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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBA3E Gene

protein-coding   GIFtS: 50
GCID: GC02M130949

Tubulin, Alpha 3e

  Search for TUBA3E
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin, Alpha 3e1 2
Alpha-Tubulin 3E2 3
Tubulin Alpha-3E Chain2

External Ids:    HGNC: 207651   Entrez Gene: 1127142   Ensembl: ENSG000001520867   UniProtKB: Q6PEY23   

Export aliases for TUBA3E gene to outside databases

Previous GC identifers: GC02M130666 GC02M123234


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TUBA3E Gene: 
TUBA3E (tubulin, alpha 3e) is a protein-coding gene. Among its related super-pathways are Development Slit-Robo signaling and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA3E_HUMAN, Q6PEY2
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)

summary for TUBA3E Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBA3E gene promoter:
         Sox5   Sp1   NRSF form 1   CUTL1   XBP-1   NRSF form 2   Arnt   E47   Roaz   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBA3E promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBA3E

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA3E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

TUBA3E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA3E gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M130949:  view genomic region     (about GC identifiers)

Start:
130,949,318 bp from pter      End:
130,956,034 bp from pter
Size:
6,717 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBA3E_HUMAN, Q6PEY2 (See protein sequence)
Recommended Name: Tubulin alpha-3E chain  
Size: 450 amino acids; 49859 Da
Subunit: Dimer of alpha and beta chains (By similarity)
Subcellular location: Cytoplasm, cytoskeleton (By similarity)

Explore the universe of human proteins at neXtProt for TUBA3E: NX_Q6PEY2

Explore proteomics data for TUBA3E at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue
    by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By
    similarity)
  • UniProtKB: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)
  • UniProtKB: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule
    motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle
    progression or cell differentiation to intracellular trafficking and signaling (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6PEY2

  • TUBA3E Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUBA3E Protein Expression
    REFSEQ proteins: NP_997195.1  
    ENSEMBL proteins: 
     ENSP00000318197  

    Human Recombinant Protein Products for TUBA3E: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005881cytoplasmic microtubule ----
    GO:0015630microtubule cytoskeleton IDA--
    GO:0043234protein complex ----

    TUBA3E for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TUB: Tubulins

    5/7 InterPro protein domains (see all 7):
     IPR002452 Alpha_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry Q6PEY2

    ProtoNet protein and cluster: Q6PEY2

    1 Blocks protein domain: IPB002452 Alpha tubulin signature

    UniProtKB/Swiss-Prot: TBA3E_HUMAN, Q6PEY2
    Similarity: Belongs to the tubulin family


    TUBA3E for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBA3E_HUMAN, Q6PEY2
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005525GTP binding IEA--
         
    TUBA3E for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TUBA3E:
     Cell division defect  Decreased cell number, increas  Decreased viability of wild-ty  Increased cell number in G2M,  
     Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUBA3E 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TUBA3E

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBA3E 
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    miRNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA3E


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUBA3E About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Pathogenic Escherichia coli infection0.43
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    Regulation of CFTR activity (norm and CF)0.38
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)0.38
    4Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94
    5Neurophysiological process Receptor-mediated axon growth repulsion
    Neurophysiological process Receptor-mediated axon growth repulsion0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/10 GeneGo (Thomson Reuters) Pathways for TUBA3E (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBA3E
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection



    3         Kegg Pathways  (Kegg details for TUBA3E):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection


    TUBA3E for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUBA3E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/613 Interacting proteins for TUBA3E (Q6PEY22, 3 ENSP000003181974) via UniProtKB, MINT, STRING, and/or I2D (see all 613)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237335O152123, ENSP000004123194I2D: score=2 STRING: ENSP00000412319
    PFDN6O152123, ENSP000003637344I2D: score=2 STRING: ENSP00000363734
    ENSG00000206283O152123I2D: score=2 
    ENSG00000224782O152123I2D: score=2 
    ENSG00000235692O152123I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0006184GTP catabolic process ----
    GO:0007017microtubule-based process IEA--
    GO:0051258protein polymerization IEA--

    TUBA3E for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TUBA3E available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 HMDB Compound for TUBA3E    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about TUBA3E / TBA3E

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUBA3E gene: 
    NM_207312.2  

    Unigene Cluster for TUBA3E:

    Tubulin, alpha 3e
    Hs.433336  [show with all ESTs]
    Unigene Representative Sequence: BC057811
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312988(uc002tqv.3)
    miRNA
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    Additional mRNA sequence: 

    AK131043.1 BC057811.1 

    3 DOTS entries:

    DT.101980613  DT.99992113  DT.86993860 

    24/27 AceView cDNA sequences (see all 27):

    BG722455 BG720572 BG722138 BI562424 BX282342 BI559662 BG704041 AI016802 
    AK131043 NM_207312 BG722213 BG721652 BC057811 BV196273 BV204612 BV204607 
    BG717561 BV204609 BV204611 AA977217 T19364 BX106685 AA397983 T19365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBA3E expression in normal human tissues (normalized intensities)      TUBA3E embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TUBA3E Expression
    About this image


