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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBG1 Gene

protein-coding   GIFtS: 67
GCID: GC17P040761

Tubulin, Gamma 1

(Previous names: tubulin, gamma polypeptide)
(Previous symbol: TUBG)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin, Gamma 11 2     CDCBM42
TUBG1 2 3     TUBGCP12
Tubulin, Gamma Polypeptide1 2     gamma-1-tubulin2
Gamma-Tubulin Complex Component 12 3     Tubulin Gamma-1 Chain2
GCP-12 3     Gamma-1-tubulin3

External Ids:    HGNC: 124171   Entrez Gene: 72832   Ensembl: ENSG000001314627   OMIM: 1911355   UniProtKB: P232583   

Export aliases for TUBG1 gene to outside databases

Previous GC identifers: GC17P040369 GC17P042949 GC17P040670 GC17P041134 GC17P038015 GC17P036525


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUBG1 Gene:
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it
binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates
microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene
of this gene is found on chromosome 7. (provided by RefSeq, Jan 2009)

GeneCards Summary for TUBG1 Gene: 
TUBG1 (tubulin, gamma 1) is a protein-coding gene. Diseases associated with TUBG1 include myofibrillar myopathy, and anaplastic astrocytoma, and among its related super-pathways are G2/M Transition and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.

UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation

summary for TUBG1 Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBG1 gene promoter:
         NF-1   NF-1/L   AML1a   Tal-1beta   GATA-1   COMP1   Zic1   ZIC2/Zic2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.31

TUBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBG1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040761:  view genomic region     (about GC identifiers)

Start:
40,761,358 bp from pter      End:
40,767,256 bp from pter
Size:
5,899 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258 (See protein sequence)
Recommended Name: Tubulin gamma-1 chain  
Size: 451 amino acids; 51170 Da
Subunit: Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the
interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO
Subcellular location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Mass spectrometry: Mass=51197.98; Method=MALDI; Range=1-451; Source=PubMed:11840567;
3 PDB 3D structures from and Proteopedia for TUBG1:
1Z5V (3D)        1Z5W (3D)        3CB2 (3D)    
Secondary accessions: Q53X79 Q9BW59

Explore the universe of human proteins at neXtProt for TUBG1: NX_P23258

Explore proteomics data for TUBG1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of
    gamma-tubulin and its associated proteins from the cytoplasm to the centrosome (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P23258

  • TUBG1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUBG1 Protein Expression
    REFSEQ proteins: NP_001061.2  
    ENSEMBL proteins: 
     ENSP00000251413   ENSP00000464867   ENSP00000465582  
    Reactome Protein details: P23258
    Human Recombinant Protein Products for TUBG1: 
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    Gene Ontology (GO): 5/15 cellular component terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material IEA--
    GO:0000794condensed nuclear chromosome ISS--
    GO:0000930gamma-tubulin complex TAS9566969
    GO:0005737cytoplasm ISS--
    GO:0005813centrosome IDA17286961

    TUBG1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TUB: Tubulins

    5/7 InterPro protein domains (see all 7):
     IPR002454 Gamma_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry P23258

    ProtoNet protein and cluster: P23258

    1 Blocks protein domain: IPB002454 Gamma tubulin signature

    UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
    Similarity: Belongs to the tubulin family


    TUBG1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBG1_HUMAN, P23258
    Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
    centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
    alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation

         Genatlas biochemistry entry for TUBG1:
    tubulin,gamma polypeptide,universal component of microtubule organizing center,associated with centrosome (nb

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton TAS1904010
    GO:0005515protein binding IPI14594945
    GO:0005525GTP binding IEA--
         
    TUBG1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TUBG1:
     Decreased Wnt reporter activit  Decreased viability with pacli  Metaphase cells 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tubg1):
     cellular  embryogenesis  mortality/aging 

    TUBG1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tubg1tm1Sts for TUBG1

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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TUBG1 (see all 10):
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    SwitchGear 3'UTR luciferase reporter plasmidTUBG1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUBG1 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    5Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Keratin filaments0.91

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TUBG1
        Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Keratin filaments

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TUBG1 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Epithelial Adherens Junctions
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for TUBG1
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for TUBG1
        Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Neurofilaments

    1 BioSystems Pathway for TUBG1
        PLK1 signaling events


    5/9        Reactome Pathways for TUBG1 (see all 9)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes
    G2/M Transition



