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Aliases for TUBA3E Gene

Aliases for TUBA3E Gene

  • Tubulin, Alpha 3e 2 3
  • Alpha-Tubulin 3E 4

External Ids for TUBA3E Gene

Previous GeneCards Identifiers for TUBA3E Gene

  • GC02M130666
  • GC02M130949
  • GC02M123234

Summaries for TUBA3E Gene

GeneCards Summary for TUBA3E Gene

TUBA3E (Tubulin, Alpha 3e) is a Protein Coding gene. Among its related pathways are EphB-EphrinB Signaling and Development Slit-Robo signaling. GO annotations related to this gene include GTP binding and structural constituent of cytoskeleton. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot for TUBA3E Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Tocris Summary for TUBA3E Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

No data available for Entrez Gene Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA3E Gene

Genomics for TUBA3E Gene

Regulatory Elements for TUBA3E Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TUBA3E Gene

Start:
130,191,743 bp from pter
End:
130,198,461 bp from pter
Size:
6,719 bases
Orientation:
Minus strand

Genomic View for TUBA3E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBA3E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA3E Gene

Proteins for TUBA3E Gene

  • Protein details for TUBA3E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEY2-TBA3E_HUMAN
    Recommended name:
    Tubulin alpha-3E chain
    Protein Accession:
    Q6PEY2
    Secondary Accessions:

    Protein attributes for TUBA3E Gene

    Size:
    450 amino acids
    Molecular mass:
    49859 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells

neXtProt entry for TUBA3E Gene

Proteomics data for TUBA3E Gene at MOPED

Post-translational modifications for TUBA3E Gene

  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Ubiquitination at Lys60, Lys280, Lys304, Lys326, Lys336, Lys338, Lys352, and Lys370
  • Glycosylation at Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBA3E Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TUBA3E Gene

Domains for TUBA3E Gene

Gene Families for TUBA3E Gene

HGNC:
  • TUB :Tubulins

Suggested Antigen Peptide Sequences for TUBA3E Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PEY2

UniProtKB/Swiss-Prot:

TBA3E_HUMAN :
  • Q6PEY2
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA3E: view

Function for TUBA3E Gene

Molecular function for TUBA3E Gene

UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).

Gene Ontology (GO) - Molecular Function for TUBA3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBA3E: view
genes like me logo Genes that share phenotypes with TUBA3E: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA3E

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TUBA3E Gene

Localization for TUBA3E Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA3E Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBA3E Gene COMPARTMENTS Subcellular localization image for TUBA3E gene
Compartment Confidence
cytoskeleton 4
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBA3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with TUBA3E: view

Pathways for TUBA3E Gene

genes like me logo Genes that share pathways with TUBA3E: view

Gene Ontology (GO) - Biological Process for TUBA3E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0007017 microtubule-based process IEA --
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
GO:0051258 protein polymerization IEA --
genes like me logo Genes that share ontologies with TUBA3E: view

Compounds for TUBA3E Gene

(5) Tocris Compounds for TUBA3E Gene

Compound Action Cas Number
ABT 751 Inhibitor of microtubule polymerization; antimitotic and antitumor [141430-65-1]
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Harmine Potent and selective Dyrk1A inhibitor [442-51-3]
Vinblastine sulfate Disrupts microtubules [143-67-9]

(1) HMDB Compounds for TUBA3E Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with TUBA3E: view

Transcripts for TUBA3E Gene

mRNA/cDNA for TUBA3E Gene

(27) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TUBA3E Gene

Tubulin, alpha 3e:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA3E

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TUBA3E
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA3E Gene

No ASD Table

Relevant External Links for TUBA3E Gene

GeneLoc Exon Structure for
TUBA3E
ECgene alternative splicing isoforms for
TUBA3E

Expression for TUBA3E Gene

mRNA expression in normal human tissues for TUBA3E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TUBA3E Gene

This gene is overexpressed in Testis (33.6) and Heart - Left Ventricle (13.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBA3E Gene

SOURCE GeneReport for Unigene cluster for TUBA3E Gene Hs.433336

genes like me logo Genes that share expressions with TUBA3E: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TUBA3E Gene

