TUBA4A Gene

Aliases
for TUBA4A gene

Previous GC identifers: GC02M219823 GC02M211967

Summaries
for TUBA4A gene

Genomic Views
for TUBA4A gene

RefSeq DNA sequence:

NC_000002.11  NC_018913.1  NT_005403.17  

SwitchGear Promoter luciferase reporter plasmid: TUBA4A promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA4A

TUBA4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M220114:  view genomic region     (about GC identifiers)

Proteins
for TUBA4A gene

Explore the universe of human proteins at neXtProt for TUBA4A: NX_P68366

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TUBA4A OriGene Custom Protein Services for TUBA4A
	GenScript Custom Purified and Recombinant Proteins Services for TUBA4A
	Novus Biologicals TUBA4A Protein Novus Biologicals TUBA4A Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	OriGene Antibodies: TUBA4A OriGene Custom Antibody Services for TUBA4A
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	Novus Biologicals TUBA4A Antibodies
	Search for Antibodies for TUBA4A at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibody for TUBA4A

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TUBA4A
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

Protein Domains /
Families
for TUBA4A gene

ProtoNet protein and cluster: P68366

Function
for TUBA4A gene

miRNA Products:		OriGene 3'-UTR Clone: TUBA4A Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBA4A
		1 QIAGEN miScript miRNA Assays for microRNA that regulate TUBA4A:
		hsa-miR-450b-5p
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBA4A (see all 7) OriGene shRNA RFP: TUBA4A OriGene siRNA: TUBA4A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA4A

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TUBA4A

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA4A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA4A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TUBA4A (NM_006000)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA4A
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA4A

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TUBA4A
		Search LifeMap BioReagents cell lines for TUBA4A

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA4A

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for TUBA4A gene

	Super-pathway	contained gene-specific pathways
1	Recruitment of mitotic centrosome proteins and complexes	Recruitment of mitotic centrosome proteins and complexes 1.00 Mitotic G2-G2/M phases 0.81 Centrosome maturation 1.00 Loss of proteins required for interphase microtubule organization from the centrosome 0.78 G2/M Transition 0.83 Loss of Nlp from mitotic centrosomes 0.78
2	M Phase	M Phase 1.00 Mitotic Anaphase 0.85 Mitotic M-M/G1 phases 0.88 Separation of Sister Chromatids 0.80 Mitotic Metaphase and Anaphase 0.85
3	Axon guidance	Axon guidance 1.00 L1CAM interactions 0.39 Developmental Biology 0.69 Recycling pathway of L1 0.15
4	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 1.00 Post-chaperonin tubulin folding pathway 0.67 Transport of connexons to the plasma membrane 0.93 Recruitment of NuMA to mitotic centrosomes 0.50
5	Formation of tubulin folding intermediates by CCT/TriC	Formation of tubulin folding intermediates by CCT/TriC 1.00 Prefoldin mediated transfer of substrate to CCT/TriC 0.70 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding 0.74

5/9 EMD Millipore Pathways for TUBA4A

	Cytoskeleton remodeling Neurofilaments
	Cytoskeleton remodeling Slit-Robo signaling
	Cytoplasmic microtubules
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cytoskeleton remodeling Keratin filaments

5/10 GeneGo (Thomson Reuters) Pathways for TUBA4A

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Cell cycle Spindle assembly and chromosome separation
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Keratin filaments

2 BioSystems Pathways for TUBA4A

	Parkin-Ubiquitin Proteasomal System pathway
	Pathogenic Escherichia coli infection

5/46        Reactome Pathways for TUBA4A

	L1CAM interactions
	Mitotic Prometaphase
	Membrane Trafficking
	Protein folding
	Recruitment of mitotic centrosome proteins and complexes

