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Aliases for TUBAL3 Gene

Aliases for TUBAL3 Gene

  • Tubulin, Alpha-Like 3 2 3

External Ids for TUBAL3 Gene

Summaries for TUBAL3 Gene

GeneCards Summary for TUBAL3 Gene

TUBAL3 (Tubulin, Alpha-Like 3) is a Protein Coding gene. Among its related pathways are EphB-EphrinB Signaling and Development Slit-Robo signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton.

UniProtKB/Swiss-Prot for TUBAL3 Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBAL3 Gene

Genomics for TUBAL3 Gene

Genomic Location for TUBAL3 Gene

Start:
5,393,098 bp from pter
End:
5,404,830 bp from pter
Size:
11,733 bases
Orientation:
Minus strand

Genomic View for TUBAL3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBAL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBAL3 Gene

Regulatory Elements for TUBAL3 Gene

Proteins for TUBAL3 Gene

  • Protein details for TUBAL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NHL2-TBAL3_HUMAN
    Recommended name:
    Tubulin alpha chain-like 3
    Protein Accession:
    A6NHL2
    Secondary Accessions:
    • B4DKL2
    • Q4QQJ5
    • Q9H6Z0

    Protein attributes for TUBAL3 Gene

    Size:
    446 amino acids
    Molecular mass:
    49909 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells

    Alternative splice isoforms for TUBAL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBAL3 Gene

Proteomics data for TUBAL3 Gene at MOPED

Post-translational modifications for TUBAL3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys401 and Lys408

Other Protein References for TUBAL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBAL3 Gene

Domains for TUBAL3 Gene

Gene Families for TUBAL3 Gene

HGNC:
  • TUB :Tubulins

UniProtKB/Swiss-Prot:

TBAL3_HUMAN
Family:
  • Belongs to the tubulin family.:
    • A6NHL2
genes like me logo Genes that share domains with TUBAL3: view

Function for TUBAL3 Gene

Molecular function for TUBAL3 Gene

UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Gene Ontology (GO) - Molecular Function for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBAL3: view

Phenotypes for TUBAL3 Gene

genes like me logo Genes that share phenotypes with TUBAL3: view

miRNA for TUBAL3 Gene

miRTarBase miRNAs that target TUBAL3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBAL3 Gene

Localization for TUBAL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBAL3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBAL3 Gene COMPARTMENTS Subcellular localization image for TUBAL3 gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with TUBAL3: view

Pathways for TUBAL3 Gene

genes like me logo Genes that share pathways with TUBAL3: view

Interacting Proteins for TUBAL3 Gene

Gene Ontology (GO) - Biological Process for TUBAL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007017 microtubule-based process IEA --
GO:0008152 metabolic process IEA --
GO:0051258 protein polymerization IEA --
genes like me logo Genes that share ontologies with TUBAL3: view

Compounds for TUBAL3 Gene

(1) HMDB Compounds for TUBAL3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with TUBAL3: view

Transcripts for TUBAL3 Gene

mRNA/cDNA for TUBAL3 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUBAL3 Gene

Tubulin, alpha-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBAL3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1:
SP2: -

Relevant External Links for TUBAL3 Gene

GeneLoc Exon Structure for
TUBAL3
ECgene alternative splicing isoforms for
TUBAL3

Expression for TUBAL3 Gene

mRNA expression in normal human tissues for TUBAL3 Gene

mRNA differential expression in normal tissues according to GTEx for TUBAL3 Gene

This gene is overexpressed in Colon - Transverse (19.1), Small Intestine - Terminal Ileum (14.2), and Kidney - Cortex (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBAL3 Gene

SOURCE GeneReport for Unigene cluster for TUBAL3 Gene Hs.163079

genes like me logo Genes that share expressions with TUBAL3: view

Orthologs for TUBAL3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBAL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBAL3 36
  • 99.1 (n)
  • 99.33 (a)
TUBAL3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBAL3 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TUBAL3 36
  • 84.68 (n)
  • 84.3 (a)
TUBAL3 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tubal3 36
  • 81.76 (n)
  • 82.74 (a)
Tubal3 16
Tubal3 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBAL3 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tubal3 36
  • 81.5 (n)
  • 82.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta alphaTub67C 37
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea tba-6 37
  • 67 (a)
OneToMany
tba-7 37
  • 69 (a)
OneToMany
tba-8 37
  • 66 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB3 37
  • 65 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7910 37
  • 69 (a)
OneToOne
Species with no ortholog for TUBAL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TUBAL3 Gene

ENSEMBL:
Gene Tree for TUBAL3 (if available)
TreeFam:
Gene Tree for TUBAL3 (if available)

Paralogs for TUBAL3 Gene

genes like me logo Genes that share paralogs with TUBAL3: view

No data available for Paralogs for TUBAL3 Gene

Variants for TUBAL3 Gene

Sequence variations from dbSNP and Humsavar for TUBAL3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs3255 -- 5,393,218(+) AACTT(C/T)AGGAT utr-variant-3-prime
rs3888366 -- 5,398,440(-) TTTTT(G/T)TTTTT intron-variant
rs4881435 -- 5,404,979(+) CAACC(C/T)GGGAT upstream-variant-2KB
rs4881436 -- 5,405,002(+) CAGCT(A/G)CAGAT upstream-variant-2KB
rs5782824 -- 5,398,752(+) GTTTT(-/T)GCAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBAL3 Gene

Variant ID Type Subtype PubMed ID
nsv894783 CNV Loss 21882294
nsv894792 CNV Gain 21882294

Relevant External Links for TUBAL3 Gene

HapMap Linkage Disequilibrium report
TUBAL3

Disorders for TUBAL3 Gene

Relevant External Links for TUBAL3

Genetic Association Database (GAD)
TUBAL3
Human Genome Epidemiology (HuGE) Navigator
TUBAL3
genes like me logo Genes that share disorders with TUBAL3: view

No data available for UniProtKB/Swiss-Prot for TUBAL3 Gene

Publications for TUBAL3 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  2. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
  3. Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. (PMID: 21360678) Skarra D.V. … Honkanen R.E. (Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for TUBAL3 Gene

Sources for TUBAL3 Gene

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