TUBAL3 Gene
protein-coding GIFtS: 50
GCID: GC10M005425
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|
tubulin, alpha-like 3
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Aliases
for TUBAL3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tubulin, Alpha-Like 31 2 | | FLJ216651 | | Tubulin Alpha Chain-Like 32 |
Export aliases for TUBAL3 gene to outside databasesPrevious GC identifer: GC10M005390 |
Summaries
for TUBAL3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TBAL3_HUMAN, A6NHL2Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site onthe beta chain and one at a non-exchangeable site on the alpha chain (By similarity)
|
Genomic Views
for TUBAL3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008705.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TUBAL3 gene promoter:
STAT5B NF-1 NF-1/L Lmo2 GATA-1 C/EBPalpha YY1 Gfi-1 E2F-1 E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for TUBAL3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBAL3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10p15.1 Ensembl cytogenetic band: 10p15.1 HGNC cytogenetic band: 10p15.1TUBAL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M005425: view genomic region
(about GC identifiers)
Start:
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5,435,061 bp from pter |
End:
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5,446,793 bp from pter |
Size:
|
11,733 bases |
Orientation:
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minus strand |
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Proteins
for TUBAL3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TBAL3_HUMAN, A6NHL2 (See
protein sequence)Recommended Name: Tubulin alpha chain-like 3 Size: 446 amino acids; 49909 Da
Subcellular location: Cytoplasm, cytoskeleton (By similarity)
Secondary accessions: B4DKL2 Q4QQJ5 Q9H6Z0Alternative splicing: 2 isoforms: A6NHL2-1 A6NHL2-2 Explore the universe of human proteins at neXtProt for TUBAL3: NX_A6NHL2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A6NHL2
TUBAL3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001165335.1 NP_079079.1
ENSEMBL proteins: ENSP00000369784 ENSP00000418799
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TUBAL3 for ontologies About GeneDecksing
TUBAL3 Antibody Products:
Assay Products for TUBAL3: |
Protein
Domains /
Families
for TUBAL3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TUBAL3 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry A6NHL2ProtoNet protein and cluster: A6NHL2 UniProtKB/Swiss-Prot: TBAL3_HUMAN, A6NHL2Similarity: Belongs to the tubulin family |
Function
for TUBAL3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TBAL3_HUMAN, A6NHL2Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site onthe beta chain and one at a non-exchangeable site on the alpha chain (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBAL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBAL3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TUBAL3 (NM_024803) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TUBAL3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBAL3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBAL3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TUBAL3 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TUBAL3:
|
Pathways & Interactions
for TUBAL3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Pathogenic Escherichia coli infection | | | 2 | wtCFTR and deltaF508 traffic / Membrane expression (norm and CF) | | | 3 | Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway | | | 4 | Cell cycle_Spindle assembly and chromosome separation | | | 5 | Cytoskeleton remodeling_Reverse signaling by ephrin B | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10  GeneGo (Thomson Reuters) Pathways for TUBAL3 (see all 10)
2  BioSystems Pathways for TUBAL3
3 
Kegg Pathways (Kegg details for TUBAL3):
TUBAL3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUBAL3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/21 Interacting proteins for TUBAL3 (A6NHL23 ENSP000003697844) via UniProtKB, MINT, STRING, and/or I2D (see all 21)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
IEA | -- | | GO:0051258 | protein polymerization |
IEA | -- |
TUBAL3 for ontologies About GeneDecksing
|
Drugs & Compounds
for TUBAL3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TUBAL3
1 HMDB Compound for TUBAL3 About this table
Search CenterWatch for drugs/clinical trials and news about TUBAL3 / TBAL3
|
Transcripts
for TUBAL3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TUBAL3 gene (2 alternative transcripts): NM_001171864.1 NM_024803.2 Unigene Cluster for TUBAL3: Tubulin, alpha-like 3 Hs.163079 [show with all ESTs]Unigene Representative Sequence: AK0253182 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380419(uc001ihz.3 uc001ihy.3) ENST00000479328
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBAL3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBAL3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TUBAL3 (NM_024803) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TUBAL3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBAL3 |
Additional cDNA sequence: AK025318.1 AK296616.1 BC098247.1 BC099716.1 BC105634.1 2 DOTS entries: DT.75168907 DT.121221378 6 AceView cDNA sequences: AK025318 BX097071 BG434122 NM_024803 CB109674 AW004763
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TUBAL3 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b |
|---|
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| SP1: | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TUBAL3
|
Expression
for TUBAL3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TUBAL3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTACATTTT
About this image
See TUBAL3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUBAL3
SOURCE GeneReport for Unigene cluster: Hs.163079
SABiosciences Expression via Pathway-Focused PCR Array including TUBAL3: | Gap Junctions in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBAL3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUBAL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBAL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBAL3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBAL3 |
Orthologs
for TUBAL3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TUBAL3 gene from 2/11 species (see all 11) About this table
ENSEMBL Gene Tree for TUBAL3 (if available)
TreeFam Gene Tree for TUBAL3 (if available) |
Paralogs
for TUBAL3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TUBAL3 gene
- TUBA3C2 TUBA4A2 TUBA1B2 TUBA1A2 TUBA3E2 TUBA1C2 TUBA3D2 TUBA82
18/28 SIMAP similar genes for TUBAL3 using alignment to 1 protein entry: TBAL3_HUMAN(see all similar genes):TUBA1A DKFZp686L04275 TUBA8 TUBA2 TUBA3C TUBA3D
TUBA3E TUBA4A TUBA4B TUBA1C MGC16703 TUBA1B
TUBB4Q XTP3TPATP1 TUBB2A TUBB3 DKFZp566F223 TUBB4A
TUBAL3 for paralogs About GeneDecksing
|
Genomic Variants
for TUBAL3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TUBAL3 (5435061 - 5446793 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TUBAL3: --
Human Gene Mutation Database (HGMD): TUBAL3
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBAL3 |
|
Disorders
/ Diseases
for TUBAL3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TUBAL3 for disorders About GeneDecksing
2  diseases for TUBAL3: About MalaCardsmalaria neuronitis
Human Genome Epidemiology (HuGE) Navigator: TUBAL3 (2 documents)
Export disorders for TUBAL3 gene to outside databases
|
Publications
for TUBAL3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TUBAL3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TUBAL3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TUBAL3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TUBAL3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TUBAL3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TUBAL3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TUBAL3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TUBAL3 gene:
Search GeneIP for patents involving TUBAL3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TUBAL3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TUBAL3 | | OriGene shRNA RFP for TUBAL3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBAL3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBAL3 | | | OriGene Protein Over-expression Lysate for TUBAL3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TUBAL3 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBAL3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBAL3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TUBAL3 | | OriGene Custom Protein Services for TUBAL3 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUBAL3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBAL3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBAL3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBAL3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBAL3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBAL3 |
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 |  |  |  | |
| | | | Search Tocris compounds for TUBAL3 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBAL3 |
|  |  |  | | | | Search ThermoFisher Antibodies for TUBAL3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBAL3 |
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