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Aliases for TUBGCP4 Gene

Aliases for TUBGCP4 Gene

  • Tubulin, Gamma Complex Associated Protein 4 2 3
  • GCP4 3 4 6
  • Gamma-Ring Complex Protein 76 KDa 3 4
  • HGrip76 3 4
  • GCP-4 3 4
  • 76P 3 4
  • Gamma Tubulin Ring Complex Protein (76p Gene) 3
  • Gamma-Tubulin Complex Component 4 3
  • Grip76 3
  • HGCP4 4
  • H76p 4

External Ids for TUBGCP4 Gene

Previous GeneCards Identifiers for TUBGCP4 Gene

  • GC15P041451
  • GC15P043663
  • GC15P020511

Summaries for TUBGCP4 Gene

GeneCards Summary for TUBGCP4 Gene

TUBGCP4 (Tubulin, Gamma Complex Associated Protein 4) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is TUBGCP2.

UniProtKB/Swiss-Prot for TUBGCP4 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP4 Gene

Genomics for TUBGCP4 Gene

Regulatory Elements for TUBGCP4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUBGCP4 Gene

Start:
43,369,221 bp from pter
End:
43,409,771 bp from pter
Size:
40,551 bases
Orientation:
Plus strand

Genomic View for TUBGCP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBGCP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP4 Gene

Proteins for TUBGCP4 Gene

  • Protein details for TUBGCP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGJ1-GCP4_HUMAN
    Recommended name:
    Gamma-tubulin complex component 4
    Protein Accession:
    Q9UGJ1
    Secondary Accessions:
    • B3KNK6
    • Q969X3
    • Q9NVF0

    Protein attributes for TUBGCP4 Gene

    Size:
    667 amino acids
    Molecular mass:
    76089 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with NINL.
    SequenceCaution:
    • Sequence=BAA91802.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TUBGCP4 Gene

    Alternative splice isoforms for TUBGCP4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP4 Gene

Proteomics data for TUBGCP4 Gene at MOPED

Post-translational modifications for TUBGCP4 Gene

  • Ubiquitination at Lys358
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBGCP4 Gene

Antibody Products

No data available for DME Specific Peptides for TUBGCP4 Gene

Domains for TUBGCP4 Gene

Protein Domains for TUBGCP4 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for TUBGCP4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UGJ1

UniProtKB/Swiss-Prot:

GCP4_HUMAN :
  • Q9UGJ1
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP4: view

No data available for Gene Families for TUBGCP4 Gene

Function for TUBGCP4 Gene

Molecular function for TUBGCP4 Gene

UniProtKB/Swiss-Prot Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Ontology (GO) - Molecular Function for TUBGCP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton NAS 10562286
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TUBGCP4: view

Phenotypes for TUBGCP4 Gene

GenomeRNAi human phenotypes for TUBGCP4:
genes like me logo Genes that share phenotypes with TUBGCP4: view

Animal Model Products

CRISPR Products

miRNA for TUBGCP4 Gene

miRTarBase miRNAs that target TUBGCP4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBGCP4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBGCP4 Gene

Localization for TUBGCP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP4 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBGCP4 Gene COMPARTMENTS Subcellular localization image for TUBGCP4 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TUBGCP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBGCP4: view

Pathways for TUBGCP4 Gene

genes like me logo Genes that share pathways with TUBGCP4: view

Gene Ontology (GO) - Biological Process for TUBGCP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000226 microtubule cytoskeleton organization --
GO:0000278 mitotic cell cycle TAS --
GO:0006461 protein complex assembly NAS 10562286
GO:0007020 microtubule nucleation NAS 10562286
genes like me logo Genes that share ontologies with TUBGCP4: view

Transcripts for TUBGCP4 Gene

Unigene Clusters for TUBGCP4 Gene

Tubulin, gamma complex associated protein 4:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBGCP4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5:
SP6:
SP7:

ExUns: 19 ^ 20a · 20b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TUBGCP4 Gene

