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Aliases for TUBA4B Gene

Aliases for TUBA4B Gene

  • Tubulin Alpha 4b 2 3 5
  • Tubulin, Alpha 4b (Pseudogene) 2 3
  • Tubulin, Alpha 4 2 3
  • Alpha-Tubulin 4B 3 4
  • TUBA4 3 4
  • Putative Tubulin-Like Protein Alpha-4B 3

External Ids for TUBA4B Gene

Previous HGNC Symbols for TUBA4B Gene

  • TUBA4

Previous GeneCards Identifiers for TUBA4B Gene

  • GC02P219827
  • GC02P220118
  • GC02P211970

Summaries for TUBA4B Gene

GeneCards Summary for TUBA4B Gene

TUBA4B (Tubulin Alpha 4b) is a Pseudogene. Among its related pathways are Development Slit-Robo signaling and Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA1C.

Tocris Summary for TUBA4B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA4B Gene

Genomics for TUBA4B Gene

Regulatory Elements for TUBA4B Gene

Enhancers for TUBA4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TUBA4B on UCSC Golden Path with GeneCards custom track

Promoters for TUBA4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TUBA4B Gene

219,253,243 bp from pter
219,272,188 bp from pter
18,946 bases
Plus strand

Genomic View for TUBA4B Gene

Genes around TUBA4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBA4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBA4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA4B Gene

Proteins for TUBA4B Gene

  • Protein details for TUBA4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative tubulin-like protein alpha-4B
    Protein Accession:

    Protein attributes for TUBA4B Gene

    241 amino acids
    Molecular mass:
    27551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBA4B Gene

Post-translational modifications for TUBA4B Gene

  • Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear.
  • Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group. Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TUBA4B Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for TUBA4B Gene

Domains & Families for TUBA4B Gene

Gene Families for TUBA4B Gene

Protein Domains for TUBA4B Gene

Suggested Antigen Peptide Sequences for TUBA4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tubulin family.
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA4B: view

Function for TUBA4B Gene

Gene Ontology (GO) - Molecular Function for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBA4B: view
genes like me logo Genes that share phenotypes with TUBA4B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TUBA4B Gene

Localization for TUBA4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA4B Gene

Cytoplasm, cytoskeleton.

Gene Ontology (GO) - Cellular Components for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBA4B: view

No data available for Subcellular locations from COMPARTMENTS for TUBA4B Gene

Pathways & Interactions for TUBA4B Gene

genes like me logo Genes that share pathways with TUBA4B: view

Interacting Proteins for TUBA4B Gene

Gene Ontology (GO) - Biological Process for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with TUBA4B: view

No data available for SIGNOR curated interactions for TUBA4B Gene

Drugs & Compounds for TUBA4B Gene

(4) Drugs for TUBA4B Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 106
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1880
CYT997 Investigational Pharma Target 0
Vinblastine sulfate Pharma Anti-mitotic agent, Disrupts microtubules 0

(2) Additional Compounds for TUBA4B Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolastatin 10 trifluoroacetate

(5) Tocris Compounds for TUBA4B Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Docetaxel Microtubule stabilizer 114977-28-5
Dolastatin 10 trifluoroacetate Tubulin polymerization inhibitor
MMAE Potent dolastatin 10 analog; antitumor 474645-27-7
Vinblastine sulfate Disrupts microtubules 143-67-9
genes like me logo Genes that share compounds with TUBA4B: view

Transcripts for TUBA4B Gene

mRNA/cDNA for TUBA4B Gene

(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUBA4B Gene

Tubulin, alpha 4b (pseudogene):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA4B Gene

No ASD Table

Relevant External Links for TUBA4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBA4B Gene

mRNA expression in normal human tissues for TUBA4B Gene

mRNA differential expression in normal tissues according to GTEx for TUBA4B Gene

This gene is overexpressed in Fallopian Tube (x12.0), Cervix - Endocervix (x5.5), Brain - Hypothalamus (x5.0), Brain - Caudate (basal ganglia) (x4.9), Lung (x4.8), and Kidney - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for TUBA4B Gene

This gene is overexpressed in Ovary (29.0), Liver (12.9), Brain (9.9), and Prostate (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TUBA4B Gene

Protein tissue co-expression partners for TUBA4B Gene

NURSA nuclear receptor signaling pathways regulating expression of TUBA4B Gene:


SOURCE GeneReport for Unigene cluster for TUBA4B Gene:

genes like me logo Genes that share expression patterns with TUBA4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TUBA4B Gene

Orthologs for TUBA4B Gene

Evolution for TUBA4B Gene

Gene Tree for TUBA4B (if available)
Gene Tree for TUBA4B (if available)

No data available for Orthologs for TUBA4B Gene

Paralogs for TUBA4B Gene

Paralogs for TUBA4B Gene

genes like me logo Genes that share paralogs with TUBA4B: view

Variants for TUBA4B Gene

Sequence variations from dbSNP and Humsavar for TUBA4B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1229763 -- 219,267,716(+) cttgc(C/T)accac intron-variant
rs6707873 -- 219,260,260(+) atgag(A/G)tttta intron-variant
rs7580926 -- 219,271,337(+) TGGTC(A/C/G)AGCCC nc-transcript-variant
rs6716253 -- 219,262,294(+) tgggc(A/G)acaga intron-variant
rs6723299 -- 219,260,482(+) atttc(C/T)gacct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBA4B Gene

Variant ID Type Subtype PubMed ID
esv25352 CNV loss 19812545
esv3594358 CNV loss 21293372
esv3594359 CNV loss 21293372
esv3893555 CNV loss 25118596
nsv1131551 CNV deletion 24896259
nsv508885 CNV insertion 20534489
nsv527936 CNV loss 19592680
nsv584501 CNV loss 21841781
nsv834543 CNV loss 17160897
nsv954842 CNV deletion 24416366
nsv979176 CNV duplication 23825009

Relevant External Links for TUBA4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TUBA4B Gene

Disorders for TUBA4B Gene

Relevant External Links for TUBA4B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TUBA4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUBA4B Gene

Publications for TUBA4B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis- specific expression of two sister genes. (PMID: 3785200) Villasante A. … Cowan N.J. (Mol. Cell. Biol. 1986) 2 3 65
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 65
  4. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PMID: 22360420) Martins-de-Souza D. … Bahn S. (J. Proteome Res. 2012) 3 65
  5. A high-throughput approach for measuring temporal changes in the interactome. (PMID: 22863883) Kristensen A.R. … Foster L.J. (Nat. Methods 2012) 3 65

Products for TUBA4B Gene

Sources for TUBA4B Gene

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