Aliases for TUBB2B Gene
External Ids for TUBB2B Gene
Previous GeneCards Identifiers for TUBB2B Gene
The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]
GeneCards Summary for TUBB2B Gene
TUBB2B (Tubulin Beta 2B Class IIb) is a Protein Coding gene. Diseases associated with TUBB2B include Polymicrogyria, Symmetric Or Asymmetric and Polymicrogyria Due To Tubb2b Mutation. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBB3.
UniProtKB/Swiss-Prot for TUBB2B Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB2B is implicated in neuronal migration.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).