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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBB Gene

protein-coding   GIFtS: 67
GCID: GC06P030687

Tubulin, Beta Class I

(Previous names: tubulin, beta polypeptide, tubulin, beta)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin, Beta Class I1 2     OK/SW-cl.562
TUBB52 3 5     TUBB12
Tubulin, Beta Polypeptide1 2     Beta 5-Tubulin2
beta1-tubulin1 2     Beta Ib Tubulin2
Class I Beta-Tubulin1 2     Beta-4 Tubulin2
Tubulin Beta-5 Chain2 3     Tubulin Beta Chain2
M402 5     Tubulin Beta Polypeptide2
Tubulin, Beta1     Tubulin Beta-1 Chain2

External Ids:    HGNC: 207781   Entrez Gene: 2030682   Ensembl: ENSG000001962307   OMIM: 1911305   UniProtKB: P074373   

Export aliases for TUBB gene to outside databases

Previous GC identifers: GC06M003138 GC06M003098 GC06P030797 GC06Pc30826 GC06P030489


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TUBB Gene: 
TUBB (tubulin, beta class I) is a protein-coding gene. Diseases associated with TUBB include giant axonal neuropathy, and dementia familial british, and among its related super-pathways are Development Slit-Robo signaling and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is LOC260334.

UniProtKB/Swiss-Prot: TBB5_HUMAN, P07437
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBB Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBB gene promoter:
         GR   STAT1   p53   AP-1   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBB promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.33   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21.33

TUBB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBB gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030687:  view genomic region     (about GC identifiers)

Start:
30,687,978 bp from pter      End:
30,693,203 bp from pter
Size:
5,226 bases      Orientation:
plus strand

6/7 alternative locations (see all 7):
Chr6+,NT_167246 2,036,251-2,041,293      Chr6+,NT_113891.2 2,200,225-2,205,267      Chr6+,NT_167247 2,070,040-2,075,082     
Chr6+,NT_167249 2,020,464-2,025,506      Chr6+,NT_167245 1,981,815-1,986,857      Chr6+,NT_167248 1,981,088-1,986,131     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBB5_HUMAN, P07437 (See protein sequence)
Recommended Name: Tubulin beta chain  
Size: 444 amino acids; 49671 Da
Subunit: Dimer of alpha and beta chains. May interact with RNABP10 (By similarity). Interacts with PIFO. Interacts
with MX1 (By similarity)
Subcellular location: Cytoplasm, cytoskeleton
2 PDB 3D structures from and Proteopedia for TUBB:
3QNZ (3D)        3QO0 (3D)    
Secondary accessions: P05218 Q8WUC1 Q9CY33

Explore the universe of human proteins at neXtProt for TUBB: NX_P07437

Explore proteomics data for TUBB at MOPED 

Post-translational modifications:

  • UniProtKB: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P07437

  • TUBB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUBB Protein Expression
    REFSEQ proteins: NP_821133.1  
    ENSEMBL proteins: 
     ENSP00000339001   ENSP00000365578   ENSP00000379672   ENSP00000379668   ENSP00000391672  
    Reactome Protein details: P07437
    Human Recombinant Protein Products for TUBB: 
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    Novus Biologicals TUBB Proteins
    Novus Biologicals TUBB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005641nuclear envelope lumen IDA19567321
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169

    TUBB for ontologies           About GeneDecksing



    TUBB Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TUB: Tubulins

    5/8 InterPro protein domains (see all 8):
     IPR002453 Beta_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry P07437

    ProtoNet protein and cluster: P07437

    1 Blocks protein domain: IPB002453 Beta tubulin

    UniProtKB/Swiss-Prot: TBB5_HUMAN, P07437
    Domain: The highly acidic C-terminal region may bind cations such as calcium
    Similarity: Belongs to the tubulin family


    TUBB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBB5_HUMAN, P07437
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain

         Genatlas biochemistry entry for TUBB:
    tubulin,beta polypeptide

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005198structural molecule activity TAS12090300
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding IEA--
         
