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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBG2 Gene

protein-coding   GIFtS: 60
GCID: GC17P040811

Tubulin, Gamma 2

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin, Gamma 21 2
gamma-2-tubulin2
Tubulin Gamma-2 Chain2
Gamma-2-tubulin3

External Ids:    HGNC: 124191   Entrez Gene: 271752   Ensembl: ENSG000000370427   OMIM: 6057855   UniProtKB: Q9NRH33   

Export aliases for TUBG2 gene to outside databases

Previous GC identifers: GC17M040390 GC17P042975 GC17P040720 GC17P041184 GC17P041144 GC17P038064 GC17P036576


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TUBG2 Gene: 
TUBG2 (tubulin, gamma 2) is a protein-coding gene. Diseases associated with TUBG2 include juvenile astrocytoma, and lafora disease, and among its related super-pathways are G2/M Transition and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot: TBG2_HUMAN, Q9NRH3
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)

summary for TUBG2 Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBG2 gene promoter:
         CREB   Pax-2b   AML1a   deltaCREB   Pax-2   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBG2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBG2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.31

TUBG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBG2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040811:  view genomic region     (about GC identifiers)

Start:
40,811,266 bp from pter      End:
40,819,024 bp from pter
Size:
7,759 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBG2_HUMAN, Q9NRH3 (See protein sequence)
Recommended Name: Tubulin gamma-2 chain  
Size: 451 amino acids; 51092 Da
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (Probable)
Secondary accessions: A6NDI4 Q32NB2

Explore the universe of human proteins at neXtProt for TUBG2: NX_Q9NRH3

Explore proteomics data for TUBG2 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of
    gamma-tubulin and its associated proteins from the cytoplasm to the centrosome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NRH3

  • TUBG2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUBG2 Protein Expression
    REFSEQ proteins: NP_057521.1  
    ENSEMBL proteins: 
     ENSP00000251412  
    Reactome Protein details: Q9NRH3
    Human Recombinant Protein Products for TUBG2: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material IEA--
    GO:0000930gamma-tubulin complex IEA--
    GO:0005813centrosome ----
    GO:0005829cytosol TAS--
    GO:0005874microtubule IDA--

    TUBG2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TUB: Tubulins

    5/7 InterPro protein domains (see all 7):
     IPR002454 Gamma_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry Q9NRH3

    ProtoNet protein and cluster: Q9NRH3

    1 Blocks protein domain: IPB002454 Gamma tubulin signature

    UniProtKB/Swiss-Prot: TBG2_HUMAN, Q9NRH3
    Similarity: Belongs to the tubulin family


    TUBG2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBG2_HUMAN, Q9NRH3
    Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
    centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
    alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005198structural molecule activity TAS10903841
    GO:0005525GTP binding IEA--
         
    TUBG2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tubg2):
     normal 

    TUBG2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tubg2tm1Sts for TUBG2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUBG2 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUBG2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    G2/M Transition0.83
    Centrosome maturation0.83
    Mitotic G2-G2/M phases0.81
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    5Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TUBG2
        Cytoskeleton remodeling Neurofilaments

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TUBG2 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Epithelial Adherens Junctions
    Parkinson's Disease Pathway

    1 GeneGo (Thomson Reuters) Pathway for TUBG2
        Cytoskeleton remodeling Neurofilaments


    5/7        Reactome Pathways for TUBG2 (see all 7)
        Centrosome maturation
    G2/M Transition
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    Mitotic G2-G2/M phases



    TUBG2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUBG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for TUBG2 (Q9NRH33 ENSP000002514124) via UniProtKB, MINT, STRING, and/or I2D (see all 73)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=1 STRING: ENSP00000291295
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    MAPRE1Q156913, ENSP000003647214I2D: score=1 STRING: ENSP00000364721
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006184GTP catabolic process ----
    GO:0007017microtubule-based process ----
    GO:0007020microtubule nucleation IEA--

    TUBG2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TUBG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    Search CenterWatch for drugs/clinical trials and news about TUBG2 / TBG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUBG2 gene: 
    NM_016437.2  

    Unigene Cluster for TUBG2:

    Tubulin, gamma 2
    Hs.708059  [show with all ESTs]
    Unigene Representative Sequence: BC051890
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251412(uc010wgr.2 uc002iap.3) ENST00000588870 ENST00000590396


    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF225971.1 AK022324.1 AK225134.1 BC009670.2 BC051890.1 BC052283.1 BC108739.1 

    24 DOTS entries:

    DT.114725  DT.95204633  DT.101955381  DT.100658714  DT.100762577  DT.449247  DT.120999047  DT.95290193 
    DT.102838251  DT.92455238  DT.95293078  DT.95353315  DT.97771207  DT.100720891  DT.120999009  DT.120999108 
    DT.92455259  DT.95121830  DT.95175362  DT.120999106  DT.86817570  DT.91764176  DT.95158074  DT.95165534 

    24/691 AceView cDNA sequences (see all 691):

