Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TUBGCP5 Gene

protein-coding   GIFtS: 56
GCID: GC15P022833

Tubulin, Gamma Complex Associated Protein 5

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tubulin, Gamma Complex Associated Protein 51 2
GCP52 3 5
Gamma-Tubulin Complex Component GCP51 2
GCP-52 3
KIAA18993 5
Gamma-Tubulin Complex Component 52

External Ids:    HGNC: 186001   Entrez Gene: 1147912   Ensembl: ENSG000001535757   OMIM: 6081475   UniProtKB: Q96RT83   

Export aliases for TUBGCP5 gene to outside databases

Previous GC identifers: GC15P019112 GC15M016124 GC15P020251 GC15P020381 GC15P020384 GC15P001146


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TUBGCP5 Gene:
TUBGCP5 (tubulin, gamma complex associated protein 5) is a protein-coding gene. Diseases associated with TUBGCP5 include prader-willi syndrome, and angelman syndrome. GO annotations related to this gene include microtubule binding. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot: GCP5_HUMAN, Q96RT8
Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Wiki entry for TUBGCP5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000015.10  NT_078094.3  NT_187603.1  NC_018926.2  NT_187659.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBGCP5 gene promoter:
         Sox5   Nkx2-2   FOXD3   POU3F2   C/EBPalpha   POU2F1   FOXC1   POU2F1a   Sox9   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBGCP5 promoter sequence
   Search Chromatin IP Primers for TUBGCP5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBGCP5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q11.2   Ensembl cytogenetic band:  15q11.2   HGNC cytogenetic band: 15q11.1

TUBGCP5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBGCP5 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P022833:  view genomic region     (about GC identifiers)

Start:
22,833,395 bp from pter      End:
22,873,892 bp from pter
Size:
40,498 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GCP5_HUMAN, Q96RT8 (See protein sequence)
Recommended Name: Gamma-tubulin complex component 5  
Size: 1024 amino acids; 118321 Da
Subunit: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6
Sequence caution: Sequence=AAH46182.1; Type=Erroneous initiation; Sequence=AK056416; Type=Erroneous termination;
Positions=405; Note=Translated as Arg; Sequence=AK056416; Type=Frameshift; Positions=713; Sequence=BAB67792.2;
Type=Erroneous initiation;
Secondary accessions: E9PB12 Q6IQ52 Q96PY8
Alternative splicing: 2 isoforms:  Q96RT8-1   Q96RT8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TUBGCP5: NX_Q96RT8

Explore proteomics data for TUBGCP5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys570, Lys590, Lys663
  • Modification sites at PhosphoSitePlus

  • See TUBGCP5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001096080.1  NP_443135.3  

    ENSEMBL proteins: 
     ENSP00000283645   ENSP00000409217   ENSP00000453810   ENSP00000453197  
    Reactome Protein details: Q96RT8

    TUBGCP5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TUBGCP5
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TUBGCP5
    GenScript Custom Purified and Recombinant Proteins Services for TUBGCP5
    Novus Biologicals TUBGCP5 Proteins
    Novus Biologicals TUBGCP5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TUBGCP5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TUBGCP5
    OriGene Custom Antibody Services for TUBGCP5
    Novus Biologicals TUBGCP5 Antibodies
    Abcam antibodies for TUBGCP5
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for TUBGCP5
    LSBio Antibodies in human, mouse, rat for TUBGCP5

    TUBGCP5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TUBGCP5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TUBGCP5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR007259 TUBGCP

    Graphical View of Domain Structure for InterPro Entry Q96RT8

    ProtoNet protein and cluster: Q96RT8

    1 Blocks protein domain: IPB007259 Spc97/Spc98

    UniProtKB/Swiss-Prot: GCP5_HUMAN, Q96RT8
    Similarity: Belongs to the TUBGCP family


    TUBGCP5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCP5_HUMAN, Q96RT8
    Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008017microtubule binding IDA11694571
         
    TUBGCP5 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TUBGCP5:
     Decreased viability with pacli  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBGCP5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBGCP5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBGCP5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUBGCP5

    miRNA
    Products:
        
    miRTarBase miRNAs that target TUBGCP5:
    hsa-mir-21-5p (MIRT030812)

    Block miRNA regulation of human, mouse, rat TUBGCP5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TUBGCP5:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUBGCP5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TUBGCP5
    Predesigned siRNA for gene silencing in human, mouse, rat TUBGCP5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TUBGCP5

    Clone
    Products:
         
    OriGene clones in human, mouse for TUBGCP5 (see all 12)
    OriGene ORF clones in mouse, rat for TUBGCP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TUBGCP5 (NM_052903)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBGCP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBGCP5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TUBGCP5
    Browse ESI BIO Cell Lines and PureStem Progenitors for TUBGCP5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GCP5_HUMAN, Q96RT8: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005813centrosome IDA--

