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TUBB4B Gene

protein-coding   GIFtS: 59
GCID: GC09P140136

Tubulin, Beta 4B Class IVb

(Previous names: tubulin, beta 2C)
(Previous symbol: TUBB2C)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tubulin, Beta 4B Class IVb1 2     Beta22
TUBB2C1 2 3 5     TUBB22
Tubulin, Beta 2C1 2     Class IVb Beta Tubulin2
Class IVb Beta-Tubulin1 2     Tubulin Beta-4B Chain2
Tubulin Beta-2 Chain2 3     Tubulin, Beta, 22
Tubulin Beta-2C Chain2 3     

External Ids:    HGNC: 207711   Entrez Gene: 103832   Ensembl: ENSG000001882297   OMIM: 6026605   UniProtKB: P683713   
ORGUL members:         

Export aliases for TUBB4B gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TUBB4B Gene:
TUBB4B (tubulin, beta 4B class IVb) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and GTP binding. An important paralog of this gene is LOC260334.

UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBB4B Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBB4B (TUBB2C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TUBB4B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBB4B promoter sequence
   Search Chromatin IP Primers for TUBB4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBB4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34   Ensembl cytogenetic band:  9q34.3   HGNC cytogenetic band: 9q34.3

TUBB4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBB4B gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P140136:  view genomic region     (about GC identifiers)

Start:
140,135,665 bp from pter      End:
140,138,159 bp from pter
Size:
2,495 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371 (See protein sequence)
Recommended Name: Tubulin beta-4B chain  
Size: 445 amino acids; 49831 Da
Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer
diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form
protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule
plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and specialized cells
Secondary accessions: A2BFA2 P05217

Explore the universe of human proteins at neXtProt for TUBB4B: NX_P68371

Explore proteomics data for TUBB4B at MOPED

Post-translational modifications: 

  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
  • Ubiquitination2 at Lys58, Lys103, Lys216, Lys252, Lys297, Lys324, Lys336, Lys350, Lys362, Lys379
  • Modification sites at PhosphoSitePlus

  • See TUBB4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006079.1  
    ENSEMBL proteins: 
     ENSP00000341289  
    Reactome Protein details: P68371

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    antibodies-online proteins for TUBB4B (22 products) 

     
    antibodies-online peptides for TUBB4B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 8):
     IPR002453 Beta_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry P68371

    ProtoNet protein and cluster: P68371

    1 Blocks protein domain: IPB002453 Beta tubulin

    UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371
    Domain: The highly acidic C-terminal region may bind cations such as calcium
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBB4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBB4B_HUMAN, P68371
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA--
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005525GTP binding IEA--
    GO:0042288MHC class I protein binding TAS11120798
         
    Find genes that share ontologies with TUBB4B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TUBB4B:
     Increased G2M DNA content  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TUBB4B

    miRNA
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    miRTarBase miRNAs that target TUBB4B:
    hsa-mir-1226-3p (MIRT036534), hsa-mir-17-3p (MIRT050785), hsa-mir-30a-5p (MIRT007296), hsa-let-7e-5p (MIRT051633), hsa-mir-92a-3p (MIRT049307), hsa-mir-331-3p (MIRT043536), hsa-mir-16-5p (MIRT031472), hsa-mir-17-5p (MIRT050955), hsa-mir-25-3p (MIRT050330), hsa-mir-186-5p (MIRT044989), hsa-mir-128-3p (MIRT045881), hsa-mir-106b-5p (MIRT044273), hsa-mir-365a-3p (MIRT044022), hsa-mir-301a-3p (MIRT044225)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBB4B_HUMAN, P68371: Cytoplasm, cytoskeleton

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0005874microtubule IDA--

    Find genes that share ontologies with TUBB4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBB4B About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    4Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    5Protein folding
    Chaperonin-mediated protein folding0.91
    Post-chaperonin tubulin folding pathway0.00
    Protein folding0.91


    Find genes that share SuperPaths with TUBB4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBB4B (see all 9)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Signaling in Gap Junctions
    Epithelial Adherens Junctions

