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Aliases for TUBB6 Gene

Aliases for TUBB6 Gene

  • Tubulin, Beta 6 Class V 2 3
  • Tubulin Beta MGC4083 2 3
  • Class V Beta-Tubulin 2 3
  • Tubulin Beta Class V 3 4
  • Tubulin Beta-6 Chain 3
  • Tubulin, Beta 6 2
  • HsT1601 3
  • TUBB-5 3

External Ids for TUBB6 Gene

Summaries for TUBB6 Gene

GeneCards Summary for TUBB6 Gene

TUBB6 (Tubulin, Beta 6 Class V) is a Protein Coding gene. Diseases associated with TUBB6 include nail disease. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and EphB-EphrinB Signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB3.

UniProtKB/Swiss-Prot for TUBB6 Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Tocris Summary for TUBB6 Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBB6 Gene

Genomics for TUBB6 Gene

Regulatory Elements for TUBB6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUBB6 Gene

Start:
12,307,669 bp from pter
End:
12,344,320 bp from pter
Size:
36,652 bases
Orientation:
Plus strand

Genomic View for TUBB6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBB6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBB6 Gene

Proteins for TUBB6 Gene

  • Protein details for TUBB6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUF5-TBB6_HUMAN
    Recommended name:
    Tubulin beta-6 chain
    Protein Accession:
    Q9BUF5
    Secondary Accessions:
    • B3KM76
    • Q9HA42

    Protein attributes for TUBB6 Gene

    Size:
    446 amino acids
    Molecular mass:
    49857 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells

neXtProt entry for TUBB6 Gene

Proteomics data for TUBB6 Gene at MOPED

Post-translational modifications for TUBB6 Gene

  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Ubiquitination at Lys58, Lys252, and Lys362
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TUBB6 Gene

Domains for TUBB6 Gene

Gene Families for TUBB6 Gene

HGNC:
  • TUB :Tubulins

Graphical View of Domain Structure for InterPro Entry

Q9BUF5

UniProtKB/Swiss-Prot:

TBB6_HUMAN :
  • Q9BUF5
Domain:
  • The highly acidic C-terminal region may bind cations such as calcium
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBB6: view

Function for TUBB6 Gene

Molecular function for TUBB6 Gene

UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Gene Ontology (GO) - Molecular Function for TUBB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBB6: view

Phenotypes for TUBB6 Gene

GenomeRNAi human phenotypes for TUBB6:
genes like me logo Genes that share phenotypes with TUBB6: view

Animal Model Products

miRNA for TUBB6 Gene

miRTarBase miRNAs that target TUBB6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBB6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBB6 Gene

Localization for TUBB6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBB6 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBB6 Gene COMPARTMENTS Subcellular localization image for TUBB6 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 4
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TUBB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IDA 21525035
GO:0043234 protein complex --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TUBB6: view

Pathways for TUBB6 Gene

genes like me logo Genes that share pathways with TUBB6: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TUBB6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006457 protein folding TAS --
GO:0007017 microtubule-based process IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
genes like me logo Genes that share ontologies with TUBB6: view

Compounds for TUBB6 Gene

(5) Tocris Compounds for TUBB6 Gene

Compound Action Cas Number
ABT 751 Inhibitor of microtubule polymerization; antimitotic and antitumor [141430-65-1]
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Harmine Potent and selective Dyrk1A inhibitor [442-51-3]
Vinblastine sulfate Disrupts microtubules [143-67-9]

(2) HMDB Compounds for TUBB6 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with TUBB6: view

Transcripts for TUBB6 Gene

Unigene Clusters for TUBB6 Gene

Tubulin, beta 6 class V:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBB6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBB6 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - - -
SP6: - - - - -
SP7: - - -

Relevant External Links for TUBB6 Gene

GeneLoc Exon Structure for
TUBB6
ECgene alternative splicing isoforms for
TUBB6

Expression for TUBB6 Gene

mRNA expression in normal human tissues for TUBB6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBB6 Gene

SOURCE GeneReport for Unigene cluster for TUBB6 Gene Hs.193491

mRNA Expression by UniProt/SwissProt for TUBB6 Gene

Q9BUF5-TBB6_HUMAN
Tissue specificity: Ubiquitous. Maximal expression in breast and lung, where it represents around 10% of all beta-tubulins. Largely decreased expression in most cancerous tissues.
genes like me logo Genes that share expressions with TUBB6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TUBB6 Gene

Orthologs for TUBB6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TUBB6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBB6 35
  • 99.33 (n)
  • 100 (a)
TUBB6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBB6 35
  • 91.63 (n)
  • 98.14 (a)
TUBB6 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBB6 35
  • 93.26 (n)
  • 98.2 (a)
TUBB6 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubb6 35
  • 90.3 (n)
  • 97.92 (a)
Tubb6 16
Tubb6 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBB6 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TUBB6 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubb6 35
  • 91.38 (n)
  • 98.15 (a)
chicken
(Gallus gallus)
Aves TUBB6 35
  • 82.29 (n)
  • 98.38 (a)
TUBB6 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tubb6 35
  • 78.14 (n)
  • 97 (a)
zebrafish
(Danio rerio)
Actinopterygii tubb6 36
  • 94 (a)
OneToOne
Species with no ortholog for TUBB6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TUBB6 Gene

ENSEMBL:
Gene Tree for TUBB6 (if available)
TreeFam:
Gene Tree for TUBB6 (if available)

Paralogs for TUBB6 Gene

Pseudogenes.org Pseudogenes for TUBB6 Gene

genes like me logo Genes that share paralogs with TUBB6: view

Variants for TUBB6 Gene

Sequence variations from dbSNP and Humsavar for TUBB6 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs8611 -- 12,326,131(-) TTCCG(A/G)CTATC utr-variant-3-prime
rs1139387 -- 12,326,341(+) ATCAC(A/C)CCATG utr-variant-3-prime
rs1139388 -- 12,326,388(+) GGGCC(A/C)CAAAA utr-variant-3-prime
rs1139389 -- 12,326,402(+) ACTTC(A/C)CCTTC utr-variant-3-prime
rs3206872 -- 12,326,296(+) AGACT(A/T)AAAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TUBB6 Gene

Variant ID Type Subtype PubMed ID
nsv909400 CNV Loss 21882294
nsv909401 CNV Gain 21882294
dgv3387n71 CNV Loss 21882294
dgv1012e1 CNV Complex 17122850

Relevant External Links for TUBB6 Gene

HapMap Linkage Disequilibrium report
TUBB6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBB6 Gene

Disorders for TUBB6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TUBB6 Gene including...

Search for TUBB6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TUBB6 Gene

genes like me logo Genes that share disorders with TUBB6: view

No data available for UniProtKB/Swiss-Prot for TUBB6 Gene

Publications for TUBB6 Gene

  1. Tumoral and tissue-specific expression of the major human beta- tubulin isotypes. (PMID: 20191564) Leandro-Garcia L.J. … Rodriguez-Antona C. (Cytoskeleton 2010) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. (PMID: 15331610) Campbell G.R. … Loret E.P. (J. Biol. Chem. 2004) 3

Products for TUBB6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TUBB6
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBB6
  • Block miRNA regulation of TUBB6 using miScript Target Protectors

Sources for TUBB6 Gene

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