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Aliases for TUBG1 Gene

Aliases for TUBG1 Gene

  • Tubulin, Gamma 1 2 3
  • Gamma-Tubulin Complex Component 1 3 4
  • Tubulin, Gamma Polypeptide 2 3
  • CDCBM4 3 6
  • GCP-1 3 4
  • TUBG 3 4
  • Tubulin Gamma-1 Chain 3
  • Gamma-1-Tubulin 4
  • TUBGCP1 3

External Ids for TUBG1 Gene

Previous HGNC Symbols for TUBG1 Gene

  • TUBG

Previous GeneCards Identifiers for TUBG1 Gene

  • GC17P040369
  • GC17P042949
  • GC17P040670
  • GC17P041134
  • GC17P038015
  • GC17P040761
  • GC17P036525

Summaries for TUBG1 Gene

Entrez Gene Summary for TUBG1 Gene

  • This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7. [provided by RefSeq, Jan 2009]

GeneCards Summary for TUBG1 Gene

TUBG1 (Tubulin, Gamma 1) is a Protein Coding gene. Diseases associated with TUBG1 include cortical dysplasia, complex, with other brain malformations 4 and cortical dysplasia, complex, with other brain malformations. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.

UniProtKB/Swiss-Prot for TUBG1 Gene

  • Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation

Tocris Summary for TUBG1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBG1 Gene

Genomics for TUBG1 Gene

Regulatory Elements for TUBG1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUBG1 Gene

Start:
42,609,340 bp from pter
End:
42,615,238 bp from pter
Size:
5,899 bases
Orientation:
Plus strand

Genomic View for TUBG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBG1 Gene

Proteins for TUBG1 Gene

  • Protein details for TUBG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23258-TBG1_HUMAN
    Recommended name:
    Tubulin gamma-1 chain
    Protein Accession:
    P23258
    Secondary Accessions:
    • Q53X79
    • Q9BW59

    Protein attributes for TUBG1 Gene

    Size:
    451 amino acids
    Molecular mass:
    51170 Da
    Quaternary structure:
    • Interacts with TUBGCP2 and TUBGCP3. Interacts with B9D2 (By similarity). Interacts with CDK5RAP2; the interaction is leading to centrosomal localization of TUBG1 and CDK5RAP2. Interacts with PIFO.

    Three dimensional structures from OCA and Proteopedia for TUBG1 Gene

neXtProt entry for TUBG1 Gene

Proteomics data for TUBG1 Gene at MOPED

Post-translational modifications for TUBG1 Gene

  • Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
  • Ubiquitination at Lys287, Lys301, and Lys344
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBG1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TUBG1 (TUBG1)

No data available for DME Specific Peptides for TUBG1 Gene

Domains for TUBG1 Gene

Gene Families for TUBG1 Gene

HGNC:
  • TUB :Tubulins

Suggested Antigen Peptide Sequences for TUBG1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23258

UniProtKB/Swiss-Prot:

TBG1_HUMAN :
  • P23258
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBG1: view

Function for TUBG1 Gene

Molecular function for TUBG1 Gene

GENATLAS Biochemistry: tubulin,gamma polypeptide,universal component of microtubule organizing center,associated with centrosome (nb
UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation

Gene Ontology (GO) - Molecular Function for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS 1904010
GO:0005515 protein binding IPI 14594945
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBG1: view
genes like me logo Genes that share phenotypes with TUBG1: view

Animal Models for TUBG1 Gene

MGI Knock Outs for TUBG1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TUBG1 Gene

Localization for TUBG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBG1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBG1 Gene COMPARTMENTS Subcellular localization image for TUBG1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material --
GO:0000794 condensed nuclear chromosome ISS --
GO:0000930 gamma-tubulin complex TAS 9566969
GO:0005737 cytoplasm ISS --
GO:0005813 centrosome IDA 17286961
genes like me logo Genes that share ontologies with TUBG1: view

Pathways for TUBG1 Gene

genes like me logo Genes that share pathways with TUBG1: view

Gene Ontology (GO) - Biological Process for TUBG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000212 meiotic spindle organization ISS --
GO:0000226 microtubule cytoskeleton organization TAS 1904010
GO:0000278 mitotic cell cycle TAS --
GO:0006184 obsolete GTP catabolic process --
genes like me logo Genes that share ontologies with TUBG1: view

Compounds for TUBG1 Gene

(5) Tocris Compounds for TUBG1 Gene

Compound Action Cas Number
ABT 751 Inhibitor of microtubule polymerization; antimitotic and antitumor [141430-65-1]
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Harmine Potent and selective Dyrk1A inhibitor [442-51-3]
Vinblastine sulfate Disrupts microtubules [143-67-9]

(1) Drugbank Compounds for TUBG1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vinblastine
865-21-4 target adduct

(15) Novoseek inferred chemical compound relationships for TUBG1 Gene

Compound -log(P) Hits PubMed IDs
nocodazole 79.8 17
colcemid 53.8 1
gtp 38.5 7
sucrose 35.6 10
paclitaxel 33.2 7
genes like me logo Genes that share compounds with TUBG1: view

Transcripts for TUBG1 Gene

Unigene Clusters for TUBG1 Gene

Tubulin, gamma 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBG1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBG1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: -
SP2: -
SP3:
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for TUBG1 Gene