3         Kegg Pathways  (Kegg details for TUBA4A)

	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

Drugs & Compounds
for TUBA4A gene

Transcripts
for TUBA4A gene

Expression
for TUBA4A gene

TUBA4A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGGAGGGTG

4 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic Angioblasts			Endothelium
	OvaryPrimary FolliclePrimary Oocyte			Female Gametocytes, Germ Cells
	Skeletal MuscleHyoid Arch MusclesMuscle Progenitor Cells			Skeletal Muscle
	Skeletal MuscleMandibular Arch MusclesMuscle Progenitor Cells			Skeletal Muscle
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 4 LifeMap Cells
	Name			Category
	PureStem™ progenitor T36 (Embryonic Progenitor Cell)
	ES04(HES-4) (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Line H9 (WA09) (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Cardiomyocyte-like cells (Spontaneous differen...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA4A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TUBA4A
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA4A
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA4A

In Situ Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA4A

Orthologs
for TUBA4A gene

Paralogs
for TUBA4A gene

Paralogs for TUBA4A gene

TUBA3C²  TUBA1C²  TUBA3D²  TUBA1B²  TUBAL3²  TUBA1A²  TUBA3E²  TUBA8²  

18/29 SIMAP similar genes for TUBA4A using alignment to 7 protein entries:     TBA4A_HUMAN (see all proteins) (see all similar genes):

TUBA2    TUBA3C    TUBA3D    TUBA3E    TUBA1    TUBA1A

TUBA1C    TUBA1B    TUBA4B    TUBA8    DKFZp686L04275    TUBAL3

MGC16703    TUBB2A    TUBB2B    TUBB6    TUBB3    TUBB4Q

TUBA4A for paralogs           About GeneDecksing


5/9 Pseudogenes.org Pseudogenes for TUBA4A (see all 9)
PGOHUM00000242759 PGOHUM00000239767 PGOHUM00000239052 PGOHUM00000240390 PGOHUM00000250484

Genomic Variants
for TUBA4A gene

10/98 NCBI SNPs in TUBA4A are shown (see all 98)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs115563481,2	C	--	211969736(-)	GGAGGG/TGACGA	1	--	us2k1 ese3		1		NA	2
rs605000761,2	C,	--	211969987(+)	GGAGGG/CTTGGG	1	--	us2k1		2		WA	120
rs455760411,2	C,F,	--	211970179(-)	GGGGGC/G/TGCCTC	1	--	us2k1		6		NS WA	170
rs456170401,2	C,F	--	211970184(-)	GTGGGG/TGGGGG	1	--	us2k1		6		NS WA	182
rs596233141,2	C,	--	211970227(+)	TAGAAT/CTCATA	1	--	us2k1		2		WA	120
rs787698421,2	C,F,	--	211970253(+)	TTCTTT/CCCTGT	1	--	us2k1		1		WA	118
rs729554591,2	C,F,	--	211970343(+)	AAATCC/TCATCT	1	--	us2k1		1		NA	120
rs1998086111,2	C	--	211971002(-)	GAACCA/CCCCCC	1	--	nc-transcript-variant		0	--	--	--	--
rs454680951,2	C,	--	211971395(-)	GGGCGT/CTCCGG	1	--	int1		5		NS	160
rs129886891,2	H	--	211971631(+)	AGAGGC/ATGGGC	1	--	int1		4		NS EA	418

HapMap Linkage Disequilibrium report for TUBA4A (220114433 - 220142892 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for TUBA4A: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBA4A

DNA2.0 Custom Variant and Variant Library Synthesis for TUBA4A

Disorders / Diseases
for TUBA4A gene

Publications
for TUBA4A gene

PubMed articles for TUBA4A gene, integrated from 9 sources (see all 143) (see top 10): (articles sorted by number of sources associating them with TUBA4A)

