Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TUBA1C Gene

Aliases for TUBA1C Gene

  • Tubulin, Alpha 1c 2 3
  • Tubulin Alpha-6 Chain 3 4
  • Tubulin, Alpha 6 2 3
  • Alpha-Tubulin 6 3 4
  • TUBA6 3 4
  • Tubulin Alpha-1C Chain 3
  • Bcm948 3

External Ids for TUBA1C Gene

Previous Symbols for TUBA1C Gene

  • TUBA6

Summaries for TUBA1C Gene

GeneCards Summary for TUBA1C Gene

TUBA1C (Tubulin, Alpha 1c) is a Protein Coding gene. Diseases associated with TUBA1C include osteoblastoma and distal hereditary motor neuropathy, type ii. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and EphB-EphrinB Signaling. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot for TUBA1C Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Tocris Summary for TUBA1C Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1C Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA1C Gene

Genomics for TUBA1C Gene

Genomic Location for TUBA1C Gene

Start:
49,188,736 bp from pter
End:
49,274,603 bp from pter
Size:
85,868 bases
Orientation:
Plus strand

Genomic View for TUBA1C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBA1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA1C Gene

Regulatory Elements for TUBA1C Gene

Proteins for TUBA1C Gene

  • Protein details for TUBA1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQE3-TBA1C_HUMAN
    Recommended name:
    Tubulin alpha-1C chain
    Protein Accession:
    Q9BQE3
    Secondary Accessions:

    Protein attributes for TUBA1C Gene

    Size:
    449 amino acids
    Molecular mass:
    49895 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells

neXtProt entry for TUBA1C Gene

Proteomics data for TUBA1C Gene at MOPED

Post-translational modifications for TUBA1C Gene

  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys60, Lys96, Lys112, Lys163, Lys280, Lys304, Lys311, Lys326, Lys336, Lys338, Lys352, Lys370, Lys394, and Lys401

Other Protein References for TUBA1C Gene

No data available for DME Specific Peptides for TUBA1C Gene

Domains for TUBA1C Gene

Gene Families for TUBA1C Gene

HGNC:
  • TUB :Tubulins

Suggested Antigen Peptide Sequences for TUBA1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQE3

UniProtKB/Swiss-Prot:

TBA1C_HUMAN
Family:
  • Belongs to the tubulin family.:
    • Q9BQE3
genes like me logo Genes that share domains with TUBA1C: view

Function for TUBA1C Gene

Molecular function for TUBA1C Gene

UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Gene Ontology (GO) - Molecular Function for TUBA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 12090300
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 22720776
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBA1C: view
genes like me logo Genes that share phenotypes with TUBA1C: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBA1C Gene

Localization for TUBA1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA1C Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBA1C Gene COMPARTMENTS Subcellular localization image for TUBA1C gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
GO:0005874 microtubule TAS 12090300
GO:0005881 cytoplasmic microtubule IEA --
GO:0031982 vesicle IDA 19190083
genes like me logo Genes that share ontologies with TUBA1C: view

Pathways for TUBA1C Gene

genes like me logo Genes that share pathways with TUBA1C: view

Gene Ontology (GO) - Biological Process for TUBA1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006457 protein folding TAS --
GO:0007017 microtubule-based process TAS 12090300
GO:0030705 cytoskeleton-dependent intracellular transport TAS 12090300
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TUBA1C: view

Compounds for TUBA1C Gene

(5) Tocris Compounds for TUBA1C Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Epothilone B Microtubule stabilization agent; promotes tubulin polymerization [152044-54-7]
Vinblastine sulfate Disrupts microtubules [143-67-9]
Vinorelbine ditartrate Selective mitotic microtubule antagonist [125317-39-7]

(1) HMDB Compounds for TUBA1C Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(3) Drugbank Compounds for TUBA1C Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
target
Epothilone B
  • EPO 906
152044-54-7 target
Epothilone D
189453-10-9 target
genes like me logo Genes that share compounds with TUBA1C: view

Transcripts for TUBA1C Gene

Unigene Clusters for TUBA1C Gene

Tubulin, alpha 1c:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA1C Gene

No ASD Table

Relevant External Links for TUBA1C Gene

GeneLoc Exon Structure for
TUBA1C
ECgene alternative splicing isoforms for
TUBA1C

