Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneAnalytics
- GeneLoc
- GenesLikeMe
- VarElect
- PathCards
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Suite
- Affiliated Databases
  
  Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

TUBA1C Gene

protein-coding GIFtS: 64
GCID: GC12P049582

Tubulin, Alpha 1c

(Previous names: tubulin, alpha 6)
(Previous symbol: TUBA6)

See TUBA1C-related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Tubulin, Alpha 1c¹ ²		Tubulin Alpha-6 Chain² ³
TUBA6¹ ² ³		bcm948²
Tubulin, Alpha 6¹ ²		Tubulin Alpha-1C Chain²
Alpha-Tubulin 6² ³

External Ids:	HGNC: 20768¹	Entrez Gene: 84790²	Ensembl: ENSG00000167553⁷	UniProtKB: Q9BQE3³

ORGUL members:

Export aliases for TUBA1C gene to outside databases

Previous GC identifers: GC12P047908 GC12P049658 GC12P046689

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TUBA1C Gene:

TUBA1C (tubulin, alpha 1c) is a protein-coding gene. Diseases associated with TUBA1C include distal hereditary motor neuropathy, type ii, and osteoblastoma. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site

on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA1C Gene:

Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in

turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits

are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine

cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires

motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end

of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the

spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1C Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence at NCBI GenBank:

NC_000012.11 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the TUBA1C gene promoter:
HNF-1A YY1 PPAR-gamma1 CBF-A CBF-B HNF-1 PPAR-gamma2 CBF(2)
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TUBA1C promoter sequence

Search Chromatin IP Primers for TUBA1C

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBA1C

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q13.12

TUBA1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA1C gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P049582: view genomic region (about GC identifiers)

Start:	49,582,519 bp from pter	End:	49,667,114 bp from pter
Size:	84,596 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3 (See protein sequence)

Recommended Name: Tubulin alpha-1C chain

Size: 449 amino acids; 49895 Da

Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer

diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form

protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule

plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different

protofilament numbers can be found in some organisms and specialized cells

Explore the universe of human proteins at neXtProt for TUBA1C: NX_Q9BQE3

Explore proteomics data for TUBA1C at MOPED

Post-translational modifications:

Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue

by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By

similarity)¹

Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate

residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not

polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin

incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,

axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and

lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such

modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)¹

Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule

motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle

progression or cell differentiation to intracellular trafficking and signaling (By similarity)¹

Ubiquitination² at Lys60, Lys96, Lys112, Lys163, Lys280, Lys304, Lys311, Lys326, Lys336, Lys338,
Lys352, Lys370, Lys394, Lys401

Modification sites at PhosphoSitePlus

See TUBA1C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_116093.1

ENSEMBL proteins:

ENSP00000443475 ENSP00000447669 ENSP00000448646 ENSP00000447910 ENSP00000301072

ENSP00000448211

Reactome Protein details: Q9BQE3

TUBA1C Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein for TUBA1C OriGene Protein Over-expression Lysate for TUBA1C OriGene MassSpec for TUBA1C OriGene Custom Protein Services for TUBA1C
	GenScript Custom Purified and Recombinant Proteins Services for TUBA1C
	Novus Biologicals TUBA1C Protein Novus Biologicals TUBA1C Lysates
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.
	Search eBioscience for Proteins for TUBA1C
	Search GeneTex for Proteins for TUBA1C
	antibodies-online proteins for TUBA1C (6 products)
	antibodies-online peptides for TUBA1C

TUBA1C Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for TUBA1C OriGene Custom Antibody Services for TUBA1C
	Novus Biologicals TUBA1C Antibodies
	Abcam antibodies for TUBA1C (P68366, Q9BQE3)
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibody for TUBA1C
	antibodies-online antibodies for TUBA1C (49 products)

TUBA1C Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for TUBA1C
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TUBA1C
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.
	Search eBioscience for ELISAs for TUBA1C
	antibodies-online kits for TUBA1C (8 products)

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

HGNC Gene Families:

TUB: Tubulins

Selected InterPro protein domains (see all 7):

