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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TUBA1B Gene

protein-coding   GIFtS: 60
GCID: GC12M049523

Tubulin, Alpha 1b

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tubulin, Alpha 1b1 2     ubiquitous1
Alpha-Tubulin Ubiquitous2 3     K-ALPHA-12
Tubulin Alpha-Ubiquitous Chain2 3     Alpha Tubulin2
Tubulin K-Alpha-12 3     Tubulin Alpha-1B Chain2
alpha1     Tubulin, Alpha, Ubiquitous2
tubulin1     

External Ids:    HGNC: 188091   Entrez Gene: 103762   Ensembl: ENSG000001234167   OMIM: 6025305   UniProtKB: P683633   

Export aliases for TUBA1B gene to outside databases

Previous GC identifers: GC12M047809 GC12M046552


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TUBA1B Gene: 
TUBA1B (tubulin, alpha 1b) is a protein-coding gene. Diseases associated with TUBA1B include pachygyria, and distal hereditary motor neuropathy, type ii, and among its related super-pathways are Development Slit-Robo signaling and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA1B Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TUBA1B gene promoter:
         TBP   C/EBPbeta   p53   HNF-1   HNF-1A   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBA1B promoter sequence
   Search SABiosciences Chromatin IP Primers for TUBA1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TUBA1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

TUBA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049523:  view genomic region     (about GC identifiers)

Start:
49,521,565 bp from pter      End:
49,525,304 bp from pter
Size:
3,740 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363 (See protein sequence)
Recommended Name: Tubulin alpha-1B chain  
Size: 451 amino acids; 50152 Da
Subunit: Dimer of alpha and beta chains
Subcellular location: Cytoplasm, cytoskeleton
1 PDB 3D structure from and Proteopedia for TUBA1B:
2E4H (3D)    
Secondary accessions: P04687 P05209 Q27I68

Explore the universe of human proteins at neXtProt for TUBA1B: NX_P68363

Explore proteomics data for TUBA1B at MOPED 

Post-translational modifications:

  • UniProtKB: Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue
    by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By
    similarity)
  • UniProtKB: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)
  • UniProtKB: Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule
    motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle
    progression or cell differentiation to intracellular trafficking and signaling (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P68363

  • TUBA1B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TUBA1B Protein Expression
    REFSEQ proteins: NP_006073.2  
    ENSEMBL proteins: 
     ENSP00000336799   ENSP00000448045   ENSP00000449325   ENSP00000449460   ENSP00000449748  
     ENSP00000448648  
    Reactome Protein details: P68363
    Human Recombinant Protein Products for TUBA1B: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule TAS12090300
    GO:0005881cytoplasmic microtubule IEA--
    GO:0015630microtubule cytoskeleton IDA--
    GO:0043234protein complex ----

    TUBA1B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TUB: Tubulins

    5/7 InterPro protein domains (see all 7):
     IPR002452 Alpha_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR008280 Tub_FtsZ_C

    Graphical View of Domain Structure for InterPro Entry P68363

    ProtoNet protein and cluster: P68363

    1 Blocks protein domain: IPB002452 Alpha tubulin signature

    UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363
    Similarity: Belongs to the tubulin family


    TUBA1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBA1B_HUMAN, P68363
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IEA--
    GO:0005198structural molecule activity TAS12090300
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding IPI11698390
    GO:0005525GTP binding IEA--
         
    TUBA1B for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TUBA1B:
     Cell division defect  Decreased cell number, increas  Decreased homologous recombina  Decreased viability of wild-ty 
     Increased circadian period len  Increased number of mitotic ce 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TUBA1B About   (see all 32)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Development Slit-Robo signaling
    Development Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.43
    Cytoskeleton remodeling Slit-Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Neurofilaments0.91
    Cytoplasmic microtubules0.32
    4M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    5Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
    Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane0.93
    Post-chaperonin tubulin folding pathway0.67
    Transport of connexons to the plasma membrane0.93
    Recruitment of NuMA to mitotic centrosomes0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for TUBA1B (see all 9)
        Cytoskeleton remodeling Neurofilaments
    Cytoskeleton remodeling Slit-Robo signaling
    Cytoplasmic microtubules
    Cytoskeleton remodeling Reverse signaling by ephrin B
    Cytoskeleton remodeling Keratin filaments