    TUBG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUBG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/877 Interacting proteins for TUBG1 (P232581, 2, 3 ENSP000002514134) via UniProtKB, MINT, STRING, and/or I2D (see all 877)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151692, 3, ENSP000002623204MINT-7229816 MINT-7229788 MINT-7229797 MINT-7229778 I2D: score=1 STRING: ENSP00000262320
    PLK1P533502, 3, ENSP000003000934MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000300093
    TUBB4BP683712, 3, ENSP000003412894MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000341289
    GSK3BP498412, 3, ENSP000003248064MINT-4051287 MINT-4051230 I2D: score=1 STRING: ENSP00000324806
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-7945693 MINT-6173837 I2D: score=1 STRING: ENSP00000307387
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000212meiotic spindle organization ISS--
    GO:0000226microtubule cytoskeleton organization TAS1904010
    GO:0000278mitotic cell cycle TAS--
    GO:0006184GTP catabolic process ----

    TUBG1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TUBG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for TUBG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 DrugBank Compound for TUBG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vinblastine-- 865-21-4targetadduct14619954 9664292 1818332 15579115 18220533

    10/15 Novoseek inferred chemical compound relationships for TUBG1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 79.8 21 11093584 (3), 8824733 (2), 8089179 (1), 17705289 (1) (see all 14)
    colcemid 53.8 2 19226218 (1)
    gtp 38.5 12 15917813 (2), 18388201 (2), 8104191 (1), 7820871 (1) (see all 5)
    sucrose 35.6 15 7622595 (1), 9186012 (1), 11003675 (1), 12696185 (1) (see all 10)
    paclitaxel 33.2 7 11093584 (3), 8640766 (1), 18485433 (1), 9258503 (1) (see all 5)
    colchicine 31.8 3 7553905 (2), 9523151 (1)
    dimethylarsinic acid 25.9 5 11035156 (2), 11804606 (2)
    gdp 17 3 10037793 (1), 18388201 (1)
    mgatp 10.2 1 7622595 (1)
    tyrosine 3.16 9 15242776 (4), 18636972 (2), 19564412 (1), 19748892 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TUBG1 / TBG1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for TUBG1 gene: 
    NM_001070.4  

    Unigene Cluster for TUBG1:

    Tubulin, gamma 1
    Hs.279669  [show with all ESTs]
    Unigene Representative Sequence: NM_001070
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251413(uc002ian.3) ENST00000588056 ENST00000591509 ENST00000589688
    ENST00000589613

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    Additional mRNA sequence: 

    AK310562.1 AK311637.1 AK313339.1 BC000619.2 BT019931.1 CR407642.1 M61764.1 

    24/28 DOTS entries (see all 28):

    DT.100762577  DT.449247  DT.102838254  DT.92455259  DT.102838251  DT.114725  DT.120999000  DT.95165537 
    DT.95165540  DT.95204633  DT.100850368  DT.100872582  DT.120999043  DT.120999102  DT.120999106  DT.40288992 
    DT.91661394  DT.92455251  DT.95183389  DT.100658714  DT.120999002  DT.120999047  DT.86850962  DT.92455238 

    24/691 AceView cDNA sequences (see all 691):

    BE258251 BM763367 BQ652293 CR605839 AL539078 BU181954 AI128080 BM847555 
    CR602961 BP365101 CR615504 BX283965 BQ233455 BM976811 CR590773 BQ068287 
    BX324790 AI870955 BU194909 CR597415 BM799291 BM846639 BU859805 NM_001070 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TUBG1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                                -                                                                                       
    SP2:                                -                                                                                       
    SP3:                                                                                                                        
    SP4:                                                                                -     -                                 
    SP5:                                            -     -     -                                                               


    ECgene alternative splicing isoforms for TUBG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBG1 expression in normal human tissues (normalized intensities)      TUBG1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCTCTGT
    TUBG1 Expression
    About this image


    TUBG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus (Reproductive System)    fully expand to see all 5 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See TUBG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUBG1

    SOURCE GeneReport for Unigene cluster: Hs.279669
        SABiosciences Custom PCR Arrays for TUBG1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBG1 gene from 9/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubg11 , 5 tubulin, gamma 11, 5 92.76(n)1
    98.89(a)1
      11 (64.24 cM)5
    1037331  NM_134024.21  NP_598785.11 
     1011199385 
    chicken
    (Gallus gallus)
    Aves TUBG11 tubulin, gamma 1 85.21(n)
    98.59(a)
      420025  XM_418146.3  XP_418146.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Tubulin gamma chain
    94(a)
    1 → many
    6(61805142-61823982)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58712 X.laevis gamma-tubulin mRNA, complete cds 80.13(n)    M63446.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558942 similar to tubulin, gamma 1 83.48(n)   393882  BC045486.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta &ggr;Tub23C3
    gammaTub37C1
    microtubule-based process structural
    constituent more3
    gamma-Tubulin at 37C1
    77(a)
    (best of 2)3
    71.45(n)1
    78.25(a)1
      351991  NM_057574.41  NP_476922.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB4(YLR212C)4 Gamma-tubulin, involved in nucleating microtubules more   --   12(566281-564860) 850909  NP_013313.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCP21 tubulin gamma-2 chain 65.41(n)
    75.56(a)
      830445  NM_120644.2  NP_196181.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01566001 hypothetical protein 67.04(n)
    75.56(a)
      4337861  NM_001061233.1  NP_001054698.1 


