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Aliases for TUBE1 Gene

Aliases for TUBE1 Gene

  • Tubulin, Epsilon 1 2 3
  • TUBE 3 4 6
  • Epsilon-Tubulin 3 4
  • Tubulin Epsilon Chain 3
  • DJ142L7.2 3

External Ids for TUBE1 Gene

Previous GeneCards Identifiers for TUBE1 Gene

  • GC06M112414
  • GC06M112437
  • GC06M112498
  • GC06M109966
  • GC06M112391

Summaries for TUBE1 Gene

Entrez Gene Summary for TUBE1 Gene

  • This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]

GeneCards Summary for TUBE1 Gene

TUBE1 (Tubulin, Epsilon 1) is a Protein Coding gene. Diseases associated with TUBE1 include tracheitis and frontal sinusitis. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB3.

Tocris Summary for TUBE1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

No data available for UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBE1 Gene

Genomics for TUBE1 Gene

Regulatory Elements for TUBE1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUBE1 Gene

Start:
112,070,657 bp from pter
End:
112,087,548 bp from pter
Size:
16,892 bases
Orientation:
Minus strand

Genomic View for TUBE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBE1 Gene

Proteins for TUBE1 Gene

  • Protein details for TUBE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT0-TBE_HUMAN
    Recommended name:
    Tubulin epsilon chain
    Protein Accession:
    Q9UJT0
    Secondary Accessions:
    • Q5H8W8
    • Q8NEG3

    Protein attributes for TUBE1 Gene

    Size:
    475 amino acids
    Molecular mass:
    52932 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBE1 Gene

Proteomics data for TUBE1 Gene at MOPED

Post-translational modifications for TUBE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBE1 Gene

No data available for DME Specific Peptides for TUBE1 Gene

Domains for TUBE1 Gene

Gene Families for TUBE1 Gene

HGNC:
  • TUB :Tubulins

Suggested Antigen Peptide Sequences for TUBE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UJT0

UniProtKB/Swiss-Prot:

TBE_HUMAN :
  • Q9UJT0
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBE1: view

Function for TUBE1 Gene

Gene Ontology (GO) - Molecular Function for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton TAS 10620804
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBE1: view
genes like me logo Genes that share phenotypes with TUBE1: view

Animal Model Products

miRNA for TUBE1 Gene

miRTarBase miRNAs that target TUBE1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBE1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBE1 Gene

Localization for TUBE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBE1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Associated with pericentriolar material.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBE1 Gene COMPARTMENTS Subcellular localization image for TUBE1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000242 pericentriolar material TAS 10620804
GO:0005874 microtubule IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with TUBE1: view

Pathways for TUBE1 Gene

genes like me logo Genes that share pathways with TUBE1: view

Interacting Proteins for TUBE1 Gene

Gene Ontology (GO) - Biological Process for TUBE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007017 microtubule-based process --
GO:0007098 centrosome cycle TAS 10620804
GO:0008152 metabolic process IEA --
GO:0051258 protein polymerization IEA --
genes like me logo Genes that share ontologies with TUBE1: view

Compounds for TUBE1 Gene

(5) Tocris Compounds for TUBE1 Gene

Compound Action Cas Number
ABT 751 Inhibitor of microtubule polymerization; antimitotic and antitumor [141430-65-1]
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Harmine Potent and selective Dyrk1A inhibitor [442-51-3]
Vinblastine sulfate Disrupts microtubules [143-67-9]

(1) Drugbank Compounds for TUBE1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vinblastine
865-21-4 target adduct
genes like me logo Genes that share compounds with TUBE1: view

Transcripts for TUBE1 Gene

Unigene Clusters for TUBE1 Gene

Tubulin, epsilon 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBE1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBE1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1: - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7:
SP8:

Relevant External Links for TUBE1 Gene

GeneLoc Exon Structure for
TUBE1
ECgene alternative splicing isoforms for
TUBE1

Expression for TUBE1 Gene

mRNA expression in normal human tissues for TUBE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBE1 Gene

SOURCE GeneReport for Unigene cluster for TUBE1 Gene Hs.34851

genes like me logo Genes that share expressions with TUBE1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TUBE1 Gene

Orthologs for TUBE1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUBE1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBE1 35
  • 99.72 (n)
  • 99.79 (a)
TUBE1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBE1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBE1 35
  • 91.09 (n)
  • 93.26 (a)
TUBE1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tube1 35
  • 85.4 (n)
  • 91.16 (a)
Tube1 16
Tube1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBE1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBE1 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tube1 35
  • 82.96 (n)
  • 90.23 (a)
chicken
(Gallus gallus)
Aves TUBE1 35
  • 78.18 (n)
  • 84.63 (a)
TUBE1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TUBE1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tube1 35
  • 74.59 (n)
  • 81.1 (a)
zebrafish
(Danio rerio)
Actinopterygii tube1 35
  • 67.31 (n)
  • 75.48 (a)
tube1 36
  • 75 (a)
OneToMany
tube1 36
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG32396 36
  • 28 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tbb-6 36
  • 30 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 67 (a)
OneToOne
Species with no ortholog for TUBE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBE1 Gene

ENSEMBL:
Gene Tree for TUBE1 (if available)
TreeFam:
Gene Tree for TUBE1 (if available)

Paralogs for TUBE1 Gene

genes like me logo Genes that share paralogs with TUBE1: view

Variants for TUBE1 Gene

Sequence variations from dbSNP and Humsavar for TUBE1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs971530 -- 112,070,271(+) ATACT(A/C)AATTT downstream-variant-500B
rs971531 -- 112,070,330(+) TGATA(A/C)ATCAT downstream-variant-500B
rs1624814 -- 112,076,242(+) GAGAA(C/T)GTTTC intron-variant
rs1631968 -- 112,083,567(-) GCCGA(A/G)GCGGG intron-variant
rs1709865 -- 112,079,239(+) CATGA(A/G)CACGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBE1 Gene

Variant ID Type Subtype PubMed ID
esv274138 CNV Insertion 20981092

Relevant External Links for TUBE1 Gene

HapMap Linkage Disequilibrium report
TUBE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBE1 Gene

Disorders for TUBE1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for TUBE1 Gene including...

Search for TUBE1 Gene in MalaCards »

Relevant External Links for TUBE1

Genetic Association Database (GAD)
TUBE1
Human Genome Epidemiology (HuGE) Navigator
TUBE1
genes like me logo Genes that share disorders with TUBE1: view

No data available for UniProtKB/Swiss-Prot for TUBE1 Gene

Publications for TUBE1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P. … Stearns T. (Nat. Cell Biol. 2000) 2 3 4 23
  2. Epsilon-tubulin is required for centriole duplication and microtubule organization. (PMID: 12510196) Chang P. … Stearns T. (Nat. Cell Biol. 2003) 3 23
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

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