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TUBE1 Gene

protein-coding   GIFtS: 56
GCID: GC06M112391

Tubulin, Epsilon 1

  See TUBE1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Epsilon 11 2
TUBE2 3 5
dJ142L7.22
epsilon-tubulin2
Tubulin Epsilon Chain2
Epsilon-tubulin3

External Ids:    HGNC: 207751   Entrez Gene: 511752   Ensembl: ENSG000000749357   OMIM: 6073455   UniProtKB: Q9UJT03   

Export aliases for TUBE1 gene to outside databases

Previous GC identifers: GC06M112414 GC06M112437 GC06M112498 GC06M109966


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TUBE1 Gene:
This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal
appendages that are associated with the older of the two centrioles after centrosome duplication. This protein
plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene
is found on chromosome 5.(provided by RefSeq, Jan 2009)

GeneCards Summary for TUBE1 Gene:
TUBE1 (tubulin, epsilon 1) is a protein-coding gene. Diseases associated with TUBE1 include tracheitis, and frontal sinusitis. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is LOC260334.

summary for TUBE1 Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBE1 gene promoter:
         COUP-TF1   ER-alpha   NF-1   COUP   MyoD   HNF-4alpha2   HNF-4alpha1   CREB   COUP-TF   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBE1 promoter sequence
   Search Chromatin IP Primers for TUBE1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBE1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q21   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q21

TUBE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBE1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M112391:  view genomic region     (about GC identifiers)

Start:
112,391,860 bp from pter      End:
112,408,751 bp from pter
Size:
16,892 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBE_HUMAN, Q9UJT0 (See protein sequence)
Recommended Name: Tubulin epsilon chain  
Size: 475 amino acids; 52932 Da
Secondary accessions: Q5H8W8 Q8NEG3

Explore the universe of human proteins at neXtProt for TUBE1: NX_Q9UJT0

Explore proteomics data for TUBE1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TUBE1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057346.1  
    ENSEMBL proteins: 
     ENSP00000357651   ENSP00000474458   ENSP00000475087   ENSP00000474989  

    TUBE1 Human Recombinant Protein Products:

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    Novus Biologicals TUBE1 Protein
    Novus Biologicals TUBE1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TUBE1 

     
    antibodies-online proteins for TUBE1 (4 products) 

     
    antibodies-online peptides for TUBE1

    TUBE1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for TUBE1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TUBE1
    LSBio Antibodies in human, mouse, rat for TUBE1
    antibodies-online antibodies for TUBE1 (8 products) 

    TUBE1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TUBE1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TUBE1 
    antibodies-online kits for TUBE1 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 7):
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR004057 Epsilon_tubulin
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry Q9UJT0

    ProtoNet protein and cluster: Q9UJT0

    1 Blocks protein domain: IPB004057 Epsilon-tubulin signature

    UniProtKB/Swiss-Prot: TBE_HUMAN, Q9UJT0
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBE1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton TAS10620804
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with TUBE1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TUBE1:
     Decreased TP53 protein express  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBE1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBE1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUBE1

    miRNA
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    miRTarBase miRNAs that target TUBE1:
    hsa-mir-124-3p (MIRT022541)

    Block miRNA regulation of human, mouse, rat TUBE1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TUBE1:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUBE1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TUBE1
    Predesigned siRNA for gene silencing in human, mouse, rat TUBE1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TUBE1

    Clone
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    OriGene clones in human, mouse for TUBE1 (see all 7)
    OriGene ORF clones in mouse, rat for TUBE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBE1 (NM_016262)
    Sino Biological Human cDNA Clone for TUBE1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBE1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBE1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBE_HUMAN, Q9UJT0: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with
    pericentriolar material
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material IEA--
    GO:0005874microtubule IEA--
    GO:0043234protein complex ----

    Find genes that share ontologies with TUBE1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBE1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    2Nanog in Mammalian ESC Pluripotency
    14-3-3 Induced Intracellular Signaling0.59
    3ERK Signaling
    Molecular Mechanisms of Cancer0.51
    4PAK Pathway
    Epithelial Adherens Junctions0.36
    5G-Beta Gamma Signaling
    Hedgehog Signaling in Mammals0.32

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBE1 (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Epithelial Adherens Junctions
    Parkinson's Disease Pathway



