Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TUBA1C Gene

protein-coding   GIFtS: 64
GCID: GC12P049582

Tubulin, Alpha 1c

(Previous names: tubulin, alpha 6)
(Previous symbol: TUBA6)
  See TUBA1C-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tubulin, Alpha 1c1 2     Tubulin Alpha-6 Chain2 3
TUBA61 2 3     bcm9482
Tubulin, Alpha 61 2     Tubulin Alpha-1C Chain2
Alpha-Tubulin 62 3     

External Ids:    HGNC: 207681   Entrez Gene: 847902   Ensembl: ENSG000001675537   UniProtKB: Q9BQE33   
ORGUL members:         

Export aliases for TUBA1C gene to outside databases

Previous GC identifers: GC12P047908 GC12P049658 GC12P046689


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TUBA1C Gene:
TUBA1C (tubulin, alpha 1c) is a protein-coding gene. Diseases associated with TUBA1C include distal hereditary motor neuropathy, type ii, and osteoblastoma. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA1C Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBA1C gene promoter:
         HNF-1A   YY1   PPAR-gamma1   CBF-A   CBF-B   HNF-1   PPAR-gamma2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBA1C promoter sequence
   Search Chromatin IP Primers for TUBA1C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBA1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

TUBA1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA1C gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P049582:  view genomic region     (about GC identifiers)

Start:
49,582,519 bp from pter      End:
49,667,114 bp from pter
Size:
84,596 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 (See protein sequence)
Recommended Name: Tubulin alpha-1C chain  
Size: 449 amino acids; 49895 Da
Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer
diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form
protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule
plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and specialized cells

Explore the universe of human proteins at neXtProt for TUBA1C: NX_Q9BQE3

Explore proteomics data for TUBA1C at MOPED

Post-translational modifications: 

  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue
    by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By
    similarity)1
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule
    motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle
    progression or cell differentiation to intracellular trafficking and signaling (By similarity)1
  • Ubiquitination2 at Lys60, Lys96, Lys112, Lys163, Lys280, Lys304, Lys311, Lys326, Lys336, Lys338,
                                 Lys352, Lys370, Lys394, Lys401
  • Modification sites at PhosphoSitePlus

  • See TUBA1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116093.1  
    ENSEMBL proteins: 
     ENSP00000443475   ENSP00000447669   ENSP00000448646   ENSP00000447910   ENSP00000301072  
     ENSP00000448211  
    Reactome Protein details: Q9BQE3

    TUBA1C Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TUBA1C
    OriGene Protein Over-expression Lysate for TUBA1C
    OriGene MassSpec for TUBA1C
    OriGene Custom Protein Services for TUBA1C
    GenScript Custom Purified and Recombinant Proteins Services for TUBA1C
    Novus Biologicals TUBA1C Protein
    Novus Biologicals TUBA1C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for TUBA1C 

     
    antibodies-online proteins for TUBA1C (6 products) 

     
    antibodies-online peptides for TUBA1C

    TUBA1C Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TUBA1C
    OriGene Custom Antibody Services for TUBA1C
    Novus Biologicals TUBA1C Antibodies
    Abcam antibodies for TUBA1C (P68366, Q9BQE3)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for TUBA1C
    LSBio Antibodies in human, mouse, rat for TUBA1C
    antibodies-online antibodies for TUBA1C (49 products) 

    TUBA1C Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TUBA1C
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TUBA1C
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for TUBA1C 
    antibodies-online kits for TUBA1C (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 7):
     IPR002452 Alpha_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry Q9BQE3

    ProtoNet protein and cluster: Q9BQE3

    1 Blocks protein domain: IPB002452 Alpha tubulin signature

    UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3
    Similarity: Belongs to the tubulin family


    Find genes that share domains with TUBA1C           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBA1C_HUMAN, Q9BQE3
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005198structural molecule activity TAS12090300
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005525GTP binding IEA--
    GO:0019904protein domain specific binding ----
         
    Find genes that share ontologies with TUBA1C           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TUBA1C:
     Cell division defect  Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased viability of wild-ty 
     Increased gamma-H2AX phosphory  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBA1C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBA1C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TUBA1C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TUBA1C

    miRNA
    Products:
        
    miRTarBase miRNAs that target TUBA1C:
    hsa-let-7b-5p (MIRT052239), hsa-mir-324-5p (MIRT043045), hsa-mir-296-3p (MIRT038397), hsa-mir-16-5p (MIRT031663), hsa-mir-92a-3p (MIRT049110), hsa-mir-877-3p (MIRT036933), hsa-mir-760 (MIRT036769), hsa-mir-940 (MIRT036595), hsa-mir-221-3p (MIRT046865)