    TUBGCP5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TUBGCP5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Mitotic G2-G2/M phases0.69
    Centrosome maturation0.86
    Recruitment of NuMA to mitotic centrosomes0.00
    G2/M Transition0.70
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    3Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    4G-Beta Gamma Signaling
    Hedgehog Signaling in Mammals0.32
    5CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBGCP5
        14-3-3 Induced Intracellular Signaling
    Hedgehog Signaling in Mammals
    Parkinson's Disease Pathway

    2 Reactome Pathways for TUBGCP5
        Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes



    TUBGCP5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBGCP5
    Interactions:

        GeneGlobe Interaction Network for TUBGCP5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBGCP5 (Q96RT83 ENSP000002836454) via UniProtKB, MINT, STRING, and/or I2D (see all 63)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MZT1Q08AG73, ENSP000003670494I2D: score=1 STRING: ENSP00000367049
    MZT2BQ6NZ673, ENSP000002818714I2D: score=1 STRING: ENSP00000281871
    TUBG1P232583, ENSP000002514134I2D: score=1 STRING: ENSP00000251413
    TUBGCP3Q96CW53, ENSP000002619654I2D: score=1 STRING: ENSP00000261965
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization ----
    GO:0000278mitotic cell cycle TAS--
    GO:0007020microtubule nucleation IDA11694571

    TUBGCP5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TUBGCP5 (GCP5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TUBGCP5 gene (2 alternative transcripts): 
    NM_001102610.1  NM_052903.4  

    Unigene Cluster for TUBGCP5:

    Tubulin, gamma complex associated protein 5
    Hs.533898  [show with all ESTs]
    Unigene Representative Sequence: NM_052903
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283645(uc001yur.4) ENST00000453949(uc001yuq.2) ENST00000558664
    ENST00000559846(uc010axz.1) ENST00000561214 ENST00000559534 ENST00000558915


    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TUBGCP5 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TUBGCP5:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUBGCP5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TUBGCP5
    Predesigned siRNA for gene silencing in human, mouse, rat TUBGCP5
    Clone
    Products:
         
    OriGene clones in human, mouse for TUBGCP5 (see all 12)
    OriGene ORF clones in mouse, rat for TUBGCP5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TUBGCP5 (NM_052903)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBGCP5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBGCP5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TUBGCP5
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBGCP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBGCP5
      QuantiTect SYBR Green Assays in human, mouse, rat TUBGCP5
      QuantiFast Probe-based Assays in human, mouse, rat TUBGCP5

    Additional mRNA sequence: 

    AB067486.2 AF272884.1 AK023934.1 AK056416.1 AK289859.1 AK310897.1 BC039271.1 BC046182.1 
    BC071560.1 

    8 DOTS entries:

    DT.412181  DT.99938155  DT.99998370  DT.100704722  DT.100755462  DT.91666827  DT.40229124  DT.99969861 

    Selected AceView cDNA sequences (see all 93):

    AI275748 BE047583 AA884196 AL705635 BE042758 AL559975 BP341692 AI880634 
    AL705553 AA580766 AI863224 AI126731 BX109178 BC039271 BC046182 AF272884 
    BF793215 CA427485 AK023934 BM994102 AU141845 AL705466 AI628925 BP362649 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP5 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                          -           -                                 
    SP5:                          -           -                                 


    ECgene alternative splicing isoforms for TUBGCP5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TUBGCP5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTGTGTA
    TUBGCP5 Expression
    About this image

    TUBGCP5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBGCP5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533898

    UniProtKB/Swiss-Prot: GCP5_HUMAN, Q96RT8
    Tissue specificity: Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in
    brain

        Custom PCR Arrays for TUBGCP5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUBGCP5
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBGCP5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBGCP5
    QuantiTect SYBR Green Assays in human, mouse, rat TUBGCP5
    QuantiFast Probe-based Assays in human, mouse, rat TUBGCP5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TUBGCP5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubgcp51 , 5 tubulin, gamma complex associated protein 51, 5 87.14(n)1
    88.48(a)1
      7 (33.42 cM)5
    2332761  NM_146190.21  NP_666302.21 
     557941485 
    chicken
    (Gallus gallus)
    Aves TUBGCP51 tubulin, gamma complex associated protein 5 78.6(n)
    85.56(a)
      100858683  XM_004938461.1  XP_004938518.1 
    lizard
    (Anolis carolinensis)
    Reptilia TUBGCP56
    tubulin, gamma complex associated protein 5
    76(a)
    1 ↔ 1
    3(111842118-111869513)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.189452 Transcribed sequences 80.27(n)    CF152278.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa03b042 wufa03b04 73.69(n)   334762  57059807 
    fruit fly
    (Drosophila melanogaster)
    Insecta Grip1281 Grip128 42.92(n)
    21.89(a)
      32478  NM_132802.3  NP_573030.2 


