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TUBA1B Gene

protein-coding   GIFtS: 61
GCID: GC12M049523

Tubulin, Alpha 1b

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tubulin, Alpha 1b1 2     ubiquitous1
Alpha-Tubulin Ubiquitous2 3     K-ALPHA-12
Tubulin Alpha-Ubiquitous Chain2 3     Alpha Tubulin2
Tubulin K-Alpha-12 3     Tubulin Alpha-1B Chain2
alpha1     Tubulin, Alpha, Ubiquitous2
tubulin1     

External Ids:    HGNC: 188091   Entrez Gene: 103762   Ensembl: ENSG000001234167   OMIM: 6025305   UniProtKB: P683633   

Export aliases for TUBA1B gene to outside databases

Previous GC identifers: GC12M047809 GC12M046552


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TUBA1B Gene:
TUBA1B (tubulin, alpha 1b) is a protein-coding gene. Diseases associated with TUBA1B include pachygyria, and distal hereditary motor neuropathy, type ii. GO annotations related to this gene include structural molecule activity and GTP binding. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363
Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
on the beta chain and one at a non-exchangeable site on the alpha chain

summary for TUBA1B Gene:
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in
turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits
are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine
cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires
motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end
of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the
spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TUBA1B gene promoter:
         TBP   C/EBPbeta   p53   HNF-1   HNF-1A   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTUBA1B promoter sequence
   Search Chromatin IP Primers for TUBA1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TUBA1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.12   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q13.12

TUBA1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TUBA1B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049523:  view genomic region     (about GC identifiers)

Start:
49,521,565 bp from pter      End:
49,525,304 bp from pter
Size:
3,740 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363 (See protein sequence)
Recommended Name: Tubulin alpha-1B chain  
Size: 451 amino acids; 50152 Da
Subunit: Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer
diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form
protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule
plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different
protofilament numbers can be found in some organisms and specialized cells
1 PDB 3D structure from and Proteopedia for TUBA1B:
2E4H (3D)    
Secondary accessions: P04687 P05209 Q27I68

Explore the universe of human proteins at neXtProt for TUBA1B: NX_P68363

Explore proteomics data for TUBA1B at MOPED

Post-translational modifications: 

  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue
    by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By
    similarity)1
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate
    residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not
    polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin
    incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles,
    axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and
    lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such
    modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable)1
  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule
    motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle
    progression or cell differentiation to intracellular trafficking and signaling (By similarity)1
  • Ubiquitination2 at Lys60, Lys96, Lys112, Lys163, Lys280, Lys304, Lys311, Lys326, Lys336, Lys338,
                                 Lys352, Lys370, Lys394, Lys401
  • Glycosylation2 at Asn380
  • Modification sites at PhosphoSitePlus

  • See TUBA1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006073.2  
    ENSEMBL proteins: 
     ENSP00000336799   ENSP00000448045   ENSP00000449325   ENSP00000449460   ENSP00000449748  
     ENSP00000448648  
    Reactome Protein details: P68363

    TUBA1B Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

    TUBA1B Antibody Products:

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    Abcam antibodies for TUBA1B (P07437, P68363, P68366, Q13885)
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TUB: Tubulins

    Selected InterPro protein domains (see all 7):
     IPR002452 Alpha_tubulin
     IPR000217 Tubulin
     IPR003008 Tubulin_FtsZ_GTPase
     IPR023123 Tubulin_C
     IPR018316 Tubulin/FtsZ_2-layer-sand-dom

    Graphical View of Domain Structure for InterPro Entry P68363

    ProtoNet protein and cluster: P68363

    1 Blocks protein domain: IPB002452 Alpha tubulin signature

    UniProtKB/Swiss-Prot: TBA1B_HUMAN, P68363
    Similarity: Belongs to the tubulin family


    TUBA1B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TBA1B_HUMAN, P68363
    Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site
    on the beta chain and one at a non-exchangeable site on the alpha chain

