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TUBGCP4 Gene

protein-coding   GIFtS: 55
GCID: GC15P043663

Tubulin, Gamma Complex Associated Protein 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Gamma Complex Associated Protein 41 2     Grip762
GCP42 3 5     Gamma Tubulin Ring Complex Protein (76p Gene)2
Gamma-Ring Complex Protein 76 KDa2 3     Gamma-Tubulin Complex Component 42
76P2 3     h76p3
GCP-42 3     hGCP43
hGrip762 3     

External Ids:    HGNC: 166911   Entrez Gene: 272292   Ensembl: ENSG000001378227   OMIM: 6096105   UniProtKB: Q9UGJ13   

Export aliases for TUBGCP4 gene to outside databases

Previous GC identifers: GC15P041451 GC15P020511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TUBGCP4 Gene:
TUBGCP4 (tubulin, gamma complex associated protein 4) is a protein-coding gene. Diseases associated with TUBGCP4 include esophageal varix, and genital herpes. GO annotations related to this gene include structural constituent of cytoskeleton. An important paralog of this gene is TUBGCP3.

UniProtKB/Swiss-Prot: GCP4_HUMAN, Q9UGJ1
Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBGCP4 gene promoter:
         GR   C/EBPbeta   GR-beta   NRSF form 2   C/EBPalpha   CHOP-10   PPAR-gamma1   PPAR-gamma2   GR-alpha   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBGCP4 promoter sequence
   Search Chromatin IP Primers for TUBGCP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBGCP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q15   Ensembl cytogenetic band:  15q15.3   HGNC cytogenetic band: 15q15

TUBGCP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBGCP4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P043663:  view genomic region     (about GC identifiers)

Start:
43,661,419 bp from pter      End:
43,699,293 bp from pter
Size:
37,875 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: GCP4_HUMAN, Q9UGJ1 (See protein sequence)
Recommended Name: Gamma-tubulin complex component 4  
Size: 667 amino acids; 76089 Da
Subunit: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
Interacts with NINL
Sequence caution: Sequence=BAA91802.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for TUBGCP4:
3RIP (3D)    
Secondary accessions: B3KNK6 Q969X3 Q9NVF0
Alternative splicing: 2 isoforms:  Q9UGJ1-1   Q9UGJ1-2   

Explore the universe of human proteins at neXtProt for TUBGCP4: NX_Q9UGJ1

Explore proteomics data for TUBGCP4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys358
  • Modification sites at PhosphoSitePlus

  • See TUBGCP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273343.1  NP_055259.2  

    ENSEMBL proteins: 
     ENSP00000454696   ENSP00000260383   ENSP00000456648   ENSP00000455474   ENSP00000455993  
     ENSP00000454915   ENSP00000456550   ENSP00000455555   ENSP00000382387  
    Reactome Protein details: Q9UGJ1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007259 TUBGCP

    Graphical View of Domain Structure for InterPro Entry Q9UGJ1

    ProtoNet protein and cluster: Q9UGJ1

    1 Blocks protein domain: IPB007259 Spc97/Spc98

    UniProtKB/Swiss-Prot: GCP4_HUMAN, Q9UGJ1
    Similarity: Belongs to the TUBGCP family


    TUBGCP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCP4_HUMAN, Q9UGJ1
    Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005200structural constituent of cytoskeleton NAS10562286
         
    TUBGCP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TUBGCP4:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBGCP4
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    miRNA
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    miRTarBase miRNAs that target TUBGCP4:
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    Block miRNA regulation of human, mouse, rat TUBGCP4 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TUBGCP4:
    hsa-miR-2052 hsa-miR-3182 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidTUBGCP4 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GCP4_HUMAN, Q9UGJ1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    endoplasmic reticulum1
    extracellular1
    lysosome1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IEA--
    GO:0005813centrosome IDA--
    GO:0005815microtubule organizing center ----
    GO:0005829cytosol TAS--
    GO:0005874microtubule IEA--

    TUBGCP4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBGCP4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Mitotic G2-G2/M phases0.69
    Centrosome maturation0.86
    Recruitment of NuMA to mitotic centrosomes0.00
    G2/M Transition0.70
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for TUBGCP4
        Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes



    TUBGCP4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBGCP4
    Interactions:

        Search GeneGlobe Interaction Network for TUBGCP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBGCP4 (Q9UGJ12, 3 ENSP000002603834) via UniProtKB, MINT, STRING, and/or I2D (see all 638)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGA2Q083792, 3, ENSP000004160974MINT-66840 I2D: score=4 STRING: ENSP00000416097
    KCTD17Q8N5Z52, 3, ENSP000003843914MINT-68057 I2D: score=4 STRING: ENSP00000384391
    KRT15P190122, 3, ENSP000002540434MINT-66765 I2D: score=4 STRING: ENSP00000254043
    OBFC1Q9H6682, 3, ENSP000002249504MINT-66945 I2D: score=4 STRING: ENSP00000224950
    PAK7Q9P2862, 3, ENSP000003229574MINT-66219 I2D: score=4 STRING: ENSP00000322957
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization ----
    GO:0000278mitotic cell cycle TAS--
    GO:0006461protein complex assembly NAS10562286
    GO:0007020microtubule nucleation NAS10562286

    TUBGCP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TUBGCP4 (GCP4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TUBGCP4 gene (2 alternative transcripts): 
    NM_001286414.1  NM_014444.3  

    Unigene Cluster for TUBGCP4:

    Tubulin, gamma complex associated protein 4
    Hs.584887  [show with all ESTs]
    Unigene Representative Sequence: AK127306
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000570081 ENST00000563517 ENST00000260383 ENST00000564079(uc001zrn.3 uc001zro.3 uc010bdh.3)
    ENST00000561691 ENST00000564511 ENST00000563412 ENST00000563963 ENST00000562053
    ENST00000563147 ENST00000565548 ENST00000566251 ENST00000399460
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TUBGCP4:
    hsa-miR-2052 hsa-miR-3182 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidTUBGCP4 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TUBGCP4

