Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUBA1C Gene

protein-coding GIFtS: 56
GCID: GC12P049658

tubulin, alpha 1c

(Previous names: tubulin, alpha 6 )
(Previous symbol: TUBA6)

Explore 11 diseases affiliated with
TUBA1C via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Tubulin, Alpha 1c¹ ²		Tubulin Alpha-6 Chain² ³
TUBA6¹ ² ³		MGC10851¹
Bcm948¹		MGC14580¹
Tubulin, Alpha 6¹ ²		Tubulin Alpha-1C Chain²
Alpha-Tubulin 6² ³

External Ids:	HGNC: 20768¹	Entrez Gene: 84790²	Ensembl: ENSG00000167553⁷	UniProtKB: Q9BQE3³

Export aliases for TUBA1C gene to outside databases

Previous GC identifers: GC12P047908 GC12P046689

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA1C:

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in

turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits

are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine

cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires

motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end

of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the

spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TUBA1C gene promoter:
HNF-1A YY1 PPAR-gamma1 CBF-A CBF-B HNF-1 PPAR-gamma2 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUBA1C promoter sequence

Search SABiosciences Chromatin IP Primers for TUBA1C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA1C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12

TUBA1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA1C gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P049658: view genomic region (about GC identifiers)

Start:	49,582,519 bp from pter	End:	49,667,114 bp from pter
Size:	84,596 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 (See protein sequence)

Recommended Name: Tubulin alpha-1C chain

Size: 449 amino acids; 49895 Da

Subunit: Dimer of alpha and beta chains

Subcellular location: Cytoplasm, cytoskeleton

Explore the universe of human proteins at neXtProt for TUBA1C: NX_Q9BQE3

Post-translational modifications:

Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by

the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity)¹

Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate

residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated

due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into

axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the

mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation

levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but

they regulate the assembly and dynamics of axonemal microtubules (Probable)¹

Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule

motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle

progression or cell differentiation to intracellular trafficking and signaling (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BQE3

TUBA1C Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_116093.1

ENSEMBL proteins:

ENSP00000443475 ENSP00000447669 ENSP00000448646 ENSP00000447910 ENSP00000301072

ENSP00000448211

Reactome Protein details: Q9BQE3
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: TUBA1C OriGene Protein Over-expression Lysate: TUBA1C OriGene Custom Protein Services for TUBA1C
	GenScript Custom Purified and Recombinant Proteins Services for TUBA1C
	Novus Biologicals TUBA1C Protein Novus Biologicals TUBA1C Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005874	microtubule	TAS	12090300
GO:0005881	cytoplasmic microtubule	IEA	--
GO:0015630	microtubule cytoskeleton	IDA	--

TUBA1C for ontologies About GeneDecksing

TUBA1C Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for TUBA1C
	GenScript Custom Superior Antibodies Services for TUBA1C
	Novus Biologicals TUBA1C Antibodies
	Search for Antibodies for TUBA1C at Abcam
	Browse Antibodies at Uscn
	Search ThermoFisher Antibodies for TUBA1C

Assay Products for TUBA1C:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TUBA1C
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TUBA1C for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR002452 Alpha_tubulin

IPR000217 Tubulin

IPR003008 Tubulin_FtsZ_GTPase

IPR023123 Tubulin_C

IPR008280 Tub_FtsZ_C

Graphical View of Domain Structure for InterPro Entry Q9BQE3

ProtoNet protein and cluster: Q9BQE3

1 Blocks protein family: IPB002452 Alpha tubulin signature

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3

Similarity: Belongs to the tubulin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

miRNA Products:		OriGene 3'-UTR Clone: TUBA1C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBA1C
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TUBA1C
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBA1C (see all 4) OriGene shRNA RFP: TUBA1C OriGene siRNA: TUBA1C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA1C

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TUBA1C

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1C (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1C (see first 1) BC033064 (human cat#: SC104905) NM_032704 (human cat#: SC319711) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TUBA1C
		Search LifeMap BioReagents cell lines for TUBA1C

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA1C

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005198	structural molecule activity	TAS	12090300
GO:0005200	structural constituent of cytoskeleton	--	--
GO:0005525	GTP binding	IEA	--
GO:0019904	protein domain specific binding	--	--

TUBA1C for ontologies About GeneDecksing

6 GenomeRNAi human phenotypes for TUBA1C:

Cell division defect	Decreased Hepatitis C virus re	Decreased cell number, increas	Decreased viability of wild-ty
Increased gamma-H2AX phosphory	Increased number of mitotic ce

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/28 super-pathways (see all 28) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

Recruitment of mitotic centrosome proteins and complexes

	Recruitment of mitotic centrosome proteins and complexes	1.00			G2/M Transition	0.83
	Centrosome maturation	1.00			Mitotic G2-G2/M phases	0.81

