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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBG1 Gene

protein-coding   GIFtS: 64
GCID: GC17P040761

tubulin, gamma 1

(Previous names: tubulin, gamma polypeptide )
(Previous symbol: TUBG)
 Explore 23 diseases affiliated with
TUBG1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TUBG1    

Aliases
for TUBG1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tubulin, Gamma 11 2     GCP-12 3
TUBG1 2 3     Gamma-1-Tubulin1
TUBGCP11 2     Tubulin Gamma-1 Chain2
Tubulin, Gamma Polypeptide1 2     Gamma-1-Tubulin1
Gamma-Tubulin Complex Component 12 3     

External Ids:    HGNC: 124171   Entrez Gene: 72832   Ensembl: ENSG000001314627   OMIM: 1911355   UniProtKB: P232583   

Export aliases for TUBG1 gene to outside databases

Previous GC identifers: GC17P040369 GC17P042949 GC17P040670 GC17P041134 GC17P038015 GC17P036525


Summaries
for TUBG1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TUBG1:
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds
to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule
nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is
found on chromosome 7. (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers
(MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain
minus-end nucleation, centrosome duplication and spindle formation

summary for TUBG1:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




Genomic Views
for TUBG1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBG1 gene promoter:
         NF-1   NF-1/L   AML1a   Tal-1beta   GATA-1   COMP1   Zic1   ZIC2/Zic2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUBG1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBG1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21   Ensembl cytogenetic band:  17q21.2   HGNC cytogenetic band: 17q21.31

TUBG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBG1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P040761:  view genomic region     (about GC identifiers)

Start:
 40,761,358 bp from pter      End:
 40,767,256 bp from pter
Size:
 5,899 bases      Orientation:
 plus strand

Proteins
for TUBG1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258 (See protein sequence)
Recommended Name: Tubulin gamma-1 chain  
Size: 451 amino acids; 51170 Da
Subunit: Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the
interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO
Subcellular location: Cytoplasm, cytoskeleton, centrosome
Mass spectrometry: Mass=51197.98; Method=MALDI; Range=1-451; Source=PubMed:11840567;
3 PDB 3D structures from and Proteopedia for TUBG1:
1Z5V (3D)        1Z5W (3D)        3CB2 (3D)    
Secondary accessions: Q53X79 Q9BW59

Explore the universe of human proteins at neXtProt for TUBG1: NX_P23258

Post-translational modifications:

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin
    • and its associated proteins from the cytoplasm to the centrosome (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P23258

    • TUBG1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001061.2  
    ENSEMBL proteins: 
     ENSP00000251413   ENSP00000464867   ENSP00000465582  
    Reactome Protein details: P23258
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for TUBG1
    Browse Proteins at Uscn

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material ----
    GO:0000794condensed nuclear chromosome ISS--
    GO:0000930gamma-tubulin complex TAS9566969
    GO:0005737cytoplasm ISS--
    GO:0005813centrosome IDA--


    TUBG1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TUBG1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TUBG1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR002454 Gamma_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry P23258

    ProtoNet protein and cluster: P23258

    1 Blocks protein family: IPB002454 Gamma tubulin signature

    UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
    Similarity: Belongs to the tubulin family


    Function
    for TUBG1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TBG1_HUMAN, P23258
    Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers
    (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain
    minus-end nucleation, centrosome duplication and spindle formation

         Genatlas biochemistry entry for TUBG1:
    tubulin,gamma polypeptide,universal component of microtubule organizing center,associated with centrosome (nb

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBG1
    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TUBG1 (see all 10):
    hsa-miR-3910 hsa-miR-520f hsa-miR-339-5p hsa-miR-124 hsa-miR-199a-5p hsa-miR-670 hsa-miR-199b-5p hsa-miR-506
    SwitchGear 3'UTR luciferase reporter plasmid: TUBG1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBG1 (see all 7)
    OriGene shRNA RFP: TUBG1
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBG1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TUBG1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBG1 (see all 3)
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton TAS1904010
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--


    TUBG1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for TUBG1:
     Decreased Wnt reporter activit  Decreased viability with pacli  Metaphase cells 

    Animal Models:
         Mouse knock-out Tubg1tm1Sts for TUBG1
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tubg1):
     cellular  embryogenesis  mortality/aging 

