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Aliases for TUBGCP3 Gene

Aliases for TUBGCP3 Gene

  • Tubulin Gamma Complex Associated Protein 3 2 3 5
  • Spindle Pole Body Protein Spc98 Homolog 3 4
  • Gamma-Ring Complex Protein 104 KDa 3 4
  • GCP3 3 4
  • Tubulin, Gamma Complex Associated Protein 3 2
  • Gamma-Tubulin Complex Component 3 3
  • Spindle Pole Body Protein 2
  • HGrip104 4
  • Grip104 3
  • SPBC98 3
  • Spc98p 3
  • HSpc98 4
  • Spc98 3
  • GCP-3 4
  • H104p 4
  • HGCP3 4
  • 104p 3

External Ids for TUBGCP3 Gene

Previous GeneCards Identifiers for TUBGCP3 Gene

  • GC13M111749
  • GC13M107776
  • GC13M112225
  • GC13M111087
  • GC13M112187
  • GC13M113139
  • GC13M093580

Summaries for TUBGCP3 Gene

GeneCards Summary for TUBGCP3 Gene

TUBGCP3 (Tubulin Gamma Complex Associated Protein 3) is a Protein Coding gene. Diseases associated with TUBGCP3 include Cardiomyopathy, Dilated, 1P. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include structural molecule activity and gamma-tubulin binding. An important paralog of this gene is TUBGCP6.

UniProtKB/Swiss-Prot for TUBGCP3 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP3 Gene

Additional gene information for TUBGCP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP3 Gene

Genomics for TUBGCP3 Gene

Regulatory Elements for TUBGCP3 Gene

Enhancers for TUBGCP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H113206 1.4 ENCODE dbSUPER 114.8 -602.4 -602400 5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC TUBGCP3 PCID2 PROZ GAS6-AS1 GAS6 LINC01043 DCUN1D2-AS SPACA7 LDHBP1 LINC01044
GH13H113296 1.2 ENCODE 66.7 -691.3 -691281 2.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 CDC16 PCID2 TUBGCP3 GAS6-AS2 GAS6 LINC01043 CUL4A SPACA7 LDHBP1 GAS6-AS1
GH13H112586 1.1 ENCODE 33 +18.6 18605 2.8 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF207 TUBGCP3 PCID2 LOC102724489 LINC02337 CUL4A LINC01043 SPACA7 LINC01044 LDHBP1 DCUN1D2-AS
GH13H113489 1.8 FANTOM5 Ensembl ENCODE 19.8 -886.4 -886388 7.5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 TMCO3 TUBGCP3 PCID2 GRTP1 CDC16 DCUN1D2-AS ADPRHL1 CHAMP1 GRTP1-AS1 F7
GH13H113151 1.6 FANTOM5 Ensembl ENCODE 16.3 -547.1 -547090 3.6 MLX ARNT ZFP64 ARID4B DMAP1 ZNF48 YY1 GLIS2 ZNF202 SP5 PCID2 TUBGCP3 F10-AS1 KARSP2 F10 DCUN1D2-AS PROZ CUL4A ATP11A LOC102724474
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Promoters for TUBGCP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066009 42 1200 ELF3 FOXA2 PKNOX1 RB1 ARID4B ZNF2 RAD21 EGR1 ZNF366 ZNF143

Genomic Locations for TUBGCP3 Gene

Genomic Locations for TUBGCP3 Gene
chr13:112,485,005-112,606,442
(GRCh38/hg38)
Size:
121,438 bases
Orientation:
Minus strand
chr13:113,139,325-113,242,481
(GRCh37/hg19)

Genomic View for TUBGCP3 Gene

Genes around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP3 Gene

Proteins for TUBGCP3 Gene

  • Protein details for TUBGCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW5-GCP3_HUMAN
    Recommended name:
    Gamma-tubulin complex component 3
    Protein Accession:
    Q96CW5
    Secondary Accessions:
    • O43631
    • O60852
    • O60853
    • Q5T8L2
    • Q7Z4K1
    • Q96I79

    Protein attributes for TUBGCP3 Gene

    Size:
    907 amino acids
    Molecular mass:
    103571 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.

    Alternative splice isoforms for TUBGCP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP3 Gene

Post-translational modifications for TUBGCP3 Gene

  • Ubiquitination at posLast=220220, Lys276, Lys280, Lys303, and posLast=379379
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBGCP3 Gene

Domains & Families for TUBGCP3 Gene

Gene Families for TUBGCP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUBGCP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96CW5

UniProtKB/Swiss-Prot:

GCP3_HUMAN :
  • Belongs to the TUBGCP family.
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP3: view

Function for TUBGCP3 Gene

Molecular function for TUBGCP3 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Phenotypes From GWAS Catalog for TUBGCP3 Gene

Gene Ontology (GO) - Molecular Function for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 9566967
GO:0005200 structural constituent of cytoskeleton IBA,NAS 9566969
GO:0005515 protein binding IPI 9566969
GO:0043015 gamma-tubulin binding IEA,IDA 9566969
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view
genes like me logo Genes that share phenotypes with TUBGCP3: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP3 Gene