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69			Recycling pathway of L1	0.15

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	1.00			Post-chaperonin tubulin folding pathway	0.67
	Transport of connexons to the plasma membrane	0.93			Recruitment of NuMA to mitotic centrosomes	0.50

Formation of tubulin folding intermediates by CCT/TriC

	Formation of tubulin folding intermediates by CCT/TriC	1.00			Prefoldin mediated transfer of substrate to CCT/TriC	0.70
	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	0.74

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for TUBA1C (see all 9)

	Cytoskeleton remodeling Neurofilaments
	Cytoskeleton remodeling Slit-Robo signaling
	Cytoplasmic microtubules
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cytoskeleton remodeling Keratin filaments

5/10 GeneGo (Thomson Reuters) Pathways for TUBA1C (see all 10)

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Cell cycle Spindle assembly and chromosome separation
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Keratin filaments

2 BioSystems Pathways for TUBA1C

	Parkin-Ubiquitin Proteasomal System pathway
	Pathogenic Escherichia coli infection

5/41 Reactome Pathways for TUBA1C (see all 41)

	L1CAM interactions
	Mitotic Prometaphase
	Membrane Trafficking
	Protein folding
	Recruitment of mitotic centrosome proteins and complexes

3 Kegg Pathways (Kegg details for TUBA1C):

	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection

TUBA1C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TUBA1C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/672 Interacting proteins for TUBA1C (Q9BQE3^{2, 3} ENSP00000301072⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 672)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAQ	P27348²^,³, ENSP00000238081⁴	MINT-7900157 I2D: score=1 STRING: ENSP00000238081
NSF	P46459²^,³	MINT-7947479 I2D: score=1
UBA5	Q9GZZ9²^,³	MINT-7947479 I2D: score=1
TJP1	Q07157²^,³, ENSP00000281537⁴	MINT-2984901 I2D: score=3 STRING: ENSP00000281537
CDKN2A	P42771³, ENSP00000355153⁴	I2D: score=1 I2D: score=1 STRING: ENSP00000355153

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	--	--
GO:0006457	protein folding	TAS	--
GO:0007017	microtubule-based process	TAS	12090300
GO:0007018	microtubule-based movement	IEA	--
GO:0030705	cytoskeleton-dependent intracellular transport	TAS	12090300

TUBA1C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TUBA1C available from Tocris Bioscience About this table

Compound	Action	CAS #
XRP44X	Ras-Net pathway inhibitor	[729605-21-4]
Taxol	Promotes assembly and inhibits disassembly of microtubules	[33069-62-4]
Vincristine sulfate	Disrupts microtubules	[2068-78-2]
Vinblastine sulfate	Disrupts microtubules	[143-67-9]
Nocodazole	Microtubule inhibitor	[31430-18-9]

1 HMDB Compound for TUBA1C About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

3 DrugBank Compounds for TUBA1C About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Epothilone B	EPO 906 (see all 3)	152044-54-7	target	--	17139284 17016423
Epothilone D	--	189453-10-9	target	--	17139284 17016423
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about TUBA1C / TBA1C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUBA1C gene:

NM_032704.3

Unigene Cluster for TUBA1C:

Tubulin, alpha 1c

Hs.652390 [show with all ESTs]

Unigene Representative Sequence: AK293589

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000549554 ENST00000550574 ENST00000541364(uc010smh.1) ENST00000549818

ENST00000552448 ENST00000552125 ENST00000301072(uc001rtt.1) ENST00000549183

ENST00000548470

miRNA Products:		OriGene 3'-UTR Clone: TUBA1C Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TUBA1C
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TUBA1C
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBA1C (see all 4) OriGene shRNA RFP: TUBA1C OriGene siRNA: TUBA1C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA1C

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1C (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1C (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA1C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TUBA1C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA1C

Additional cDNA sequence:

AK223024.1 AK293589.1 BC004949.1 BC005946.1 BC011790.1 BC019298.2 BC021088.1 BC033064.1

BC051297.1 BC063036.1 D28390.1

24/169 DOTS entries (see all 169):

DT.95214022 DT.100744545 DT.99926617 DT.100744301 DT.100842020 DT.100744421 DT.121136664 DT.92475285

DT.95320022 DT.100744242 DT.100744456 DT.97869896 DT.92475277 DT.121136256 DT.95174359 DT.121134955

DT.121136350 DT.100856215 DT.92475321 DT.92475326 DT.98083143 DT.100744540 DT.121134834 DT.97869904

19 AceView cDNA sequences:

CR610386 CR624182 CR599275 CR595837 CR599151 CR605574 BC051297 BC019298

BC021088 D28390 CR599812 CR603141 BC011790 CR613152 BC063036 BC005946

NM_032704 BC004949 BC033064

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUBA1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCCCTTG

About this image

TUBA1C expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Endoderm-like cells (Generation of hepato...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TUBA1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUBA1C

SOURCE GeneReport for Unigene cluster: Hs.652390

SABiosciences Expression via Pathway-Focused PCR Array including TUBA1C:

Gap Junctions in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA1C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TUBA1C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA1C

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA1C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1C gene from 8/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	TUBA1C⁶	--	99(a)	1 ↔ 1	GL343198.1(2510602-2513168)
African clawed frog (Xenopus laevis)	Amphibia	BC046841.1²	--	86.81(n)		BC046841.1
zebrafish (Danio rerio)	Actinopterygii	tuba1¹	tubulin, alpha 1	85.23(n) 98(a)		373080 NM_194388.2 NP_919369.2
fruit fly (Drosophila melanogaster)	Insecta	alphaTub85E¹	alpha-Tubulin at 85E	80.25(n) 94.65(a)		41183 NM_079573.4 NP_524297.1
worm (Caenorhabditis elegans)	Secernentea	tba-9¹	Protein TBA-9	71.23(n) 85.65(a)		185538 NM_076154.2 NP_508555.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TUB1¹	Tub1p	64.87(n) 74.83(a)		854889 NP_013625.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TUA2¹	tubulin alpha-2/alpha-4 chain	75.28(n) 85.75(a)		841425 NM_103889.3 NP_175423.1
rice (Oryza sativa)	Liliopsida	Os.9504²	O.sativa mRNA for alpha-tubulin (clone OSTA-274)	79.93(n)		AK069140.1

ENSEMBL Gene Tree for TUBA1C (if available)
TreeFam Gene Tree for TUBA1C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TUBA1C gene

TUBA3C² TUBA4A² TUBA1B² TUBA1A² TUBAL3² TUBA3E² TUBA3D² TUBA8²

18/179 SIMAP similar genes for TUBA1C using alignment to 6 protein entries: TBA1C_HUMAN (see all proteins) (see all similar genes):

TUBA1 TUBA4B TUBA4A FP1523 TUBA1B TUBA1A

NDUFS3 PUS1 TUBA2 TUBA3C TUBA3D TUBA3E

NLN PACRG SH2B3 TM4SF19 TUBA8 CALCOCO2

TUBA1C for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TUBA1C
PGOHUM00000244008 PGOHUM00000261295 PGOHUM00000244705

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11168942^1,2	C,A,	--	46688053(+)	`agtagC/Ttggga`	2	--	us2k¹ int¹		0	--	--	--	--
rs17123645^1,2	C,F,H,	--	46688304(+)	`GCTCAC/TAAACA`	2	--	us2k¹ int¹		13		NA NS EA CSA WA	1558
rs74749085^1,2		--	46688341(+)	`GCTAAA/TTATAT`	2	--	us2k¹ int¹		1		EA	120
rs12304483^1,2		--	46689116(+)	`actccA/Gtctca`	2	--	us2k¹ int¹		0	--	--	--	--
rs11168944^1,2	F,A,	--	46689497(+)	`CCGGGG/AGCGAG`	2	--	us2k¹ int¹		3		WA NA EA	358
rs28365885^1,2	F,	--	46689655(+)	`ACCTCT/CGTCCC`	2	--	us2k¹ nc-transcript-variant		4		MN EA WA	1490
rs4554935^1,2	F,	--	46689697(-)	`aagggC/Gaggaa`	2	--	us2k¹		1		WA	118
rs4554934^1,2	F,H,	--	46689706(-)	`AAGGGG/CAGGAA`	2	--	us2k¹ trp³		4		NS EA	414
rs7306436^1,2	A	--	46689762(+)	`cctccC/Tcttcc`	2	--	us2k¹ trp³		0	--	--	--	--
rs12308571^1,2	F,	--	46691614(+)	`gcgtcG/Atggtg`	2	--	int¹ us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for TUBA1C (49582519 - 49667114 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TUBA1C: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBA1C

DNA2.0 Custom Variant and Variant Library Synthesis for TUBA1C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TUBA1C for disorders About GeneDecksing

11 diseases for TUBA1C: About MalaCards

distal hereditary motor neuropathy distal hereditary motor neuropathy, type ii chondroblastoma neuropathy

endocarditis parkinson's disease gastric cancer myeloma

immunodeficiency malaria neuronitis

1 disease from the University of Copenhagen DISEASES database for TUBA1C:

Osteoblastoma

Export disorders for TUBA1C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TUBA1C gene, integrated from 9 sources (see all 69):
(articles sorted by number of sources associating them with TUBA1C)