    Selected GeneGo (Thomson Reuters) Pathways for TUBB4B (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBB4B
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection


    Selected Reactome Pathways for TUBB4B (see all 17)
        Resolution of Sister Chromatid Cohesion
    Prefoldin mediated transfer of substrate to CCT/TriC
    Mitotic Prometaphase
    Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes


    3 Kegg Pathways  (Kegg details for TUBB4B):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBB4B
    Interactions:

        Search GeneGlobe Interaction Network for TUBB4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBB4B (P683712, 3 ENSP000003412894) via UniProtKB, MINT, STRING, and/or I2D (see all 990)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDK9P507502, 3MINT-7945693 MINT-7947479 I2D: score=1 
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    YWHAEP622582, 3MINT-7947479 MINT-8395092 I2D: score=1 
    DLEU1O432612, 3MINT-63117 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006184GTP catabolic process ----
    GO:0006457protein folding TAS--
    GO:0006928cellular component movement TAS16130169

    Find genes that share ontologies with TUBB4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Compounds for TUBB4B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUBB4B gene: 
    NM_006088.5  

    Unigene Cluster for TUBB4B:

    Tubulin, beta 4B class IVb
    Hs.433615  [show with all ESTs]
    Unigene Representative Sequence: BX648521
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340384(uc004cmg.1 uc004cmh.1) ENST00000604929
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    Additional mRNA sequence: 

    AF064849.1 AK000560.1 AK021414.1 AK026167.1 AK026594.1 AK026609.1 AK098686.1 AK298087.1 
    AY167990.1 BC001911.1 BC002783.1 BC002885.2 BC004188.2 BC007889.2 BC008006.1 BC012835.2 
    BC019359.1 BC019829.1 BC024038.1 BC029529.1 BC039175.1 BC071889.1 BX648521.1 EF036499.1 

    Selected DOTS entries (see all 63):

    DT.87002174  DT.91779055  DT.100059988  DT.453639  DT.91779019  DT.95361033  DT.121210590  DT.121210416 
    DT.91901378  DT.92009164  DT.121210394  DT.121210378  DT.100893257  DT.121210446  DT.95361040  DT.40119917 
    DT.100892960  DT.100893156  DT.100892961  DT.121210372  DT.100059989  DT.121307030  DT.100893076  DT.121210387 

    Selected AceView cDNA sequences (see all 118):

    AA009732 AA009448 BM663319 AL546281 AA454557 BU681903 AA456449 AA102026 
    CF527820 AW249118 AW674448 AL532993 AW250930 AA102027 BG288185 AW247945 
    AW167408 BM690508 AW731829 CA415674 CB140762 AA194755 AA194754 CD743244 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TUBB4B (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d
    SP1:                                -     -     -     -                                       
    SP2:                                -     -     -                                             
    SP3:                                            -     -                                       
    SP4:                    -     -     -     -     -     -     -     -                           
    SP5:                                                                                          


    ECgene alternative splicing isoforms for TUBB4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBB4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTACAGAC
    TUBB4B Expression
    About this image


    TUBB4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Cerebral Cortex
             Olfactory Bulb   
    TUBB4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBB4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433615

    UniProtKB/Swiss-Prot: TBB4B_HUMAN, P68371
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBB4B gene from Selected species (see all 27)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubb4b1 , 5 tubulin, beta 4B class IVB1, 5 90.11(n)1
    100(a)1
      2 (17.08 cM)5
    2276131  NM_146116.21  NP_666228.11 
     252221605 
    chicken
    (Gallus gallus)
    Aves TUBB2C1 tubulin, beta 2C 86.83(n)
    100(a)
      417255  NM_001080860.2  NP_001074329.2 
    lizard
    (Anolis carolinensis)
    Reptilia TUBB4B6
    tubulin, beta 4B class IVb
    100(a)
    1 ↔ 1
    GL344097.1(50627-55911)
    African clawed frog
    (Xenopus laevis)
    Amphibia L06232.12   -- 85.82(n)    L06232.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tubb4b1 tubulin, beta 4B class IVb 83.07(n)
    98.88(a)
      336681  NM_198809.2  NP_942104.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta betaTub56D1 beta-Tubulin at 56D 84.23(n)
    97.66(a)
      37238  NM_079071.2  NP_523795.2 
    worm
    (Caenorhabditis elegans)
    Secernentea tbb-41 tbb-4 74.55(n)
    95.78(a)
      181170  NM_077184.4  NP_509585.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB21 TUB2 66.59(n)
    77.05(a)
      850506   NP_116616.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TUB11 TUB1 71.66(n)
    86.42(a)
      843911  NM_106228.2  NP_177706.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07806001 Os03g0780600 76.97(n)
    88.76(a)
      4334309  NM_001057986.1  NP_001051451.1 