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBE1
    Interactions:

        Search GeneGlobe Interaction Network for TUBE1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBE1 (ENSP000003576514) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SKIENSP000003677974STRING: ENSP00000367797
    KRT15ENSP000002540434STRING: ENSP00000254043
    KRT8ENSP000002933084STRING: ENSP00000293308
    STARD13ENSP000003387854STRING: ENSP00000338785
    KIF1AENSP000003227914STRING: ENSP00000322791
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007098centrosome cycle TAS10620804
    GO:0051258protein polymerization IEA--
    GO:0051297centrosome organization ----

    Find genes that share ontologies with TUBE1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TUBE1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 DrugBank Compound for TUBE1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vinblastine-- 865-21-4targetadduct14619954 9664292 1818332 15579115 18220533



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUBE1 gene: 
    NM_016262.4  

    Unigene Cluster for TUBE1:

    Tubulin, epsilon 1
    Hs.34851  [show with all ESTs]
    Unigene Representative Sequence: AK126191
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368662(uc003pvq.3) ENST00000604814 ENST00000605457 ENST00000603651
    ENST00000604743 ENST00000604689 ENST00000441191 ENST00000604967 ENST00000368657
    ENST00000603621 ENST00000603722
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TUBE1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TUBE1:
    hsa-miR-590-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUBE1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TUBE1
    Predesigned siRNA for gene silencing in human, mouse, rat TUBE1
    Clone
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    OriGene clones in human, mouse for TUBE1 (see all 7)
    OriGene ORF clones in mouse, rat for TUBE1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBE1 (NM_016262)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBE1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBE1
    Primer
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    OriGene qPCR primer pairs and template standards for TUBE1
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBE1
      QuantiTect SYBR Green Assays in human, mouse, rat TUBE1
      QuantiFast Probe-based Assays in human, mouse, rat TUBE1

    Additional mRNA sequence: 

    AF201334.1 AK026242.1 AK126191.1 BC025405.2 BC031101.1 

    12 DOTS entries:

    DT.412752  DT.65287297  DT.100666807  DT.91725620  DT.121321733  DT.206223  DT.311146  DT.86852069 
    DT.91725623  DT.95190331  DT.100727407  DT.92007628 

    Selected AceView cDNA sequences (see all 147):

    BM503814 AA768510 AL580253 BM998898 AW291894 AV658536 BC025405 BF058163 
    CA411886 BM264176 CB153775 AI805900 AI492047 AI333177 BG108376 AI284732 
    AL598964 AA927014 BG253224 BM509957 CR613971 AV660654 AK126191 N51701 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBE1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
    SP1:                                      -                 -                 -     -           -           -                           
    SP2:                                      -           -     -                 -     -           -           -                           
    SP3:                                      -                 -                 -     -                                                   
    SP4:                                      -                 -                                                                           
    SP5:                                      -           -     -                                                                           


    ECgene alternative splicing isoforms for TUBE1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBE1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTGTATT
    TUBE1 Expression
    About this image


    TUBE1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
    TUBE1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBE1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.34851
        Custom PCR Arrays for TUBE1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUBE1
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBE1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBE1
    QuantiTect SYBR Green Assays in human, mouse, rat TUBE1
    QuantiFast Probe-based Assays in human, mouse, rat TUBE1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBE1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TUBE1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tube11 , 5 epsilon-tubulin 11, 5 85.4(n)1
    91.16(a)1
      10 (20.16 cM)5
    719241  NM_028006.21  NP_082282.11 
     391340235 
    chicken
    (Gallus gallus)
    Aves TUBE11 tubulin, epsilon 1 78.18(n)
    84.63(a)
      421750  XM_419781.4  XP_419781.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUBE16
    tubulin, epsilon 1
    84(a)
    1 ↔ 1
    1(192573190-192597114)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tube11 tubulin, epsilon 1 74.59(n)
    81.1(a)
      100488997  NM_001016136.2  NP_001016136.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tube11 tubulin, epsilon 1 67.31(n)
    75.48(a)
      393960  NM_200985.2  NP_957279.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG323966
    --
    28(a)
    1 ↔ 1
    3L(6523829-6525529)
    worm
    (Caenorhabditis elegans)
    Secernentea tbb-66
    Protein TBB-6 (tbb-6) mRNA, complete cds
    30(a)
    1 ↔ 1
    V(12261804-12263368) WBGene00006539


