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Aliases for TUBGCP2 Gene

Aliases for TUBGCP2 Gene

  • Tubulin, Gamma Complex Associated Protein 2 2 3
  • Spindle Pole Body Protein Spc97 Homolog 3 4
  • Gamma-Ring Complex Protein 103 KDa 3 4
  • HGrip103 3 4
  • HSpc97 3 4
  • GCP-2 3 4
  • H103p 3 4
  • HGCP2 3 4
  • GCP2 3 4
  • Gamma-Tubulin Complex Component 2 3
  • Grip103 3
  • SPBC97 3
  • Spc97p 3

External Ids for TUBGCP2 Gene

Summaries for TUBGCP2 Gene

GeneCards Summary for TUBGCP2 Gene

TUBGCP2 (Tubulin, Gamma Complex Associated Protein 2) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Cell Cycle, Mitotic. An important paralog of this gene is TUBGCP4.

UniProtKB/Swiss-Prot for TUBGCP2 Gene

  • Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Wiki entry for TUBGCP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBGCP2 Gene

Genomics for TUBGCP2 Gene

Genomic Location for TUBGCP2 Gene

Start:
133,278,630 bp from pter
End:
133,312,337 bp from pter
Size:
33,708 bases
Orientation:
Minus strand

Genomic View for TUBGCP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBGCP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBGCP2 Gene

Proteins for TUBGCP2 Gene

  • Protein details for TUBGCP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSJ2-GCP2_HUMAN
    Recommended name:
    Gamma-tubulin complex component 2
    Protein Accession:
    Q9BSJ2
    Secondary Accessions:
    • B4DM18
    • B7ZKL8
    • F5H4E0
    • F5H4L0
    • O43632
    • Q5VWX7

    Protein attributes for TUBGCP2 Gene

    Size:
    902 amino acids
    Molecular mass:
    102534 Da
    Quaternary structure:
    • Gamma-tubulin complex is composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6
    SequenceCaution:
    • Sequence=BC005011; Type=Frameshift; Positions=513; Evidence={ECO:0000305};

    Alternative splice isoforms for TUBGCP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBGCP2 Gene

Proteomics data for TUBGCP2 Gene at MOPED

Post-translational modifications for TUBGCP2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys157 and Lys455

Other Protein References for TUBGCP2 Gene

No data available for DME Specific Peptides for TUBGCP2 Gene

Domains for TUBGCP2 Gene

Protein Domains for TUBGCP2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

GCP2_HUMAN
Family:
  • Belongs to the TUBGCP family.:
    • Q9BSJ2
genes like me logo Genes that share domains with TUBGCP2: view

No data available for Gene Families for TUBGCP2 Gene

Function for TUBGCP2 Gene

Molecular function for TUBGCP2 Gene

UniProtKB/Swiss-Prot Function: Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome

Gene Ontology (GO) - Molecular Function for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16980960
genes like me logo Genes that share ontologies with TUBGCP2: view

Phenotypes for TUBGCP2 Gene

GenomeRNAi human phenotypes for TUBGCP2:
genes like me logo Genes that share phenotypes with TUBGCP2: view

miRNA for TUBGCP2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBGCP2 Gene

Localization for TUBGCP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBGCP2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBGCP2 Gene COMPARTMENTS Subcellular localization image for TUBGCP2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IEA --
GO:0005654 nucleoplasm IDA --
GO:0005813 centrosome IDA --
GO:0005815 microtubule organizing center TAS 9566967
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TUBGCP2: view

Pathways for TUBGCP2 Gene

genes like me logo Genes that share pathways with TUBGCP2: view

Gene Ontology (GO) - Biological Process for TUBGCP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000226 microtubule cytoskeleton organization --
GO:0000278 mitotic cell cycle TAS --
GO:0006461 protein complex assembly TAS 9566967
GO:0007020 microtubule nucleation TAS 9566967
genes like me logo Genes that share ontologies with TUBGCP2: view

Compounds for TUBGCP2 Gene

(1) Novoseek inferred chemical compound relationships for TUBGCP2 Gene

Compound -log(P) Hits PubMed IDs
sucrose 29.6 1
genes like me logo Genes that share compounds with TUBGCP2: view

Transcripts for TUBGCP2 Gene

Unigene Clusters for TUBGCP2 Gene

Tubulin, gamma complex associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBGCP2 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11a · 11b ^ 12a ·
SP1: - - - - - - - - -
SP2:
SP3: - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: -
SP8:
SP9:
SP10:
SP11: - - - - -
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18: - - -
SP19: -
SP20:
SP21:

ExUns: 12b · 12c ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18a · 18b · 18c ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25a · 25b
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - -
SP9:
SP10: -
SP11:
SP12:
SP13: -
SP14: - -
SP15: -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for TUBGCP2 Gene

GeneLoc Exon Structure for
TUBGCP2
ECgene alternative splicing isoforms for
TUBGCP2

Expression for TUBGCP2 Gene

mRNA expression in normal human tissues for TUBGCP2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBGCP2 Gene

SOURCE GeneReport for Unigene cluster for TUBGCP2 Gene Hs.523370

mRNA Expression by UniProt/SwissProt for TUBGCP2 Gene

Q9BSJ2-GCP2_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with TUBGCP2: view

