Aliases for TUBB8 Gene
External Ids for TUBB8 Gene
Previous GeneCards Identifiers for TUBB8 Gene
The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]
GeneCards Summary for TUBB8 Gene
TUBB8 (Tubulin Beta 8 Class VIII) is a Protein Coding gene. Diseases associated with TUBB8 include Oocyte Maturation Defect. Among its related pathways are Regulation of CFTR activity (norm and CF) and Phagosome. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB2B.
UniProtKB/Swiss-Prot for TUBB8 Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).