Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TUBB8 Gene

Aliases for TUBB8 Gene

  • Tubulin Beta 8 Class VIII 2 3 5
  • Tubulin, Beta 8 Class VIII 2
  • HSA10p15 Beta-Tubulin 4Q 3
  • Class VIII Beta-Tubulin 2
  • BA631M21.2 3
  • OOMD2 3
  • OOMD 3

External Ids for TUBB8 Gene

Previous GeneCards Identifiers for TUBB8 Gene

  • GC10M000082
  • GC10M000037
  • GC10M000093

Summaries for TUBB8 Gene

Entrez Gene Summary for TUBB8 Gene

  • The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]

GeneCards Summary for TUBB8 Gene

TUBB8 (Tubulin Beta 8 Class VIII) is a Protein Coding gene. Diseases associated with TUBB8 include oocyte maturation defect. Among its related pathways are Development Slit-Robo signaling and Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB2B.

UniProtKB/Swiss-Prot for TUBB8 Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBB8 Gene

Genomics for TUBB8 Gene

Regulatory Elements for TUBB8 Gene

Genomic Location for TUBB8 Gene

Chromosome:
10
Start:
46,638 bp from pter
End:
76,455 bp from pter
Size:
29,818 bases
Orientation:
Minus strand

Genomic View for TUBB8 Gene

Genes around TUBB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBB8 Gene

Proteins for TUBB8 Gene

  • Protein details for TUBB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3ZCM7-TBB8_HUMAN
    Recommended name:
    Tubulin beta-8 chain
    Protein Accession:
    Q3ZCM7
    Secondary Accessions:
    • Q5SQX9
    • Q8WZ78

    Protein attributes for TUBB8 Gene

    Size:
    444 amino acids
    Molecular mass:
    49776 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
    SequenceCaution:
    • Sequence=CAI16221.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TUBB8 Gene

Proteomics data for TUBB8 Gene at MOPED

Post-translational modifications for TUBB8 Gene

  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBB8 Gene

Antibody Products

No data available for DME Specific Peptides for TUBB8 Gene

Domains & Families for TUBB8 Gene

Gene Families for TUBB8 Gene

Suggested Antigen Peptide Sequences for TUBB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3ZCM7

UniProtKB/Swiss-Prot:

TBB8_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBB8: view

Function for TUBB8 Gene

Molecular function for TUBB8 Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Gene Ontology (GO) - Molecular Function for TUBB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBB8: view
genes like me logo Genes that share phenotypes with TUBB8: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBB8 Gene

Localization for TUBB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBB8 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBB8 Gene COMPARTMENTS Subcellular localization image for TUBB8 gene
Compartment Confidence
extracellular 5
cytoskeleton 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TUBB8: view

Pathways & Interactions for TUBB8 Gene

genes like me logo Genes that share pathways with TUBB8: view

Interacting Proteins for TUBB8 Gene

Selected Interacting proteins: Q3ZCM7-TBB8_HUMAN for TUBB8 Gene via I2D MINT

Gene Ontology (GO) - Biological Process for TUBB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TUBB8: view

No data available for SIGNOR curated interactions for TUBB8 Gene

Drugs & Compounds for TUBB8 Gene

(1) Drugs for TUBB8 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with TUBB8: view

Transcripts for TUBB8 Gene

Unigene Clusters for TUBB8 Gene

Tubulin, beta 8 class VIII:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBB8 Gene

No ASD Table

Relevant External Links for TUBB8 Gene

GeneLoc Exon Structure for
TUBB8
ECgene alternative splicing isoforms for
TUBB8

Expression for TUBB8 Gene

mRNA expression in normal human tissues for TUBB8 Gene

mRNA differential expression in normal tissues according to GTEx for TUBB8 Gene

This gene is overexpressed in Testis (x8.3) and Thyroid (x4.2).

Protein differential expression in normal tissues from HIPED for TUBB8 Gene

This gene is overexpressed in Retina (8.8), Bone marrow stromal cell (7.6), and Amniocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TUBB8 Gene



SOURCE GeneReport for Unigene cluster for TUBB8 Gene Hs.532659

genes like me logo Genes that share expression patterns with TUBB8: view

Protein tissue co-expression partners for TUBB8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TUBB8 Gene

Orthologs for TUBB8 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TUBB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBB8 35
  • 98.2 (n)
  • 99.1 (a)
Species with no ortholog for TUBB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TUBB8 Gene

ENSEMBL:
Gene Tree for TUBB8 (if available)
TreeFam:
Gene Tree for TUBB8 (if available)

Paralogs for TUBB8 Gene

Paralogs for TUBB8 Gene

genes like me logo Genes that share paralogs with TUBB8: view

Variants for TUBB8 Gene

Sequence variations from dbSNP and Humsavar for TUBB8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_039240 -
rs1816273 -- 54,264(-) GTGGG(C/T)GCTAA intron-variant
rs2379066 -- 70,969(+) TACAC(C/T)GATTA intron-variant
rs2379067 -- 71,014(+) CCATC(A/T)AAAAA intron-variant
rs2434915 -- 57,415(-) TTATG(A/G)AGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBB8 Gene

Variant ID Type Subtype PubMed ID
dgv209e1 CNV Complex 17122850
esv24948 CNV Gain 19812545
nsv894693 CNV Gain 21882294
nsv8592 CNV Gain 18304495

Variation tolerance for TUBB8 Gene

Residual Variation Intolerance Score: 93.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBB8 Gene

HapMap Linkage Disequilibrium report
TUBB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBB8 Gene

Disorders for TUBB8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TUBB8 Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
oocyte maturation defect
  • oocyte maturation defect 1
- elite association - COSMIC cancer census association via MalaCards
Search TUBB8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TUBB8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBB8
genes like me logo Genes that share disorders with TUBB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBB8 Gene

Publications for TUBB8 Gene

  1. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes. (PMID: 11731935) van Geel M. … de Jong P.J. (Am. J. Hum. Genet. 2002) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  4. Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. (PMID: 24337577) Andresen C.A. … Flores-Morales A. (J. Biol. Chem. 2014) 3
  5. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3

Products for TUBB8 Gene

Sources for TUBB8 Gene

Back to Top

Content