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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TUBA1C Gene

protein-coding GIFtS: 62
GCID: GC12P049658

Tubulin, Alpha 1c

(Previous names: tubulin, alpha 6)
(Previous symbol: TUBA6)

Alzheimer's & Parkinson's Diseases Congress

12 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Tubulin, Alpha 1c¹ ²		Tubulin Alpha-6 Chain² ³
TUBA6¹ ² ³		bcm948²
Tubulin, Alpha 6¹ ²		Tubulin Alpha-1C Chain²
Alpha-Tubulin 6² ³

External Ids:	HGNC: 20768¹	Entrez Gene: 84790²	Ensembl: ENSG00000167553⁷	UniProtKB: Q9BQE3³

Export aliases for TUBA1C gene to outside databases

Previous GC identifers: GC12P047908 GC12P046689

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TUBA1C Gene:

TUBA1C (tubulin, alpha 1c) is a protein-coding gene. Diseases associated with TUBA1C include distal hereditary motor neuropathy, type ii, and osteoblastoma, and among its related super-pathways are Development Slit-Robo signaling and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA1C Gene:

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in

turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits

are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine

cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires

motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end

of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the

spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1C Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NT_029419.12 NC_018923.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TUBA1C gene promoter:
HNF-1A YY1 PPAR-gamma1 CBF-A CBF-B HNF-1 PPAR-gamma2 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUBA1C promoter sequence

Search SABiosciences Chromatin IP Primers for TUBA1C

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA1C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12

TUBA1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA1C gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P049658: view genomic region (about GC identifiers)

Start:	49,582,519 bp from pter	End:	49,667,114 bp from pter
Size:	84,596 bases	Orientation:	plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 (See protein sequence)

Recommended Name: Tubulin alpha-1C chain

Size: 449 amino acids; 49895 Da

Subunit: Dimer of alpha and beta chains

Subcellular location: Cytoplasm, cytoskeleton

Explore the universe of human proteins at neXtProt for TUBA1C: NX_Q9BQE3

Explore proteomics data for TUBA1C at MOPED

Post-translational modifications:

UniProtKB: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by

the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity)

UniProtKB: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate

residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated

due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into

axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the

mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation

levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but

they regulate the assembly and dynamics of axonemal microtubules (Probable)

UniProtKB: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule

motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle

progression or cell differentiation to intracellular trafficking and signaling (By similarity)

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9BQE3

TUBA1C Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins: NP_116093.1

ENSEMBL proteins:

ENSP00000443475 ENSP00000447669 ENSP00000448646 ENSP00000447910 ENSP00000301072

ENSP00000448211

Reactome Protein details: Q9BQE3
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	Browse Proteins at Cloud-Clone Corp.

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005874	microtubule	TAS	12090300
GO:0005881	cytoplasmic microtubule	IEA	--
GO:0015630	microtubule cytoskeleton	IDA	--
GO:0043234	protein complex	--	--

TUBA1C for ontologies About GeneDecksing

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

TUB: Tubulins

5/7 InterPro protein domains (see all 7):

IPR002452 Alpha_tubulin

IPR000217 Tubulin

IPR003008 Tubulin_FtsZ_GTPase

IPR023123 Tubulin_C

IPR008280 Tub_FtsZ_C

Graphical View of Domain Structure for InterPro Entry Q9BQE3

ProtoNet protein and cluster: Q9BQE3

1 Blocks protein domain: IPB002452 Alpha tubulin signature

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3

Similarity: Belongs to the tubulin family

TUBA1C for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TBA1C_HUMAN, Q9BQE3

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on

the beta chain and one at a non-exchangeable site on the alpha chain

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005198	structural molecule activity	TAS	12090300
GO:0005200	structural constituent of cytoskeleton	IEA	--
GO:0005525	GTP binding	IEA	--

TUBA1C for ontologies About GeneDecksing

Phenotypes:
6 GenomeRNAi human phenotypes for TUBA1C:

Cell division defect	Decreased Hepatitis C virus re	Decreased cell number, increas	Decreased viability of wild-ty
Increased gamma-H2AX phosphory	Increased number of mitotic ce

Animal Models:

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for TUBA1C About (see all 26)

See pathways by source

SuperPath

Contained pathways About

Development Slit-Robo signaling

	Development Slit-Robo signaling	0.92			Pathogenic Escherichia coli infection	0.43
	Cytoskeleton remodeling Slit-Robo signaling	0.92			Pathogenic Escherichia coli infection	0.41

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

0.93

Parkin-Ubiquitin Proteasomal System pathway

0.89

Cytoskeleton remodeling Neurofilaments

Cytoskeleton remodeling Neurofilaments

0.91

Cytoplasmic microtubules

0.32

M Phase

Mitotic Anaphase	0.94	M Phase	0.88
Separation of Sister Chromatids	0.94	Mitotic M-M/G1 phases	0.88
Mitotic Metaphase and Anaphase	0.94

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

	Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	0.93			Post-chaperonin tubulin folding pathway	0.67
	Transport of connexons to the plasma membrane	0.93			Recruitment of NuMA to mitotic centrosomes	0.50

Pathways by source See SuperPaths
Show all pathways

5/9 EMD Millipore Pathways for TUBA1C (see all 9)

	Cytoskeleton remodeling Neurofilaments
	Cytoskeleton remodeling Slit-Robo signaling
	Cytoplasmic microtubules
	Cytoskeleton remodeling Reverse signaling by ephrin B
	Cytoskeleton remodeling Keratin filaments

5/10 GeneGo (Thomson Reuters) Pathways for TUBA1C (see all 10)

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Cell cycle Spindle assembly and chromosome separation
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Keratin filaments

2 BioSystems Pathways for TUBA1C

	Parkin-Ubiquitin Proteasomal System pathway
	Pathogenic Escherichia coli infection

5/38 Reactome Pathways for TUBA1C (see all 38)

	L1CAM interactions
	Mitotic Prometaphase
	Membrane Trafficking
	Protein folding
	Recruitment of mitotic centrosome proteins and complexes

3 Kegg Pathways (Kegg details for TUBA1C):

	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection

TUBA1C for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TUBA1C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/698 Interacting proteins for TUBA1C (Q9BQE3^{2, 3} ENSP00000301072⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 698)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAQ	P27348²^,³, ENSP00000238081⁴	MINT-7900157 I2D: score=1 STRING: ENSP00000238081
NSF	P46459²^,³	MINT-7947479 I2D: score=1
UBA5	Q9GZZ9²^,³	MINT-7947479 I2D: score=1
TJP1	Q07157²^,³, ENSP00000281537⁴	MINT-2984901 I2D: score=3 STRING: ENSP00000281537
CDKN2A	P42771³, ENSP00000355153⁴	I2D: score=1 I2D: score=1 STRING: ENSP00000355153

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	--	--
GO:0006184	GTP catabolic process	--	--
GO:0006457	protein folding	TAS	--
GO:0007017	microtubule-based process	TAS	12090300
GO:0030705	cytoskeleton-dependent intracellular transport	TAS	12090300

TUBA1C for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for TUBA1C available from Tocris Bioscience About this table

Compound	Action	CAS #
Vinorelbine ditartrate	Selective mitotic microtubule antagonist	[125317-39-7]
Docetaxel	Microtubule stabilizer	[114977-28-5]
Vinblastine sulfate	Disrupts microtubules	[143-67-9]
Colchicine	Inhibitor of tubulin	[64-86-8]
Epothilone B	Microtubule stabilization agent; promotes tubulin polymerization	[152044-54-7]

1 HMDB Compound for TUBA1C About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

3 DrugBank Compounds for TUBA1C About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Epothilone B	EPO 906 (see all 3)	152044-54-7	target	--	17139284 17016423
Epothilone D	--	189453-10-9	target	--	17139284 17016423
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE	--	--	target	--	10592235

