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Aliases for TUBD1 Gene

Aliases for TUBD1 Gene

  • Tubulin Delta 1 2 3 5
  • Delta-Tubulin 3 4
  • TUBD 3 4
  • Tubulin Delta Chain 3
  • Tubulin, Delta 1 2

External Ids for TUBD1 Gene

Previous GeneCards Identifiers for TUBD1 Gene

  • GC17M057786
  • GC17M060386
  • GC17M058278
  • GC17M058412
  • GC17M055291
  • GC17M057936
  • GC17M053309

Summaries for TUBD1 Gene

GeneCards Summary for TUBD1 Gene

TUBD1 (Tubulin Delta 1) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and ERK Signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG1.

UniProtKB/Swiss-Prot for TUBD1 Gene

  • In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Tocris Summary for TUBD1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBD1 Gene

Genomics for TUBD1 Gene

Regulatory Elements for TUBD1 Gene

Enhancers for TUBD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F059824 2.2 VISTA FANTOM5 Ensembl ENCODE 13.5 +50.1 50060 36.2 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 PPM1D RPS6KB1 NDUFB8P2 SMG8 LOC101927755 DHX40 TUBD1 VMP1 PTRH2 MIR21
GH17F059751 1.7 FANTOM5 Ensembl ENCODE 11.6 +131.5 131461 20.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 RPS6KB1 NDUFB8P2 LOC101927755 MIR21 RNU6-450P TUBD1 PPM1D SMG8 CA4 DHX40
GH17F059722 1.2 Ensembl ENCODE 11.8 +168.0 168031 5.0 HDGF ELF3 ARID4B YBX1 BMI1 RFX5 ZNF121 RCOR1 CREM MIXL1 LOC101927755 APPBP2 RPS6KB1 TUBD1 RNU6-450P RNFT1 DHX40 GC17M059723 PTRH2
GH17F060037 1.2 Ensembl ENCODE 11.2 -144.5 -144456 0.8 SIN3A ARID4B DMAP1 ZNF48 ZNF2 ZNF143 KLF7 DEK MIER2 TSHZ1 TUBD1 RPS6KB1 HEATR6 GC17P060035 MIR4737
GH17F059705 1.2 ENCODE 10.6 +185.1 185073 5.2 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SKA2 LOC101927755 LOC100996660 RPS6KB1 TUBD1 RNU6-450P TRIM37 DHX40 PTRH2 GC17M059723
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TUBD1 on UCSC Golden Path with GeneCards custom track

Promoters for TUBD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001537101 -155 2601 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for TUBD1 Gene

Chromosome:
17
Start:
59,859,479 bp from pter
End:
59,892,945 bp from pter
Size:
33,467 bases
Orientation:
Minus strand

Genomic View for TUBD1 Gene

Genes around TUBD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBD1 Gene

Proteins for TUBD1 Gene

  • Protein details for TUBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJT1-TBD_HUMAN
    Recommended name:
    Tubulin delta chain
    Protein Accession:
    Q9UJT1
    Secondary Accessions:
    • B4DPT8
    • B4DW01
    • D3DU02
    • E9PCA7
    • E9PCQ8
    • Q5KU36
    • Q9BWG9
    • Q9H7Z8

    Protein attributes for TUBD1 Gene

    Size:
    453 amino acids
    Molecular mass:
    51034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TUBD1 Gene

neXtProt entry for TUBD1 Gene

Post-translational modifications for TUBD1 Gene

  • Ubiquitination at Lys 47 and Lys 79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBD1 Gene

Domains & Families for TUBD1 Gene

Gene Families for TUBD1 Gene

Suggested Antigen Peptide Sequences for TUBD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJT1

UniProtKB/Swiss-Prot:

TBD_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBD1: view

Function for TUBD1 Gene

Molecular function for TUBD1 Gene

UniProtKB/Swiss-Prot Function:
In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Gene Ontology (GO) - Molecular Function for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBD1: view
genes like me logo Genes that share phenotypes with TUBD1: view

Animal Model Products

miRNA for TUBD1 Gene

miRTarBase miRNAs that target TUBD1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBD1 Gene

