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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUBB4B Gene

protein-coding GIFtS: 54
GCID: GC09P140136

tubulin, beta 4B class IVb

(Previous names: tubulin, beta 2C )
(Previous symbol: TUBB2C)

Explore 13 diseases affiliated with
TUBB4B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubulin, Beta 4B Class IVb¹ ²		TUBB2²
TUBB2C¹ ² ³		Class IVb Beta Tubulin²
Beta2¹ ²		Class IVb Beta-Tubulin²
Tubulin, Beta 2C¹ ²		Tubulin Beta-4B Chain²
Tubulin Beta-2 Chain² ³		Tubulin, Beta, 2²
Tubulin Beta-2C Chain² ³

External Ids:	HGNC: 20771¹	Entrez Gene: 10383²	Ensembl: ENSG00000188229⁷	OMIM: 602660⁵	UniProtKB: P68371³

Export aliases for TUBB4B gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBB4B:

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in

turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits

are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine

cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires

motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end

of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the

spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBB4B (TUBB2C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_024000.16

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TUBB4B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUBB4B promoter sequence

Search SABiosciences Chromatin IP Primers for TUBB4B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBB4B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34.3

TUBB4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBB4B gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P140136: view genomic region (about GC identifiers)

Start:	140,135,665 bp from pter	End:	140,138,159 bp from pter
Size:	2,495 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371 (See protein sequence)

Recommended Name: Tubulin beta-4B chain

Size: 445 amino acids; 49831 Da

Subunit: Dimer of alpha and beta chains

Subcellular location: Cytoplasm, cytoskeleton

Secondary accessions: A2BFA2 P05217

Explore the universe of human proteins at neXtProt for TUBB4B: NX_P68371

Post-translational modifications:

Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate

residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated

due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into

axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the

mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation

levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but

they regulate the assembly and dynamics of axonemal microtubules (Probable)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P68371

TUBB4B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006079.1

ENSEMBL proteins:

ENSP00000341289

Reactome Protein details: P68371
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IDA	--
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	TAS	16130169
GO:0005874	microtubule	IDA	--

TUBB4B for ontologies About GeneDecksing

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Assay Products for TUBB4B:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TUBB4B for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR002453 Beta_tubulin

IPR000217 Tubulin

IPR003008 Tubulin_FtsZ_GTPase

IPR023123 Tubulin_C

IPR008280 Tub_FtsZ_C

Graphical View of Domain Structure for InterPro Entry P68371

ProtoNet protein and cluster: P68371

1 Blocks protein family: IPB002453 Beta tubulin

UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371

Domain: The highly acidic C-terminal region may bind cations such as calcium

Similarity: Belongs to the tubulin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

miRNA Products:		OriGene 3'-UTR Clone: TUBB4B Browse MicroRNA Expression Plasmids
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Gene Editing
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBB4B

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005198	structural molecule activity	IEA	--
GO:0005200	structural constituent of cytoskeleton	--	--
GO:0005525	GTP binding	IEA	--
GO:0042288	MHC class I protein binding	TAS	11120798

TUBB4B for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for TUBB4B:

Increased G2M DNA content

Increased number of mitotic ce

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Recruitment of mitotic centrosome proteins and complexes

Recruitment of mitotic centrosome proteins and complexes	1.00	Mitotic G2-G2/M phases	0.81
Centrosome maturation	1.00	Loss of proteins required for interphase microtubule organizationÂ from the centrosome	0.78
G2/M Transition	0.83	Loss of Nlp from mitotic centrosomes	0.78

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Recycling pathway of L1	0.15

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	1.00			Post-chaperonin tubulin folding pathway	0.67
	Transport of connexons to the plasma membrane	0.93			Recruitment of NuMA to mitotic centrosomes	0.50

Formation of tubulin folding intermediates by CCT/TriC

	Formation of tubulin folding intermediates by CCT/TriC	1.00			Prefoldin mediated transfer of substrate to CCT/TriC	0.70
	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for TUBB4B (see all 9)

	Cytoskeleton remodeling Neurofilaments
	Cytoskeleton remodeling Slit-Robo signaling
	Cytoplasmic microtubules
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cytoskeleton remodeling Keratin filaments

5/10 GeneGo (Thomson Reuters) Pathways for TUBB4B (see all 10)

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Cell cycle Spindle assembly and chromosome separation
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Keratin filaments