    Block miRNA regulation of human, mouse, rat TUBA1C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TUBA1C
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TUBA1C
    Predesigned siRNA for gene silencing in human, mouse, rat TUBA1C

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TUBA1C

    Clone
    Products:
         
    OriGene clones in human, mouse for TUBA1C (see all 7)
    OriGene ORF clones in mouse, rat for TUBA1C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704)
    Sino Biological Human cDNA Clone for TUBA1C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TUBA1C
    Browse ESI BIO Cell Lines and PureStem Progenitors for TUBA1C 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TBA1C_HUMAN, Q9BQE3: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005874microtubule TAS12090300
    GO:0005881cytoplasmic microtubule IEA--
    GO:0015630microtubule cytoskeleton ----
    GO:0043234protein complex ----

    Find genes that share ontologies with TUBA1C           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TUBA1C About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    4Protein folding
    Chaperonin-mediated protein folding0.91
    Post-chaperonin tubulin folding pathway0.00
    Protein folding0.91
    5Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Prefoldin mediated transfer of substrate to CCT/TriC0.72
    Formation of tubulin folding intermediates by CCT/TriC0.76


    Find genes that share SuperPaths with TUBA1C           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected GeneGo (Thomson Reuters) Pathways for TUBA1C (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    2 BioSystems Pathways for TUBA1C
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection


    13 Reactome Pathways for TUBA1C (see first 5)
        Resolution of Sister Chromatid Cohesion
    Prefoldin mediated transfer of substrate to CCT/TriC
    Mitotic Prometaphase
    Translocation of GLUT4 to the plasma membrane
    Recruitment of NuMA to mitotic centrosomes
    Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
    Formation of tubulin folding intermediates by CCT/TriC
    Recycling pathway of L1
    Gap junction assembly
    Post-chaperonin tubulin folding pathway
    Separation of Sister Chromatids
    MHC class II antigen presentation
    Kinesins


    3 Kegg Pathways  (Kegg details for TUBA1C):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Array including TUBA1C: 
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TUBA1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBA1C (Q9BQE32, 3 ENSP000003010724) via UniProtKB, MINT, STRING, and/or I2D (see all 740)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAQP273482, 3, ENSP000002380814MINT-7900157 I2D: score=1 STRING: ENSP00000238081
    NSFP464592, 3MINT-7947479 I2D: score=1 
    UBA5Q9GZZ92, 3MINT-7947479 I2D: score=1 
    TJP1Q071572, 3, ENSP000002815374MINT-2984901 I2D: score=3 STRING: ENSP00000281537
    CDKN2AP427713, ENSP000003551534I2D: score=1 I2D: score=1 STRING: ENSP00000355153
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization ----
    GO:0006184GTP catabolic process ----
    GO:0006457protein folding TAS--
    GO:0007017microtubule-based process TAS12090300
    GO:0030705cytoskeleton-dependent intracellular transport TAS12090300

    Find genes that share ontologies with TUBA1C           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for TUBA1C available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 HMDB Compound for TUBA1C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 DrugBank Compounds for TUBA1C    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Epothilone BEPO 906 (see all 3)152044-54-7target--17139284 17016423
    Epothilone D-- 189453-10-9target--17139284 17016423
    2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TUBA1C gene: 
    NM_032704.3  

    Unigene Cluster for TUBA1C:

    Tubulin, alpha 1c
    Hs.652390  [show with all ESTs]
    Unigene Representative Sequence: AK293589
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549554 ENST00000550574 ENST00000541364(uc010smh.1) ENST00000549818
    ENST00000552448 ENST00000552125 ENST00000301072(uc001rtt.1) ENST00000549183
    ENST00000548470
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TUBA1C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TUBA1C
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TUBA1C
    Predesigned siRNA for gene silencing in human, mouse, rat TUBA1C
    Clone
    Products:
         
    OriGene clones in human, mouse for TUBA1C (see all 7)
    OriGene ORF clones in mouse, rat for TUBA1C
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TUBA1C
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBA1C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBA1C
      QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
      QuantiFast Probe-based Assays in human, mouse, rat TUBA1C