    TUBB for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TUBB:
     Cell cycle / mitosis defect  Decreased cell number, increas  Decreased viability  Increased number of cells in m 
     Increased number of mitotic ce  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUBB 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBB 
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    miRNA
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    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TUBB (see all 26):
    hsa-miR-495 hsa-miR-16-2* hsa-miR-429 hsa-miR-181c hsa-miR-4272 hsa-miR-4260 hsa-miR-421 hsa-miR-339-3p
    SwitchGear 3'UTR luciferase reporter plasmidTUBB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUBB About   (see all 16)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    Cytoplasmic microtubules0.32
    4Recruitment of mitotic centrosome proteins and complexes
    Recruitment of mitotic centrosome proteins and complexes0.83
    Mitotic G2-G2/M phases0.81
    Centrosome maturation0.83
    Loss of Nlp from mitotic centrosomes0.78
    G2/M Transition0.83
    Loss of proteins required for interphase microtubule organization,from the centrosome0.78
    5Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/10 EMD Millipore Pathways for TUBB (see all 10)
        Cytoskeleton remodeling Neurofilaments
    Selected targets of GCR-alpha
    Cytoskeleton remodeling Slit-Robo signaling
    Cytoplasmic microtubules
    Cytoskeleton remodeling Reverse signaling by ephrin B


    2 Cell Signaling Technology (CST) Pathways for TUBB
        Neuroscience
    Cytoskeletal Signaling

    5/10 GeneGo (Thomson Reuters) Pathways for TUBB (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBB
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection


    5/8        Reactome Pathways for TUBB (see all 8)
        Centrosome maturation
    Cell Cycle
    Recruitment of mitotic centrosome proteins and complexes
    G2/M Transition
    Loss of proteins required for interphase microtubule organization,from the centrosome


    3         Kegg Pathways  (Kegg details for TUBB):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection


    TUBB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUBB

    5/983 Interacting proteins for TUBB (P074372, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 983)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3MINT-50383 MINT-50849 MINT-8415355 I2D: score=2 
    ACTBP607092, 3MINT-7945693 MINT-7220149 MINT-7947479 I2D: score=1 
    YWHAZP631042, 3MINT-51021 MINT-8415355 I2D: score=4 
    NFKB2Q006532, 3MINT-48608 MINT-48739 I2D: score=2 
    TRAF1Q130772, 3MINT-49521 MINT-8415355 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006184GTP catabolic process ----
    GO:0006928cellular component movement TAS16130169
    GO:0007017microtubule-based process TAS12090300

    TUBB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TUBB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TUBB available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    2 HMDB Compounds for TUBB    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    7 DrugBank Compounds for TUBB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vinblastine-- 865-21-4targetadduct14619954 9664292 1818332 15579115 18220533
    VinorelbineVinorelbin (see all 7)71486-22-1targetinhibitor17139284 20403547 17016423 7740336 9515574
    ColchicineColchicin (see all 3)64-86-8targetinhibitor20814887 15720245 16166440 19527023
    Vincristine22-Oxovincaleukoblastine (see all 12)57-22-7targetinhibitor19277662 17139284 17016423 20442307
    Epothilone BEPO 906 (see all 3)152044-54-7target--17139284 17016423
    Epothilone D-- 189453-10-9target--17139284 17016423
    Podofilox-- 477-47-4targetinhibitor2011590

    10/106 Novoseek inferred chemical compound relationships for TUBB gene (see all 106)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    paclitaxel 83.4 157 14552587 (4), 7591286 (3), 9132006 (3), 10608867 (3) (see all 91)
    epothilones 82.4 7 16294009 (2), 18083698 (1), 10688884 (1), 12890533 (1) (see all 5)
    epothilone b 80.8 8 18723488 (1), 17938270 (1), 19228735 (1)
    taxane 76.9 22 10688884 (2), 17343904 (2), 15811618 (1), 19863156 (1) (see all 15)
    phomopsin a 76.2 3 15518544 (1), 19072542 (1)
    discodermolide 76 7 11564553 (1), 17002277 (1), 19863156 (1), 19894728 (1) (see all 7)
    colchicine 75.8 61 7766610 (3), 18712858 (3), 11005811 (2), 2011590 (2) (see all 31)
    tbceu 73.2 4 16099845 (1)
    rhizoxin 71.9 1 7788525 (1)
    dolastatin 10 70.7 7 15123603 (4), 10572005 (1), 15518544 (1), 16940412 (1)

    Search CenterWatch for drugs/clinical trials and news about TUBB / TBB5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUBB gene: 
    NM_178014.2  

    Unigene Cluster for TUBB:

    Tubulin, beta class I
    Hs.636480  [show with all ESTs]
    Unigene Representative Sequence: AK098772
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327892(uc003nrl.3) ENST00000330914(uc011dmq.2) ENST00000396389
    ENST00000396384 ENST00000435534

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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBB
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBB

    Additional mRNA sequence: 

