External Ids for TUBA3E Gene
Previous GeneCards Identifiers for TUBA3E Gene
GeneCards Summary for TUBA3E Gene
TUBA3E (Tubulin Alpha 3e) is a Protein Coding gene. Diseases associated with TUBA3E include Congenital Nervous System Abnormality and Periventricular Nodular Heterotopia. Among its related pathways are Regulation of CFTR activity (norm and CF) and Phagosome. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA4B.
UniProtKB/Swiss-Prot for TUBA3E Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).