TUBA1C Gene
protein-coding GIFtS : 56
GCID: GC12 P049658
tubulin, alpha 1c (Previous names: tubulin, alpha 6 ) (Previous symbol: TUBA6 )
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Aliasesfor TUBA1C gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Tubulin, Alpha 1c 1 2 Tubulin Alpha-6 Chain2 3 TUBA61 2 3 MGC108511 Bcm9481 MGC145801 Tubulin, Alpha 61 2 Tubulin Alpha-1C Chain2 Alpha-Tubulin 62 3
Export aliases for TUBA1C gene to outside databases Previous GC identifers: GC12P047908 GC12P046689
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Summariesfor TUBA1C gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 Function : Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site onthe beta chain and one at a non-exchangeable site on the alpha chain summary
for TUBA1C : Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are inturn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunitsare exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determinecell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requiresmotor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) endof the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form thespindle fibers for separating chromosomes during mitosis. Gene Wiki entry for TUBA1C
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Viewsfor TUBA1C gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TUBA1C gene promoter: HNF-1A YY1 PPAR-gamma1 CBF-A CBF-B HNF-1 PPAR-gamma2 CBF(2) Other transcription factors Search SABiosciences Chromatin IP Primers for TUBA1C Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TUBA1C
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12 TUBA1C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P049658: view genomic region
(about GC identifiers )
Start:
49,582,519 bp from pter
End:
49,667,114 bp from pter
Size:
84,596 bases
Orientation:
plus strand
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Proteinsfor TUBA1C gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 (See
protein sequence )Recommended Name: Tubulin alpha-1C chain Size : 449 amino acids; 49895 Da
Subunit : Dimer of alpha and beta chains
Subcellular location : Cytoplasm, cytoskeletonExplore the universe of human proteins at neXtProt for TUBA1C: NX_Q9BQE3 Post-translational modifications:
Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity)1
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BQE3 TUBA1C Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_116093.1 ENSEMBL proteins: ENSP00000443475 ENSP00000447669 ENSP00000448646 ENSP00000447910 ENSP00000301072 ENSP00000448211 Reactome Protein details: Q9BQE3 Human Recombinant Protein Products: Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view) : About this table
TUBA1C for ontologies About GeneDecksing TUBA1C Antibody Products: Assay Products for TUBA1C:
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Protein
Domains / Familiesfor TUBA1C gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TUBA1C for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q9BQE3 ProtoNet protein and cluster: Q9BQE3
1 Blocks protein family : IPB002452 Alpha tubulin signature UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 Similarity : Belongs to the tubulin family
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Functionfor TUBA1C gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 Function : Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site onthe beta chain and one at a non-exchangeable site on the alpha chain
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TUBA1C (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TUBA1C (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TUBA1C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TUBA1C
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view) : About this table
TUBA1C for ontologies About GeneDecksing 6 GenomeRNAi human phenotypes for TUBA1C :
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Pathways & Interactionsfor TUBA1C gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/28 super-pathways (see all 28 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 M Phase 2 Recruitment of mitotic centrosome proteins and complexes 3 Axon guidance 4 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 5 Formation of tubulin folding intermediates by CCT/TriC
Pathway sources See GeneCards unified pathways Show all pathways 5/9 EMD Millipore Pathways for TUBA1C (see all 9 )5/10 GeneGo (Thomson Reuters) Pathways for TUBA1C (see all 10 )2 BioSystems Pathways for TUBA1C 5/41
Reactome Pathways for TUBA1C (see all 41 )3
Kegg Pathways (Kegg details for TUBA1C) :
TUBA1C for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TUBA1C STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/672 Interacting proteins for TUBA1C (Q9BQE3 2 , 3 ENSP00000301072 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 672 )About this table Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9 ): About this table
TUBA1C for ontologies About GeneDecksing
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Drugs & Compoundsfor TUBA1C gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Compounds for TUBA1C available from Tocris Bioscience About this table 1 HMDB Compound for TUBA1C About this table 3 DrugBank Compounds for TUBA1C About this table Search CenterWatch for drugs/clinical trials and news about TUBA1C / TBA1C
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Transcriptsfor TUBA1C gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TUBA1C gene: NM_032704.3 Unigene Cluster for TUBA1C:
Tubulin, alpha 1c Hs.652390 [show with all ESTs ] Unigene Representative Sequence: AK293589 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000549554 ENST00000550574 ENST00000541364 (uc010smh.1 ) ENST00000549818 ENST00000552448 ENST00000552125 ENST00000301072 (uc001rtt.1 ) ENST00000549183 ENST00000548470 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TUBA1C (see all 5 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TUBA1C (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TUBA1C Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TUBA1C
Additional cDNA sequence: AK223024.1 AK293589.1 BC004949.1 BC005946.1 BC011790.1 BC019298.2 BC021088.1 BC033064.1 BC051297.1 BC063036.1 D28390.1
24/169 DOTS entries (see all 169 ): DT.95214022 DT.100744545
DT.99926617 DT.100744301 DT.100842020 DT.100744421 DT.121136664 DT.92475285 DT.95320022 DT.100744242 DT.100744456 DT.97869896 DT.92475277 DT.121136256 DT.95174359 DT.121134955 DT.121136350 DT.100856215 DT.92475321 DT.92475326 DT.98083143 DT.100744540 DT.121134834 DT.97869904 19 AceView cDNA sequences :
CR610386 CR624182 CR599275 CR595837 CR599151 CR605574 BC051297 BC019298 BC021088 D28390 CR599812 CR603141 BC011790 CR613152 BC063036 BC005946 NM_032704 BC004949 BC033064 GeneLoc Exon Structure
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Expression for TUBA1C gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TUBA1C expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCTGCCCTTG
About this image TUBA1C expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Endoderm-like cells (Generation of hepato... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TUBA1C Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TUBA1C SOURCE GeneReport for Unigene cluster: Hs.652390 SABiosciences Expression via Pathway-Focused PCR Array including TUBA1C : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TUBA1CBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TUBA1C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TUBA1C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TUBA1C
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Orthologsfor TUBA1C gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for TUBA1C gene from 8/24 species (see all 24 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
lizard (Anolis carolinensis)
Reptilia
TUBA1C6
--
99(a)
1 ↔ 1
GL343198.1(2510602-2513168)
African clawed frog (Xenopus laevis)
Amphibia
BC046841.12
--
86.81(n)
 