Utopia: connect your pdf to the dynamic
world of online information

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Construction of a human full-length cDNA bank. (PubMed id 7821789)^{1, 3} Kato S....Aoki T. (1994)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)¹ Haines D.S....Deshaies R.J. (2012)
A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)¹ Kristensen A.R....Foster L.J. (2012)
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)¹ Aichem A....Groettrup M. (2012)
Characterization of the protein ubiquitination respons e induced by Doxorubicin. (PubMed id 22536838)¹ Mandili G....Turrini F. (2012)
Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)¹ Naji S....Gerace L. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84790	HGNC: 20768	AceView: TUBA6	Ensembl:ENSG00000167553	euGenes: HUgn84790
ECgene: TUBA1C	Kegg: 84790	H-InvDB: TUBA1C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TUBA1C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUBA1C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TUBA1C gene:
Search GeneIP for patents involving TUBA1C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for TUBA1C
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TUBA1C		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TUBA1C
	OriGene Protein Over-expression Lysate for TUBA1C		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TUBA1C		OriGene 3'-UTR Clone for TUBA1C
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1C		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TUBA1C
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for TUBA1C		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TUBA1C		OriGene Custom Protein Services for TUBA1C
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TUBA1C
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TUBA1C
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA1C
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TUBA1C
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TUBA1C
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C

	GenScript Custom Purified and Recombinant Proteins Services for TUBA1C		GenScript cDNA clones with any tag delivered in your preferred vector for TUBA1C
	GenScript Custom Assay Services for TUBA1C		GenScript Custom Superior Antibodies Services for TUBA1C
	GenScript Custom overexpressing Cell Line Services for TUBA1C		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TUBA1C promoter
	Search Chromatin IP Primers for TUBA1C
	RT² qPCR Primer Assay in human, mouse, rat TUBA1C
	Search GNC Networks for TUBA1C
	SABiosciences PCR Arrays including human, mouse, rat TUBA1C

Tocris compounds for TUBA1C

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TUBA1C antibodies
	TUBA1C proteins
	TUBA1C lysates

	Search for Antibodies for TUBA1C at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TUBA1C
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for TUBA1C

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TUBA1C

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TUBA1C
	SwitchGear Promoter luciferase reporter plasmids for TUBA1C

Search ThermoFisher Antibodies for TUBA1C

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TUBA1C gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TUBA1C Gene

tubulin, alpha 1c

Aliases
for TUBA1C gene

Summaries
for TUBA1C gene

Genomic Views
for TUBA1C gene

Proteins
for TUBA1C gene

Protein Domains /
Families
for TUBA1C gene

Function
for TUBA1C gene

Pathways & Interactions
for TUBA1C gene

Drugs & Compounds
for TUBA1C gene

Transcripts
for TUBA1C gene

Expression
for TUBA1C gene

Orthologs
for TUBA1C gene

Paralogs
for TUBA1C gene

Genomic Variants
for TUBA1C gene

Disorders / Diseases
for TUBA1C gene

Publications
for TUBA1C gene

External Searches for TUBA1C gene

Genome Databases showing TUBA1C gene

Other Databases showing TUBA1C gene

Specialized Databases showing TUBA1C gene

Intellectual Property
for TUBA1C gene

Products
for TUBA1C gene

View Random Gene

Advanced Search

Export list of displayed genes

TUBA1C Gene

tubulin, alpha 1c

Aliasesfor TUBA1C gene

Summariesfor TUBA1C gene

Genomic Viewsfor TUBA1C gene

Proteinsfor TUBA1C gene

Protein Domains /Familiesfor TUBA1C gene

Functionfor TUBA1C gene

Pathways & Interactionsfor TUBA1C gene

Drugs & Compoundsfor TUBA1C gene

Transcriptsfor TUBA1C gene

Expression for TUBA1C gene

Orthologsfor TUBA1C gene

Paralogsfor TUBA1C gene

Genomic Variantsfor TUBA1C gene

Disorders / Diseasesfor TUBA1C gene

Publicationsfor TUBA1C gene

External Searches for TUBA1C gene

Genome Databases showing TUBA1C gene

Other Databases showing TUBA1C gene

Specialized Databases showing TUBA1C gene

Intellectual Propertyfor TUBA1C gene

Productsfor TUBA1C gene

View Random Gene

Aliases
for TUBA1C gene

Summaries
for TUBA1C gene

Genomic Views
for TUBA1C gene

Proteins
for TUBA1C gene

Protein Domains /
Families
for TUBA1C gene

Function
for TUBA1C gene

Pathways & Interactions
for TUBA1C gene

Drugs & Compounds
for TUBA1C gene

Transcripts
for TUBA1C gene

Expression
for TUBA1C gene

Orthologs
for TUBA1C gene

Paralogs
for TUBA1C gene

Genomic Variants
for TUBA1C gene

Disorders / Diseases
for TUBA1C gene

Publications
for TUBA1C gene

Intellectual Property
for TUBA1C gene

Products
for TUBA1C gene