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Aliases & Descriptions for TUBA8
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000196216 2 | | TUBAL2 2, 3, 5 |
| | | Descriptions |
|---|
| Alpha-tubulin 8 3 | | Tubulin alpha chain-like 2 3 | | tubulin, alpha 8 2 | | tubulin, alpha-like 2 2 |
|
| | Search outside databases for aliases for TUBA8 genePrevious GC identifer: GC22P015533 |
Summaries for TUBA8(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TBA8_HUMAN, Q9NY65Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chainGene Wiki entry for TUBA8 |
Genomic Location for TUBA8
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TUBA8 gene 
Entrez Gene cytogenetic band: 22q11.1 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11TUBA8 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P016968:
(about GC identifiers)
Start:
|
16,973,453 bp from pter |
End:
|
16,994,498 bp from pter |
Size:
|
21,046 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000022.9 NT_011519.10
| Proteins for TUBA8
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TBA8_HUMAN, Q9NY65 (See
protein sequence)Recommended Name: Tubulin alpha-8 chain Size: 449 amino acids; 50094 Da
Subunit: Dimer of alpha and beta chains
Miscellaneous: This tubulin does not have a C-terminal tyrosine
Secondary accessions: Q2M3N4Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_061816.1
ENSEMBL proteins: ENSP00000318575 ENSP00000333326
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TUBA8 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005874 | microtubule |
IEA | -- | | GO:0043234 | protein complex |
IEA | -- | About this table
Antibodies for TUBA8: Assays for TUBA8: | Protein
Domains/ Families for TUBA8(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NY65
ProtoNet protein and cluster: Q9NY65 1 Blocks protein family: IPB002452 Alpha tubulin signature
UniProtKB/Swiss-Prot: TBA8_HUMAN, Q9NY65Similarity: Belongs to the tubulin family | Gene Function for TUBA8
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018943
Applied Biosystems Silencer® siRNAs for TUBA8
Sigma-Aldrich siRNA and siRNA Panels for TUBA8  Sigma-Aldrich shRNA for TUBA8  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018943                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018943                                  untagged cDNA clone in CMV expression vector: NM_018943 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018943
UniProtKB/Swiss-Prot: TBA8_HUMAN, Q9NY65Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TUBA8
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for TUBA8 (Your Favorite Gene powered by Ingenuity) 
5/31 Interacting proteins for TUBA8 (ENSP000003185753 Q9NY652) via UniProtKB, MINT, and/or STRING (see all 31
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
IEA | -- | | GO:0051258 | protein polymerization |
IEA | -- | About this table
|
Drugs & Compounds for TUBA8(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for TUBA8 |
Compounds for TUBA8 available from Tocris Bioscience About this table
|
Transcripts for TUBA8(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018943
Sigma-Aldrich siRNA and siRNA Panels for TUBA8  Sigma-Aldrich shRNA for TUBA8  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018943 REFSEQ mRNAs for TUBA8 gene: NM_018943.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018943               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018943                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018943                                  untagged cDNA clone in CMV expression vector: NM_018943  Additional cDNA sequence: AJ245922.1 AK056947.1 AK315316.1 BC074827.2 BC104845.1 BX537702.1 CR456600.1 CR620426.1 4 DOTS entries: DT.428261 DT.95253738 DT.100658425 DT.75173237 24/181 AceView cDNA sequences (see all 181
):CA433269 BQ100690 BC047320 CA427902 AA676826 AI869536 BQ575902 C21355 BC016280 AJ245922 AI636019 BC074827 CA424779 F30278 BF059267 CR620426 BI917830 NM_018943 H55532 AW235279 BX537702 F36680 CA433324 BQ943945
highest scoring ESTs for TUBA8:AA180063 AJ245922 AJ572492 AK056947 BF195571 BM511724 BM670545 CR456600 F16034 F22723 Unigene Cluster for TUBA8: Tubulin, alpha 8 Hs.137400 [show with all ESTs]Unigene Representative Sequence: CR620426
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TUBA8
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TUBA8
2 Ensembl transcripts including schematic representations: ENST00000316027
ENST00000330423
|
Expression for TUBA8
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TUBA8 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TUBA8
1 / 2 / 3 3 probe-sets matching TUBA8 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACGCCAAGC
SOURCE GeneReport for Unigene cluster: Hs.137400 UniProtKB/Swiss-Prot: TBA8_HUMAN, Q9NY65Tissue specificity: Preferentially expressed in heart, skeletal muscle and testis |
Orthologs for TUBA8
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TUBA8 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for TUBA8
ENSEMBL Gene Tree for TUBA8 | Paralogs for TUBA8(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TUBA8 gene
- TUBA3C2 TUBA3E2 TUBA3D2
|
SNPs/Variants for TUBA8(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TUBA8 (up to first 250kb)
|
Disorders & Mutations for TUBA8
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605742
Genetic Association Database: TUBA8 Human Genome Epidemiology Navigator: TUBA8 (1 document)
|
Medical News for TUBA8(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TUBA8 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for TUBA8 gene (see all 20
):- TUBA8: a new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. (PubMed id 10772959)1, 2, 3, 4 Stanchi F.... Valle G. (2000)
- Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PubMed id 16380905)3, 6 Fallin M.D....Pulver A.E. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)3, 4 Collins J.E.... Dunham I. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2, 3 Dunham I....O'Brien K.P. (1999)
- Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. (PubMed id 16327313)3 Canani R.B....Guarino A. (2006)
- HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? (PubMed id 15698476)3 Giacca M. (2005)
- Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. (PubMed id 16148047)3 Valenzuela-Fernandez A....Sanchez-Madrid F. (2005)
- HIV-1 Tat protein enhances microtubule polymerization. (PubMed id 15691386)3 de Mareuil J....Loret E.P. (2005)
- The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. (PubMed id 15331610)3 Campbell G.R....Loret E.P. (2004)
|
Search for TUBA8
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TUBA8
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TUBA8
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TUBA8(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TUBA8(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TUBA8:

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 |  |  |
| | | | Tocris compounds for TUBA8 |
|
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Incremental update: 13 Oct 2009
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