2 BioSystems Pathways for TUBB4B

	Pathogenic Escherichia coli infection
	Parkin-Ubiquitin Proteasomal System pathway

5/43 Reactome Pathways for TUBB4B (see all 43)

	L1CAM interactions
	Mitotic Prometaphase
	Membrane Trafficking
	Protein folding
	Recruitment of mitotic centrosome proteins and complexes

3 Kegg Pathways (Kegg details for TUBB4B):

	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection

TUBB4B for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TUBB4B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/919 Interacting proteins for TUBB4B (P68371^{2, 3} ENSP00000341289⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 919)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK9	P50750²^,³	MINT-7945693 MINT-7947479 I2D: score=1
NSF	P46459²^,³	MINT-7945693 MINT-7947479 I2D: score=1
UBA5	Q9GZZ9²^,³	MINT-7945693 MINT-7947479 I2D: score=1
YWHAE	P62258²^,³	MINT-7947479 MINT-8395092 I2D: score=1
DLEU1	O43261²^,³	MINT-63117 I2D: score=2

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006457	protein folding	TAS	--
GO:0006928	cellular component movement	TAS	16130169
GO:0007017	microtubule-based process	--	--

TUBB4B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TUBB4B available from Tocris Bioscience About this table

Compound	Action	CAS #
XRP44X	Ras-Net pathway inhibitor	[729605-21-4]
Taxol	Promotes assembly and inhibits disassembly of microtubules	[33069-62-4]
Vincristine sulfate	Disrupts microtubules	[2068-78-2]
Vinblastine sulfate	Disrupts microtubules	[143-67-9]
Nocodazole	Microtubule inhibitor	[31430-18-9]

Search CenterWatch for drugs/clinical trials and news about TUBB4B / TBB4B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUBB4B gene:

NM_006088.5

Unigene Cluster for TUBB4B:

Tubulin, beta 4B class IVb

Hs.433615 [show with all ESTs]

Unigene Representative Sequence: BX648521

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000340384(uc004cmg.1 uc004cmh.1)

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Additional cDNA sequence:

AF064849.1 AK000560.1 AK021414.1 AK026167.1 AK026594.1 AK026609.1 AK098686.1 AK298087.1

AY167990.1 BC001911.1 BC002783.1 BC002885.2 BC004188.2 BC007889.2 BC008006.1 BC012835.2

BC019359.1 BC019829.1 BC024038.1 BC029529.1 BC039175.1 BC071889.1 BX648521.1 EF036499.1

24/63 DOTS entries (see all 63):

DT.87002174 DT.91779055 DT.100059988 DT.453639 DT.91779019 DT.95361033 DT.121210590 DT.121210416

DT.91901378 DT.92009164 DT.121210394 DT.121210378 DT.100893257 DT.121210446 DT.95361040 DT.40119917

DT.100892960 DT.100893156 DT.100892961 DT.121210372 DT.121307030 DT.100059989 DT.100893076 DT.121210387

24/118 AceView cDNA sequences (see all 118):

AL546281 AA009732 AA102026 CF527820 AA454557 BM663319 BU681903 AA456449

AA009448 AW167408 AW247945 BG288185 AL532993 AA102027 AW250930 AW674448

AW249118 BM690508 AW731829 AW248382 AW673878 AA988110 CD743244 CB140762

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TUBB4B (see all 8) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	·	5d
SP1:											-		-		-		-
SP2:											-		-		-
SP3:															-		-
SP4:							-		-		-		-		-		-		-		-
SP5:

ECgene alternative splicing isoforms for TUBB4B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUBB4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTACAGAC

About this image
See TUBB4B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUBB4B

SOURCE GeneReport for Unigene cluster: Hs.433615

UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for TUBB4B

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBB4B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBB4B gene from 9/36 species (see all 36) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TUBB2C¹	tubulin, beta 2C	86.83(n) 100(a)		417255 NM_001080860.2 NP_001074329.2
lizard (Anolis carolinensis)	Reptilia	TUBB4B⁶	--	100(a)	1 ↔ 1	GL344097.1(50627-55227)
African clawed frog (Xenopus laevis)	Amphibia	L06232.1²	--	85.82(n)		L06232.1
zebrafish (Danio rerio)	Actinopterygii	tubb4b¹	tubulin, beta 4B class IVb	83.07(n) 98.88(a)		336681 NM_198809.2 NP_942104.2
fruit fly (Drosophila melanogaster)	Insecta	betaTub56D¹	beta-Tubulin at 56D	84.08(n) 96.62(a)		37238 NM_079071.2 NP_523795.2
worm (Caenorhabditis elegans)	Secernentea	tbb-4¹	Protein TBB-4	74.43(n) 94.34(a)		181170 NM_077184.3 NP_509585.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TUB2¹	Tub2p	66.29(n) 75.74(a)		850506 NP_116616.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TUB7¹	tubulin beta	72.62(n) 86.43(a)		817504 NM_128508.2 NP_180515.1
rice (Oryza sativa)	Liliopsida	Os03g0780600¹	hypothetical protein	76.77(n) 88.01(a)		4334309 NM_001057986.1 NP_001051451.1