Utopia: connect your pdf to the dynamic world of online information

1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
3. Alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region. (PubMed id 3029670)^{1, 2} Dobner P.R.... Villa-Komaroff L. (1987)
4. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis- specific expression of two sister genes. (PubMed id 3785200)^{1, 3} Villasante A.... Cowan N.J. (1986)
5. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
6. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)¹ Naji S....Gerace L. (2012)
7. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
8. The interaction between ubiquitin C-terminal hydrolas e 37 and glucose-regulated protein 78 in hepatocellular carcinoma. (PubMed id 21800051)¹ Fang Y....Shen X. (2012)
9. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
10. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)¹ Martins-de-Souza D....Bahn S. (2012)
11. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
12. Postmortem proteomic analysis in human amygdala of dr ug addicts: possible impact of tubulin on drug-abusing behavior. (PubMed id 20686780)¹ Zill P....Bondy B. (2011)
13. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)¹ Shi Y....Qin J. (2011)
14. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)¹ Emanuele M.J....Elledge S.J. (2011)
15. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)¹ Lee K.A....Doedens J.R. (2011)
16. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
17. Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715)¹ Lai Y....Shiio Y. (2011)
18. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
19. Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity. (PubMed id 21167302)¹ Yamamoto S.P....Suzuki Y. (2011)
20. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
21. Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970)¹ Teixeira F.R.... Gomes M.D. (2010)
22. Design, synthesis, and biological evaluation of the f irst podophyllotoxin analogues as potential vascular-disrupting agents. (PubMed id 20979080)⁷ LabruA"re R....Giorgi-Renault S. (2010)
23. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
24. Dynamic subunit exchange and the regulation of microt ubule assembly by the stress response protein human alphaB crystallin. (PubMed id 20668689)¹ Houck S.A. and Clark J.I. (2010)
25. The role of height-associated loci identified in geno me wide association studies in the determination of pediatric stature. (PubMed id 20546612)¹ Zhao J....Grant S.F. (2010)
26. Live cell imaging of micronucleus formation and devel opment. (PubMed id 20691709)⁷ Yasui M....Honma M. (2010)
27. Competitive mass spectrometry binding assay for chara cterization of three binding sites of tubulin. (PubMed id 20814887)⁷ Li C.M....Dalton J.T. (2010)
28. A screen for kinetochore-microtubule interaction inhi bitors identifies novel antitubulin compounds. (PubMed id 20657644)⁷ Screpanti E....De Wulf P. (2010)
29. Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin. (PubMed id 20442307)⁷ Gan P.P....Kavallaris M. (2010)
30. Structure-based virtual screening of novel tubulin in hibitors and their characterization as anti-mitotic agents. (PubMed id 20810285)⁷ Kim N.D....Kim K.H. (2010)
31. An integrated workflow for charting the human interac tion proteome: insights into the PP2A system. (PubMed id 19156129)¹ Glatter T....Gstaiger M. (2009)
32. Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PubMed id 19524510)² Rogowski K....Janke C. (2009)
33. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)¹ Vanderwerf S.M....Bagby G.C. (2009)
34. Applying linear interaction energy method for binding affinity calculations of podophyllotoxin analogues with tubulin using continuu m solvent model and prediction of cytotoxic activity. (PubMed id 19286405)⁷ Alam M.A. and Naik P.K. (2009)
35. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
36. Susceptibility to virus-cell fusion at the plasma membrane is reduced through expression of HIV gp41 cytoplasmic domains. (PubMed id 18400243)¹ Malinowsky K....Dittmar M.T. (2008)
37. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)¹ Gudbjartsson D.F....Stefansson K. (2008)
38. Phosphoproteome of resting human platelets. (PubMed id 18088087)² Zahedi R.P.... Sickmann A. (2008)
39. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)² Daub H.... Mann M. (2008)
40. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)
41. Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat. (PubMed id 18613978)¹ Egele C....Mely Y. (2008)
42. Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach. (PubMed id 17314511)¹ Koch H.B....Hermeking H. (2007)
43. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599)¹ Xiao K....Lefkowitz R.J. (2007)
44. Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. (PubMed id 17360745)¹ Jolly C....Sattentau Q.J. (2007)
45. Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. (PubMed id 16327313)¹ Canani R.B....Guarino A. (2006)
46. The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation. (PubMed id 16462731)¹ Petretti C....Giet R. (2006)
47. Tubulin nitration in human gliomas. (PubMed id 16257120)¹ Fiore G....d'Ischia M. (2006)
48. How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
49. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
50. Dynamic profiling of the post-translational modificat ions and interaction partners of epidermal growth factor receptor signaling aft er stimulation by epidermal growth factor using Extended Range Proteomic Analys is (ERPA). (PubMed id 16799092)¹ Wu S.L....Karger B.L. (2006)
51. HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? (PubMed id 15698476)¹ Giacca M. (2005)
52. MYND domain specific interaction of the melanin-concentrating hormone receptor 1 interacting zinc-finger protein with alpha- and beta-tubulin. (PubMed id 16039987)¹ Francke F....Bachner D. (2005)
53. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)¹ Rush J.... Comb M.J. (2005)
54. HIV-1 Tat protein enhances microtubule polymerization. (PubMed id 15691386)¹ de Mareuil J....Loret E.P. (2005)
55. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
56. Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. (PubMed id 15659558)¹ Zheng H....Wang Y.K. (2005)
57. Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin. (PubMed id 16159877)¹ McCracken S....Blencowe B.J. (2005)
58. Histone deacetylase 6 regulates human immunodeficiency virus type 1 infection. (PubMed id 16148047)¹ Valenzuela-Fernandez A....Sanchez-Madrid F. (2005)
59. Protein tyrosine nitration in rat brain is associated with raft proteins, flotillin-1 and alpha-tubulin: effect of biological aging. (PubMed id 15934946)¹ Dremina E.S....Schoneich C. (2005)
60. Protein 4.1R, a microtubule-associated protein involved in microtubule aster assembly in mammalian mitotic extract. (PubMed id 15184364)¹ Huang S.C....Benz E.J. (2004)
61. Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. (PubMed id 14630798)¹ Coppinger J.A....Maguire P.B. (2004)
62. Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding. (PubMed id 14634002)¹ Simons C.T....Cowan N.J. (2004)
63. MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes. (PubMed id 14594945)¹ Trinczek B....Drewes G. (2004)
64. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)¹ Jin J....Pawson T. (2004)
65. Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins. (PubMed id 12963086)¹ Bhaskar K....Shetty K.T. (2004)
66. Phosphoproteomic analysis of the developing mouse brain. (PubMed id 15345747)¹ Ballif B.A.... Gygi S.P. (2004)
67. The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis. (PubMed id 15331610)¹ Campbell G.R....Loret E.P. (2004)
68. HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy. (PubMed id 15103018)¹ Xu Y....Pomerantz R.J. (2004)
69. Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro. (PubMed id 15129282)¹ Ozaki K....Tanaka T. (2004)
70. Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. (PubMed id 14697242)¹ Nagaraja G.M. and Kandpal R.P. (2004)
71. Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. (PubMed id 12852856)¹ Casenghi M....Nigg E.A. (2003)
72. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. (PubMed id 12620231)¹ North B.J.... Verdin E. (2003)
73. Parkin binds to alpha/beta tubulin and increases their ubiquitination and degradation. (PubMed id 12716939)¹ Ren Y....Feng J. (2003)
74. The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. (PubMed id 12639963)¹ Mitsopoulos C.... Morris J.D. (2003)
75. Identification of alpha-tubulin as an hsp105alpha-binding protein by the yeast two-hybrid system. (PubMed id 12749852)¹ Saito Y....Hatayama T. (2003)
76. Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. (PubMed id 12482968)¹ Goo Y.-H....Lee J.W. (2003)
77. Rab8B GTPase and junction dynamics in the testis. (PubMed id 12639940)¹ Lau A.S. and Mruk D.D. (2003)
78. Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. (PubMed id 12054644)¹ Banerjee A. (2002)
79. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. (PubMed id 12134159)¹ Fukata Y....Kaibuchi K. (2002)
80. HDAC6 is a microtubule-associated deacetylase. (PubMed id 12024216)¹ Hubbert C.... Yao T.-P. (2002)
81. Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex. (PubMed id 12052837)¹ Vainauskas S....Menon A.K. (2002)
82. Interaction between metabotropic glutamate receptor 7 and alpha tubulin. (PubMed id 11953448)¹ Saugstad J.A....Conn P.J. (2002)
83. Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. (PubMed id 11964161)¹ Ivings L....Burgoyne R.D. (2002)
84. Subcellular localization of the BRCA1 gene product in mitotic cells. (PubMed id 12353262)¹ Lotti L.V....Mariani-Costantini R. (2002)
85. Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex. (PubMed id 12221128)¹ Takahashi M....Ono Y. (2002)
86. Tubulin is an inherent component of mitochondrial membranes that interacts with the voltage-dependent anion channel. (PubMed id 12087096)¹ Carre M....Braguer D. (2002)
87. Nogo-A expression in mature oligodendrocytes of rat spinal cord in association with specific molecules. (PubMed id 12377379)¹ Taketomi M....Ide C. (2002)
88. HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim. (PubMed id 12486001)¹ Chen D....Zhou Q. (2002)
89. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
90. The tubulin fraternity: alpha to eta. (PubMed id 11163133)¹ Dutcher S.K. (2001)
91. Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation. (PubMed id 11278895)¹ Bonnet C....Larcher J.C. (2001)
92. Role of MgcRacGAP/Cyk4 as a regulator of the small GTPase Rho family in cytokinesis and cell differentiation. (PubMed id 11942621)¹ Kitamura T....Nosaka T. (2001)
93. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation. (PubMed id 11166179)¹ Zumbrunn J....Nathke I.S. (2001)
94. Chloride intracellular channel protein CLIC4 (p64H1) binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. (PubMed id 11563969)¹ Suginta W....Ashley R.H. (2001)
95. An abundance of tubulins. (PubMed id 11121746)¹ Oakley B.R. (2000)
96. The centrosomal protein C-Nap1 is required for cell cycle-regulated centrosome cohesion. (PubMed id 11076968)¹ Mayor T....Nigg E.A. (2000)
97. HIV-1 rev depolymerizes microtubules to form stable bilayered rings. (PubMed id 10908577)¹ Watts N.R....Steven A.C. (2000)
98. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. (PubMed id 11146551)¹ Germani A.... Calvo F. (2000)
99. Association between the calcium-binding protein calretinin and cytoskeletal components in the human colon adenocarcinoma cell line WiDr. (PubMed id 10942575)¹ Marilley D. and Schwaller B. (2000)
100. Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro. (PubMed id 11168494)⁷ Vilpo J.A....Vilpo L.M. (2000)
101. Alf1p, a CLIP-170 domain-containing protein, is functionally and physically associated with alpha-tubulin. (PubMed id 9885248)¹ Feierbach B....Stearns T. (1999)
102. Identification of a domain in guanylyl cyclase-activating protein 1 that interacts with a complex of guanylyl cyclase and tubulin in photoreceptors. (PubMed id 10037711)¹ Schrem A....Koch K.W. (1999)
103. Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex. (PubMed id 10191277)¹ Feng Y....Ferris D.K. (1999)
104. Tubulin and FtsZ structures: functional and therapeutic implications. (PubMed id 9722999)¹ Desai A. and Mitchison T.J. (1998)
105. Characterization of the microtubule-binding domain of microtubule-associated protein 1A and its effects on microtubule dynamics. (PubMed id 9593747)¹ Vaillant A.R....Brown D.L. (1998)
106. The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains. (PubMed id 9922135)¹ Chau M.F....Feinstein S.C. (1998)
107. Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors. (PubMed id 9265649)¹ Tian G....Cowan N.J. (1997)
108. Functionally distinct isoforms of dynactin are expressed in human neurons. (PubMed id 8856662)¹ Tokito M.K.... Holzbaur E.L.F. (1996)
109. Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. (PubMed id 8617742)¹ Peters J.D....Geahlen R.L. (1996)
