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Aliases for TUBD1 Gene

Aliases for TUBD1 Gene

  • Tubulin, Delta 1 2 3
  • TUBD 3 4 6
  • Delta-Tubulin 3 4
  • Tubulin Delta Chain 3

External Ids for TUBD1 Gene

Previous GeneCards Identifiers for TUBD1 Gene

  • GC17M057786
  • GC17M060386
  • GC17M058278
  • GC17M058412
  • GC17M055291
  • GC17M057936
  • GC17M053309

Summaries for TUBD1 Gene

GeneCards Summary for TUBD1 Gene

TUBD1 (Tubulin, Delta 1) is a Protein Coding gene. Among its related pathways are ERK Signaling and PAK Pathway. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBG2.

UniProtKB/Swiss-Prot for TUBD1 Gene

  • In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Tocris Summary for TUBD1 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBD1 Gene

Genomics for TUBD1 Gene

Regulatory Elements for TUBD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUBD1 Gene

59,859,479 bp from pter
59,892,945 bp from pter
33,467 bases
Minus strand

Genomic View for TUBD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBD1 Gene

Proteins for TUBD1 Gene

  • Protein details for TUBD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin delta chain
    Protein Accession:
    Secondary Accessions:
    • B4DPT8
    • B4DW01
    • D3DU02
    • E9PCA7
    • E9PCQ8
    • Q5KU36
    • Q9BWG9
    • Q9H7Z8

    Protein attributes for TUBD1 Gene

    453 amino acids
    Molecular mass:
    51034 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TUBD1 Gene

neXtProt entry for TUBD1 Gene

Proteomics data for TUBD1 Gene at MOPED

Post-translational modifications for TUBD1 Gene

  • Ubiquitination at Lys47 and Lys79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBD1 Gene

Domains for TUBD1 Gene

Gene Families for TUBD1 Gene

Protein Domains for TUBD1 Gene

Suggested Antigen Peptide Sequences for TUBD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tubulin family.
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBD1: view

Function for TUBD1 Gene

Molecular function for TUBD1 Gene

UniProtKB/Swiss-Prot Function:
In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head.

Gene Ontology (GO) - Molecular Function for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBD1: view

miRNA for TUBD1 Gene

miRTarBase miRNAs that target TUBD1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBD1 Gene

Localization for TUBD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBD1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm. Nucleus. Note=Associated with centrioles. Both cytoplasmic and nuclear.

Subcellular locations from

Jensen Localization Image for TUBD1 Gene COMPARTMENTS Subcellular localization image for TUBD1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
golgi apparatus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005814 centriole IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Pathways for TUBD1 Gene

genes like me logo Genes that share pathways with TUBD1: view

Gene Ontology (GO) - Biological Process for TUBD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007017 microtubule-based process IEA --
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TUBD1: view

Compounds for TUBD1 Gene

(1) Drugbank Compounds for TUBD1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • (2alpha,2'BETA,3beta,4alpha,5beta)-vincaleukoblastine
865-21-4 241903 Target adduct approved

(5) Tocris Compounds for TUBD1 Gene

Compound Action Cas Number
ABT 751 Inhibitor of microtubule polymerization; antimitotic and antitumor [141430-65-1]
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Harmine Potent and selective Dyrk1A inhibitor [442-51-3]
Vinblastine sulfate Disrupts microtubules [143-67-9]
genes like me logo Genes that share compounds with TUBD1: view

Transcripts for TUBD1 Gene

Unigene Clusters for TUBD1 Gene

Tubulin, delta 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBD1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - - -
SP10: - - - - - - - - - - -
SP11: - - - - -
SP12: - - - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - - - -

Relevant External Links for TUBD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBD1 Gene

mRNA expression in normal human tissues for TUBD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBD1 Gene

SOURCE GeneReport for Unigene cluster for TUBD1 Gene Hs.463638

genes like me logo Genes that share expressions with TUBD1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for TUBD1 Gene

Orthologs for TUBD1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TUBD1 35
  • 90.14 (n)
  • 89.62 (a)
TUBD1 36
  • 90 (a)
(Canis familiaris)
Mammalia TUBD1 35
  • 91.02 (n)
  • 89.62 (a)
TUBD1 36
  • 90 (a)
(Mus musculus)
Mammalia Tubd1 35
  • 84.33 (n)
  • 85.65 (a)
Tubd1 16
Tubd1 36
  • 80 (a)
(Pan troglodytes)
Mammalia TUBD1 35
  • 99.78 (n)
  • 99.56 (a)
TUBD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tubd1 35
  • 82.63 (n)
  • 84.55 (a)
(Monodelphis domestica)
Mammalia TUBD1 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia TUBD1 36
  • 78 (a)
(Gallus gallus)
Aves TUBD1 35
  • 73.88 (n)
  • 75.06 (a)
TUBD1 36
  • 75 (a)
(Anolis carolinensis)
Reptilia TUBD1 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12654 35
tubd1 35
  • 72.21 (n)
  • 70.51 (a)
African clawed frog
(Xenopus laevis)
Amphibia tubd1-A-prov 35
(Danio rerio)
Actinopterygii tubd1 35
  • 62.78 (n)
  • 60.76 (a)
tubd1 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea tbg-1 36
  • 20 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB4 36
  • 21 (a)
Species with no ortholog for TUBD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBD1 Gene

Gene Tree for TUBD1 (if available)
Gene Tree for TUBD1 (if available)

Paralogs for TUBD1 Gene

Paralogs for TUBD1 Gene

(5) SIMAP similar genes for TUBD1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TUBD1: view

Variants for TUBD1 Gene

Sequence variations from dbSNP and Humsavar for TUBD1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1292041 -- 59,860,680(-) GAACC(C/T)GGGAG intron-variant
rs1292045 -- 59,869,851(-) CTGTC(A/G)TGTGT intron-variant
rs1292046 -- 59,868,818(-) cgctc(C/T)gtcgc intron-variant
rs1292047 -- 59,877,805(-) AGTGT(A/G)CAAGT intron-variant
rs1292048 -- 59,877,710(-) ACCTC(C/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBD1 Gene

Variant ID Type Subtype PubMed ID
esv2716085 CNV Deletion 23290073

Relevant External Links for TUBD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBD1 Gene

Disorders for TUBD1 Gene

(1) University of Copenhagen DISEASES for TUBD1 Gene

Relevant External Links for TUBD1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TUBD1: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for TUBD1 Gene

Publications for TUBD1 Gene

  1. Delta-tubulin and epsilon-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function. (PMID: 10620804) Chang P. … Stearns T. (Nat. Cell Biol. 2000) 2 3 4 23
  2. Delta-tubulin is a component of intercellular bridges and both the early and mature perinuclear rings during spermatogenesis. (PMID: 15081367) Kato A. … Todokoro K. (Dev. Biol. 2004) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 48

Products for TUBD1 Gene

Sources for TUBD1 Gene

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