IPR002452 Alpha_tubulin

IPR000217 Tubulin

IPR003008 Tubulin_FtsZ_GTPase

IPR023123 Tubulin_C

IPR018316 Tubulin/FtsZ_2-layer-sand-dom

Graphical View of Domain Structure for InterPro Entry Q9BQE3

ProtoNet protein and cluster: Q9BQE3

1 Blocks protein domain: IPB002452 Alpha tubulin signature

UniProtKB/Swiss-Prot: TBA1C_HUMAN, Q9BQE3

Similarity: Belongs to the tubulin family

Find genes that share domains with TUBA1C About GenesLikeMe

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TBA1C_HUMAN, Q9BQE3

Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site

on the beta chain and one at a non-exchangeable site on the alpha chain

Gene Ontology (GO): 5 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003924	GTPase activity	IEA	--
GO:0005198	structural molecule activity	TAS	12090300
GO:0005200	structural constituent of cytoskeleton	IEA	--
GO:0005525	GTP binding	IEA	--
GO:0019904	protein domain specific binding	--	--

Find genes that share ontologies with TUBA1C About GenesLikeMe

Phenotypes:
6 GenomeRNAi human phenotypes for TUBA1C:

Cell division defect	Decreased Hepatitis C virus re	Decreased cell number, increas	Decreased viability of wild-ty
Increased gamma-H2AX phosphory	Increased number of mitotic ce

Animal Models:

genOway: Develop your customized and physiologically relevant rodent model for TUBA1C

miRNA Products:		miRTarBase miRNAs that target TUBA1C: hsa-let-7b-5p (MIRT052239), hsa-mir-324-5p (MIRT043045), hsa-mir-296-3p (MIRT038397), hsa-mir-16-5p (MIRT031663), hsa-mir-92a-3p (MIRT049110), hsa-mir-877-3p (MIRT036933), hsa-mir-760 (MIRT036769), hsa-mir-940 (MIRT036595), hsa-mir-221-3p (MIRT046865)

		Block miRNA regulation of human, mouse, rat TUBA1C using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate TUBA1C
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TUBA1C
		Predesigned siRNA for gene silencing in human, mouse, rat TUBA1C

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TUBA1C

Clone Products:		OriGene clones in human, mouse for TUBA1C (see all 7) OriGene ORF clones in mouse, rat for TUBA1C OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704)
		Sino Biological Human cDNA Clone for TUBA1C
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TUBA1C
		Browse ESI BIO Cell Lines and PureStem Progenitors for TUBA1C

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

TBA1C_HUMAN, Q9BQE3: Cytoplasm, cytoskeleton

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
cytoskeleton	5
cytosol	3
nucleus	1

About this image

Gene Ontology (GO): 5 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005874	microtubule	TAS	12090300
GO:0005881	cytoplasmic microtubule	IEA	--
GO:0015630	microtubule cytoskeleton	--	--
GO:0043234	protein complex	--	--

Find genes that share ontologies with TUBA1C About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

SuperPaths for TUBA1C About (see all 11)

See pathways by source

Powered
by

SuperPath

Contained pathways About

Development Slit-Robo signaling

Development Slit-Robo signaling	0.44	Pathogenic Escherichia coli infection	0.41
Neurophysiological process Receptor-mediated axon growth repulsion	0.44	Cell adhesion Gap junctions	0.30
Pathogenic Escherichia coli infection	0.43

Parkin-Ubiquitin Proteasomal System pathway

Parkin-Ubiquitin Proteasomal System pathway

0.96

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

0.96

Protein folding

	Protein folding	0.91			Post-chaperonin tubulin folding pathway	0.00
	Chaperonin-mediated protein folding	0.91

Prefoldin mediated transfer of substrate to CCT/TriC

	Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	0.76			Prefoldin mediated transfer of substrate to CCT/TriC	0.72
	Formation of tubulin folding intermediates by CCT/TriC	0.76

Regulation of CFTR activity (norm and CF)

Regulation of CFTR activity (norm and CF)

0.38

wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)

0.38

Find genes that share SuperPaths with TUBA1C About GenesLikeMe

Pathways by source See SuperPaths
Show all pathways

Selected GeneGo (Thomson Reuters) Pathways for TUBA1C (see all 10)

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Cell cycle Spindle assembly and chromosome separation
	Regulation of CFTR activity (norm and CF)
	Neurophysiological process Receptor-mediated axon growth repulsion
	Cytoskeleton remodeling Keratin filaments

2 BioSystems Pathways for TUBA1C

	Parkin-Ubiquitin Proteasomal System pathway
	Pathogenic Escherichia coli infection

