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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBA3D Gene

protein-coding   GIFtS: 52
GCID: GC02P132233

Tubulin, Alpha 3d

Alzheimer's & Parkinson's Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin, Alpha 3d1 2     Tubulin Alpha-3C/D Chain2
Alpha-Tubulin Isotype H2-Alpha1 2     TUBA23
Tubulin Alpha-2 Chain2 3     Alpha-Tubulin 23
H2-ALPHA2     Alpha-Tubulin 3C/D3

External Ids:    HGNC: 240711   Entrez Gene: 1134572   Ensembl: ENSG000000758867   UniProtKB: Q137483   

Export aliases for TUBA3D gene to outside databases

Previous GC identifers: GC02P131952 GC02P124227


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TUBA3D Gene:
This gene encodes a member of the alpha tubulin family. Tubulin is a major component of microtubules, which are
composed of alpha- and beta-tubulin heterodimers and microtubule-associated proteins in the cytoskeleton.
Microtubules maintain cellular structure, function in intracellular transport, and play a role in spindle
formation during mitosis. (provided by RefSeq, Oct 2011)

GeneCards Summary for TUBA3D Gene: 
TUBA3D (tubulin, alpha 3d) is a protein-coding gene. Diseases associated with TUBA3D include alzheimer's disease, and among its related super-pathways are Development Slit-Robo signaling and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA3C_HUMAN, Q13748
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA3D Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBA3D gene promoter:
         Sox5   AML1a   Sp1   NRSF form 1   XBP-1   CUTL1   NRSF form 2   E47   Arnt   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBA3D promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBA3D

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA3D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1   Ensembl cytogenetic band:  2q21.1   HGNC cytogenetic band: 2q21.1

TUBA3D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA3D gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P132233:  view genomic region     (about GC identifiers)

Start:
132,233,666 bp from pter      End:
132,240,507 bp from pter
Size:
6,842 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBA3C_HUMAN, Q13748 (See protein sequence)
Recommended Name: Tubulin alpha-3C/D chain  
Size: 450 amino acids; 49960 Da
Subunit: Dimer of alpha and beta chains
Subcellular location: Cytoplasm, cytoskeleton
Secondary accessions: A6NJQ0 Q5W099 Q6PEY3 Q96F18
Alternative splicing: 2 isoforms:  Q13748-1   Q13748-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TUBA3D: NX_Q13748

Explore proteomics data for TUBA3D at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue
    by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By
    similarity)
  • UniProtKB: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)
  • UniProtKB: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule
    motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle
    progression or cell differentiation to intracellular trafficking and signaling (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13748

  • TUBA3D Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUBA3D Protein Expression
    REFSEQ proteins: NP_525125.2  
    ENSEMBL proteins: 
     ENSP00000326042  
    Reactome Protein details: Q13748
    Human Recombinant Protein Products for TUBA3D: 
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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule NAS--
    GO:0005881cytoplasmic microtubule ----
    GO:0015630microtubule cytoskeleton IDA--
    GO:0043234protein complex ----

    TUBA3D for ontologies           About GeneDecksing



    TUBA3D Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TUB: Tubulins

    5/7 InterPro protein domains (see all 7):
     IPR002452 Alpha_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry Q13748

    ProtoNet protein and cluster: Q13748

    1 Blocks protein domain: IPB002452 Alpha tubulin signature

    UniProtKB/Swiss-Prot: TBA3C_HUMAN, Q13748
    Similarity: Belongs to the tubulin family


    TUBA3D for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBA3C_HUMAN, Q13748
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding NAS--
         
    TUBA3D for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TUBA3D 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBA3D 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUBA3D About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    Cytoplasmic microtubules0.32
    4wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
    wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)0.38
    Regulation of CFTR activity (norm and CF)0.38
    5Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Reverse signaling by ephrin B0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for TUBA3D (see all 9)
        Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Slit-Robo signaling
    Cytoplasmic microtubules
    Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Keratin filaments


    5/10 GeneGo (Thomson Reuters) Pathways for TUBA3D (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBA3D
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection


    5/38        Reactome Pathways for TUBA3D (see all 38)
        L1CAM interactions
    Mitotic Prometaphase
    Membrane Trafficking
    Protein folding
    Recruitment of mitotic centrosome proteins and complexes


    3         Kegg Pathways  (Kegg details for TUBA3D):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection


    TUBA3D for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUBA3D

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/82 Interacting proteins for TUBA3D (Q137481, 2, 3 ENSP000003260424) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NMIQ132871, 3, ENSP000002433464EBI-355068,EBI-372942 I2D: score=5 STRING: ENSP00000243346
    CHUKO151112, 3, ENSP000003594244MINT-48061 I2D: score=2 STRING: ENSP00000359424
    NFKB2Q006532, 3MINT-48763 MINT-48622 I2D: score=2 
    TAB1Q157502, 3, ENSP000002161604MINT-49179 I2D: score=2 STRING: ENSP00000216160
    NFKB1P198382, 3MINT-48558 MINT-48683 I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0006184GTP catabolic process ----
    GO:0006457protein folding TAS--
    GO:0007017microtubule-based process NAS--
    GO:0044267cellular protein metabolic process TAS--

    TUBA3D for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TUBA3D available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    Search CenterWatch for drugs/clinical trials and news about TUBA3D / TBA3C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TUBA3D gene: 
    NM_080386.3  

    Unigene Cluster for TUBA3D:

    Tubulin, alpha 3d
    Hs.503749  [show with all ESTs]
    Unigene Representative Sequence: NM_080386
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321253(uc002tsu.4) ENST00000409047

    miRNA
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    Additional mRNA sequence: 

