Aliases for TUBA1C Gene
Aliases for TUBA1C Gene
External Ids for TUBA1C Gene
- HGNC: 20768
- Entrez Gene: 84790
- Ensembl: ENSG00000167553
- UniProtKB: Q9BQE3
Previous HGNC Symbols for TUBA1C Gene
- TUBA6
Previous GeneCards Identifiers for TUBA1C Gene
- GC12P047908
- GC12P049658
- GC12P046689
- GC12P049582
Summaries for TUBA1C Gene
GeneCards Summary for TUBA1C Gene
TUBA1C (Tubulin Alpha 1c) is a Protein Coding gene. Diseases associated with TUBA1C include Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Signaling in Gap Junctions. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA1B.
UniProtKB/Swiss-Prot for TUBA1C Gene
-
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
-
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).
No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA1C Gene
Genomics for TUBA1C Gene
Regulatory Elements for TUBA1C Gene
Enhancers for TUBA1C Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TUBA1C on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TUBA1C gene promoter:
Regulatory Element Products
Genomic Location for TUBA1C Gene
- Chromosome:
- 12
- Start:
- 49,188,736 bp from pter
- End:
- 49,274,603 bp from pter
- Size:
- 85,868 bases
- Orientation:
- Plus strand
Genomic View for TUBA1C Gene
Genes around TUBA1C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.12 by Ensembl
- 12q13.12 by Entrez Gene
- 12q13.12 by HGNC
TUBA1C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TUBA1C Gene
Proteins for TUBA1C Gene
-
Protein details for TUBA1C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BQE3-TBA1C_HUMAN
- Recommended name:
- Tubulin alpha-1C chain
- Protein Accession:
- Q9BQE3
Protein attributes for TUBA1C Gene
- Size:
- 449 amino acids
- Molecular mass:
- 49895 Da
- Quaternary structure:
-
- Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
Protein Expression for TUBA1C Gene
Post-translational modifications for TUBA1C Gene
- Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
- Detyrosinated tubulin alpha-1C chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
- Methylation of alpha chains at Lys-40 is found in mitotic microtubules and is required for normal mitosis and cytokinesis contributing to genomic stability.
- Nitration of Tyr-449 is irreversible and interferes with normal dynein intracellular distribution.
- Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).
- Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
- Tubulin alpha-1C chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
- Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
- Ubiquitination at posLast=280280 and isoforms=304
- Modification sites at PhosphoSitePlus
Other Protein References for TUBA1C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TUBA1C
- Novus Biologicals Antibodies for TUBA1C
- Invitrogen Antibodies for TUBA1C
- antibodies-online Antibodies for TUBA1C: See all 49
- GeneTex TUBA1C antibody for TUBA1C
-
Santa Cruz Biotechnology (SCBT) Antibodies for TUBA1C
Protein Products
-
OriGene Purified Proteins for TUBA1C
- Search Origene for MassSpec and Protein Over-expression Lysates for TUBA1C
- Origene Custom Protein Services for TUBA1C
- antibodies-online Proteins for TUBA1C: See all 7
- Search antibodies-online for peptides
- Search GeneTex for Proteins for TUBA1C
Assay Products
No data available for DME Specific Peptides for TUBA1C Gene
Domains & Families for TUBA1C Gene
Gene Families for TUBA1C Gene
- HGNC:
Protein Domains for TUBA1C Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for TUBA1C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9BQE3- Family:
-
- Belongs to the tubulin family.
Function for TUBA1C Gene
Molecular function for TUBA1C Gene
- UniProtKB/Swiss-Prot Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | IEA | -- |
| GO:0005198 | structural molecule activity | TAS | 12090300 |
| GO:0005200 | structural constituent of cytoskeleton | IEA | -- |
| GO:0005515 | protein binding | IPI | 22720776 |
| GO:0005525 | GTP binding | IEA | -- |
Phenotypes for TUBA1C Gene
- GenomeRNAi human phenotypes for TUBA1C:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Increased G1 DNA content
- G0/1 arrest
- Decreased shRNA abundance (Z-score < -2)
- Decreased IL-8 secretion
- Decreased viability
- Increased number of mitotic cells
- Increased shRNA abundance (Z-score > 2)
- Decreased West Nile virus (WNV) infection
- Increased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased cell number
- Decreased Hepatitis C virus replication
- Decreased viability of wild-type and TP53 knockout cells
- Increased Nanog expression
- HIV Rev nuclear localization
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TUBA1C
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TUBA1C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TUBA1C gene
- Search ViGene Biosciences for TUBA1C
CRISPR Products
-
OriGene CRISPR knockouts for TUBA1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for TUBA1C
- GenScript: Design CRISPR guide RNA sequences for TUBA1C
miRNA for TUBA1C Gene
- miRTarBase miRNAs that target TUBA1C
miRNA Products
- Search ViGene Biosciences for TUBA1C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TUBA1C
- Browse OriGene Inhibitory RNA Products For TUBA1C
-
ViGene Biosciences ready-to-package AAV shRNAs for TUBA1C gene
Clone Products
- Sino Biological Human cDNA Clone for TUBA1C
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TUBA1C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TUBA1C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TUBA1C
-
ViGene Biosciences adenoviral particle packaged cDNA for TUBA1C gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TUBA1C gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TUBA1C gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBA1C Gene
Localization for TUBA1C Gene
Subcellular locations from UniProtKB/Swiss-Prot for TUBA1C Gene
- Cytoplasm, cytoskeleton.