Selected Reactome Pathways for TUBA1C (see all 13)

	Resolution of Sister Chromatid Cohesion
	Prefoldin mediated transfer of substrate to CCT/TriC
	Mitotic Prometaphase
	Translocation of GLUT4 to the plasma membrane
	Recruitment of NuMA to mitotic centrosomes

3 Kegg Pathways (Kegg details for TUBA1C):

	Phagosome
	Gap junction
	Pathogenic Escherichia coli infection

Pathway & Disease-focused RT² Profiler PCR Array including TUBA1C:

Gap Junctions in human mouse rat

Interactions:

Search GeneGlobe Interaction Network for TUBA1C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for TUBA1C (Q9BQE3^{2, 3} ENSP00000301072⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 740)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
YWHAQ	P27348²^,³, ENSP00000238081⁴	MINT-7900157 I2D: score=1 STRING: ENSP00000238081
NSF	P46459²^,³	MINT-7947479 I2D: score=1
UBA5	Q9GZZ9²^,³	MINT-7947479 I2D: score=1
TJP1	Q07157²^,³, ENSP00000281537⁴	MINT-2984901 I2D: score=3 STRING: ENSP00000281537
CDKN2A	P42771³, ENSP00000355153⁴	I2D: score=1 I2D: score=1 STRING: ENSP00000355153

About this table

Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000226	microtubule cytoskeleton organization	--	--
GO:0006184	GTP catabolic process	--	--
GO:0006457	protein folding	TAS	--
GO:0007017	microtubule-based process	TAS	12090300
GO:0030705	cytoskeleton-dependent intracellular transport	TAS	12090300

Find genes that share ontologies with TUBA1C About GenesLikeMe

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for TUBA1C available from Tocris Bioscience About this table

Compound	Action	CAS #
Vinorelbine ditartrate	Selective mitotic microtubule antagonist	[125317-39-7]
Docetaxel	Microtubule stabilizer	[114977-28-5]
Vinblastine sulfate	Disrupts microtubules	[143-67-9]
Colchicine	Inhibitor of tubulin	[64-86-8]
Epothilone B	Microtubule stabilization agent; promotes tubulin polymerization	[152044-54-7]

1 HMDB Compound for TUBA1C About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

3 DrugBank Compounds for TUBA1C About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Epothilone B	EPO 906 (see all 3)	152044-54-7	target	--	17139284 17016423
Epothilone D	--	189453-10-9	target	--	17139284 17016423
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE	--	--	target	--	10592235

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for TUBA1C gene:

NM_032704.3

Unigene Cluster for TUBA1C:

Tubulin, alpha 1c

Hs.652390 [show with all ESTs]

Unigene Representative Sequence: AK293589

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000549554 ENST00000550574 ENST00000541364(uc010smh.1) ENST00000549818

ENST00000552448 ENST00000552125 ENST00000301072(uc001rtt.1) ENST00000549183

ENST00000548470

miRNA Products:		Block miRNA regulation of human, mouse, rat TUBA1C using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate TUBA1C
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TUBA1C
		Predesigned siRNA for gene silencing in human, mouse, rat TUBA1C

Clone Products:		OriGene clones in human, mouse for TUBA1C (see all 7) OriGene ORF clones in mouse, rat for TUBA1C OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TUBA1C (NM_032704)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TUBA1C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C

Primer Products:		OriGene qPCR primer pairs and template standards for TUBA1C OriGene qSTAR qPCR primer pairs in human, mouse for TUBA1C
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TUBA1C
		QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
		QuantiFast Probe-based Assays in human, mouse, rat TUBA1C

Additional mRNA sequence:

AK223024.1 AK293589.1 BC004949.1 BC005946.1 BC011790.1 BC019298.2 BC021088.1 BC033064.1

BC051297.1 BC063036.1 D28390.1

Selected DOTS entries (see all 170):

DT.95214022 DT.100744545 DT.99926617 DT.100744301 DT.100842020 DT.100744421 DT.121136664 DT.95320022

DT.92475285 DT.100744242 DT.100744456 DT.97869896 DT.92475277 DT.121136256 DT.95174359 DT.121136350

DT.121134955 DT.100856215 DT.92475321 DT.92475326 DT.98083143 DT.100744540 DT.121134834 DT.97869904

19 AceView cDNA sequences:

BC021088 CR610386 CR595837 CR599151 CR599275 BC011790 D28390 CR599812

CR624182 CR603141 BC019298 BC051297 CR613152 CR605574 BC063036 BC004949

BC005946 NM_032704 BC033064

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TUBA1C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GCTGCCCTTG

