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Aliases for TUBG1 Gene

Aliases for TUBG1 Gene

  • Tubulin Gamma 1 2 3 5
  • Gamma-Tubulin Complex Component 1 3 4
  • Tubulin, Gamma Polypeptide 2 3
  • Tubulin, Gamma 1 2 3
  • GCP-1 3 4
  • TUBG 3 4
  • Gamma-1-Tubulin 4
  • TUBGCP1 3
  • CDCBM4 3

External Ids for TUBG1 Gene

Previous HGNC Symbols for TUBG1 Gene

  • TUBG

Previous GeneCards Identifiers for TUBG1 Gene

  • GC17P040369
  • GC17P042949
  • GC17P040670
  • GC17P041134
  • GC17P038015
  • GC17P040761
  • GC17P036525

Summaries for TUBG1 Gene

Entrez Gene Summary for TUBG1 Gene

  • This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]

GeneCards Summary for TUBG1 Gene

TUBG1 (Tubulin Gamma 1) is a Protein Coding gene. Diseases associated with TUBG1 include cortical dysplasia, complex, with other brain malformations 4 and subcortical band heterotopia. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Cell Cycle, Mitotic. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.

UniProtKB/Swiss-Prot for TUBG1 Gene

  • Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

Tocris Summary for TUBG1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBG1 Gene

Genomics for TUBG1 Gene

Regulatory Elements for TUBG1 Gene

Promoters for TUBG1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TUBG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBG1 Gene

Chromosome:
17
Start:
42,609,340 bp from pter
End:
42,615,238 bp from pter
Size:
5,899 bases
Orientation:
Plus strand

Genomic View for TUBG1 Gene

Genes around TUBG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBG1 Gene

Proteins for TUBG1 Gene

  • Protein details for TUBG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23258-TBG1_HUMAN
    Recommended name:
    Tubulin gamma-1 chain
    Protein Accession:
    P23258
    Secondary Accessions:
    • Q53X79
    • Q9BW59

    Protein attributes for TUBG1 Gene

    Size:
    451 amino acids
    Molecular mass:
    51170 Da
    Quaternary structure:
    • Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO.

    Three dimensional structures from OCA and Proteopedia for TUBG1 Gene

neXtProt entry for TUBG1 Gene

Proteomics data for TUBG1 Gene at MOPED

Post-translational modifications for TUBG1 Gene

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TUBG1 (TUBG1)

No data available for DME Specific Peptides for TUBG1 Gene

Domains & Families for TUBG1 Gene

Gene Families for TUBG1 Gene

Suggested Antigen Peptide Sequences for TUBG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23258

UniProtKB/Swiss-Prot:

TBG1_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBG1: view

Function for TUBG1 Gene

Molecular function for TUBG1 Gene

GENATLAS Biochemistry:
tubulin,gamma polypeptide,universal component of microtubule organizing center,associated with centrosome (nb
UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.
genes like me logo Genes that share phenotypes with TUBG1: view

Human Phenotype Ontology for TUBG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TUBG1 Gene

MGI Knock Outs for TUBG1:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TUBG1 Gene

Localization for TUBG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBG1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBG1 Gene COMPARTMENTS Subcellular localization image for TUBG1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
nucleus 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000930 gamma-tubulin complex IEA,TAS 9566969
GO:0005814 centriole IEA --
GO:0005827 polar microtubule IDA 9566969
GO:0005876 spindle microtubule IEA --
genes like me logo Genes that share ontologies with TUBG1: view

Pathways & Interactions for TUBG1 Gene

genes like me logo Genes that share pathways with TUBG1: view

SIGNOR curated interactions for TUBG1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization TAS 1904010
GO:0000278 mitotic cell cycle TAS --
GO:0007017 microtubule-based process IEA --
GO:0007020 microtubule nucleation IEA --
GO:0031122 cytoplasmic microtubule organization IEA --
genes like me logo Genes that share ontologies with TUBG1: view

Drugs & Compounds for TUBG1 Gene

(10) Drugs for TUBG1 Gene - From: Novoseek, Tocris, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 104
Vinblastine Approved Pharma Target, adduct 230
Taxol Approved August 1997 Pharma Agonist Promotes assembly and inhibits disassembly of microtubules 0
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0

(9) Additional Compounds for TUBG1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Vinblastine sulfate
143-67-9
Vincristine sulfate
2068-78-2

(5) Tocris Compounds for TUBG1 Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Nocodazole Microtubule inhibitor 31430-18-9
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
Vincristine sulfate Disrupts microtubules 2068-78-2
genes like me logo Genes that share compounds with TUBG1: view

Transcripts for TUBG1 Gene

Unigene Clusters for TUBG1 Gene

Tubulin, gamma 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: -
SP3:
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for TUBG1 Gene

