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Aliases for TUBE1 Gene

Aliases for TUBE1 Gene

  • Tubulin Epsilon 1 2 3 5
  • Tubulin, Epsilon 1 2 3
  • Epsilon-Tubulin 3 4
  • TUBE 3 4
  • DJ142L7.2 3

External Ids for TUBE1 Gene

Previous GeneCards Identifiers for TUBE1 Gene

  • GC06M112414
  • GC06M112437
  • GC06M112498
  • GC06M109966
  • GC06M112391

Summaries for TUBE1 Gene

Entrez Gene Summary for TUBE1 Gene

  • This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]

GeneCards Summary for TUBE1 Gene

TUBE1 (Tubulin Epsilon 1) is a Protein Coding gene. Diseases associated with TUBE1 include Chronic Frontal Sinusitis and Frontal Sinusitis. Among its related pathways are ERK Signaling and Remodeling of Adherens Junctions. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB2B.

Tocris Summary for TUBE1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBE1 Gene

Genomics for TUBE1 Gene

Regulatory Elements for TUBE1 Gene

Enhancers for TUBE1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TUBE1 on UCSC Golden Path with GeneCards custom track

Promoters for TUBE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TUBE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBE1 Gene

Chromosome:
6
Start:
112,070,657 bp from pter
End:
112,087,548 bp from pter
Size:
16,892 bases
Orientation:
Minus strand

Genomic View for TUBE1 Gene

Genes around TUBE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBE1 Gene

Proteins for TUBE1 Gene

  • Protein details for TUBE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT0-TBE_HUMAN
    Recommended name:
    Tubulin epsilon chain
    Protein Accession:
    Q9UJT0
    Secondary Accessions:
    • Q5H8W8
    • Q8NEG3

    Protein attributes for TUBE1 Gene

    Size:
    475 amino acids
    Molecular mass:
    52932 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBE1 Gene

Proteomics data for TUBE1 Gene at MOPED

Post-translational modifications for TUBE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBE1 Gene

No data available for DME Specific Peptides for TUBE1 Gene

Domains & Families for TUBE1 Gene

Gene Families for TUBE1 Gene

Suggested Antigen Peptide Sequences for TUBE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJT0

UniProtKB/Swiss-Prot:

TBE_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBE1: view

Function for TUBE1 Gene

Gene Ontology (GO) - Molecular Function for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBE1: view
genes like me logo Genes that share phenotypes with TUBE1: view

Animal Model Products

miRNA for TUBE1 Gene

miRTarBase miRNAs that target TUBE1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBE1 Gene

Localization for TUBE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBE1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with pericentriolar material.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBE1 Gene COMPARTMENTS Subcellular localization image for TUBE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBE1: view

Pathways & Interactions for TUBE1 Gene

genes like me logo Genes that share pathways with TUBE1: view

Interacting Proteins for TUBE1 Gene

Gene Ontology (GO) - Biological Process for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
genes like me logo Genes that share ontologies with TUBE1: view

No data available for SIGNOR curated interactions for TUBE1 Gene

Drugs & Compounds for TUBE1 Gene

(4) Drugs for TUBE1 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 396
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 105
Taxol Approved August 1997 Pharma Agonist Promotes assembly and inhibits disassembly of microtubules 0
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0

(2) Additional Compounds for TUBE1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Vinblastine sulfate
143-67-9
Vincristine sulfate
2068-78-2

(5) Tocris Compounds for TUBE1 Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Nocodazole Microtubule inhibitor 31430-18-9
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
Vincristine sulfate Disrupts microtubules 2068-78-2
genes like me logo Genes that share compounds with TUBE1: view

Transcripts for TUBE1 Gene

Unigene Clusters for TUBE1 Gene

Tubulin, epsilon 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for TUBE1 Gene

GeneLoc Exon Structure for
TUBE1
ECgene alternative splicing isoforms for
TUBE1

Expression for TUBE1 Gene

mRNA expression in normal human tissues for TUBE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TUBE1 Gene

This gene is overexpressed in Monocytes (48.2), Testis (10.9), and Tlymphocyte (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBE1 Gene



SOURCE GeneReport for Unigene cluster for TUBE1 Gene Hs.34851

genes like me logo Genes that share expression patterns with TUBE1: view

Protein tissue co-expression partners for TUBE1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TUBE1 Gene

Orthologs for TUBE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBE1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TUBE1 35
  • 91.09 (n)
  • 93.26 (a)
TUBE1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tube1 35
  • 85.4 (n)
  • 91.16 (a)
Tube1 16
Tube1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBE1 35
  • 99.72 (n)
  • 99.79 (a)
TUBE1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tube1 35
  • 82.96 (n)
  • 90.23 (a)
cow
(Bos Taurus)
Mammalia TUBE1 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBE1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBE1 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUBE1 35
  • 78.18 (n)
  • 84.63 (a)
TUBE1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBE1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tube1 35
  • 74.59 (n)
  • 81.1 (a)
zebrafish
(Danio rerio)
Actinopterygii tube1 35
  • 67.31 (n)
  • 75.48 (a)
tube1 36
  • 75 (a)
OneToMany
tube1 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32396 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbb-6 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for TUBE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBE1 Gene

ENSEMBL:
Gene Tree for TUBE1 (if available)
TreeFam:
Gene Tree for TUBE1 (if available)

Paralogs for TUBE1 Gene

Paralogs for TUBE1 Gene

genes like me logo Genes that share paralogs with TUBE1: view

Variants for TUBE1 Gene

Sequence variations from dbSNP and Humsavar for TUBE1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6899727 -- 112,071,372(+) AAAAA(A/G)CAATG utr-variant-3-prime
rs9487816 -- 112,074,054(+) TTCCC(C/T)TTCTT intron-variant
rs1624814 -- 112,076,242(+) GAGAA(C/T)GTTTC intron-variant
rs1631968 -- 112,083,567(-) GCCGA(A/G)GCGGG intron-variant
rs1709865 -- 112,079,239(+) CATGA(A/G)CACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBE1 Gene

Variant ID Type Subtype PubMed ID
esv274138 CNV Insertion 20981092

Variation tolerance for TUBE1 Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TUBE1 Gene

Disorders for TUBE1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TUBE1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chronic frontal sinusitis
frontal sinusitis
- elite association - COSMIC cancer census association via MalaCards
Search TUBE1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TUBE1

Genetic Association Database (GAD)
TUBE1
Human Genome Epidemiology (HuGE) Navigator
TUBE1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBE1
genes like me logo Genes that share disorders with TUBE1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBE1 Gene

Publications for TUBE1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P. … Stearns T. (Nat. Cell Biol. 2000) 2 3 4 23 67
  2. Epsilon-tubulin is required for centriole duplication and microtubule organization. (PMID: 12510196) Chang P. … Stearns T. (Nat. Cell Biol. 2003) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PMID: 23463506) Perez-Hernandez D. … YA!A+ez-MA^ M. (J. Biol. Chem. 2013) 3
  5. Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity. (PMID: 23826228) He M. … Zhou J. (PLoS ONE 2013) 3

Products for TUBE1 Gene

Sources for TUBE1 Gene

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