Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBGCP3 Gene

protein-coding   GIFtS: 56
GCID: GC13M113139

Tubulin, Gamma Complex Associated Protein 3

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin, Gamma Complex Associated Protein 31 2     hGrip1042 3
Gamma-Ring Complex Protein 104 KDa2 3     hSpc982 3
Spindle Pole Body Protein Spc98 Homolog2 3     Spindle Pole Body Protein1
GCP-32 3     SPBC982
GCP32 3     Spc98p2
h104p2 3     Gamma-Tubulin Complex Component 32
hGCP32 3     

External Ids:    HGNC: 185981   Entrez Gene: 104262   Ensembl: ENSG000001262167   UniProtKB: Q96CW53   

Export aliases for TUBGCP3 gene to outside databases

Previous GC identifers: GC13M111749 GC13M107776 GC13M112225 GC13M111087 GC13M112187 GC13M093580


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TUBGCP3 Gene: 
TUBGCP3 (tubulin, gamma complex associated protein 3) is a protein-coding gene. Diseases associated with TUBGCP3 include mantle cell lymphoma, and infertility, and among its related super-pathways are G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include gamma-tubulin binding and structural molecule activity. An important paralog of this gene is TUBGCP4.

UniProtKB/Swiss-Prot: GCP3_HUMAN, Q96CW5
Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Wiki entry for TUBGCP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_027140.6  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBGCP3 gene promoter:
         GR   PPAR-alpha   GR-alpha   YY1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBGCP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBGCP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBGCP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

TUBGCP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBGCP3 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M113139:  view genomic region     (about GC identifiers)

Start:
113,139,325 bp from pter      End:
113,242,481 bp from pter
Size:
103,157 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GCP3_HUMAN, Q96CW5 (See protein sequence)
Recommended Name: Gamma-tubulin complex component 3  
Size: 907 amino acids; 103571 Da
Subunit: Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6.
Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBGCP3 and CDK5RAP2
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Secondary accessions: O43631 O60852 O60853 Q5T8L2 Q7Z4K1 Q96I79
Alternative splicing: 3 isoforms:  Q96CW5-1   Q96CW5-2   Q96CW5-3   

Explore the universe of human proteins at neXtProt for TUBGCP3: NX_Q96CW5

Explore proteomics data for TUBGCP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96CW5

  • TUBGCP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUBGCP3 Protein Expression
    REFSEQ proteins: NP_006313.1  
    ENSEMBL proteins: 
     ENSP00000261965   ENSP00000364821  
    Reactome Protein details: Q96CW5
    Human Recombinant Protein Products for TUBGCP3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TUBGCP3
    OriGene Protein Over-expression Lysate for TUBGCP3
    OriGene MassSpec for TUBGCP3 
    OriGene Custom Protein Services for TUBGCP3
    GenScript Custom Purified and Recombinant Proteins Services for TUBGCP3
    Novus Biologicals TUBGCP3 Protein
    Novus Biologicals TUBGCP3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole ----
    GO:0005737cytoplasm IDA9566969
    GO:0005813centrosome NAS11694571
    GO:0005814centriole IDA9566969
    GO:0005815microtubule organizing center ----

    TUBGCP3 for ontologies           About GeneDecksing



    TUBGCP3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TUBGCP3
    GenScript Custom Superior Antibodies Services for TUBGCP3
    Novus Biologicals TUBGCP3 Antibodies
    Abcam antibodies for TUBGCP3
    Browse Antibodies at Cloud-Clone Corp. 
    Search ThermoFisher Antibodies for TUBGCP3
    LSBio Antibodies in human, mouse, rat for TUBGCP3 

    Assay Products for TUBGCP3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TUBGCP3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TUBGCP3
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR015697 GCP3
     IPR007259 Spc97_Spc98

    Graphical View of Domain Structure for InterPro Entry Q96CW5

    ProtoNet protein and cluster: Q96CW5

    1 Blocks protein domain: IPB007259 Spc97/Spc98

    UniProtKB/Swiss-Prot: GCP3_HUMAN, Q96CW5
    Similarity: Belongs to the TUBGCP family