    Additional mRNA sequence: 

    AJ249677.1 AK001639.1 AK026551.1 AK027703.1 AK125173.1 AK127306.1 BC000966.2 BC009870.2 
    BC012801.2 

    14 DOTS entries:

    DT.121049015  DT.116741  DT.92032460  DT.446709  DT.100777974  DT.121049056  DT.100777975  DT.65284705 
    DT.100777976  DT.92014774  DT.97786850  DT.99959691  DT.95219855  DT.97808781 

    Selected AceView cDNA sequences (see all 181):

    AL525772 BE669516 AW197561 BE315167 BQ434560 BF224005 BX350680 BM475379 
    BM791365 AI693358 BU629332 T33250 BF334058 AU132686 BC012801 AL525688 
    AK027703 BQ945967 BM693437 BQ720302 BC000966 BE206999 CA414875 AL525490 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP4 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:                                -                 -           -                       -                                               -                     
    SP2:                                -                 -           -                       -                                               -                     
    SP3:                                                  -           -                       -                                                                     
    SP4:                                                  -           -                                                                                             
    SP5:                                                                                                                                                            

    ExUns: 19 ^ 20a · 20b
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for TUBGCP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBGCP4 expression in normal human tissues (normalized intensities)      TUBGCP4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TUBGCP4 Expression
    About this image


    TUBGCP4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    TUBGCP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBGCP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584887

    UniProtKB/Swiss-Prot: GCP4_HUMAN, Q9UGJ1
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBGCP4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubgcp41 , 5 tubulin, gamma complex associated protein 41, 5 90.7(n)1
    98.35(a)1
      2 (60.37 cM)5
    518851  NM_153387.21  NP_700436.11 
     1211706545 
    chicken
    (Gallus gallus)
    Aves TUBGCP41 tubulin, gamma complex associated protein 4 80.95(n)
    94.74(a)
      415590  XM_413958.4  XP_413958.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUBGCP46
    tubulin, gamma complex associated protein 4
    75(a)
    1 ↔ 1
    GL343941.1(92992-112091)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.35742 Transcribed sequence with moderate similarity to protein more 76.77(n)    AL854371.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tubgcp41 tubulin, gamma complex associated protein 4 75.58(n)
    88.89(a)
      557155  NM_001135130.1  NP_001128602.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Grip751 Grip75 42.73(n)
    32.5(a)
      34441  NM_135568.4  NP_609412.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPC986
    Component of the microtubule-nucleating Tub4p (gam...
    10(a)
    1 → many
    XIV(387227-389767) YNL126W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCP41 GCP4 46.88(n)
    36.29(a)
      824543  NM_115236.3  NP_190944.2 
    rice
    (Oryza sativa)
    Liliopsida Os05g01545001 Os05g0154500 47.31(n)
    35.56(a)
      4337843  NM_001061217.1  NP_001054682.1 


    ENSEMBL Gene Tree for TUBGCP4 (if available)
    TreeFam Gene Tree for TUBGCP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBGCP4 gene
    TUBGCP32  TUBGCP22  

    TUBGCP4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBGCP4 (see all 647)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127790401,2
    F--43664320(+) TTACCC/TGCTTC 1 -- int11Minor allele frequency- T:0.50CSA 2
    rs1883716601,2
    --43664337(+) CAGTAA/GTGTTA 1 -- int10--------
    rs1818262641,2
    --43664387(+) TCTACC/GAGTTA 1 -- int10--------
    rs583566871,2
    C,F--43664588(+) ATGTAT/CTTGGA 1 -- int11Minor allele frequency- C:0.09EA 120
    rs788848021,2
    C--43664694(+) AATTCG/AATGTT 1 -- int12Minor allele frequency- A:0.04CSA WA 120
    rs1449964571,2
    --43664984(+) CATCCC/TCCCCT 1 -- int10--------
    rs1489673611,2
    --43665029(+) CTTGTA/CGGATT 1 -- int10--------
    rs1863968671,2
    --43665045(+) CAATTC/GATAAT 1 -- int10--------
    rs1924227831,2
    --43665250(+) ACATTA/TGAGTA 1 -- int10--------
    rs1436987531,2
    C--43665345(+) CTCAAA/GCATAA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TUBGCP4 (43661419 - 43699293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TUBGCP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1513CNV Insertion18451855

    Human Gene Mutation Database (HGMD): TUBGCP4
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBGCP4
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBGCP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609610    OMIM disorders: --

    5 diseases for TUBGCP4:    About MalaCards
    esophageal varix    genital herpes    esophagitis    breast cancer
    malaria


    TUBGCP4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TUBGCP4
    Human Genome Epidemiology (HuGE) Navigator: TUBGCP4 (1 document)

    Export disorders for TUBGCP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBGCP4 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with TUBGCP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human 76p: a new protein member of the gamma-tubulin associated protein family. (PubMed id 10562286)1, 2, 3 Fava F.... Wright M. (J. Cell Biol. 1999)
    2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. (PubMed id 12852856)1, 2 Casenghi M....Nigg E.A. (Dev. Cell 2003)
    6. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PubMed id 11694571)1, 9 Murphy S.M.... Stearns T. (Mol. Biol. Cell 2001)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27229 HGNC: 16691 AceView: 76P Ensembl:ENSG00000137822 euGenes: HUgn27229
    ECgene: TUBGCP4 H-InvDB: TUBGCP4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TUBGCP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TUBGCP4 gene:
    Search GeneIP for patents involving TUBGCP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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