Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TUBG1 Gene

Aliases for TUBG1 Gene

  • Tubulin Gamma 1 2 3 5
  • Gamma-Tubulin Complex Component 1 3 4
  • Tubulin, Gamma Polypeptide 2 3
  • GCP-1 3 4
  • TUBG 3 4
  • Tubulin Gamma-1 Chain 3
  • Tubulin, Gamma 1 2
  • Gamma-1-Tubulin 4
  • TUBGCP1 3
  • CDCBM4 3

External Ids for TUBG1 Gene

Previous HGNC Symbols for TUBG1 Gene

  • TUBG

Previous GeneCards Identifiers for TUBG1 Gene

  • GC17P040369
  • GC17P042949
  • GC17P040670
  • GC17P041134
  • GC17P038015
  • GC17P040761
  • GC17P036525

Summaries for TUBG1 Gene

Entrez Gene Summary for TUBG1 Gene

  • This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]

GeneCards Summary for TUBG1 Gene

TUBG1 (Tubulin Gamma 1) is a Protein Coding gene. Diseases associated with TUBG1 include Cortical Dysplasia, Complex, With Other Brain Malformations 4 and Pachygyria. Among its related pathways are PAK Pathway and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.

UniProtKB/Swiss-Prot for TUBG1 Gene

  • Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

Tocris Summary for TUBG1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Additional gene information for TUBG1 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBG1 Gene

Genomics for TUBG1 Gene

GeneHancer (GH) Regulatory Elements for TUBG1 Gene

Promoters and enhancers for TUBG1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I042607 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 0.0 -3 3.1 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 PIR53494 RETREG3 TUBG1 TUBG2 DHX8 ENSG00000267758 HMGN1P29 PSMC3IP STAT5A PSME3
GH17I042672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +69.4 69358 11.4 MLX ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 CNTNAP1 CCR10 PLEKHH3 ENSG00000267042 TUBG2 HSD17B1P1 ENSG00000267002 HMGN1P29 HMGN2P15 ENSG00000259623
GH17I042576 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 -31.2 -31156 4.2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 GC17P042577 GC17P042580 PSMC3IP DHX8 HMGN1P29 ENSG00000267758 TUBG2 NBR2 MLX STAT5A
GH17I042666 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.9 +58.1 58131 2.1 PKNOX1 MLX KLF17 SIN3A RAD21 RFX5 YY1 GLIS2 SCRT2 RCOR1 CNTNAP1 TUBG2 TUBG1 RETREG3 PSMC3IP HMGN2P15 RAMP2 RAMP2-AS1 VPS25 PIR45597
GH17I042660 Enhancer 1.1 ENCODE dbSUPER 11 +51.7 51680 1.5 HDAC1 PKNOX1 ARNT ZNF2 ZEB1 ZNF366 RCOR1 FOS ATF7 SMARCC1 TUBG2 MLX RETREG3 TUBG1 PIR45597
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TUBG1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBG1 gene promoter:

Genomic Locations for TUBG1 Gene

Genomic Locations for TUBG1 Gene
chr17:42,609,340-42,615,238
(GRCh38/hg38)
Size:
5,899 bases
Orientation:
Plus strand
chr17:40,761,358-40,767,256
(GRCh37/hg19)

Genomic View for TUBG1 Gene

Genes around TUBG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBG1 Gene

Proteins for TUBG1 Gene

  • Protein details for TUBG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23258-TBG1_HUMAN
    Recommended name:
    Tubulin gamma-1 chain
    Protein Accession:
    P23258
    Secondary Accessions:
    • Q53X79
    • Q9BW59

    Protein attributes for TUBG1 Gene

    Size:
    451 amino acids
    Molecular mass:
    51170 Da
    Quaternary structure:
    • Interacts with TUBGCP2 and TUBGCP3 (PubMed:9566969, PubMed:9566969). Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2 (PubMed:17959831). Interacts with PIFO (PubMed:20643351). Interacts with SAS6 and NUP62 at the centrosome (PubMed:24107630).

    Three dimensional structures from OCA and Proteopedia for TUBG1 Gene

neXtProt entry for TUBG1 Gene

Post-translational modifications for TUBG1 Gene

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.

Other Protein References for TUBG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBG1 Gene

Domains & Families for TUBG1 Gene

Gene Families for TUBG1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TUBG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23258

UniProtKB/Swiss-Prot:

TBG1_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBG1: view

Function for TUBG1 Gene

Molecular function for TUBG1 Gene

GENATLAS Biochemistry:
tubulin,gamma polypeptide,universal component of microtubule organizing center,associated with centrosome (nb
UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

Phenotypes From GWAS Catalog for TUBG1 Gene

Gene Ontology (GO) - Molecular Function for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS 1904010
GO:0005515 protein binding IPI 9566969
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBG1: view
genes like me logo Genes that share phenotypes with TUBG1: view

Human Phenotype Ontology for TUBG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TUBG1 Gene

MGI Knock Outs for TUBG1:

Clone Products

  • Addgene plasmids for TUBG1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TUBG1 Gene

Localization for TUBG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBG1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBG1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
endosome 5
extracellular 1

Gene Ontology (GO) - Cellular Components for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material IEA --
GO:0000794 condensed nuclear chromosome ISS,IEA --
GO:0000930 gamma-tubulin complex IEA,TAS 9566969
GO:0005737 cytoplasm ISS --
GO:0005813 centrosome IDA,IEA 17286961
genes like me logo Genes that share ontologies with TUBG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TUBG1 Gene

