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TUBD1 Gene

protein-coding   GIFtS: 57
GCID: GC17M057936

Tubulin, Delta 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Delta 11 2
TUBD2 3 5
delta-tubulin2
Tubulin Delta Chain2
Delta-tubulin3

External Ids:    HGNC: 168111   Entrez Gene: 511742   Ensembl: ENSG000001084237   OMIM: 6073445   UniProtKB: Q9UJT13   

Export aliases for TUBD1 gene to outside databases

Previous GC identifers: GC17M057786 GC17M060386 GC17M058278 GC17M058412 GC17M055291 GC17M053309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TUBD1 Gene:
TUBD1 (tubulin, delta 1) is a protein-coding gene. Diseases associated with TUBD1 include prostatic hypertrophy, and neuroblastoma. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot: TBD_HUMAN, Q9UJT1
Function: In the elongating spermatid it is associated with the manchette, a specialized microtubule system
present during reshaping of the sperm head (By similarity)

summary for TUBD1 Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBD1 gene promoter:
         NF-1/L   NF-1   POU3F2 (N-Oct-5a)   POU3F2   Evi-1   YY1   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBD1 promoter sequence
   Search Chromatin IP Primers for TUBD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.1   Ensembl cytogenetic band:  17q23.1   HGNC cytogenetic band: 17q23.1

TUBD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBD1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M057936:  view genomic region     (about GC identifiers)

Start:
57,936,840 bp from pter      End:
57,970,306 bp from pter
Size:
33,467 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TBD_HUMAN, Q9UJT1 (See protein sequence)
Recommended Name: Tubulin delta chain  
Size: 453 amino acids; 51034 Da
Secondary accessions: B4DPT8 B4DW01 D3DU02 E9PCA7 E9PCQ8 Q5KU36 Q9BWG9 Q9H7Z8
Alternative splicing: 6 isoforms:  Q9UJT1-1   Q9UJT1-2   Q9UJT1-3   Q9UJT1-4   Q9UJT1-5   Q9UJT1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TUBD1: NX_Q9UJT1

Explore proteomics data for TUBD1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys47, Lys79
  • Modification sites at PhosphoSitePlus

  • See TUBD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001180538.1  NP_001180539.1  NP_001180540.1  NP_001180541.1  NP_001180542.1  NP_057345.2  

    ENSEMBL proteins: 
     ENSP00000342561   ENSP00000342399   ENSP00000377785   ENSP00000365262   ENSP00000468518  
     ENSP00000441757   ENSP00000467915   ENSP00000466681   ENSP00000465579   ENSP00000467480  
     ENSP00000320797  

    TUBD1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TUBD1
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    Novus Biologicals TUBD1 Proteins
    Novus Biologicals TUBD1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    TUBD1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TUBD1
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    Novus Biologicals TUBD1 Antibodies
    Abcam antibodies for TUBD1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for TUBD1
    LSBio Antibodies in human, mouse, rat for TUBD1

    TUBD1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TUBD1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TUBD1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 6):
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR002967 Delta_tubulin
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry Q9UJT1

    ProtoNet protein and cluster: Q9UJT1

    1 Blocks protein domain: IPB002967 Delta tubulin signature

    UniProtKB/Swiss-Prot: TBD_HUMAN, Q9UJT1
    Similarity: Belongs to the tubulin family


    TUBD1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBD_HUMAN, Q9UJT1
    Function: In the elongating spermatid it is associated with the manchette, a specialized microtubule system
    present during reshaping of the sperm head (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005525GTP binding IEA--
         
    TUBD1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBD1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBD1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBD1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUBD1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TUBD1:
    hsa-mir-26b-5p (MIRT028800)

    Block miRNA regulation of human, mouse, rat TUBD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUBD1 (see all 10):
    hsa-miR-549 hsa-miR-600 hsa-miR-561 hsa-miR-545 hsa-miR-1179 hsa-miR-570 hsa-miR-514 hsa-miR-4310
    SwitchGear 3'UTR luciferase reporter plasmidTUBD1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TUBD1
    Predesigned siRNA for gene silencing in human, mouse, rat TUBD1