GeneLoc Exon Structure for
TUBGCP4
ECgene alternative splicing isoforms for
TUBGCP4

Expression for TUBGCP4 Gene

mRNA expression in normal human tissues for TUBGCP4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBGCP4 Gene

SOURCE GeneReport for Unigene cluster for TUBGCP4 Gene Hs.584887

mRNA Expression by UniProt/SwissProt for TUBGCP4 Gene

Q9UGJ1-GCP4_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with TUBGCP4: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TUBGCP4 Gene

Orthologs for TUBGCP4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP4 35
  • 99.9 (n)
  • 99.85 (a)
TUBGCP4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBGCP4 35
  • 91.99 (n)
  • 98.95 (a)
TUBGCP4 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBGCP4 35
  • 92.79 (n)
  • 99.1 (a)
TUBGCP4 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubgcp4 35
  • 90.7 (n)
  • 98.35 (a)
Tubgcp4 16
Tubgcp4 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBGCP4 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBGCP4 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubgcp4 35
  • 90.29 (n)
  • 98.5 (a)
chicken
(Gallus gallus)
Aves TUBGCP4 35
  • 80.95 (n)
  • 94.74 (a)
TUBGCP4 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBGCP4 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3574 35
tubgcp4 35
  • 77.04 (n)
  • 92.18 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11204 35
zebrafish
(Danio rerio)
Actinopterygii tubgcp4 35
  • 75.58 (n)
  • 88.89 (a)
tubgcp4 36
  • 89 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008847 35
  • 46.73 (n)
  • 34.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta Grip75 35
  • 42.73 (n)
  • 32.5 (a)
Grip75 36
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 36
  • 10 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GCP4 35
  • 46.88 (n)
  • 36.29 (a)
rice
(Oryza sativa)
Liliopsida Os05g0154500 35
  • 47.31 (n)
  • 35.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for TUBGCP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP4 Gene

ENSEMBL:
Gene Tree for TUBGCP4 (if available)
TreeFam:
Gene Tree for TUBGCP4 (if available)

Paralogs for TUBGCP4 Gene

Paralogs for TUBGCP4 Gene

genes like me logo Genes that share paralogs with TUBGCP4: view

Variants for TUBGCP4 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3883 -- 43,403,518(-) CAGAC(A/G)CACAA intron-variant
rs12299 -- 43,403,514(+) CATTT(G/T)GTGCG intron-variant
rs884704 -- 43,398,952(-) GTGAT(A/G)ATGGC intron-variant
rs884705 -- 43,398,887(-) GACTG(G/T)GATTT intron-variant
rs999025 -- 43,398,102(-) CAGCC(A/G)GATGC synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP4 Gene

Variant ID Type Subtype PubMed ID
nsv1513 CNV Insertion 18451855

Relevant External Links for TUBGCP4 Gene

HapMap Linkage Disequilibrium report
TUBGCP4
Human Gene Mutation Database (HGMD)
TUBGCP4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP4 Gene

Disorders for TUBGCP4 Gene

Relevant External Links for TUBGCP4

Genetic Association Database (GAD)
TUBGCP4
Human Genome Epidemiology (HuGE) Navigator
TUBGCP4
genes like me logo Genes that share disorders with TUBGCP4: view

No data available for UniProtKB/Swiss-Prot for TUBGCP4 Gene

Publications for TUBGCP4 Gene

  1. Human 76p: a new protein member of the gamma-tubulin associated protein family. (PMID: 10562286) Fava F. … Wright M. (J. Cell Biol. 1999) 2 3 4
  2. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy S.M. … Stearns T. (Mol. Biol. Cell 2001) 3 23
  3. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. (PMID: 12852856) Casenghi M. … Nigg E.A. (Dev. Cell 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TUBGCP4 Gene

  • antibodies-online proteins for TUBGCP4
  • antibodies-online antibodies for TUBGCP4
  • antibodies-online kits for TUBGCP4

Sources for TUBGCP4 Gene

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