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Aliases for TUBG2 Gene

Aliases for TUBG2 Gene

  • Tubulin, Gamma 2 2 3
  • Gamma-2-Tubulin 3 4

External Ids for TUBG2 Gene

Previous GeneCards Identifiers for TUBG2 Gene

  • GC17M040390
  • GC17P042975
  • GC17P040720
  • GC17P041184
  • GC17P041144
  • GC17P038064
  • GC17P040811
  • GC17P036576

Summaries for TUBG2 Gene

GeneCards Summary for TUBG2 Gene

TUBG2 (Tubulin, Gamma 2) is a Protein Coding gene. Among its related pathways are PAK Pathway and ERK Signaling. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot for TUBG2 Gene

  • Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Tocris Summary for TUBG2 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBG2 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBG2 Gene

Genomics for TUBG2 Gene

Regulatory Elements for TUBG2 Gene

Genomic Location for TUBG2 Gene

Chromosome:
17
Start:
42,659,248 bp from pter
End:
42,667,006 bp from pter
Size:
7,759 bases
Orientation:
Plus strand

Genomic View for TUBG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBG2 Gene

Proteins for TUBG2 Gene

  • Protein details for TUBG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRH3-TBG2_HUMAN
    Recommended name:
    Tubulin gamma-2 chain
    Protein Accession:
    Q9NRH3
    Secondary Accessions:
    • A6NDI4
    • Q32NB2

    Protein attributes for TUBG2 Gene

    Size:
    451 amino acids
    Molecular mass:
    51092 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBG2 Gene

Proteomics data for TUBG2 Gene at MOPED

Post-translational modifications for TUBG2 Gene

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBG2 Gene

Domains & Families for TUBG2 Gene

Gene Families for TUBG2 Gene

Suggested Antigen Peptide Sequences for TUBG2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRH3

UniProtKB/Swiss-Prot:

TBG2_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBG2: view

Function for TUBG2 Gene

Molecular function for TUBG2 Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).

Gene Ontology (GO) - Molecular Function for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 10903841
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBG2: view

Phenotypes for TUBG2 Gene

genes like me logo Genes that share phenotypes with TUBG2: view

Animal Models for TUBG2 Gene

MGI Knock Outs for TUBG2:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for TUBG2 Gene

Localization for TUBG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBG2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBG2 Gene COMPARTMENTS Subcellular localization image for TUBG2 gene
Compartment Confidence
cytoskeleton 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000930 gamma-tubulin complex IEA --
GO:0005813 centrosome --
GO:0005829 cytosol TAS --
GO:0005874 microtubule IDA 21525035
genes like me logo Genes that share ontologies with TUBG2: view

Pathways & Interactions for TUBG2 Gene

genes like me logo Genes that share pathways with TUBG2: view

Gene Ontology (GO) - Biological Process for TUBG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0007017 microtubule-based process --
GO:0007020 microtubule nucleation IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TUBG2: view

No data available for SIGNOR curated interactions for TUBG2 Gene

Drugs & Compounds for TUBG2 Gene

(1) Drugs for TUBG2 Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MPC 6827 hydrochloride Pharma Potent microtubule inhibitor, Inhibitor of microtubule polymerization; antimitotic and antitumor 0

(4) Additional Compounds for TUBG2 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ABT 751
141430-65-1
combretastatin a4
117048-59-6
Noscapine hydrochloride
912-60-7
Vinblastine sulfate
143-67-9
genes like me logo Genes that share compounds with TUBG2: view

Transcripts for TUBG2 Gene

Unigene Clusters for TUBG2 Gene

Tubulin, gamma 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBG2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBG2 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4:
SP5: -
SP6:
SP7: -

Relevant External Links for TUBG2 Gene

GeneLoc Exon Structure for
TUBG2
ECgene alternative splicing isoforms for
TUBG2

Expression for TUBG2 Gene

mRNA expression in normal human tissues for TUBG2 Gene

Protein differential expression in normal tissues from HIPED for TUBG2 Gene

This gene is overexpressed in Heart (56.1) and Ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBG2 Gene