GeneLoc Exon Structure for
TUBG1
ECgene alternative splicing isoforms for
TUBG1

Expression for TUBG1 Gene

mRNA expression in normal human tissues for TUBG1 Gene

mRNA differential expression in normal tissues according to GTEx for TUBG1 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for TUBG1 Gene

This gene is overexpressed in Breast (34.7) and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBG1 Gene



SOURCE GeneReport for Unigene cluster for TUBG1 Gene Hs.279669

genes like me logo Genes that share expression patterns with TUBG1: view

Protein tissue co-expression partners for TUBG1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TUBG1 Gene

Orthologs for TUBG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBG1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TUBG1 35
  • 94.01 (n)
  • 99.33 (a)
TUBG1 36
  • 99 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TUBG1 35
  • 93.87 (n)
  • 98 (a)
mouse
(Mus musculus)
Mammalia Tubg1 35
  • 92.76 (n)
  • 98.89 (a)
Tubg1 16
Tubg1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBG1 35
  • 99.48 (n)
  • 100 (a)
TUBG1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubg1 35
  • 92.68 (n)
  • 98.89 (a)
oppossum
(Monodelphis domestica)
Mammalia TUBG1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TUBG1 35
  • 85.21 (n)
  • 98.59 (a)
-- 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tubg1 35
  • 80.71 (n)
  • 98.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5871 35
zebrafish
(Danio rerio)
Actinopterygii tubg1 35
  • 83.3 (n)
  • 98 (a)
zgc55894 35
tubg1 36
  • 98 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gammaTub23C 37
  • 77 (a)
gammaTub37C 37
  • 77 (a)
gammaTub37C 35
  • 71.45 (n)
  • 78.25 (a)
gammaTub23C 36
  • 75 (a)
ManyToMany
gammaTub37C 36
  • 76 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tbg-1 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 36
  • 37 (a)
OneToMany
TUB4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GCP2 35
  • 65.41 (n)
  • 75.56 (a)
rice
(Oryza sativa)
Liliopsida Os05g0156600 35
  • 67.04 (n)
  • 75.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9986 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03954 35
  • 66.97 (n)
  • 68.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtb1 35
  • 61.85 (n)
  • 71.56 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 83 (a)
OneToMany
Species with no ortholog for TUBG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBG1 Gene

ENSEMBL:
Gene Tree for TUBG1 (if available)
TreeFam:
Gene Tree for TUBG1 (if available)

Paralogs for TUBG1 Gene

Paralogs for TUBG1 Gene

Pseudogenes.org Pseudogenes for TUBG1 Gene

genes like me logo Genes that share paralogs with TUBG1: view

Variants for TUBG1 Gene

Sequence variations from dbSNP and Humsavar for TUBG1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs13663 - 42,614,922(+) AGGAC(A/G)TGTTC reference, missense
VAR_070577 Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)
VAR_070578 Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)
VAR_070579 Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)
rs572 -- 42,613,866(+) ATGTC(A/G/T)GCCAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TUBG1 Gene

Variant ID Type Subtype PubMed ID
dgv3172n71 CNV Loss 21882294
esv33998 OTHER Inversion 15654335

Variation tolerance for TUBG1 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBG1 Gene

HapMap Linkage Disequilibrium report
TUBG1
Human Gene Mutation Database (HGMD)
TUBG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBG1 Gene

Disorders for TUBG1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TUBG1 Gene - From: OMIM, ClinVar, GeneTests, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
cortical dysplasia, complex, with other brain malformations 4
  • cdcbm4
subcortical band heterotopia
  • subcortical laminar heterotopia
pachygyria
  • broad gyri of cerebrum
- elite association - COSMIC cancer census association via MalaCards
Search TUBG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TBG1_HUMAN
  • Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients. {ECO:0000269 PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TUBG1

Genetic Association Database (GAD)
TUBG1
Human Genome Epidemiology (HuGE) Navigator
TUBG1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBG1
genes like me logo Genes that share disorders with TUBG1: view

No data available for Genatlas for TUBG1 Gene

Publications for TUBG1 Gene

  1. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. (PMID: 1904010) Zheng Y. … Oakley B.R. (Cell 1991) 2 3 4 23 67
  2. A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome. (PMID: 20224777) Manning J.A. … Kumar S. (PLoS ONE 2010) 3 23
  3. Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast. (PMID: 19215229) Niu Y. … Zhang F. (Cancer Sci. 2009) 3 23
  4. Axin localizes to the centrosome and is involved in microtubule nucleation. (PMID: 19390532) Fumoto K. … Kikuchi A. (EMBO Rep. 2009) 3 23
  5. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. (PMID: 19543530) Haren L. … Lueders J. (PLoS ONE 2009) 3 23

Products for TUBG1 Gene

Sources for TUBG1 Gene

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