    3 Cell Signaling Technology (CST) Pathways for TUBA1B
        Chromatin Regulation / Acetylation
    Neuroscience
    Cytoskeletal Signaling

    5/10 GeneGo (Thomson Reuters) Pathways for TUBA1B (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    5 BioSystems Pathways for TUBA1B
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection
    Signaling events mediated by HDAC Class II
    Signaling events mediated by HDAC Class III
    Signaling events mediated by PRL


    5/37        Reactome Pathways for TUBA1B (see all 37)
        L1CAM interactions
    Mitotic Prometaphase
    Membrane Trafficking
    Protein folding
    Recruitment of mitotic centrosome proteins and complexes


    3         Kegg Pathways  (Kegg details for TUBA1B):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection


    TUBA1B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TUBA1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/109 Interacting proteins for TUBA1B (P683632, 3 ENSP000003367994) via UniProtKB, MINT, STRING, and/or I2D (see all 109)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756742, 3, ENSP000004089584MINT-8276020 I2D: score=2 STRING: ENSP00000408958
    YWHAZP631042, 3, ENSP000003095034MINT-3297730 I2D: score=1 STRING: ENSP00000309503
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    STARD13Q9Y3M83, ENSP000003387854I2D: score=3 STRING: ENSP00000338785
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0006184GTP catabolic process ----
    GO:0006457protein folding TAS--
    GO:0007017microtubule-based process TAS12090300
    GO:0030705cytoskeleton-dependent intracellular transport TAS12090300

    TUBA1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TUBA1B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for TUBA1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 HMDB Compound for TUBA1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 DrugBank Compounds for TUBA1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Epothilone BEPO 906 (see all 3)152044-54-7target--17139284 17016423
    Epothilone D-- 189453-10-9target--17139284 17016423
    2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE-- --target--10592235

    10/63 Novoseek inferred chemical compound relationships for TUBA1B gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dinitroaniline 71.5 2 12681297 (1), 16913711 (1)
    nocodazole 69.7 13 18485433 (2), 17161375 (1), 8478694 (1), 18592005 (1) (see all 11)
    pironetin 69.5 4 15217613 (3), 17465195 (1)
    paclitaxel 68.9 36 9571153 (4), 10930805 (2), 12649178 (2), 18485433 (2) (see all 23)
    lbh-589 61.1 1 16728695 (1)
    colchicine 59.3 10 2011590 (2), 9500839 (2), 12716939 (1), 17711308 (1) (see all 8)
    ixabepilone 55.7 12 18094432 (3), 15837987 (1)
    epothilone b 53.1 1 18723488 (1)
    suberoylanilide hydroxamic acid 51.5 2 19621389 (2)
    vinblastine 50.5 3 15865430 (1), 2011590 (1), 15917812 (1)

    Search CenterWatch for drugs/clinical trials and news about TUBA1B / TBA1B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for TUBA1B gene: 
    NM_006082.2  

    Unigene Cluster for TUBA1B:

    Tubulin, alpha 1b
    Hs.524390  [show with all ESTs]
    Unigene Representative Sequence: AK094717
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336023(uc001rtm.3) ENST00000332858(uc001rtl.3) ENST00000547765
    ENST00000550367 ENST00000551324 ENST00000549870 ENST00000547476 ENST00000552984

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF081484.1 AK026516.1 AK026632.1 AK056693.1 AK057773.1 AK094717.1 AK098357.1 AK098635.1 
    AK098771.1 AK289354.1 AK293337.1 AY533484.1 BC000696.2 BC001128.1 BC006379.2 BC006481.1 
    BC008659.2 BC009314.2 BC009509.2 BC009512.2 BC009513.2 BC010494.1 BC011572.1 BC015883.2 
    BC017004.1 BC018948.2 BC021564.1 BC030820.1 BC071904.1 DQ400107.1 K00558.1 S62639.1 
    Z36832.1 

