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Aliases for TUBGCP5 Gene

Aliases for TUBGCP5 Gene

  • Tubulin, Gamma Complex Associated Protein 5 2 3
  • GCP5 3 4 6
  • Gamma-Tubulin Complex Component GCP5 2 3
  • KIAA1899 4 6
  • GCP-5 3 4
  • Gamma-Tubulin Complex Component 5 3

External Ids for TUBGCP5 Gene

Summaries for TUBGCP5 Gene

GeneCards Summary for TUBGCP5 Gene

TUBGCP5 (Tubulin, Gamma Complex Associated Protein 5) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cell Cycle, Mitotic. GO annotations related to this gene include microtubule binding.

UniProtKB/Swiss-Prot for TUBGCP5 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Wiki entry for TUBGCP5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP5 Gene

Genomics for TUBGCP5 Gene

Genomic Location for TUBGCP5 Gene

Start:
22,983,192 bp from pter
End:
23,039,673 bp from pter
Size:
56,482 bases
Orientation:
Minus strand

Genomic View for TUBGCP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBGCP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP5 Gene

Regulatory Elements for TUBGCP5 Gene

Proteins for TUBGCP5 Gene

  • Protein details for TUBGCP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96RT8-GCP5_HUMAN
    Recommended name:
    Gamma-tubulin complex component 5
    Protein Accession:
    Q96RT8
    Secondary Accessions:
    • E9PB12
    • Q6IQ52
    • Q96PY8

    Protein attributes for TUBGCP5 Gene

    Size:
    1024 amino acids
    Molecular mass:
    118321 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6
    SequenceCaution:
    • Sequence=AAH46182.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AK056416; Type=Erroneous termination; Positions=405; Note=Translated as Arg.; Evidence={ECO:0000305}; Sequence=AK056416; Type=Frameshift; Positions=713; Evidence={ECO:0000305}; Sequence=BAB67792.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP5 Gene

Proteomics data for TUBGCP5 Gene at MOPED

Post-translational modifications for TUBGCP5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys570, Lys590, and Lys663

Other Protein References for TUBGCP5 Gene

No data available for DME Specific Peptides for TUBGCP5 Gene

Domains for TUBGCP5 Gene

Protein Domains for TUBGCP5 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

GCP5_HUMAN
Family:
  • Belongs to the TUBGCP family.:
    • Q96RT8
genes like me logo Genes that share domains with TUBGCP5: view

No data available for Gene Families for TUBGCP5 Gene

Function for TUBGCP5 Gene

Molecular function for TUBGCP5 Gene

UniProtKB/Swiss-Prot Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Ontology (GO) - Molecular Function for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008017 microtubule binding IDA 11694571
genes like me logo Genes that share ontologies with TUBGCP5: view

Phenotypes for TUBGCP5 Gene

genes like me logo Genes that share phenotypes with TUBGCP5: view

miRNA for TUBGCP5 Gene

miRTarBase miRNAs that target TUBGCP5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBGCP5 Gene

Localization for TUBGCP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP5 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBGCP5 Gene COMPARTMENTS Subcellular localization image for TUBGCP5 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with TUBGCP5: view

Pathways for TUBGCP5 Gene

genes like me logo Genes that share pathways with TUBGCP5: view

Interacting Proteins for TUBGCP5 Gene

Selected Interacting proteins: Q96RT8-GCP5_HUMAN for TUBGCP5 Gene via I2D

Gene Ontology (GO) - Biological Process for TUBGCP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000226 microtubule cytoskeleton organization --
GO:0000278 mitotic cell cycle TAS --
GO:0007020 microtubule nucleation IDA 11694571
genes like me logo Genes that share ontologies with TUBGCP5: view

Transcripts for TUBGCP5 Gene

Unigene Clusters for TUBGCP5 Gene

Tubulin, gamma complex associated protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b · 17c ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8: - -
SP9:
SP10: -
SP11:
SP12:

ExUns: 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25
SP1:
SP2:
SP3:
SP4: - -
SP5: - -
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:

Relevant External Links for TUBGCP5 Gene

GeneLoc Exon Structure for
TUBGCP5
ECgene alternative splicing isoforms for
TUBGCP5

Expression for TUBGCP5 Gene

mRNA expression in normal human tissues for TUBGCP5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TUBGCP5 Gene

SOURCE GeneReport for Unigene cluster for TUBGCP5 Gene Hs.533898

mRNA Expression by UniProt/SwissProt for TUBGCP5 Gene

Q96RT8-GCP5_HUMAN
Tissue specificity: Widely expressed, with highest levels in heart and skeletal muscle and moderate levels in brain.
genes like me logo Genes that share expressions with TUBGCP5: view

