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TUBA4A Gene

protein-coding   GIFtS: 64
GCID: GC02M220114

Tubulin, Alpha 4a

(Previous names: tubulin, alpha 1 (testis specific), tubulin, alpha 1)
(Previous symbol: TUBA1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Alpha 4a1 2     Tubulin, Alpha 11
TUBA11 2 3 5     H2-ALPHA2
Tubulin, Alpha 1 (Testis Specific)1 2     Tubulin Alpha-4A Chain2
Tubulin Alpha-1 Chain2 3     Alpha-Tubulin 13
Tubulin H2-Alpha2 3     Testis-Specific Alpha-Tubulin3

External Ids:    HGNC: 124071   Entrez Gene: 72772   Ensembl: ENSG000001278247   OMIM: 1911105   UniProtKB: P683663   

Export aliases for TUBA4A gene to outside databases

Previous GC identifers: GC02M219823 GC02M211967


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TUBA4A Gene:
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a
heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin
superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families
are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while
gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta
tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is
a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2013)

GeneCards Summary for TUBA4A Gene:
TUBA4A (tubulin, alpha 4a) is a protein-coding gene. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA4A_HUMAN, P68366
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA4A Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBA4A gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   Sp1   E2F   E2F-2   PPAR-gamma2   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBA4A promoter sequence
   Search Chromatin IP Primers for TUBA4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBA4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q36.1

TUBA4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA4A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M220114:  view genomic region     (about GC identifiers)

Start:
220,114,433 bp from pter      End:
220,142,892 bp from pter
Size:
28,460 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBA4A_HUMAN, P68366 (See protein sequence)
Recommended Name: Tubulin alpha-4A chain  
Size: 448 amino acids; 49924 Da
Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer
diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form
protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule
plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and specialized cells
Miscellaneous: This tubulin does not have a C-terminal tyrosine
Secondary accessions: B3KNQ6 P05215

Explore the universe of human proteins at neXtProt for TUBA4A: NX_P68366

Explore proteomics data for TUBA4A at MOPED

Post-translational modifications: 

  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule
    motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle
    progression or cell differentiation to intracellular trafficking and signaling (By similarity)1
  • Ubiquitination2 at Lys96, Lys163, Lys280, Lys304, Lys311, Lys326, Lys352, Lys370, Lys394, Lys401
  • Glycosylation2 at Asn380
  • Modification sites at PhosphoSitePlus

  • See TUBA4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001265481.1  NP_005991.1  

    ENSEMBL proteins: 
     ENSP00000248437   ENSP00000375938   ENSP00000396212   ENSP00000408194   ENSP00000416992  
     ENSP00000396061   ENSP00000404740  
    Reactome Protein details: P68366

    TUBA4A Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TUBA4A 

     
    antibodies-online proteins for TUBA4A (15 products) 

     
    antibodies-online peptides for TUBA4A

    TUBA4A Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 7):
     IPR002452 Alpha_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry P68366

    ProtoNet protein and cluster: P68366

    UniProtKB/Swiss-Prot: TBA4A_HUMAN, P68366
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBA4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBA4A_HUMAN, P68366
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding IPI16455083
    GO:0005525GTP binding IEA--
         
    Find genes that share ontologies with TUBA4A           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TUBA4A:
     Decreased DCP1a protein expres  Decreased cell number, increas  Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TUBA4A

    miRNA
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    GenScript: all cDNA clones in your preferred vector: TUBA4A (NM_006000)
    Sino Biological Human cDNA Clone for TUBA4A
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBA4A_HUMAN, P68366: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    extracellular4

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005874microtubule IDA--
    GO:0005881cytoplasmic microtubule ----

    Find genes that share ontologies with TUBA4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBA4A About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    4Regulation of PLK1 Activity at G2/M Transition
    Recruitment of mitotic centrosome proteins and complexes0.86
    Regulation of PLK1 Activity at G2/M Transition0.77
    Loss of Nlp from mitotic centrosomes0.86
    G2/M Transition0.70
    Centrosome maturation0.86
    Mitotic G2-G2/M phases0.69
    Loss of proteins required for interphase microtubule organizationfrom the centrosome0.86
    5Protein folding
    Chaperonin-mediated protein folding0.91
    Post-chaperonin tubulin folding pathway0.00
    Protein folding0.91


    Find genes that share SuperPaths with TUBA4A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TUBA4A (see all 11)
        Sertoli-Sertoli Cell Junction Dynamics
    Remodeling of Adherens Junctions
    Molecular Mechanisms of Cancer
    Signaling in Gap Junctions
    Epithelial Adherens Junctions

    Selected GeneGo (Thomson Reuters) Pathways for TUBA4A (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBA4A
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection


    Selected Reactome Pathways for TUBA4A (see all 18)
        Resolution of Sister Chromatid Cohesion
    Prefoldin mediated transfer of substrate to CCT/TriC
    Mitotic Prometaphase
    Recruitment of mitotic centrosome proteins and complexes
    Recruitment of NuMA to mitotic centrosomes


