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Aliases for TUBA4B Gene

Aliases for TUBA4B Gene

  • Tubulin Alpha 4b 2 3 5
  • Tubulin, Alpha 4b (Pseudogene) 2 3
  • Tubulin, Alpha 4 2 3
  • TUBA4 3 4
  • Putative Tubulin-Like Protein Alpha-4B 3
  • Alpha-Tubulin 4B 4

External Ids for TUBA4B Gene

Previous HGNC Symbols for TUBA4B Gene

  • TUBA4

Previous GeneCards Identifiers for TUBA4B Gene

  • GC02P219827
  • GC02P220118
  • GC02P211970

Summaries for TUBA4B Gene

GeneCards Summary for TUBA4B Gene

TUBA4B (Tubulin Alpha 4b) is a Protein Coding gene. Among its related pathways are Development Slit-Robo signaling and EphB-EphrinB Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA1A.

Tocris Summary for TUBA4B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Additional gene information for TUBA4B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA4B Gene

Genomics for TUBA4B Gene

GeneHancer (GH) Regulatory Elements for TUBA4B Gene

Promoters and enhancers for TUBA4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I219244 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.3 -3.1 -3125 11.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 GLB1L TUBA4A STK16 ZFAND2B ANKZF1 ATG9A DNAJB2 MIR153-1 PTPRN ENSG00000230432
GH02I219227 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 7.9 -23.6 -23635 3.4 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ANKZF1 ATG9A USP37 NHEJ1 DNPEP GLB1L ABCB6 AAMP CNOT9 TUBA4B
GH02I219277 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.8 +26.4 26390 4.5 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 NFYC DNAJB2 GC02P219281 PIR48822 TUBA4A PTPRN OBSL1 ENSG00000269068 GLB1L TUBA4B
GH02I219216 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.3 -35.0 -34976 3.5 CLOCK SMAD1 FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B ABCB6 GC02M219219 PIR34268 TUBA4B ATG9A ZFAND2B
GH02I219121 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.1 -128.2 -128174 7.2 CLOCK ATF1 FOXA2 ARID4B YBX1 TCF12 FOS ATF7 RUNX3 RXRA SLC23A3 NHEJ1 IHH LOC100129175 MIR375 FEV CRYBA2 LINC00608 CNPPD1 RETREG2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TUBA4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TUBA4B gene promoter:

Genomic Locations for TUBA4B Gene

Genomic Locations for TUBA4B Gene
chr2:219,253,243-219,272,188
(GRCh38/hg38)
Size:
18,946 bases
Orientation:
Plus strand
chr2:220,117,965-220,136,910
(GRCh37/hg19)

Genomic View for TUBA4B Gene

Genes around TUBA4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBA4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBA4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA4B Gene

Proteins for TUBA4B Gene

  • Protein details for TUBA4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H853-TBA4B_HUMAN
    Recommended name:
    Putative tubulin-like protein alpha-4B
    Protein Accession:
    Q9H853

    Protein attributes for TUBA4B Gene

    Size:
    241 amino acids
    Molecular mass:
    27551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBA4B Gene

Post-translational modifications for TUBA4B Gene

  • Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.
  • Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.

Other Protein References for TUBA4B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBA4B Gene

Domains & Families for TUBA4B Gene

Gene Families for TUBA4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TUBA4B Gene

Suggested Antigen Peptide Sequences for TUBA4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H853

UniProtKB/Swiss-Prot:

TBA4B_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA4B: view

Function for TUBA4B Gene

Phenotypes From GWAS Catalog for TUBA4B Gene

Gene Ontology (GO) - Molecular Function for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBA4B: view
genes like me logo Genes that share phenotypes with TUBA4B: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TUBA4B Gene

Localization for TUBA4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA4B Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBA4B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TUBA4B Gene

Pathways & Interactions for TUBA4B Gene

genes like me logo Genes that share pathways with TUBA4B: view

Interacting Proteins for TUBA4B Gene

Gene Ontology (GO) - Biological Process for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TUBA4B: view

