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TUBG1 Gene

protein-coding   GIFtS: 69
GCID: GC17P040761

Tubulin, Gamma 1

(Previous names: tubulin, gamma polypeptide)
(Previous symbol: TUBG)
  See TUBG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Gamma 11 2     CDCBM42 5
TUBG1 2 3     TUBGCP12
Tubulin, Gamma Polypeptide1 2     Tubulin Gamma-1 Chain2
Gamma-Tubulin Complex Component 12 3     Gamma-1-tubulin3
GCP-12 3     

External Ids:    HGNC: 124171   Entrez Gene: 72832   Ensembl: ENSG000001314627   OMIM: 1911355   UniProtKB: P232583   

Export aliases for TUBG1 gene to outside databases

Previous GC identifers: GC17P040369 GC17P042949 GC17P040670 GC17P041134 GC17P038015 GC17P036525


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TUBG1 Gene:
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it
binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates
microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene
of this gene is found on chromosome 7. (provided by RefSeq, Jan 2009)

GeneCards Summary for TUBG1 Gene:
TUBG1 (tubulin, gamma 1) is a protein-coding gene. Diseases associated with TUBG1 include cortical dysplasia, complex, with other brain malformations 4, and cortical dysplasia, complex, with other brain malformations. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.

UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation

summary for TUBG1 Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBG1 gene promoter:
         NF-1   NF-1/L   AML1a   Tal-1beta   GATA-1   COMP1   Zic1   ZIC2/Zic2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBG1 promoter sequence
   Search Chromatin IP Primers for TUBG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.31

TUBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBG1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040761:  view genomic region     (about GC identifiers)

Start:
40,761,358 bp from pter      End:
40,767,256 bp from pter
Size:
5,899 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258 (See protein sequence)
Recommended Name: Tubulin gamma-1 chain  
Size: 451 amino acids; 51170 Da
Subunit: Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the
interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO
Mass spectrometry: Mass=51197.98; Method=MALDI; Range=1-451; Source=PubMed:11840567;
3 PDB 3D structures from and Proteopedia for TUBG1:
1Z5V (3D)        1Z5W (3D)        3CB2 (3D)    
Secondary accessions: Q53X79 Q9BW59

Explore the universe of human proteins at neXtProt for TUBG1: NX_P23258

Explore proteomics data for TUBG1 at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of
    gamma-tubulin and its associated proteins from the cytoplasm to the centrosome (By similarity)1
  • Ubiquitination2 at Lys287, Lys301, Lys344
  • Modification sites at PhosphoSitePlus

  • See TUBG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001061.2  
    ENSEMBL proteins: 
     ENSP00000251413   ENSP00000464867   ENSP00000465582  
    Reactome Protein details: P23258

    TUBG1 Human Recombinant Protein Products:

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    Novus Biologicals TUBG1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TUBG1
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TUBG1 

     
    antibodies-online proteins for TUBG1 (10 products) 

     
    Search antibodies-online for peptides for TUBG1

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    antibodies-online antibodies for TUBG1 (62 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 7):
     IPR002454 Gamma_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry P23258

    ProtoNet protein and cluster: P23258

    1 Blocks protein domain: IPB002454 Gamma tubulin signature

    UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBG1_HUMAN, P23258
    Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing
    centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates
    alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation

         Genatlas biochemistry entry for TUBG1:
    tubulin,gamma polypeptide,universal component of microtubule organizing center,associated with centrosome (nb

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton TAS1904010
    GO:0005515protein binding IPI14594945
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with TUBG1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TUBG1:
     Decreased Wnt reporter activit  Decreased viability with pacli  Metaphase cells 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tubg1):
     cellular  embryogenesis  mortality/aging 

    Find genes that share phenotypes with TUBG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tubg1tm1Sts for TUBG1

       genOway: Develop your customized and physiologically relevant rodent model for TUBG1

    miRNA
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    miRTarBase miRNAs that target TUBG1:
    hsa-mir-187-3p (MIRT047028), hsa-mir-148b-3p (MIRT043581), hsa-mir-324-3p (MIRT042839), hsa-mir-1229-3p (MIRT036349), hsa-mir-99a-5p (MIRT048681), hsa-mir-26a-5p (MIRT050164)