    TUBG1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TUBG1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Recruitment of mitotic centrosome proteins and complexes
    		Recruitment of mitotic centrosome proteins and complexes1.00
    		Mitotic G2-G2/M phases0.81
    		Centrosome maturation1.00
    		Loss of proteins required for interphase microtubule organization from the centrosome0.78
    		G2/M Transition0.83
    		Loss of Nlp from mitotic centrosomes0.78
    2Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    		Germ Cell-Sertoli Cell Junction Dynamics0.38
    3Cell Cycle
    		Cell Cycle1.00
    		Cell Cycle, Mitotic0.84
    4Cytoskeleton remodeling Neurofilaments
    		Cytoskeleton remodeling Neurofilaments1.00
    		Cytoskeleton remodeling_Neurofilaments0.91
    5Cytoskeleton remodeling Keratin filaments
    		Cytoskeleton remodeling Keratin filaments1.00
    		Cytoskeleton remodeling_Keratin filaments0.91

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TUBG1
        Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Keratin filaments

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TUBG1 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Epithelial Adherens Junctions
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for TUBG1
        Cytoskeletal Signaling

    2 GeneGo (Thomson Reuters) Pathways for TUBG1
        Cytoskeleton remodeling Keratin filaments
    Cytoskeleton remodeling Neurofilaments

    1 BioSystems Pathway for TUBG1 
        PLK1 signaling events

    5/9        Reactome Pathways for TUBG1 (see all 9)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes
    G2/M Transition



    TUBG1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUBG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/840 Interacting proteins for TUBG1 (P232581, 2, 3 ENSP000002514134) via UniProtKB, MINT, STRING, and/or I2D (see all 840)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AXIN1O151692, 3, ENSP000002623204MINT-7229816 MINT-7229788 MINT-7229797 MINT-7229778 I2D: score=1 STRING: ENSP00000262320
    PLK1P533502, 3, ENSP000003000934MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000300093
    TUBB4BP683712, 3, ENSP000003412894MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000341289
    GSK3BP498412, 3, ENSP000003248064MINT-4051287 MINT-4051230 I2D: score=1 STRING: ENSP00000324806
    PDCD6IPQ8WUM42, 3, ENSP000003073874MINT-7945693 MINT-6173837 I2D: score=1 STRING: ENSP00000307387
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000212meiotic spindle organization ISS--
    GO:0000226microtubule cytoskeleton organization TAS1904010
    GO:0000278mitotic cell cycle TAS--
    GO:0051258protein polymerization IEA--


    TUBG1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TUBG1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TUBG1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TUBG1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    XRP44XRas-Net pathway inhibitor[729605-21-4]
    TaxolPromotes assembly and inhibits disassembly of microtubules[33069-62-4]
    Vincristine sulfateDisrupts microtubules[2068-78-2]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    NocodazoleMicrotubule inhibitor[31430-18-9]

    1 DrugBank Compound for TUBG1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vinblastine-- 865-21-4targetadduct14619954 9664292 1818332 15579115 18220533

    10/15 Novoseek chemical compound relationships for TUBG1 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nocodazole 79.8 21 11093584 (3), 8824733 (2), 8089179 (1), 17705289 (1) (see all 14)
    colcemid 53.8 2 19226218 (1)
    gtp 38.5 12 15917813 (2), 18388201 (2), 8104191 (1), 7820871 (1) (see all 5)
    sucrose 35.6 15 7622595 (1), 9186012 (1), 11003675 (1), 12696185 (1) (see all 10)
    paclitaxel 33.2 7 11093584 (3), 8640766 (1), 18485433 (1), 9258503 (1) (see all 5)
    colchicine 31.8 3 7553905 (2), 9523151 (1)
    dimethylarsinic acid 25.9 5 11035156 (2), 11804606 (2)
    gdp 17 3 10037793 (1), 18388201 (1)
    mgatp 10.2 1 7622595 (1)
    tyrosine 3.16 9 15242776 (4), 18636972 (2), 19564412 (1), 19748892 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about TUBG1 / TBG1 

    Transcripts
    for TUBG1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section
    REFSEQ mRNAs for TUBG1 gene: 
    NM_001070.4  

    Unigene Cluster for TUBG1:

    Tubulin, gamma 1
    Hs.279669  [show with all ESTs]
    Unigene Representative Sequence: NM_001070
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251413(uc002ian.3) ENST00000588056 ENST00000591509 ENST00000589688
    ENST00000589613

