ontology (GO) - Biological Process for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation IEA,IDA 11694571
GO:0007126 meiotic nuclear division IBA --
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center IBA --
genes like me logo Genes that share ontologies with TUBGCP5: view

No data available for SIGNOR curated interactions for TUBGCP5 Gene

Transcripts for TUBGCP5 Gene

Unigene Clusters for TUBGCP5 Gene

Tubulin, gamma complex associated protein 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP5 Gene

No ASD Table

Relevant External Links for TUBGCP5 Gene

GeneLoc Exon Structure for
TUBGCP5
ECgene alternative splicing isoforms for
TUBGCP5

Expression for TUBGCP5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUBGCP5 Gene

Protein differential expression in normal tissues from HIPED for TUBGCP5 Gene

This gene is overexpressed in Heart (57.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TUBGCP5 Gene



Protein tissue co-expression partners for TUBGCP5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP5 Gene:

TUBGCP5

SOURCE GeneReport for Unigene cluster for TUBGCP5 Gene:

Hs.533898

mRNA Expression by UniProt/SwissProt for TUBGCP5 Gene:

Q96RT8-GCP5_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.
genes like me logo Genes that share expression patterns with TUBGCP5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TUBGCP5 Gene

Orthologs for TUBGCP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBGCP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP5 34
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia TUBGCP5 34
  • 89.78 (n)
cow
(Bos Taurus)
Mammalia TUBGCP5 34
  • 89.55 (n)
mouse
(Mus musculus)
Mammalia Tubgcp5 34 16
  • 87.14 (n)
rat
(Rattus norvegicus)
Mammalia Tubgcp5 34
  • 87.04 (n)
chicken
(Gallus gallus)
Aves TUBGCP5 34
  • 78.6 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp5 34
  • 71.86 (n)
Str.18945 34
zebrafish
(Danio rerio)
Actinopterygii tubgcp5 34
  • 68.82 (n)
wufa03b04 34
fruit fly
(Drosophila melanogaster)
Insecta Grip128 34
  • 42.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001227 34
  • 41.17 (n)
Species where no ortholog for TUBGCP5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP5 Gene

ENSEMBL:
Gene Tree for TUBGCP5 (if available)
TreeFam:
Gene Tree for TUBGCP5 (if available)

Paralogs for TUBGCP5 Gene

Paralogs for TUBGCP5 Gene

genes like me logo Genes that share paralogs with TUBGCP5: view

Variants for TUBGCP5 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1015172 -- 23,033,097(+) ACGAC(A/G)GAAAT intron-variant, upstream-variant-2KB
rs10152252 -- 23,035,315(-) tgtca(C/T)tttgt intron-variant
rs10152262 -- 23,035,226(-) tcagc(C/T)tcccg intron-variant
rs10152479 -- 23,035,203(-) tacag(C/G)tgccc intron-variant
rs10152489 -- 23,035,061(-) catga(A/G)ccacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP5 Gene

Variant ID Type Subtype PubMed ID
nsv9183 CNV gain+loss 18304495
nsv568259 CNV loss 21841781
nsv568258 CNV loss 21841781
nsv568235 CNV loss 21841781
nsv568226 CNV gain 21841781
nsv568225 CNV loss 21841781
nsv511042 OTHER inversion 20534489
nsv471375 CNV loss 19718026
nsv471226 CNV loss 18288195
nsv471225 CNV gain 18288195
nsv456635 CNV loss 19166990
nsv456612 CNV loss 19166990
nsv442359 CNV gain+loss 18776908
nsv433429 CNV gain 18776910
nsv433290 CNV loss 18776910
nsv1459 CNV insertion 18451855
nsv1113689 CNV deletion 24896259
nsv1040546 CNV gain 25217958
nsv1036020 CNV loss 25217958
esv3892626 CNV gain+loss 25118596
esv3892622 CNV gain 25118596
esv3892604 CNV gain+loss 25118596
esv3635818 CNV gain 21293372
esv3635817 CNV loss 21293372
esv3635816 CNV gain 21293372
esv3635815 CNV loss 21293372
esv3635807 CNV gain 21293372
esv3635806 CNV loss 21293372
esv3569265 CNV gain 25503493
esv34463 CNV gain 17911159
esv2474417 CNV loss 19546169
dgv8n31 CNV loss 19718026
dgv709e212 CNV gain 25503493
dgv708e212 CNV loss 25503493
dgv4322n54 CNV loss 21841781
dgv4320n54 CNV gain 21841781
dgv4319n54 CNV gain+loss 21841781
dgv4318n54 CNV gain 21841781
dgv4317n54 CNV loss 21841781
dgv287n27 CNV gain 19166990
dgv2409n100 CNV loss 25217958
dgv2408n100 CNV loss 25217958
dgv2407n100 CNV gain+loss 25217958
dgv2406n100 CNV gain 25217958
dgv2405n100 CNV gain+loss 25217958
dgv2404n100 CNV gain 25217958
dgv2403n100 CNV gain 25217958

Variation tolerance for TUBGCP5 Gene

Residual Variation Intolerance Score: 6.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBGCP5 Gene

Human Gene Mutation Database (HGMD)
TUBGCP5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBGCP5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Disorders for TUBGCP5 Gene

Relevant External Links for TUBGCP5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBGCP5

No disorders were found for TUBGCP5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBGCP5 Gene

Publications for TUBGCP5 Gene

  1. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy S.M. … Stearns T. (Mol. Biol. Cell 2001) 2 3 4 64
  2. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. (PMID: 18316369) Izumi N. … Kikuchi A. (J. Biol. Chem. 2008) 3 22 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. (PMID: 14508708) Chai J.-H. … Nicholls R.D. (Am. J. Hum. Genet. 2003) 3 4 64

Products for TUBGCP5 Gene

Sources for TUBGCP5 Gene

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