About this image

TUBA1C expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 18) fully expand


Brain (Nervous System)
Cerebral Cortex

Bone (Muscoskeletal System)
Bone Marrow

Endoderm (Gastrulation Derivatives)
Endoderm-like cells

Colon (Gastrointestinal Tract)

Uterus (Reproductive System)

TUBA1C Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TUBA1C Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.652390

Pathway & Disease-focused RT² Profiler PCR Array including TUBA1C:

Gap Junctions in human mouse rat

Primer Products:		OriGene qPCR primer pairs and template standards for TUBA1C OriGene qSTAR qPCR primer pairs in human, mouse for TUBA1C
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat TUBA1C
		QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
		QuantiFast Probe-based Assays in human, mouse, rat TUBA1C

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1C gene from Selected species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tuba1c^{1 , 5}	tubulin, alpha 1C^{1, 5}	93.76(n)¹ 99.33(a)¹		15 (55.61 cM)⁵ 22146¹ NM_009448.4¹ NP_033474.1¹ 99029891⁵
chicken (Gallus gallus)	Aves	LOC100857247¹	tubulin alpha-5 chain-like	84.3(n) 95.98(a)		100857247 XM_004942841.1 XP_004942898.1
lizard (Anolis carolinensis)	Reptilia	TUBA1C⁶	tubulin, alpha 1c	99(a)	1 ↔ 1	GL343198.1(2510602-2522950)
African clawed frog (Xenopus laevis)	Amphibia	BC046841.1²	--	86.81(n)		BC046841.1
zebrafish (Danio rerio)	Actinopterygii	tuba1b¹	tubulin, alpha 1b	85.23(n) 98(a)		373080 NM_194388.2 NP_919369.2
fruit fly (Drosophila melanogaster)	Insecta	alphaTub84B¹	alpha-Tubulin at 84B	82.33(n) 96.88(a)		40848 NM_057424.4 NP_476772.1
worm (Caenorhabditis elegans)	Secernentea	tba-2¹	tba-2	75.76(n) 88.37(a)		173167 NM_001025879.3 NP_001021050.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	TUB1¹	TUB1	64.87(n) 74.83(a)		854889 NP_013625.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TUA2¹	TUA2	75.28(n) 85.75(a)		841425 NM_103889.3 NP_175423.1
rice (Oryza sativa)	Liliopsida	Os.9504²	O.sativa mRNA for alpha-tubulin (clone OSTA-274)	79.93(n)		AK069140.1

ENSEMBL Gene Tree for TUBA1C (if available)
TreeFam Gene Tree for TUBA1C (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

Paralogs for TUBA1C gene

TUBA3C² TUBA4A² TUBA1B² TUBA1A² TUBA3E² TUBA8² TUBA3D²

Selected SIMAP similar genes for TUBA1C using alignment to 6 protein entries: TBA1C_HUMAN (see all proteins) (see all similar genes):

