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Aliases for TUBGCP3 Gene

Aliases for TUBGCP3 Gene

  • Tubulin Gamma Complex Associated Protein 3 2 3 5
  • Spindle Pole Body Protein Spc98 Homolog 3 4
  • Gamma-Ring Complex Protein 104 KDa 3 4
  • GCP3 3 4
  • Tubulin, Gamma Complex Associated Protein 3 2
  • Gamma-Tubulin Complex Component 3 3
  • Spindle Pole Body Protein 2
  • HGrip104 4
  • Grip104 3
  • SPBC98 3
  • Spc98p 3
  • HSpc98 4
  • Spc98 3
  • GCP-3 4
  • H104p 4
  • HGCP3 4
  • 104p 3

External Ids for TUBGCP3 Gene

Previous GeneCards Identifiers for TUBGCP3 Gene

  • GC13M111749
  • GC13M107776
  • GC13M112225
  • GC13M111087
  • GC13M112187
  • GC13M113139
  • GC13M093580

Summaries for TUBGCP3 Gene

GeneCards Summary for TUBGCP3 Gene

TUBGCP3 (Tubulin Gamma Complex Associated Protein 3) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Chks in Checkpoint Regulation. GO annotations related to this gene include structural molecule activity and gamma-tubulin binding. An important paralog of this gene is TUBGCP2.

UniProtKB/Swiss-Prot for TUBGCP3 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP3 Gene

Genomics for TUBGCP3 Gene

Regulatory Elements for TUBGCP3 Gene

Enhancers for TUBGCP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F113296 0.8 ENCODE 55.3 -691.3 -691281 2.5 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 TUBGCP3 LINC01043 GAS6-AS1 SPACA7 GAS6-AS2 LINC01044 LAMP1 LINC00454 LDHBP1 DCUN1D2-AS
GH13F113206 0.5 ENCODE 37.6 -602.4 -602400 5.0 PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 TUBGCP3 PROZ TMEM255B F10 LINC01043 SPACA7 LINC01044 LINC00454 LDHBP1 GAS6-AS1
GH13F112586 0.4 ENCODE 32.9 +18.6 18605 2.8 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 TUBGCP3 LOC102724489 LOC105370369 LINC01043 F10 SPACA7 LINC01044 LDHBP1 DCUN1D2-AS GC13P112588
GH13F112573 1 Ensembl ENCODE 22.7 +31.4 31442 3.2 OSR2 ZNF121 CTCF ZNF316 MAFG NFE2 EMSY TUBGCP3 GC13P112588 GC13P112481
GH13F112603 0.2 Ensembl 18.9 +2.6 2642 0.4 ZNF263 ZNF341 WT1 TUBGCP3 ATP11AUN ATP11A-AS1 MCF2L ENSG00000277159 GC13P112588
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Promoters for TUBGCP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001512480 42 1200 ELF3 PKNOX1 ARID4B ZNF48 ZNF2 RAD21 ZNF366 ZNF143 RCOR1 EGR2

Genomic Location for TUBGCP3 Gene

Chromosome:
13
Start:
112,485,005 bp from pter
End:
112,606,442 bp from pter
Size:
121,438 bases
Orientation:
Minus strand

Genomic View for TUBGCP3 Gene

Genes around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP3 Gene

Proteins for TUBGCP3 Gene

  • Protein details for TUBGCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW5-GCP3_HUMAN
    Recommended name:
    Gamma-tubulin complex component 3
    Protein Accession:
    Q96CW5
    Secondary Accessions:
    • O43631
    • O60852
    • O60853
    • Q5T8L2
    • Q7Z4K1
    • Q96I79

    Protein attributes for TUBGCP3 Gene

    Size:
    907 amino acids
    Molecular mass:
    103571 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.

    Alternative splice isoforms for TUBGCP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP3 Gene

Post-translational modifications for TUBGCP3 Gene

  • Ubiquitination at Lys 220, Lys 276, Lys 280, Lys 303, and Lys 379
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TUBGCP3

No data available for DME Specific Peptides for TUBGCP3 Gene

Domains & Families for TUBGCP3 Gene

Protein Domains for TUBGCP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96CW5

UniProtKB/Swiss-Prot:

GCP3_HUMAN :
  • Belongs to the TUBGCP family.
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP3: view

No data available for Gene Families for TUBGCP3 Gene

Function for TUBGCP3 Gene

Molecular function for TUBGCP3 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Ontology (GO) - Molecular Function for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 9566967
GO:0005200 structural constituent of cytoskeleton NAS 9566969
GO:0005515 protein binding IPI 9566969
GO:0043015 gamma-tubulin binding IEA,IDA 9566969
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view
genes like me logo Genes that share phenotypes with TUBGCP3: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP3 Gene

Localization for TUBGCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBGCP3 Gene COMPARTMENTS Subcellular localization image for TUBGCP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005737 cytoplasm IEA,IDA 9566969
GO:0005813 centrosome NAS 11694571
GO:0005814 centriole IDA 9566969
genes like me logo Genes that share ontologies with TUBGCP3: view