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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TUBG1 (see all 10):
    hsa-miR-3910 hsa-miR-520f hsa-miR-339-5p hsa-miR-124 hsa-miR-199a-5p hsa-miR-670 hsa-miR-199b-5p hsa-miR-506
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    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK310562.1 AK311637.1 AK313339.1 BC000619.2 BT019931.1 CR407642.1 M61764.1 

    24/28 DOTS entries (see all 28):

    DT.100762577  DT.449247  DT.102838254  DT.92455259  DT.102838251  DT.114725  DT.120999000  DT.95165537 
    DT.95165540  DT.95204633  DT.100850368  DT.100872582  DT.120999043  DT.120999102  DT.120999106  DT.40288992 
    DT.91661394  DT.92455251  DT.95183389  DT.100658714  DT.120999002  DT.120999047  DT.86850962  DT.92455238 

    24/691 AceView cDNA sequences (see all 691):

    BQ549473 BF946086 CR592407 CD358628 AL539078 BP382160 CR604804 CR605839 
    BE275845 BM763367 BM662694 CR611393 CD251583 R55513 AI373574 BM846639 
    BU194909 BE207048 BX401159 BQ426110 BG481146 BM451103 AW304199 AA306399 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TUBG1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
    SP1:                                -                                                                                       
    SP2:                                -                                                                                       
    SP3:                                                                                                                        
    SP4:                                                                                -     -                                 
    SP5:                                            -     -     -                                                               


    ECgene alternative splicing isoforms for TUBG1

    Expression
    for TUBG1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GACTCTCTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TUBG1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TUBG1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUBG1

    SOURCE GeneReport for Unigene cluster: Hs.279669
        SABiosciences Custom PCR Arrays for TUBG1
    Primer
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    In Situ
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    Orthologs
    for TUBG1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBG1 gene from 7/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TUBG11 tubulin, gamma 1 85.21(n)
    98.59(a)    		   420025  XM_418146.3  XP_418146.3 
    lizard
    (Anolis carolinensis)    		 Reptilia TUBG26
    		 --
    		 95(a)
    		 1 → many
    		 6(61805157-61823982)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.58712 X.laevis gamma-tubulin mRNA, complete cds 80.13(n)    M63446.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc558942 similar to tubulin, gamma 1 83.48(n)   393882  BC045486.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta &ggr;Tub23C3
    gammaTub37C1    		 microtubule-based process structural
    constituent more3
    gamma-Tubulin at 37C1    		 77(a)
    (best of 2)3
    71.45(n)1
    78.25(a)1    		   351991  NM_057574.41  NP_476922.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons GCP21 tubulin gamma-2 chain 65.41(n)
    75.56(a)    		   830445  NM_120644.2  NP_196181.1 
    rice
    (Oryza sativa)    		 Liliopsida Os05g01566001 hypothetical protein 67.04(n)
    75.56(a)    		   4337861  NM_001061233.1  NP_001054698.1 


    ENSEMBL Gene Tree for TUBG1 (if available)
    TreeFam Gene Tree for TUBG1 (if available) 

    Paralogs
    for TUBG1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBG1 gene
    TUBG22  TUBD12  
    18/28 SIMAP similar genes for TUBG1 using alignment to 3 protein entries:     TBG1_HUMAN (see all proteins) (see all similar genes):
    TUBG2    TUBB2A    TUBB6    TUBB2B    TUBB1    TUBB2C
    TUBB4B    TUBB3    DKFZp566F223    TUBB4A    TUBB8    TUBB
    TUBB4Q    MGC16703    TUBA1B    DKFZp686L04275    TUBA1C    TUBA3E

    TUBG1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TUBG1
    PGOHUM00000233209