TUBA1 TUBA4B TUBA1A TUBA4A FP1523 ZNF114

TUBA1B NDUFS3 PUS1 TUBA2 TUBA3C TUBA3D

TUBA3E NLN PACRG SH2B3 TM4SF19 TUBA8

Find genes that share paralogs with TUBA1C About GenesLikeMe

3 Pseudogenes.org Pseudogenes for TUBA1C
PGOHUM00000244008 PGOHUM00000261295 PGOHUM00000244705

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190777352^1,2	C	--	49493631(+)	`AGATCG/TCACCA`	1	--	int¹		0	--	--	--	--
rs2335452^1,2	C,F,A,H	--	49493648(-)	`GTCTCG/CCTGGA`	1	--	int¹		6		NS EA NA	632
rs139722306^1,2		--	49493673(+)	`ACGTAC/TATGAA`	1	--	int¹		0	--	--	--	--
rs183161235^1,2		--	49493676(+)	`TACATG/TAATTT`	1	--	int¹		0	--	--	--	--
rs73306263^1,2	C,F	--	49493707(+)	`AATACA/TTGTAT`	1	--	int¹		3		WA CSA	122
rs11168948^1,2	C,F,A,H	--	49493751(+)	`AAGCAG/ATACCA`	1	--	int¹		20		NS EA NA WA CSA	2338
rs12310093^1,2	C,F	--	49494033(+)	`AATTGC/GGGGCG`	1	--	int¹		1		WA	118
rs144383106^1,2		--	49494160(+)	`GCTTTC/TTGGGG`	1	--	int¹		0	--	--	--	--
rs146111173^1,2	C	--	49494238(+)	`CCCAGC/TACTTT`	1	--	int¹		0	--	--	--	--
rs188001559^1,2		--	49494252(+)	`AGGCCA/GAGGTG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TUBA1C (49582519 - 49667114 bp)

Structural Variations
Database of Genomic Variants (DGV) 2 variations for TUBA1C: About this table

Variant ID	Type	Subtype	PubMed ID
nsv507642	CNV	Insertion	20534489
nsv509466	CNV	Insertion	20534489

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TUBA1C

DNA2.0 Custom Variant and Variant Library Synthesis for TUBA1C

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

2 diseases for TUBA1C:
About MalaCards

distal hereditary motor neuropathy, type ii osteoblastoma

1 inferred disease relationship from the University of Copenhagen DISEASES database for TUBA1C:

Osteoblastoma

Find genes that share disorders with TUBA1C About GenesLikeMe

Genetic Association Database (GAD): TUBA1C

Export disorders for TUBA1C gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TUBA1C gene, integrated from 10 sources (see all 86):
(articles sorted by number of sources associating them with TUBA1C)

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (Cell 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
Construction of a human full-length cDNA bank. (PubMed id 7821789)^{1, 3} Kato S....Aoki T. (Gene 1994)
The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. (PubMed id 23463506)¹ Perez-Hernandez D....YA!A+ez-MA^ M. (J. Biol. Chem. 2013)
Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)¹ Chen R....Zhang N. (J. Proteome Res. 2013)
Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)¹ Zanon A....Pichler I. (PLoS ONE 2013)
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)¹ Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
A regulatory circuit that involves HR23B and HDAC6 governs the biological response to HDAC inhibitors. (PubMed id 23703321)¹ New M....La Thangue N.B. (Cell Death Differ. 2013)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. (PubMed id 22337587)¹ Haines D.S....Deshaies R.J. (amp 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84790	HGNC: 20768	AceView: TUBA6	Ensembl:ENSG00000167553	euGenes: HUgn84790
ECgene: TUBA1C	Kegg: 84790	H-InvDB: TUBA1C

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TUBA1C	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TUBA1C gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TUBA1C gene:
Search GeneIP for patents involving TUBA1C

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
About This Section


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for TUBA1C		OriGene RNAi products in human, mouse, rat for TUBA1C
	OriGene qPCR primer pairs and template standards for TUBA1C		OriGene Protein Over-expression Lysate for TUBA1C
	OriGene MassSpec for TUBA1C		OriGene clones in human, mouse for TUBA1C
	OriGene qSTAR qPCR primer pairs in human, mouse for TUBA1C		OriGene Purified Protein for TUBA1C
	OriGene ORF clones in mouse, rat for TUBA1C		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TUBA1C		OriGene Custom Protein Services for TUBA1C

	Block miRNA regulation of human, mouse, rat TUBA1C using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing TUBA1C
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBA1C		Predesigned siRNA for gene silencing in human, mouse, rat TUBA1C
	QuantiFast Probe-based Assays in human, mouse, rat TUBA1C		QuantiTect SYBR Green Assays in human, mouse, rat TUBA1C
	PCR Arrays including human, mouse, rat TUBA1C		Search Chromatin IP Primers for TUBA1C
	Pre-validated RT² qPCR Primer Assay in human, mouse, rat TUBA1C		Search GeneGlobe Interaction Network for TUBA1C
	Regulatory tfbs in TUBA1C promoter

	GenScript Custom Purified and Recombinant Proteins Services for TUBA1C		GenScript cDNA clones with any tag delivered in your preferred vector for TUBA1C
	GenScript Custom Assay Services for TUBA1C		GenScript Custom overexpressing Cell Line Services for TUBA1C
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Tocris compounds for TUBA1C

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for TUBA1C
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TUBA1C antibodies
	TUBA1C proteins
	TUBA1C lysates