    AB062393.1 AF070561.1 AF070593.1 AF070600.1 AF141349.1 AK098772.1 AK297489.1 AK297638.1 
    AK298889.1 AK302195.1 AK302314.1 AK303227.1 AK309684.1 AK316265.1 AK316316.1 BC001002.2 
    BC001896.1 BC001938.1 BC002347.2 BC005838.2 BC007605.1 BC013374.2 BC015889.1 BC019924.1 
    BC020946.1 BC021909.1 BC029323.1 BC062532.1 BC070326.1 BC103746.1 DQ457058.1 EF036509.1 
    V00599.1 

    24/185 DOTS entries (see all 185):

    DT.98082961  DT.91936800  DT.100732278  DT.95266883  DT.100732377  DT.99926884  DT.100732383  DT.95378931 
    DT.99926845  DT.453525  DT.95243839  DT.100732312  DT.100732449  DT.100732330  DT.100656828  DT.100867584 
    DT.91847371  DT.95266886  DT.100732388  DT.100732273  DT.91938078  DT.91938087  DT.91938086  DT.121370837 

    24/6126 AceView cDNA sequences (see all 6126):

    BQ923333 AJ713177 BQ427391 BU189700 BQ071284 BF796364 BG106418 BQ420798 
    AW674943 BQ644311 AA497004 T57290 CR620784 CD643471 BQ647159 BM759838 
    CR608555 BE294607 CF139828 F09606 BU185520 BF922651 CR596438 BM556785 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBB expression in normal human tissues (normalized intensities)      TUBB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACGACCTCG
    TUBB Expression
    About this image


    TUBB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   

    See TUBB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUBB

    SOURCE GeneReport for Unigene cluster: Hs.636480

    UniProtKB/Swiss-Prot: TBB5_HUMAN, P07437
    Tissue specificity: Ubiquitously expressed with highest levels in spleen, thymus and immature brain

        SABiosciences Expression via Pathway-Focused PCR Arrays including TUBB: 
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              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBB gene from 8/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tubb51 , 5 tubulin, beta 5 class I1, 5 91.44(n)1
    100(a)1
      17 (18.70 cM)5
    221541  NM_011655.51  NP_035785.11 
     358339265 
    chicken
    (Gallus gallus)
    Aves TUBB1 tubulin, beta class I 85.36(n)
    100(a)
      396254  NM_205315.1  NP_990646.1 
    lizard
    (Anolis carolinensis)
    Reptilia TUBB6
    Uncharacterized protein
    97(a)
    1 ↔ 1
    GL343438.1(789167-808445)
    zebrafish
    (Danio rerio)
    Actinopterygii tubb51 tubulin, beta 5 83.26(n)
    98.65(a)
      386701  NM_198818.1  NP_942113.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta &bgr;Tub56D3
    betaTub60D1
    cytoskeleton organization and
    biogenesis structural more3
    beta-Tubulin at 60D1
    97(a)
    (best of 4)3
    79.49(n)1
    90.5(a)1
      378881  NM_079118.21  NP_523842.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mec-73
    ben-11
    beta tubulin3
    Protein BEN-11
    94(a)
    (best of 5)3
    74.42(n)1
    90.74(a)1
      X(7810216-7811403)3
    1754611  NM_065327.21  NP_497728.21 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TUB81 tubulin beta-8 chain 71.79(n)
    85.29(a)
      832451  NM_001203444.1  NP_001190373.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06719001 hypothetical protein 77.08(n)
    87.65(a)
      4341810  NM_001064869.1  NP_001058334.1 


    ENSEMBL Gene Tree for TUBB (if available)
    TreeFam Gene Tree for TUBB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBB gene
    LOC2603342  TUBB4B2  TUBB4A2  TUBB82  TUBB2B2  TUBB32  TUBE12  TUBB62  
    TUBB2A2  ENSG000002589472  TUBB12  
    18/30 SIMAP similar genes for TUBB using alignment to 8 protein entries:     TBB5_HUMAN (see all proteins) (see all similar genes):
    XTP3TPATP1    DKFZp566F223    TUBB2A    TUBB2B    TUBB3    TUBB2C
    TUBB4Q    TUBB8    TUBB4B    TUBB6    TUBB4A    TUBB1
    LOC402300    TUBA1    TUBA1A    TUBA1C    TUBA8    DKFZp686L04275

    TUBB for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for TUBB (see all 6)
    PGOHUM00000248382 PGOHUM00000247033 PGOHUM00000247034 PGOHUM00000245460 PGOHUM00000233240


