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Aliases for TUBGCP3 Gene

Aliases for TUBGCP3 Gene

  • Tubulin Gamma Complex Associated Protein 3 2 3 5
  • Spindle Pole Body Protein Spc98 Homolog 3 4
  • Gamma-Ring Complex Protein 104 KDa 3 4
  • GCP3 3 4
  • Tubulin, Gamma Complex Associated Protein 3 2
  • Gamma-Tubulin Complex Component 3 3
  • Spindle Pole Body Protein 2
  • HGrip104 4
  • Grip104 3
  • SPBC98 3
  • Spc98p 3
  • HSpc98 4
  • Spc98 3
  • GCP-3 4
  • H104p 4
  • HGCP3 4
  • 104p 3

External Ids for TUBGCP3 Gene

Previous GeneCards Identifiers for TUBGCP3 Gene

  • GC13M111749
  • GC13M107776
  • GC13M112225
  • GC13M111087
  • GC13M112187
  • GC13M113139
  • GC13M093580

Summaries for TUBGCP3 Gene

GeneCards Summary for TUBGCP3 Gene

TUBGCP3 (Tubulin Gamma Complex Associated Protein 3) is a Protein Coding gene. Diseases associated with TUBGCP3 include Cardiomyopathy, Dilated, 1P. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Chks in Checkpoint Regulation. GO annotations related to this gene include structural molecule activity and gamma-tubulin binding. An important paralog of this gene is TUBGCP2.

UniProtKB/Swiss-Prot for TUBGCP3 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP3 Gene

Genomics for TUBGCP3 Gene

Regulatory Elements for TUBGCP3 Gene

Enhancers for TUBGCP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13G113206 1.4 ENCODE dbSUPER 29.5 -602.4 -602400 5.0 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 TUBGCP3 PROZ GAS6-AS1 LAMP1 PCID2 CUL4A
GH13G113296 1.2 ENCODE 31.1 -691.3 -691281 2.5 MLX CREB3L1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 TUBGCP3 GAS6-AS2 DCUN1D2-AS LAMP1 PIR60275 GC13P113323
GH13G113196 1 ENCODE dbSUPER 20.8 -590.7 -590735 1.5 TSC22D4 ZNF175 YBX1 BCL11B ZFHX2 ZNF366 EGR1 ZNF547 ZNF26 ZSCAN5C PROZ TUBGCP3 DCUN1D2-AS DCUN1D2 CUL4A ENSG00000269125
GH13G112586 1.1 ENCODE 18.6 +18.6 18605 2.8 HNRNPUL1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 TUBGCP3 GC13P112588 GC13P112481
GH13G112573 0.8 Ensembl ENCODE 22.7 +31.6 31550 2.6 CTCF ZNF316 MAFG NFE2 EMSY TUBGCP3 GC13P112588 GC13P112481
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Promoters for TUBGCP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066009 42 1200 PKNOX1 ARID4B ZNF2 ZNF48 ZNF143 DEK SP3 SP5 REST KAT8

Genomic Location for TUBGCP3 Gene

112,485,005 bp from pter
112,606,442 bp from pter
121,438 bases
Minus strand

Genomic View for TUBGCP3 Gene

Genes around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP3 Gene

Proteins for TUBGCP3 Gene

  • Protein details for TUBGCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Gamma-tubulin complex component 3
    Protein Accession:
    Secondary Accessions:
    • O43631
    • O60852
    • O60853
    • Q5T8L2
    • Q7Z4K1
    • Q96I79

    Protein attributes for TUBGCP3 Gene

    907 amino acids
    Molecular mass:
    103571 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.

    Alternative splice isoforms for TUBGCP3 Gene


neXtProt entry for TUBGCP3 Gene

Post-translational modifications for TUBGCP3 Gene

  • Ubiquitination at Lys220, isoforms=2, 3276, Lys280, isoforms=2, 3303, and isoforms=2379
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBGCP3 Gene

Domains & Families for TUBGCP3 Gene

Protein Domains for TUBGCP3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TUBGCP family.
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP3: view

No data available for Gene Families for TUBGCP3 Gene

Function for TUBGCP3 Gene

Molecular function for TUBGCP3 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Ontology (GO) - Molecular Function for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 9566967
GO:0005200 structural constituent of cytoskeleton NAS 9566969
GO:0005515 protein binding IPI 9566969
GO:0043015 gamma-tubulin binding IEA,IDA 9566969
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view
genes like me logo Genes that share phenotypes with TUBGCP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP3 Gene

Localization for TUBGCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBGCP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005737 cytoplasm IDA,IEA 9566969
GO:0005813 centrosome NAS 11694571
GO:0005814 centriole IDA 9566969
genes like me logo Genes that share ontologies with TUBGCP3: view

