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Aliases for TUBGCP3 Gene

Aliases for TUBGCP3 Gene

  • Tubulin Gamma Complex Associated Protein 3 2 3 5
  • Tubulin, Gamma Complex Associated Protein 3 2 3
  • Spindle Pole Body Protein Spc98 Homolog 3 4
  • Gamma-Ring Complex Protein 104 KDa 3 4
  • GCP3 3 4
  • Spindle Pole Body Protein 2
  • HGrip104 4
  • Grip104 3
  • SPBC98 3
  • Spc98p 3
  • HSpc98 4
  • Spc98 3
  • GCP-3 4
  • H104p 4
  • HGCP3 4
  • 104p 3

External Ids for TUBGCP3 Gene

Previous GeneCards Identifiers for TUBGCP3 Gene

  • GC13M111749
  • GC13M107776
  • GC13M112225
  • GC13M111087
  • GC13M112187
  • GC13M113139
  • GC13M093580

Summaries for TUBGCP3 Gene

GeneCards Summary for TUBGCP3 Gene

TUBGCP3 (Tubulin Gamma Complex Associated Protein 3) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and G-Beta Gamma Signaling. GO annotations related to this gene include structural molecule activity and gamma-tubulin binding. An important paralog of this gene is TUBGCP2.

UniProtKB/Swiss-Prot for TUBGCP3 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP3 Gene

Genomics for TUBGCP3 Gene

Regulatory Elements for TUBGCP3 Gene

Enhancers for TUBGCP3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Promoters for TUBGCP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBGCP3 Gene

Chromosome:
13
Start:
112,485,005 bp from pter
End:
112,606,442 bp from pter
Size:
121,438 bases
Orientation:
Minus strand

Genomic View for TUBGCP3 Gene

Genes around TUBGCP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP3 Gene

Proteins for TUBGCP3 Gene

  • Protein details for TUBGCP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96CW5-GCP3_HUMAN
    Recommended name:
    Gamma-tubulin complex component 3
    Protein Accession:
    Q96CW5
    Secondary Accessions:
    • O43631
    • O60852
    • O60853
    • Q5T8L2
    • Q7Z4K1
    • Q96I79

    Protein attributes for TUBGCP3 Gene

    Size:
    907 amino acids
    Molecular mass:
    103571 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2.

    Alternative splice isoforms for TUBGCP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP3 Gene

Proteomics data for TUBGCP3 Gene at MOPED

Post-translational modifications for TUBGCP3 Gene

  • Ubiquitination at Lys 220, Lys 276, Lys 280, Lys 303, and Lys 379
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBGCP3 Gene

Antibody Products

No data available for DME Specific Peptides for TUBGCP3 Gene

Domains & Families for TUBGCP3 Gene

Protein Domains for TUBGCP3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96CW5

UniProtKB/Swiss-Prot:

GCP3_HUMAN :
  • Belongs to the TUBGCP family.
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP3: view

No data available for Gene Families for TUBGCP3 Gene

Function for TUBGCP3 Gene

Molecular function for TUBGCP3 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Ontology (GO) - Molecular Function for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity NAS 9566967
GO:0043015 gamma-tubulin binding IDA 9566969
genes like me logo Genes that share ontologies with TUBGCP3: view
genes like me logo Genes that share phenotypes with TUBGCP3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP3 Gene

Localization for TUBGCP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBGCP3 Gene COMPARTMENTS Subcellular localization image for TUBGCP3 gene
Compartment Confidence
cytoskeleton 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005814 centriole IDA 9566969
GO:0005815 microtubule organizing center IEA --
GO:0005819 spindle NAS 7876350
genes like me logo Genes that share ontologies with TUBGCP3: view

Pathways & Interactions for TUBGCP3 Gene

genes like me logo Genes that share pathways with TUBGCP3: view

Gene Ontology (GO) - Biological Process for TUBGCP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007020 microtubule nucleation NAS 9566969
GO:0007126 meiotic nuclear division IBA --
genes like me logo Genes that share ontologies with TUBGCP3: view

No data available for SIGNOR curated interactions for TUBGCP3 Gene

Drugs & Compounds for TUBGCP3 Gene

(1) Drugs for TUBGCP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TUBGCP3: view

Transcripts for TUBGCP3 Gene

Unigene Clusters for TUBGCP3 Gene

Tubulin, gamma complex associated protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP3 Gene