    Block miRNA regulation of human, mouse, rat TUBG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUBG1 (see all 10):
    hsa-miR-3910 hsa-miR-520f hsa-miR-339-5p hsa-miR-124 hsa-miR-199a-5p hsa-miR-670 hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmidTUBG1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TUBG1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TUBG1 (NM_001070)
    Sino Biological Human cDNA Clone for TUBG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBG1
    Addgene plasmids for TUBG1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBG1_HUMAN, P23258: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material IEA--
    GO:0000794condensed nuclear chromosome ISS--
    GO:0000930gamma-tubulin complex TAS9566969
    GO:0005737cytoplasm ISS--
    GO:0005813centrosome IDA17286961

    Find genes that share ontologies with TUBG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBG1 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    Recruitment of NuMA to mitotic centrosomes0.00
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    4Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    5ERK Signaling
    Molecular Mechanisms of Cancer0.51


    Find genes that share SuperPaths with TUBG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBG1 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Epithelial Adherens Junctions
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for TUBG1
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for TUBG1
        Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Neurofilaments

    1 BioSystems Pathway for TUBG1
        PLK1 signaling events


    5 Reactome Pathways for TUBG1
        Recruitment of mitotic centrosome proteins and complexes
    Loss of proteins required for interphase microtubule organization,from the centrosome
    Regulation of PLK1 Activity at G2/M Transition
    Recruitment of NuMA to mitotic centrosomes
    Loss of Nlp from mitotic centrosomes


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBG1
    Interactions:

        GeneGlobe Interaction Network for TUBG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBG1 (P232581, 2, 3 ENSP000002514134) via UniProtKB, MINT, STRING, and/or I2D (see all 977)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151691, 2, 3, ENSP000002623204EBI-302589,EBI-710484 MINT-7229816 MINT-7229788 MINT-7229797 MINT-7229778 I2D: score=1 STRING: ENSP00000262320
    PLK1P533502, 3, ENSP000003000934MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000300093
    TUBB4BP683712, 3, ENSP000003412894MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000341289
    GSK3BP498412, 3, ENSP000003248064MINT-4051287 MINT-4051230 I2D: score=1 STRING: ENSP00000324806
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-7945693 MINT-6173837 I2D: score=1 STRING: ENSP00000307387
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000212meiotic spindle organization ISS--
    GO:0000226microtubule cytoskeleton organization TAS1904010
    GO:0000278mitotic cell cycle TAS--
    GO:0006184GTP catabolic process ----

    Find genes that share ontologies with TUBG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TUBG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 DrugBank Compound for TUBG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vinblastine-- 865-21-4targetadduct14619954 9664292 1818332 15579115 18220533

    Selected Novoseek inferred chemical compound relationships for TUBG1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 79.8 21 11093584 (3), 8824733 (2), 8089179 (1), 17705289 (1) (see all 14)
    colcemid 53.8 2 19226218 (1)
    gtp 38.5 12 15917813 (2), 18388201 (2), 8104191 (1), 7820871 (1) (see all 5)
    sucrose 35.6 15 7622595 (1), 9186012 (1), 11003675 (1), 12696185 (1) (see all 10)
    paclitaxel 33.2 7 11093584 (3), 8640766 (1), 18485433 (1), 9258503 (1) (see all 5)
    colchicine 31.8 3 7553905 (2), 9523151 (1)
    dimethylarsinic acid 25.9 5 11035156 (2), 11804606 (2)
    gdp 17 3 10037793 (1), 18388201 (1)
    mgatp 10.2 1 7622595 (1)
    tyrosine 3.16 9 15242776 (4), 18636972 (2), 19564412 (1), 19748892 (1) (see all 5)



    Find genes that share compounds with TUBG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUBG1 gene: 
    NM_001070.4  

    Unigene Cluster for TUBG1:

