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TUBA3E Gene

protein-coding   GIFtS: 51
GCID: GC02M130949

Tubulin, Alpha 3e

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Alpha 3e1 2
Alpha-Tubulin 3E2 3
Tubulin Alpha-3E Chain2

External Ids:    HGNC: 207651   Entrez Gene: 1127142   Ensembl: ENSG000001520867   UniProtKB: Q6PEY23   

Export aliases for TUBA3E gene to outside databases

Previous GC identifers: GC02M130666 GC02M123234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TUBA3E Gene:
TUBA3E (tubulin, alpha 3e) is a protein-coding gene. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA3E_HUMAN, Q6PEY2
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)

summary for TUBA3E Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBA3E gene promoter:
         Sox5   Sp1   NRSF form 1   CUTL1   XBP-1   NRSF form 2   Arnt   E47   Roaz   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBA3E promoter sequence
   Search Chromatin IP Primers for TUBA3E

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBA3E


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

TUBA3E Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA3E gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M130949:  view genomic region     (about GC identifiers)

Start:
130,949,318 bp from pter      End:
130,956,034 bp from pter
Size:
6,717 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TBA3E_HUMAN, Q6PEY2 (See protein sequence)
Recommended Name: Tubulin alpha-3E chain  
Size: 450 amino acids; 49859 Da
Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer
diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form
protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule
plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and specialized cells

Explore the universe of human proteins at neXtProt for TUBA3E: NX_Q6PEY2

Explore proteomics data for TUBA3E at MOPED

Post-translational modifications: 

  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue
    by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By
    similarity)1
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule
    motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle
    progression or cell differentiation to intracellular trafficking and signaling (By similarity)1
  • Ubiquitination2 at Lys60, Lys280, Lys304, Lys326, Lys336, Lys338, Lys352, Lys370
  • Glycosylation2 at Asn380
  • Modification sites at PhosphoSitePlus

  • See TUBA3E Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997195.1  
    ENSEMBL proteins: 
     ENSP00000318197  

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    antibodies-online proteins for TUBA3E (3 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 7):
     IPR002452 Alpha_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry Q6PEY2

    ProtoNet protein and cluster: Q6PEY2

    1 Blocks protein domain: IPB002452 Alpha tubulin signature

    UniProtKB/Swiss-Prot: TBA3E_HUMAN, Q6PEY2
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBA3E           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBA3E_HUMAN, Q6PEY2
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005525GTP binding IEA--
    GO:0019904protein domain specific binding ----
         
    Find genes that share ontologies with TUBA3E           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TUBA3E:
     Cell division defect  Decreased cell number, increas  Decreased viability of wild-ty  Increased cell number in G2M,  
     Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TUBA3E

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBA3E_HUMAN, Q6PEY2: Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol3
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule IEA--
    GO:0005881cytoplasmic microtubule ----
    GO:0015630microtubule cytoskeleton ----
    GO:0043234protein complex ----

    Find genes that share ontologies with TUBA3E           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBA3E About    
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Pathogenic Escherichia coli infection0.43
    2Regulation of CFTR activity norm and CF
    Regulation of CFTR activity norm and CF 0.38
    wtCFTR and deltaF508 traffic Membrane expression norm and CF 0.38
    3Parkin-Ubiquitin Proteasomal System pathway
    Parkin-Ubiquitin Proteasomal System pathway0.89
    4Signaling in Gap Junctions
    Gap junction0.31
    5Phagosome
    Phagosome


    Find genes that share SuperPaths with TUBA3E           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for TUBA3E (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBA3E
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection



    3 Kegg Pathways  (Kegg details for TUBA3E):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBA3E
    Interactions:

        Search GeneGlobe Interaction Network for TUBA3E

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBA3E (Q6PEY22, 3 ENSP000003181974) via UniProtKB, MINT, STRING, and/or I2D (see all 652)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237335O152123, ENSP000004123194I2D: score=2 STRING: ENSP00000412319
    PFDN6O152123, ENSP000003637344I2D: score=2 STRING: ENSP00000363734
    ENSG00000206283O152123I2D: score=2 
    ENSG00000224782O152123I2D: score=2 
    ENSG00000235692O152123I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0006184GTP catabolic process ----
    GO:0007017microtubule-based process IEA--
    GO:0008150biological_process ND--
    GO:0051258protein polymerization IEA--

    Find genes that share ontologies with TUBA3E           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TUBA3E available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 HMDB Compound for TUBA3E    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TUBA3E gene: 
    NM_207312.2  

    Unigene Cluster for TUBA3E:

    Tubulin, alpha 3e
    Hs.433336  [show with all ESTs]
    Unigene Representative Sequence: BC057811
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312988(uc002tqv.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat TUBA3E

    Additional mRNA sequence: 

    AK131043.1 BC057811.1 

    3 DOTS entries:

    DT.101980613  DT.99992113  DT.86993860 

    Selected AceView cDNA sequences (see all 27):