    3 Kegg Pathways  (Kegg details for TUBA4A):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Array including TUBA4A: 
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TUBA4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBA4A (P683661, 2, 3 ENSP000002484374) via UniProtKB, MINT, STRING, and/or I2D (see all 1112) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UCHL5Q9Y5K52, 3, ENSP000003564254MINT-4050722 MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000356425
    PLK1P533502, 3, ENSP000003000934MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000300093
    TCP1P179872, 3, ENSP000003173344MINT-7945693 MINT-7947479 I2D: score=4 STRING: ENSP00000317334
    ACTBP607092, 3, ENSP000003499604MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000349960
    BUB1O436832, 3, ENSP000003025304MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000302530
    PSMC2P359982, 3MINT-4050722 MINT-7945693 MINT-7947479 I2D: score=1 
    PSMC3P179802, 3MINT-4050722 MINT-7945693 MINT-7947479 I2D: score=1 
    PSMC4P436862, 3MINT-4050722 MINT-7945693 MINT-7947479 I2D: score=1 
    PSMC5P621952, 3MINT-4050722 MINT-7945693 MINT-7947479 I2D: score=1 
    RACGAP1Q9H0H52, 3, ENSP000003098714MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000309871
    RBBP5Q152912, 3, ENSP000002645154MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000264515
    ENSG00000258947Q135092, 3MINT-7945693 I2D: score=3 
    GCN1L1Q926162, 3MINT-7945693 MINT-7947479 I2D: score=3 
    HDAC6Q9UBN72, 3, ENSP000003340614MINT-5206963 I2D: score=3 STRING: ENSP00000334061
    TUBB3Q135092, 3MINT-7945693 I2D: score=3 
    DNM1LO004292, 3MINT-7945693 MINT-7947479 I2D: score=2 
    IPO5O004102, 3MINT-7945693 MINT-7947479 I2D: score=2 
    RUVBL2Q9Y2302, 3MINT-7945693 MINT-7947479 I2D: score=2 
    ABCF3Q9NUQ82, 3MINT-7945693 MINT-7947479 I2D: score=1 
    ARCN1P484442, 3MINT-7945693 MINT-7947479 I2D: score=1 
    BTAF1O149812, 3MINT-7945693 MINT-7947479 I2D: score=1 
    CDC16Q130422, 3MINT-7945693 MINT-7947479 I2D: score=1 
    DNAJA1P316892, 3MINT-7945693 MINT-7947479 I2D: score=1 
    EXOC5O004712, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HSP90AA1P079002, 3MINT-7945693 MINT-7947479 I2D: score=1 
    HSPD1P108092, 3MINT-7945693 MINT-7947479 I2D: score=1 
    IPO9Q96P702, 3MINT-7945693 MINT-7947479 I2D: score=1 
    MSH2P432462, 3MINT-7945693 MINT-7947479 I2D: score=1 
    NSFP464592, 3MINT-7945693 MINT-7947479 I2D: score=1 
    RFC2P352502, 3MINT-7945693 MINT-7947479 I2D: score=1 
    SKA1Q96BD82, 3, ENSP000002851164MINT-3391222 I2D: score=1 STRING: ENSP00000285116
    SMAD1Q157972, 3, ENSP000003057694MINT-4298089 I2D: score=1 STRING: ENSP00000305769
    SMC3Q9UQE72, 3MINT-7945693 MINT-7947479 I2D: score=1 
    SRP54P610112, 3MINT-7945693 MINT-7947479 I2D: score=1 
    SRRM2Q9UQ352, 3, ENSP000003017404MINT-7945693 I2D: score=1 STRING: ENSP00000301740
    UBA5Q9GZZ92, 3MINT-7945693 MINT-7947479 I2D: score=1 
    RBM23Q86U062, 3MINT-64810 I2D: score=3 
    SIMC1Q8NDZ22, 3MINT-65004 I2D: score=3 
    IPO7O953732, 3MINT-7947479 I2D: score=2 
    TNPO1Q929732, 3MINT-7947479 I2D: score=2 
    TRIP12Q146692, 3MINT-7945693 I2D: score=2 
    XPO5Q9HAV42, 3MINT-7947479 I2D: score=2 
    BRIX1Q8TDN62, 3MINT-7945693 I2D: score=1 
    CDK3Q005262, 3MINT-7945693 I2D: score=1 
    DDX6P261962, 3MINT-7947479 I2D: score=1 
    DHX8Q145622, 3MINT-7945693 I2D: score=1 
    GAPDHP044062, 3MINT-7947479 I2D: score=1 
    GTPBP4Q9BZE42, 3MINT-7945693 I2D: score=1 
    PRKAG1P546192, 3MINT-7945693 I2D: score=1 
    PSMD4P550362, 3MINT-4050722 I2D: score=1 
    PWP1Q136102, 3MINT-7945693 I2D: score=1 
    RPL12P300502, 3MINT-7945693 I2D: score=1 
    SQSTM1Q135012, 3MINT-7945693 I2D: score=1 
    CLIP1P306221, 2, 3, ENSP000003516654EBI-351772,EBI-2683569 MINT-1789920 MINT-1781370 MINT-1781342 I2D: score=1 STRING: ENSP00000351665
    LTAP013743, ENSP000004034954I2D: score=2 STRING: ENSP00000403495
    CDC5LQ994592, 3, ENSP000003605324MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000360532
    DYNC1H1Q142042, 3, ENSP000003489654MINT-7945693 MINT-7947479 I2D: score=1 STRING: ENSP00000348965
    ENSG00000230279P013743I2D: score=2 
    ENSG00000231408P013743I2D: score=2 
    ENSG00000232421P074372, ENSP000004108294MINT-7945693 MINT-7947479 STRING: ENSP00000410829
    TUBB1Q9H4B72, ENSP000002171334MINT-4050722 MINT-7945693 STRING: ENSP00000217133
    CKAP5Q140082, ENSP000003465664MINT-7945693 MINT-7947479 STRING: ENSP00000346566
    MAD1L1Q9Y6D92, ENSP000003825624MINT-7945693 MINT-7947479 STRING: ENSP00000382562
    BUB1BO605662, ENSP000002875984MINT-7945693 MINT-7947479 STRING: ENSP00000287598
    EXOSC10Q017802, ENSP000003661354MINT-7945693 MINT-7947479 STRING: ENSP00000366135
    ENO2P091042, 3, ENSP000002292774MINT-63433 I2D: score=4 STRING: ENSP00000229277
    ARHGEF2Q929742, ENSP000003153254MINT-7945693 MINT-7947479 STRING: ENSP00000315325
    BUB3O436842, ENSP000003578584MINT-7945693 MINT-7947479 STRING: ENSP00000357858
    CCT7Q998322, ENSP000002580914MINT-7945693 MINT-7947479 STRING: ENSP00000258091
    DYNC1LI2O432372, ENSP000002581984MINT-7945693 MINT-7947479 STRING: ENSP00000258198
    HSPA5P110212MINT-4050722 MINT-7945693 MINT-7947479
    HSPA8P111422MINT-4050722 MINT-7945693 MINT-7947479
    PSMC1P621912MINT-4050722 MINT-7945693 MINT-7947479
    PSMC6P623332MINT-4050722 MINT-7945693 MINT-7947479
    PSMD1Q994602MINT-4050722 MINT-7945693 MINT-7947479
    PSMD11O002312MINT-4050722 MINT-7945693 MINT-7947479
    PSMD12O002322MINT-4050722 MINT-7945693 MINT-7947479
    PSMD13Q9UNM62MINT-4050722 MINT-7945693 MINT-7947479
    PSMD2Q132002MINT-4050722 MINT-7945693 MINT-7947479
    PSMD3O432422MINT-4050722 MINT-7945693 MINT-7947479
    SNW1Q135732, ENSP000002615314MINT-7945693 MINT-7947479 STRING: ENSP00000261531
    TUBB4BP683712, ENSP000003412894MINT-7945693 MINT-7947479 STRING: ENSP00000341289
    MAPRE1Q156913, ENSP000003647214I2D: score=4 STRING: ENSP00000364721
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=3 STRING: ENSP00000363970
    APCP250543, ENSP000002574304I2D: score=2 STRING: ENSP00000257430
    BRCA1P383983, ENSP000003502834I2D: score=2 STRING: ENSP00000350283
    LGALS2P051623, ENSP000002158864I2D: score=2 STRING: ENSP00000215886
    MAP1AP785593, ENSP000003002314I2D: score=2 STRING: ENSP00000300231
    NCALDP616013, ENSP000002209314I2D: score=2 STRING: ENSP00000220931
    RTN4Q9NQC33, ENSP000003378384I2D: score=2 STRING: ENSP00000337838
    STARD13Q9Y3M83, ENSP000003387854I2D: score=2 STRING: ENSP00000338785
    TAOK2Q9UL543, ENSP000003100944I2D: score=2 STRING: ENSP00000310094
    VAV1P154983, ENSP000003022694I2D: score=2 STRING: ENSP00000302269
    ACTG1P632613, ENSP000003315144I2D: score=1 STRING: ENSP00000331514
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    HSPH1Q925983, ENSP000003186874I2D: score=1 STRING: ENSP00000318687
    MAPK3P273613, ENSP000002630254I2D: score=1 STRING: ENSP00000263025
    MAPTP106363, ENSP000003408204I2D: score=1 STRING: ENSP00000340820
    MARK4Q96L343, ENSP000003008434I2D: score=1 STRING: ENSP00000300843
    NCOA6Q146863, ENSP000003518944I2D: score=1 STRING: ENSP00000351894
    PARK2O602603, ENSP000003558654I2D: score=1 STRING: ENSP00000355865
    PPP2R2AP631513, ENSP000003701134I2D: score=1 STRING: ENSP00000370113
    SIAH1Q8IUQ43, ENSP000003491564I2D: score=1 STRING: ENSP00000349156
    SIRT2Q8IXJ63, ENSP000002493964I2D: score=1 STRING: ENSP00000249396
    STXBP1P617643, ENSP000003623994I2D: score=1 STRING: ENSP00000362399
    UBCP0CG483, ENSP000003448184I2D: score=2 STRING: ENSP00000344818
    MYCP011063, ENSP000003672074I2D: score=6 STRING: ENSP00000367207
    B4GALT1P152913, ENSP000003690554I2D: score=2 STRING: ENSP00000369055
    CALB2P226763, ENSP000003075084I2D: score=2 STRING: ENSP00000307508
    EPB41P111713, ENSP000002901004I2D: score=2 STRING: ENSP00000290100
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    GPHNQ9NQX33, ENSP000003030194I2D: score=1 STRING: ENSP00000303019
    RAB8BQ929303, ENSP000003127344I2D: score=1 STRING: ENSP00000312734
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    SYKP434053, ENSP000003648984I2D: score=3 STRING: ENSP00000364898
    TBCBQ994263, ENSP000002218554I2D: score=1 STRING: ENSP00000221855
    TBCEQ158133, ENSP000003555604I2D: score=5 STRING: ENSP00000355560
    VDAC1P217963, ENSP000002653334I2D: score=2 STRING: ENSP00000265333
    GRM7Q148313, ENSP000003503484I2D: score=1 STRING: ENSP00000350348