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TUBD1 (NM_001193612)
    Sino Biological Human cDNA Clone for TUBD1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBD1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TUBD1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBD_HUMAN, Q9UJT1: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm.
    Nucleus. Note=Associated with centrioles. Both cytoplasmic and nuclear
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol4
    golgi apparatus4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242pericentriolar material ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus ----

    TUBD1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBD1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    Germ Cell-Sertoli Cell Junction Dynamics0.38
    2ERK Signaling
    Molecular Mechanisms of Cancer0.51
    3PAK Pathway
    Epithelial Adherens Junctions0.36
    4G-Beta Gamma Signaling
    Hedgehog Signaling in Mammals0.32
    5Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBD1 (see all 7)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Epithelial Tight Junctions
    Germ Cell-Sertoli Cell Junction Dynamics



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBD1
    Interactions:

        Search GeneGlobe Interaction Network for TUBD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBD1 (Q9UJT13 ENSP000003207974) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SOCS6O145443I2D: score=1 
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    FAHENSP000002617554STRING: ENSP00000261755
    MAPRE1ENSP000003647214STRING: ENSP00000364721
    MAPRE2ENSP000003002494STRING: ENSP00000300249
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007017microtubule-based process IEA--
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    TUBD1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TUBD1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 DrugBank Compound for TUBD1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vinblastine-- 865-21-4targetadduct14619954 9664292 1818332 15579115 18220533



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TUBD1 gene (6 alternative transcripts): 
    NM_001193609.1  NM_001193610.1  NM_001193611.1  NM_001193612.1  NM_001193613.1  NM_016261.3  

    Unigene Cluster for TUBD1:

    Tubulin, delta 1
    Hs.463638  [show with all ESTs]
    Unigene Representative Sequence: NM_016261
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000346141(uc010ddi.2) ENST00000340993(uc010ddh.2 uc002ixx.2 uc010ddf.2)
    ENST00000394239 ENST00000376094 ENST00000592426 ENST00000539018 ENST00000591548
    ENST00000588009 ENST00000593110 ENST00000587476 ENST00000591611 ENST00000590498
    ENST00000588706 ENST00000592145 ENST00000325752(uc002ixw.2 uc010wok.2 uc010wol.2 uc010ddg.2)

    miRNA
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    Block miRNA regulation of human, mouse, rat TUBD1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUBD1 (see all 10):
    hsa-miR-549 hsa-miR-600 hsa-miR-561 hsa-miR-545 hsa-miR-1179 hsa-miR-570 hsa-miR-514 hsa-miR-4310
    SwitchGear 3'UTR luciferase reporter plasmidTUBD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TUBD1
    Predesigned siRNA for gene silencing in human, mouse, rat TUBD1
    Clone
    Products:
         
    OriGene clones in human, mouse for TUBD1 (see all 24)
    OriGene ORF clones in mouse, rat for TUBD1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): TUBD1 (NM_001193612)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBD1
    Primer
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    OriGene qPCR primer pairs and template standards for TUBD1
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBD1
      QuantiTect SYBR Green Assays in human, mouse, rat TUBD1
      QuantiFast Probe-based Assays in human, mouse, rat TUBD1

    Additional mRNA sequence: 

    AB030837.1 AB031044.1 AB031045.1 AF201333.1 AK022771.1 AK024096.1 AK024741.1 AK298492.1 
    AK301312.1 AK315172.1 BC000258.1 

    12 DOTS entries:

    DT.95362917  DT.100751359  DT.92425648  DT.100024805  DT.100770870  DT.120922374  DT.120922382  DT.100751360 
    DT.40282483  DT.99981059  DT.100672679  DT.100690674 

    Selected AceView cDNA sequences (see all 83):

    BQ128350 AI468299 BM310319 CD358419 AA370137 AB030837 BU782895 AL524265 
    AA848060 BU787499 BM972896 BX459984 W33134 BU856950 BU782928 BC000258 
    BE256242 BP375734 BX119803 BU860436 BQ416682 BQ549318 AF201333 BE254093 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBD1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
    SP1:                                                  -     -                                                                                 
    SP2:                                                  -     -                                   -     -                                       
    SP3:                                                  -     -                                   -     -     -                                 
    SP4:                                                  -     -                                                                                 
    SP5:                                -     -                 -                                                                                 


    ECgene alternative splicing isoforms for TUBD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBD1 expression in normal human tissues (normalized intensities)      TUBD1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TUBD1 Expression
    About this image


