Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TUBG2 Gene

Aliases for TUBG2 Gene

  • Tubulin, Gamma 2 2 3
  • Gamma-2-Tubulin 3 4
  • Tubulin Gamma-2 Chain 3

External Ids for TUBG2 Gene

Summaries for TUBG2 Gene

GeneCards Summary for TUBG2 Gene

TUBG2 (Tubulin, Gamma 2) is a Protein Coding gene. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot for TUBG2 Gene

  • Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Tocris Summary for TUBG2 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBG2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBG2 Gene

Genomics for TUBG2 Gene

Genomic Location for TUBG2 Gene

Start:
42,659,248 bp from pter
End:
42,667,006 bp from pter
Size:
7,759 bases
Orientation:
Plus strand

Genomic View for TUBG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBG2 Gene

Regulatory Elements for TUBG2 Gene

Proteins for TUBG2 Gene

  • Protein details for TUBG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH3-TBG2_HUMAN
    Recommended name:
    Tubulin gamma-2 chain
    Protein Accession:
    Q9NRH3
    Secondary Accessions:
    • A6NDI4
    • Q32NB2

    Protein attributes for TUBG2 Gene

    Size:
    451 amino acids
    Molecular mass:
    51092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBG2 Gene

Proteomics data for TUBG2 Gene at MOPED

Post-translational modifications for TUBG2 Gene

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys287, Lys301, and Lys344

Other Protein References for TUBG2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBG2 Gene

Domains for TUBG2 Gene

Gene Families for TUBG2 Gene

HGNC:
  • TUB :Tubulins

UniProtKB/Swiss-Prot:

TBG2_HUMAN
Family:
  • Belongs to the tubulin family.:
    • Q9NRH3
genes like me logo Genes that share domains with TUBG2: view

Function for TUBG2 Gene

Molecular function for TUBG2 Gene

UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Gene Ontology (GO) - Molecular Function for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 10903841
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBG2: view

Phenotypes for TUBG2 Gene

MGI mutant phenotypes for TUBG2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TUBG2: view

Animal Models for TUBG2 Gene

MGI Knock Outs for TUBG2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TUBG2 Gene

Localization for TUBG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBG2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBG2 Gene COMPARTMENTS Subcellular localization image for TUBG2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000930 gamma-tubulin complex IEA --
GO:0005813 centrosome --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IDA 21525035
genes like me logo Genes that share ontologies with TUBG2: view

Pathways for TUBG2 Gene

genes like me logo Genes that share pathways with TUBG2: view

Gene Ontology (GO) - Biological Process for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0007020 microtubule nucleation IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TUBG2: view

Compounds for TUBG2 Gene

(5) Tocris Compounds for TUBG2 Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Epothilone B Microtubule stabilization agent; promotes tubulin polymerization [152044-54-7]
Vinblastine sulfate Disrupts microtubules [143-67-9]
Vinorelbine ditartrate Selective mitotic microtubule antagonist [125317-39-7]
genes like me logo Genes that share compounds with TUBG2: view

Transcripts for TUBG2 Gene

Unigene Clusters for TUBG2 Gene

Tubulin, gamma 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7: -

Relevant External Links for TUBG2 Gene

GeneLoc Exon Structure for
TUBG2
ECgene alternative splicing isoforms for
TUBG2

Expression for TUBG2 Gene

mRNA expression in normal human tissues for TUBG2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBG2 Gene

SOURCE GeneReport for Unigene cluster for TUBG2 Gene Hs.708059

genes like me logo Genes that share expressions with TUBG2: view

Orthologs for TUBG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBG2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBG2 36
  • 99.63 (n)
  • 100 (a)
TUBG2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBG2 36
  • 93.35 (n)
  • 98.67 (a)
TUBG2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBG1 37
  • 98 (a)
OneToOne
TUBG2 36
  • 93.35 (n)
  • 98.23 (a)
mouse
(Mus musculus)
Mammalia Tubg2 36
  • 92.02 (n)
  • 97.56 (a)
Tubg2 16
Tubg2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TUBG2 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubg2 36
  • 91.5 (n)
  • 97.74 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TUBG2 37
  • 93 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12613 36
zebrafish
(Danio rerio)
Actinopterygii tubg1 37
  • 96 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007834 36
  • 72.57 (n)
  • 78.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta gammaTub23C 36
  • 71.2 (n)
  • 78.62 (a)
gammaTub23C 37
  • 74 (a)
ManyToMany
gammaTub37C 37
  • 76 (a)
ManyToMany
gammaTub23C 38
  • 77 (a)
gammaTub37C 38
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea tbg-1 38
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 37
  • 38 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.90 36
rice
(Oryza sativa)
Liliopsida Os.2349 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 82 (a)
OneToMany
Species with no ortholog for TUBG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TUBG2 Gene

ENSEMBL:
Gene Tree for TUBG2 (if available)
TreeFam:
Gene Tree for TUBG2 (if available)

Paralogs for TUBG2 Gene

Paralogs for TUBG2 Gene

genes like me logo Genes that share paralogs with TUBG2: view

Variants for TUBG2 Gene

Sequence variations from dbSNP and Humsavar for TUBG2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs523150 -- 42,666,264(+) CCCGC(A/G)CCCTG intron-variant
rs523338 -- 42,666,335(+) AGAGC(C/T)TGCAG reference, synonymous-codon
rs524020 -- 42,666,355(+) GAACG(C/G)AAGTT synonymous-codon, reference
rs525911 -- 42,659,901(+) GAGGA(A/G)TTCGC reference, synonymous-codon, utr-variant-5-prime
rs526779 -- 42,659,979(+) GCAGT(G/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBG2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv908256 CNV Loss 21882294
nsv833450 CNV Loss 17160897

Relevant External Links for TUBG2 Gene

HapMap Linkage Disequilibrium report
TUBG2

Disorders for TUBG2 Gene

Relevant External Links for TUBG2

Genetic Association Database (GAD)
TUBG2
Human Genome Epidemiology (HuGE) Navigator
TUBG2
genes like me logo Genes that share disorders with TUBG2: view

No data available for UniProtKB/Swiss-Prot for TUBG2 Gene

Publications for TUBG2 Gene

  1. The gamma-tubulin gene family in humans. (PMID: 10903841) Wise D.O. … Oakley B.R. (Genomics 2000) 3 4
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 49
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes. (PMID: 14767062) Chang F. … Luban J. (Mol. Biol. Cell 2004) 3

Products for TUBG2 Gene

Sources for TUBG2 Gene

Back to Top

Content