    Tubulin, gamma 1
    Hs.279669  [show with all ESTs]
    Unigene Representative Sequence: NM_001070
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251413(uc002ian.3) ENST00000588056 ENST00000591509 ENST00000589688
    ENST00000589613
    miRNA
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    hsa-miR-3910 hsa-miR-520f hsa-miR-339-5p hsa-miR-124 hsa-miR-199a-5p hsa-miR-670 hsa-miR-199b-5p hsa-miR-506
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    Addgene plasmids for TUBG1 
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      QuantiTect SYBR Green Assays in human, mouse, rat TUBG1
      QuantiFast Probe-based Assays in human, mouse, rat TUBG1

    Additional mRNA sequence: 

    AK310562.1 AK311637.1 AK313339.1 BC000619.2 BT019931.1 CR407642.1 M61764.1 

    Selected DOTS entries (see all 28):

    DT.100762577  DT.449247  DT.102838254  DT.92455259  DT.102838251  DT.114725  DT.120999000  DT.95165537 
    DT.95165540  DT.95204633  DT.100850368  DT.100872582  DT.120999043  DT.120999102  DT.120999106  DT.40288992 
    DT.91661394  DT.92455251  DT.95183389  DT.100658714  DT.120999002  DT.120999047  DT.86850962  DT.92455238 

    Selected AceView cDNA sequences (see all 691):

    AW614585 BQ549473 BE794061 CD358628 BE700697 BQ426110 BM451103 BX401159 
    BE207048 R55513 BM846639 CD251583 BU194909 BM662694 AI373574 CR611393 
    BM763367 BE275845 CR605839 BP382160 BG481146 AW304199 AI627426 BE258251 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBG1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                                -                                                                                       
    SP2:                                -                                                                                       
    SP3:                                                                                                                        
    SP4:                                                                                -     -                                 
    SP5:                                            -     -     -                                                               


    ECgene alternative splicing isoforms for TUBG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTCTCTGT
    TUBG1 Expression
    About this image


    TUBG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
             Encapsulated choroid plexus cells (NTCELL)
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TUBG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279669
        Custom PCR Arrays for TUBG1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBG1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubg11 , 5 tubulin, gamma 11, 5 92.76(n)1
    98.89(a)1
      11 (64.24 cM)5
    1037331  NM_134024.21  NP_598785.11 
     1011199385 
    chicken
    (Gallus gallus)
    Aves TUBG11 tubulin, gamma 1 85.21(n)
    98.59(a)
      420025  XM_418146.4  XP_418146.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    33(a)
    many ↔ many
    AAWZ02037584(28-15405)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.58712 X.laevis gamma-tubulin mRNA, complete cds 80.13(n)    M63446.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc558942 similar to tubulin, gamma 1 83.48(n)   393882  BC045486.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta gammaTub37C1 , 3 microtubule-based process structural
    constituent more3
    gamma-Tubulin at 37C1
    77(a)
    (best of 2)3
    71.45(n)1
    78.25(a)1
      37C73
    351991  NM_001273636.11  NP_001260565.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB4(YLR212C)4 Gamma-tubulin, involved in nucleating microtubules more   --   12(566281-564860) 850909  NP_013313.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons GCP21 GCP2 65.41(n)
    75.56(a)
      830445  NM_120644.2  NP_196181.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01566001 Os05g0156600 67.04(n)
    75.56(a)
      4337861  NM_001061233.1  NP_001054698.1 


    ENSEMBL Gene Tree for TUBG1 (if available)
    TreeFam Gene Tree for TUBG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBG1 gene
    TUBG22  TUBD12  
    Selected SIMAP similar genes for TUBG1 using alignment to 3 protein entries:     TBG1_HUMAN (see all proteins) (see all similar genes):
    TUBG2    TUBB2A    TUBB6    TUBB4A    TUBB2B    TUBB1
    TUBB2C    TUBB4B    TUBB8    TUBB3    DKFZp566F223    TUBB
    TUBB4Q    MGC16703    TUBA1B    TUBA1A    DKFZp686L04275    TUBA1C