ENSEMBL Gene Tree for TUBB4B (if available)
TreeFam Gene Tree for TUBB4B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TUBB4B gene

TUBB² TUBB8² TUBB4A² TUBB2B² TUBB3² ENSG00000173213² TUBB2A² TUBE1²

TUBB6² TUBB1² ENSG00000258947²

18/27 SIMAP similar genes for TUBB4B using alignment to 1 protein entry: TBB4B_HUMAN(see all similar genes):

TUBB2C TUBB4A XTP3TPATP1 TUBB2B TUBB2A DKFZp566F223

TUBB3 TUBB6 TUBB8 TUBB4Q TUBB TUBB1

TUBG1 TUBA1A TUBA1C TUBA2 TUBA3C TUBA3D

TUBB4B for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TUBB4B
PGOHUM00000246030 PGOHUM00000243825 PGOHUM00000236762

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9330200^1,2	C,H	--	109596964(+)	`GTGGAT/AGAGCA`	1	--	int¹		5		NS EA NA	408
rs113210630^1,2	C,F	--	109597081(+)	`GCCACC/G/TTTCAT`	1	--	int¹		2		CSA NA	4548
rs9722604^1,2	C,F,H,	--	140133719(+)	`AGATGC/TCCAGT`	1	--	us2k¹		15		NS EA NA	2218
rs191708477^1,2		--	140133787(+)	`TACAAA/TAATAC`	1	--	us2k¹		0	--	--	--	--
rs146866732^1,2		--	140133927(+)	`TAGCCA/GGGCGT`	1	--	us2k¹		0	--	--	--	--
rs112959179^1,2		--	140133934(+)	`GCGTGG/ATGGCG`	1	--	us2k¹		1		CSA	2
rs184250998^1,2		--	140134018(+)	`TGAGCC/TGAGAT`	1	--	us2k¹		0	--	--	--	--
rs189251979^1,2		--	140134120(+)	`TGTAGA/TTCCAG`	1	--	us2k¹		0	--	--	--	--
rs9802782^1,2	C,F,	--	140134148(+)	`GCAGGC/AGAATT`	1	--	us2k¹		2		NA EA	240
rs144450408^1,2		--	140134322(+)	`CGAGGA/CGGGCG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TUBB4B (140135665 - 140138159 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TUBB4B: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBB4B

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TUBB4B for disorders           About GeneDecksing

OMIM gene information: 602660    OMIM disorders: --

13 diseases for TUBB4B:    About MalaCards

oral squamous cell carcinoma squamous cell carcinoma intrahepatic cholangiocarcinoma cholangiocarcinoma

nasopharyngitis colorectal cancer prostate cancer myeloma

carcinoma prostatitis melanoma pancreatitis

malaria

Export disorders for TUBB4B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TUBB4B gene, integrated from 9 sources (see all 93):
(articles sorted by number of sources associating them with TUBB4B)

Utopia: connect your pdf to the dynamic
world of online information

Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype. (PubMed id 3999141)^{1, 2, 3} Lewis S.A.... Cowan N.J. (1985)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma. (PubMed id 18384219)^{1, 9} Chan C.M....Chan A.T. (2008)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. (PubMed id 23042605)¹ Mosbech A.... Mailand N. (2012)
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)¹ Haines D.S....Deshaies R.J. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)¹ Oshikawa K....Nakayama K.I. (2012)
Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)¹ Naji S....Gerace L. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10383	HGNC: 20771	AceView: TUBB2.1	Ensembl:ENSG00000188229	euGenes: HUgn10383
ECgene: TUBB4B	Kegg: 10383	H-InvDB: TUBB4B

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TUBB4B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUBB4B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TUBB4B gene:
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TUBB4B Gene

tubulin, beta 4B class IVb

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TUBB4B Gene

tubulin, beta 4B class IVb

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