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/189 SNPs in TUBB are shown (see all 189)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1176703751,2
    C,F--30687472(+) AAAAGC/TCCTTG 1 -- us2k11Minor allele frequency- T:0.03EA 120
    rs1870403301,2
    --30687498(+) TCTTTC/TAAAAC 1 -- us2k10--------
    rs31325851,2
    C,F--30687614(-) TGCCTC/GCCCTG 1 -- us2k14Minor allele frequency- G:0.09MN NA WA 332
    rs92959101,2
    C,F,A--30687714(+) TGTCTT/ACCCCA 1 -- us2k15Minor allele frequency- A:0.16MN WA NA EA 452
    rs1443125081,2
    C--30687742(+) CCCCAG/TACTTC 1 -- us2k10--------
    rs743723841,2
    C--30687776(+) TGCTCA/CCTTTT 1 -- us2k10--------
    rs786439641,2
    C--30687777(+) GCTCAC/TTTTTT 1 -- us2k10--------
    rs558464711,2
    C--30687882(+) CCCATC/TCGTCA 1 -- us2k10--------
    rs171893571,2
    C,F--30688067(+) CCAGCC/GCCGGC 1 -- us2k15Minor allele frequency- G:0.19MN WA CSA 215
    rs1114657071,2
    C--30688341(+) CCAAGC/G/TTAAGA 1 -- spd11CSA 1

    HapMap Linkage Disequilibrium report for TUBB (30687978 - 30693203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TUBB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670269CNV Deletion23128226
    esv2731791CNV Deletion23290073
    nsv830626CNV Loss17160897
    dgv1917e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): TUBB
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 191130    OMIM disorders: --

    20/70 diseases for TUBB (see all 70):    About MalaCards
    giant axonal neuropathy    dementia familial british    distal hereditary motor neuropathy, type ii    onchocerciasis
    pleomorphic xanthoastrocytoma    distal hereditary motor neuropathy    guillain-barre syndrome    polyneuropathy
    cerebral amyloid angiopathy    demyelinating polyneuropathy    chronic inflammatory demyelinating polyneuropathy    axonal neuropathy
    brain malformations    ganglioglioma    chondroblastoma    prostatic hypertrophy
    nephronophthisis    leber congenital amaurosis    gastric cancer    breast adenocarcinoma


    TUBB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/46 Novoseek inferred disease relationships for TUBB gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cerebral amyloid angiopathy familial 63.9 2 9928828 (1), 8619814 (1)
    dementia, familial british 51.7 2 9928828 (1), 8619814 (1)
    ovarian carcinoma 49.1 12 17343904 (3), 16294009 (1), 10871860 (1), 11931848 (1) (see all 9)
    recurrent gastric cancer 33.8 1 12861402 (1)
    cancer 33.7 27 19339240 (2), 11555610 (2), 16230404 (1), 10901706 (1) (see all 18)
    nsclc 33.7 27 18613117 (4), 12826311 (2), 19218769 (2), 11605182 (1) (see all 9)
    ovarian cancer 32.9 9 15574781 (2), 18465846 (1), 16288028 (1), 16002208 (1) (see all 7)
    tumors 26.5 45 18781279 (2), 12927047 (2), 19218769 (2), 9276747 (1) (see all 34)
    lung carcinoma 26.1 1 16309172 (1)
    shock 21.8 17 15274120 (1), 16080680 (1), 17522440 (1), 8710793 (1) (see all 17)

    Genetic Association Database (GAD): TUBB
    Human Genome Epidemiology (HuGE) Navigator: TUBB (5 documents)

    Export disorders for TUBB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBB gene, integrated from 9 sources (see all 798):
    (articles sorted by number of sources associating them with TUBB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. (PubMed id 11504633)1, 2, 3, 9 Crabtree D.V.... Adler A.J. (2001)
    2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (2010)
    3. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    4. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    5. The association of the beta1-tubulin Q43P polymorphism with intracerebral hemorrhage in men. (PubMed id 17488662)1, 4 Navarro-Nunez L....Martinez C. (2007)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Mutation of the class I beta-tubulin gene does not predict response to paclitaxel for breast cancer. (PubMed id 12893435)1, 4 Maeno K....Fujimori M. (2003)
    9. Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction. (PubMed id 8270253)1, 3 Volz A....Ziegler A. (1994)
    10. Evolutionary history of a multigene family: an expressed human beta- tubulin gene and three processed pseudogenes. (PubMed id 6688039)1, 2 Lee M.G.-S.... Cowan N.J. (1983)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 203068 HGNC: 20778 AceView: OK\/SW-cl.56 Ensembl:ENSG00000196230 euGenes: HUgn203068
    ECgene: TUBB Kegg: 203068 H-InvDB: TUBB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBB Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Tubulin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUBB gene:
    Search GeneIP for patents involving TUBB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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