Aliases for TUBA1C Gene
External Ids for TUBA1C Gene
Previous HGNC Symbols for TUBA1C Gene
Previous GeneCards Identifiers for TUBA1C Gene
GeneCards Summary for TUBA1C Gene
TUBA1C (Tubulin, Alpha 1c) is a Protein Coding gene. Diseases associated with TUBA1C include osteoblastoma and distal hereditary motor neuropathy, type ii. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and EphB-EphrinB Signaling. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA3C.
UniProtKB/Swiss-Prot for TUBA1C Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.