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Aliases for TUBE1 Gene

Aliases for TUBE1 Gene

  • Tubulin Epsilon 1 2 3 5
  • Epsilon-Tubulin 3 4
  • TUBE 3 4
  • Tubulin Epsilon Chain 3
  • Tubulin, Epsilon 1 2
  • DJ142L7.2 3

External Ids for TUBE1 Gene

Previous GeneCards Identifiers for TUBE1 Gene

  • GC06M112414
  • GC06M112437
  • GC06M112498
  • GC06M109966
  • GC06M112391

Summaries for TUBE1 Gene

Entrez Gene Summary for TUBE1 Gene

  • This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]

GeneCards Summary for TUBE1 Gene

TUBE1 (Tubulin Epsilon 1) is a Protein Coding gene. Diseases associated with TUBE1 include Chronic Frontal Sinusitis and Frontal Sinusitis. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and ERK Signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB8.

Tocris Summary for TUBE1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBE1 Gene

Genomics for TUBE1 Gene

Regulatory Elements for TUBE1 Gene

Enhancers for TUBE1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F112153 0.9 Ensembl ENCODE 15.4 -68.0 -67972 3.4 ZNF384 ZNF664 ZNF316 POLR2A SCRT2 PRDM10 NFE2 FOSL2 FOS MAFK TUBE1 FAM229B ENSG00000237234 RNU6-1226P GC06M112197
GH06F112149 0.8 FANTOM5 ENCODE 14.3 -62.7 -62666 2.0 CTCF ZFHX2 SCRT2 KLF4 WT1 NFE2L2 TUBE1 FAM229B ENSG00000255389 ENSG00000237234
GH06F112138 0.2 ENCODE 13.3 -51.9 -51891 0.9 PKNOX1 RAD51 PBX2 CEBPB USF2 MGA TUBE1 LOC100128588 ENSG00000255389 ENSG00000237234
GH06F112163 0.7 ENCODE 11.6 -76.0 -75966 0.2 CTCF ARID4B ZNF48 RAD21 GATAD1 ZNF143 SMC3 NR2F6 GATAD2A ZNF202 ENSG00000220506 MFSD4B FAM229B TUBE1 FCF1P5 RNU6-1226P ENSG00000272356 LAMA4 ENSG00000237234 GC06M112197
GH06F112030 0.8 Ensembl ENCODE 11 +56.8 56849 0.7 RING1 RNF2 HNF4G PRDM1 YY1 TUBE1 ENSG00000272356 WISP3 GC06M111982
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TUBE1 on UCSC Golden Path with GeneCards custom track

Promoters for TUBE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TUBE1 Gene

112,070,657 bp from pter
112,087,548 bp from pter
16,892 bases
Minus strand

Genomic View for TUBE1 Gene

Genes around TUBE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBE1 Gene

Proteins for TUBE1 Gene

  • Protein details for TUBE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin epsilon chain
    Protein Accession:
    Secondary Accessions:
    • Q5H8W8
    • Q8NEG3

    Protein attributes for TUBE1 Gene

    475 amino acids
    Molecular mass:
    52932 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBE1 Gene

Post-translational modifications for TUBE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBE1 Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for TUBE1

No data available for DME Specific Peptides for TUBE1 Gene

Domains & Families for TUBE1 Gene

Gene Families for TUBE1 Gene

Suggested Antigen Peptide Sequences for TUBE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tubulin family.
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBE1: view

Function for TUBE1 Gene

Gene Ontology (GO) - Molecular Function for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS 10620804
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBE1: view
genes like me logo Genes that share phenotypes with TUBE1: view

Animal Model Products

miRNA for TUBE1 Gene

miRTarBase miRNAs that target TUBE1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBE1 Gene

Localization for TUBE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBE1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with pericentriolar material.