    PFDN4Q9NQP43, ENSP000003604734I2D: score=2 STRING: ENSP00000360473
    ZAP70P434033, ENSP000002649724I2D: score=2 STRING: ENSP00000264972
    ARHGAP1Q079603, ENSP000003104914I2D: score=2 STRING: ENSP00000310491
    ASCL2Q999293, ENSP000003322934I2D: score=1 STRING: ENSP00000332293
    BTKQ061873, ENSP000003081764I2D: score=1 STRING: ENSP00000308176
    MAP1LC3BQ9GZQ83, ENSP000002686074I2D: score=2 STRING: ENSP00000268607
    EGFRP005333, ENSP000002754934I2D: score=3 STRING: ENSP00000275493
    CDC40O605083, ENSP000003043704I2D: score=1 STRING: ENSP00000304370
    CLUHO751533, ENSP000003888724I2D: score=1 STRING: ENSP00000388872
    ERCC2P180743, ENSP000003758094I2D: score=3 STRING: ENSP00000375809
    SHC1P293532, ENSP000004013034MINT-7947479 STRING: ENSP00000401303
    GRIN1Q055863, ENSP000003606164I2D: score=1 STRING: ENSP00000360616
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    KIFC3Q9BVG83, ENSP000003689764I2D: score=1 STRING: ENSP00000368976
    ACTN2P356093, ENSP000003555374I2D: score=1 STRING: ENSP00000355537
    GNAI2P048993, ENSP000003129994I2D: score=2 STRING: ENSP00000312999
    ATG4CQ96DT63, ENSP000003221594I2D: score=1 STRING: ENSP00000322159
    ATG4BQ9Y4P13, ENSP000003842594I2D: score=5 STRING: ENSP00000384259
    ABCF1Q8NE712MINT-7945693 MINT-7947479
    ACTL6AO960192MINT-7945693 MINT-7947479
    ACTR1AP611632MINT-7945693 MINT-7947479
    ACTR2P611602MINT-7945693 MINT-7947479
    ADNPQ9H2P02MINT-7945693 MINT-7947479
    AHNAKQ096662MINT-7945693 MINT-7947479
    ANAPC1Q9H1A42MINT-7945693 MINT-7947479
    ANLNQ9NQW62MINT-7945693 MINT-7947479
    AP1B1Q105672MINT-7945693 MINT-7947479
    ARHGEF1Q928882MINT-7945693 MINT-7947479
    ARID1AO144972MINT-7945693 MINT-7947479
    AURKBQ96GD42MINT-7945693 MINT-7947479
    BAZ1AQ9NRL22MINT-7945693 MINT-7947479
    BCAS2O759342MINT-7945693 MINT-7947479
    BCLAF1Q9NYF82MINT-7945693 MINT-7947479
    BRD8Q9H0E92MINT-7945693 MINT-7947479
    BZW1Q7L1Q62MINT-7945693 MINT-7947479
    CAPGP401212MINT-7945693 MINT-7947479
    CAPZA1P529072MINT-7945693 MINT-7947479
    CCNB1P146352MINT-7945693 MINT-7947479
    CCT2P783712MINT-7945693 MINT-7947479
    CCT3P493682MINT-7945693 MINT-7947479
    CCT4P509912MINT-7945693 MINT-7947479
    CCT5P486432MINT-7945693 MINT-7947479
    CCT6AP402272MINT-7945693 MINT-7947479
    CCT8P509902MINT-7945693 MINT-7947479
    CDC23Q9UJX22MINT-7945693 MINT-7947479
    CDC27P302602MINT-7945693 MINT-7947479
    CDC73Q6P1J92MINT-7945693 MINT-7947479
    CDK9P507502MINT-7945693 MINT-7947479
    CDKN2AIPQ9NXV62MINT-7945693 MINT-7947479
    CHD1LQ86WJ12MINT-7945693 MINT-7947479
    CHD8Q9HCK82MINT-7945693 MINT-7947479
    CHEK1O147572MINT-7945693 MINT-7947479
    CLASP1Q7Z4602, ENSP000002637104MINT-7947479 STRING: ENSP00000263710
    COPAP536212MINT-7945693 MINT-7947479
    COPB1P536182MINT-7945693 MINT-7947479
    COPB2P356062MINT-7945693 MINT-7947479
    COPG1Q9Y6782MINT-7945693 MINT-7947479
    COPG2Q9UBF22MINT-7945693 MINT-7947479
    COPS5Q929052MINT-7945693 MINT-7947479
    CPSF2Q9P2I02MINT-7945693 MINT-7947479
    CPSF3Q9UKF62MINT-7945693 MINT-7947479
    CPSF7Q8N6842MINT-7945693 MINT-7947479
    CSE1LP550602MINT-7945693 MINT-7947479
    CSTF3Q129962MINT-7945693 MINT-7947479
    CUL1Q136162MINT-7945693 MINT-7947479
    DCTN2Q135612MINT-7945693 MINT-7947479
    DDX17Q928412MINT-7945693 MINT-7947479
    DDX19AQ9NUU72MINT-7945693 MINT-7947479
    DDX19BQ9UMR22MINT-7945693 MINT-7947479
    DDX39AO001482MINT-7945693 MINT-7947479
    DDX39BQ138382MINT-7945693 MINT-7947479
    DDX3XO005712MINT-7945693 MINT-7947479
    DDX41Q9UJV92MINT-7945693 MINT-7947479
    DDX42Q86XP32MINT-7945693 MINT-7947479
    DDX5P178442MINT-7945693 MINT-7947479
    DEPDC7Q96QD52MINT-7945693 MINT-7947479
    DFNA5O604432MINT-7945693 MINT-7947479
    DIAPH1O606102MINT-7945693 MINT-7947479
    DIDO1Q9BTC02MINT-7945693 MINT-7947479
    DMAP1Q9NPF52MINT-7945693 MINT-7947479
    DNM2P505702MINT-7945693 MINT-7947479
    DRG1Q9Y2952MINT-7945693 MINT-7947479
    DSPP159242MINT-7945693 MINT-7947479
    DYNC1LI1Q9Y6G92, ENSP000002731304MINT-7947479 STRING: ENSP00000273130
    EEF1A1P681042MINT-7945693 MINT-7947479
    EFTUD2Q150292MINT-7945693 MINT-7947479
    EHD1Q9H4M92MINT-7945693 MINT-7947479
    EHD4Q9H2232MINT-7945693 MINT-7947479
    EIF2S3P410912MINT-7945693 MINT-7947479
    EIF3GO758212MINT-7945693 MINT-7947479
    EIF3IQ133472MINT-7945693 MINT-7947479
    EIF4A1P608422MINT-7945693 MINT-7947479
    EIF4A3P389192MINT-7945693 MINT-7947479
    EIF4G2P783442MINT-7945693 MINT-7947479
    EIF5BO608412MINT-7945693 MINT-7947479
    ELAVL1Q157172MINT-7945693 MINT-7947479
    ENAHQ8N8S72MINT-7945693 MINT-7947479
    ENSG00000183311P074372MINT-7945693 MINT-7947479
    ENSG00000206490Q8NE712MINT-7945693 MINT-7947479
    ENSG00000215425Q138382MINT-7945693 MINT-7947479
    ENSG00000224156P074372MINT-7945693 MINT-7947479
    ENSG00000225073Q138382MINT-7945693 MINT-7947479
    ENSG00000225859Q138382MINT-7945693 MINT-7947479
    ENSG00000225989Q8NE712MINT-7945693 MINT-7947479
    ENSG00000227739P074372MINT-7945693 MINT-7947479
    ENSG00000229496Q138382MINT-7945693 MINT-7947479
    ENSG00000229684P074372MINT-7945693 MINT-7947479
    ENSG00000230624Q138382MINT-7945693 MINT-7947479
    ENSG00000231129Q8NE712MINT-7945693 MINT-7947479
    ENSG00000232169Q8NE712MINT-7945693 MINT-7947479
    ENSG00000232575P074372MINT-7945693 MINT-7947479
    ENSG00000235067P074372MINT-7945693 MINT-7947479
    ENSG00000235439Q138382MINT-7945693 MINT-7947479
    ENSG00000236149Q8NE712MINT-7945693 MINT-7947479
    ENSG00000236342Q8NE712MINT-7945693 MINT-7947479
    EPPK1P581072MINT-7945693 MINT-7947479
    EPS8L2Q9H6S32MINT-7945693 MINT-7947479
    ETF1P624952MINT-7945693 MINT-7947479
    ETV6P412122MINT-7945693 MINT-7947479
    EXOC2Q96KP12MINT-7945693 MINT-7947479
    EXOC4Q96A652MINT-7945693 MINT-7947479
    EXOC7Q9UPT52MINT-7945693 MINT-7947479
    FAM129BQ96TA12MINT-7945693 MINT-7947479
    FANCIQ9NVI12MINT-7945693 MINT-7947479
    FASNP493272MINT-7945693 MINT-7947479
    FEN1P397482MINT-7945693 MINT-7947479
    FERMT1Q9BQL62MINT-7945693 MINT-7947479
    FHOD1Q9Y6132MINT-7945693 MINT-7947479
    FUSP356372MINT-7945693 MINT-7947479
    GATAD2AQ86YP42MINT-7945693 MINT-7947479
    GEMIN4P576782MINT-7945693 MINT-7947479
    GTF2IP783472MINT-7945693 MINT-7947479
    GTF3C2Q8WUA42MINT-7945693 MINT-7947479
    GULP1Q9UBP92MINT-7945693 MINT-7947479
    HBS1LQ9Y4502MINT-7945693 MINT-7947479
    HDAC1Q135472MINT-7945693 MINT-7947479
    HDAC2Q927692MINT-7945693 MINT-7947479
    HDLBPQ003412MINT-7945693 MINT-7947479
    HELLSQ9NRZ92MINT-7945693 MINT-7947479
    HIP1RO751462MINT-7945693 MINT-7947479
    HIRAP541982MINT-7945693 MINT-7947479
    HLTFQ145272MINT-7945693 MINT-7947479
    HNRNPA2B1P226262MINT-7945693 MINT-7947479
    HNRNPCP079102MINT-7945693 MINT-7947479
    HNRNPFP525972MINT-7945693 MINT-7947479
    HNRNPH1P319432MINT-7945693 MINT-7947479
    HNRNPKP619782MINT-7945693 MINT-7947479
    HNRNPMP522722MINT-7945693 MINT-7947479
    HNRNPUQ008392MINT-7945693 MINT-7947479
    HSP90AB1P082382MINT-7945693 MINT-7947479
    HSP90B1P146252MINT-7945693 MINT-7947479
    HSPA12AO433012MINT-7945693 MINT-7947479
    HSPB1P047922MINT-7945693 MINT-7947479
    ILF2Q129052MINT-7945693 MINT-7947479
    INTS1Q8N2012MINT-7945693 MINT-7947479
    INTS3Q68E012MINT-7945693 MINT-7947479
    IQGAP1P469402MINT-7945693 MINT-7947479
    KDM1AO603412MINT-7945693 MINT-7947479
    KHDRBS1Q076662MINT-7945693 MINT-7947479
    KIF11P527322MINT-7945693 MINT-7947479
    KIF21AQ7Z4S62MINT-7945693 MINT-7947479
    KIF2CQ996612MINT-7945693 MINT-7947479
    KIF4AO952392MINT-7945693 MINT-7947479
    KPNA2P522922MINT-7945693 MINT-7947479
    KPNB1Q149742MINT-7945693 MINT-7947479
    LIMS1P480592MINT-7945693 MINT-7947479
    LMNAP025452MINT-7945693 MINT-7947479
    LRRC40Q9H9A62MINT-7945693 MINT-7947479
    LRWD1Q9UFC02MINT-7945693 MINT-7947479
    MAP2K7O147332MINT-7945693 MINT-7947479
    MATR3P432432MINT-7945693 MINT-7947479
    MDN1Q9NU222MINT-7945693 MINT-7947479
    MED4Q9NPJ62MINT-7945693 MINT-7947479
    MRE11AP499592MINT-7945693 MINT-7947479
    MSH6P527012MINT-7945693 MINT-7947479
    MTA2O947762MINT-7945693 MINT-7947479
    MVPQ147642MINT-7945693 MINT-7947479
    MYH9P355792MINT-7945693 MINT-7947479
    MYO15BQ96JP22MINT-7945693 MINT-7947479
    NACC1Q96RE72MINT-7945693 MINT-7947479
    NBNO609342MINT-7945693 MINT-7947479
    NCAPD2Q150212MINT-7945693 MINT-7947479
