Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TUBB2B Gene

protein-coding   GIFtS: 63
GCID: GC06M003224

Tubulin, Beta 2B Class IIb

(Previous names: tubulin, beta 2B)
  See TUBB2B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tubulin, Beta 2B Class IIb1 2     bA506K6.12
Class IIb Beta-Tubulin1 2     Class II Beta-Tubulin Isotype2
PMGYSA2 5     Tubulin Beta-2B Chain2
Tubulin, Beta 2B1     Tubulin, Beta Polypeptide Paralog2

External Ids:    HGNC: 308291   Entrez Gene: 3477332   Ensembl: ENSG000001372857   OMIM: 6128505   UniProtKB: Q9BVA13   

Export aliases for TUBB2B gene to outside databases

Previous GC identifers: GC06M003172 GC06M003173 GC06M003102


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TUBB2B Gene:
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of
microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric
polymicrogyria. (provided by RefSeq, Mar 2010)

GeneCards Summary for TUBB2B Gene:
TUBB2B (tubulin, beta 2B class IIb) is a protein-coding gene. Diseases associated with TUBB2B include polymicrogyria, symmetric or asymmetric, and polymicrogyria, asymmetric. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is LOC260334.

UniProtKB/Swiss-Prot: TBB2B_HUMAN, Q9BVA1
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in
neuronal migration

summary for TUBB2B Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBB2B gene promoter:
         C/EBPbeta   MyoD   Olf-1   HNF-3beta   Arnt   Gfi-1   IRF-2   Cart-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBB2B promoter sequence
   Search Chromatin IP Primers for TUBB2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBB2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25   Ensembl cytogenetic band:  6p25.2   HGNC cytogenetic band: 6p25.2

TUBB2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBB2B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M003224:  view genomic region     (about GC identifiers)

Start:
3,224,495 bp from pter      End:
3,231,964 bp from pter
Size:
7,470 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TBB2B_HUMAN, Q9BVA1 (See protein sequence)
Recommended Name: Tubulin beta-2B chain  
Size: 445 amino acids; 49953 Da
Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer
diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form
protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule
plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and specialized cells
Secondary accessions: A8K068

Explore the universe of human proteins at neXtProt for TUBB2B: NX_Q9BVA1

Explore proteomics data for TUBB2B at MOPED

Post-translational modifications: 

  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
  • Ubiquitination2 at Lys58, Lys103, Lys216, Lys252, Lys297, Lys324, Lys336, Lys350, Lys362, Lys379
  • Modification sites at PhosphoSitePlus

  • See TUBB2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_821080.1  
    ENSEMBL proteins: 
     ENSP00000259818  
    Reactome Protein details: Q9BVA1

    TUBB2B Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TUBB2B
    OriGene Protein Over-expression Lysate for TUBB2B
    OriGene MassSpec for TUBB2B
    OriGene Custom Protein Services for TUBB2B
    GenScript Custom Purified and Recombinant Proteins Services for TUBB2B
    Novus Biologicals TUBB2B Protein
    Novus Biologicals TUBB2B Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TUBB2B 

    TUBB2B Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TUBB2B
    OriGene Custom Antibody Services for TUBB2B
    Novus Biologicals TUBB2B Antibodies
    Abcam antibodies for TUBB2B (P68371, Q9BVA1, Q13885)
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for TUBB2B
    LSBio Antibodies in human, mouse, rat for TUBB2B

    TUBB2B Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TUBB2B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TUBB2B
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TUBB2B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 8):
     IPR002453 Beta_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry Q9BVA1

    ProtoNet protein and cluster: Q9BVA1

    1 Blocks protein domain: IPB002453 Beta tubulin

    UniProtKB/Swiss-Prot: TBB2B_HUMAN, Q9BVA1
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBB2B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBB2B_HUMAN, Q9BVA1
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in
    neuronal migration

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with TUBB2B           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TUBB2B:
     Decreased cilium length after   Increased 8N DNA content  Increased number of mitotic ce 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tubb2b):
     behavior/neurological  cellular  craniofacial  mortality/aging  nervous system 
     reproductive system  respiratory system 

    Find genes that share phenotypes with TUBB2B           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBB2B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBB2B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBB2B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUBB2B

    miRNA
    Products:
        
    miRTarBase miRNAs that target TUBB2B:
    hsa-mir-877-5p (MIRT037235), hsa-mir-1 (MIRT023769), hsa-mir-92a-3p (MIRT048981), hsa-mir-615-3p (MIRT040215), hsa-mir-124-3p (MIRT022690), hsa-mir-186-5p (MIRT045115)