    Genomic Variants
    for TUBG1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/169 NCBI SNPs in TUBG1 are shown (see all 169)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 17 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs116512461,2
    		C,F,H,--36524529(+) ACTACT/GGTGAC 2 -- int118Minor allele frequency- G:0.07NS EA NA 1762
    rs47930391,2
    		C,F,A,H,--36524826(+) CCTCCA/GTTACA 2 -- int119Minor allele frequency- G:0.16NS EA NA WA 2224
    rs751442191,2
    		F,--36525072(+) TTACAA/GTCACA 2 -- int11Minor allele frequency- G:0.04WA 118
    rs620783931,2
    		--36525570(+) GGTGAG/AGCAAA 2 -- int12Minor allele frequency- A:0.02NA 122
    rs1131034211,2
    		--36525578(+) AAAATC/TAGGCA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1176728061,2
    		C,F,--36526622(+) CTTCTT/CATCCC 2 -- us2k11Minor allele frequency- C:0.02NA 120
    rs798435831,2
    		F,--36527315(+) GAGACC/GTGGCT 2 -- us2k11Minor allele frequency- G:0.04WA 118
    rs606098151,2
    		--36527691(+) ATTCTA/CCTGCC 2 -- us2k10--------
    rs1811259931,2
    		--40759380(+) AAGCAC/TGATGA 1 -- us2k10--------
    rs609298121,2
    		C,--40759448(+) AGGAAG/ATGGAA 1 -- us2k14Minor allele frequency- A:0.29NA WA EA 360

    HapMap Linkage Disequilibrium report for TUBG1 (40761358 - 40767256 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TUBG1: --

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    Disorders / Diseases
    for TUBG1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TUBG1 for disorders           About GeneDecksing

    OMIM gene information: 191135    OMIM disorders: --

    20/23 diseases for TUBG1 (see all 23):    About MalaCards
    inclusion body myositis    nijmegen breakage syndrome    myofibrillar myopathy    anaplastic astrocytoma
    retinitis pigmentosa    myositis    astrocytoma    squamous cell carcinoma
    embryonal carcinoma    myopathy    parkinson's disease    breast cancer
    glioblastoma    carcinoma    medulloblastoma    retinitis
    ovarian cancer    pancreatic cancer    pancreatitis    sarcoma

    10/15 Novoseek disease relationships for TUBG1 gene (see all 15)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carcinoma ductal 25 1 16606540 (1)
    glioblastoma 15.1 14 17406983 (4), 16772870 (3), 20162618 (2)
    breast cancer 12.3 5 20009567 (3), 14506732 (1)
    anaplastic astrocytoma 9.49 1 17406983 (1)
    carcinoma 6.74 6 16606540 (2), 19131428 (1), 19215229 (1), 12866024 (1) (see all 5)
    tumors 5.09 17 20009567 (2), 20162618 (2), 12750257 (2), 19328337 (1) (see all 8)
    breast carcinoma 2.62 1 16606540 (1)
    astrocytoma 0 5 17406983 (3), 16772870 (2)
    shock 0 6 8464918 (2), 8886893 (1), 7782067 (1), 19748892 (1)
    primary tumor 0 2 16772870 (1)

    Human Genome Epidemiology (HuGE) Navigator: TUBG1 (2 documents)

    Export disorders for TUBG1 gene to outside databases

    Publications
    for TUBG1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBG1 gene, integrated from 9 sources (see all 297):
    (articles sorted by number of sources associating them with TUBG1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. (PubMed id 1904010)1, 2, 3, 9 Zheng Y.... Oakley B.R. (1991)
    2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PubMed id 9566969)1, 2, 9 Tassin A.-M.... Bornens M. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)
    5. The gamma-tubulin gene family in humans. (PubMed id 10903841)1, 9 Wise D.O.... Oakley B.R. (2000)
    6. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. (PubMed id 7592789)1, 9 Kapeller R....Carpenter C.L. (1995)
    7. A Direct interaction with NEDD1 regulates gamma-tubul in recruitment to the centrosome. (PubMed id 20224777)1, 9 Manning J.A....Kumar S. (2010)
    8. Class III beta-tubulin and gamma-tubulin are co-expressed and form complexes in human glioblastoma cells. (PubMed id 17406983)1, 9 Katsetos C.D....Draber P. (2007)
    9. Insights into microtubule nucleation from the crystal structure of human gamma-tubulin. (PubMed id 15917813)1, 9 Aldaz H....Agard D.A. (2005)
    10. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. (PubMed id 19543530)1, 9 Haren L....LA1ders J. (2009)

    External Searches for TUBG1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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    Genome Databases showing TUBG1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7283 HGNC: 12417 AceView: TUBG1andTUBG2 Ensembl:ENSG00000131462 euGenes: HUgn7283
    ECgene: TUBG1 H-InvDB: TUBG1

    Other Databases showing TUBG1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TUBG1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBG1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TUBG1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TUBG1 gene:
    Search GeneIP for patents involving TUBG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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