    NCAPHQ150032MINT-7945693 MINT-7947479
    NCOR1O753762MINT-7945693 MINT-7947479
    NDC80O147772MINT-7945693 MINT-7947479
    NELFBQ8WX922MINT-7945693 MINT-7947479
    NIPBLQ6KC792MINT-7945693 MINT-7947479
    NONOQ152332MINT-7945693 MINT-7947479
    NSUN5Q96P112MINT-7945693 MINT-7947479
    NUDCQ9Y2662MINT-7945693 MINT-7947479
    NUF2Q9BZD42MINT-7945693 MINT-7947479
    NUP155O756942MINT-7945693 MINT-7947479
    ORC2Q134162MINT-7945693 MINT-7947479
    ORC3Q9UBD52MINT-7945693 MINT-7947479
    OXSR1O957472MINT-7945693 MINT-7947479
    PAK4O960132MINT-7945693 MINT-7947479
    PARVAQ9NVD72MINT-7945693 MINT-7947479
    PARVBQ9HBI12MINT-7945693 MINT-7947479
    PCBP2Q153662MINT-7945693 MINT-7947479
    PDLIM7Q9NR122MINT-7945693 MINT-7947479
    PFKMP082372MINT-7945693 MINT-7947479
    PFKPQ018132MINT-7945693 MINT-7947479
    PHGDHO431752MINT-7945693 MINT-7947479
    PICALMQ134922MINT-7945693 MINT-7947479
    PKN2Q165132MINT-7945693 MINT-7947479
    PLECQ151492MINT-7945693 MINT-7947479
    PLRG1O436602MINT-7945693 MINT-7947479
    PNNQ9H3072MINT-7945693 MINT-7947479
    POLD1P283402MINT-7945693 MINT-7947479
    POLR1CO151602MINT-7945693 MINT-7947479
    PPP1CAP621362MINT-7945693 MINT-7947479
    PPP2R1AP301532MINT-7945693 MINT-7947479
    PRKDCP785272MINT-7945693 MINT-7947479
    PRPF19Q9UMS42MINT-7945693 MINT-7947479
    PRPF6O949062MINT-7945693 MINT-7947479
    PRPF8Q6P2Q92MINT-7945693 MINT-7947479
    PTBP1P265992MINT-7945693 MINT-7947479
    PUM1Q146712, ENSP000003917234MINT-7947479 STRING: ENSP00000391723
    PUM2Q8TB722, ENSP000003381734MINT-7945693 STRING: ENSP00000338173
    RAD18Q9NS912MINT-7945693 MINT-7947479
    RAD50Q928782MINT-7945693 MINT-7947479
    RALYQ9UKM92MINT-7945693 MINT-7947479
    RANBP2P497922MINT-7945693 MINT-7947479
    RANGAP1P460602MINT-7945693 MINT-7947479
    RBBP7Q165762MINT-7945693 MINT-7947479
    RBM17Q96I252MINT-7945693 MINT-7947479
    RBM39Q144982MINT-7945693 MINT-7947479
    RBM4Q9BWF32MINT-7945693 MINT-7947479
    RBM45Q8IUH32MINT-7945693 MINT-7947479
    RBMXP381592MINT-7945693 MINT-7947479
    RCOR1Q9UKL02MINT-7945693 MINT-7947479
    RFC3P409382MINT-7945693 MINT-7947479
    RFC4P352492MINT-7945693 MINT-7947479
    RFC5P409372MINT-7945693 MINT-7947479
    RIF1Q5UIP02MINT-7945693 MINT-7947479
    ROCK2O751162MINT-7945693 MINT-7947479
    RPL13P263732MINT-7945693 MINT-7947479
    RPL22P352682MINT-7945693 MINT-7947479
    RPL31P628992MINT-7945693 MINT-7947479
    RPLP0P053882MINT-7945693 MINT-7947479
    RPS6KA4O756762MINT-7945693 MINT-7947479
    RPS6KB2Q9UBS02MINT-7945693 MINT-7947479
    RTCBQ9Y3I02MINT-7945693 MINT-7947479
    RUVBL1Q9Y2652MINT-7945693 MINT-7947479
    SART1O432902MINT-7945693 MINT-7947479
    SCYL2Q6P3W72MINT-7945693 MINT-7947479
    SEH1LQ96EE32MINT-7945693 MINT-7947479
    SEPT9Q9UHD82MINT-7945693 MINT-7947479
    SETXQ7Z3332MINT-7945693 MINT-7947479
    SF3A1Q154592MINT-7945693 MINT-7947479
    SF3A3Q128742MINT-7945693 MINT-7947479
    SF3B1O755332MINT-7945693 MINT-7947479
    SF3B2Q134352MINT-7945693 MINT-7947479
    SF3B3Q153932MINT-7945693 MINT-7947479
    SF3B6Q9Y3B42MINT-7945693 MINT-7947479
    SFPQP232462MINT-7945693 MINT-7947479
    SHROOM3Q8TF722MINT-7945693 MINT-7947479
    SMARCA5O602642MINT-7945693 MINT-7947479
    SMARCAD1Q9H4L72MINT-7945693 MINT-7947479
    SMARCB1Q128242MINT-7945693 MINT-7947479
    SMARCC1Q929222MINT-7945693 MINT-7947479
    SMARCC2Q8TAQ22MINT-7945693 MINT-7947479
    SMARCD1Q96GM52MINT-7945693 MINT-7947479
    SMARCE1Q969G32MINT-7945693 MINT-7947479
    SMC1AQ146832MINT-7945693 MINT-7947479
    SMC2O953472MINT-7945693 MINT-7947479
    SMC4Q9NTJ32MINT-7945693 MINT-7947479
    SMCHD1A6NHR92MINT-7945693 MINT-7947479
    SMN1Q166372MINT-7945693 MINT-7947479
    SMN2Q166372MINT-7945693 MINT-7947479
    SNRNP200O756432MINT-7945693 MINT-7947479
    SNRNP40Q96DI72MINT-7945693 MINT-7947479
    SNRNP70P086212MINT-7945693 MINT-7947479
    SNRPD3P623182MINT-7945693 MINT-7947479
    SPATA5Q8NB902MINT-7945693 MINT-7947479
    SPTAN1Q138132MINT-7945693 MINT-7947479
    SPTBN1Q010822MINT-7945693 MINT-7947479
    SRP68Q9UHB92MINT-7945693 MINT-7947479
    SRP72O760942MINT-7945693 MINT-7947479
    SRRM1Q8IYB32MINT-7945693 MINT-7947479
    SRSF1Q079552MINT-7945693 MINT-7947479
    SRSF7Q166292MINT-7945693 MINT-7947479
    SUGT1Q9Y2Z02MINT-7945693 MINT-7947479
    SYMPKQ927972MINT-7945693 MINT-7947479
    TARDBPQ131482MINT-7945693 MINT-7947479
    TBL1XR1Q9BZK72MINT-7945693 MINT-7947479
    THRAP3Q9Y2W12MINT-7945693 MINT-7947479
    TIAL1Q010852MINT-7945693 MINT-7947479
    TLN1Q9Y4902MINT-7945693 MINT-7947479
    TMPOP421662MINT-7945693 MINT-7947479
    TRAP1Q129312MINT-7945693 MINT-7947479
    TRIM28Q132632MINT-7945693 MINT-7947479
    TRIP13Q156452MINT-7945693 MINT-7947479
    TRUB1Q8WWH52MINT-7945693 MINT-7947479
    TSG101Q998162MINT-7945693 MINT-7947479
    TUBBP074372MINT-7945693 MINT-7947479
    TUBG1P232582MINT-7945693 MINT-7947479
    TUBGCP2Q9BSJ22MINT-7945693 MINT-7947479
    TUBGCP3Q96CW52MINT-7945693 MINT-7947479
    TWF1Q127922MINT-7945693 MINT-7947479
    U2AF1Q010812MINT-7945693 MINT-7947479
    U2AF2P263682MINT-7945693 MINT-7947479
    U2SURPO150422MINT-7945693 MINT-7947479
    UBE2MP610812MINT-7945693 MINT-7947479
    UBE2NP610882MINT-7945693 MINT-7947479
    UBL4AP114412MINT-7945693 MINT-7947479
    UNC45AQ9H3U12MINT-7945693 MINT-7947479
    UPF1Q929002MINT-7945693 MINT-7947479
    UPF2Q9HAU52MINT-7945693 MINT-7947479
    USP39Q53GS92MINT-7945693 MINT-7947479
    VIMP086702MINT-7945693 MINT-7947479
    VPS33BQ9H2672MINT-7945693 MINT-7947479
    WDR18Q9BV382MINT-7945693 MINT-7947479
    WDR33Q9C0J82MINT-7945693 MINT-7947479
    XRN2Q9H0D62MINT-7945693 MINT-7947479
    ZNF638Q149662MINT-7945693 MINT-7947479
    CBSP355203I2D: score=3 
    MMS19Q96T763I2D: score=3 
    ACSS1Q9NUB13I2D: score=2 
    AHSA1O954333I2D: score=2 
    ARFGEF1Q9Y6D63I2D: score=2 
    ATG3Q9NT623I2D: score=2 
    BCAR1P569453I2D: score=2 
    C4orf17Q53FE43I2D: score=2 
    CTPS1P178123I2D: score=2 
    GABARAPO951663I2D: score=2 
    GABARAPL1Q9H0R83I2D: score=2 
    GNB2L1P632443I2D: score=2 
    IDH3AP502133I2D: score=2 
    KIAA0368Q5VYK33I2D: score=2 
    MAGED1Q9Y5V33I2D: score=2 
    MAT1AQ002663I2D: score=2 
    ME1P481633I2D: score=2 
    NARSO437763I2D: score=2 
    NIP7Q9Y2213I2D: score=2 
    PMM2O153053I2D: score=2 
    RPSAP088653I2D: score=2 
    S100A8P051093I2D: score=2 
    SPTLC1O152693I2D: score=2 
    SPTLC2O152703I2D: score=2 
    TECRQ9NZ013I2D: score=2 
    TM4SF1P304083I2D: score=2 
    TNPO3Q9Y5L03I2D: score=2 
    VBP1P617583I2D: score=2 
    VPS13AQ96RL73I2D: score=2 
    XPO1O149803I2D: score=2 
    ACACBO007633I2D: score=1 
    ACO2Q997983I2D: score=1 
    ALG12Q9BV103I2D: score=1 
    AMBRA1Q9C0C73I2D: score=1 
    ANAPC10Q9UM133I2D: score=1 
    AP1G1O437473I2D: score=1 
    ARG1P050893I2D: score=1 
    ARRB1P494073I2D: score=1 
    ARRB2P321213I2D: score=1 
    ATAD1Q8NBU53I2D: score=1 
    ATG10Q9H0Y03I2D: score=1 
    ATG101Q9BSB43I2D: score=1 
    ATG12O948173I2D: score=1 
    ATG13O751433I2D: score=1 
    ATG14Q6ZNE53I2D: score=1 
    ATG16L1Q676U53I2D: score=1 
    ATG2AQ2TAZ03I2D: score=1 
    ATG5Q9H1Y03I2D: score=1 
    ATG7O953523I2D: score=1 
    ATP2C1P981943I2D: score=1 
    ATP5BP065763I2D: score=1 
    ATP5C1P365423I2D: score=1 
    ATP6V0A1Q930503I2D: score=1 
    BECN1Q144573I2D: score=1 
    BOP1Q141373I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    CEBPZQ037013I2D: score=1 
    CLN3Q132863I2D: score=1 
    CLTCQ006103I2D: score=1 
    CRLS1Q9UJA23I2D: score=1 
    CRY2Q49AN03I2D: score=1 
    CTNNB1P352223I2D: score=1 
    DDA1Q9BW613I2D: score=1 
    DDIT3P356383I2D: score=1 
    DDX18Q9NVP13I2D: score=1 
    DDX24Q9GZR73I2D: score=1 
    DDX49Q9Y6V73I2D: score=1 
    DDX51Q8N8A63I2D: score=1 
    DDX55Q8NHQ93I2D: score=1 
    DDX56Q9NY933I2D: score=1 
    DHDDSQ86SQ93I2D: score=1 
    DLATP105153I2D: score=1 
    DLG4P783523I2D: score=1 
    DPM1O607623I2D: score=1 
    DPYSL2Q165553I2D: score=1 
    E2F1Q010943I2D: score=1 
    EIF2B2P497703I2D: score=1 
    EIF3AQ141523I2D: score=1 
    EVI5LQ96CN43I2D: score=1 
    EXOC6BQ9Y2D43I2D: score=1 
    FA2HQ7L5A83I2D: score=1 
    FOXO3O435243I2D: score=1 
    FYCO1Q9BQS83I2D: score=1 
    GABARAPL2P605203I2D: score=1 
    GBASO753233I2D: score=1 
    GCLCP485063I2D: score=1 
    GOSR1O952493I2D: score=1 
    GZMMP511243I2D: score=1 
    HCCSP537013I2D: score=1 
    HEATR1Q9H5833I2D: score=1 
    HIF1AQ166653I2D: score=1 
