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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUBB6 Gene

protein-coding GIFtS: 57
GCID: GC18P012299

tubulin, beta 6 class V

(Previous names: tubulin, beta 6 )

Explore 5 diseases affiliated with
TUBB6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubulin, Beta 6 Class V¹ ²		TUBB-5²
HsT1601¹ ²		Class V Beta-Tubulin²
MGC4083¹		Tubulin Beta MGC4083²
Tubulin, Beta 6¹		Tubulin Beta-6 Chain²

External Ids:	HGNC: 20776¹	Entrez Gene: 84617²	Ensembl: ENSG00000176014⁷	UniProtKB: Q9BUF5³

Export aliases for TUBB6 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TBB6_HUMAN, Q9BUF5

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)

summary for TUBB6:

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in

turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits

are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine

cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires

motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end

of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the

spindle fibers for separating chromosomes during mitosis.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TUBB6 gene promoter:
Egr-3 Spz1 Elk-1 Tal-1beta Evi-1 Ik-2 FOXJ2 (long isoform) FOXJ2 ITF-2 ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUBB6 promoter sequence

Search SABiosciences Chromatin IP Primers for TUBB6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBB6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.21 Ensembl cytogenetic band: 18p11.21 HGNC cytogenetic band: 18p11.21

TUBB6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBB6 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P012299: view genomic region (about GC identifiers)

Start:	12,307,668 bp from pter	End:	12,344,319 bp from pter
Size:	36,652 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TBB6_HUMAN, Q9BUF5 (See protein sequence)

Recommended Name: Tubulin beta-6 chain

Size: 446 amino acids; 49857 Da

Subunit: Dimer of alpha and beta chains (By similarity)

Subcellular location: Cytoplasm, cytoskeleton (By similarity)

Secondary accessions: B3KM76 Q9HA42

Explore the universe of human proteins at neXtProt for TUBB6: NX_Q9BUF5

Post-translational modifications:

Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate

residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated

due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into

axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the

mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation

levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but

they regulate the assembly and dynamics of axonemal microtubules (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BUF5

TUBB6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_115914.1

ENSEMBL proteins:

ENSP00000465891 ENSP00000318697 ENSP00000468777 ENSP00000465040 ENSP00000468179

ENSP00000468820 ENSP00000467348 ENSP00000467969 ENSP00000465386 ENSP00000466849

ENSP00000468571 ENSP00000465448

Reactome Protein details: Q9BUF5
Human Recombinant Protein Products for TUBB6:

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	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005874	microtubule	IDA	--
GO:0005886	plasma membrane	IDA	--
GO:0015630	microtubule cytoskeleton	IDA	--

TUBB6 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TUBB6 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR002453 Beta_tubulin

IPR000217 Tubulin

IPR003008 Tubulin_FtsZ_GTPase

IPR023123 Tubulin_C

IPR008280 Tub_FtsZ_C

Graphical View of Domain Structure for InterPro Entry Q9BUF5

ProtoNet protein and cluster: Q9BUF5

1 Blocks protein family: IPB002453 Beta tubulin

UniProtKB/Swiss-Prot: TBB6_HUMAN, Q9BUF5

Domain: The highly acidic C-terminal region may bind cations such as calcium

Similarity: Belongs to the tubulin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TBB6_HUMAN, Q9BUF5

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005198	structural molecule activity	IEA	--
GO:0005525	GTP binding	IEA	--

TUBB6 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for TUBB6:

Increased cell number in G2M,

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TUBB6

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBB6

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Recruitment of mitotic centrosome proteins and complexes

	Recruitment of mitotic centrosome proteins and complexes	1.00			G2/M Transition	0.83
	Centrosome maturation	1.00			Mitotic G2-G2/M phases	0.81

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Recycling pathway of L1	0.15

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	1.00			Post-chaperonin tubulin folding pathway	0.67
	Transport of connexons to the plasma membrane	0.93			Recruitment of NuMA to mitotic centrosomes	0.50

Formation of tubulin folding intermediates by CCT/TriC

	Formation of tubulin folding intermediates by CCT/TriC	1.00			Prefoldin mediated transfer of substrate to CCT/TriC	0.70
	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for TUBB6 (see all 9)

	Cytoskeleton remodeling Neurofilaments
	Cytoskeleton remodeling Slit-Robo signaling
	Cytoplasmic microtubules
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cytoskeleton remodeling Keratin filaments

5/10 GeneGo (Thomson Reuters) Pathways for TUBB6 (see all 10)