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003725double-stranded RNA binding IDA--
    GO:0003924GTPase activity IEA--
    GO:0005198structural molecule activity TAS12090300
    GO:0005200structural constituent of cytoskeleton IEA--
    GO:0005515protein binding IPI11698390
         
    TUBA1B for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TUBA1B:
     Cell division defect  Decreased cell number, increas  Decreased homologous recombina  Decreased viability of wild-ty 
     Increased circadian period len  Increased number of mitotic ce 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TUBA1B
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    miRNA
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    miRTarBase miRNAs that target TUBA1B:
    hsa-mir-652-3p (MIRT039463), hsa-mir-320a (MIRT044555), hsa-mir-421 (MIRT039413), hsa-mir-505-5p (MIRT037972), hsa-let-7b-5p (MIRT052015), hsa-mir-107 (MIRT048292), hsa-mir-760 (MIRT036718), hsa-mir-615-3p (MIRT040370), hsa-mir-484 (MIRT042042), hsa-let-7e-5p (MIRT051439), hsa-mir-30a-5p (MIRT049937), hsa-mir-744-5p (MIRT037513), hsa-mir-877-3p (MIRT036931), hsa-mir-182-5p (MIRT047209), hsa-mir-196a-5p (MIRT048190), hsa-mir-10b-5p (MIRT047458), hsa-mir-877-5p (MIRT037246), hsa-mir-3934-5p (MIRT052893), hsa-mir-193b-3p (MIRT016595), hsa-mir-1229-3p (MIRT036296), hsa-mir-324-5p (MIRT043044), hsa-mir-140-3p (MIRT038647), hsa-mir-296-3p (MIRT038384)

    Block miRNA regulation of human, mouse, rat TUBA1B using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TUBA1B
    SwitchGear 3'UTR luciferase reporter plasmidTUBA1B 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: TUBA1B (NM_006082)
    Sino Biological Human cDNA Clone for TUBA1B
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TUBA1B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TUBA1B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TBA1B_HUMAN, P68363: Cytoplasm, cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005874microtubule TAS12090300
    GO:0005881cytoplasmic microtubule IEA--
    GO:0015630microtubule cytoskeleton ----
    GO:0043234protein complex ----

    TUBA1B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TUBA1B About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Pathogenic Escherichia coli infection0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Pathogenic Escherichia coli infection0.43
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    Cytoskeleton remodeling Neurofilaments0.32
    4Protein folding
    Chaperonin-mediated protein folding0.91
    Post-chaperonin tubulin folding pathway0.00
    Protein folding0.91
    5Prefoldin mediated transfer of substrate to CCT/TriC
    Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding0.76
    Formation of tubulin folding intermediates by CCT/TriC0.76

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 Cell Signaling Technology (CST) Pathways for TUBA1B
        Chromatin Regulation / Acetylation
    Neuroscience
    Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for TUBA1B (see all 10)
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Cell cycle Spindle assembly and chromosome separation
    Regulation of CFTR activity (norm and CF)
    Neurophysiological process Receptor-mediated axon growth repulsion
    Cytoskeleton remodeling Keratin filaments

    5 BioSystems Pathways for TUBA1B
        Parkin-Ubiquitin Proteasomal System pathway
    Pathogenic Escherichia coli infection
    Signaling events mediated by PRL
    Signaling events mediated by HDAC Class III
    Signaling events mediated by HDAC Class II


    Selected Reactome Pathways for TUBA1B (see all 12)
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Translocation of GLUT4 to the plasma membrane
    Recruitment of NuMA to mitotic centrosomes
    Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane


    3 Kegg Pathways  (Kegg details for TUBA1B):
        Phagosome
    Gap junction
    Pathogenic Escherichia coli infection


    TUBA1B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TUBA1B
    Interactions:

        GeneGlobe Interaction Network for TUBA1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TUBA1B (P683631, 2, 3 ENSP000003367994) via UniProtKB, MINT, STRING, and/or I2D (see all 163)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TOM1L1O756742, 3, ENSP000004089584MINT-8276020 I2D: score=2 STRING: ENSP00000408958
    YWHAZP631042, 3, ENSP000003095034MINT-3297730 I2D: score=1 STRING: ENSP00000309503
    PIK3R1P279863, ENSP000002743354I2D: score=3 STRING: ENSP00000274335
    STARD13Q9Y3M83, ENSP000003387854I2D: score=3 STRING: ENSP00000338785
    FYNP062413, ENSP000003576564I2D: score=2 STRING: ENSP00000357656
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000226microtubule cytoskeleton organization IEA--
    GO:0006184GTP catabolic process ----
    GO:0006457protein folding TAS--
    GO:0007017microtubule-based process TAS12090300
    GO:0030705cytoskeleton-dependent intracellular transport TAS12090300

    TUBA1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for TUBA1B available from Tocris Bioscience    About this table
    CompoundAction CAS #
    Vinorelbine ditartrateSelective mitotic microtubule antagonist[125317-39-7]
    DocetaxelMicrotubule stabilizer[114977-28-5]
    Vinblastine sulfateDisrupts microtubules[143-67-9]
    ColchicineInhibitor of tubulin[64-86-8]
    Epothilone BMicrotubule stabilization agent; promotes tubulin polymerization[152044-54-7]

    1 HMDB Compound for TUBA1B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 DrugBank Compounds for TUBA1B    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Epothilone BEPO 906 (see all 3)152044-54-7target--17139284 17016423
    Epothilone D-- 189453-10-9target--17139284 17016423
    2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for TUBA1B gene (see all 63)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dinitroaniline 71.5 2 12681297 (1), 16913711 (1)
    nocodazole 69.7 13 18485433 (2), 17161375 (1), 8478694 (1), 18592005 (1) (see all 11)
    pironetin 69.5 4 15217613 (3), 17465195 (1)
    paclitaxel 68.9 36 9571153 (4), 10930805 (2), 12649178 (2), 18485433 (2) (see all 23)
    lbh-589 61.1 1 16728695 (1)
    colchicine 59.3 10 2011590 (2), 9500839 (2), 12716939 (1), 17711308 (1) (see all 8)
    ixabepilone 55.7 12 18094432 (3), 15837987 (1)
    epothilone b 53.1 1 18723488 (1)
    suberoylanilide hydroxamic acid 51.5 2 19621389 (2)
    vinblastine 50.5 3 15865430 (1), 2011590 (1), 15917812 (1)



    TUBA1B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TUBA1B gene: 
    NM_006082.2  

    Unigene Cluster for TUBA1B:

    Tubulin, alpha 1b
    Hs.524390  [show with all ESTs]
    Unigene Representative Sequence: AK094717
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000336023(uc001rtm.3) ENST00000332858(uc001rtl.3) ENST00000547765
    ENST00000550367 ENST00000551324 ENST00000549870 ENST00000547476 ENST00000552984

    miRNA
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    GenScript: all cDNA clones in your preferred vector: TUBA1B (NM_006082)
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TUBA1B
      QuantiFast Probe-based Assays in human, mouse, rat TUBA1B

    Additional mRNA sequence: 

    AF081484.1 AK026516.1 AK026632.1 AK056693.1 AK057773.1 AK094717.1 AK098357.1 AK098635.1 
    AK098771.1 AK289354.1 AK293337.1 AY533484.1 BC000696.2 BC001128.1 BC006379.2 BC006481.1 
    BC008659.2 BC009314.2 BC009509.2 BC009512.2 BC009513.2 BC010494.1 BC011572.1 BC015883.2 
    BC017004.1 BC018948.2 BC021564.1 BC030820.1 BC071904.1 DQ400107.1 K00558.1 S62639.1 
    Z36832.1 

    Selected DOTS entries (see all 227):

