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TUBB8 Gene

protein-coding   GIFtS: 47
GCID: GC10M000093

Tubulin, Beta 8 Class VIII

  See TUBB8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Beta 8 Class VIII1 2
Class VIII Beta-Tubulin1 2
bA631M21.22
HSA10p15 Beta-Tubulin 4Q2
Tubulin Beta-8 Chain2

External Ids:    HGNC: 207731   Entrez Gene: 3476882   Ensembl: ENSG000001738767   UniProtKB: Q3ZCM73   

Export aliases for TUBB8 gene to outside databases

Previous GC identifers: GC10M000082 GC10M000037


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TUBB8 Gene:
TUBB8 (tubulin, beta 8 class VIII) is a protein-coding gene. Diseases associated with TUBB8 include brain cancer. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is LOC260334.

UniProtKB/Swiss-Prot: TBB8_HUMAN, Q3ZCM7
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBB8 gene promoter:
         HOXA9B   HOXA9   TBP   SRF   Tal-1   p53   SRF (504 AA)   E47   ZID   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TUBB8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.3   Ensembl cytogenetic band:  10p15.3   HGNC cytogenetic band: 10p15.3

TUBB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBB8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M000093:  view genomic region     (about GC identifiers)

Start:
92,828 bp from pter      End:
120,103 bp from pter
Size:
27,276 bases      Orientation:
minus strand

1 alternative location:
Chr10-,NW_003571043 36,888-39,238     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBB8_HUMAN, Q3ZCM7 (See protein sequence)
Recommended Name: Tubulin beta-8 chain  
Size: 444 amino acids; 49776 Da
Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer
diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form
protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule
plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and specialized cells
Sequence caution: Sequence=CAI16221.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5SQX9 Q8WZ78

Explore the universe of human proteins at neXtProt for TUBB8: NX_Q3ZCM7

Explore proteomics data for TUBB8 at MOPED

Post-translational modifications: 

  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
  • Ubiquitination2 at Lys122, Lys154, Lys252
  • Modification sites at PhosphoSitePlus

  • See TUBB8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_817124.1  
    ENSEMBL proteins: 
     ENSP00000311042   ENSP00000371071   ENSP00000403895  

    TUBB8 Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TUBB8 

    TUBB8 Antibody Products:

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    Abcam antibodies for TUBB8
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    ThermoFisher Antibody for TUBB8
    LSBio Antibodies in human, mouse, rat for TUBB8

    TUBB8 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TUBB8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 8):
     IPR002453 Beta_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry Q3ZCM7

    ProtoNet protein and cluster: Q3ZCM7

    1 Blocks protein domain: IPB002453 Beta tubulin

    UniProtKB/Swiss-Prot: TBB8_HUMAN, Q3ZCM7
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBB8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBB8_HUMAN, Q3ZCM7
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with TUBB8           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBB8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBB8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBB8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUBB8

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    Predesigned siRNA for gene silencing in human, mouse, rat TUBB8

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBB8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBB8_HUMAN, Q3ZCM7: Cytoplasm, cytoskeleton (By similarity)

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005886plasma membrane ----
    GO:0015630microtubule cytoskeleton ----
    GO:0043234protein complex ----

    Find genes that share ontologies with TUBB8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBB8 About    
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Pathogenic Escherichia coli infection0.43
    2Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    wtCFTR and deltaF508 traffic Membrane expression norm and CF 0.38
    3Parkin-Ubiquitin Proteasomal System pathway
    Parkin-Ubiquitin Proteasomal System pathway0.89
    4Signaling in Gap Junctions
    Gap junction0.31
    5Phagosome
    Phagosome


    Find genes that share SuperPaths with TUBB8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for TUBB8 (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBB8
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection


    3 Kegg Pathways  (Kegg details for TUBB8):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Array including TUBB8: 
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TUBB8

    3 Interacting proteins for TUBB8 (Q3ZCM72, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K1Q132332, 3MINT-48325 I2D: score=2 
    MMEP084733I2D: score=2 
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process ----
    GO:0007017microtubule-based process IEA--
    GO:0008150biological_process ND--
    GO:0051258protein polymerization IEA--

    Find genes that share ontologies with TUBB8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TUBB8 (TBB8)

    1 HMDB Compound for TUBB8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUBB8 gene (2 alternative transcripts): 
    NM_001164154.1  NM_177987.2  

    Unigene Cluster for TUBB8:

    Tubulin, beta 8 class VIII
    Hs.532659  [show with all ESTs]
    Unigene Representative Sequence: NM_177987
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309812 ENST00000332708 ENST00000413237 ENST00000482075 ENST00000447903(uc001ifi.2)

    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TUBB8
    Clone
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    GenScript: all cDNA clones in your preferred vector: TUBB8 (NM_177987)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBB8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBB8
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TUBB8
      QuantiTect SYBR Green Assays in human, mouse, rat TUBB8
      QuantiFast Probe-based Assays in human, mouse, rat TUBB8

    Additional mRNA sequence: 

    BC101270.2 BC101271.1 

    1 DOTS entry:

    DT.102840564 

    17 AceView cDNA sequences:

    CR592383 CR592105 CR614889 CR605516 CR599052 CR601851 CR603249 CR626121 
    CR590375 CR621858 CR592639 CR612709 CR606225 CR600137 CR603378 CR591556 
    NM_177987 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBB8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TUBB8 Expression
    About this image

