External Ids for TUBE1 Gene
Previous GeneCards Identifiers for TUBE1 Gene
This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Jan 2009]
GeneCards Summary for TUBE1 Gene
TUBE1 (Tubulin, Epsilon 1) is a Protein Coding gene. Diseases associated with TUBE1 include chronic frontal sinusitis and frontal sinusitis. Among its related pathways are PAK Pathway and ERK Signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB3.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).