    Additional mRNA sequence: 

    AK223024.1 AK293589.1 BC004949.1 BC005946.1 BC011790.1 BC019298.2 BC021088.1 BC033064.1 
    BC051297.1 BC063036.1 D28390.1 

    Selected DOTS entries (see all 170):

    DT.95214022  DT.100744545  DT.99926617  DT.100744301  DT.100842020  DT.100744421  DT.121136664  DT.95320022 
    DT.92475285  DT.100744242  DT.100744456  DT.97869896  DT.92475277  DT.121136256  DT.95174359  DT.121136350 
    DT.121134955  DT.100856215  DT.92475321  DT.92475326  DT.98083143  DT.100744540  DT.121134834  DT.97869904 

    19 AceView cDNA sequences:

    BC021088 CR610386 CR595837 CR599151 CR599275 BC011790 D28390 CR599812 
    CR624182 CR603141 BC019298 BC051297 CR613152 CR605574 BC063036 BC004949 
    BC005946 NM_032704 BC033064 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TUBA1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGCCCTTG
    TUBA1C Expression
    About this image


    TUBA1C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    TUBA1C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBA1C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.652390
        Pathway & Disease-focused RT2 Profiler PCR Array including TUBA1C: 
              Gap Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TUBA1C
    OriGene qSTAR qPCR primer pairs in human, mouse for TUBA1C
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBA1C
    QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
    QuantiFast Probe-based Assays in human, mouse, rat TUBA1C
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBA1C gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tuba1c1 , 5 tubulin, alpha 1C1, 5 93.76(n)1
    99.33(a)1
      15 (55.61 cM)5
    221461  NM_009448.41  NP_033474.11 
     990298915 
    chicken
    (Gallus gallus)
    Aves LOC1008572471 tubulin alpha-5 chain-like 84.3(n)
    95.98(a)
      100857247  XM_004942841.1  XP_004942898.1 
    lizard
    (Anolis carolinensis)
    Reptilia TUBA1C6
    tubulin, alpha 1c
    99(a)
    1 ↔ 1
    GL343198.1(2510602-2522950)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC046841.12   -- 86.81(n)    BC046841.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tuba1b1 tubulin, alpha 1b 85.23(n)
    98(a)
      373080  NM_194388.2  NP_919369.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta alphaTub84B1 alpha-Tubulin at 84B 82.33(n)
    96.88(a)
      40848  NM_057424.4  NP_476772.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tba-21 tba-2 75.76(n)
    88.37(a)
      173167  NM_001025879.3  NP_001021050.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TUB11 TUB1 64.87(n)
    74.83(a)
      854889   NP_013625.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TUA21 TUA2 75.28(n)
    85.75(a)
      841425  NM_103889.3  NP_175423.1 
    rice
    (Oryza sativa)
    Liliopsida Os.95042 O.sativa mRNA for alpha-tubulin (clone OSTA-274) 79.93(n)    AK069140.1 


    ENSEMBL Gene Tree for TUBA1C (if available)
    TreeFam Gene Tree for TUBA1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TUBA1C gene
    TUBA3C2  TUBA4A2  TUBA1B2  TUBA1A2  TUBA3E2  TUBA82  TUBA3D2  
    Selected SIMAP similar genes for TUBA1C using alignment to 6 protein entries:     TBA1C_HUMAN (see all proteins) (see all similar genes):
    TUBA1    TUBA4B    TUBA1A    TUBA4A    FP1523    ZNF114
    TUBA1B    NDUFS3    PUS1    TUBA2    TUBA3C    TUBA3D
    TUBA3E    NLN    PACRG    SH2B3    TM4SF19    TUBA8

    Find genes that share paralogs with TUBA1C           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for TUBA1C
    PGOHUM00000244008 PGOHUM00000261295 PGOHUM00000244705