Search CenterWatch for drugs/clinical trials and news about TUBA1C / TBA1C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TUBA1C gene:

NM_032704.3

Unigene Cluster for TUBA1C:

Tubulin, alpha 1c

Hs.652390 [show with all ESTs]

Unigene Representative Sequence: AK293589

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000549554 ENST00000550574 ENST00000541364(uc010smh.1) ENST00000549818

ENST00000552448 ENST00000552125 ENST00000301072(uc001rtt.1) ENST00000549183

ENST00000548470

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Additional mRNA sequence:

AK223024.1 AK293589.1 BC004949.1 BC005946.1 BC011790.1 BC019298.2 BC021088.1 BC033064.1

BC051297.1 BC063036.1 D28390.1

24/170 DOTS entries (see all 170):

DT.95214022 DT.100744545 DT.99926617 DT.100744301 DT.100842020 DT.100744421 DT.121136664 DT.95320022

DT.92475285 DT.100744242 DT.100744456 DT.97869896 DT.92475277 DT.121136256 DT.95174359 DT.121136350

DT.121134955 DT.100856215 DT.92475321 DT.92475326 DT.98083143 DT.100744540 DT.121134834 DT.97869904

19 AceView cDNA sequences:

CR605574 CR595837 CR599151 CR599275 BC011790 CR613152 CR603141 D28390

CR599812 BC021088 CR610386 BC051297 CR624182 BC019298 BC063036 BC004949

NM_032704 BC005946 BC033064

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUBA1C expression in normal human tissues (normalized intensities) TUBA1C embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTGCCCTTG

About this image

TUBA1C expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/2 selected tissues (see all 2) fully expand


Liver (Hepatobiliary System)
Endoderm-like cells (Generation of hepatocytes from human pluripotent stem cells)

Endoderm (Gastrulation Derivatives)
Endoderm-like cells (Generation of hepatocytes from human pluripotent stem cells)

See TUBA1C Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TUBA1C

SOURCE GeneReport for Unigene cluster: Hs.652390

SABiosciences Expression via Pathway-Focused PCR Array including TUBA1C:

Gap Junctions in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1C gene from 9/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tuba1c^{1 , 5}	tubulin, alpha 1C^{1, 5}	93.76(n)¹ 99.33(a)¹		15 (55.61 cM)⁵ 22146¹ NM_009448.4¹ NP_033474.1¹ 99029891⁵
lizard (Anolis carolinensis)	Reptilia	TUBA1C⁶	tubulin, alpha 1c	99(a)	1 ↔ 1	GL343198.1(2510602-2522950)
African clawed frog (Xenopus laevis)	Amphibia	BC046841.1²	--	86.81(n)		BC046841.1
zebrafish (Danio rerio)	Actinopterygii	tuba1¹	tubulin, alpha 1	85.23(n) 98(a)		373080 NM_194388.2 NP_919369.2
fruit fly (Drosophila melanogaster)	Insecta	alphaTub85E¹	alpha-Tubulin at 85E	80.25(n) 94.65(a)		41183 NM_079573.4 NP_524297.1
worm (Caenorhabditis elegans)	Secernentea	tba-9¹	Protein TBA-9	71.23(n) 85.65(a)		185538 NM_076154.2 NP_508555.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TUB1¹	Tub1p	64.87(n) 74.83(a)		854889 NP_013625.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TUA2¹	tubulin alpha-2/alpha-4 chain	75.28(n) 85.75(a)		841425 NM_103889.3 NP_175423.1
rice (Oryza sativa)	Liliopsida	Os.9504²	O.sativa mRNA for alpha-tubulin (clone OSTA-274)	79.93(n)		AK069140.1

ENSEMBL Gene Tree for TUBA1C (if available)
TreeFam Gene Tree for TUBA1C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for TUBA1C gene

TUBA3C² TUBA4A² TUBA1B² TUBA1A² TUBAL3² TUBA3E² TUBA8² TUBA3D²

18/190 SIMAP similar genes for TUBA1C using alignment to 6 protein entries: TBA1C_HUMAN (see all proteins) (see all similar genes):