GeneLoc Exon Structure for
TUBG1
ECgene alternative splicing isoforms for
TUBG1

Expression for TUBG1 Gene

mRNA expression in normal human tissues for TUBG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TUBG1 Gene

This gene is overexpressed in Testis (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBG1 Gene

SOURCE GeneReport for Unigene cluster for TUBG1 Gene Hs.279669

genes like me logo Genes that share expressions with TUBG1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TUBG1 Gene

Orthologs for TUBG1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBG1 35
  • 99.48 (n)
  • 100 (a)
TUBG1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBG1 35
  • 94.01 (n)
  • 99.33 (a)
TUBG1 36
  • 99 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TUBG1 35
  • 93.87 (n)
  • 98 (a)
mouse
(Mus musculus)
Mammalia Tubg1 35
  • 92.76 (n)
  • 98.89 (a)
Tubg1 16
Tubg1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBG1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 90 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tubg1 35
  • 92.68 (n)
  • 98.89 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 98 (a)
OneToMany
TUBG1 35
  • 85.21 (n)
  • 98.59 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
ManyToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.5871 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tubg1 35
  • 80.71 (n)
  • 98.45 (a)
zebrafish
(Danio rerio)
Actinopterygii tubg1 35
  • 83.3 (n)
  • 98 (a)
tubg1 36
  • 98 (a)
OneToMany
zgc55894 35
fruit fly
(Drosophila melanogaster)
Insecta gammaTub23C 36
  • 75 (a)
ManyToMany
gammaTub37C 35
  • 71.45 (n)
  • 78.25 (a)
gammaTub37C 36
  • 76 (a)
ManyToMany
gammaTub23C 37
  • 77 (a)
gammaTub37C 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea tbg-1 37
  • 43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 36
  • 37 (a)
OneToMany
TUB4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons GCP2 35
  • 65.41 (n)
  • 75.56 (a)
rice
(Oryza sativa)
Liliopsida Os05g0156600 35
  • 67.04 (n)
  • 75.56 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03954 35
  • 66.97 (n)
  • 68.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes gtb1 35
  • 61.85 (n)
  • 71.56 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9986 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 83 (a)
OneToMany
Species with no ortholog for TUBG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBG1 Gene

ENSEMBL:
Gene Tree for TUBG1 (if available)
TreeFam:
Gene Tree for TUBG1 (if available)

Paralogs for TUBG1 Gene

Paralogs for TUBG1 Gene

Pseudogenes.org Pseudogenes for TUBG1 Gene

genes like me logo Genes that share paralogs with TUBG1: view

Variants for TUBG1 Gene

Sequence variations from dbSNP and Humsavar for TUBG1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs572 -- 42,613,866(+) ATGTC(A/T)GCCAG reference, synonymous-codon
rs13663 - 42,614,922(+) AGGAC(A/G)TGTTC reference, missense
rs521358 -- 42,614,254(+) TGTCC(C/T)ATCAG intron-variant
rs523129 -- 42,614,435(+) ATCCC(A/G)CACCC intron-variant
rs1045710 -- 42,614,528(+) GAACG(C/G)AAGTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TUBG1 Gene

Variant ID Type Subtype PubMed ID
dgv3172n71 CNV Loss 21882294
esv33998 OTHER Inversion 15654335

Relevant External Links for TUBG1 Gene

HapMap Linkage Disequilibrium report
TUBG1
Human Gene Mutation Database (HGMD)
TUBG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBG1 Gene

Disorders for TUBG1 Gene

(1) OMIM Diseases for TUBG1 Gene (191135)

UniProtKB/Swiss-Prot

TBG1_HUMAN
  • Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4) [MIM:615412]: A disorder of aberrant neuronal migration and disturbed axonal guidance. Clinical features include early-onset seizures, microcephaly, spastic tetraplegia, and various malformations of cortical development, such as agyria, posterior or frontal pachygyria, thick cortex, and subcortical band heterotopia and thin corpus callosum in some patients. {ECO:0000269 PubMed:23603762}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(15) Novoseek inferred disease relationships for TUBG1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma ductal 25 1
glioblastoma 15.1 9
breast cancer 12.3 4
anaplastic astrocytoma 9.49 1
carcinoma 6.74 6

Relevant External Links for TUBG1

Genetic Association Database (GAD)
TUBG1
Human Genome Epidemiology (HuGE) Navigator
TUBG1
genes like me logo Genes that share disorders with TUBG1: view

Publications for TUBG1 Gene

  1. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. (PMID: 1904010) Zheng Y. … Oakley B.R. (Cell 1991) 2 3 4 23
  2. Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin. (PMID: 9566969) Tassin A.-M. … Bornens M. (J. Cell Biol. 1998) 3 4 23
  3. Identification of a gamma-tubulin-binding domain in BRCA1. (PMID: 11691781) Hsu L.C. … White R.L. (Cancer Res. 2001) 3 23
  4. Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin. (PMID: 7592789) Kapeller R. … Carpenter C.L. (J. Biol. Chem. 1995) 3 23
  5. Human 76p: a new protein member of the gamma-tubulin associated protein family. (PMID: 10562286) Fava F. … Wright M. (J. Cell Biol. 1999) 3 23

Products for TUBG1 Gene

  • Addgene plasmids for TUBG1

Sources for TUBG1 Gene

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