| Compartment | Confidence |
|---|---|
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 21630459 |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005874 | microtubule | IEA,TAS | 12090300 |
| GO:0005881 | cytoplasmic microtubule | IEA | -- |
Pathways & Interactions for TUBA1C Gene
Pathways by source for TUBA1C Gene
2 BioSystems pathways for TUBA1C Gene
5 KEGG pathways for TUBA1C Gene
10 GeneGo (Thomson Reuters) pathways for TUBA1C Gene
Interacting Proteins for TUBA1C Gene
Selected Interacting proteins:
ENSP00000301072
Q9BQE3-TBA1C_HUMAN
for TUBA1C Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007010 | cytoskeleton organization | IEA | -- |
| GO:0007017 | microtubule-based process | IEA,TAS | 12090300 |
| GO:0030705 | cytoskeleton-dependent intracellular transport | TAS | 12090300 |
| GO:0051301 | cell division | TAS | 12090300 |
Drugs & Compounds for TUBA1C Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Colchicine | Approved | Pharma | Antagonist | Tubulin Inhibitor, Inhibitor of tubulin | 115 | |
| Docetaxel | Approved May 1996, Investigational | Pharma | Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer | 1967 | ||
| 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE | Experimental | Pharma | Target | 0 | ||
| Epothilone B | Experimental, Investigational | Pharma | Target | 67 | ||
| Epothilone D | Experimental, Investigational | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Dolastatin 10 trifluoroacetate |
|
|
|
|||
| MMAE |
|
474645-27-7 |
|
|
(5) Tocris Compounds for TUBA1C Gene
| Compound | Action | Cas Number |
|---|---|---|
| Colchicine | Inhibitor of tubulin | 64-86-8 |
| Docetaxel | Microtubule stabilizer | 114977-28-5 |
| Dolastatin 10 trifluoroacetate | Tubulin polymerization inhibitor | |
| MMAE | Potent dolastatin 10 analog; antitumor | 474645-27-7 |
| Vinblastine sulfate | Disrupts microtubules | 143-67-9 |
Transcripts for TUBA1C Gene
mRNA/cDNA for TUBA1C Gene
- (5) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (19) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for TUBA1C
-
Santa Cruz Biotechnology (SCBT) CRISPR for TUBA1C
- GenScript: Design CRISPR guide RNA sequences for TUBA1C
miRNA Products
- Search ViGene Biosciences for TUBA1C
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for TUBA1C
- Browse OriGene Inhibitory RNA Products For TUBA1C
-
ViGene Biosciences ready-to-package AAV shRNAs for TUBA1C gene
Clone Products
- Sino Biological Human cDNA Clone for TUBA1C
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TUBA1C
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TUBA1C
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for TUBA1C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Endoderm (Gastrulation Derivatives)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for TUBA1C Gene
This gene is overexpressed in Esophagus - Mucosa (x6.4).
This gene is overexpressed in Brain (23.3), Bone (11.3), Fetal Brain (7.7), and Bone marrow stromal cell (6.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TUBA1C Gene
NURSA nuclear receptor signaling pathways regulating expression of TUBA1C Gene:
TUBA1CSOURCE GeneReport for Unigene cluster for TUBA1C Gene:
Hs.652390Evidence on tissue expression from TISSUES for TUBA1C Gene
- Intestine(4.9)
- Skin(4.9)
- Nervous system(4.9)
- Liver(4.7)
- Lung(4.7)
- Bone marrow(4.4)
- Kidney(4.3)
- Stomach(4.2)
- Pancreas(4)
- Bone(3.1)
- Eye(2.9)
- Thyroid gland(2.7)
- Muscle(2.2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for TUBA1C
-
OriGene qPCR primer pairs and template standards for TUBA1C
No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUBA1C Gene
Orthologs for TUBA1C Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TUBA1C 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | -- 35 |
|
ManyToMany | |
| TUBA1C 34 |
|
||||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | TUBA1C 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Tuba1c 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100909441 34 |
|
||
| chicken (Gallus gallus) |
Aves | LOC100857247 34 |
|
||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | TUBA1C 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tuba1c 34 |
|
||
| MGC75684 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | tuba1b 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | alphaTub84B 34 |