    TUBGCP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GCP3_HUMAN, Q96CW5
    Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005198structural molecule activity NAS9566967
    GO:0005200structural constituent of cytoskeleton NAS9566969
    GO:0005515protein binding IPI17959831
    GO:0043015gamma-tubulin binding IDA9566969
         
    TUBGCP3 for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for TUBGCP3:
     Decreased viability of wild-ty  Decreased viability with pacli  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUBGCP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TUBGCP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBGCP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUBGCP3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBGCP3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TUBGCP3 (see all 16):
    hsa-miR-30c hsa-miR-495 hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-30d hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidTUBGCP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TUBGCP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBGCP3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TUBGCP3
    Sirion Biotech Customized adenovirus for overexpression of TUBGCP3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TUBGCP3 (see all 8)
    OriGene ORF clones in mouse, rat for TUBGCP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBGCP3 (NM_006322)
    Sino Biological Human cDNA Clone for TUBGCP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBGCP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBGCP3
    Sirion Biotech Customized lentivirus for stable overexpression of TUBGCP3 
                         Customized lentivirus expression plasmids for stable overexpression of TUBGCP3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TUBGCP3
    Search LifeMap BioReagents cell lines for TUBGCP3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUBGCP3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    G2/M Transition0.83
    Centrosome maturation0.83
    Mitotic G2-G2/M phases0.81
    2Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    3Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    4Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
    Recruitment of NuMA to mitotic centrosomes0.50
    5G-Beta Gamma Signaling
    Hedgehog Signaling in Mammals0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TUBGCP3
        14-3-3 Induced Intracellular Signaling
    Hedgehog Signaling in Mammals
    Parkinson's Disease Pathway


    5/7        Reactome Pathways for TUBGCP3 (see all 7)
        Centrosome maturation
    G2/M Transition
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    Mitotic G2-G2/M phases



    TUBGCP3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUBGCP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/858 Interacting proteins for TUBGCP3 (Q96CW52, 3 ENSP000002619654) via UniProtKB, MINT, STRING, and/or I2D (see all 858)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNTO956132, 3, ENSP000003525724MINT-7947479 I2D: score=3 STRING: ENSP00000352572
    IMMTQ168912, 3, ENSP000003872624MINT-8276031 I2D: score=2 STRING: ENSP00000387262
    TUBG1P232582, 3, ENSP000002514134MINT-7945693 MINT-7947479 I2D: score=5 STRING: ENSP00000251413
    TUBGCP2Q9BSJ22, 3, ENSP000002529364MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000252936
    CKAP5Q140082, ENSP000003465664MINT-7945693 MINT-7947479 STRING: ENSP00000346566
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization ----
    GO:0000278mitotic cell cycle TAS--
    GO:0007020microtubule nucleation NAS11694571
    GO:0007338single fertilization NAS9138452

    TUBGCP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TUBGCP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TUBGCP3 (GCP3)

    1 Novoseek inferred chemical compound relationship for TUBGCP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sucrose 36.2 1 9566967 (1)

    Search CenterWatch for drugs/clinical trials and news about TUBGCP3 / GCP3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUBGCP3 gene: 
    NM_006322.4  

    Unigene Cluster for TUBGCP3:

    Tubulin, gamma complex associated protein 3
    Hs.224152  [show with all ESTs]
    Unigene Representative Sequence: BC046634
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261965(uc001vse.1 uc010tjq.1) ENST00000469302 ENST00000375669(uc001vsf.3)
    ENST00000462580 ENST00000464139(uc001vsg.1) ENST00000483532

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBGCP3
    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate TUBGCP3 (see all 16):
    hsa-miR-30c hsa-miR-495 hsa-miR-520d-5p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-30d hsa-miR-410
    SwitchGear 3'UTR luciferase reporter plasmidTUBGCP3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TUBGCP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBGCP3
    Clone
    Products:
         
    OriGene clones in human, mouse for TUBGCP3 (see all 8)
    OriGene ORF clones in mouse, rat for TUBGCP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBGCP3 (NM_006322)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBGCP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBGCP3
    Sirion Biotech Customized lentivirus for stable overexpression of TUBGCP3 
                         Customized lentivirus expression plasmids for stable overexpression of TUBGCP3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TUBGCP3
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBGCP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUBGCP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBGCP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBGCP3