No data available for SIGNOR curated interactions for TUBA4B Gene

Drugs & Compounds for TUBA4B Gene

(4) Drugs for TUBA4B Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
CYT997 Investigational Pharma Target 0
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBA4B Gene - From:

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TUBA4B Gene

Compound Action Cas Number
MPC 6827 hydrochloride Inhibitor of microtubule polymerization; antimitotic and antitumor 917369-31-4
Nocodazole Microtubule inhibitor 31430-18-9
Noscapine hydrochloride Tubulin inhibitor; induces apoptosis 912-60-7
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBA4B: view

Transcripts for TUBA4B Gene

mRNA/cDNA for TUBA4B Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUBA4B Gene

Tubulin, alpha 4b (pseudogene):
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA4B Gene

No ASD Table

Relevant External Links for TUBA4B Gene

GeneLoc Exon Structure for
TUBA4B
ECgene alternative splicing isoforms for
TUBA4B

Expression for TUBA4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TUBA4B Gene

mRNA differential expression in normal tissues according to GTEx for TUBA4B Gene

This gene is overexpressed in Fallopian Tube (x12.0), Cervix - Endocervix (x5.5), Brain - Hypothalamus (x5.0), Brain - Caudate (basal ganglia) (x4.9), Lung (x4.8), and Kidney - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for TUBA4B Gene

This gene is overexpressed in Ovary (29.0), Liver (12.9), Brain (9.9), and Prostate (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TUBA4B Gene



Protein tissue co-expression partners for TUBA4B Gene

NURSA nuclear receptor signaling pathways regulating expression of TUBA4B Gene:

TUBA4B

SOURCE GeneReport for Unigene cluster for TUBA4B Gene:

Hs.664469
genes like me logo Genes that share expression patterns with TUBA4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBA4B Gene

Orthologs for TUBA4B Gene

Evolution for TUBA4B Gene

ENSEMBL:
Gene Tree for TUBA4B (if available)
TreeFam:
Gene Tree for TUBA4B (if available)

No data available for Orthologs for TUBA4B Gene

Paralogs for TUBA4B Gene

Paralogs for TUBA4B Gene

genes like me logo Genes that share paralogs with TUBA4B: view

Variants for TUBA4B Gene

Sequence variations from dbSNP and Humsavar for TUBA4B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs730880029 pathogenic, Amyotrophic lateral sclerosis 22 with or without frontotemporal dementia 219,251,266(+) T/G upstream_transcript_variant
rs1000084278 -- 219,257,378(+) C/T intron_variant
rs1000850288 -- 219,268,687(+) G/C intron_variant
rs1000897360 -- 219,265,239(+) G/A intron_variant
rs1000928012 -- 219,265,566(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TUBA4B Gene

Variant ID Type Subtype PubMed ID
esv25352 CNV loss 19812545
esv3594358 CNV loss 21293372
esv3594359 CNV loss 21293372
esv3893555 CNV loss 25118596
nsv1131551 CNV deletion 24896259
nsv508885 CNV insertion 20534489
nsv527936 CNV loss 19592680
nsv584501 CNV loss 21841781
nsv834543 CNV loss 17160897
nsv954842 CNV deletion 24416366
nsv979176 CNV duplication 23825009

Additional Variant Information for TUBA4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBA4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TUBA4B Gene

Disorders for TUBA4B Gene

Additional Disease Information for TUBA4B

No disorders were found for TUBA4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBA4B Gene

Publications for TUBA4B Gene

  1. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PMID: 22360420) Martins-de-Souza D … Bahn S (Journal of proteome research 2012) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. (PMID: 3785200) Villasante A … Cowan NJ (Molecular and cellular biology 1986) 2 3 58
  4. Low Expression LncRNA TUBA4B is a Poor Predictor of Prognosis and Regulates Cell Proliferation in Non-Small Cell Lung Cancer. (PMID: 27411923) Chen J … Pan Q (Pathology oncology research : POR 2017) 3 58
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R … Boisvert FM (Molecular & cellular proteomics : MCP 2015) 3 58

Products for TUBA4B Gene

Sources for TUBA4B Gene

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