    HMGCRP040353I2D: score=1 
    IL7RP168713I2D: score=1 
    KAT2AQ928303I2D: score=1 
    KAT5Q929933I2D: score=1 
    KBTBD7Q8WVZ93I2D: score=1 
    KDELR3O437313I2D: score=1 
    KLHDC10Q6PID83I2D: score=1 
    LPIN3Q9BQK83I2D: score=1 
    MAP1LC3CQ9BXW43I2D: score=1 
    MARSP561923I2D: score=1 
    MCM4P339913I2D: score=1 
    MCM5P339923I2D: score=1 
    MCM6Q145663I2D: score=1 
    MLST8Q9BVC43I2D: score=1 
    MNAT1P519483I2D: score=1 
    MSMO1Q158003I2D: score=1 
    MYO1EQ129653I2D: score=1 
    NEK9Q8TD193I2D: score=1 
    NHP2L1P557693I2D: score=1 
    NIF3L1Q9GZT83I2D: score=1 
    NOC2LQ9Y3T93I2D: score=1 
    NRBF2Q96F243I2D: score=1 
    NSMAFQ926363I2D: score=1 
    PAFAH1B1P430343I2D: score=1 
    PDCD11Q146903I2D: score=1 
    PDPK1O155303I2D: score=1 
    PES1O005413I2D: score=1 
    PFDN5Q994713I2D: score=1 
    PHBP352323I2D: score=1 
    PHB2Q996233I2D: score=1 
    PIGGQ5H8A43I2D: score=1 
    PIK3C2AO004433I2D: score=1 
    PIK3C3Q8NEB93I2D: score=1 
    PIK3CGP487363I2D: score=1 
    PKLRP306133I2D: score=1 
    POLR1AO956023I2D: score=1 
    PRIM2P496433I2D: score=1 
    PRKAA1Q131313I2D: score=1 
    PRKAA2P546463I2D: score=1 
    PRKAB1Q9Y4783I2D: score=1 
    PRKAB2O437413I2D: score=1 
    PRKAG2Q9UGJ03I2D: score=1 
    PSMD14O004873I2D: score=1 
    PYCRLQ53H963I2D: score=1 
    RAB24Q969Q53I2D: score=1 
    RABGAP1Q9Y3P93I2D: score=1 
    RAD23BP547273I2D: score=1 
    RAP1BP612243I2D: score=1 
    RASSF5Q8WWW03I2D: score=1 
    RB1CC1Q8TDY23I2D: score=1 
    RBM19Q9Y4C83I2D: score=1 
    RBM28Q9NW133I2D: score=1 
    RCC1P187543I2D: score=1 
    RHOT1Q8IXI23I2D: score=1 
    RPL23P628293I2D: score=1 
    RPN1P048433I2D: score=1 
    RQCD1Q926003I2D: score=1 
    RRP12Q5JTH93I2D: score=1 
    SCDO007673I2D: score=1 
    SEC24BO954873I2D: score=1 
    SFXN5Q8TD223I2D: score=1 
    SH3GLB1Q9Y3713I2D: score=1 
    SH3GLB2Q9NR463I2D: score=1 
    SLC25A1P530073I2D: score=1 
    SLC25A29Q8N8R33I2D: score=1 
    SLC25A3Q003253I2D: score=1 
    SLC25A37Q9NYZ23I2D: score=1 
    SLC25A6P122363I2D: score=1 
    SLC30A10Q6XR723I2D: score=1 
    SLC35F5Q8WV833I2D: score=1 
    SLC47A1Q96FL83I2D: score=1 
    SLMO2Q9Y3B13I2D: score=1 
    SMAD2Q157963I2D: score=1 
    STK11Q158313I2D: score=1 
    STK3Q131883I2D: score=1 
    STK4Q130433I2D: score=1 
    SURF4O152603I2D: score=1 
    TECPR1Q7Z6L13I2D: score=1 
    TMED10P497553I2D: score=1 
    TMED2Q153633I2D: score=1 
    TOMM70AO948263I2D: score=1 
    TRAF2Q129333I2D: score=1 
    TRAPPC2P0DI813I2D: score=1 
    TRAPPC2P1P0DI823I2D: score=1 
    TRAPPC3O436173I2D: score=1 
    TTC27Q6P3X33I2D: score=1 
    UBA1P223143I2D: score=1 
    ULK1O753853I2D: score=1 
    ULK2Q8IYT83I2D: score=1 
    UTP15Q8TED03I2D: score=1 
    UTP20O756913I2D: score=1 
    UVRAGQ9P2Y53I2D: score=1 
    VDAC3Q9Y2773I2D: score=1 
    WDR45Q9Y4843I2D: score=1 
    WDR76Q9H9673I2D: score=1 
    WDR82Q6UXN93I2D: score=1 
    WIPI1Q5MNZ93I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    YKT6O154983I2D: score=1 
    ACIN1Q9UKV32MINT-7945693
    ADRM1Q161862MINT-4050722
    AKAP8O438232MINT-7947479
    ANAPC2Q9UJX62MINT-7947479
    ANAPC7Q9UJX32MINT-7947479
    ANXA11P509952MINT-7947479
    AP3B1O002032MINT-7945693
    APBB1IPQ7Z5R62MINT-7945693
    API5Q9BZZ52MINT-7945693
    AQRO603062MINT-7945693
    ARAP1Q96P482MINT-7945693
    ARF4P180852MINT-7945693
    ARF5P840852MINT-7945693
    ARFGEF2Q9Y6D52MINT-7945693
    ARGLU1Q9NWB62MINT-7947479
    ASUNQ9NVM92MINT-7945693
    ATMQ133152MINT-7945693
    ATRQ135352MINT-7945693
    ATRXP461002MINT-7945693
    AURKAO149652MINT-7945693
    BABAM1Q9NWV82MINT-7945693
    BCL7CQ8WUZ02MINT-7945693
    BIDP559572MINT-7947479
    BLMP541322MINT-7945693
    BRD2P254402MINT-7947479
    BRD4O608852MINT-7947479
    BRD7Q9NPI12MINT-7947479
    BZW2Q9Y6E22MINT-7945693
    C7orf13Q8NI282MINT-7947479
    C7orf55-LUC7L2Q9Y3832MINT-7945693
    CAND1Q86VP62MINT-7945693
    CARD10Q9BWT72MINT-7947479
    CASC5Q8NG312MINT-7947479
    CCNT1O605632MINT-7945693
    CDC20Q128342MINT-7947479
    CDK1P064932MINT-7945693
    CDK12Q9NYV42MINT-7945693
    CHD3Q128732MINT-7945693
    CHD4Q148392MINT-7945693
    CHD7Q9P2D12MINT-7945693
    CLINT1Q146772MINT-7947479
    CLP1Q929892MINT-7945693
    CNOT10Q9H9A52MINT-7947479
    CNOT3O751752MINT-7947479
    COPS3Q9UNS22MINT-7945693
    COPS6Q7L5N12MINT-7945693
    CPNE3O751312MINT-7945693
    CPSF1Q105702MINT-7945693
    CPSF4O956392MINT-7945693
    CSKP412402MINT-7945693
    CTNND1O607162MINT-7947479
    CTTNQ142472MINT-7945693
    CWC15Q9P0132MINT-7947479
    DCTN1Q142032MINT-7945693
    DDB1Q165312MINT-7947479
    DDX1Q924992MINT-7945693
    DDX21Q9NR302MINT-7945693
    DDX23Q9BUQ82MINT-7945693
    DDX46Q7L0142MINT-7945693
    DDX47Q9H0S42MINT-7947479
    DHX9Q082112MINT-7945693
    DIAPH3Q9NSV42MINT-7945693
    DNAJC13O751652MINT-7945693
    DOCK1Q141852MINT-7945693
    DOCK2Q926082MINT-7945693
    DOCK5Q9H7D02MINT-7947479
    DOCK8Q8NF502MINT-7947479
    DPF2Q927852MINT-7945693
    DTYMKP239192MINT-7947479
    EBNA1BP2Q998482MINT-7945693
    ECT2Q9H8V32MINT-7947479
    EDC4Q6P2E92MINT-7947479
    EEFSECP577722MINT-7945693
    EHMT1Q9H9B12MINT-7947479
    EIF2B4Q9UI102MINT-7947479
    EIF2DP412142MINT-7947479
    EIF2S1P051982MINT-7945693
    EIF2S2P200422MINT-7945693
    EIF3BP558842MINT-7947479
    EIF3EP602282MINT-7945693
    EIF3HO153722MINT-7945693
    EIF3LQ9Y2622MINT-7945693
    EIF4A2Q142402MINT-7947479
    ELF2Q157232MINT-7947479
    ENSG00000096150P622692MINT-7945693
    ENSG00000206287Q065872MINT-7945693
    ENSG00000206289P287022MINT-7947479
    ENSG00000212866P081072MINT-4050722
    ENSG00000215077P254402MINT-7947479
    ENSG00000215328P081072MINT-4050722
    ENSG00000223367P622692MINT-7945693
    ENSG00000224501P081072MINT-4050722
    ENSG00000226225P622692MINT-7945693
    ENSG00000226788Q065872MINT-7945693
    ENSG00000227322P287022MINT-7947479
    ENSG00000228333P287022MINT-7947479
    ENSG00000228520Q065872MINT-7945693
    ENSG00000231115Q065872MINT-7945693
    ENSG00000231321P287022MINT-7947479
    ENSG00000231555P081072MINT-4050722
    ENSG00000232804P081072MINT-4050722
    ENSG00000234475P081072MINT-4050722
    ENSG00000234507P254402MINT-7947479
    ENSG00000234704P254402MINT-7947479
    ENSG00000235107Q065872MINT-7945693
    ENSG00000235307P254402MINT-7947479
    ENSG00000235650P622692MINT-7945693
    ENSG00000235712P287022MINT-7947479
    ENSG00000235941P081072MINT-4050722
    ENSG00000237724P081072MINT-4050722
    EPB41L3Q9Y2J22MINT-7947479
    ERAL1O756162MINT-7947479
    ERCC1P079922MINT-7947479
    ERCC6LQ2NKX82MINT-7947479
    EWSR1Q018442MINT-7947479
    EXOC1Q9NV702MINT-7945693
    EXOC3O606452MINT-7945693
    EXOSC6Q5RKV62MINT-7945693
    FAF1Q9UNN52MINT-7947479
    FANCD2Q9BXW92MINT-7947479
    FIP1L1Q6UN152MINT-7945693
    FUBP1Q96AE42MINT-7945693
    FYTTD1Q96QD92MINT-7945693
    G3BP2Q9UN862MINT-7945693
    GATAD2BQ8WXI92MINT-7945693
    GEMIN6Q8WXD52MINT-7947479
    GMPSP499152MINT-7947479
    GNA14O958372MINT-7945693
    GNASP630922MINT-7947479
    GNB3P165202MINT-7947479
    GOLGB1Q147892MINT-7947479
    GPS2Q132272MINT-7947479
    GSPT1P151702MINT-7945693
    GTF3C1Q127892MINT-7945693
    GTF3C3Q9Y5Q92MINT-7945693
    GTF3C4Q9UKN82MINT-7945693
    GTF3C5Q9Y5Q82MINT-7947479
    GTPBP1O001782MINT-7947479
    HAUS7Q998712MINT-7947479
    HIC2Q96JB32MINT-7947479
    HNRNPA0Q131512MINT-7945693
    HNRNPA1P096512MINT-7945693
    HNRNPA3P519912MINT-7945693
    HNRNPABQ997292MINT-7945693
    HNRNPDQ141032MINT-7945693
    HNRNPRO433902MINT-7945693
    HSPA1AP081072MINT-4050722
    HSPA1BP081072MINT-4050722
    HSPA2P546522MINT-4050722
    HSPA6P170662MINT-7947479
    HTATSF1O437192MINT-7945693
    HUWE1Q7Z6Z72MINT-7947479
    IKQ131232MINT-7945693
    IKBKAPO951632MINT-7947479
    ILF3Q129062MINT-7945693
    ILKQ134182MINT-7945693
    INTS12Q96CB82MINT-7945693
    INTS6Q9UL032MINT-7947479
    INTS8Q75QN22MINT-7947479
    ITPK1Q135722MINT-7947479
    KANSL1Q7Z3B32MINT-7947479
    KIAA1279Q96EK52MINT-7945693
    KIF27Q86VH22MINT-7945693
    KMT2DO146862MINT-7945693
    KPNA1P522942MINT-7945693
    KTI12Q96EK92MINT-7945693
    LAS1LQ9Y4W22MINT-7947479
    LDLRAP1Q5SW962MINT-7945693
    LENG9Q96B702MINT-7947479
    LMO7Q8WWI12MINT-7947479
    LRRC1Q9BTT62MINT-7947479
    LRRC47Q8N1G42MINT-7945693
    LUC7L2Q9Y3832MINT-7945693
    MAGED2Q9UNF12MINT-7945693
    MAGEE2Q8TD902MINT-7947479
    MAP2K2P365072MINT-7945693
    MAP2K3P467342MINT-7945693
