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TUBG2 Gene

protein-coding   GIFtS: 57
GCID: GC17P040811

Tubulin, Gamma 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Gamma 21 2
gamma-2-tubulin2
Tubulin Gamma-2 Chain2
Gamma-2-tubulin3

External Ids:    HGNC: 124191   Entrez Gene: 271752   Ensembl: ENSG000000370427   OMIM: 6057855   UniProtKB: Q9NRH33   

Export aliases for TUBG2 gene to outside databases

Previous GC identifers: GC17M040390 GC17P042975 GC17P040720 GC17P041184 GC17P041144 GC17P038064 GC17P036576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TUBG2 Gene:
TUBG2 (tubulin, gamma 2) is a protein-coding gene. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot: TBG2_HUMAN, Q9NRH3
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)

summary for TUBG2 Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBG2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TUBG2 gene promoter:
         CREB   Pax-2b   AML1a   deltaCREB   Pax-2   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBG2 promoter sequence
   Search Chromatin IP Primers for TUBG2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBG2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.31

TUBG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBG2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040811:  view genomic region     (about GC identifiers)

Start:
40,811,266 bp from pter      End:
40,819,024 bp from pter
Size:
7,759 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBG2_HUMAN, Q9NRH3 (See protein sequence)
Recommended Name: Tubulin gamma-2 chain  
Size: 451 amino acids; 51092 Da
Secondary accessions: A6NDI4 Q32NB2

Explore the universe of human proteins at neXtProt for TUBG2: NX_Q9NRH3

Explore proteomics data for TUBG2 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of
    gamma-tubulin and its associated proteins from the cytoplasm to the centrosome1
  • Ubiquitination2 at Lys287, Lys301, Lys344
  • Modification sites at PhosphoSitePlus

  • See TUBG2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057521.1  
    ENSEMBL proteins: 
     ENSP00000251412  
    Reactome Protein details: Q9NRH3

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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for TUBG2 (6 products) 

     
    antibodies-online peptides for TUBG2

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    antibodies-online kits for TUBG2 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 7):
     IPR002454 Gamma_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry Q9NRH3

    ProtoNet protein and cluster: Q9NRH3

    1 Blocks protein domain: IPB002454 Gamma tubulin signature

    UniProtKB/Swiss-Prot: TBG2_HUMAN, Q9NRH3
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBG2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBG2_HUMAN, Q9NRH3
    Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
    centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
    alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005198structural molecule activity TAS10903841
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with TUBG2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tubg2):
     normal 

    Find genes that share phenotypes with TUBG2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tubg2tm1Sts for TUBG2

       genOway: Develop your customized and physiologically relevant rodent model for TUBG2

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    GenScript: all cDNA clones in your preferred vector: TUBG2 (NM_016437)
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBG2_HUMAN, Q9NRH3: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material IEA--
    GO:0000930gamma-tubulin complex IEA--
    GO:0005813centrosome ----
    GO:0005829cytosol TAS--
    GO:0005874microtubule IDA--

    Find genes that share ontologies with TUBG2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBG2 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Mitotic G2-G2/M phases0.69
    Centrosome maturation0.86
    Recruitment of NuMA to mitotic centrosomes0.00
    G2/M Transition0.70
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with TUBG2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBG2 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Epithelial Adherens Junctions
    Parkinson's Disease Pathway

    1 GeneGo (Thomson Reuters) Pathway for TUBG2
        Cytoskeleton remodeling Neurofilaments


    2 Reactome Pathways for TUBG2
        Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBG2
    Interactions:

        GeneGlobe Interaction Network for TUBG2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBG2 (Q9NRH33 ENSP000002514124) via UniProtKB, MINT, STRING, and/or I2D (see all 177)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=1 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=1 STRING: ENSP00000272298
    CALM3P621583, ENSP000002912954I2D: score=1 STRING: ENSP00000291295
    VBP1P617583, ENSP000002864284I2D: score=4 STRING: ENSP00000286428
    CIAO1O760713, ENSP000004182874I2D: score=1 STRING: ENSP00000418287
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006184GTP catabolic process ----
    GO:0007020microtubule nucleation IEA--
    GO:0031122cytoplasmic microtubule organization IEA--

    Find genes that share ontologies with TUBG2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Compounds for TUBG2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUBG2 gene: 
    NM_016437.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251412(uc010wgr.2 uc002iap.3) ENST00000588870 ENST00000590396

    miRNA
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    hsa-miR-3652
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TUBG2
      QuantiFast Probe-based Assays in human, mouse, rat TUBG2

    Selected AceView cDNA sequences (see all 691):

    BX438743 AW614585 BM764173 BQ009249 BU688933 AW498588 BX361240 AA306395 
    BM543567 BF341146 BU736828 BX324790 BM927828 BE295886 CR607198 BM803915 
    CR590773 CR407642 BE796940 CR599618 BE265685 BU181954 BQ721645 CR602914 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBG2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                                                  
    SP2:                                                        -           -                                             
    SP3:                                                                                                                  
    SP4:                                                                                                                  
    SP5:                                -                                                                                 