Localization for TUBGCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBGCP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005737 cytoplasm IDA,IEA 9566969
GO:0005813 centrosome NAS 11694571
GO:0005814 centriole IDA 9566969
genes like me logo Genes that share ontologies with TUBGCP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TUBGCP3 Gene

Pathways & Interactions for TUBGCP3 Gene

genes like me logo Genes that share pathways with TUBGCP3: view

Gene Ontology (GO) - Biological Process for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation IEA,NAS 9566969
GO:0007338 single fertilization NAS 9138452
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
GO:0051321 meiotic cell cycle IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view

No data available for SIGNOR curated interactions for TUBGCP3 Gene

Drugs & Compounds for TUBGCP3 Gene

(1) Drugs for TUBGCP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TUBGCP3: view

Transcripts for TUBGCP3 Gene

Unigene Clusters for TUBGCP3 Gene

Tubulin, gamma complex associated protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP3 Gene

No ASD Table

Relevant External Links for TUBGCP3 Gene

GeneLoc Exon Structure for
TUBGCP3
ECgene alternative splicing isoforms for
TUBGCP3

Expression for TUBGCP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBGCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBGCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Testis (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBGCP3 Gene



Protein tissue co-expression partners for TUBGCP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP3 Gene:

TUBGCP3

SOURCE GeneReport for Unigene cluster for TUBGCP3 Gene:

Hs.224152

mRNA Expression by UniProt/SwissProt for TUBGCP3 Gene:

Q96CW5-GCP3_HUMAN
Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for TUBGCP3 Gene

  • Nervous system(4.4)
  • Eye(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with TUBGCP3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBGCP3 Gene

Orthologs for TUBGCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP3 33 34
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia TUBGCP3 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBGCP3 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBGCP3 33 34
  • 86.77 (n)
mouse
(Mus musculus)
Mammalia Tubgcp3 33 16 34
  • 85.08 (n)
cow
(Bos Taurus)
Mammalia TUBGCP3 33 34
  • 81.37 (n)
chicken
(Gallus gallus)
Aves TUBGCP3 33 34
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia TUBGCP3 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp3 33
  • 77.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69134 33
zebrafish
(Danio rerio)
Actinopterygii tubgcp3 33 34
  • 71.65 (n)
wufc09h08 33
fruit fly
(Drosophila melanogaster)
Insecta l(1)dd4 33 34
  • 46.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003865 33
  • 45.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 34 36
  • 16 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SPC98 33
  • 48.11 (n)
rice
(Oryza sativa)
Liliopsida Os09g0446200 33
  • 46.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1647 33
Species where no ortholog for TUBGCP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP3 Gene

ENSEMBL:
Gene Tree for TUBGCP3 (if available)
TreeFam:
Gene Tree for TUBGCP3 (if available)

Paralogs for TUBGCP3 Gene

Paralogs for TUBGCP3 Gene

genes like me logo Genes that share paralogs with TUBGCP3: view

Variants for TUBGCP3 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000005414 -- 112,560,237(+) CATCC(C/T)GGCTA intron-variant
rs1000025970 -- 112,535,281(+) GCGTG(C/T)TTTCA intron-variant
rs1000036519 -- 112,559,917(+) ACCAC(G/T)TGAGG intron-variant
rs1000037656 -- 112,601,892(+) GGTCC(A/G)CACTT intron-variant
rs1000040743 -- 112,567,675(+) CTCCC(A/G)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP3 Gene

Variant ID Type Subtype PubMed ID
nsv820877 CNV duplication 20802225
nsv1053676 CNV gain 25217958
nsv1045238 CNV gain 25217958
nsv1044644 CNV gain 25217958
esv8189 CNV gain 19470904
esv5608 CNV loss 19470904
esv3633580 CNV gain 21293372
esv3580908 CNV loss 25503493
esv3448947 CNV duplication 20981092
esv2748160 CNV deletion 23290073
esv2748159 CNV deletion 23290073
esv2748158 CNV deletion 23290073
esv2748157 CNV deletion 23290073
esv2748156 CNV deletion 23290073
esv2433291 CNV deletion 19546169
esv23229 CNV loss 19812545
esv2222613 CNV deletion 18987734
esv1008083 CNV loss 20482838
dgv3417n54 CNV gain 21841781
dgv1123e59 CNV duplication 20981092
dgv1122e59 CNV duplication 20981092

Variation tolerance for TUBGCP3 Gene

Residual Variation Intolerance Score: 4.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBGCP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBGCP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Disorders for TUBGCP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUBGCP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1p
  • dilated cardiomyopathy 1p
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TUBGCP3

Genetic Association Database (GAD)
TUBGCP3
Human Genome Epidemiology (HuGE) Navigator
TUBGCP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBGCP3
genes like me logo Genes that share disorders with TUBGCP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBGCP3 Gene

Publications for TUBGCP3 Gene

  1. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PMID: 9566969) Tassin AM … Bornens M (The Journal of cell biology 1998) 2 3 4 22 60
  2. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy SM … Stearns T (The Journal of cell biology 1998) 2 3 4 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X … Merdes A (Journal of cell science 2009) 3 22 60
  5. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. (PMID: 17959831) Fong KW … Qi RZ (Molecular biology of the cell 2008) 3 4 60

Products for TUBGCP3 Gene

Sources for TUBGCP3 Gene

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