    MAP2K4P459852MINT-7947479
    MAP7Q142442MINT-7947479
    MARK2Q7KZI72MINT-7947479
    MBD3O959832MINT-7945693
    MED12Q930742MINT-7947479
    MED12LQ86YW92MINT-7947479
    MED16Q9Y2X02MINT-7947479
    MELKQ146802MINT-7947479
    METTL13Q8N6R02MINT-7945693
    MLH1P406922MINT-7945693
    MLKLQ8NB162MINT-7945693
    MORF4L1Q9UBU82MINT-7945693
    MORF4L2Q150142MINT-7945693
    MPP2Q141682MINT-7947479
    MTA3Q9BTC82MINT-7947479
    MTCL1Q9Y4B52MINT-7947479
    MYBBP1AQ9BQG02MINT-7947479
    NAT10Q9H0A02MINT-7947479
    NCAPGQ9BPX32MINT-7945693
    NCLP193382MINT-7945693
    NCOR2Q9Y6182MINT-7945693
    NELFCDQ8IXH72MINT-7945693
    NF1P213592MINT-7947479
    NFICP086512MINT-7945693
    NOLC1Q149782MINT-7945693
    NPM1P067482MINT-7947479
    NR2C2P491162MINT-7945693
    NR2F2P244682MINT-7945693
    NR2F6P105882MINT-7945693
    NRG1Q022972MINT-7947479
    NUDT21O438092MINT-7947479
    NUP107P577402MINT-7947479
    NUP153P497902MINT-7945693
    NUP37Q8NFH42MINT-7945693
    NUP93Q8N1F72MINT-7947479
    OLA1Q9NTK52MINT-7945693
    OTULINQ96BN82MINT-7945693
    PABPC1P119402MINT-7945693
    PABPN1Q86U422MINT-7945693
    PAK1Q131532MINT-7945693
    PARP1P098742MINT-7947479
    PARP4Q9UKK32MINT-7945693
    PAXIP1Q6ZW492MINT-7945693
    PBRM1Q86U862MINT-7945693
    PCBP1Q153652MINT-7947479
    PCF11O949132MINT-7945693
    PCNTO956132MINT-7947479
    PDCD6IPQ8WUM42MINT-7945693
    PELOQ9BRX22MINT-7947479
    PELP1Q8IZL82MINT-7945693
    PIK3R4Q995702MINT-7945693
    PKP3Q9Y4462MINT-7945693
    POGZQ7Z3K32MINT-7945693
    POLEQ078642MINT-7945693
    POLR2AP249282MINT-7945693
    POLR2EP193882MINT-7945693
    POLR3DP054232MINT-7947479
    POLR3EQ9NVU02MINT-7947479
    PPFIA1Q131362MINT-7947479
    PPM1DO152972MINT-7947479
    PPP2R1BP301542MINT-7945693
    PRCCQ927332MINT-7947479
    PRPF3O433952MINT-7947479
    PRPF40AO754002MINT-7945693
    PRPF4BQ135232MINT-7947479
    PSMA1P257862MINT-4050722
    PSMA2P257872MINT-4050722
    PSMA3P257882MINT-4050722
    PSMA4P257892MINT-4050722
    PSMA5P280662MINT-4050722
    PSMA6P609002MINT-4050722
    PSMA7O148182MINT-4050722
    PSMB1P206182MINT-4050722
    PSMB2P497212MINT-4050722
    PSMB3P497202MINT-4050722
    PSMB4P280702MINT-4050722
    PSMB5P280742MINT-4050722
    PSMB6P280722MINT-4050722
    PSMB7Q994362MINT-4050722
    PSMD6Q150082MINT-4050722
    PSMD7P516652MINT-4050722
    PSMD8P485562MINT-4050722
    PSME4Q149972MINT-4050722
    PSTPIP2Q9H9392MINT-7947479
    PTBP2Q9UKA92MINT-7947479
    PTBP3O957582MINT-7947479
    PUF60Q9UHX12MINT-7945693
    PURAQ005772MINT-7945693
    RAD21O602162MINT-7945693
    RAE1P784062MINT-7945693
    RAVER1Q8IY672MINT-7947479
    RBBP4Q090282MINT-7947479
    RBM10P981752MINT-7945693
    RBM14Q96PK62MINT-7945693
    RBM15Q96T372MINT-7945693
    RBM7Q9Y5802MINT-7947479
    RFX1P226702MINT-7947479
    RFX5P483822MINT-7947479
    RING1Q065872MINT-7945693
    RIOK1Q9BRS22MINT-7945693
    RNF130Q86XS82MINT-7947479
    RNF17Q9BXT82MINT-7947479
    RNF2Q994962MINT-7945693
    RPL19P840982MINT-7945693
    RPL23AP627502MINT-7945693
    RPL24P837312MINT-7947479
    RPL3P390232MINT-7945693
    RPL36Q9Y3U82MINT-7945693
    RPL4P365782MINT-7945693
    RPL7AP624242MINT-7945693
    RPL8P629172MINT-7945693
    RPS13P622772MINT-7947479
    RPS14P622632MINT-7945693
    RPS18P622692MINT-7945693
    RPS19P390192MINT-7945693
    RPS25P628512MINT-7945693
    RPS3P233962MINT-7945693
    RXRBP287022MINT-7947479
    SCAF8Q9UPN62MINT-7947479
    SCRIBQ141602MINT-7947479
    SEC23AQ154362MINT-7947479
    SEC23BQ154372MINT-7945693
    SEC24CP539922MINT-7947479
    SEC31BQ9NQW12MINT-7945693
    SENP3Q9H4L42MINT-7947479
    SEPT7Q161812MINT-7945693
    SF3A2Q154282MINT-7947479
    SF3B4Q154272MINT-7945693
    SHOC2Q9UQ132MINT-7945693
    SIN3AQ96ST32MINT-7947479
    SKIV2L2P422852MINT-7947479
    SMARCA2P515312MINT-7945693
    SNAPC4Q5SXM22MINT-7947479
    SND1Q7KZF42MINT-7945693
    SNRPAP090122MINT-7947479
    SNRPA1P096612MINT-7947479
    SNRPB2P085792MINT-7945693
    SNRPD1P623142MINT-7947479
    SNRPEP623042MINT-7947479
    SNUPNO951492MINT-7945693
    SNX12Q9UMY42MINT-7947479
    SNX2O607492MINT-7947479
    SPATA5L1Q9BVQ72MINT-7945693
    SPENQ96T582MINT-7947479
    SREK1Q8WXA92MINT-7947479
    SRP19P091322MINT-7945693
    SRSF11Q055192MINT-7945693
    SRSF2Q011302MINT-7945693
    SRSF3P841032MINT-7945693
    SRSF4Q081702MINT-7947479
    SRSF5Q132432MINT-7945693
    SRSF6Q132472MINT-7945693
    SSUH2Q9Y2M22MINT-7947479
    STAB1Q9NY152MINT-7947479
    STAG1Q8WVM72MINT-7945693
    STAG2Q8N3U42MINT-7947479
    STAT3P407632MINT-7947479
    STK24Q9Y6E02MINT-7947479
    SUMO1P631652MINT-7947479
    SUPT16HQ9Y5B92MINT-7947479
    SUPV3L1Q8IYB82MINT-7945693
    SYNCRIPO605062MINT-7945693
    TAF12Q165142MINT-7945693
    TAF15Q928042MINT-7947479
    TAF5LO755292MINT-7947479
    TAF9Q165942MINT-7945693
    TANC2Q9HCD62MINT-7947479
    TAOK1Q7L7X32MINT-7945693
    THAP1Q9NVV92MINT-7947479
    THOC1Q96FV92MINT-7945693
    THOC2Q8NI272MINT-7945693
    TLN2Q9Y4G62MINT-7947479
    TMOD3Q9NYL92MINT-7947479
    TNFAIP2Q031692MINT-7947479
    TNKS1BP1Q9C0C22MINT-7947479
    TOX4O948422MINT-7945693
    TPRP122702MINT-7947479
    TPX2Q9ULW02MINT-7947479
    TRIM21P194742MINT-7947479
    TRMT1LQ7Z2T52MINT-7947479
    TRRAPQ9Y4A52MINT-7947479
    TTKP339812MINT-7945693
    TUBA1CQ9BQE32MINT-7947479
    TUBA3EQ6PEY22MINT-7945693
    TUBGCP4Q9UGJ12MINT-7947479
    TUFMP494112MINT-7945693
    UBE2Q1Q7Z7E82MINT-7945693
    UBE2SQ167632MINT-7947479
    UBN1Q9NPG32MINT-7947479
    UMPSP111722MINT-7947479
    USO1O607632MINT-7947479
    USP10Q146942MINT-7947479
    USP24Q9UPU52MINT-7947479
    USP48Q86UV52MINT-7945693
    VASPP505522MINT-7945693
    VPS33AQ96AX12MINT-7947479
    VPS36Q86VN12MINT-7947479
    VPS51Q9UID32MINT-7947479
    VRK1Q999862MINT-7945693
    WAPALQ7Z5K22MINT-7945693
    WDR5P619642MINT-7945693
    WIZO957852MINT-7945693
    WRNIP1Q96S552MINT-7947479
    XPO6Q96QU82MINT-7945693
    XRCC6P129562MINT-7945693
    YBX3P169892MINT-7945693
    YEATS4O956192MINT-7947479
    YLPM1P497502MINT-7947479
    YTHDC2Q9H6S02MINT-7945693
    YWHAEP622582MINT-7947479
    YY1P254902MINT-7945693
    ZBTB7CA1YPR02MINT-7947479
    ZC3HC1Q86WB02MINT-7947479
    ZNF326Q5BKZ12MINT-7945693
    DYNC1I1ENSP000003201304STRING: ENSP00000320130
    DYNC1I2ENSP000003803084STRING: ENSP00000380308
    GJA1ENSP000002825614STRING: ENSP00000282561
    TUBB4AENSP000002640714STRING: ENSP00000264071
    TUBB6ENSP000003186974STRING: ENSP00000318697
    GUCA1AENSP000000534694STRING: ENSP00000053469
    RCVRNENSP000002261934STRING: ENSP00000226193
    SAGENSP000003864444STRING: ENSP00000386444
    TPPPENSP000003537854STRING: ENSP00000353785
    TUBB2AENSP000003697034STRING: ENSP00000369703
    TUBB2BENSP000002598184STRING: ENSP00000259818
    PEX14ENSP000003490164STRING: ENSP00000349016
    FBXO25ENSP000002763264STRING: ENSP00000276326
    IQCB1ENSP000003115054STRING: ENSP00000311505
    KNCNENSP000003796074STRING: ENSP00000379607
    MAD2L1ENSP000002965094STRING: ENSP00000296509
    TBCDENSP000003477194STRING: ENSP00000347719
    FOXE1ENSP000003642654STRING: ENSP00000364265
    MAPRE3ENSP000002331214STRING: ENSP00000233121
    TBCAENSP000003697364STRING: ENSP00000369736
    CLASP2ENSP000003525814STRING: ENSP00000352581
    H2AFVENSP000003084054STRING: ENSP00000308405
    H2AFZENSP000002964174STRING: ENSP00000296417
    MAPRE2ENSP000003002494STRING: ENSP00000300249
    ACTR6ENSP000001883124STRING: ENSP00000188312
    CTDP1ENSP000002995434STRING: ENSP00000299543
    PAN3ENSP000002823914STRING: ENSP00000282391
    WDR25ENSP000003341484STRING: ENSP00000334148
    KIF18AENSP000002631814STRING: ENSP00000263181
    KIF18BENSP000003414664STRING: ENSP00000341466
    KIF19ENSP000003745664STRING: ENSP00000374566
    ENSG00000204197ENSP000003636474STRING: ENSP00000363647
    ENSG00000233450ENSP000004078854STRING: ENSP00000407885
    KIFC1ENSP000003939634STRING: ENSP00000393963
    MAP4ENSP000003533754STRING: ENSP00000353375
    KIF25ENSP000003464014STRING: ENSP00000346401
    KIFC2ENSP000003013324STRING: ENSP00000301332
    ARL2ENSP000002467474STRING: ENSP00000246747
    RHOAENSP000004001754STRING: ENSP00000400175
    ARL13AENSP000004147574STRING: ENSP00000414757
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000226microtubule cytoskeleton organization ----
    GO:0000278mitotic cell cycle TAS--
    GO:0002576platelet degranulation TAS--
    GO:0006184GTP catabolic process ----