Orthologs for TUBA3E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TUBA3E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBA3E 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBA3E 35
  • 89.41 (n)
  • 98.89 (a)
TUBA3E 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 98 (a)
ManyToMany
LOC608051 35
  • 92.74 (n)
  • 98.89 (a)
mouse
(Mus musculus)
Mammalia Tuba3a 16
Tuba3a 36
  • 99 (a)
OneToOne
Tuba3b 35
  • 90.3 (n)
  • 98.89 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tuba3b 35
  • 90.89 (n)
  • 98.89 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 98 (a)
OneToMany
LOC425049 35
  • 81.33 (n)
  • 98 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 99 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tuba3c 35
  • 77.8 (n)
  • 94.09 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC795591 35
  • 82.8 (n)
  • 96.36 (a)
tuba8l3 36
  • 94 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001219 35
  • 82.46 (n)
  • 97.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta alphaTub84D 36
  • 96 (a)
ManyToMany
alphaTub85E 35
  • 82 (n)
  • 94.99 (a)
worm
(Caenorhabditis elegans)
Secernentea mec-12 35
  • 73.86 (n)
  • 91.59 (a)
tba-4 36
  • 84 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB1 36
  • 73 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11340 36
  • 96 (a)
OneToMany
Species with no ortholog for TUBA3E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBA3E Gene

ENSEMBL:
Gene Tree for TUBA3E (if available)
TreeFam:
Gene Tree for TUBA3E (if available)

Paralogs for TUBA3E Gene

Paralogs for TUBA3E Gene

Pseudogenes.org Pseudogenes for TUBA3E Gene

genes like me logo Genes that share paralogs with TUBA3E: view

Variants for TUBA3E Gene

Sequence variations from dbSNP and Humsavar for TUBA3E Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1052310 -- 130,194,020(-) GCCCC(A/G)GTCAT reference, synonymous-codon
rs1052312 -- 130,194,008(-) TCAGC(C/T)GAGAA synonymous-codon, reference
rs1052319 -- 130,193,975(-) GTGGC(C/T)GAGAT reference, synonymous-codon
rs1052421 -- 130,192,009(-) CCTGG(A/T)CCATA missense, reference
rs1052422 - 130,191,980(-) CCAAG(C/T)GGGCC missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TUBA3E Gene

Variant ID Type Subtype PubMed ID
nsv821629 CNV Loss 15273396
nsv459274 CNV Loss 19166990
dgv1247e1 CNV Complex 17122850
esv2751826 CNV Gain 17911159
dgv1249e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
dgv4305n71 CNV Gain 21882294
dgv4306n71 CNV Gain 21882294
essv1878 CNV CNV 17122850
nsv875061 CNV Gain 21882294
nsv834375 CNV Loss 17160897
nsv7327 OTHER Inversion 18451855
nsv875074 CNV Gain 21882294
dgv4307n71 CNV Gain 21882294
nsv520559 CNV Gain+Loss 19592680
nsv875084 CNV Gain+Loss 21882294
nsv875086 CNV Gain 21882294
nsv875087 CNV Gain 21882294
dgv4308n71 CNV Gain 21882294
nsv470485 CNV Gain 18288195
nsv818080 CNV Gain 17921354
dgv475n27 CNV Gain 19166990
essv2399 CNV CNV 17122850
esv27317 CNV Loss 19812545
nsv10165 CNV Loss 18304495
esv2720767 CNV Deletion 23290073
esv2661150 CNV Deletion 23128226

Relevant External Links for TUBA3E Gene

HapMap Linkage Disequilibrium report
TUBA3E
Human Gene Mutation Database (HGMD)
TUBA3E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBA3E Gene

Disorders for TUBA3E Gene

No disorders were found for TUBA3E Gene.

No data available for UniProtKB/Swiss-Prot for TUBA3E Gene

Publications for TUBA3E Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. HIV-1 Tat protein enhances microtubule polymerization. (PMID: 15691386) de Mareuil J. … Loret E.P. (Retrovirology 2005) 3
  3. HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? (PMID: 15698476) Giacca M. (Retrovirology 2005) 3
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for TUBA3E Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TUBA3E
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA3E
    • Block miRNA regulation of TUBA3E using miScript Target Protectors
    • antibodies-online proteins for TUBA3E
    • antibodies-online antibodies for TUBA3E
    • antibodies-online kits for TUBA3E

    Sources for TUBA3E Gene

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