TUBA1 TUBA4B TUBA1A TUBA4A FP1523 ZNF114

TUBA1B NDUFS3 PUS1 TUBA2 TUBA3C TUBA3D

TUBA3E NLN PACRG SH2B3 TM4SF19 TUBA8

TUBA1C for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for TUBA1C
PGOHUM00000244008 PGOHUM00000261295 PGOHUM00000244705

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190777352^1,2	C	--	49493631(+)	`AGATCG/TCACCA`	1	--	int¹		0	--	--	--	--
rs2335452^1,2	C,F,A,H	--	49493648(-)	`GTCTCG/CCTGGA`	1	--	int¹		6		NS EA NA	632
rs139722306^1,2		--	49493673(+)	`ACGTAC/TATGAA`	1	--	int¹		0	--	--	--	--
rs183161235^1,2		--	49493676(+)	`TACATG/TAATTT`	1	--	int¹		0	--	--	--	--
rs73306263^1,2	C,F	--	49493707(+)	`AATACA/TTGTAT`	1	--	int¹		3		WA CSA	122
rs11168948^1,2	C,F,A,H	--	49493751(+)	`AAGCAG/ATACCA`	1	--	int¹		20		NS EA NA WA CSA	2338
rs12310093^1,2	C,F	--	49494033(+)	`AATTGC/GGGGCG`	1	--	int¹		1		WA	118
rs144383106^1,2		--	49494160(+)	`GCTTTC/TTGGGG`	1	--	int¹		0	--	--	--	--
rs146111173^1,2	C	--	49494238(+)	`CCCAGC/TACTTT`	1	--	int¹		0	--	--	--	--
rs188001559^1,2		--	49494252(+)	`AGGCCA/GAGGTG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TUBA1C (49582519 - 49667114 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for TUBA1C: About this table

Variant ID	Type	Subtype	PubMed ID
nsv507642	CNV	Insertion	20534489
nsv509466	CNV	Insertion	20534489

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TUBA1C for disorders About GeneDecksing

12 diseases for TUBA1C: About MalaCards

distal hereditary motor neuropathy, type ii osteoblastoma distal hereditary motor neuropathy chondroblastoma

endocarditis neuropathy parkinson's disease hepatitis c

gastric cancer hepatocellular carcinoma hepatitis neuronitis

1 disease from the University of Copenhagen DISEASES database for TUBA1C:

Osteoblastoma

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
Genetic Association Database (GAD): TUBA1C

Export disorders for TUBA1C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TUBA1C gene, integrated from 9 sources (see all 84):
(articles sorted by number of sources associating them with TUBA1C)

Utopia: connect your pdf to the dynamic
world of online information

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Construction of a human full-length cDNA bank. (PubMed id 7821789)^{1, 3} Kato S....Aoki T. (1994)
The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)¹ Perez-Hernandez D....Yanez-Mo M. (2013)
Quantitative study of the interactome of PKCz involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)¹ Chen R....Zhang N. (2013)
Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (2013)
A regulatory circuit that involves HR23B and HDAC6 gov erns the biological response to HDAC inhibitors. (PubMed id 23703321)¹ New M....La Thangue N.B. (2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)¹ Haines D.S....Deshaies R.J. (2012)
Proteomic analysis of a4b1 integrin adhesion complexes reveals a-subunit-dependent protein recruitment. (PubMed id 22623428)¹ Byron A....Humphries M.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 84790	HGNC: 20768	AceView: TUBA6	Ensembl:ENSG00000167553	euGenes: HUgn84790
ECgene: TUBA1C	Kegg: 84790	H-InvDB: TUBA1C

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TUBA1C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUBA1C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TUBA1C gene:
Search GeneIP for patents involving TUBA1C

GeneCards and IP:
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TUBA1C Gene

Tubulin, Alpha 1c

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TUBA1C Gene

Tubulin, Alpha 1c

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