Pathways & Interactions for TUBG1 Gene

genes like me logo Genes that share pathways with TUBG1: view

SIGNOR curated interactions for TUBG1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000212 meiotic spindle organization IEA,ISS --
GO:0000226 microtubule cytoskeleton organization TAS 1904010
GO:0007017 microtubule-based process IEA --
GO:0007020 microtubule nucleation IEA --
genes like me logo Genes that share ontologies with TUBG1: view

Drugs & Compounds for TUBG1 Gene

(11) Drugs for TUBG1 Gene - From: DrugBank, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 439
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(9) Additional Compounds for TUBG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TUBG1 Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBG1: view

Transcripts for TUBG1 Gene

Unigene Clusters for TUBG1 Gene

Tubulin, gamma 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for TUBG1

Alternative Splicing Database (ASD) splice patterns (SP) for TUBG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: -
SP3:
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for TUBG1 Gene

GeneLoc Exon Structure for
TUBG1
ECgene alternative splicing isoforms for
TUBG1

Expression for TUBG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBG1 Gene

mRNA differential expression in normal tissues according to GTEx for TUBG1 Gene

This gene is overexpressed in Testis (x6.4).

Protein differential expression in normal tissues from HIPED for TUBG1 Gene

This gene is overexpressed in Breast (34.7) and Bone (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBG1 Gene



Protein tissue co-expression partners for TUBG1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBG1 Gene:

TUBG1

SOURCE GeneReport for Unigene cluster for TUBG1 Gene:

Hs.279669

Evidence on tissue expression from TISSUES for TUBG1 Gene

  • Skin(4.3)
  • Nervous system(4.2)
  • Lung(2.7)
  • Kidney(2.1)
  • Muscle(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBG1 Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
  • skeleton
Organs:
Head and neck:
  • brain
  • head
  • skull
genes like me logo Genes that share expression patterns with TUBG1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TUBG1 Gene

Orthologs for TUBG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBG1 34 33
  • 99.48 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBG1 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBG1 33 34
  • 94.01 (n)
dog
(Canis familiaris)
Mammalia TUBG1 33
  • 93.87 (n)
mouse
(Mus musculus)
Mammalia Tubg1 33 16 34
  • 92.76 (n)
rat
(Rattus norvegicus)
Mammalia Tubg1 33
  • 92.68 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 90 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 98 (a)
OneToMany
TUBG1 33
  • 85.21 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 33 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tubg1 33
  • 80.71 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5871 33
zebrafish
(Danio rerio)
Actinopterygii tubg1 33 34
  • 83.3 (n)
zgc55894 33
fruit fly
(Drosophila melanogaster)
Insecta gammaTub23C 35 34
  • 77 (a)
gammaTub37C 35 33 34
  • 71.45 (n)
worm
(Caenorhabditis elegans)
Secernentea tbg-1 35
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 34 36
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons GCP2 33
  • 65.41 (n)
rice
(Oryza sativa)
Liliopsida Os05g0156600 33
  • 67.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 83 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03954 33
  • 66.97 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtb1 33
  • 61.85 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9986 33
Species where no ortholog for TUBG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBG1 Gene

ENSEMBL:
Gene Tree for TUBG1 (if available)
TreeFam:
Gene Tree for TUBG1 (if available)

Paralogs for TUBG1 Gene

Paralogs for TUBG1 Gene

Pseudogenes.org Pseudogenes for TUBG1 Gene

genes like me logo Genes that share paralogs with TUBG1: view

Variants for TUBG1 Gene

Sequence variations from dbSNP and Humsavar for TUBG1 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs398123045 pathogenic, Cortical dysplasia, complex, with other brain malformations 4, Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412] 42,614,845(+) T/C coding_sequence_variant, missense_variant
rs398123046 pathogenic, Cortical dysplasia, complex, with other brain malformations 4, Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412] 42,610,535(+) A/G coding_sequence_variant, missense_variant
rs398123047 pathogenic, Cortical dysplasia, complex, with other brain malformations 4, Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412] 42,614,407(+) A/C coding_sequence_variant, missense_variant
rs1057518249 likely-pathogenic, not provided 42,614,520(+) C/T coding_sequence_variant, missense_variant
rs370373585 likely-benign, not provided 42,612,524(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBG1 Gene

Variant ID Type Subtype PubMed ID
esv33998 OTHER inversion 15654335
nsv1146669 OTHER inversion 26484159
nsv960107 CNV duplication 23825009

Variation tolerance for TUBG1 Gene

Residual Variation Intolerance Score: 24.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUBG1 Gene

Human Gene Mutation Database (HGMD)
TUBG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBG1 Gene

Disorders for TUBG1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for TUBG1 Gene - From: HGMD, OMIM, ClinVar, GTR, Swiss-Prot, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TUBG1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TBG1_HUMAN
  • Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients. {ECO:0000269 PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for TUBG1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TUBG1: view

No data available for Genatlas for TUBG1 Gene

Publications for TUBG1 Gene

  1. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. (PMID: 1904010) Zheng Y … Oakley BR (Cell 1991) 2 3 4 22 58
  2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PMID: 9566969) Tassin AM … Bornens M (The Journal of cell biology 1998) 3 4 22 58
  3. Nucleoporin Nup62 maintains centrosome homeostasis. (PMID: 24107630) Hashizume C … Wong RW (Cell cycle (Georgetown, Tex.) 2013) 3 4 58
  4. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson JE … Couch FJ (Breast cancer research and treatment 2011) 3 44 58
  5. A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome. (PMID: 20224777) Manning JA … Kumar S (PloS one 2010) 3 22 58

Products for TUBG1 Gene

Sources for TUBG1 Gene

Content
Loading form....