Aliases for TUBG1 Gene
External Ids for TUBG1 Gene
Previous HGNC Symbols for TUBG1 Gene
Previous GeneCards Identifiers for TUBG1 Gene
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]
GeneCards Summary for TUBG1 Gene
TUBG1 (Tubulin Gamma 1) is a Protein Coding gene. Diseases associated with TUBG1 include cortical dysplasia, complex, with other brain malformations 4 and microcephaly 12, primary, autosomal recessive. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.
UniProtKB/Swiss-Prot for TUBG1 Gene
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).