    Block miRNA regulation of human, mouse, rat TUBB2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUBB2B (see all 14):
    hsa-miR-579 hsa-miR-16-2* hsa-miR-1197 hsa-miR-520d-5p hsa-miR-196a* hsa-miR-29a hsa-miR-29c hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidTUBB2B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TUBB2B
    Predesigned siRNA for gene silencing in human, mouse, rat TUBB2B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TUBB2B

    Clone
    Products:
         
    OriGene clones in human, mouse for TUBB2B (see all 6)
    OriGene ORF clones in mouse, rat for TUBB2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBB2B (NM_178012)
    Sino Biological Human cDNA Clone for TUBB2B
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBB2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBB2B

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TUBB2B
    ESI BIO PureStem Progenitor for TUBB2B: 
    PureStem ES-210, Ecto-ntu Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBB2B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TBB2B_HUMAN, Q9BVA1: Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane4
    cytosol3
    nucleus2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IDA--
    GO:0005886plasma membrane ----
    GO:0015630microtubule cytoskeleton ----
    GO:0043234protein complex ----

    Find genes that share ontologies with TUBB2B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TUBB2B About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    4Protein folding
    Chaperonin-mediated protein folding0.91
    Post-chaperonin tubulin folding pathway0.00
    Protein folding0.91
    5Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76


    Find genes that share SuperPaths with TUBB2B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for TUBB2B (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBB2B
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection


    Selected Reactome Pathways for TUBB2B (see all 13)
        Resolution of Sister Chromatid Cohesion
    Prefoldin mediated transfer of substrate to CCT/TriC
    Mitotic Prometaphase
    Translocation of GLUT4 to the plasma membrane
    Recruitment of NuMA to mitotic centrosomes


    3 Kegg Pathways  (Kegg details for TUBB2B):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Array including TUBB2B: 
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TUBB2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBB2B (Q9BVA11, 2, 3 ENSP000002598184) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253737 I2D: score=5 
    ENSG00000206406P678702, 3MINT-8253737 I2D: score=5 
    ENSG00000224398P678702, 3MINT-8253737 I2D: score=5 
    ENSG00000224774P678702, 3MINT-8253737 I2D: score=5 
    ENSG00000228875P678702, 3MINT-8253737 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IMP19465910
    GO:0006184GTP catabolic process ----
    GO:0006457protein folding TAS--
    GO:0007017microtubule-based process IEA--
    GO:0044267cellular protein metabolic process TAS--

    Find genes that share ontologies with TUBB2B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TUBB2B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 HMDB Compound for TUBB2B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    1 DrugBank Compound for TUBB2B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TUBB2B gene: 
    NM_178012.4  

    Unigene Cluster for TUBB2B:

    Tubulin, beta 2B class IIb
    Hs.300701  [show with all ESTs]
    Unigene Representative Sequence: NM_178012
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259818(uc003mvg.3) ENST00000473006
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TUBB2B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TUBB2B (see all 14):
    hsa-miR-579 hsa-miR-16-2* hsa-miR-1197 hsa-miR-520d-5p hsa-miR-196a* hsa-miR-29a hsa-miR-29c hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidTUBB2B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TUBB2B
    Predesigned siRNA for gene silencing in human, mouse, rat TUBB2B
    Clone
    Products:
         
    OriGene clones in human, mouse for TUBB2B (see all 6)
    OriGene ORF clones in mouse, rat for TUBB2B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBB2B (NM_178012)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBB2B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBB2B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TUBB2B
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBB2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBB2B
      QuantiTect SYBR Green Assays in human, mouse, rat TUBB2B
      QuantiFast Probe-based Assays in human, mouse, rat TUBB2B

    Additional mRNA sequence: 

    AF035316.1 AK289433.1 AK297568.1 AL050056.1 BC001352.2 BC063610.1 BC127872.1 BC127874.1 
    BT019930.1 CR456788.1 

    Selected DOTS entries (see all 76):

    DT.100893165  DT.100893069  DT.100893270  DT.95152292  DT.100893246  DT.100893200  DT.100892974  DT.100893128 
    DT.100893195  DT.121379966  DT.92067601  DT.100893216  DT.100893034  DT.100893275  DT.121380188  DT.121379977 
    DT.100769009  DT.97869229  DT.100893164  DT.100059854  DT.121379940  DT.95152294  DT.100893045  DT.100893166 

    Selected AceView cDNA sequences (see all 2209):