    DT.92475285  DT.95320022  DT.92366709  DT.99926637  DT.100848485  DT.100744378  DT.100052773  DT.100744363 
    DT.91934824  DT.100862142  DT.95174416  DT.100744304  DT.102844043  DT.100744270  DT.100744484  DT.92475438 
    DT.121135794  DT.100744530  DT.100744436  DT.121134919  DT.100744333  DT.100769967  DT.99926616  DT.95106020 

    Selected AceView cDNA sequences (see all 279):

    CR615774 CR590002 CR603156 CR625601 CR595709 BC009509 CR605348 CR621408 
    CR590544 CR611376 CR597427 CR617924 CR616286 CR603274 CR615656 CR607910 
    CR594077 CR592846 CR611532 CR609934 CR621370 CR594788 CR604178 CR607987 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TUBA1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTACCTGTA
    TUBA1B Expression
    About this image


    TUBA1B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Endoderm (Gastrulation Derivatives)
             Endoderm-like cells
    TUBA1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TUBA1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524390
        Custom PCR Arrays for TUBA1B
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    OriGene qPCR primer pairs and template standards for TUBA1B
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TUBA1B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tuba1b1 , 5 tubulin, alpha 1B1, 5 94.38(n)1
    100(a)1
      15 (55.21 cM)5
    221431  NM_011654.21  NP_035784.11 
     989314255 
    chicken
    (Gallus gallus)
    Aves TUBAL31 tubulin, alpha-like 3 81.85(n)
    89.75(a)
      416694  NM_001277351.1  NP_001264280.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    100(a)
    many ↔ many
    GL343198.1(2625261-2625557)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BC061297.12   -- 87.12(n)    BC061297.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC042319.12   -- 84.93(n)   373080  BC042319.1 
    worm
    (Caenorhabditis elegans)
    Secernentea tba-91 tba-9 71.99(n)
    87.21(a)
      185538  NM_076154.2  NP_508555.2 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.76132 Vitis vinifera transcribed sequence with strong similarity more 78.95(n)    CF212244.1 


    ENSEMBL Gene Tree for TUBA1B (if available)
    TreeFam Gene Tree for TUBA1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TUBA1B gene
    TUBA3C2  TUBA4A2  TUBA1A2  TUBA3E2  TUBA1C2  TUBA82  TUBA3D2  
    Selected SIMAP similar genes for TUBA1B using alignment to 7 protein entries:     TBA1B_HUMAN (see all proteins) (see all similar genes):
    TUBA1    TUBA1A    TUBA4A    TUBA1C    TUBA3E    TUBA4B
    DKFZp686L04275    TUBA8    TUBA2    TUBA3C    TUBA3D    TUBB6
    TUBAL3    TUBB3    TUBB4A    TUBB2A    XTP3TPATP1    MGC16703

    TUBA1B for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TUBA1B
    PGOHUM00000257918 PGOHUM00000246745


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TUBA1B (see all 189)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874123891,2
    --49521146(+) TCTCCC/TAGGCT 1 -- int10--------
    rs1918265391,2
    --49521267(+) CTCAGA/TGGATA 1 -- int10--------
    rs1445752101,2
    --49521348(+) CTTTAA/GATTAG 1 -- int10--------
    rs1484668071,2
    --49521374(+) CACCCC/GCTATG 1 -- int10--------
    rs1829120271,2
    --49521424(+) TCCTGC/GCTTTC 1 -- int10--------
    rs1866781261,2
    --49521458(+) CTAGAA/GGTGCC 1 -- int10--------
    rs1913395731,2
    --49521491(+) ACACCA/GGACTC 1 -- int10--------
    rs1827975531,2
    --49521516(+) ATAGAG/TGAATC 1 -- int10--------
    rs576225401,2
    C,F--49521579(+) TAATGA/GCTTTA 1 -- ut311Minor allele frequency- G:0.05EA 120
    rs27531,2
    C,F,O,A,H--49521672(-) ACAGAT/CGTTAA 1 -- ut31 ese325Minor allele frequency- C:0.45MN NS EA NA WA CSA 2536