    Find genes that share ontologies with TUBA4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
    9 ApexBio Compounds for TUBA4A     About this table
    CompoundAction CAS #
    7-xylosyltaxoltaxol (Paclitaxel) derivative[90332-66-4]
    ColchicineColchicine, a tubulin Inhibitor[64-86-8]
    D-64131novel inhibitor of Tubulin polymerization[74588-78-6]
    Docetaxel Trihydrateinhibitor of depolymerisation of microtubules[148408-66-6]
    Mc-MMADPotent tubulin inhibitor[1401963-15-2]
    MMADPotent tubulin inhibitor[203849-91-6]
    Monomethyl auristatin EAntimitotic agent[474645-27-7]
    PodophyllotoxinActions Inhibits microtubule assembly[518-28-5]
    Vc-MMADantibody drug conjugate[1401963-17-4]

    Compounds for TUBA4A available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 HMDB Compound for TUBA4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 DrugBank Compounds for TUBA4A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Podofilox-- 477-47-4targetinhibitor1411635 20979080 20814887 20810285 19286405 20657644
    Vincristine22-Oxovincaleukoblastine (see all 12)57-22-7targetinhibitor11168494 20691709 20442307
    Epothilone BEPO 906 (see all 3)152044-54-7target--17139284 17016423
    Epothilone D-- 189453-10-9target--17139284 17016423
    CabazitaxelRPR-116258A (see all 5)183133-96-2targetbinder--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUBA4A gene (2 alternative transcripts): 
    NM_001278552.1  NM_006000.2  