    CR608366 CR598348 CR613947 BX419233 CR614155 CR590622 CR619672 CR625236 
    CR609010 BQ065745 CR609227 BC063610 BU740829 BQ061169 CR625133 CR615252 
    CR616836 AL534428 CR619904 BU848950 BU845862 AL534065 CR618559 CR607116 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TUBB2B    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
    SP1:        -                                 
    SP2:                                          
    SP3:        -                                 


    ECgene alternative splicing isoforms for TUBB2B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TUBB2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTACTTTA
    TUBB2B Expression
    About this image


    TUBB2B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             hIPS1
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             pre Conventional Dendritic Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
    TUBB2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBB2B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.300701

    UniProtKB/Swiss-Prot: TBB2B_HUMAN, Q9BVA1
    Tissue specificity: High expression in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including TUBB2B: 
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUBB2B
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBB2B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBB2B
    QuantiTect SYBR Green Assays in human, mouse, rat TUBB2B
    QuantiFast Probe-based Assays in human, mouse, rat TUBB2B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBB2B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBB2B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubb2b1 , 5 tubulin, beta 2B class IIB1, 5 91.54(n)1
    100(a)1
      13 (14.04 cM)5
    737101  NM_023716.21  NP_076205.11 
     341270085 
    chicken
    (Gallus gallus)
    Aves TUBB2B1 tubulin, beta 2B class IIb 89.21(n)
    99.55(a)
      420883  NM_001004400.2  NP_001004400.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    98(a)
    100(a)
    many ↔ many
    many ↔ many
    GL343247.1(1045759-1055254)
    GL343247.1(1065224-1078450)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC756282 hypothetical protein MGC75628 82.34(n)    BC064166.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tubb22 tubulin, beta, 2 85.3(n)   336681  BC056533.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta betaTub85D1 beta-Tubulin at 85D 82.95(n)
    96.51(a)
      41124  NM_079566.4  NP_524290.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mec-71 mec-7 75.66(n)
    94.19(a)
      181036  NM_076912.3  NP_509313.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB26
    Beta-tubulin; associates with alpha-tubulin (Tub1p...
    72(a)
    1 → many
    VI(56336-57709) YFL037W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TUB21 TUB2 73.72(n)
    86.98(a)
      836390  NM_125664.3  NP_568959.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06613001 Os03g0661300 79.38(n)
    85.12(a)
      4333632  NM_001057360.1  NP_001050825.1 


    ENSEMBL Gene Tree for TUBB2B (if available)
    TreeFam Gene Tree for TUBB2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TUBB2B gene
    LOC2603342  TUBB8P72  TUBB2  TUBB4B2  TUBB4A2  TUBB82  TUBB32  TUBE12  
    TUBB62  TUBB2A2  ENSG000002589472  TUBB12  
    Selected SIMAP similar genes for TUBB2B using alignment to 2 protein entries:     TBB2B_HUMAN (see all proteins) (see all similar genes):
    DKFZp566F223    XTP3TPATP1    TUBB2A    TUBB4B    TUBB2C    TUBB3
    TUBB8    TUBB6    TUBB    TUBB4Q    TUBB4A    TUBB1
    TUBA1    TUBA1A    TUBA4A    TUBA1C    TUBA2    TUBA3C

    Find genes that share paralogs with TUBB2B           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TUBB2B (see all 8)
    PGOHUM00000242422 PGOHUM00000239404 PGOHUM00000239742 PGOHUM00000238121 PGOHUM00000243043


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TUBB2B (see all 129)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0633924
    Polymicrogyria, symmetric or asymmetric (PMGYSA)4--see VAR_0633922 L P mis40--------
    VAR_0633934
    Polymicrogyria, symmetric or asymmetric (PMGYSA)4--see VAR_0633932 F L mis40--------
    VAR_0633944
    Polymicrogyria, symmetric or asymmetric (PMGYSA)4--see VAR_0633942 T M mis40--------
    VAR_0633914
    Polymicrogyria, symmetric or asymmetric (PMGYSA)4--see VAR_0633912 I T mis40--------
    VAR_0633894
    Polymicrogyria, symmetric or asymmetric (PMGYSA)4--see VAR_0633892 S P mis40--------
    rs1445538171,2
    C,Funtested13155105(+) AACTCC/TCCTTG 2 G syn12Minor allele frequency- T:0.00NA EU 5871
    rs1488454811,2
    --3154162(+) TTAATA/GACCAT 1 -- ds50010--------
    rs744128221,2
    C,F--3154215(+) TGGACG/ACTACA 1 -- ds50011Minor allele frequency- A:0.04EA 120
    rs1151724161,2
    C,F--3154289(+) CAGAAT/CTGTGT 1 -- ds50011Minor allele frequency- C:0.02NA 120
    rs77720061,2
    C,F,A,H--3154293(+) ATTGTG/ATTAGT 1 -- ds500117Minor allele frequency- A:0.26NS EA NA WA CSA 1746