BC046841.1
zebrafish (Danio rerio)
Actinopterygii
tuba11
tubulin, alpha 1
85.23(n) 98(a)
 
373080 NM_194388.2 NP_919369.2
fruit fly (Drosophila melanogaster)
Insecta
alphaTub85E1
alpha-Tubulin at 85E
80.25(n) 94.65(a)
 
41183 NM_079573.4 NP_524297.1
worm (Caenorhabditis elegans)
Secernentea
tba-91
Protein TBA-9
71.23(n) 85.65(a)
 
185538 NM_076154.2 NP_508555.2
baker's yeast (Saccharomyces cerevisiae)
Saccharomycetes
TUB11
Tub1p
64.87(n) 74.83(a)
 
854889 NP_013625.1
thale cress (Arabidopsis thaliana)
eudicotyledons
TUA21
tubulin alpha-2/alpha-4 chain
75.28(n) 85.75(a)
 
841425 NM_103889.3 NP_175423.1
rice (Oryza sativa)
Liliopsida
Os.95042
O.sativa mRNA for alpha-tubulin (clone OSTA-274)
79.93(n)
 
AK069140.1
ENSEMBL Gene Tree for TUBA1C (if available)TreeFam Gene Tree for TUBA1C (if available)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Paralogsfor TUBA1C gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TUBA1C gene TUBA3C 2 TUBA4A 2 TUBA1B 2 TUBA1A 2 TUBAL3 2 TUBA3E 2 TUBA3D 2 TUBA8 2 18/179 SIMAP similar genes for TUBA1C using alignment to 6 protein entries: TBA1C_HUMAN (see all proteins )
(see all similar genes ):TUBA1 TUBA4B TUBA4A FP1523 TUBA1B TUBA1A NDUFS3 PUS1 TUBA2 TUBA3C TUBA3D TUBA3E NLN PACRG SH2B3 TM4SF19 TUBA8 CALCOCO2
TUBA1C for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for TUBA1C PGOHUM00000244008 PGOHUM00000261295 PGOHUM00000244705
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genomic Variantsfor TUBA1C gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TUBA1C (49582519 - 49667114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TUBA1C: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TUBA1C
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Disorders
/ Diseasesfor TUBA1C gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TUBA1C for disorders About GeneDecksing 11 diseases for TUBA1C : About MalaCards distal hereditary motor neuropathy distal hereditary motor neuropathy, type ii chondroblastoma neuropathy endocarditis parkinson's disease gastric cancer myeloma immunodeficiency malaria neuronitis 1 disease from the University of Copenhagen DISEASES database for TUBA1C :Osteoblastoma Export disorders for TUBA1C gene to outside databases
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Publicationsfor TUBA1C gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TUBA1C gene, integrated from 9 sources (see all 69 ) (see top 10 ): (articles sorted by number of sources associating them with TUBA1C) Utopia : connect your pdf to the dynamic world of online information
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 1 , 2 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Construction of a human full-length cDNA bank. (PubMed id 7821789) 1 , 3 Kato S....Aoki T. (1994) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587) 1 Haines D.S....Deshaies R.J. (2012) A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883) 1 Kristensen A.R....Foster L.J. (2012) The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925) 1 Aichem A....Groettrup M. (2012) Characterization of the protein ubiquitination respons e induced by Doxorubicin. (PubMed id 22536838) 1 Mandili G....Turrini F. (2012) Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317) 1 Naji S....Gerace L. (2012) Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724) 1 Udeshi N.D....Carr S.A. (2012) Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326) 1 Tsai Y.C....Cristea I.M. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266) 1 Shi Y....Qin J. (2011) Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590) 1 Emanuele M.J....Elledge S.J. (2011) Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983) 1 Kim W....Gygi S.P. (2011) Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943) 1 Bruderer R....Hay R.T. (2011) Huwe1, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity. (PubMed id 21167302) 1 Yamamoto S.P....Suzuki Y. (2011) An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273) 1 Neganova I....Lako M. (2011) Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572) 1 Lee K.A....Doedens J.R. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) Up-regulation of 42 kDa tubulin alpha-6 chain fragment in well-differentiated hepatocellular carcinoma tissues from patients infected with hepatitis C virus. (PubMed id 21965743) 1 Kuramitsu Y....Nakamura K. (2011) Identification of ubiquitinated proteins from human m ultiple myeloma U266 cells by proteomics. (PubMed id 22108332) 1 Jia H....He Q. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692) 2 Rigbolt K.T....Blagoev B. (2011) Identification of FBXO25-interacting proteins using an integrated proteomics approach. (PubMed id 20473970) 1 Teixeira F.R.... Gomes M.D. (2010) Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PubMed id 20618440) 1 Pozuelo-Rubio M. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231) 2 Olsen J.V....Mann M. (2010) Proteomics analysis of nucleolar SUMO-1 target protei ns upon proteasome inhibition. (PubMed id 19596686) 1 Matafora V....Bachi A. (2009) Charting the molecular network of the drug target Bcr-Abl. (PubMed id 19380743) 1 Brehme M....Superti-Furga G. (2009) Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. (PubMed id 19524510) 2 Rogowski K....Janke C. (2009) Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. (PubMed id 19287380) 1 Maddika S. and Chen J. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332) 2 Mayya V.... Han D.K. (2009) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 2 Daub H.... Mann M. (2008) The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. (PubMed id 18214993) 1 Gandhi P.N....Wilson-Delfosse A.L. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 2 Dephoure N.... Gygi S.P. (2008) Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797) 1 Meierhofer D.... Kaiser P. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 1 Barbe L....Andersson-Svahn H. (2008) Susceptibility to virus-cell fusion at the plasma membrane is reduced through expression of HIV gp41 cytoplasmic domains. (PubMed id 18400243) 1 Malinowsky K....Dittmar M.T. (2008) Modulation of microtubule assembly by the HIV-1 Tat protein is strongly dependent on zinc binding to Tat. (PubMed id 18613978) 1 Egele C....Mely Y. (2008) Proteomic analysis of p16ink4a-binding proteins. (PubMed id 17955473) 1 Souza-Rodrigues E....Jaumot M. (2007) Functional specialization of beta-arrestin interactions revealed by proteomic analysis. (PubMed id 17620599) 1 Xiao K....Lefkowitz R.J. (2007) Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. (PubMed id 17360745) 1 Jolly C....Sattentau Q.J. (2007) HDM2-binding partners: interaction with translation elongation factor EF1alpha. (PubMed id 17373842) 1 Frum R....Deb S.P. (2007) Inhibitory effect of HIV-1 Tat protein on the sodium-D-glucose symporter of human intestinal epithelial cells. (PubMed id 16327313) 1 Canani R.B....Guarino A. (2006) How many drug targets are there? (PubMed id 17139284) 7 Overington J.P....Hopkins A.L. (2006)
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
External Searches for TUBA1C gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Genome Databases showing TUBA1C gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Other Databases showing TUBA1C gene
(According to HUGE )
About This Section --
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Specialized Databases showing TUBA1C gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TUBA1C Pharmacogenomics, SNPs, Pathways
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
About This Section Patent Information for TUBA1C gene: Search GeneIP for patents involving TUBA1C GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
Jump to Section...
Aliases
Databases
Disorders / Diseases
Domains / Families
Drugs / Compounds
Expression
Function
Genomic Views
Intellectual Property
Orthologs
Paralogs
Pathways / Interactions
Products
Proteins
Publications
Search Box
Summaries
Transcripts
Variants
TOP
BOTTOM
Productsfor TUBA1C gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TUBA1C OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TUBA1C OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TUBA1C OriGene Protein Over-expression Lysate for TUBA1C Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TUBA1C OriGene 3'-UTR Clone for TUBA1C OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TUBA1C OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TUBA1C Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TUBA1C OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TUBA1C OriGene Custom Protein Services for TUBA1C OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUBA1C QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TUBA1C QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat TUBA1C QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TUBA1C QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TUBA1C QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TUBA1C
Search ThermoFisher Antibodies for TUBA1C
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TUBA1C
Jump to Section...
Aliases for TUBA1C
Databases for TUBA1C
Disorders / Diseases for TUBA1C
Domains / Families for TUBA1C
Drugs / Compounds for TUBA1C
Expression for TUBA1C
Function for TUBA1C
Genomic Views for TUBA1C
Intellectual Property for TUBA1C
Orthologs for TUBA1C
Paralogs for TUBA1C
Pathways / Interactions for TUBA1C
Products for TUBA1C
Proteins for TUBA1C
Publications for TUBA1C
Search Box for TUBA1C
Summaries for TUBA1C
Transcripts for TUBA1C
Variants for TUBA1C
TOP
BOTTOM