    TUBA3E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Inner Cell Mass (Early Embryonic Tissues)
             Sox17-GFP genetically modified stem cells
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)

    See TUBA3E Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.433336
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA3E

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TUBA3E gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tuba3a5
    Tuba3b1
    tubulin, alpha 3A5
    tubulin, alpha 3B1
    90.3(n)1
    98.89(a)1
      6 (59.32 cM)5
    221471  NM_009449.31  NP_033475.11 
     1252782745 
    chicken
    (Gallus gallus)
    Aves TUBA3E6
    TUBA4A6
    Uncharacterized protein
    98(a)
    85(a)
    1 ↔ many
    possible ortholog
    9(23399168-23405755)
    1(1149164-1155872)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    99(a)
    83(a)
    possible ortholog
    possible ortholog
    3(28270544-28277986)
    GL343728.1(206949-228911)
    zebrafish
    (Danio rerio)
    Actinopterygii tuba8l41 tubulin, alpha 8 like 4 81.7(n)
    94.22(a)
      393154  NM_200185.1  NP_956479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaTub84D6
    alphaTub84B6
    (see all 3)
    alpha-Tubulin at 84B
    (see all 3)
    96(a)
    96(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(3356478-3358454)
    3R(2912321-2914561)
    worm
    (Caenorhabditis elegans)
    Secernentea tba-26
    tba-16
    (see all 7)
    Protein TBA-1, isoform b
    (see all 7)
    86(a)
    84(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    I(12964679-12966876)
    I(9785778-9787624)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB16
    TUB36
    Alpha-tubulin; associates with beta-tubulin (Tub2p...
    Alpha-tubulin; associates with beta-tubulin (Tub2p...
    73(a)
    72(a)
    many ↔ many
    many ↔ many
    XIII(97941-99400)
    XIII(22048-23683)


    ENSEMBL Gene Tree for TUBA3E (if available)
    TreeFam Gene Tree for TUBA3E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBA3E gene
    TUBA3C2  TUBA4A2  TUBA1C2  TUBA3D2  TUBA1B2  TUBAL32  TUBA1A2  TUBA82  
    18/29 SIMAP similar genes for TUBA3E using alignment to 1 protein entry:     TBA3E_HUMAN(see all similar genes):
    TUBA2    TUBA3C    TUBA3D    TUBA1A    TUBA4A    TUBA1
    DKFZp686L04275    TUBA8    TUBA4B    TUBA1B    TUBA1C    TUBAL3
    MGC16703    TUBB2A    TUBB2B    TUBB3    TUBB4Q    XTP3TPATP1

    TUBA3E for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TUBA3E
    PGOHUM00000235213


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 SNPs in TUBA3E are shown (see all 104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0526694
    ----see VAR_0526692 W R mis40--------
    VAR_0546404
    ----see VAR_0546402 S G mis40--------
    VAR_0526674
    ----see VAR_0526672 S N mis40--------
    VAR_0546414
    ----see VAR_0546412 A E mis40--------
    VAR_0526684
    ----see VAR_0526682 A V mis40--------
    rs10524561,2
    --130949462(-) GGATTG/ATGAAG 2 /Y /C mis1 ese31Minor allele frequency- A:0.00NA 2
    rs26955161,2
    A--130949729(+) AGTCCA/GTGAAG 1 -- int10--------
    rs346283691,2
    C--130950663(+) AAAATA/-TACCC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs74262841,2
    C--130952985(+) ATGCAA/GTTTAT 1 -- int10--------
    rs130078121,2
    C--130953018(+) CTTGTG/TGTATA 1 -- int11Minor allele frequency- T:0.50WA 2

    HapMap Linkage Disequilibrium report for TUBA3E (130949318 - 130956034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/28 variations for TUBA3E (see all 28):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2720767CNV Deletion23290073
    esv2661150CNV Deletion23128226
    nsv834375CNV Loss17160897
    esv27317CNV Loss19812545
    nsv459274CNV Loss19166990
    nsv428403CNV Loss18775914
    nsv821629CNV Loss15273396
    nsv10165CNV Loss18304495
    dgv4306n71CNV Gain21882294
    dgv475n27CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBA3E gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with TUBA3E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    2. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    3. SGTA recognizes a noncanonical ubiquitin-like domain i n the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degra dation. (PubMed id 23246001)1 Xu Y....Ye Y. (2012)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Viral immune modulators perturb the human molecular ne twork by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (2012)
    6. Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715)1 Lai Y....Shiio Y. (2011)
    7. Integrative analysis of the ubiquitin proteome isolat ed using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (2011)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 112714 HGNC: 20765 AceView: LOC112714 Ensembl:ENSG00000152086 euGenes: HUgn112714
    ECgene: TUBA3E Kegg: 112714 H-InvDB: TUBA3E

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBA3E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUBA3E gene:
    Search GeneIP for patents involving TUBA3E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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