No ASD Table

Relevant External Links for TUBGCP3 Gene

GeneLoc Exon Structure for
TUBGCP3
ECgene alternative splicing isoforms for
TUBGCP3

Expression for TUBGCP3 Gene

mRNA expression in normal human tissues for TUBGCP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBGCP3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.7) and Testis (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBGCP3 Gene



SOURCE GeneReport for Unigene cluster for TUBGCP3 Gene Hs.224152

mRNA Expression by UniProt/SwissProt for TUBGCP3 Gene

Q96CW5-GCP3_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with TUBGCP3: view

Protein tissue co-expression partners for TUBGCP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TUBGCP3 Gene

Orthologs for TUBGCP3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TUBGCP3 35
  • 81.37 (n)
  • 91.62 (a)
TUBGCP3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBGCP3 35
  • 86.77 (n)
  • 93.5 (a)
TUBGCP3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubgcp3 35
  • 85.08 (n)
  • 92.49 (a)
Tubgcp3 16
Tubgcp3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP3 35
  • 99.78 (n)
  • 99.89 (a)
TUBGCP3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBGCP3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBGCP3 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUBGCP3 35
  • 81.24 (n)
  • 91.5 (a)
TUBGCP3 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBGCP3 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp3 35
  • 77.75 (n)
  • 87.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69134 35
zebrafish
(Danio rerio)
Actinopterygii tubgcp3 35
  • 71.65 (n)
  • 79.66 (a)
wufc09h08 35
tubgcp3 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003865 35
  • 45.78 (n)
  • 37.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(1)dd4 35
  • 46.57 (n)
  • 37.58 (a)
l(1)dd4 36
  • 25 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 36
  • 16 (a)
OneToMany
SPC98 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SPC98 35
  • 48.11 (n)
  • 39.2 (a)
rice
(Oryza sativa)
Liliopsida Os09g0446200 35
  • 46.57 (n)
  • 37.43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1647 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for TUBGCP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP3 Gene

ENSEMBL:
Gene Tree for TUBGCP3 (if available)
TreeFam:
Gene Tree for TUBGCP3 (if available)

Paralogs for TUBGCP3 Gene

Paralogs for TUBGCP3 Gene

Pseudogenes.org Pseudogenes for TUBGCP3 Gene

genes like me logo Genes that share paralogs with TUBGCP3: view

Variants for TUBGCP3 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1044287 - 112,556,150(-) TTTAA(C/G)TGCAA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs8381 -- 112,485,254(-) AGTGA(C/T)GAGAA utr-variant-3-prime
rs13791 -- 112,485,295(-) AAATA(A/C)CGCGA utr-variant-3-prime
rs913452 -- 112,488,908(-) TGTGG(A/G)GACCT intron-variant
rs729213 -- 112,522,212(-) TCTTC(A/G)AGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP3 Gene

Variant ID Type Subtype PubMed ID
esv2433291 CNV Deletion 19546169
esv2222613 CNV Deletion 18987734
esv2748156 CNV Deletion 23290073
esv23229 CNV Loss 19812545
nsv820877 CNV Duplication 20802225
esv2748157 CNV Deletion 23290073
esv5608 CNV Loss 19470904
esv2748158 CNV Deletion 23290073
esv2748159 CNV Deletion 23290073
esv1008083 CNV Loss 20482838
esv2748160 CNV Deletion 23290073

Variation tolerance for TUBGCP3 Gene

Residual Variation Intolerance Score: 4.23% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.32; 26.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBGCP3 Gene

HapMap Linkage Disequilibrium report
TUBGCP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP3 Gene

Disorders for TUBGCP3 Gene

Relevant External Links for TUBGCP3

Genetic Association Database (GAD)
TUBGCP3
Human Genome Epidemiology (HuGE) Navigator
TUBGCP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBGCP3

No disorders were found for TUBGCP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBGCP3 Gene

Publications for TUBGCP3 Gene

  1. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PMID: 9566969) Tassin A.-M. … Bornens M. (J. Cell Biol. 1998) 2 3 4 23 67
  2. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy S.M. … Stearns T. (J. Cell Biol. 1998) 2 3 23
  3. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X. … Merdes A. (J. Cell. Sci. 2009) 3 23
  4. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy S.M. … Stearns T. (Mol. Biol. Cell 2001) 3 23
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for TUBGCP3 Gene

Sources for TUBGCP3 Gene

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