Expression for TUBA1C Gene

mRNA expression in normal human tissues for TUBA1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TUBA1C Gene

This gene is overexpressed in Esophagus - Mucosa (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBA1C Gene

SOURCE GeneReport for Unigene cluster for TUBA1C Gene Hs.652390

genes like me logo Genes that share expressions with TUBA1C: view

No data available for mRNA Expression by UniProt/SwissProt for TUBA1C Gene

Orthologs for TUBA1C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBA1C 35
  • 99.4 (n)
  • 100 (a)
TUBA1C 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 98 (a)
ManyToMany
TUBA1C 35
  • 94.88 (n)
  • 98.44 (a)
dog
(Canis familiaris)
Mammalia TUBA1C 35
  • 95.1 (n)
  • 99.33 (a)
TUBA1C 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tuba1c 35
  • 93.76 (n)
  • 99.33 (a)
Tuba1c 16
Tuba1c 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia LOC100909441 35
  • 93.76 (n)
  • 99.11 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 56 (a)
OneToMany
LOC100857247 35
  • 84.3 (n)
  • 95.98 (a)
lizard
(Anolis carolinensis)
Reptilia TUBA1C 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75684 35
tuba1c 35
  • 86.56 (n)
  • 98.89 (a)
zebrafish
(Danio rerio)
Actinopterygii tuba1b 35
  • 85.23 (n)
  • 98 (a)
tuba1b 36
  • 98 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010971 35
  • 79.99 (n)
  • 96.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta alphaTub84B 35
  • 82.33 (n)
  • 96.88 (a)
CG7794 36
  • 52 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tba-2 35
  • 75.76 (n)
  • 88.37 (a)
Y19D2B.1 36
  • 80 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR441C 35
  • 66.89 (n)
  • 74.61 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB1 35
  • 64.87 (n)
  • 74.83 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16874g 35
  • 64.71 (n)
  • 74.77 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons TUA2 35
  • 75.28 (n)
  • 85.75 (a)
rice
(Oryza sativa)
Liliopsida Os.9504 35
Os11g0247300 35
  • 76.91 (n)
  • 84.41 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.812 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09468 35
  • 72.75 (n)
  • 78.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes nda2 35
  • 67.19 (n)
  • 77.23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
Species with no ortholog for TUBA1C:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TUBA1C Gene

ENSEMBL:
Gene Tree for TUBA1C (if available)
TreeFam:
Gene Tree for TUBA1C (if available)

Paralogs for TUBA1C Gene

Paralogs for TUBA1C Gene

Pseudogenes.org Pseudogenes for TUBA1C Gene

genes like me logo Genes that share paralogs with TUBA1C: view

Variants for TUBA1C Gene

Sequence variations from dbSNP and Humsavar for TUBA1C Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1057748 -- 49,272,399(+) CCGGC(A/G)CCCCA synonymous-codon, reference
rs2335451 -- 49,271,003(-) TTAGG(G/T)ttttt intron-variant
rs2335452 -- 49,266,821(-) GTCTC(C/G)CTGGA intron-variant
rs2335453 -- 49,266,588(-) tacaa(A/C)cataa intron-variant
rs3759170 -- 49,267,514(-) GCCTG(C/G)CTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TUBA1C Gene

Variant ID Type Subtype PubMed ID
nsv507642 CNV Insertion 20534489
nsv509466 CNV Insertion 20534489

Relevant External Links for TUBA1C Gene

HapMap Linkage Disequilibrium report
TUBA1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBA1C Gene

Disorders for TUBA1C Gene

(1) University of Copenhagen DISEASES for TUBA1C Gene

Relevant External Links for TUBA1C

Genetic Association Database (GAD)
TUBA1C
genes like me logo Genes that share disorders with TUBA1C: view

No data available for UniProtKB/Swiss-Prot for TUBA1C Gene

Publications for TUBA1C Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  2. Construction of a human full-length cDNA bank. (PMID: 7821789) Kato S. … Aoki T. (Gene 1994) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A universal strategy for proteomic studies of SUMO and other ubiquitin-like modifiers. (PMID: 15576338) Rosas-Acosta G. … Wilson V.G. (Mol. Cell Proteomics 2005) 3
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3

Products for TUBA1C Gene

Sources for TUBA1C Gene

Back to Top

Content