    24/227 DOTS entries (see all 227):

    DT.92475285  DT.95320022  DT.92366709  DT.99926637  DT.100848485  DT.100744378  DT.100052773  DT.100744363 
    DT.91934824  DT.100862142  DT.95174416  DT.100744304  DT.102844043  DT.100744270  DT.100744484  DT.92475438 
    DT.121135794  DT.100744530  DT.100744436  DT.121134919  DT.100744333  DT.100769967  DT.99926616  DT.95106020 

    24/279 AceView cDNA sequences (see all 279):

    CR611532 CR621394 CR603274 CR595709 CR616286 CR607620 CR613821 CR601121 
    CR614038 CR615774 CR609944 CR603952 CR590711 CR601948 CR602450 CR617226 
    CR599677 CR609219 CR603766 BC015883 CR610313 CR613561 CR595149 CR598221 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TUBA1B expression in normal human tissues (normalized intensities)      TUBA1B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTACCTGTA
    TUBA1B Expression
    About this image


    TUBA1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 17 entries
             Thalamus
             Substantia Nigra   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Neuron (Nervous System)
             nerve   
     
     Bone (Muscoskeletal System)
             Human fetal bone marrow-derived mesenchymal stromal cells
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer

    See TUBA1B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TUBA1B

    SOURCE GeneReport for Unigene cluster: Hs.524390
        SABiosciences Custom PCR Arrays for TUBA1B
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBA1B gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tuba1b1 , 5 tubulin, alpha 1B1, 5 94.38(n)1
    100(a)1
      15 (55.21 cM)5
    221431  NM_011654.21  NP_035784.11 
     989314255 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC061297.12   -- 87.12(n)    BC061297.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC042319.12   -- 84.93(n)   373080  BC042319.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tba-21 Protein TBA-2 76.34(n)
    88.84(a)
      173167  NM_001025879.2  NP_001021050.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TUA31 tubulin alpha-3/alpha-5 chain 72.07(n)
    83.56(a)
      832097  NM_121982.3  NP_197478.1 
    rice
    (Oryza sativa)
    Liliopsida Os07g05748001 hypothetical protein 77.33(n)
    82.67(a)
      4343694  NM_001066610.1  NP_001060075.1 


    ENSEMBL Gene Tree for TUBA1B (if available)
    TreeFam Gene Tree for TUBA1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TUBA1B gene
    TUBA3C2  TUBA4A2  TUBA1A2  TUBAL32  TUBA3E2  TUBA1C2  TUBA82  TUBA3D2  
    18/29 SIMAP similar genes for TUBA1B using alignment to 7 protein entries:     TBA1B_HUMAN (see all proteins) (see all similar genes):
    TUBA1    TUBA1A    TUBA4A    TUBA1C    TUBA3E    TUBA4B
    DKFZp686L04275    TUBA8    TUBA2    TUBA3C    TUBA3D    TUBB6
    TUBAL3    TUBB3    TUBB4A    TUBB2A    XTP3TPATP1    MGC16703

    TUBA1B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TUBA1B
    PGOHUM00000257918 PGOHUM00000246745