    ENSEMBL Gene Tree for TUBE1 (if available)
    TreeFam Gene Tree for TUBE1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBE1 gene
    LOC2603342  TUBB8P72  TUBB2  TUBB4B2  TUBB4A2  TUBB82  TUBB2B2  TUBB32  
    TUBB62  TUBB2A2  ENSG000002589472  TUBB12  
    Selected SIMAP similar genes for TUBE1 using alignment to 3 protein entries:     TBE_HUMAN (see all proteins) (see all similar genes):
    TUBA1    TUBB4Q    TUBA1A    TUBB2B    TUBB3    TUBA1B
    TUBB8    DKFZp566F223    TUBB    TUBB2A    TUBB6    MGC16703
    TUBB1    TUBAL3    TUBB2C    TUBB4A    TUBB4B    TUBA8

    Find genes that share paralogs with TUBE1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBE1 (see all 353)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1474355661,2
    C--112391461(+) GGGAGA/GAAAAA 1 -- ds50010--------
    rs9715301,2
    C,F,A--112391474(+) ATACTA/CAATTT 1 -- ds500112Minor allele frequency- C:0.46NA WA CSA EA 538
    rs1127015381,2
    C,F--112391516(+) CTAAGG/ATGCCC 1 -- ds50012Minor allele frequency- A:0.08CSA WA 120
    rs9715311,2
    C,F,O,A,H--112391533(+) TGATAC/AATCAT 1 -- ds500129Minor allele frequency- A:0.34MN NS EA NA WA CSA 2850
    rs1121851511,2
    F--112391635(+) ATCAGC/TTTCTT 1 -- ds50011Minor allele frequency- T:0.00CSA 1
    rs1129676221,2
    F--112391824(+) ATAAAA/TTGTTA 1 -- ds50012Minor allele frequency- T:0.10CSA WA 120
    rs1167782031,2
    C,F--112391876(+) GTAACC/TGGAAC 1 -- ut311Minor allele frequency- T:0.04WA 118
    rs2011256321,2
    C--112391915(+) AGATA-/TCAAGC
            
    TCAAG
    1 -- cds10--------
    rs1427992841,2
    C--112391951(+) TAAATA/GTCATG 1 -- ut310--------
    rs771865661,2
    C,F--112391977(+) TAGCAC/TTGTTG 1 -- ut311Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for TUBE1 (112391860 - 112408751 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TUBE1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv274138CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBE1
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBE1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607345    OMIM disorders: --

    3 diseases for TUBE1:    
    About MalaCards
    tracheitis    frontal sinusitis    intestinal obstruction

    5 diseases from the University of Copenhagen DISEASES database for TUBE1:
    Frontal sinusitis     Japanese encephalitis     Intestinal obstruction     tick-borne encephalitis
    Tracheitis

    Find genes that share disorders with TUBE1           About GenesLikeMe

    Genetic Association Database (GAD): TUBE1
    Human Genome Epidemiology (HuGE) Navigator: TUBE1 (1 document)

    Export disorders for TUBE1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for TUBE1 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TUBE1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PubMed id 10620804)1, 2, 3, 9 Chang P. and Stearns T. (Nat. Cell Biol. 2000)
    2. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Epsilon-tubulin is required for centriole duplication and microtubule organization. (PubMed id 12510196)1, 9 Chang P....Stearns T. (Nat. Cell Biol. 2003)
    5. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. EB1 recognizes the nucleotide state of tubulin in the microtubule lattice. (PubMed id 19851462)1 Zanic M....Howard J. (PLoS ONE 2009)
    8. How do microtubule-targeted drugs work? An overview. (PubMed id 18220533)7 Jordan M.A. and Kamath K. (Curr Cancer Drug Targets 2007)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    10. Microtubulin binding sites as target for developing anticancer agents. (PubMed id 15579115)7 Islam M.N. and Iskander M.N. (Mini Rev Med Chem 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51175 HGNC: 20775 AceView: TUBE1 Ensembl:ENSG00000074935 euGenes: HUgn51175
    ECgene: TUBE1 H-InvDB: TUBE1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TUBE1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TUBE1 gene:
    Search GeneIP for patents involving TUBE1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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