Orthologs for TUBGCP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBGCP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBGCP2 36
  • 96.02 (n)
  • 95.83 (a)
TUBGCP2 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBGCP2 36
  • 85.74 (n)
  • 89.47 (a)
TUBGCP2 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBGCP2 36
  • 87.23 (n)
  • 89.94 (a)
TUBGCP2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubgcp2 36
  • 86.4 (n)
  • 91.24 (a)
Tubgcp2 16
Tubgcp2 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBGCP2 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBGCP2 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubgcp2 36
  • 86.36 (n)
  • 91.46 (a)
chicken
(Gallus gallus)
Aves TUBGCP2 36
  • 76.29 (n)
  • 85.17 (a)
TUBGCP2 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBGCP2 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubgcp2 36
  • 71.38 (n)
  • 78.96 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
tubgcp2 36
  • 73.37 (n)
  • 78.98 (a)
tubgcp2 37
  • 78 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005575 36
  • 54.38 (n)
  • 39.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7716 37
  • 23 (a)
OneToMany
Grip84 36
  • 53.15 (n)
  • 38.71 (a)
Grip84 37
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPC97 39
SPC98 37
  • 13 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17410 36
  • 47.39 (n)
  • 41.67 (a)
rice
(Oryza sativa)
Liliopsida Os04g0501700 36
  • 46.45 (n)
  • 38.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3710 37
  • 46 (a)
OneToOne
Species with no ortholog for TUBGCP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBGCP2 Gene

ENSEMBL:
Gene Tree for TUBGCP2 (if available)
TreeFam:
Gene Tree for TUBGCP2 (if available)

Paralogs for TUBGCP2 Gene

Paralogs for TUBGCP2 Gene

genes like me logo Genes that share paralogs with TUBGCP2: view

Variants for TUBGCP2 Gene

Sequence variations from dbSNP and Humsavar for TUBGCP2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1317341 -- 133,289,819(-) GGTCC(C/G/T)TGGCG intron-variant
rs1573040 -- 133,293,866(-) ACAAA(G/T)ATGAG intron-variant
rs2275717 -- 133,288,831(+) GGGCA(C/T)GGAAT intron-variant
rs2298120 -- 133,299,436(+) TGCAG(C/T)GTGGA synonymous-codon, reference, nc-transcript-variant
rs2298121 - 133,299,552(+) AGCAG(C/T)GGCTG missense, reference, utr-variant-5-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBGCP2 Gene

Variant ID Type Subtype PubMed ID
nsv896182 CNV Loss 21882294
dgv856n71 CNV Loss 21882294
nsv528260 CNV Loss 19592680
dgv327e1 CNV Complex 17122850
dgv328e1 CNV Complex 17122850
nsv896258 CNV Loss 21882294
nsv832036 CNV Loss 17160897
nsv832038 CNV Gain+Loss 17160897
dgv878n71 CNV Loss 21882294
dgv879n71 CNV Loss 21882294
dgv880n71 CNV Loss 21882294
nsv470980 CNV Loss 18288195
dgv2e196 CNV Duplication 17116639
dgv882n71 CNV Loss 21882294
essv9566 CNV CNV 17122850
dgv883n71 CNV Loss 21882294
dgv885n71 CNV Loss 21882294
dgv886n71 CNV Gain 21882294
dgv887n71 CNV Gain 21882294
essv20368 CNV CNV 17122850
nsv428243 CNV Gain 18775914
nsv509381 CNV Insertion 20534489
dgv122n27 CNV Loss 19166990
nsv896310 CNV Loss 21882294
dgv3e196 CNV Duplication 17116639
nsv896312 CNV Loss 21882294
esv2750853 CNV Gain 17911159
dgv889n71 CNV Loss 21882294
nsv896314 CNV Gain 21882294
esv2536519 CNV Deletion 19546169
esv23338 CNV Gain+Loss 19812545
nsv512195 CNV Loss 21212237
esv2894 CNV Deletion 18987735
esv7552 CNV Loss 19470904
nsv819663 CNV Loss 19587683
nsv832040 CNV Loss 17160897
esv988628 CNV Insertion 20482838

Relevant External Links for TUBGCP2 Gene

HapMap Linkage Disequilibrium report
TUBGCP2

Disorders for TUBGCP2 Gene

No disorders were found for TUBGCP2 Gene.

No data available for UniProtKB/Swiss-Prot for TUBGCP2 Gene

Publications for TUBGCP2 Gene

  1. The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. (PMID: 9566967) Murphy S.M. … Stearns T. (J. Cell Biol. 1998) 2 3 4 23
  2. GCP5 and GCP6: two new members of the human gamma-tubulin complex. (PMID: 11694571) Murphy S.M. … Stearns T. (Mol. Biol. Cell 2001) 3 23
  3. Stability of the small gamma-tubulin complex requires HCA66, a protein of the centrosome and the nucleolus. (PMID: 19299467) Fant X. … Merdes A. (J. Cell. Sci. 2009) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3 4

Products for TUBGCP2 Gene

  • antibodies-online peptides for TUBGCP2
  • antibodies-online antibodies for TUBGCP2
  • antibodies-online kits for TUBGCP2

Sources for TUBGCP2 Gene

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