    Additional mRNA sequence: 

    AF042378.1 AJ003061.1 AJ003062.1 AK302537.1 AK314785.1 BC007763.2 BC013781.1 BC046634.2 
    BT009772.1 L13800.1 L13801.1 

    11 DOTS entries:

    DT.113239  DT.100788660  DT.100788666  DT.40121013  DT.95179955  DT.95214519  DT.100788662  DT.120763339 
    DT.91886396  DT.95179958  DT.95363972 

    24/154 AceView cDNA sequences (see all 154):

    BT009772 BU527799 BQ223303 CA392672 BQ438247 BU742889 BC013781 CD676051 
    BM474805 AI821622 AF042378 AA233670 AI268652 AL703466 BM479981 L13801 
    BU630764 Z45067 AA720688 CR616288 CK818925 BU623732 AJ003062 AU131434 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBGCP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAATGAAG
    TUBGCP3 Expression
    About this image


    See TUBGCP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUBGCP3

    SOURCE GeneReport for Unigene cluster: Hs.224152

    UniProtKB/Swiss-Prot: GCP3_HUMAN, Q96CW5
    Tissue specificity: Ubiquitously expressed

        SABiosciences Custom PCR Arrays for TUBGCP3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUBGCP3
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBGCP3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUBGCP3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBGCP3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBGCP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBGCP3 gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubgcp31 , 5 tubulin, gamma complex associated protein 31, 5 85.93(n)1
    93.81(a)1
      8 (5.73 cM)5
    2592791  NM_198031.11  NP_932148.11 
     126142775 
    chicken
    (Gallus gallus)
    Aves TUBGCP31 tubulin, gamma complex associated protein 3 81.24(n)
    91.5(a)
      418750  XM_416949.3  XP_416949.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUBGCP36
    Uncharacterized protein
    86(a)
    1 ↔ 1
    3(105515703-105584701)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC691342 hypothetical protein MGC69134 78.75(n)    BC057755.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc09h082 Transcribed sequence with moderate similarity to protein more 75.97(n)    BI476157.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(1)dd41 lethal (1) discs degenerate 4 46.32(n)
    37.42(a)
      48481  NM_080180.3  NP_524919.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SPC981 spindle pole body component 98 47.87(n)
    39.24(a)
      830557  NM_120751.3  NP_196286.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04462001 hypothetical protein 46.39(n)
    37.04(a)
      4347202  NM_001069843.2  NP_001063308.2 


    ENSEMBL Gene Tree for TUBGCP3 (if available)
    TreeFam Gene Tree for TUBGCP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBGCP3 gene
    TUBGCP42  TUBGCP22  

    TUBGCP3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TUBGCP3
    PGOHUM00000248685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2249 SNPs in TUBGCP3 are shown (see all 2249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs95501161,2
    C,A--94077588(+) CTCTCC/TGAATA 1 -- int14Minor allele frequency- T:0.12NA 8
    rs735645911,2
    C,F--94077643(+) CTCTCG/ATGGAG 1 -- int12Minor allele frequency- A:0.04WA 120
    rs1837539381,2
    --94077655(+) TAAACA/GATATG 1 -- int10--------
    rs1174357841,2
    F--94077718(+) TTTATG/CAACTT 1 -- int11Minor allele frequency- C:0.02EA 120
    rs1883892221,2
    --94077723(+) GAACTG/TCAAAA 1 -- int10--------
    rs802407451,2
    F--94077876(+) GACCTG/AAGCGG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1419920671,2
    --94077881(+) GAGCGA/GTGACA 1 -- int10--------
    rs118401571,2
    H--94077899(+) TGCTTC/GTATAC 1 -- int10--------
    rs1509016531,2
    --94077901(+) CTTCTA/GTACCA 1 -- int10--------
    rs784137981,2
    C,F--94078051(+) CGAATG/ACATCT 1 -- int11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for TUBGCP3 (113139325 - 113242481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for TUBGCP3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748159CNV Deletion23290073
    esv2222613CNV Deletion18987734
    esv2433291CNV Deletion19546169
    esv2748160CNV Deletion23290073
    esv2748157CNV Deletion23290073
    esv2748156CNV Deletion23290073
    esv2748158CNV Deletion23290073
    nsv820877CNV Duplication20802225
    esv1008083CNV Loss20482838
    esv23229CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBGCP3
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBGCP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for TUBGCP3:    About MalaCards
    mantle cell lymphoma    infertility    parkinson's disease


