Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TUBGCP2 Gene

Aliases for TUBGCP2 Gene

  • Tubulin Gamma Complex Associated Protein 2 2 3 5
  • Spindle Pole Body Protein Spc97 Homolog 3 4
  • Gamma-Ring Complex Protein 103 KDa 3 4
  • HGrip103 3 4
  • HSpc97 3 4
  • GCP-2 3 4
  • H103p 3 4
  • HGCP2 3 4
  • GCP2 3 4
  • Tubulin, Gamma Complex Associated Protein 2 2
  • Gamma-Tubulin Complex Component 2 3
  • Grip103 3
  • SPBC97 3
  • Spc97p 3

External Ids for TUBGCP2 Gene

Previous GeneCards Identifiers for TUBGCP2 Gene

  • GC10M134007
  • GC10M134223
  • GC10M135009
  • GC10M134566
  • GC10M134982
  • GC10M134943
  • GC10M135094
  • GC10M128639

Summaries for TUBGCP2 Gene

GeneCards Summary for TUBGCP2 Gene

TUBGCP2 (Tubulin Gamma Complex Associated Protein 2) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. An important paralog of this gene is TUBGCP3.

UniProtKB/Swiss-Prot for TUBGCP2 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Wiki entry for TUBGCP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP2 Gene

Genomics for TUBGCP2 Gene

Regulatory Elements for TUBGCP2 Gene

Enhancers for TUBGCP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TUBGCP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBGCP2 Gene

Chromosome:
10
Start:
133,278,630 bp from pter
End:
133,312,337 bp from pter
Size:
33,708 bases
Orientation:
Minus strand

Genomic View for TUBGCP2 Gene

Genes around TUBGCP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBGCP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBGCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP2 Gene

Proteins for TUBGCP2 Gene

  • Protein details for TUBGCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSJ2-GCP2_HUMAN
    Recommended name:
    Gamma-tubulin complex component 2
    Protein Accession:
    Q9BSJ2
    Secondary Accessions:
    • B4DM18
    • B7ZKL8
    • F5H4E0
    • F5H4L0
    • O43632
    • Q5VWX7

    Protein attributes for TUBGCP2 Gene

    Size:
    902 amino acids
    Molecular mass:
    102534 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6. Interacts with ATF5; the ATF5:PCNT:polyglutamylated tubulin (PGT) tripartite unites the mother centriole and the pericentriolar material (PCM) in the centrosome (PubMed:26213385).
    SequenceCaution:
    • Sequence=BC005011; Type=Frameshift; Positions=513; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP2 Gene

Post-translational modifications for TUBGCP2 Gene

  • Ubiquitination at Lys 157 and Lys 455
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBGCP2 Gene

Domains & Families for TUBGCP2 Gene

Protein Domains for TUBGCP2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BSJ2

UniProtKB/Swiss-Prot:

GCP2_HUMAN :
  • Belongs to the TUBGCP family.
Family:
  • Belongs to the TUBGCP family.
genes like me logo Genes that share domains with TUBGCP2: view

No data available for Gene Families for TUBGCP2 Gene

Function for TUBGCP2 Gene

Molecular function for TUBGCP2 Gene

UniProtKB/Swiss-Prot Function:
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

Gene Ontology (GO) - Molecular Function for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IBA --
GO:0005515 protein binding IPI 16980960
GO:0043015 gamma-tubulin binding IBA --
GO:0051011 contributes_to microtubule minus-end binding IBA --
genes like me logo Genes that share ontologies with TUBGCP2: view
genes like me logo Genes that share phenotypes with TUBGCP2: view

Animal Model Products

CRISPR Products

miRNA for TUBGCP2 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBGCP2 Gene

Localization for TUBGCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBGCP2 Gene COMPARTMENTS Subcellular localization image for TUBGCP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000923 equatorial microtubule organizing center IBA --
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA 21399614
GO:0005815 microtubule organizing center TAS 9566967
GO:0005816 NOT spindle pole body IBA --
genes like me logo Genes that share ontologies with TUBGCP2: view

Pathways & Interactions for TUBGCP2 Gene

genes like me logo Genes that share pathways with TUBGCP2: view

Gene Ontology (GO) - Biological Process for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006461 protein complex assembly TAS 9566967
GO:0007020 microtubule nucleation TAS 9566967
GO:0007126 meiotic nuclear division IBA --
GO:0031122 cytoplasmic microtubule organization IBA --
GO:0051298 centrosome duplication IBA --
genes like me logo Genes that share ontologies with TUBGCP2: view

No data available for SIGNOR curated interactions for TUBGCP2 Gene

Drugs & Compounds for TUBGCP2 Gene

(1) Drugs for TUBGCP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TUBGCP2: view

Transcripts for TUBGCP2 Gene

Unigene Clusters for TUBGCP2 Gene

Tubulin, gamma complex associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
SP1: - - - - - - - - -
SP2:
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11: - - - - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18: - - -
SP19: -
SP20:
SP21:

ExUns: 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13: -
SP14: - -
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for TUBGCP2 Gene

GeneLoc Exon Structure for
TUBGCP2
ECgene alternative splicing isoforms for
TUBGCP2

Expression for TUBGCP2 Gene

mRNA expression in normal human tissues for TUBGCP2 Gene

Protein differential expression in normal tissues from HIPED for TUBGCP2 Gene

This gene is overexpressed in Bone (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBGCP2 Gene



Protein tissue co-expression partners for TUBGCP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBGCP2 Gene:

TUBGCP2

SOURCE GeneReport for Unigene cluster for TUBGCP2 Gene:

