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Aliases for TUBAL3 Gene

Aliases for TUBAL3 Gene

  • Tubulin Alpha Like 3 2 3 5
  • Tubulin, Alpha-Like 3 2

External Ids for TUBAL3 Gene

Previous GeneCards Identifiers for TUBAL3 Gene

  • GC10M005390

Summaries for TUBAL3 Gene

GeneCards Summary for TUBAL3 Gene

TUBAL3 (Tubulin Alpha Like 3) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling and Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA4A.

UniProtKB/Swiss-Prot for TUBAL3 Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBAL3 Gene

Genomics for TUBAL3 Gene

Regulatory Elements for TUBAL3 Gene

Enhancers for TUBAL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TUBAL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBAL3 Gene

Chromosome:
10
Start:
5,393,098 bp from pter
End:
5,404,830 bp from pter
Size:
11,733 bases
Orientation:
Minus strand

Genomic View for TUBAL3 Gene

Genes around TUBAL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBAL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBAL3 Gene

Proteins for TUBAL3 Gene

  • Protein details for TUBAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHL2-TBAL3_HUMAN
    Recommended name:
    Tubulin alpha chain-like 3
    Protein Accession:
    A6NHL2
    Secondary Accessions:
    • B4DKL2
    • Q4QQJ5
    • Q9H6Z0

    Protein attributes for TUBAL3 Gene

    Size:
    446 amino acids
    Molecular mass:
    49909 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Alternative splice isoforms for TUBAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBAL3 Gene

Post-translational modifications for TUBAL3 Gene

  • Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.
  • Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBAL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBAL3 Gene

Domains & Families for TUBAL3 Gene

Gene Families for TUBAL3 Gene

Suggested Antigen Peptide Sequences for TUBAL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NHL2

UniProtKB/Swiss-Prot:

TBAL3_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBAL3: view

Function for TUBAL3 Gene

Molecular function for TUBAL3 Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Gene Ontology (GO) - Molecular Function for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBAL3: view
genes like me logo Genes that share phenotypes with TUBAL3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBAL3 Gene

Localization for TUBAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBAL3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBAL3 Gene COMPARTMENTS Subcellular localization image for TUBAL3 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBAL3: view

Pathways & Interactions for TUBAL3 Gene

genes like me logo Genes that share pathways with TUBAL3: view

Gene Ontology (GO) - Biological Process for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA --
genes like me logo Genes that share ontologies with TUBAL3: view

No data available for SIGNOR curated interactions for TUBAL3 Gene

Drugs & Compounds for TUBAL3 Gene

(1) Drugs for TUBAL3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with TUBAL3: view

Transcripts for TUBAL3 Gene

mRNA/cDNA for TUBAL3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUBAL3 Gene

Tubulin, alpha-like 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBAL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TUBAL3 Gene

GeneLoc Exon Structure for
TUBAL3
ECgene alternative splicing isoforms for
TUBAL3

Expression for TUBAL3 Gene

mRNA expression in normal human tissues for TUBAL3 Gene

mRNA differential expression in normal tissues according to GTEx for TUBAL3 Gene

This gene is overexpressed in Colon - Transverse (x19.1), Small Intestine - Terminal Ileum (x14.2), and Kidney - Cortex (x8.3).

Protein differential expression in normal tissues from HIPED for TUBAL3 Gene

This gene is overexpressed in Brain (44.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBAL3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TUBAL3 Gene:

TUBAL3

SOURCE GeneReport for Unigene cluster for TUBAL3 Gene:

Hs.163079
genes like me logo Genes that share expression patterns with TUBAL3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TUBAL3 Gene

Orthologs for TUBAL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBAL3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TUBAL3 34
  • 84.68 (n)
  • 84.3 (a)
TUBAL3 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubal3 34
  • 81.76 (n)
  • 82.74 (a)
Tubal3 16
Tubal3 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBAL3 34
  • 99.1 (n)
  • 99.33 (a)
TUBAL3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubal3 34
  • 81.5 (n)
  • 82.2 (a)
cow
(Bos Taurus)
Mammalia TUBAL3 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBAL3 35
  • 72 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta alphaTub67C 35
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tba-6 35
  • 67 (a)
OneToMany
tba-7 35
  • 69 (a)
OneToMany
tba-8 35
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB3 35
  • 65 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7910 35
  • 69 (a)
OneToOne
Species where no ortholog for TUBAL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TUBAL3 Gene

ENSEMBL:
Gene Tree for TUBAL3 (if available)
TreeFam:
Gene Tree for TUBAL3 (if available)

Paralogs for TUBAL3 Gene

Paralogs for TUBAL3 Gene

genes like me logo Genes that share paralogs with TUBAL3: view

Variants for TUBAL3 Gene

Sequence variations from dbSNP and Humsavar for TUBAL3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11818372 - 5,394,453(+) CCACA(C/G)TGTTC reference, missense
rs34080891 - 5,394,110(-) CCCTC(C/T)GGTTT reference, missense
rs3888366 -- 5,398,440(-) TTTTT(G/T)TTTTT intron-variant
rs7097775 -- 5,393,955(+) AAGCA(A/G)GCAGT reference, synonymous-codon
rs7474645 -- 5,402,054(+) TGCAT(A/G)ATTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBAL3 Gene

Variant ID Type Subtype PubMed ID
nsv1045141 CNV gain 25217958
nsv549886 CNV loss 21841781

Variation tolerance for TUBAL3 Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.06; 68.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBAL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBAL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBAL3 Gene

Disorders for TUBAL3 Gene

Relevant External Links for TUBAL3

Genetic Association Database (GAD)
TUBAL3
Human Genome Epidemiology (HuGE) Navigator
TUBAL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBAL3

No disorders were found for TUBAL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBAL3 Gene

Publications for TUBAL3 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 65
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 65
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3 65
  5. Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. (PMID: 21360678) Skarra D.V. … Honkanen R.E. (Proteomics 2011) 3 65

Products for TUBAL3 Gene

Sources for TUBAL3 Gene

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