    TUBD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TUBD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.463638
        Custom PCR Arrays for TUBD1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUBD1
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBD1
    QuantiTect SYBR Green Assays in human, mouse, rat TUBD1
    QuantiFast Probe-based Assays in human, mouse, rat TUBD1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TUBD1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubd11 , 5 tubulin, delta 11, 5 84.33(n)1
    85.65(a)1
      11 (51.82 cM)5
    564271  NM_001199047.11  NP_001185976.11 
     865449915 
    chicken
    (Gallus gallus)
    Aves TUBD11 tubulin, delta 1 73.88(n)
    75.06(a)
      417636  XM_415881.4  XP_415881.1 
    lizard
    (Anolis carolinensis)
    Reptilia TUBD16
    tubulin, delta 1
    71(a)
    1 ↔ 1
    GL343470.1(217235-225039)
    African clawed frog
    (Xenopus laevis)
    Amphibia tubd1-A-prov2 delta-tubulin 75.72(n)    AF430839.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tubd11 tubulin, delta 1 62.78(n)
    60.76(a)
      415183  NM_001002093.1  NP_001002093.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tbg-16
    Protein TBG-1 (tbg-1) mRNA, complete cds
    20(a)
    1 ↔ 1
    III(9626033-9629154) WBGene00006540
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB46
    Gamma-tubulin, involved in nucleating microtubules...
    21(a)
    1 → many
    XII(564860-566281) YLR212C


    ENSEMBL Gene Tree for TUBD1 (if available)
    TreeFam Gene Tree for TUBD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBD1 gene
    TUBG12  TUBG22  
    5 SIMAP similar genes for TUBD1 using alignment to 5 protein entries:     TBD_HUMAN (see all proteins):
    TUBA1    TUBB6    TUBB4A    TUBG1    TUBB3

    TUBD1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBD1 (see all 715)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2020719341,2
    C--57936398(+) TCATTC/TTTTTT 6 -- int10--------
    rs72230571,2
    C,F--57936438(+) cacccG/Cggctg 6 -- int17Minor allele frequency- C:0.12NA WA EA 366
    rs1879677961,2
    --57936490(+) CCCAGA/GCTCAA 6 -- int10--------
    rs1118371921,2
    F--57936491(+) CCAGGG/CTCAAG 6 -- int11Minor allele frequency- C:0.00CSA 1
    rs1819523811,2
    --57936497(+) TCAAGG/TGATCC 6 -- int10--------
    rs1392971431,2
    C--57936651(+) TCCCAC/TTTTGC 6 -- int10--------
    rs1418015041,2
    C--57936828(+) AAGTAC/TACATT 6 -- int10--------
    rs1470857261,2
    C--57936863(+) CATAAC/GCATTT 6 -- ut310--------
    rs12982761,2
    C--57936909(-) CCACTC/TTAAGC 6 -- ut31 ese36Minor allele frequency- T:0.00EA NA MN 238
    rs1482285791,2
    C--57936965(+) AGCATC/TTGACA 6 -- ut310--------

    HapMap Linkage Disequilibrium report for TUBD1 (57936840 - 57970306 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TUBD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2716085CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBD1
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607344    OMIM disorders: --

    6 diseases for TUBD1:    About MalaCards
    prostatic hypertrophy    neuroblastoma    inflammatory bowel disease    obesity
    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for TUBD1:
    Prostatic hypertrophy

    TUBD1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TUBD1
    Human Genome Epidemiology (HuGE) Navigator: TUBD1 (5 documents)

    Export disorders for TUBD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBD1 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with TUBD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PubMed id 10620804)1, 2, 3, 9 Chang P. and Stearns T. (Nat. Cell Biol. 2000)
    2. Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis. (PubMed id 15081367)1, 2, 9 Kato A.... Todokoro K. (Dev. Biol. 2004)
    3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)1, 4 Olson J.E....Couch F.J. (Breast Cancer Res. Treat. 2011)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51174 HGNC: 16811 AceView: TUBD1 Ensembl:ENSG00000108423 euGenes: HUgn51174
    ECgene: TUBD1 H-InvDB: TUBD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TUBD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TUBD1 gene:
    Search GeneIP for patents involving TUBD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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