Hs.523370

mRNA Expression by UniProt/SwissProt for TUBGCP2 Gene:

Q9BSJ2-GCP2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with TUBGCP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TUBGCP2 Gene

Orthologs for TUBGCP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TUBGCP2 34
  • 85.74 (n)
  • 89.47 (a)
TUBGCP2 35
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBGCP2 34
  • 87.23 (n)
  • 89.94 (a)
TUBGCP2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubgcp2 34
  • 86.4 (n)
  • 91.24 (a)
Tubgcp2 16
Tubgcp2 35
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP2 34
  • 96.02 (n)
  • 95.83 (a)
TUBGCP2 35
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubgcp2 34
  • 86.36 (n)
  • 91.46 (a)
oppossum
(Monodelphis domestica)
Mammalia TUBGCP2 35
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBGCP2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUBGCP2 34
  • 76.29 (n)
  • 85.17 (a)
TUBGCP2 35
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBGCP2 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp2 34
  • 71.38 (n)
  • 78.96 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 34
tubgcp2 34
  • 73.37 (n)
  • 78.98 (a)
tubgcp2 35
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005575 34
  • 54.38 (n)
  • 39.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta Grip84 34
  • 53.15 (n)
  • 38.71 (a)
CG7716 35
  • 23 (a)
OneToMany
Grip84 35
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC98 35
  • 13 (a)
OneToMany
SPC97 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17410 34
  • 47.39 (n)
  • 41.67 (a)
rice
(Oryza sativa)
Liliopsida Os04g0501700 34
  • 46.45 (n)
  • 38.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3710 35
  • 46 (a)
OneToOne
Species where no ortholog for TUBGCP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP2 Gene

ENSEMBL:
Gene Tree for TUBGCP2 (if available)
TreeFam:
Gene Tree for TUBGCP2 (if available)

Paralogs for TUBGCP2 Gene

Paralogs for TUBGCP2 Gene

genes like me logo Genes that share paralogs with TUBGCP2: view

Variants for TUBGCP2 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs2298121 - 133,299,552(+) AGCAG(C/T)GGCTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11101682 - 133,297,990(+) CACCA(A/G)TCAGG nc-transcript-variant, reference, missense
rs11101677 - 133,281,421(+) GTCTG(A/C/T)GTGCT nc-transcript-variant, reference, missense
rs3747887 -- 133,282,972(-) GTGTT(C/T)GTGGA intron-variant
rs3747888 -- 133,281,472(-) TGGGG(A/G)TGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP2 Gene

Variant ID Type Subtype PubMed ID
dgv122n27 CNV loss 19166990
dgv1475n54 CNV loss 21841781
dgv1476n54 CNV gain 21841781
dgv1477n54 CNV gain+loss 21841781
dgv1478n54 CNV gain+loss 21841781
dgv1479n54 CNV loss 21841781
dgv1480n54 CNV gain 21841781
dgv1481n54 CNV loss 21841781
dgv2e196 CNV duplication 17116639
dgv3e196 CNV duplication 17116639
esv23338 CNV gain+loss 19812545
esv2536519 CNV deletion 19546169
esv2750853 CNV gain 17911159
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv2894 CNV loss 18987735
esv3547149 CNV deletion 23714750
esv3625030 CNV gain 21293372
esv3625039 CNV loss 21293372
esv3625040 CNV gain 21293372
esv3891901 CNV loss 25118596
esv7552 CNV loss 19470904
esv988628 CNV insertion 20482838
nsv1037772 CNV gain 25217958
nsv1040726 CNV loss 25217958
nsv1052904 CNV gain 25217958
nsv1069102 CNV deletion 25765185
nsv1076103 CNV deletion 25765185
nsv1113353 CNV deletion 24896259
nsv1147942 CNV deletion 26484159
nsv1159785 CNV deletion 26073780
nsv1159786 CNV deletion 26073780
nsv428243 CNV gain 18775914
nsv470980 CNV loss 18288195
nsv509381 CNV insertion 20534489
nsv512195 CNV loss 21212237
nsv528260 CNV loss 19592680
nsv552587 CNV loss 21841781
nsv552589 CNV gain 21841781
nsv552590 CNV loss 21841781
nsv552599 CNV loss 21841781
nsv552615 CNV gain+loss 21841781
nsv552616 CNV gain 21841781
nsv552617 CNV loss 21841781
nsv552618 CNV gain 21841781
nsv552621 CNV loss 21841781
nsv552622 CNV loss 21841781
nsv552623 CNV loss 21841781
nsv819663 CNV loss 19587683
nsv832036 CNV loss 17160897
nsv832038 CNV gain+loss 17160897
nsv832040 CNV loss 17160897
nsv952705 CNV deletion 24416366

Variation tolerance for TUBGCP2 Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBGCP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBGCP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBGCP2 Gene

Disorders for TUBGCP2 Gene

Relevant External Links for TUBGCP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBGCP2

No disorders were found for TUBGCP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBGCP2 Gene

Publications for TUBGCP2 Gene

  1. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy S.M. … Stearns T. (J. Cell Biol. 1998) 2 3 4 22 65
  2. ATF5 Connects the Pericentriolar Materials to the Proximal End of the Mother Centriole. (PMID: 26213385) Madarampalli B. … Liu D.X. (Cell 2015) 3 4 65
  3. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X. … Merdes A. (J. Cell. Sci. 2009) 3 22 65
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for TUBGCP2 Gene

Sources for TUBGCP2 Gene

Content