    Find genes that share paralogs with TUBG1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TUBG1
    PGOHUM00000233209


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBG1 (see all 133)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0705774
    Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)4--see VAR_0705772 Y C mis40--------
    VAR_0705794
    Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)4--see VAR_0705792 L P mis40--------
    VAR_0705784
    Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)4--see VAR_0705782 T P mis40--------
    rs1923216581,2
    --40763517(+) CCTTCA/GTTGTA 1 -- int10--------
    rs784591011,2
    F--40763531(+) ATGAGG/AAAACT 1 -- int11Minor allele frequency- A:0.09WA 118
    rs1448367341,2
    --40763622(+) TAATCC/GTAGCA 1 -- int10--------
    rs1387579601,2
    --40763747(+) CATGCA/GCCTAT 1 -- int10--------
    rs1843888421,2
    --40763768(+) ACTGGA/GGAGGC 1 -- int10--------
    rs1893218371,2
    --40763958(+) TCTCAA/GTGTAG 1 -- int10--------
    rs1999482281,2
    C--40764192(+) GAGCCA/GACATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TUBG1 (40761358 - 40767256 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TUBG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3172n71CNV Loss21882294
    esv33998OTHER Inversion15654335

    Human Gene Mutation Database (HGMD): TUBG1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBG1
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191135   
    OMIM disorders: 615412  
    UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
  • Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412]: A disorder of
    aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures,
    microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior
    or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for TUBG1:    
    About MalaCards
    cortical dysplasia, complex, with other brain malformations 4    cortical dysplasia, complex, with other brain malformations    anaplastic astrocytoma


    Find genes that share disorders with TUBG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TUBG1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma ductal 25 1 16606540 (1)
    glioblastoma 15.1 14 17406983 (4), 16772870 (3), 20162618 (2)
    breast cancer 12.3 5 20009567 (3), 14506732 (1)
    anaplastic astrocytoma 9.49 1 17406983 (1)
    carcinoma 6.74 6 16606540 (2), 19131428 (1), 19215229 (1), 12866024 (1) (see all 5)
    tumors 5.09 17 20009567 (2), 20162618 (2), 12750257 (2), 19328337 (1) (see all 8)
    breast carcinoma 2.62 1 16606540 (1)
    astrocytoma 0 5 17406983 (3), 16772870 (2)
    shock 0 6 8464918 (2), 8886893 (1), 7782067 (1), 19748892 (1)
    primary tumor 0 2 16772870 (1)

    Genetic Association Database (GAD): TUBG1
    Human Genome Epidemiology (HuGE) Navigator: TUBG1 (2 documents)

    Export disorders for TUBG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBG1 gene, integrated from 10 sources (see all 310):
    (articles sorted by number of sources associating them with TUBG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. (PubMed id 1904010)1, 2, 3, 9 Zheng Y.... Oakley B.R. (Cell 1991)
    2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PubMed id 9566969)1, 2, 9 Tassin A.-M.... Bornens M. (J. Cell Biol. 1998)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (Proteomics 2002)
    6. The gamma-tubulin gene family in humans. (PubMed id 10903841)1, 9 Wise D.O.... Oakley B.R. (Genomics 2000)
    7. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. (PubMed id 7592789)1, 9 Kapeller R....Carpenter C.L. (J. Biol. Chem. 1995)
    8. A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome. (PubMed id 20224777)1, 9 Manning J.A....Kumar S. (PLoS ONE 2010)
    9. Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. (PubMed id 17406983)1, 9 Katsetos C.D....DrA!ber P. (Neurochem. Res. 2007)
    10. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. (PubMed id 15917813)1, 9 Aldaz H....Agard D.A. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7283 HGNC: 12417 AceView: TUBG1andTUBG2 Ensembl:ENSG00000131462 euGenes: HUgn7283
    ECgene: TUBG1 H-InvDB: TUBG1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TUBG1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TUBG1 gene:
    Search GeneIP for patents involving TUBG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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