Pathways & Interactions for TUBGCP3 Gene

genes like me logo Genes that share pathways with TUBGCP3: view

Gene Ontology (GO) - Biological Process for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007020 microtubule nucleation IEA,NAS 9566969
GO:0007126 meiotic nuclear division IBA --
GO:0007338 single fertilization NAS 9138452
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view

No data available for SIGNOR curated interactions for TUBGCP3 Gene

Drugs & Compounds for TUBGCP3 Gene

(1) Drugs for TUBGCP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TUBGCP3: view

Transcripts for TUBGCP3 Gene

Unigene Clusters for TUBGCP3 Gene

Tubulin, gamma complex associated protein 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP3 Gene

No ASD Table

Relevant External Links for TUBGCP3 Gene

GeneLoc Exon Structure for
TUBGCP3
ECgene alternative splicing isoforms for
TUBGCP3

Expression for TUBGCP3 Gene

mRNA expression in normal human tissues for TUBGCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBGCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Testis (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBGCP3 Gene



Protein tissue co-expression partners for TUBGCP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP3 Gene:

TUBGCP3

SOURCE GeneReport for Unigene cluster for TUBGCP3 Gene:

Hs.224152

mRNA Expression by UniProt/SwissProt for TUBGCP3 Gene:

Q96CW5-GCP3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with TUBGCP3: view

Primer Products

No data available for mRNA differential expression in normal tissues for TUBGCP3 Gene

Orthologs for TUBGCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP3 34 35
  • 99.78 (n)
oppossum
(Monodelphis domestica)
Mammalia TUBGCP3 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBGCP3 35
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBGCP3 34 35
  • 86.77 (n)
mouse
(Mus musculus)
Mammalia Tubgcp3 34 16 35
  • 85.08 (n)
cow
(Bos Taurus)
Mammalia TUBGCP3 34 35
  • 81.37 (n)
chicken
(Gallus gallus)
Aves TUBGCP3 34 35
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia TUBGCP3 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp3 34
  • 77.75 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69134 34
zebrafish
(Danio rerio)
Actinopterygii tubgcp3 34 35
  • 71.65 (n)
wufc09h08 34
fruit fly
(Drosophila melanogaster)
Insecta l(1)dd4 34 35
  • 46.57 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003865 34
  • 45.78 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 35 37
  • 16 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons SPC98 34
  • 48.11 (n)
rice
(Oryza sativa)
Liliopsida Os09g0446200 34
  • 46.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1647 34
Species where no ortholog for TUBGCP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP3 Gene

ENSEMBL:
Gene Tree for TUBGCP3 (if available)
TreeFam:
Gene Tree for TUBGCP3 (if available)

Paralogs for TUBGCP3 Gene

Paralogs for TUBGCP3 Gene

genes like me logo Genes that share paralogs with TUBGCP3: view

Variants for TUBGCP3 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs10162039 -- 112,577,696(+) GGGCT(G/T)ACAGG intron-variant
rs1044287 -- 112,556,150(-) TTTAA(C/G)TGCAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1044288 -- 112,556,101(-) CCCAG(C/T)GCTGT nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1044289 -- 112,547,706(-) GAGTA(G/T)TTTAA intron-variant, nc-transcript-variant, reference, missense
rs10492685 -- 112,509,563(-) GTATT(C/T)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP3 Gene

Variant ID Type Subtype PubMed ID
dgv1122e59 CNV duplication 20981092
dgv1123e59 CNV duplication 20981092
dgv3417n54 CNV gain 21841781
esv1008083 CNV loss 20482838
esv2222613 CNV deletion 18987734
esv23229 CNV loss 19812545
esv2433291 CNV deletion 19546169
esv2748156 CNV deletion 23290073
esv2748157 CNV deletion 23290073
esv2748158 CNV deletion 23290073
esv2748159 CNV deletion 23290073
esv2748160 CNV deletion 23290073
esv3448947 CNV duplication 20981092
esv3580908 CNV loss 25503493
esv3633580 CNV gain 21293372
esv5608 CNV loss 19470904
esv8189 CNV gain 19470904
nsv1044644 CNV gain 25217958
nsv1045238 CNV gain 25217958
nsv1053676 CNV gain 25217958
nsv820877 CNV duplication 20802225

Variation tolerance for TUBGCP3 Gene

Residual Variation Intolerance Score: 4.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBGCP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBGCP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Disorders for TUBGCP3 Gene

Relevant External Links for TUBGCP3

Genetic Association Database (GAD)
TUBGCP3
Human Genome Epidemiology (HuGE) Navigator
TUBGCP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBGCP3

No disorders were found for TUBGCP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBGCP3 Gene

Publications for TUBGCP3 Gene

  1. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy S.M. … Stearns T. (J. Cell Biol. 1998) 2 3 4 22 64
  2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PMID: 9566969) Tassin A.-M. … Bornens M. (J. Cell Biol. 1998) 2 3 4 22 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X. … Merdes A. (J. Cell. Sci. 2009) 3 22 64
  5. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. (PMID: 17959831) Fong K.W. … Qi R.Z. (Mol. Biol. Cell 2008) 3 4 64

Products for TUBGCP3 Gene

Sources for TUBGCP3 Gene

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