    ENSEMBL Gene Tree for TUBGCP5 (if available)
    TreeFam Gene Tree for TUBGCP5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TUBGCP5 gene
    TUBGCP62  

    TUBGCP5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TUBGCP5 (see all 1163)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2019129001,2
    C--22831424(+) GTGTGC/GTTATG 2 -- us2k10--------
    rs758322871,2
    C--22831488(+) TATGGC/TCAGCT 2 -- us2k10--------
    rs125942991,2
    C,A,H--22831527(+) TGGCCA/CGGTGA 2 -- us2k1 tfbs30--------
    rs125914351,2
    C,H--22831528(+) GGCCAA/GGTGAC 2 -- us2k1 tfbs30--------
    rs38941201,2
    C--22831652(-) CATAAC/TCCCAC 2 -- us2k10--------
    rs125943291,2
    H--22831668(+) CCCCTA/GGCACC 2 -- us2k10--------
    rs590967481,2
    C--22831692(+) GGTTAA/TGATGT 2 -- us2k10--------
    rs74953231,2
    C--22831722(+) AGGTTA/GGGTTA 2 -- us2k10--------
    rs773913871,2
    C--22831791(+) TGGCCA/GGGTGG 2 -- us2k10--------
    rs611604031,2
    C--22831817(+) CCCGCC/TCCCCA 2 -- us2k11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for TUBGCP5 (22833395 - 22873892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TUBGCP5 (see all 44):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv8n31CNV Deletion19718026
    nsv471375CNV Deletion19718026
    nsv1459CNV Insertion18451855
    dgv44n16CNV Insertion17901297
    nsv471226CNV Loss18288195
    nsv832924CNV Loss17160897
    nsv437797CNV Loss16327808
    esv34233CNV Loss17911159
    nsv903548CNV Loss21882294
    dgv2234n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): TUBGCP5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBGCP5
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBGCP5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608147    OMIM disorders: --

    4 diseases for TUBGCP5:    About MalaCards
    prader-willi syndrome    angelman syndrome    parkinson's disease    malaria

    1 disease from the University of Copenhagen DISEASES database for TUBGCP5:
    Angelman syndrome

    TUBGCP5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for TUBGCP5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TUBGCP5 gene, integrated from 10 sources (see all 22):
    (articles sorted by number of sources associating them with TUBGCP5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PubMed id 11694571)1, 2, 3 Murphy S.M.... Stearns T. (Mol. Biol. Cell 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. (PubMed id 14508708)1, 2 Chai J.-H.... Nicholls R.D. (Am. J. Hum. Genet. 2003)
    5. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
    6. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. (PubMed id 18316369)1, 9 Izumi N....Kikuchi A. (J. Biol. Chem. 2008)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 114791 HGNC: 18600 AceView: TUBGCP5 Ensembl:ENSG00000153575 euGenes: HUgn114791
    ECgene: TUBGCP5 H-InvDB: TUBGCP5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1899

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TUBGCP5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TUBGCP5 gene:
    Search GeneIP for patents involving TUBGCP5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TUBGCP5   OriGene RNAi products in human, mouse, rat for TUBGCP5  
     OriGene qPCR primer pairs and template standards for TUBGCP5   OriGene Protein Over-expression Lysate for TUBGCP5  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TUBGCP5  
     OriGene qSTAR qPCR primer pairs in human, mouse for TUBGCP5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TUBGCP5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TUBGCP5   OriGene Custom Protein Services for TUBGCP5  

     
     
     Block miRNA regulation of human, mouse, rat TUBGCP5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TUBGCP5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBGCP5 Predesigned siRNA for gene silencing in human, mouse, rat TUBGCP5
     QuantiFast Probe-based Assays in human, mouse, rat TUBGCP5 QuantiTect SYBR Green Assays in human, mouse, rat TUBGCP5
     Custom PCR Arrays for TUBGCP5 Search Chromatin IP Primers for TUBGCP5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBGCP5  GeneGlobe Interaction Network for TUBGCP5
     Regulatory tfbs in TUBGCP5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TUBGCP5 GenScript cDNA clones with any tag delivered in your preferred vector for TUBGCP5
     GenScript Custom Assay Services for TUBGCP5 GenScript Custom overexpressing Cell Line Services for TUBGCP5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TUBGCP5 (GCP5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TUBGCP5 antibodies
     TUBGCP5 proteins
     TUBGCP5 lysates
     Antibodies for TUBGCP5
     See all of Abcam's Antibodies, Kits and Proteins for TUBGCP5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TUBGCP5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP5
     SwitchGear 3'UTR luciferase reporter plasmids for TUBGCP5
     SwitchGear Promoter luciferase reporter plasmids for TUBGCP5
     Search ThermoFisher Antibodies for TUBGCP5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBGCP5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBGCP5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBGCP5
     LSBio Antibodies in human, mouse, rat for TUBGCP5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TUBGCP5 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4