    ENSEMBL Gene Tree for TUBG1 (if available)
    TreeFam Gene Tree for TUBG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBG1 gene
    TUBG22  TUBD12  
    18/28 SIMAP similar genes for TUBG1 using alignment to 3 protein entries:     TBG1_HUMAN (see all proteins) (see all similar genes):
    TUBG2    TUBB2A    TUBB6    TUBB4A    TUBB2B    TUBB1
    TUBB2C    TUBB4B    TUBB8    TUBB3    DKFZp566F223    TUBB
    TUBB4Q    MGC16703    TUBA1B    TUBA1A    DKFZp686L04275    TUBA1C

    TUBG1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TUBG1
    PGOHUM00000233209


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/130 SNPs in TUBG1 are shown (see all 130)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1923216581,2
    --40763517(+) CCTTCA/GTTGTA 1 -- int10--------
    rs784591011,2
    F--40763531(+) ATGAGG/AAAACT 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1448367341,2
    --40763622(+) TAATCC/GTAGCA 1 -- int10--------
    rs1387579601,2
    --40763747(+) CATGCA/GCCTAT 1 -- int10--------
    rs1843888421,2
    --40763768(+) ACTGGA/GGAGGC 1 -- int10--------
    rs1893218371,2
    --40763958(+) TCTCAA/GTGTAG 1 -- int10--------
    rs1999482281,2
    C--40764192(+) GAGCCA/GACATG 1 -- int10--------
    rs1128093041,2
    C--40764195(+) CCGACG/ATGGGC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs1813550721,2
    --40764226(+) AGAAGA/CGACCT 1 -- int10--------
    rs1849992461,2
    --40764342(+) GGGAAC/GCAAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TUBG1 (40761358 - 40767256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TUBG1:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3172n71CNV Loss21882294
    esv33998OTHER Inversion15654335

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191135    OMIM disorders: --

    20/22 diseases for TUBG1 (see all 22):    About MalaCards
    myofibrillar myopathy    anaplastic astrocytoma    nijmegen breakage syndrome    inclusion body myositis
    astrocytoma    myositis    retinitis pigmentosa    myopathy
    glioblastoma    medulloblastoma    malaria    parkinson's disease
    retinitis    pancreatic cancer    neuroblastoma    sarcoma
    breast cancer    ovarian cancer    squamous cell carcinoma    pancreatitis


    TUBG1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/15 Novoseek inferred disease relationships for TUBG1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma ductal 25 1 16606540 (1)
    glioblastoma 15.1 14 17406983 (4), 16772870 (3), 20162618 (2)
    breast cancer 12.3 5 20009567 (3), 14506732 (1)
    anaplastic astrocytoma 9.49 1 17406983 (1)
    carcinoma 6.74 6 16606540 (2), 19131428 (1), 19215229 (1), 12866024 (1) (see all 5)
    tumors 5.09 17 20009567 (2), 20162618 (2), 12750257 (2), 19328337 (1) (see all 8)
    breast carcinoma 2.62 1 16606540 (1)
    astrocytoma 0 5 17406983 (3), 16772870 (2)
    shock 0 6 8464918 (2), 8886893 (1), 7782067 (1), 19748892 (1)
    primary tumor 0 2 16772870 (1)

    Genetic Association Database (GAD): TUBG1
    Human Genome Epidemiology (HuGE) Navigator: TUBG1 (2 documents)

    Export disorders for TUBG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBG1 gene, integrated from 9 sources (see all 306):
    (articles sorted by number of sources associating them with TUBG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. (PubMed id 1904010)1, 2, 3, 9 Zheng Y.... Oakley B.R. (1991)
    2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PubMed id 9566969)1, 2, 9 Tassin A.-M.... Bornens M. (1998)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)
    6. The gamma-tubulin gene family in humans. (PubMed id 10903841)1, 9 Wise D.O.... Oakley B.R. (2000)
    7. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. (PubMed id 7592789)1, 9 Kapeller R....Carpenter C.L. (1995)
    8. A Direct interaction with NEDD1 regulates gamma-tubul in recruitment to the centrosome. (PubMed id 20224777)1, 9 Manning J.A....Kumar S. (2010)
    9. Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. (PubMed id 17406983)1, 9 Katsetos C.D....Draber P. (2007)
    10. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. (PubMed id 15917813)1, 9 Aldaz H....Agard D.A. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7283 HGNC: 12417 AceView: TUBG1andTUBG2 Ensembl:ENSG00000131462 euGenes: HUgn7283
    ECgene: TUBG1 H-InvDB: TUBG1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUBG1 gene:
    Search GeneIP for patents involving TUBG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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