TUBA4B Gene
pseudogene GIFtS: 37
GCID: GC02P220118
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tubulin, alpha 4b (pseudogene)(Previous names: tubulin, alpha 4, tubulin, alpha 4b )
(Previous symbol: TUBA4)
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Aliases
for TUBA4B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Tubulin, Alpha 4b (Pseudogene)1 2 | | Tubulin, Alpha 4b1 | | TUBA41 2 3 | | Putative Tubulin-Like Protein Alpha-4B2 | | FLJ139401 | | Alpha-Tubulin 4B3 | | Tubulin, Alpha 41 | | |
| External Ids: | HGNC: 186371 | Entrez Gene: 800862 | Ensembl: ENSG000002439107 | UniProtKB: Q9H8533 | | ORGUL members: | |
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| NONCODE:n405837 | |
Export aliases for TUBA4B gene to outside databasesPrevious GC identifers: GC02P219827 GC02P211970
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Summaries
for TUBA4B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
 summary
for TUBA4B: Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.
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Genomic Views
for TUBA4B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TUBA4B gene promoter:
E2F-1 AP-1 MyoD E2F-2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TUBA4B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA4B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35TUBA4B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P220118: view genomic region
(about GC identifiers)
Start:
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220,117,965 bp from pter |
End:
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220,136,910 bp from pter |
Size:
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18,946 bases |
Orientation:
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plus strand |
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Proteins
for TUBA4B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: TBA4B_HUMAN, Q9H853 (See
protein sequence)Recommended Name: Putative tubulin-like protein alpha-4B Size: 241 amino acids; 27551 Da
Subcellular location: Cytoplasm, cytoskeleton (Potential)
Caution: Could be the product of a pseudogeneExplore the universe of human proteins at neXtProt for TUBA4B: NX_Q9H853
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H853
TUBA4B Protein expression data from MOPED and PaxDb: --
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TUBA4B for ontologies About GeneDecksing
TUBA4B Antibody Products:
Assay Products for TUBA4B: |
Protein
Domains /
Families
for TUBA4B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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TUBA4B for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H853ProtoNet protein and cluster: Q9H853 UniProtKB/Swiss-Prot: TBA4B_HUMAN, Q9H853Similarity: Belongs to the tubulin family |
Function
for TUBA4B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0005198 | structural molecule activity |
IEA | -- | | GO:0005525 | GTP binding |
IEA | -- |
TUBA4B for ontologies About GeneDecksing
5 GenomeRNAi human phenotypes for TUBA4B:
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Pathways & Interactions
for TUBA4B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table 
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | wtCFTR and deltaF508 traffic / Membrane expression (norm and CF) | | | 2 | Cell cycle_Spindle assembly and chromosome separation | | | 3 | Cytoskeleton remodeling_Reverse signaling by ephrin B | | | 4 | Cell adhesion_Gap junctions | | | 5 | Neurophysiological process Receptor-mediated axon growth repulsion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10  GeneGo (Thomson Reuters) Pathways for TUBA4B (see all 10)
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUBA4B
1 Interacting protein for TUBA4B (Q9H8532, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007018 | microtubule-based movement |
IEA | -- | | GO:0051258 | protein polymerization |
IEA | -- |
TUBA4B for ontologies About GeneDecksing
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Drugs & Compounds
for TUBA4B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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Compounds for TUBA4B available from Tocris Bioscience About this table
Search CenterWatch for drugs/clinical trials and news about TUBA4B
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Transcripts
for TUBA4B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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Unigene Cluster for TUBA4B: Tubulin, alpha 4b (pseudogene) Hs.664469 [show with all ESTs]Unigene Representative Sequence: AK0240024 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000485041 ENST00000473885(uc002vku.3) ENST00000490341(uc002vkv.1)
ENST00000486997
Additional cDNA sequence: AK024002.1 BC121126.1 BC121127.1 NR_003063.1 10 DOTS entries: DT.121017618 DT.100810989 DT.121017490 DT.95258481 DT.91724808 DT.100810985 DT.100810991 DT.118885 DT.121017611 DT.91934824 10 AceView cDNA sequences: AU142757 AK024002 BX279921 NM_025019 AA716340 BG536778 BG483961 BG541833 CD698522 BF337330
GeneLoc Exon Structure
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Expression
for TUBA4B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TUBA4B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATAGTGTGG
About this image
Genevestigator expression for TUBA4B
SOURCE GeneReport for Unigene cluster: Hs.664469
SABiosciences Expression via Pathway-Focused PCR Array including TUBA4B: | Gap Junctions in human mouse rat |
Primer
Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA4B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TUBA4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA4B |
Orthologs
for TUBA4B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for TUBA4B (if available)
TreeFam Gene Tree for TUBA4B (if available) |
Paralogs
for TUBA4B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for TUBA4B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for TUBA4B (220117965 - 220136910 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TUBA4B
1 Indel: 63307 | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for TUBA4B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TUBA4B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TUBA4B gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with TUBA4B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis- specific expression of two sister genes. (PubMed id 3785200)1, 3 Villasante A.... Cowan N.J. (1986)
- Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PubMed id 21110914)1 Grant M.M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743)1 Brehme M....Superti-Furga G. (2009)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
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External Searches for TUBA4B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TUBA4B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing TUBA4B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TUBA4B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for TUBA4B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TUBA4B gene:
Search GeneIP for patents involving TUBA4B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TUBA4B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUBA4B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBA4B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA4B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA4B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA4B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA4B |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for TUBA4B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TUBA4B |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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