    Unigene Cluster for TUBA4A:

    Tubulin, alpha 4a
    Hs.75318  [show with all ESTs]
    Unigene Representative Sequence: AK054731
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000248437(uc002vkt.1) ENST00000392088(uc010zkz.1) ENST00000498660
    ENST00000398989 ENST00000427737 ENST00000456818 ENST00000447205 ENST00000462806
    ENST00000475683 ENST00000425551
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TUBA4A using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TUBA4A:
    hsa-miR-450b-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TUBA4A
    Predesigned siRNA for gene silencing in human, mouse, rat TUBA4A
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    OriGene clones in human, mouse for TUBA4A (see all 7)
    OriGene ORF clones in mouse, rat for TUBA4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBA4A (NM_006000)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA4A
    Primer
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    OriGene qPCR primer pairs and template standards for TUBA4A
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBA4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBA4A
      QuantiTect SYBR Green Assays in human, mouse, rat TUBA4A
      QuantiFast Probe-based Assays in human, mouse, rat TUBA4A

    Additional mRNA sequence: 

    AK054731.1 AK299958.1 BC009238.2 BC018854.2 BT006731.1 

    21 DOTS entries:

    DT.100810985  DT.95119848  DT.118885  DT.100810991  DT.121017611  DT.100810992  DT.95258481  DT.121017614 
    DT.100810987  DT.121017490  DT.121017682  DT.91768481  DT.100810984  DT.100810990  DT.121017583  DT.121017618 
    DT.86845545  DT.121017629  DT.91724808  DT.120658537  DT.120697624 

    Selected AceView cDNA sequences (see all 486):

    H45088 BM561700 BQ688607 BG697371 BQ054375 BM543121 BI836113 F03923 
    F25814 BQ061051 F04584 CB106763 CR620681 BG677642 F08327 BP366721 
    BM724739 BC009238 BQ054189 BE018124 AA858420 BQ061291 AI811117 BE795269 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TUBA4A    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b
    SP1:        -                                       
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for TUBA4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBA4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGAGGGTG
    TUBA4A Expression
    About this image


    TUBA4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Primary Oocyte Primary Follicle
             Oviduct
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
    TUBA4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBA4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75318
        Pathway & Disease-focused RT2 Profiler PCR Array including TUBA4A: 
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUBA4A
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBA4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBA4A
    QuantiTect SYBR Green Assays in human, mouse, rat TUBA4A
    QuantiFast Probe-based Assays in human, mouse, rat TUBA4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBA4A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tuba4a1 , 5 tubulin, alpha 4A1, 5 92.56(n)1
    100(a)1
      1 (38.63 cM)5
    221451  NM_009447.31  NP_033473.11 
     752149745 
    chicken
    (Gallus gallus)
    Aves LOC1008572141 tubulin alpha-4A chain-like 86.53(n)
    96.43(a)
      100857214  XM_003641643.2  XP_003641691.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    97(a)
    97(a)
    1 ↔ many
    1 ↔ many
    1(95682244-95703717)
    1(95691343-95730606)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tuba4b1 tubulin, alpha 4b 84.9(n)
    98.21(a)
      549448  NM_001016694.2  NP_001016694.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tuba8l31 tubulin, alpha 8 like 3 81.55(n)
    94.87(a)
      445164  NM_001003558.1  NP_001003558.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaTub85E6
    alpha-Tubulin at 85E
    94(a)
    1 ↔ 1
    3R(5556943-5558987)
    worm
    (Caenorhabditis elegans)
    Secernentea mec-126
    Protein MEC-12 (mec-12) mRNA, complete cds
    91(a)
    1 ↔ 1
    III(3131574-3139221) WBGene00003175
    soybean
    (Glycine max)
    eudicotyledons Gma.166742 Transcribed sequence with strong similarity to protein more 78.6(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.217622 O.sativa mRNA for alpha-tubulin (clone OSTA-136) 79.58(n)    AK102560.1 


    ENSEMBL Gene Tree for TUBA4A (if available)
    TreeFam Gene Tree for TUBA4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBA4A gene
    TUBA3C2  TUBA1B2  TUBA1A2  TUBA3E2  TUBA1C2  TUBA82  TUBA3D2  
    Selected SIMAP similar genes for TUBA4A using alignment to 7 protein entries:     TBA4A_HUMAN (see all proteins) (see all similar genes):
    TUBA2    TUBA3C    TUBA3D    TUBA3E    TUBA1A    TUBA1
    TUBA1C    TUBA1B    TUBA4B    TUBA8    DKFZp686L04275    TUBAL3
    MGC16703    TUBB2A    TUBB2B    TUBB4A    TUBB6    TUBB3

    Find genes that share paralogs with TUBA4A           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for TUBA4A (see all 9)
    PGOHUM00000242759 PGOHUM00000239767 PGOHUM00000239052 PGOHUM00000240390 PGOHUM00000250484


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBA4A (see all 110)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900095031,2
    --219496141(+) TCAAAA/GCGCAG 2 R syn10--------
    rs1998811971,2
    C--219496143(+) AAAGCA/GCAGAG 2 R C mis10--------
    rs1928346601,2
    C--219496509(+) AAGAAC/G/TGAGAA 1 -- int10--------
    rs1164863241,2
    C,F--219496510(+) AGAACG/AAGAAA 1 -- int11Minor allele frequency- A:0.02WA 118
    rs2006327861,2
    --219496539(+) AGGGGA/CCTGAG 1 -- int10--------
    rs1848375401,2
    --219496574(+) AGCGTA/GAGATA 1 -- int10--------
    rs2016492831,2
    --219496779(+) CCTTGC/TCAATG 2 D G mis10--------
    rs2011720871,2
    --219496782(+) TGCCAA/GTGGTA 2 T I mis10--------
    rs2006510961,2
    --219496783(+) GCCAAC/TGGTAT 2 I V mis10--------
    rs1995790961,2
    C--219496787(+) ATGGTA/GTAGTG 2 Y syn10--------

    HapMap Linkage Disequilibrium report for TUBA4A (220114433 - 220142892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TUBA4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508885CNV Insertion20534489
    nsv834543CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBA4A
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBA4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191110    OMIM disorders: --


    Find genes that share disorders with TUBA4A           About GenesLikeMe

    Genetic Association Database (GAD): TUBA4A
    Human Genome Epidemiology (HuGE) Navigator: TUBA4A (1 document)

    Export disorders for TUBA4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBA4A gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with TUBA4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region. (PubMed id 3029670)1, 2 Dobner P.R.... Villa-Komaroff L. (Nucleic Acids Res. 1987)
    5. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis- specific expression of two sister genes. (PubMed id 3785200)1, 3 Villasante A.... Cowan N.J. (Mol. Cell. Biol. 1986)
    6. Acetylated I+-tubulin is reduced in individuals with poor sperm motility. (PubMed id 24268707)1 Bhagwat S....Parte P. (Fertil. Steril. 2014)
    7. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    8. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7277 HGNC: 12407 AceView: TUBA1 Ensembl:ENSG00000127824 euGenes: HUgn7277
    ECgene: TUBA4A Kegg: 7277 H-InvDB: TUBA4A