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Aliases for TUBB8 Gene

Aliases for TUBB8 Gene

  • Tubulin, Beta 8 Class VIII 2 3
  • Class VIII Beta-Tubulin 2 3
  • HSA10p15 Beta-Tubulin 4Q 3
  • Tubulin Beta-8 Chain 3
  • BA631M21.2 3

External Ids for TUBB8 Gene

Previous GeneCards Identifiers for TUBB8 Gene

  • GC10M000082
  • GC10M000037
  • GC10M000093

Summaries for TUBB8 Gene

GeneCards Summary for TUBB8 Gene

TUBB8 (Tubulin, Beta 8 Class VIII) is a Protein Coding gene. Diseases associated with TUBB8 include brain cancer. Among its related pathways are EphB-EphrinB Signaling and Development Slit-Robo signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot for TUBB8 Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBB8 Gene

Genomics for TUBB8 Gene

Regulatory Elements for TUBB8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUBB8 Gene

Start:
46,888 bp from pter
End:
50,113 bp from pter
Size:
3,226 bases
Orientation:
Minus strand

Genomic View for TUBB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBB8 Gene

Proteins for TUBB8 Gene

  • Protein details for TUBB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCM7-TBB8_HUMAN
    Recommended name:
    Tubulin beta-8 chain
    Protein Accession:
    Q3ZCM7
    Secondary Accessions:
    • Q5SQX9
    • Q8WZ78

    Protein attributes for TUBB8 Gene

    Size:
    444 amino acids
    Molecular mass:
    49776 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells
    SequenceCaution:
    • Sequence=CAI16221.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TUBB8 Gene

Proteomics data for TUBB8 Gene at MOPED

Post-translational modifications for TUBB8 Gene

  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Ubiquitination at Lys122, Lys154, and Lys252
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBB8 Gene

No data available for DME Specific Peptides for TUBB8 Gene

Domains for TUBB8 Gene

Gene Families for TUBB8 Gene

HGNC:
  • TUB :Tubulins

Suggested Antigen Peptide Sequences for TUBB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3ZCM7

UniProtKB/Swiss-Prot:

TBB8_HUMAN :
  • Q3ZCM7
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBB8: view

Function for TUBB8 Gene

Molecular function for TUBB8 Gene

UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Gene Ontology (GO) - Molecular Function for TUBB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBB8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBB8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TUBB8 Gene

Localization for TUBB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBB8 Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for TUBB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0043234 protein complex --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TUBB8: view

No data available for Subcellular locations from COMPARTMENTS for TUBB8 Gene

Pathways for TUBB8 Gene

genes like me logo Genes that share pathways with TUBB8: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Gap Junctions in human,mouse,rat

Interacting Proteins for TUBB8 Gene

Selected Interacting proteins: Q3ZCM7-TBB8_HUMAN for TUBB8 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for TUBB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007017 microtubule-based process IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0051258 protein polymerization IEA --
genes like me logo Genes that share ontologies with TUBB8: view

Compounds for TUBB8 Gene

(1) HMDB Compounds for TUBB8 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with TUBB8: view

Transcripts for TUBB8 Gene

mRNA/cDNA for TUBB8 Gene

Unigene Clusters for TUBB8 Gene

Tubulin, beta 8 class VIII:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBB8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TUBB8
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBB8 Gene

No ASD Table

Relevant External Links for TUBB8 Gene

GeneLoc Exon Structure for
TUBB8
ECgene alternative splicing isoforms for
TUBB8

Expression for TUBB8 Gene

mRNA expression in normal human tissues for TUBB8 Gene

mRNA differential expression in normal tissues according to GTEx for TUBB8 Gene

This gene is overexpressed in Testis (8.3) and Thyroid (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TUBB8 Gene

SOURCE GeneReport for Unigene cluster for TUBB8 Gene Hs.532659

genes like me logo Genes that share expressions with TUBB8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TUBB8 Gene

Orthologs for TUBB8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TUBB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBB8 35
  • 98.2 (n)
  • 99.1 (a)
Species with no ortholog for TUBB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TUBB8 Gene

ENSEMBL:
Gene Tree for TUBB8 (if available)
TreeFam:
Gene Tree for TUBB8 (if available)

Paralogs for TUBB8 Gene

genes like me logo Genes that share paralogs with TUBB8: view

No data available for Paralogs for TUBB8 Gene

Variants for TUBB8 Gene

Sequence variations from dbSNP and Humsavar for TUBB8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4266997 -- 50,494(+) GGCTG(C/T)GGCAT upstream-variant-2KB
rs4320883 -- 49,413(+) CTGTG(A/G)ATCCC upstream-variant-2KB
rs4431953 -- 48,005(+) TGCAG(A/G)CAGTC reference, synonymous-codon
rs4468273 -- 50,529(+) GGTCA(A/G)TCTCT upstream-variant-2KB
rs4567378 -- 50,655(+) CACCC(A/C)TTCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TUBB8 Gene

Variant ID Type Subtype PubMed ID
dgv209e1 CNV Complex 17122850
esv24948 CNV Gain 19812545
nsv894693 CNV Gain 21882294
nsv8592 CNV Gain 18304495

Relevant External Links for TUBB8 Gene

HapMap Linkage Disequilibrium report
TUBB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBB8 Gene

Disorders for TUBB8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TUBB8 Gene including...

Search for TUBB8 Gene in MalaCards »
genes like me logo Genes that share disorders with TUBB8: view

No data available for UniProtKB/Swiss-Prot for TUBB8 Gene

Publications for TUBB8 Gene

  1. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes. (PMID: 11731935) van Geel M. … de Jong P.J. (Am. J. Hum. Genet. 2002) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. (PMID: 12486001) Chen D. … Zhou Q. (EMBO J. 2002) 3
  4. Large-scale analysis of the human ubiquitin-related proteome. (PMID: 16196087) Matsumoto M. … Nakayama K.I. (Proteomics 2005) 3
  5. Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expression. (PMID: 16526095) Coiras M. … AlcamA- J. (Proteomics 2006) 3

Products for TUBB8 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Gap Junctions in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TUBB8
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TUBB8
    • Block miRNA regulation of TUBB8 using miScript Target Protectors

    Sources for TUBB8 Gene

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