	Antibodies for TUBA1C
	See all of Abcam's Antibodies, Kits and Proteins for TUBA1C
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Browse ESI BIO Cell Lines and PureStem Progenitors for TUBA1C

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1C

	Browse SwitchGear 3'UTR luciferase reporter plasmids for TUBA1C
	SwitchGear Promoter luciferase reporter plasmids for TUBA1C

ThermoFisher Antibody for TUBA1C

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1C

Browse compounds at ApexBio

Search Addgene for plasmids for TUBA1C

	Search eBioscience for proteins for TUBA1C
	Search eBioscience for elisas for TUBA1C
	eBioscience FlowRNA Probe Sets

genOway: Develop your customized and physiologically relevant rodent model for TUBA1C

	antibodies-online antibodies for TUBA1C (49 products)
	antibodies-online kits for TUBA1C (8 products)
	antibodies-online peptides for TUBA1C
	antibodies-online proteins for TUBA1C (6 products)

Search GeneTex for proteins for TUBA1C

GeneCards Home - Full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 2 Nov 2014 , 8 Jan 2015 , 3 Feb 2015

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TUBA1C gene at Home site.

Version: 3.12.350 1 Mar 2015
hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4

GeneCards Suite

Advanced Search

Export list of displayed genes

TUBA1C Gene

Tubulin, Alpha 1c

Aliases
for TUBA1C gene

Summaries
for TUBA1C gene

Genomic Views
for TUBA1C gene

Proteins
for TUBA1C gene

TUBA1C Human Recombinant Protein Products:

TUBA1C Antibody Products:

TUBA1C Assay Products:

Domains /
Families
for TUBA1C gene

Function
for TUBA1C gene

Localization
for TUBA1C gene

Pathways & Interactions
for TUBA1C gene

Drugs & Compounds
for TUBA1C gene

Transcripts
for TUBA1C gene

Expression
for TUBA1C gene

Orthologs
for TUBA1C gene

Paralogs
for TUBA1C gene

Genomic Variants
for TUBA1C gene

Disorders / Diseases
for TUBA1C gene

Publications
for TUBA1C gene

External Searches for TUBA1C gene

Genome Databases showing TUBA1C gene

Other Databases showing TUBA1C gene

Specialized Databases showing TUBA1C gene

Intellectual Property
for TUBA1C gene

Products
for TUBA1C gene

View Random Gene

GeneCards Suite

Advanced Search

Export list of displayed genes

TUBA1C Gene

Tubulin, Alpha 1c

Aliasesfor TUBA1C gene

Summariesfor TUBA1C gene

Genomic Viewsfor TUBA1C gene

Proteinsfor TUBA1C gene

TUBA1C Human Recombinant Protein Products:

TUBA1C Antibody Products:

TUBA1C Assay Products:

Domains /Familiesfor TUBA1C gene

Functionfor TUBA1C gene

Localizationfor TUBA1C gene

Pathways & Interactionsfor TUBA1C gene

Drugs & Compoundsfor TUBA1C gene

Transcriptsfor TUBA1C gene

Expression for TUBA1C gene

Orthologsfor TUBA1C gene

Paralogsfor TUBA1C gene

Genomic Variantsfor TUBA1C gene

Disorders / Diseasesfor TUBA1C gene

Publicationsfor TUBA1C gene

External Searches for TUBA1C gene

Genome Databases showing TUBA1C gene

Other Databases showing TUBA1C gene

Specialized Databases showing TUBA1C gene

Intellectual Propertyfor TUBA1C gene

Productsfor TUBA1C gene

View Random Gene

Aliases
for TUBA1C gene

Summaries
for TUBA1C gene

Genomic Views
for TUBA1C gene

Proteins
for TUBA1C gene

Domains /
Families
for TUBA1C gene

Function
for TUBA1C gene

Localization
for TUBA1C gene

Pathways & Interactions
for TUBA1C gene

Drugs & Compounds
for TUBA1C gene

Transcripts
for TUBA1C gene

Expression
for TUBA1C gene

Orthologs
for TUBA1C gene

Paralogs
for TUBA1C gene

Genomic Variants
for TUBA1C gene

Disorders / Diseases
for TUBA1C gene

Publications
for TUBA1C gene

Intellectual Property
for TUBA1C gene

Products
for TUBA1C gene