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Aliases for TUBA4B Gene

Aliases for TUBA4B Gene

  • Tubulin, Alpha 4b 2 3
  • Tubulin, Alpha 4b (Pseudogene) 2 3
  • Tubulin, Alpha 4 2 3
  • Alpha-Tubulin 4B 3 4
  • TUBA4 3 4
  • Putative Tubulin-Like Protein Alpha-4B 3

External Ids for TUBA4B Gene

Previous HGNC Symbols for TUBA4B Gene

  • TUBA4

Previous GeneCards Identifiers for TUBA4B Gene

  • GC02P219827
  • GC02P220118
  • GC02P211970

Summaries for TUBA4B Gene

GeneCards Summary for TUBA4B Gene

TUBA4B (Tubulin, Alpha 4b) is a Pseudogene. Among its related pathways are EphB-EphrinB Signaling and Development Slit-Robo signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton.

Tocris Summary for TUBA4B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA4B Gene

Genomics for TUBA4B Gene

Regulatory Elements for TUBA4B Gene

Genomic Location for TUBA4B Gene

Start:
219,253,243 bp from pter
End:
219,272,188 bp from pter
Size:
18,946 bases
Orientation:
Plus strand

Genomic View for TUBA4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBA4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA4B Gene

Proteins for TUBA4B Gene

  • Protein details for TUBA4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H853-TBA4B_HUMAN
    Recommended name:
    Putative tubulin-like protein alpha-4B
    Protein Accession:
    Q9H853
    Secondary Accessions:

    Protein attributes for TUBA4B Gene

    Size:
    241 amino acids
    Molecular mass:
    27551 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TUBA4B Gene

Proteomics data for TUBA4B Gene at MOPED

Post-translational modifications for TUBA4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TUBA4B Gene

Domains for TUBA4B Gene

Gene Families for TUBA4B Gene

HGNC:
  • TUB :Tubulins

Protein Domains for TUBA4B Gene

Suggested Antigen Peptide Sequences for TUBA4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H853

UniProtKB/Swiss-Prot:

TBA4B_HUMAN :
  • Q9H853
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA4B: view

Function for TUBA4B Gene

Gene Ontology (GO) - Molecular Function for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBA4B: view
genes like me logo Genes that share phenotypes with TUBA4B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TUBA4B Gene

Localization for TUBA4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA4B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBA4B Gene COMPARTMENTS Subcellular localization image for TUBA4B gene
Compartment Confidence
cytoskeleton 3
cytosol 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with TUBA4B: view

Pathways for TUBA4B Gene

genes like me logo Genes that share pathways with TUBA4B: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Gap Junctions in human,mouse,rat

Interacting Proteins for TUBA4B Gene

Selected Interacting proteins: Q9H853-TBA4B_HUMAN for TUBA4B Gene via MINT I2D

Symbol External ID(s) Details
IKBKG

Gene Ontology (GO) - Biological Process for TUBA4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TUBA4B: view

Compounds for TUBA4B Gene

(5) Tocris Compounds for TUBA4B Gene

Compound Action Cas Number
ABT 751 Inhibitor of microtubule polymerization; antimitotic and antitumor [141430-65-1]
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Harmine Potent and selective Dyrk1A inhibitor [442-51-3]
Vinblastine sulfate Disrupts microtubules [143-67-9]
genes like me logo Genes that share compounds with TUBA4B: view

Transcripts for TUBA4B Gene

mRNA/cDNA for TUBA4B Gene

(10) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUBA4B Gene

Tubulin, alpha 4b (pseudogene):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA4B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TUBA4B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA4B Gene

No ASD Table

Relevant External Links for TUBA4B Gene

GeneLoc Exon Structure for
TUBA4B
ECgene alternative splicing isoforms for
TUBA4B

Expression for TUBA4B Gene

mRNA expression in normal human tissues for TUBA4B Gene

mRNA differential expression in normal tissues according to GTEx for TUBA4B Gene

This gene is overexpressed in Fallopian Tube (12.0), Cervix - Endocervix (5.5), Brain - Hypothalamus (5.0), Brain - Caudate (basal ganglia) (4.9), Lung (4.8), and Kidney - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TUBA4B Gene

SOURCE GeneReport for Unigene cluster for TUBA4B Gene Hs.664469

genes like me logo Genes that share expressions with TUBA4B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TUBA4B Gene

Orthologs for TUBA4B Gene

Evolution for TUBA4B Gene

ENSEMBL:
Gene Tree for TUBA4B (if available)
TreeFam:
Gene Tree for TUBA4B (if available)

No data available for Orthologs for TUBA4B Gene

Paralogs for TUBA4B Gene

genes like me logo Genes that share paralogs with TUBA4B: view

No data available for Paralogs for TUBA4B Gene

Variants for TUBA4B Gene

Sequence variations from dbSNP and Humsavar for TUBA4B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1229763 -- 219,267,716(+) cttgc(C/T)accac intron-variant
rs2891733 -- 219,270,486(-) CCCCC(A/G)ATCAG intron-variant
rs3731892 -- 219,271,629(+) GAAAA(A/C/G)GTATA nc-transcript-variant
rs3896929 -- 219,271,293(+) GCTGG(A/G)ATTCT nc-transcript-variant
rs3896930 -- 219,271,431(+) CTGCC(A/G)CTGCA nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBA4B Gene

Variant ID Type Subtype PubMed ID
nsv834543 CNV Loss 17160897
nsv508885 CNV Insertion 20534489
nsv527936 CNV Loss 19592680
esv25352 CNV Loss 19812545

Relevant External Links for TUBA4B Gene

HapMap Linkage Disequilibrium report
TUBA4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBA4B Gene

Disorders for TUBA4B Gene

No disorders were found for TUBA4B Gene.

No data available for UniProtKB/Swiss-Prot for TUBA4B Gene

Publications for TUBA4B Gene

  1. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis- specific expression of two sister genes. (PMID: 3785200) Villasante A. … Cowan N.J. (Mol. Cell. Biol. 1986) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Charting the molecular network of the drug target Bcr-Abl. (PMID: 19380743) Brehme M. … Superti-Furga G. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
  4. Identification of SUMOylated proteins in neuroblastoma cells after treatment with hydrogen peroxide or ascorbate. (PMID: 21110914) Grant M.M. (BMB Rep 2010) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for TUBA4B Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Gap Junctions in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TUBA4B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA4B
    • Block miRNA regulation of TUBA4B using miScript Target Protectors

    Sources for TUBA4B Gene

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