Aliases for TUBB4B Gene
External Ids for TUBB4B Gene
Previous Symbols for TUBB4B Gene
GeneCards Summary for TUBB4B Gene
TUBB4B (Tubulin, Beta 4B Class IVb) is a Protein Coding gene. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include GTP binding and unfolded protein binding. An important paralog of this gene is TUBB3.
UniProtKB/Swiss-Prot for TUBB4B Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.