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Aliases & Descriptions for TUBE1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Epsilon-tubulin 3 | | FLJ22589 1, 2 | | FLJ44203 2 | | OTTHUMP00000017033 2 | | OTTHUMP00000040425 2 | | TUBE 1, 2, 3 | | dJ142L7.2 1, 2 |
| | | Descriptions |
|---|
| Tubulin epsilon chain 2 | | tubulin, epsilon 1 2 |
|
| | Search outside databases for aliases for TUBE1 genePrevious GC identifers: GC06M112414 GC06M112437 |
Summaries for TUBE1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TUBE1: This gene encodes a member of the tubulin superfamily. This protein localizes to the centriolar sub-distal appendages that are associated with the older of the two centrioles after centrosome duplication. This protein plays a central role in organization of the microtubules during centriole duplication. A pseudogene of this gene is found on chromosome 5.
|
Genomic Location for TUBE1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TUBE1 gene 
Entrez Gene cytogenetic band: 6q21 Ensembl cytogenetic band: 6q21 HGNC cytogenetic band: 6q21TUBE1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M112498:
(about GC identifiers)
Start:
|
112,498,673 bp from pter |
End:
|
112,515,375 bp from pter |
Size:
|
16,703 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_025741.14
| Proteins for TUBE1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TBE_HUMAN, Q9UJT0 (See
protein sequence)Recommended Name: Tubulin epsilon chain Size: 475 amino acids; 52932 Da
Subcellular location: Centrosome. Note=Associated with pericentriolar material
Secondary accessions: Q8NEG3REFSEQ proteins: NP_057346.1
ENSEMBL proteins: ENSP00000357651 ENSP00000357647 ENSP00000357646
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TUBE1 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TUBE1: Assays for TUBE1: | Protein
Domains/ Families for TUBE1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UJT0
ProtoNet protein and cluster: Q9UJT0 1 Blocks protein family: IPB004057 Epsilon-tubulin signature
UniProtKB/Swiss-Prot: TBE_HUMAN, Q9UJT0Similarity: Belongs to the tubulin family | Gene Function for TUBE1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016262
Applied Biosystems Silencer® siRNAs for TUBE1
Sigma-Aldrich siRNA and siRNA Panels for TUBE1  Sigma-Aldrich shRNA for TUBE1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016262                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016262                                  untagged cDNA clone in CMV expression vector: NM_016262 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016262
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TUBE1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for TUBE1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for TUBE1 |
Compounds for TUBE1 available from Tocris Bioscience About this table
|
Transcripts for TUBE1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016262
Sigma-Aldrich siRNA and siRNA Panels for TUBE1  Sigma-Aldrich shRNA for TUBE1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_016262 REFSEQ mRNAs for TUBE1 gene: NM_016262.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_016262               OriGene GFP tagged cDNA clone in CMV expression vector: NM_016262                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_016262                                  untagged cDNA clone in CMV expression vector: NM_016262  Additional cDNA sequence: AF201334.1 AK026242.1 AK126191.1 BC025405.2 BC031101.1 CR609343.1 CR613971.1 12 DOTS entries: DT.412752 DT.65287297 DT.100666807 DT.311146 DT.91725620 DT.121321733 DT.206223 DT.86852069 DT.91725623 DT.95190331 DT.100727407 DT.92007628 24/147 AceView cDNA sequences (see all 147
):CA411886 AF201334 BE221549 CR613971 AL580253 AI613127 BF058163 CB163568 AK026242 AA768510 AL598964 BM264176 AW294927 CB153775 BG108376 N22140 AA099692 AV658536 AI805900 AI243385 AK126191 BM509957 AL134732 AI492047
highest scoring ESTs for TUBE1:AA215502 AA973387 AF201334 AI302255 AI333177 AI492047 AI768712 AI801903 AK026242 AL580253 Unigene Cluster for TUBE1: Tubulin, epsilon 1 Hs.34851 [show with all ESTs]Unigene Representative Sequence: AK126191
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TUBE1 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TUBE1
3 Ensembl transcripts including schematic representations: ENST00000368662
ENST00000368658
ENST00000368657
|
Expression for TUBE1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TUBE1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TUBE1
1 / 2 / 3 5 probe-sets matching TUBE1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATTTGTATT
SOURCE GeneReport for Unigene cluster: Hs.34851
|
Orthologs for TUBE1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TUBE1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for TUBE1
ENSEMBL Gene Tree for TUBE1 | Paralogs for TUBE1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TUBE1 gene
- TUBG12 TUBG22 TUBD12
|
SNPs/Variants for TUBE1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TUBE1 (up to first 250kb)
|
Disorders & Mutations for TUBE1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607345
|
Medical News for TUBE1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TUBE1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for TUBE1 gene (see all 15
): |
Search for TUBE1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TUBE1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TUBE1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TUBE1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TUBE1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TUBE1:

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 |  |  |
| | | | Tocris compounds for TUBE1 |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|