    HapMap Linkage Disequilibrium report for TUBA1B (49521565 - 49525304 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TUBA1B: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TUBA1B
    DNA2.0 Custom Variant and Variant Library Synthesis for TUBA1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602530    OMIM disorders: --

    Selected diseases for TUBA1B (see all 54):    
    About MalaCards
    pachygyria    distal hereditary motor neuropathy, type ii    distal hereditary motor neuropathy    pulmonary sclerosing hemangioma
    sclerosing hemangioma    cerebral amyloid angiopathy    hemangioma    transient cerebral ischemia
    estrogen-receptor positive breast cancer    bronchiolitis obliterans    differentiating neuroblastoma    breast adenocarcinoma
    bronchiolitis    dengue hemorrhagic fever    gigantism    hemorrhagic fever
    neuroblastoma    ischemia    mantle cell lymphoma    squamous cell carcinoma of the head and neck

    1 disease from the University of Copenhagen DISEASES database for TUBA1B:
    Bronchiolitis obliterans

    TUBA1B for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TUBA1B gene (see all 27)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lung carcinoma 21.3 5 20510079 (3), 11329278 (1), 7543053 (1)
    glioma 18.8 2 18543212 (1), 16181609 (1)
    cancer 17.2 7 19407367 (1), 15033907 (1), 16541425 (1), 20510079 (1)
    glioblastoma 16.1 1 16257120 (1)
    breast cancer 13.8 3 19548283 (1), 18085226 (1), 18424035 (1)
    tumors 12.2 15 9731740 (2), 15837987 (2), 17606971 (1), 18632620 (1) (see all 12)
    leukemia 11.3 2 15937340 (1), 17447750 (1)
    shock 11.2 10 18347185 (1), 18790094 (1), 18607586 (1), 8255174 (1) (see all 7)
    neurofibrillary tangles 10.2 1 18487604 (1)
    alzheimers disease 7.64 7 17336290 (1), 18487604 (1), 19457097 (1), 7479369 (1) (see all 5)


    Export disorders for TUBA1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TUBA1B gene, integrated from 10 sources (see all 507):
    (articles sorted by number of sources associating them with TUBA1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. (PubMed id 6646120)1, 2, 3 Cowan N.J.... Cleveland D.W. (Mol. Cell. Biol. 1983)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. (PubMed id 12054644)1, 3 Banerjee A. (Biochem. Biophys. Res. Commun. 2002)
    4. C-terminal fragments of alpha- and beta-tubulin form amyloid fibrils in vitro and associate with amyloid deposits of familial cerebral amyloid angiopathy, British type. (PubMed id 8619814)1, 2 Baumann M.H.... Ghiso J. (Biochem. Biophys. Res. Commun. 1996)
    5. Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of alpha-tubulin. (PubMed id 20204303)1, 9 Gridling M....Krupitza G. (Oncol. Rep. 2010)
    6. alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. (PubMed id 18195004)1, 9 Kawahara K....Masliah E. (J. Biol. Chem. 2008)
    7. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PubMed id 19409876)1, 9 Wei S.M.... Cai J.T. (Biochem. Biophys. Res. Commun. 2009)
    8. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. (PubMed id 11146551)1, 9 Germani A.... Calvo F. (Oncogene 2000)
    9. The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. (PubMed id 7651436)1, 9 Alexandrova N....Zajac-Kaye M. (Mol. Cell. Biol. 1995)
    10. Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast. (PubMed id 19215229)1, 9 Niu Y....Zhang F. (Cancer Sci. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10376 HGNC: 18809 AceView: K-ALPHA-1 Ensembl:ENSG00000123416 euGenes: HUgn10376
    ECgene: TUBA1B Kegg: 10376 H-InvDB: TUBA1B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TUBA1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TUBA1B gene:
    Search GeneIP for patents involving TUBA1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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