    ECgene alternative splicing isoforms for TUBG2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBG2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTAACTTT
    TUBG2 Expression
    About this image


    TUBG2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TUBG2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBG2 Protein Expression
        Custom PCR Arrays for TUBG2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBG2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBG2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubg21 , 5 tubulin, gamma 21, 5 92.02(n)1
    97.56(a)1
      11 (64.30 cM)5
    1037681  NM_134028.21  NP_598789.11 
     1011559075 
    chicken
    (Gallus gallus)
    Aves --
    --
    96(a)
    1 → many
    27(4982347-4989442)
    lizard
    (Anolis carolinensis)
    Reptilia TUBG26
    tubulin, gamma 2
    93(a)
    1 ↔ 1
    6(61805142-61823982)
    zebrafish
    (Danio rerio)
    Actinopterygii tubg16
    tubulin, gamma 1
    96(a)
    1 → many
    3(37054585-37077400) ENSDARG00000015610
    fruit fly
    (Drosophila melanogaster)
    Insecta gammaTub37C3
    gammaTub23C1
    microtubule-based process structural
    constituent more3
    gamma-Tubulin at 23C1
    77(a)
    (best of 2)3
    71.2(n)1
    78.62(a)1
      37C73
    335011  NM_057456.31  NP_476804.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB46
    Gamma-tubulin, involved in nucleating microtubules...
    38(a)
    1 → many
    XII(564860-566281) YLR212C
    rice
    (Oryza sativa)
    Liliopsida Os.23492 Oryza sativa gamma-tubulin (TubG2) mRNA, complete cds 73.87(n)    AK102557.1 


    ENSEMBL Gene Tree for TUBG2 (if available)
    TreeFam Gene Tree for TUBG2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBG2 gene
    TUBG12  TUBD12  
    Selected SIMAP similar genes for TUBG2 using alignment to 1 protein entry:     TBG2_HUMAN(see all similar genes):
    TUBG1    TUBB2A    TUBB3    XTP3TPATP1    TUBB1    TUBB2B
    TUBB2C    TUBB4B    TUBB8    DKFZp566F223    TUBB4A    TUBB
    TUBB6    DKFZp686L04275    TUBA3E    TUBA8    MGC16703    TUBA1A

    Find genes that share paralogs with TUBG2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBG2 (see all 271)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426279911,2
    C--40809368(+) GAGAGC/TGAAAC 1 -- us2k10--------
    rs600696511,2
    C--40809381(+) AAAAAA/-GATTG 1 -- us2k11Minor allele frequency- -:0.00NA 2
    rs1818236221,2
    C--40809539(+) CTACTG/TAAAAT 1 -- us2k10--------
    rs1863615431,2
    --40809557(+) AATTAC/GCCGGG 1 -- us2k10--------
    rs98984391,2
    C,F,H--40809583(+) ctgtaG/Atctca 1 -- us2k17Minor allele frequency- A:0.36NA WA CSA 14
    rs1411229681,2
    C--40809595(+) CTACTA/GGGGAG 1 -- us2k10--------
    rs1434331151,2
    --40809654(+) GAGCCA/GAGATC 1 -- us2k10--------
    rs1467550221,2
    --40809679(+) CAACCC/TGGGCA 1 -- us2k10--------
    rs47930781,2
    C,F,H--40809699(+) gacttT/Agtctc 1 -- us2k17Minor allele frequency- A:0.15NA WA CSA 13
    rs3694647431,2
    C--40809705(+) AGTCT-/AAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TUBG2 (40811266 - 40819024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TUBG2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833450CNV Loss17160897
    nsv908256CNV Loss21882294
    esv33998OTHER Inversion15654335

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605785    OMIM disorders: --


    Find genes that share disorders with TUBG2           About GenesLikeMe

    Genetic Association Database (GAD): TUBG2
    Human Genome Epidemiology (HuGE) Navigator: TUBG2 (1 document)

    Export disorders for TUBG2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBG2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TUBG2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The gamma-tubulin gene family in humans. (PubMed id 10903841)1, 2 Wise D.O.... Oakley B.R. (Genomics 2000)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. I^-Tubulin 2 nucleates microtubules and is downregulated in mouse early embryogenesis. (PubMed id 22235350)1 Vinopal S....DrA!ber P. (PLoS ONE 2012)
    9. Overexpression of I^-tubulin in non-small cell lung cancer. (PubMed id 22806905)1 Maounis N.F....Katsetos C.D. (Histol. Histopathol. 2012)
    10. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27175 HGNC: 12419 AceView: TUBG1andTUBG2 Ensembl:ENSG00000037042 euGenes: HUgn27175
    ECgene: TUBG2 H-InvDB: TUBG2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TUBG2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TUBG2 gene:
    Search GeneIP for patents involving TUBG2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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