    HapMap Linkage Disequilibrium report for TUBB2B (3224495 - 3231964 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TUBB2B: --
    Human Gene Mutation Database (HGMD): TUBB2B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBB2B
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBB2B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612850   
    OMIM disorders: 610031  
    UniProtKB/Swiss-Prot: TBB2B_HUMAN, Q9BVA1
  • Polymicrogyria, symmetric or asymmetric (PMGYSA) [MIM:610031]: A malformation of the cortex in which the
    brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination.
    Polymicrogyria is a heterogeneous disorder, considered to be the result of postmigratory abnormal cortical
    organization. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 6 diseases for TUBB2B:    
    About MalaCards
    polymicrogyria, symmetric or asymmetric    polymicrogyria, asymmetric    ocular motility disease    pachygyria
    polymicrogyria    congenital fibrosis of the extraocular muscles 2

    2 diseases from the University of Copenhagen DISEASES database for TUBB2B:
    Lissencephaly     Ocular motility disease

    Find genes that share disorders with TUBB2B           About GenesLikeMe


    Export disorders for TUBB2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TUBB2B gene, integrated from 10 sources (see all 52):
    (articles sorted by number of sources associating them with TUBB2B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. (PubMed id 19465910)1, 2 Jaglin X.H.... Chelly J. (Nat. Genet. 2009)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    5. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)
    6. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. Overlapping cortical malformations and mutations in TUBB2B and TUBA1A. (PubMed id 23361065)1 Cushion T.D....Pilz D.T. (Brain 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 347733 HGNC: 30829 AceView: TUBBandMGC8685 Ensembl:ENSG00000137285 euGenes: HUgn347733
    ECgene: TUBB2B Kegg: 347733 H-InvDB: TUBB2B

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TUBB2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TUBB2B gene:
    Search GeneIP for patents involving TUBB2B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TUBB2B   OriGene RNAi products in human, mouse, rat for TUBB2B  
     OriGene qPCR primer pairs and template standards for TUBB2B   OriGene Protein Over-expression Lysate for TUBB2B  
     OriGene MassSpec something-or-other for TUBB2B   OriGene clones in human, mouse for TUBB2B  
     OriGene qSTAR qPCR primer pairs in human, mouse for TUBB2B   OriGene Purified Protein for TUBB2B  
     OriGene ORF clones in mouse, rat for TUBB2B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TUBB2B   OriGene Custom Protein Services for TUBB2B  

     
     
     Block miRNA regulation of human, mouse, rat TUBB2B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TUBB2B
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBB2B Predesigned siRNA for gene silencing in human, mouse, rat TUBB2B
     QuantiFast Probe-based Assays in human, mouse, rat TUBB2B QuantiTect SYBR Green Assays in human, mouse, rat TUBB2B
     PCR Arrays including human, mouse, rat TUBB2B Search Chromatin IP Primers for TUBB2B
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBB2B  Search GeneGlobe Interaction Network for TUBB2B
     Regulatory tfbs in TUBB2B promoter
     GenScript Custom Purified and Recombinant Proteins Services for TUBB2B GenScript cDNA clones with any tag delivered in your preferred vector for TUBB2B
     GenScript Custom Assay Services for TUBB2B GenScript Custom overexpressing Cell Line Services for TUBB2B
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for TUBB2B
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TUBB2B
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TUBB2B antibodies
     TUBB2B proteins
     TUBB2B lysates
     Antibodies for TUBB2B
     See all of Abcam's Antibodies, Kits and Proteins for TUBB2B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     PureStem Progenitor for TUBB2B: PureStem ES-210, Ecto-ntu Progenitor
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBB2B
     SwitchGear 3'UTR luciferase reporter plasmids for TUBB2B
     SwitchGear Promoter luciferase reporter plasmids for TUBB2B
     Search ThermoFisher Antibodies for TUBB2B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBB2B
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBB2B
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBB2B
     LSBio Antibodies in human, mouse, rat for TUBB2B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for TUBB2B
      Search eBioscience for proteins for TUBB2B
      Search eBioscience for elisas for TUBB2B
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TUBB2B gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4