Aliases for TUBA4B Gene
External Ids for TUBA4B Gene
Previous HGNC Symbols for TUBA4B Gene
Previous GeneCards Identifiers for TUBA4B Gene
GeneCards Summary for TUBA4B Gene
TUBA4B (Tubulin, Alpha 4b) is a Pseudogene. Among its related pathways are EphB-EphrinB Signaling and Development Slit-Robo signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.