|
||
| CG7794 35 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010971 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | Y19D2B.1 35 |
|
OneToMany | |
| tba-2 34 |
|
||||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AFR441C 34 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TUB1 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C16874g 34 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | TUA2 34 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os11g0247300 34 |
|
||
| Os.9504 34 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.812 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09468 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | nda2 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany |
- Species where no ortholog for TUBA1C was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for TUBA1C Gene
Paralogs for TUBA1C Gene
(188) SIMAP similar genes for TUBA1C Gene using alignment to 6 proteins:
- TUBA1
- TUBA4B
- TUBA1A
- TUBA4A
- ZNF114
- FP1523
- TUBA1B
- PUS1
- NDUFS3
- TUBA3D
- TUBA3C
- TUBA2
- TUBA3E
- TM4SF19
- PACRG
- NLN
- SH2B3
- TUBA8
- ZNF85
- ZNF620
- TNNT1
- TMX3
- HINFP
- CALCOCO2
- UBXN4
- TMEM209
- TBL2
- PARVB
- LSM12
- FTSJ2
- ABI2
- PFKFB3
- DKFZp686L04275
- ZMAT1
- UBE2B
- PPP2R5C
- PPIL6
- NEK4
- MRPL45
- MAN2C1
- GCDH
- EIF3G
- DPP9
- DCAF17
- C1orf143
- BIRC3
- ARL6IP5
- AARSD1
- ZNF66
- ZNF546
- RHBG
- PTPLAD1
- PDILT
- NFYC
- DUSP3
- CLTA
- ZNF559
- VSTM1
- SLC24A1
- PGS1
- SNRPF
- ZRSR2
- VPS33A
- UTY
- TCTEX1D2
- SUN3
- NDC80
- MUC20
- IRF5
- IRF2
- IK
- HEXDC
- FANCA
- C11orf80
- ATL2
- ASCC1
- AAMDC
- TAF2
- RQCD1
- RBP7
- HBP1
- MGC16703
- pp12301
- ZNF429
- SUV420H1
- ETFA
- TUBAL3
- ZNF799
- ZNF257
- SYT14
- NR5A2
- FP6778
- EEF1E1
- CATSPERD
- AVGR8
- KIAA1651
- FLJ00047
- COQ5
- ZNF28
- SLC35E3
- RRM1
- LDLRAD3
- FAM193A
- ERMN
- DYNC1LI1
- ARIH1
- ADCK1
- TBCB
- SLMO1
- SEPSECS
- RARS
- PPP5D1
- FRG1
- EIF3K
- C14orf105
- SLC38A6
- SIPA1L3
- RRM2B
- PTPN22
- CDK10
- MST132
- ZNF180
- PARK2
- SH3BP1
- RPS13
- NAE1
- FKBP11
- SEC14L3
- NOSTRIN
- IDNK
- FAM3A
- CSPP1
- BEAN1
- ATF1
- TUBB3
- TUBB2A
- TM2D1
- ZNF554
- DYNC2LI1
- DDX23
- TUBB2B
- ZNF415
- TMEM78
- SLC16A3
- NLRC5
- HEATR6
- CCDC122
- ADRA1A
- TUBB4A
- TUBB6
- RPGRIP1L
- MMADHC
- C21orf37
- TUBB4Q
- GEMIN6
- C13orf45
- ARGFX
- ACTR10
- TUBB
- XTP3TPATP1
- TUBB4B
- TUBB1
- TP63
- TUBB8
- TUBB2C
- GALK2
- DKFZp566F223
- TFR2
- CCNJL
- LINC00999
- GNB2L1
- DUSP11
- C12orf76
- UBE2V2
- C4BPB
- C3orf33
- TRMT2B
- CNN2
- C17orf86
- AAR2
- TUBG1
- SMYD4
- NUP93
- FBLN5
- TUBG2
- NKIRAS2
- RHOA
- TUBE1
Pseudogenes.org Pseudogenes for TUBA1C Gene
Variants for TUBA1C Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000141112 | -- | 49,251,774(+) | TATTT(-/AA)AAAAA | intron-variant | |
| rs1000224719 | -- | 49,265,204(+) | CTCGG(G/T)GCTGG | intron-variant | |
| rs1000225763 | -- | 49,252,635(+) | GGCTG(A/C/G)GCACG | intron-variant | |
| rs1000253064 | -- | 49,258,826(+) | CTCTC(A/G)GCTCA | intron-variant | |
| rs1000306720 | -- | 49,258,155(+) | GCACC(C/T)GGCCT | intron-variant |
Residual Variation Intolerance Score:
25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.38;
27.27% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TUBA1C Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TUBA1C
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBA1C Gene
Disorders for TUBA1C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| distal hereditary motor neuropathy, type ii |
|
|
Search TUBA1C in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TUBA1C
No data available for UniProtKB/Swiss-Prot and Genatlas for TUBA1C Gene
Publications for TUBA1C Gene
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Construction of a human full-length cDNA bank. (PMID: 7821789) Kato S. … Aoki T. (Gene 1994) 2 3 64
- The scaffold protein KSR1, a novel therapeutic target for the treatment of Merlin-deficient tumors. (PMID: 26549023) Zhou L. … Hanemann C.O. (Oncogene 2016) 3 64
- Pooled-matrix protein interaction screens using Barcode Fusion Genetics. (PMID: 27107012) Yachie N. … Roth F.P. (Mol. Syst. Biol. 2016) 3 64
Products for TUBA1C Gene
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Sources for TUBA1C Gene
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