    TUBB8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBB8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532659
        Pathway & Disease-focused RT2 Profiler PCR Array including TUBB8: 
              Gap Junctions in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TUBB8
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    QuantiFast Probe-based Assays in human, mouse, rat TUBB8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBB8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TUBB8 gene from 7 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia TUBB81 tubulin, beta 8 class VIII 98.2(n)
    99.1(a)
      735320  XM_001135050.3  XP_001135050.1 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    89(a)
    many ↔ many
    2(66383182-66388095)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    88(a)
    many ↔ many
    GL343247.1(1045759-1055254)
    zebrafish
    (Danio rerio)
    Actinopterygii TUBB2A6
    tubulin, beta 2A class IIa
    87(a)
    1 → many
    2(1812385-1822105) ENSDARG00000039522
    fruit fly
    (Drosophila melanogaster)
    Insecta betaTub85D6
    beta-Tubulin at 85D
    87(a)
    1 → many
    3R(5234105-5236004)
    worm
    (Caenorhabditis elegans)
    Secernentea tbb-46
    mec-76
    (see all 5)
    Protein MEC-7 (mec-7) mRNA, complete cds
    (see all 5)
    87(a)
    87(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    X(9434452-9436893) WBGene00006538
    X(7774856-7776682) WBGene00003171
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB26
    Beta-tubulin; associates with alpha-tubulin (Tub1p...
    70(a)
    1 → many
    VI(56336-57709) YFL037W


    ENSEMBL Gene Tree for TUBB8 (if available)
    TreeFam Gene Tree for TUBB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBB8 gene
    LOC2603342  TUBB8P72  TUBB2  TUBB4B2  TUBB4A2  TUBB2B2  TUBB32  TUBE12  
    TUBB62  TUBB2A2  ENSG000002589472  TUBB12  
    Selected SIMAP similar genes for TUBB8 using alignment to 4 protein entries:     TBB8_HUMAN (see all proteins) (see all similar genes):
    DKFZp566F223    XTP3TPATP1    TUBB2C    TUBB2B    TUBB4B    TUBB4Q
    TUBB2A    TUBB    TUBB6    TUBB1    TUBB3    TUBB4A
    LOC402300    TUBA1    TUBA1A    MGC16703    TUBA8    TUBA4A

    Find genes that share paralogs with TUBB8           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TUBB8 (see all 9)
    PGOHUM00000251097 PGOHUM00000256869 PGOHUM00000244573 PGOHUM00000245232 PGOHUM00000256887


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBB8 (see all 242)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1999367421,2
    C--92350(+) CCAGAC/TATCCC 1 -- ds50010--------
    rs1995290011,2
    C,F--92981(+) TTTACC/TTAGAA 1 -- ut311Minor allele frequency- T:0.02EU 479
    rs2007809241,2
    --92990(+) AAAAG-/GAGAGTT 1 -- ut310--------
    rs3751162221,2
    C--93135(+) TCGCCC/TGTGTA 2 T syn10--------
    rs1478800411,2
    C--93257(+) CCCCCG/AGGGTG 2 /R /W mis11Minor allele frequency- A:0.00EU 1151
    rs48806081,2,,4
    H--93299(+) GGGGAG/ACCAGT 2 /L /F mis1 ese35Minor allele frequency- A:0.00NS EA NA 408
    rs97941001,2
    A--93315(+) AAGTAA/GCTGCT 2 S syn1 ese30--------
    rs1418260091,2
    F--93387(+) AAAATG/AGCAGC 2 /A syn11Minor allele frequency- A:0.00NA 2752
    rs1998260481,2
    F--93394(+) CAGCCG/ACCGTT 2 /A /V mis11Minor allele frequency- A:0.00EU 879
    rs413045771,2
    C,F--93425(+) GTCACA/GGGCAG 2 R C mis11Minor allele frequency- G:0.00EU 1017

    HapMap Linkage Disequilibrium report for TUBB8 (92828 - 120103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TUBB8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv8592CNV Gain18304495
    nsv894693CNV Gain21882294
    esv24948CNV Gain19812545
    dgv209e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBB8
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBB8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TUBB8:    
    About MalaCards
    brain cancer


    Find genes that share disorders with TUBB8           About GenesLikeMe


    Export disorders for TUBB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBB8 gene, integrated from 10 sources (see all 29):
    (articles sorted by number of sources associating them with TUBB8)
        Utopia: connect your pdf to the dynamic
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    1. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes. (PubMed id 11731935)1, 2 van Geel M.... de Jong P.J. (Am. J. Hum. Genet. 2002)
    2. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    3. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    4. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. PEX14 is required for microtubule-based peroxisome motility in human cells. (PubMed id 21525035)1 Bharti P....Erdmann R. (J. Cell. Sci. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347688 HGNC: 20773 AceView: TUBB8-pending Ensembl:ENSG00000173876 euGenes: HUgn347688
    ECgene: TUBB8 Kegg: 347688 H-InvDB: TUBB8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TUBB8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TUBB8 gene:
    Search GeneIP for patents involving TUBB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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