Pathways & Interactions for TUBGCP3 Gene

genes like me logo Genes that share pathways with TUBGCP3: view

Gene Ontology (GO) - Biological Process for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation NAS,IEA 9566969
GO:0007126 meiotic nuclear division IBA --
GO:0007338 single fertilization NAS 9138452
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view

No data available for SIGNOR curated interactions for TUBGCP3 Gene

Drugs & Compounds for TUBGCP3 Gene

(1) Drugs for TUBGCP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TUBGCP3: view

Transcripts for TUBGCP3 Gene

Unigene Clusters for TUBGCP3 Gene

Tubulin, gamma complex associated protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP3 Gene

No ASD Table

Relevant External Links for TUBGCP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBGCP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBGCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBGCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Testis (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBGCP3 Gene

Protein tissue co-expression partners for TUBGCP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP3 Gene:


SOURCE GeneReport for Unigene cluster for TUBGCP3 Gene:


mRNA Expression by UniProt/SwissProt for TUBGCP3 Gene:

Tissue specificity: Ubiquitously expressed.

Evidence on tissue expression from TISSUES for TUBGCP3 Gene

  • Nervous system(4.4)
  • Eye(4.2)
  • Muscle(4.1)
genes like me logo Genes that share expression patterns with TUBGCP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBGCP3 Gene

Orthologs for TUBGCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TUBGCP3 34 35
  • 99.78 (n)
(Monodelphis domestica)
Mammalia TUBGCP3 35
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia TUBGCP3 35
  • 87 (a)
(Canis familiaris)
Mammalia TUBGCP3 34 35
  • 86.77 (n)
(Mus musculus)
Mammalia Tubgcp3 34 16 35
  • 85.08 (n)
(Bos Taurus)
Mammalia TUBGCP3 34 35
  • 81.37 (n)
(Gallus gallus)
Aves TUBGCP3 34 35
  • 81.24 (n)
(Anolis carolinensis)
Reptilia TUBGCP3 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp3 34
  • 77.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69134 34
(Danio rerio)
Actinopterygii tubgcp3 34 35
  • 71.65 (n)
wufc09h08 34
fruit fly
(Drosophila melanogaster)
Insecta l(1)dd4 34 35
  • 46.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003865 34
  • 45.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 35 37
  • 16 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SPC98 34
  • 48.11 (n)
(Oryza sativa)
Liliopsida Os09g0446200 34
  • 46.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1647 34
Species where no ortholog for TUBGCP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP3 Gene

Gene Tree for TUBGCP3 (if available)
Gene Tree for TUBGCP3 (if available)

Paralogs for TUBGCP3 Gene

Paralogs for TUBGCP3 Gene

genes like me logo Genes that share paralogs with TUBGCP3: view

Variants for TUBGCP3 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000005414 -- 112,560,237(+) CATCC(C/T)GGCTA intron-variant
rs1000025970 -- 112,535,281(+) GCGTG(C/T)TTTCA intron-variant
rs1000036519 -- 112,559,917(+) ACCAC(G/T)TGAGG intron-variant
rs1000037656 -- 112,601,892(+) GGTCC(A/G)CACTT intron-variant
rs1000040743 -- 112,567,675(+) CTCCC(A/G)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP3 Gene

Variant ID Type Subtype PubMed ID
dgv1122e59 CNV duplication 20981092
dgv1123e59 CNV duplication 20981092
dgv3417n54 CNV gain 21841781
esv1008083 CNV loss 20482838
esv2222613 CNV deletion 18987734
esv23229 CNV loss 19812545
esv2433291 CNV deletion 19546169
esv2748156 CNV deletion 23290073
esv2748157 CNV deletion 23290073
esv2748158 CNV deletion 23290073
esv2748159 CNV deletion 23290073
esv2748160 CNV deletion 23290073
esv3448947 CNV duplication 20981092
esv3580908 CNV loss 25503493
esv3633580 CNV gain 21293372
esv5608 CNV loss 19470904
esv8189 CNV gain 19470904
nsv1044644 CNV gain 25217958
nsv1045238 CNV gain 25217958
nsv1053676 CNV gain 25217958
nsv820877 CNV duplication 20802225

Variation tolerance for TUBGCP3 Gene

Residual Variation Intolerance Score: 4.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBGCP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Disorders for TUBGCP3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUBGCP3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1p
  • dilated cardiomyopathy 1p
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TUBGCP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TUBGCP3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBGCP3 Gene

Publications for TUBGCP3 Gene

  1. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy S.M. … Stearns T. (J. Cell Biol. 1998) 2 3 4 22 64
  2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PMID: 9566969) Tassin A.-M. … Bornens M. (J. Cell Biol. 1998) 2 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X. … Merdes A. (J. Cell. Sci. 2009) 3 22 64
  5. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. (PMID: 17959831) Fong K.W. … Qi R.Z. (Mol. Biol. Cell 2008) 3 4 64

Products for TUBGCP3 Gene

Sources for TUBGCP3 Gene

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