Orthologs for TUBGCP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBGCP5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP5 36
  • 99.45 (n)
  • 99.61 (a)
cow
(Bos Taurus)
Mammalia TUBGCP5 36
  • 89.55 (n)
  • 92.09 (a)
dog
(Canis familiaris)
Mammalia TUBGCP5 36
  • 89.78 (n)
  • 92.77 (a)
mouse
(Mus musculus)
Mammalia Tubgcp5 36
  • 87.14 (n)
  • 88.48 (a)
Tubgcp5 16
rat
(Rattus norvegicus)
Mammalia Tubgcp5 36
  • 87.04 (n)
  • 88.87 (a)
chicken
(Gallus gallus)
Aves TUBGCP5 36
  • 78.6 (n)
  • 85.56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18945 36
tubgcp5 36
  • 71.86 (n)
  • 78.42 (a)
zebrafish
(Danio rerio)
Actinopterygii tubgcp5 36
  • 68.82 (n)
  • 73.49 (a)
wufa03b04 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001227 36
  • 41.17 (n)
  • 25.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Grip128 36
  • 42.92 (n)
  • 21.89 (a)
Species with no ortholog for TUBGCP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP5 Gene

ENSEMBL:
Gene Tree for TUBGCP5 (if available)
TreeFam:
Gene Tree for TUBGCP5 (if available)

Paralogs for TUBGCP5 Gene

No data available for Paralogs for TUBGCP5 Gene

Variants for TUBGCP5 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs548 -- 22,999,284(-) TCTTA(C/T)ATTTC utr-variant-3-prime
rs748979 -- 23,018,631(-) TATTG(A/G)TAGCT intron-variant
rs748980 -- 23,018,595(-) AACTT(A/T)AAGTC intron-variant
rs930586 -- 23,039,950(-) GTTCA(C/G)CAGGT upstream-variant-2KB
rs1015172 -- 23,033,097(+) ACGAC(A/G)GAAAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP5 Gene

Variant ID Type Subtype PubMed ID
dgv669e1 CNV Complex 17122850
nsv428296 CNV Gain+Loss 18775914
dgv93e55 CNV Gain 17911159
dgv679e1 CNV Complex 17122850
dgv44n16 CNV Insertion 17901297
esv2751489 CNV Gain 17911159
esv34233 CNV Loss 17911159
essv13315 CNV CNV 17122850
dgv693e1 CNV Complex 17122850
nsv437797 CNV Loss 16327808
dgv695e1 CNV Complex 17122850
esv26683 CNV Gain+Loss 19812545
nsv511042 OTHER Inversion 20534489
nsv433429 CNV Gain 18776910
nsv903495 CNV Gain 21882294
esv2474417 CNV Loss 19546169
nsv442359 CNV CNV 18776908
nsv832924 CNV Loss 17160897
dgv696e1 CNV Complex 17122850
nsv903498 CNV Gain 21882294
dgv2233n71 CNV Gain 21882294
dgv2234n71 CNV Loss 21882294
dgv2235n71 CNV Gain 21882294
dgv2236n71 CNV Gain+Loss 21882294
nsv433290 CNV Loss 18776910
dgv2237n71 CNV Gain 21882294
dgv2238n71 CNV Loss 21882294
dgv2239n71 CNV Gain 21882294
nsv456612 CNV Loss 19166990
dgv287n27 CNV Gain 19166990
nsv471225 CNV Gain 18288195
nsv471226 CNV Loss 18288195
dgv2240n71 CNV Gain 21882294
esv34463 CNV Gain 17911159
essv24027 CNV CNV 17122850
dgv2241n71 CNV Gain 21882294
dgv8n31 CNV Deletion 19718026
nsv1459 CNV Insertion 18451855
nsv9183 CNV Gain+Loss 18304495
dgv2242n71 CNV Gain 21882294
nsv471375 CNV Deletion 19718026
nsv903548 CNV Loss 21882294
nsv456635 CNV Loss 19166990
essv13814 CNV CNV 17122850

Relevant External Links for TUBGCP5 Gene

HapMap Linkage Disequilibrium report
TUBGCP5
Human Gene Mutation Database (HGMD)
TUBGCP5

Disorders for TUBGCP5 Gene

(1) University of Copenhagen DISEASES for TUBGCP5 Gene

genes like me logo Genes that share disorders with TUBGCP5: view

No data available for UniProtKB/Swiss-Prot for TUBGCP5 Gene

Publications for TUBGCP5 Gene

  1. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy S.M. … Stearns T. (Mol. Biol. Cell 2001) 2 3 4
  2. GSK-3beta regulates proper mitotic spindle formation in cooperation with a component of the gamma-tubulin ring complex, GCP5. (PMID: 18316369) Izumi N. … Kikuchi A. (J. Biol. Chem. 2008) 3 23
  3. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. (PMID: 14508708) Chai J.-H. … Nicholls R.D. (Am. J. Hum. Genet. 2003) 3 4

Products for TUBGCP5 Gene

Sources for TUBGCP5 Gene

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