Localization for TUBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Nucleus. Note=Associated with centrioles. Both cytoplasmic and nuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUBD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005814 centriole IEA,TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Pathways & Interactions for TUBD1 Gene

genes like me logo Genes that share pathways with TUBD1: view

SIGNOR curated interactions for TUBD1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA --
GO:0007275 multicellular organism development IEA --
GO:0007283 spermatogenesis IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Drugs & Compounds for TUBD1 Gene

(4) Drugs for TUBD1 Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vinblastine Approved Pharma Target, adduct 413
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 111
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBD1 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolastatin 10 trifluoroacetate
MMAE
474645-27-7

(5) Tocris Compounds for TUBD1 Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Docetaxel Microtubule stabilizer 114977-28-5
Dolastatin 10 trifluoroacetate Tubulin polymerization inhibitor
MMAE Potent dolastatin 10 analog; antitumor 474645-27-7
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBD1: view

Transcripts for TUBD1 Gene

Unigene Clusters for TUBD1 Gene

Tubulin, delta 1:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - -

Relevant External Links for TUBD1 Gene

GeneLoc Exon Structure for
TUBD1
ECgene alternative splicing isoforms for
TUBD1

Expression for TUBD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TUBD1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TUBD1 Gene:

TUBD1

SOURCE GeneReport for Unigene cluster for TUBD1 Gene:

Hs.463638
genes like me logo Genes that share expression patterns with TUBD1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TUBD1 Gene

Orthologs for TUBD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBD1 34 35
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia TUBD1 34 35
  • 91.02 (n)
cow
(Bos Taurus)
Mammalia TUBD1 34 35
  • 90.14 (n)
mouse
(Mus musculus)
Mammalia Tubd1 34 16 35
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Tubd1 34
  • 82.63 (n)
oppossum
(Monodelphis domestica)
Mammalia TUBD1 35
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBD1 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TUBD1 34 35
  • 73.88 (n)
lizard
(Anolis carolinensis)
Reptilia TUBD1 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubd1 34
  • 72.21 (n)
Str.12654 34
African clawed frog
(Xenopus laevis)
Amphibia tubd1-A-prov 34
zebrafish
(Danio rerio)
Actinopterygii tubd1 34 35
  • 62.78 (n)
worm
(Caenorhabditis elegans)
Secernentea tbg-1 35
  • 20 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 35
  • 21 (a)
OneToMany
Species where no ortholog for TUBD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBD1 Gene

ENSEMBL:
Gene Tree for TUBD1 (if available)
TreeFam:
Gene Tree for TUBD1 (if available)

Paralogs for TUBD1 Gene

Paralogs for TUBD1 Gene

(5) SIMAP similar genes for TUBD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TUBD1: view

Variants for TUBD1 Gene

Sequence variations from dbSNP and Humsavar for TUBD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10679203 -- 59,875,094(+) TTTTT(-/T)GGGAT intron-variant
rs111244297 -- 59,890,049(+) CTCAG(-/GAGGCT)GAGAC intron-variant
rs111275832 -- 59,884,279(+) AAAAA(A/T)TTTTG intron-variant
rs111282327 -- 59,889,907(+) GGAGG(C/T)TACAG intron-variant
rs111516992 -- 59,878,560(+) GCTCA(A/C)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBD1 Gene

Variant ID Type Subtype PubMed ID
nsv1116228 CNV deletion 24896259
esv3640914 CNV gain 21293372
esv3554613 CNV deletion 23714750
esv2716085 CNV deletion 23290073

Variation tolerance for TUBD1 Gene

Residual Variation Intolerance Score: 32.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.32; 95.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBD1 Gene

Human Gene Mutation Database (HGMD)
TUBD1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBD1 Gene

Disorders for TUBD1 Gene

Relevant External Links for TUBD1

Genetic Association Database (GAD)
TUBD1
Human Genome Epidemiology (HuGE) Navigator
TUBD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBD1

No disorders were found for TUBD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBD1 Gene

Publications for TUBD1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P. … Stearns T. (Nat. Cell Biol. 2000) 2 3 4 22 64
  2. Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis. (PMID: 15081367) Kato A. … Todokoro K. (Dev. Biol. 2004) 3 4 22 64
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for TUBD1 Gene

Sources for TUBD1 Gene

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