Subcellular locations from

Jensen Localization Image for TUBE1 Gene COMPARTMENTS Subcellular localization image for TUBE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material TAS 10620804
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBE1: view

Pathways & Interactions for TUBE1 Gene

genes like me logo Genes that share pathways with TUBE1: view

Gene Ontology (GO) - Biological Process for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
GO:0007098 centrosome cycle TAS 10620804
genes like me logo Genes that share ontologies with TUBE1: view

No data available for SIGNOR curated interactions for TUBE1 Gene

Drugs & Compounds for TUBE1 Gene

(4) Drugs for TUBE1 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 413
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 111
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBE1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolastatin 10 trifluoroacetate

(5) Tocris Compounds for TUBE1 Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Docetaxel Microtubule stabilizer 114977-28-5
Dolastatin 10 trifluoroacetate Tubulin polymerization inhibitor
MMAE Potent dolastatin 10 analog; antitumor 474645-27-7
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBE1: view

Transcripts for TUBE1 Gene

Unigene Clusters for TUBE1 Gene

Tubulin, epsilon 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for TUBE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBE1 Gene

mRNA expression in normal human tissues for TUBE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBE1 Gene

This gene is overexpressed in Monocytes (48.2), Testis (10.9), and Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBE1 Gene

Protein tissue co-expression partners for TUBE1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TUBE1 Gene:


SOURCE GeneReport for Unigene cluster for TUBE1 Gene:

genes like me logo Genes that share expression patterns with TUBE1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TUBE1 Gene

Orthologs for TUBE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TUBE1 34 35
  • 99.72 (n)
(Canis familiaris)
Mammalia TUBE1 34 35
  • 91.09 (n)
(Mus musculus)
Mammalia Tube1 34 16 35
  • 85.4 (n)
(Bos Taurus)
Mammalia TUBE1 35
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia TUBE1 35
  • 84 (a)
(Rattus norvegicus)
Mammalia Tube1 34
  • 82.96 (n)
(Monodelphis domestica)
Mammalia TUBE1 35
  • 78 (a)
(Gallus gallus)
Aves TUBE1 34 35
  • 78.18 (n)
(Anolis carolinensis)
Reptilia TUBE1 35
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tube1 34
  • 74.59 (n)
(Danio rerio)
Actinopterygii tube1 34 35 35
  • 67.31 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG32396 35
  • 28 (a)
(Caenorhabditis elegans)
Secernentea tbb-6 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 67 (a)
Species where no ortholog for TUBE1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBE1 Gene

Gene Tree for TUBE1 (if available)
Gene Tree for TUBE1 (if available)

Paralogs for TUBE1 Gene

Paralogs for TUBE1 Gene Pseudogenes for TUBE1 Gene

genes like me logo Genes that share paralogs with TUBE1: view

Variants for TUBE1 Gene

Sequence variations from dbSNP and Humsavar for TUBE1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10456877 -- 112,078,547(+) CTGAT(C/T)ATCTG intron-variant
rs111322638 -- 112,071,671(+) TCATT(A/C)AGCTC intron-variant
rs111463573 -- 112,075,503(+) ACTAA(A/T)TTCCT intron-variant
rs111468306 -- 112,071,639(+) AAAAG(G/T)TAAAT intron-variant
rs11153335 -- 112,077,247(+) ATTAA(A/G)CATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBE1 Gene

Variant ID Type Subtype PubMed ID
esv3366325 CNV insertion 20981092
nsv950495 CNV duplication 24416366

Variation tolerance for TUBE1 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBE1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBE1 Gene

Disorders for TUBE1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TUBE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic frontal sinusitis
frontal sinusitis
laryngeal tuberculosis
  • tuberculosis, laryngeal
- elite association - COSMIC cancer census association via MalaCards
Search TUBE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TUBE1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TUBE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBE1 Gene

Publications for TUBE1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P. … Stearns T. (Nat. Cell Biol. 2000) 2 3 4 22 64
  2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Epsilon-tubulin is required for centriole duplication and microtubule organization. (PMID: 12510196) Chang P. … Stearns T. (Nat. Cell Biol. 2003) 3 22 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TUBE1 Gene

Sources for TUBE1 Gene

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