    ENSEMBL Gene Tree for TUBB4B (if available)
    TreeFam Gene Tree for TUBB4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBB4B gene
    LOC2603342  TUBB8P72  TUBB2  TUBB4A2  TUBB82  TUBB2B2  TUBB32  TUBE12  
    TUBB62  TUBB2A2  ENSG000002589472  TUBB12  
    Selected SIMAP similar genes for TUBB4B using alignment to 1 protein entry:     TBB4B_HUMAN(see all similar genes):
    TUBB2C    XTP3TPATP1    TUBB2B    TUBB2A    DKFZp566F223    TUBB3
    TUBB8    TUBB6    TUBB4Q    TUBB    TUBB1    TUBB4A
    TUBA1A    TUBG1    TUBA1C    TUBA2    TUBA3C    TUBA3D

    Find genes that share paralogs with TUBB4B           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for TUBB4B
    PGOHUM00000246030 PGOHUM00000243825 PGOHUM00000236762


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBB4B (see all 154)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs97226041,2
    C,F,H--140133719(+) AGATGC/TCCAGT 1 -- us2k115Minor allele frequency- T:0.13NS EA NA 2218
    rs1917084771,2
    --140133787(+) TACAAA/TAATAC 1 -- us2k10--------
    rs1468667321,2
    --140133927(+) TAGCCA/GGGCGT 1 -- us2k10--------
    rs1129591791,2
    C,F--140133934(+) GCGTGG/ATGGCG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1842509981,2
    --140134018(+) TGAGCC/TGAGAT 1 -- us2k10--------
    rs1892519791,2
    --140134120(+) TGTAGA/TTCCAG 1 -- us2k10--------
    rs98027821,2
    C,F--140134148(+) gcaggC/Agaatt 1 -- us2k12Minor allele frequency- A:0.18NA EA 240
    rs1444504081,2
    --140134322(+) CGAGGA/CGGGCG 1 -- us2k10--------
    rs1822446431,2
    --140134341(+) GAGGTC/TAGGAG 1 -- us2k10--------
    rs115247231,2
    C,F--140134479(+) TGGGGC/G/TGGGGC 1 -- us2k1 tfbs37NA WA CSA 16

    HapMap Linkage Disequilibrium report for TUBB4B (140135665 - 140138159 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TUBB4B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBB4B
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBB4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602660    OMIM disorders: --


    Find genes that share disorders with TUBB4B           About GenesLikeMe


    Export disorders for TUBB4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBB4B gene, integrated from 10 sources (see all 112):
    (articles sorted by number of sources associating them with TUBB4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype. (PubMed id 3999141)1, 2, 3 Lewis S.A.... Cowan N.J. (J. Mol. Biol. 1985)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma. (PubMed id 18384219)1, 9 Chan C.M....Chan A.T. (amp 2008)
    4. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    5. Autophagy negatively regulates cancer cell proliferation via selectively targeting VPRBP. (PubMed id 22963397)1 Wang B.S....Wang M.R. (Clin. Sci. 2013)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    8. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    9. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    10. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (PubMed id 23703321)1 New M....La Thangue N.B. (Cell Death Differ. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10383 HGNC: 20771 AceView: TUBB2.1 Ensembl:ENSG00000188229 euGenes: HUgn10383
    ECgene: TUBB4B Kegg: 10383 H-InvDB: TUBB4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TUBB4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TUBB4B gene:
    Search GeneIP for patents involving TUBB4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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