    AI874365 BE794061 BM543567 AW614585 BE207048 AL539078 CD251583 AW304199 
    BM803915 CR592317 BI116398 BM764173 BQ053355 BF341146 CR603755 BQ055782 
    BU181954 CR623455 BE312045 BI821021 AI139593 CR407642 BC009670 CR597415 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TUBG2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                                                  
    SP2:                                                        -           -                                             
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for TUBG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBG2 expression in normal human tissues (normalized intensities)      TUBG2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTAACTTT
    TUBG2 Expression
    About this image


    TUBG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
             orbitofrontal cortex   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See TUBG2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUBG2

    SOURCE GeneReport for Unigene cluster: Hs.708059
        SABiosciences Custom PCR Arrays for TUBG2
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBG2 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubg21 , 5 tubulin, gamma 21, 5 92.02(n)1
    97.56(a)1
      11 (64.30 cM)5
    1037681  NM_134028.21  NP_598789.11 
     1011559075 
    chicken
    (Gallus gallus)
    Aves --
    --
    96(a)
    possible ortholog
    27(4982347-4989442)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Tubulin gamma chain
    93(a)
    1 → many
    6(61805142-61823982)
    zebrafish
    (Danio rerio)
    Actinopterygii tubg16
    tubulin, gamma 1
    96(a)
    1 → many
    3(37054585-37077400)
    fruit fly
    (Drosophila melanogaster)
    Insecta &ggr;Tub23C3
    gammaTub23C1
    microtubule-based process structural
    constituent more3
    gamma-Tubulin at 23C1
    77(a)
    (best of 2)3
    71.2(n)1
    78.62(a)1
      335011  NM_057456.31  NP_476804.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB46
    Gamma-tubulin, involved in nucleating microtubules...
    38(a)
    1 → many
    XII(564860-566281)
    rice
    (Oryza sativa)
    Liliopsida Os.23492 Oryza sativa gamma-tubulin (TubG2) mRNA, complete cds 73.87(n)    AK102557.1 


    ENSEMBL Gene Tree for TUBG2 (if available)
    TreeFam Gene Tree for TUBG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBG2 gene
    TUBG12  TUBD12  
    18/25 SIMAP similar genes for TUBG2 using alignment to 1 protein entry:     TBG2_HUMAN(see all similar genes):
    TUBG1    TUBB2A    TUBB3    XTP3TPATP1    TUBB1    TUBB2B
    TUBB2C    TUBB4B    TUBB8    DKFZp566F223    TUBB4A    TUBB
    TUBB6    DKFZp686L04275    TUBA3E    TUBA8    MGC16703    TUBA1A

    TUBG2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/271 SNPs in TUBG2 are shown (see all 271)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426279911,2
    C--40809368(+) GAGAGC/TGAAAC 1 -- us2k10--------
    rs600696511,2
    C--40809381(+) AAAAAA/-GATTG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1818236221,2
    C--40809539(+) CTACTG/TAAAAT 1 -- us2k10--------
    rs1863615431,2
    --40809557(+) AATTAC/GCCGGG 1 -- us2k10--------
    rs98984391,2
    C,F,H--40809583(+) ctgtaG/Atctca 1 -- us2k17Minor allele frequency- A:0.36NA WA CSA 14
    rs1411229681,2
    C--40809595(+) CTACTA/GGGGAG 1 -- us2k10--------
    rs1434331151,2
    --40809654(+) GAGCCA/GAGATC 1 -- us2k10--------
    rs1467550221,2
    --40809679(+) CAACCC/TGGGCA 1 -- us2k10--------
    rs47930781,2
    C,F,H--40809699(+) gacttT/Agtctc 1 -- us2k17Minor allele frequency- A:0.15NA WA CSA 13
    rs3694647431,2
    C--40809705(+) AGTCT-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TUBG2 (40811266 - 40819024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TUBG2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833450CNV Loss17160897
    nsv908256CNV Loss21882294
    esv33998OTHER Inversion15654335

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605785    OMIM disorders: --

    6 diseases for TUBG2:    About MalaCards
    juvenile astrocytoma    lafora disease    pilocytic astrocytoma    astrocytoma
    parkinson's disease    breast cancer


    TUBG2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TUBG2
    Human Genome Epidemiology (HuGE) Navigator: TUBG2 (1 document)

    Export disorders for TUBG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBG2 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with TUBG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The gamma-tubulin gene family in humans. (PubMed id 10903841)1, 2 Wise D.O.... Oakley B.R. (2000)
    5. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. g-Tubulin 2 nucleates microtubules and is downregulate d in mouse early embryogenesis. (PubMed id 22235350)1 Vinopal S....Draber P. (2012)
    8. Overexpression of g-tubulin in non-small cell lung can cer. (PubMed id 22806905)1 Maounis N.F....Katsetos C.D. (2012)
    9. PEX14 is required for microtubule-based peroxisome mo tility in human cells. (PubMed id 21525035)1 Bharti P....Erdmann R. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27175 HGNC: 12419 AceView: TUBG1andTUBG2 Ensembl:ENSG00000037042 euGenes: HUgn27175
    ECgene: TUBG2 H-InvDB: TUBG2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUBG2 gene:
    Search GeneIP for patents involving TUBG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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