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/189 SNPs in TUBA1B are shown (see all 189)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874123891,2
    --49521146(+) TCTCCC/TAGGCT 1 -- int10--------
    rs1918265391,2
    --49521267(+) CTCAGA/TGGATA 1 -- int10--------
    rs1445752101,2
    --49521348(+) CTTTAA/GATTAG 1 -- int10--------
    rs1484668071,2
    --49521374(+) CACCCC/GCTATG 1 -- int10--------
    rs1829120271,2
    --49521424(+) TCCTGC/GCTTTC 1 -- int10--------
    rs1866781261,2
    --49521458(+) CTAGAA/GGTGCC 1 -- int10--------
    rs1913395731,2
    --49521491(+) ACACCA/GGACTC 1 -- int10--------
    rs1827975531,2
    --49521516(+) ATAGAG/TGAATC 1 -- int10--------
    rs576225401,2
    C,F--49521579(+) TAATGA/GCTTTA 1 -- ut311Minor allele frequency- G:0.05EA 120
    rs27531,2
    C,F,O,A,H--49521672(-) ACAGAT/CGTTAA 1 -- ut31 ese325Minor allele frequency- C:0.45MN NS EA NA WA CSA 2536

    HapMap Linkage Disequilibrium report for TUBA1B (49521565 - 49525304 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TUBA1B: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602530    OMIM disorders: --

    20/56 diseases for TUBA1B (see all 56):    About MalaCards
    pachygyria    distal hereditary motor neuropathy, type ii    distal hereditary motor neuropathy    pulmonary sclerosing hemangioma
    sclerosing hemangioma    cerebral amyloid angiopathy    transient cerebral ischemia    hemangioma
    estrogen-receptor positive breast cancer    bronchiolitis obliterans    bronchiolitis    differentiating neuroblastoma
    breast adenocarcinoma    dengue hemorrhagic fever    gigantism    hemorrhagic fever
    neuroblastoma    ischemia    retinal degeneration    mantle cell lymphoma

    1 disease from the University of Copenhagen DISEASES database for TUBA1B:
    Bronchiolitis obliterans

    TUBA1B for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/27 Novoseek inferred disease relationships for TUBA1B gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung carcinoma 21.3 5 20510079 (3), 11329278 (1), 7543053 (1)
    glioma 18.8 2 18543212 (1), 16181609 (1)
    cancer 17.2 7 19407367 (1), 15033907 (1), 16541425 (1), 20510079 (1)
    glioblastoma 16.1 1 16257120 (1)
    breast cancer 13.8 3 19548283 (1), 18085226 (1), 18424035 (1)
    tumors 12.2 15 9731740 (2), 15837987 (2), 17606971 (1), 18632620 (1) (see all 12)
    leukemia 11.3 2 15937340 (1), 17447750 (1)
    shock 11.2 10 18347185 (1), 18790094 (1), 18607586 (1), 8255174 (1) (see all 7)
    neurofibrillary tangles 10.2 1 18487604 (1)
    alzheimers disease 7.64 7 17336290 (1), 18487604 (1), 19457097 (1), 7479369 (1) (see all 5)


    Export disorders for TUBA1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TUBA1B gene, integrated from 9 sources (see all 501):
    (articles sorted by number of sources associating them with TUBA1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. (PubMed id 6646120)1, 2, 3 Cowan N.J....Cleveland D.W. (1983)
    2. Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. (PubMed id 12054644)1, 3 Banerjee A. (2002)
    5. C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. (PubMed id 8619814)1, 2 Baumann M.H.... Ghiso J. (1996)
    6. Anti-leukaemic effects of two extract types of Lactuc a sativa correlate with the activation of Chk2, induction of p21, downregulatio n of cyclin D1 and acetylation of alpha-tubulin. (PubMed id 20204303)1, 9 Gridling M....Krupitza G. (2010)
    7. alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. (PubMed id 18195004)1, 9 Kawahara K....Masliah E. (2008)
    8. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PubMed id 19409876)1, 9 Wei S.M....Cai J.T. (2009)
    9. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. (PubMed id 11146551)1, 9 Germani A.... Calvo F. (2000)
    10. The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. (PubMed id 7651436)1, 9 Alexandrova N....Zajac-Kaye M. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10376 HGNC: 18809 AceView: K-ALPHA-1 Ensembl:ENSG00000123416 euGenes: HUgn10376
    ECgene: TUBA1B Kegg: 10376 H-InvDB: TUBA1B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TUBA1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TUBA1B gene:
    Search GeneIP for patents involving TUBA1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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