    AK093116.1 AK292253.1 BC057810.1 

    6 DOTS entries:

    DT.101980613  DT.86993860  DT.99992113  DT.100752333  DT.120981136  DT.101961241 

    24/28 AceView cDNA sequences (see all 28):

    T31971 AX747933 BC057810 AK093116 AI028577 BI462670 AL042663 BG724164 
    BG723217 BI596415 BG704041 BG773507 AL044269 BX106685 C04130 BV204611 
    BV204607 AA626698 C02960 BV204609 AA435720 AA770436 BV204612 AW966211 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBA3D expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGAGGGAG
    TUBA3D Expression
    About this image


    See TUBA3D Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUBA3D

    SOURCE GeneReport for Unigene cluster: Hs.503749

    UniProtKB/Swiss-Prot: TBA3C_HUMAN, Q13748
    Tissue specificity: Testis specific

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA3D

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TUBA3D gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TUBA3E1 tubulin, alpha 3e 81.56(n)
    99.11(a)
      425049  XM_422851.3  XP_422851.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    --
    84(a)
    100(a)
    possible ortholog
    1 ↔ many
    GL343728.1(206949-228911)
    3(28270544-28277986)
    zebrafish
    (Danio rerio)
    Actinopterygii tuba7l1 tubulin, alpha 7 like 81.14(n)
    95.1(a)
      431777  NM_001002230.1  NP_001002230.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaTub84B6
    alphaTub84D6
    (see all 3)
    alpha-Tubulin at 84D
    (see all 3)
    98(a)
    97(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    3R(2912321-2914561)
    3R(3356478-3358454)
    worm
    (Caenorhabditis elegans)
    Secernentea tba-26
    tba-16
    (see all 7)
    Protein TBA-1, isoform b
    (see all 7)
    87(a)
    86(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    I(12964679-12966876)
    I(9785778-9787624)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB16
    TUB36
    Alpha-tubulin; associates with beta-tubulin (Tub2p...
    Alpha-tubulin; associates with beta-tubulin (Tub2p...
    74(a)
    73(a)
    many ↔ many
    many ↔ many
    XIII(97941-99400)
    XIII(22048-23683)
            Species with no ortholog for TUBA3D

    ENSEMBL Gene Tree for TUBA3D (if available)
    TreeFam Gene Tree for TUBA3D (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBA3D gene
    TUBA3C1 2  TUBA4A2  TUBA1B2  TUBA1A2  TUBAL32  TUBA3E2  TUBA1C2  TUBA82  
    18/27 SIMAP similar genes for TUBA3D using alignment to 1 protein entry:     TBA3C_HUMAN(see all similar genes):
    TUBA2    TUBA1A    TUBA3E    TUBA4A    DKFZp686L04275    TUBA8
    TUBA4B    TUBAL3    TUBA1C    TUBA1B    MGC16703    TUBB2A
    TUBB2B    TUBB3    TUBB4Q    DKFZp566F223    TUBB1    TUBB2C

    TUBA3D for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/336 SNPs in TUBA3D are shown (see all 336)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs748433591,2
    F--124226830(+) AGAGGA/GGCAGG 1 -- us2k12Minor allele frequency- G:0.33NA 6
    rs788131021,2
    C--124227846(+) GTGGTA/TCCAGC 1 -- int10--------
    rs25999951,2
    --124228866(+) GCTACA/TTATTC 1 -- int10--------
    rs26219981,2
    --124228923(-) GCCATG/TTAATG 1 -- int10--------
    rs26219971,2
    --124228986(-) CTAGAA/GGTAGC 1 -- int10--------
    rs26219961,2
    --124229173(-) ATAAAA/TGTGAA 1 -- int10--------
    rs26955191,2
    --124229184(-) TGAACA/CGGAAC 1 -- int10--------
    rs25999961,2
    --124229291(+) GATGGC/TCAAAT 3 G syn10--------
    rs756567521,2
    C--124229766(+) TGCACG/TAGAGT 1 -- int11Minor allele frequency- T:0.00NA 2
    rs24436451,2
    C--124229843(-) ACTACC/ATCAGG 1 -- int11Minor allele frequency- A:0.50NA 2

    HapMap Linkage Disequilibrium report for TUBA3D (132233666 - 132240507 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/27 variations for TUBA3D (see all 27):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670824CNV Deletion23128226
    nsv428404CNV Loss18775914
    nsv10183CNV Loss18304495
    dgv4312n71CNV Loss21882294
    dgv476n27CNV Loss19166990
    nsv875120CNV Loss21882294
    nsv470486CNV Loss18288195
    nsv524021CNV Loss19592680
    nsv459396CNV Gain19166990
    dgv4313n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TUBA3D:    About MalaCards
    alzheimer's disease    


    TUBA3D for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for TUBA3D gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBA3D gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with TUBA3D)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis- specific expression of two sister genes. (PubMed id 3785200)1, 3 Villasante A.... Cowan N.J. (1986)
    2. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....Yanez-Mo M. (2013)
    3. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    4. SGTA recognizes a noncanonical ubiquitin-like domain i n the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degra dation. (PubMed id 23246001)1 Xu Y....Ye Y. (2012)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Proteomic dissection of the von Hippel-Lindau (VHL) i nteractome. (PubMed id 21942715)1 Lai Y....Shiio Y. (2011)
    7. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    8. Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity. (PubMed id 21167302)1 Yamamoto S.P....Suzuki Y. (2011)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113457 HGNC: 24071 AceView: H2-ALPHA Ensembl:ENSG00000075886 euGenes: HUgn113457
    ECgene: TUBA3D Kegg: 113457 H-InvDB: TUBA3D

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBA3D Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Tubulin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUBA3D gene:
    Search GeneIP for patents involving TUBA3D

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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