    TUBGCP3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TUBGCP3
    Human Genome Epidemiology (HuGE) Navigator: TUBGCP3 (2 documents)

    Export disorders for TUBGCP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBGCP3 gene, integrated from 9 sources (see all 35):
    (articles sorted by number of sources associating them with TUBGCP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PubMed id 9566969)1, 2, 3, 9 Tassin A.-M.... Bornens M. (1998)
    2. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PubMed id 9566967)1, 2, 3, 9 Murphy S.M.... Stearns T. (1998)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. (PubMed id 17959831)1, 2 Fong K.W....Qi R.Z. (2008)
    5. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PubMed id 19299467)1, 9 Fant X....Merdes A. (2009)
    8. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PubMed id 11694571)1, 9 Murphy S.M.... Stearns T. (2001)
    9. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    10. Functional replacement of fission yeast g-tubulin smal l complex proteins Alp4 and Alp6 by human GCP2 and GCP3. (PubMed id 23886939)1 Riehlman T.D....Paluh J.L. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10426 HGNC: 18598 AceView: TUBGCP3 Ensembl:ENSG00000126216 euGenes: HUgn10426
    ECgene: TUBGCP3 H-InvDB: TUBGCP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBGCP3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUBGCP3 gene:
    Search GeneIP for patents involving TUBGCP3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TUBGCP3  
     OriGene qPCR primer pairs and template standards for TUBGCP3   OriGene Protein Over-expression Lysate for TUBGCP3  
     OriGene MassSpec something-or-other for TUBGCP3   OriGene clones in human, mouse for TUBGCP3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TUBGCP3   OriGene Purified Protein for TUBGCP3  
     OriGene ORF clones in mouse, rat for TUBGCP3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TUBGCP3   OriGene Custom Protein Services for TUBGCP3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUBGCP3
     QIAGEN SeqTarget long-range PCR primers for resequencing TUBGCP3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBGCP3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBGCP3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBGCP3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBGCP3
     GenScript Custom Purified and Recombinant Proteins Services for TUBGCP3 GenScript cDNA clones with any tag delivered in your preferred vector for TUBGCP3
     GenScript Custom Assay Services for TUBGCP3 GenScript Custom Superior Antibodies Services for TUBGCP3
     GenScript Custom overexpressing Cell Line Services for TUBGCP3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TUBGCP3 promoter
     Search Chromatin IP Primers for TUBGCP3
     RT2 qPCR Primer Assay in human, mouse, rat TUBGCP3
     GNC Network for TUBGCP3
     SABiosciences PCR Arrays including human, mouse, rat TUBGCP3
     Search Tocris compounds for TUBGCP3 (GCP3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for TUBGCP3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TUBGCP3 antibodies
     TUBGCP3 proteins
     TUBGCP3 lysates
     Antibodies for TUBGCP3
     See all of Abcam's Antibodies, Kits and Proteins for TUBGCP3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.
     Search LifeMap BioReagents cell lines for TUBGCP3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBGCP3
     SwitchGear 3'UTR luciferase reporter plasmids for TUBGCP3
     SwitchGear Promoter luciferase reporter plasmids for TUBGCP3
     Search ThermoFisher Antibodies for TUBGCP3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBGCP3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TUBGCP3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TUBGCP3
    Customized:
     lentivirus for stable overexpression of TUBGCP3
     lentivirus expression plasmids for stable overexpression of TUBGCP3
     adenovirus for overexpression of TUBGCP3
     LSBio Antibodies in human, mouse, rat for TUBGCP3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TUBGCP3 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4