110. The Ras-related GTPase Rac1 binds tubulin. (PubMed id 8631991)¹ Best A....Lim L. (1996)
111. The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. (PubMed id 7651436)¹ Alexandrova N....Zajac-Kaye M. (1995)
112. Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. (PubMed id 7790358)¹ Golsteyn R.M....Nigg E.A. (1995)
113. Golgi retention mechanism of beta-1,4-galactosyltransferase. Membrane-spanning domain-dependent homodimerization and association with alpha- and beta-tubulins. (PubMed id 7744867)¹ Yamaguchi N. and Fukuda M.N. (1995)
114. The p150Glued component of the dynactin complex binds to both microtubules and the actin-related protein centractin (Arp-1). (PubMed id 7878030)¹ Waterman-Storer C.M....Holzbaur E.L. (1995)
115. Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells. (PubMed id 8530437)¹ Huby R.D....Ley S.C. (1995)
116. Human T lymphocyte activation induces tyrosine phosphorylation of alpha-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase. (PubMed id 8566014)¹ Marie-Cardine A....Schraven B. (1995)
117. In vitro analysis of microtubule assembly of isotypically pure tubulin dimers. Intrinsic differences in the assembly properties of alpha beta II, alpha beta III, and alpha beta IV tubulin dimers in the absence of microtubule-associated proteins. (PubMed id 8294455)¹ Lu Q. and Luduena R.F. (1994)
118. Characterization of a 50-kDa polypeptide in cytoplasmic dynein preparations reveals a complex with p150GLUED and a novel actin. (PubMed id 8325901)¹ Paschal B.M....Vallee R.B. (1993)
119. Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives. (PubMed id 1411635)⁷ Clark P.I. (1992)
120. The 93-kDa glycine receptor-associated protein binds to tubulin. (PubMed id 1657993)¹ Kirsch J....Betz H. (1991)
121. Structural features and restricted expression of a human alpha- tubulin gene. (PubMed id 3839072)¹ Hall J.L. and Cowan N.J. (1985)
122. Characterization of the proteins of isolated human platelet alpha-granules. Evidence for a separate alpha-granule-pool of the glycoproteins IIb and IIIa. (PubMed id 6457647)¹ Gogstad G.O....Solum N.O. (1981)
123. Protein levels of alpha1-tubulin, protein disulfide isomerase, tropomyosins and vimentin are regulated by the tuberous sclerosis gene products. (PubMed id 15183538)⁹ Hengstschlager M....Lubec G. (2004)
124. Mutations in alpha-tubulin cause abnormal neuronal migration in mice and lissencephaly in humans. (PubMed id 17218254)⁹ Keays D.A....Flint J. (2007)
125. Immature corticospinal neurons respond to axotomy with changes in tubulin gene expression. (PubMed id 8457896)⁹ Kost S.A. and Oblinger M.M. (1993)
126. Molecular cloning of three rice alpha-tubulin isotypes: differential expression in tissues and during flower development. (PubMed id 9375785)⁹ Qin X....Breviario D. (1997)
127. Decortication and striatal mRNA: increases of mRNA for fibronectin, but not of NCAM or alpha-1 tubulin. (PubMed id 1421087)⁹ Popa-Wagner A....Pasinetti G.M. (1992)
128. Dinucleotide repeat polymorphism in the human tubulin alpha 1 (testis specific) gene (TUBA1). (PubMed id 1852622)⁹ Todd S. and Naylor S.L. (1991)
129. Determination of insoluble avian eggshell matrix prot eins. (PubMed id 19998026)⁹ MiksA-k I....Eckhardt A. (2010)
130. Neuropathological phenotype of a distinct form of lissencephaly associated with mutations in TUBA1A. (PubMed id 18669490)⁹ Fallet-Bianco C....Francis F. (2008)
131. Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones. (PubMed id 16421324)⁹ Gal J.S....Haydar T.F. (2006)
132. Targeting brain stem centers of cardiovascular control using adenoviral vectors: impact of promoters on transgene expression. (PubMed id 15561757)⁹ Lonergan T....Kasparov S. (2005)
133. Identification by means of cDNA microarray analyses of gene expression modifications in squamous non-small cell lung cancers as compared to normal bronchial epithelial tissue. (PubMed id 15586247)⁹ Remmelink M....Decaestecker C. (2005)
134. Comparative proteomic analysis of esophageal squamous cell carcinoma. (PubMed id 15986332)⁹ Qi Y....He Q.Y. (2005)
135. Selectivity of protein carbonylation in the apoptotic response to oxidative stress associated with photodynamic therapy: a cell biochemical and proteomic investigation. (PubMed id 15088069)⁹ Magi B....Di Stefano A. (2004)

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