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TUBA1C (see all 168)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1907773521,2
    C--49493631(+) AGATCG/TCACCA 1 -- int10--------
    rs23354521,2
    C,F,A,H--49493648(-) GTCTCG/CCTGGA 1 -- int16Minor allele frequency- C:0.03NS EA NA 632
    rs1397223061,2
    --49493673(+) ACGTAC/TATGAA 1 -- int10--------
    rs1831612351,2
    --49493676(+) TACATG/TAATTT 1 -- int10--------
    rs733062631,2
    C,F--49493707(+) AATACA/TTGTAT 1 -- int13Minor allele frequency- T:0.06WA CSA 122
    rs111689481,2
    C,F,A,H--49493751(+) AAGCAG/ATACCA 1 -- int120Minor allele frequency- A:0.19NS EA NA WA CSA 2338
    rs123100931,2
    C,F--49494033(+) AATTGC/GGGGCG 1 -- int11Minor allele frequency- G:0.06WA 118
    rs1443831061,2
    --49494160(+) GCTTTC/TTGGGG 1 -- int10--------
    rs1461111731,2
    C--49494238(+) CCCAGC/TACTTT 1 -- int10--------
    rs1880015591,2
    --49494252(+) AGGCCA/GAGGTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TUBA1C (49582519 - 49667114 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TUBA1C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv507642CNV Insertion20534489
    nsv509466CNV Insertion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBA1C
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBA1C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    2 diseases for TUBA1C:    
    About MalaCards
    distal hereditary motor neuropathy, type ii    osteoblastoma

    1 disease from the University of Copenhagen DISEASES database for TUBA1C:
    Osteoblastoma

    Find genes that share disorders with TUBA1C           About GenesLikeMe

    Genetic Association Database (GAD): TUBA1C

    Export disorders for TUBA1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TUBA1C gene, integrated from 10 sources (see all 86):
    (articles sorted by number of sources associating them with TUBA1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Construction of a human full-length cDNA bank. (PubMed id 7821789)1, 3 Kato S....Aoki T. (Gene 1994)
    4. The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)1 Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
    5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    6. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (PubMed id 23703321)1 New M....La Thangue N.B. (Cell Death Differ. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)1 Haines D.S....Deshaies R.J. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84790 HGNC: 20768 AceView: TUBA6 Ensembl:ENSG00000167553 euGenes: HUgn84790
    ECgene: TUBA1C Kegg: 84790 H-InvDB: TUBA1C

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TUBA1C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TUBA1C gene:
    Search GeneIP for patents involving TUBA1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TUBA1C   OriGene RNAi products in human, mouse, rat for TUBA1C  
     OriGene qPCR primer pairs and template standards for TUBA1C   OriGene Protein Over-expression Lysate for TUBA1C  
     OriGene MassSpec for TUBA1C   OriGene clones in human, mouse for TUBA1C  
     OriGene qSTAR qPCR primer pairs in human, mouse for TUBA1C   OriGene Purified Protein for TUBA1C  
     OriGene ORF clones in mouse, rat for TUBA1C   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TUBA1C   OriGene Custom Protein Services for TUBA1C  

     
     
     Block miRNA regulation of human, mouse, rat TUBA1C using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TUBA1C
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBA1C Predesigned siRNA for gene silencing in human, mouse, rat TUBA1C
     QuantiFast Probe-based Assays in human, mouse, rat TUBA1C QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
     PCR Arrays including human, mouse, rat TUBA1C Search Chromatin IP Primers for TUBA1C
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TUBA1C  Search GeneGlobe Interaction Network for TUBA1C
     Regulatory tfbs in TUBA1C promoter
     GenScript Custom Purified and Recombinant Proteins Services for TUBA1C GenScript cDNA clones with any tag delivered in your preferred vector for TUBA1C
     GenScript Custom Assay Services for TUBA1C GenScript Custom overexpressing Cell Line Services for TUBA1C
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for TUBA1C
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for TUBA1C
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TUBA1C antibodies
     TUBA1C proteins
     TUBA1C lysates
     Antibodies for TUBA1C
     See all of Abcam's Antibodies, Kits and Proteins for TUBA1C
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for TUBA1C
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TUBA1C
     SwitchGear Promoter luciferase reporter plasmids for TUBA1C
     ThermoFisher Antibody for TUBA1C
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBA1C
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TUBA1C
     LSBio Antibodies in human, mouse, rat for TUBA1C
     Browse compounds at ApexBio
     Search Addgene for plasmids for TUBA1C
      Search eBioscience for proteins for TUBA1C
      Search eBioscience for elisas for TUBA1C
      eBioscience FlowRNA Probe Sets
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     antibodies-online antibodies for TUBA1C (49 products)
     antibodies-online kits for TUBA1C (8 products)
     antibodies-online peptides for TUBA1C
     antibodies-online proteins for TUBA1C (6 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TUBA1C gene at Home site.
    Version: 3.12.234 23 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4