SOURCE GeneReport for Unigene cluster for TUBG2 Gene Hs.708059

genes like me logo Genes that share expression patterns with TUBG2: view

Protein tissue co-expression partners for TUBG2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TUBG2 Gene

Orthologs for TUBG2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBG2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TUBG2 35
  • 93.35 (n)
  • 98.67 (a)
TUBG2 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBG2 35
  • 93.35 (n)
  • 98.23 (a)
TUBG1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubg2 35
  • 92.02 (n)
  • 97.56 (a)
Tubg2 16
Tubg2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBG2 35
  • 99.63 (n)
  • 100 (a)
TUBG2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubg2 35
  • 91.5 (n)
  • 97.74 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TUBG2 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 96 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TUBG2 36
  • 93 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12613 35
zebrafish
(Danio rerio)
Actinopterygii tubg1 36
  • 96 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gammaTub23C 37
  • 77 (a)
gammaTub37C 37
  • 77 (a)
gammaTub23C 35
  • 71.2 (n)
  • 78.62 (a)
gammaTub23C 36
  • 74 (a)
ManyToMany
gammaTub37C 36
  • 76 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007834 35
  • 72.57 (n)
  • 78.7 (a)
worm
(Caenorhabditis elegans)
Secernentea tbg-1 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 36
  • 38 (a)
OneToMany
barley
(Hordeum vulgare)
Liliopsida Hv.90 35
rice
(Oryza sativa)
Liliopsida Os.2349 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 82 (a)
OneToMany
Species with no ortholog for TUBG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TUBG2 Gene

ENSEMBL:
Gene Tree for TUBG2 (if available)
TreeFam:
Gene Tree for TUBG2 (if available)

Paralogs for TUBG2 Gene

Paralogs for TUBG2 Gene

genes like me logo Genes that share paralogs with TUBG2: view

Variants for TUBG2 Gene

Sequence variations from dbSNP and Humsavar for TUBG2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs523150 -- 42,666,264(+) CCCGC(A/G)CCCTG intron-variant
rs523338 -- 42,666,335(+) AGAGC(C/T)TGCAG reference, synonymous-codon
rs524020 -- 42,666,355(+) GAACG(C/G)AAGTT synonymous-codon, reference
rs525911 -- 42,659,901(+) GAGGA(A/G)TTCGC reference, synonymous-codon, utr-variant-5-prime
rs526779 -- 42,659,979(+) GCAGT(G/T)GCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBG2 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER Inversion 15654335
nsv908256 CNV Loss 21882294
nsv833450 CNV Loss 17160897

Variation tolerance for TUBG2 Gene

Residual Variation Intolerance Score: 14.65% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.58; 95.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBG2 Gene

HapMap Linkage Disequilibrium report
TUBG2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBG2 Gene

Disorders for TUBG2 Gene

Relevant External Links for TUBG2

Genetic Association Database (GAD)
TUBG2
Human Genome Epidemiology (HuGE) Navigator
TUBG2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBG2
genes like me logo Genes that share disorders with TUBG2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBG2 Gene

Publications for TUBG2 Gene

  1. gamma-Tubulin in Arabidopsis: gene sequence, immunoblot, and immunofluorescence studies. (PMID: 8148650) Liu B. … Snustad D.P. (Plant Cell 1994) 23 67
  2. Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. (PMID: 23826228) He M. … Zhou J. (PLoS ONE 2013) 67
  3. I^-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. (PMID: 22235350) Vinopal S. … DrA!ber P. (PLoS ONE 2012) 67
  4. Overexpression of I^-tubulin in non-small cell lung cancer. (PMID: 22806905) Maounis N.F. … Katsetos C.D. (Histol. Histopathol. 2012) 67
  5. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 67

Products for TUBG2 Gene

Sources for TUBG2 Gene

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