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Cell cycle Spindle assembly and chromosome separation
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Keratin filaments

2 BioSystems Pathways for TUBB6

	Parkin-Ubiquitin Proteasomal System pathway
	Pathogenic Escherichia coli infection

5/41 Reactome Pathways for TUBB6 (see all 41)

	L1CAM interactions
	Mitotic Prometaphase
	Membrane Trafficking
	Protein folding
	Recruitment of mitotic centrosome proteins and complexes

3 Kegg Pathways (Kegg details for TUBB6):

	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection

TUBB6 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TUBB6

STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

5/52 Interacting proteins for TUBB6 (Q9BUF5^{2, 3} ENSP00000318697⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 52)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K1	Q13233²^,³	MINT-48321 I2D: score=2
MAP3K3	Q99759²^,³	MINT-48451 I2D: score=2
NFKB2	Q00653²^,³	MINT-48737 I2D: score=2
TNFRSF1A	P19438²^,³	MINT-49335 I2D: score=2
TRAF6	Q9Y4K3²^,³	MINT-49593 I2D: score=2

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006457	protein folding	TAS	--
GO:0007018	microtubule-based movement	IEA	--
GO:0044267	cellular protein metabolic process	TAS	--
GO:0051084	'de novo' posttranslational protein folding	TAS	--
GO:0051258	protein polymerization	IEA	--

TUBB6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TUBB6 available from Tocris Bioscience About this table

Compound	Action	CAS #
XRP44X	Ras-Net pathway inhibitor	[729605-21-4]
Taxol	Promotes assembly and inhibits disassembly of microtubules	[33069-62-4]
Vincristine sulfate	Disrupts microtubules	[2068-78-2]
Vinblastine sulfate	Disrupts microtubules	[143-67-9]
Nocodazole	Microtubule inhibitor	[31430-18-9]

2 HMDB Compounds for TUBB6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about TUBB6 / TBB6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUBB6 gene:

NM_032525.1

Unigene Clusters for TUBB6:

Tubulin, beta 6 class V

Hs.193491 [show with all ESTs], Hs.744066 [show with all ESTs]

Unigene Representative Sequences: AK298196, AK092677

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000590693 ENST00000317702(uc010dld.3 uc002kqw.3 uc002kqy.3)

ENST00000590103 ENST00000591909 ENST00000590388 ENST00000586653 ENST00000586810

ENST00000417736(uc002kqv.3) ENST00000587204 ENST00000592683 ENST00000590967

ENST00000591208 ENST00000591463 ENST00000586691

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		1 QIAGEN miScript miRNA Assays for microRNA that regulate TUBB6:
		hsa-miR-217
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Additional cDNA sequence:

AK001295.1 AK022340.1 AK092677.1 AK098440.1 AK311364.1 BC002654.1 BC111374.1

24/32 DOTS entries (see all 32):

DT.100769752 DT.455606 DT.121082704 DT.91768617 DT.100059430 DT.100058891 DT.100653523 DT.100820138

DT.121082685 DT.91810619 DT.100032341 DT.100820143 DT.100653516 DT.121082745 DT.121082751 DT.91768615

DT.95195583 DT.70100087 DT.121082789 DT.100708063 DT.100820137 DT.100059325 DT.100653525 DT.40123946

24/464 AceView cDNA sequences (see all 464):

CR594370 CR593665 BE384071 BQ028938 H71157 BM916277 CR595733 AW135528

BG768834 BE409066 BU149943 CA417792 BM761047 AA082096 BE276859 BU957759

BC002654 BM476704 BM556599 CD701728 BE562844 BG698171 CD514731 BM476328

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TUBB6 (see all 7) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4	^	5a	·	5b	^	6a	·	6b	·	6c	·	6d
SP1:							-								-		-
SP2:							-						-		-		-
SP3:							-						-
SP4:							-						-
SP5:							-				-		-		-		-

ECgene alternative splicing isoforms for TUBB6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUBB6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

TUBB6 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Basal Cells

Lung

Pancreas

Dorsal Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Ventral Pancreatic Bud

Immature Beta Progenitor Cells

Pancreas

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Secondary follicles (Primary Cell)

Ovary, Reproductive System

See TUBB6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUBB6

SOURCE GeneReport for Unigene clusters: Hs.193491 Hs.744066

UniProtKB/Swiss-Prot: TBB6_HUMAN, Q9BUF5

Tissue specificity: Ubiquitous. Maximal expression in breast and lung, where it represents around 10% of all

beta-tubulins. Largely decreased expression in most cancerous tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including TUBB6:

Gap Junctions in human mouse rat

Cardiotoxicity in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TUBB6 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TUBB6¹	tubulin, beta 6 class V	82.32(n) 97.98(a)		421037 NM_001031012.1 NP_001026183.1
zebrafish (Danio rerio)	Actinopterygii	tubb6⁶	tubulin, beta 6 class V	94(a)	1 ↔ 1	24(3130620-3137133)
fruit fly (Drosophila melanogaster)	Insecta	betaTub60D⁶ CG32396⁶	--	85(a) 50(a)	1 ↔ many possible ortholog	2R(20193405-20200626) 3L(6523829-6525529)
worm (Caenorhabditis elegans)	Secernentea	tbb-4⁶ tbb-6⁶	Tubulin, Beta family member (tbb-6)	89(a) 56(a)	1 ↔ many possible ortholog	X(9434393-9436834) V(12261785-12263349)

ENSEMBL Gene Tree for TUBB6 (if available)
TreeFam Gene Tree for TUBB6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TUBB6 gene

TUBB² TUBB8² TUBB4A² TUBB4B² TUBB2B² TUBB3² ENSG00000173213² TUBB2A²

TUBE1² TUBB1² ENSG00000258947²

18/31 SIMAP similar genes for TUBB6 using alignment to 14 protein entries: TBB6_HUMAN (see all proteins) (see all similar genes):

XTP3TPATP1 DKFZp566F223 TUBB2B TUBB3 TUBB2C TUBB4A

TUBB4B TUBB2A TUBB4Q TUBB TUBB8 TUBB1

LOC402300 TUBA1B TUBA1 TUBA1A TUBA4A TUBA1C

TUBB6 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TUBB6
PGOHUM00000237437 PGOHUM00000243972

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76448124^1,2	C	--	12306298(+)	`AACTGT/ACCCCA`	1	--	int¹		4		NA WA EA	360
rs141238259^1,2		--	12306326(+)	`GGTTCA/CTTCTG`	1	--	int¹		0	--	--	--	--
rs188289259^1,2		--	12306333(+)	`TCTGCC/GGGGAA`	1	--	int¹		0	--	--	--	--
rs180925272^1,2		--	12306371(+)	`TCTGAG/TGAGAG`	1	--	int¹		0	--	--	--	--
rs144951953^1,2		--	12306400(+)	`GCAGGC/GGGAAG`	1	--	int¹		0	--	--	--	--
rs185329621^1,2		--	12306431(+)	`CTCTTC/TGAGCA`	1	--	int¹		0	--	--	--	--
rs191216587^1,2		--	12306494(+)	`CGCAGA/GGCGCA`	1	--	int¹		0	--	--	--	--
rs183470479^1,2		--	12306501(+)	`CGCACA/TGCGAG`	1	--	int¹		0	--	--	--	--
rs114870171^1,2		--	12306550(+)	`CAAATC/TCAAGT`	1	--	int¹		1		WA	118
rs186959166^1,2		--	12306817(+)	`CGGCAA/GGATGG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TUBB6 (12307668 - 12344319 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TUBB6
1 CNV: 4052

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TUBB6 for disorders About GeneDecksing

5 diseases for TUBB6: About MalaCards

anonychia congenita lung carcinoma carcinoma malaria

neuronitis

1 disease from the University of Copenhagen DISEASES database for TUBB6:

Nail disease

Export disorders for TUBB6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TUBB6 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with TUBB6)

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Tumoral and tissue-specific expression of the major h uman beta-tubulin isotypes. (PubMed id 20191564)^{1, 2} Leandro-GarcA-a L.J....RodrA-guez-Antona C. (2010)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Gender influences the class III and V b-tubulin abilit y to predict poor outcome in colorectal cancer. (PubMed id 22438565)¹ Mariani M....Ferlini C. (2012)
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. (PubMed id 23042605)¹ Mosbech A.... Mailand N. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)¹ Haines D.S....Deshaies R.J. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84617	HGNC: 20776	AceView: MGC4083	Ensembl:ENSG00000176014	euGenes: HUgn84617
ECgene: TUBB6	Kegg: 84617	H-InvDB: TUBB6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TUBB6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUBB6 gene
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Patent Information for TUBB6 gene:
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GeneCards and IP:
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tubulin, beta 6 class V

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TUBB6 Gene

tubulin, beta 6 class V

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