    BG720572 BG704041 BI559662 BG722138 BG722455 BG722213 NM_207312 AI016802 
    BI562424 BX282342 BG721652 AK131043 BC057811 BV196273 BX106685 AA397983 
    AA977217 BV204609 T19364 BV204607 BV204611 BV204612 BG717561 T19365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBA3E expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TUBA3E Expression
    About this image


    TUBA3E expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             XX Germ Cells Ovigerous Cord
     
     Gonad
             XX Germ Cells Ovigerous Cord
     
     Testis (Reproductive System)
    TUBA3E Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBA3E Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.433336
        Custom PCR Arrays for TUBA3E
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TUBA3E gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tuba3a5
    Tuba3b1
    tubulin, alpha 3A5
    tubulin, alpha 3B1
    90.3(n)1
    98.89(a)1
      6 (59.32 cM)5
    221471  NM_009449.31  NP_033475.11 
     1252782745 
    chicken
    (Gallus gallus)
    Aves LOC4250491 tubulin alpha-3 chain-like 81.33(n)
    98(a)
      425049  XM_422851.4  XP_422851.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    99(a)
    1 → many
    3(28270544-28277986)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tuba3c1 tubulin, alpha 3c 77.8(n)
    94.09(a)
      548688  NM_001015934.3  NP_001015934.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7955911 tubulin alpha-1A chain-like 82.8(n)
    96.36(a)
      795591  XM_003198748.2  XP_003198796.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaTub85E1 alpha-Tubulin at 85E 82(n)
    94.99(a)
      41183  NM_079573.4  NP_524297.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mec-121 mec-12 73.86(n)
    91.59(a)
      175419  NM_065262.5  NP_497663.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB16
    Alpha-tubulin; associates with beta-tubulin (Tub2p...
    73(a)
    1 → many
    XIII(97941-99400) YML085C


    ENSEMBL Gene Tree for TUBA3E (if available)
    TreeFam Gene Tree for TUBA3E (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBA3E gene
    TUBA3C2  TUBA4A2  TUBA1B2  TUBA1A2  TUBA1C2  TUBA82  TUBA3D2  
    Selected SIMAP similar genes for TUBA3E using alignment to 1 protein entry:     TBA3E_HUMAN(see all similar genes):
    TUBA2    TUBA3C    TUBA3D    TUBA1A    TUBA4A    TUBA1
    DKFZp686L04275    TUBA8    TUBA4B    TUBA1B    TUBA1C    TUBAL3
    MGC16703    TUBB2A    TUBB2B    TUBB3    TUBB4Q    XTP3TPATP1

    Find genes that share paralogs with TUBA3E           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TUBA3E
    PGOHUM00000235213


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBA3E (see all 104)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10524561,2
    --130949462(-) GGATTG/ATGAAG 2 /Y /C mis1 ese31Minor allele frequency- A:0.00NA 2
    rs26955161,2
    A--130949729(+) AGTCCA/GTGAAG 1 -- int10--------
    rs346283691,2
    C--130950663(+) AAAATA/-TACCC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs74262841,2
    C--130952985(+) ATGCAA/GTTTAT 1 -- int10--------
    rs130078121,2
    C--130953018(+) CTTGTG/TGTATA 1 -- int11Minor allele frequency- T:0.50WA 2
    rs74195651,2
    C,F,A,H--130953022(+) TGGTAC/TAAATG 1 -- int128Minor allele frequency- N:0.00EA NA NS WA CSA 2962
    rs101747591,2
    C,H--130953080(+) ACTCAG/TGTACA 1 -- int14Minor allele frequency- T:0.00NS EA 408
    rs24436461,2
    C,F,H--130953371(+) ACTCTC/AGTGCA 1 -- int113Minor allele frequency- A:0.42NS EA NA 1970
    rs1899317201,2
    --130953372(+) CTCTCC/GTGCAC 1 -- int10--------
    rs1930442161,2
    --130953389(+) AAGAGA/CATGCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TUBA3E (130949318 - 130956034 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TUBA3E (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720767CNV Deletion23290073
    esv2661150CNV Deletion23128226
    nsv834375CNV Loss17160897
    esv27317CNV Loss19812545
    nsv459274CNV Loss19166990
    nsv428403CNV Loss18775914
    nsv821629CNV Loss15273396
    nsv10165CNV Loss18304495
    dgv4306n71CNV Gain21882294
    dgv475n27CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBA3E
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBA3E gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TUBA3E)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    2. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    3. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    4. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). (PubMed id 22178446)1 Lopitz-Otsoa F....Rodriguez M.S. (J Proteomics 2012)
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    6. Viral immune modulators perturb the human molecular network by common and unique strategies. (PubMed id 22810585)1 Pichlmair A....Superti-Furga G. (Nature 2012)
    7. Proteomic dissection of the von Hippel-Lindau (VHL) interactome. (PubMed id 21942715)1 Lai Y....Shiio Y. (J. Proteome Res. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112714 HGNC: 20765 AceView: LOC112714 Ensembl:ENSG00000152086 euGenes: HUgn112714
    ECgene: TUBA3E Kegg: 112714 H-InvDB: TUBA3E

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TUBA3E Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TUBA3E gene:
    Search GeneIP for patents involving TUBA3E

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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