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Aliases for TUBA1B Gene

Aliases for TUBA1B Gene

  • Tubulin Alpha 1b 2 3 5
  • Tubulin Alpha-Ubiquitous Chain 3 4
  • Tubulin, Alpha, Ubiquitous 2 3
  • Alpha-Tubulin Ubiquitous 3 4
  • Tubulin K-Alpha-1 3 4
  • Tubulin Alpha-1B Chain 3
  • Alpha Tubulin 3
  • K-ALPHA-1 3

External Ids for TUBA1B Gene

Previous GeneCards Identifiers for TUBA1B Gene

  • GC12M047809
  • GC12M049523
  • GC12M046552

Summaries for TUBA1B Gene

GeneCards Summary for TUBA1B Gene

TUBA1B (Tubulin Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include Kenny-Caffey Syndrome and Hypoparathyroidism-Retardation-Dysmorphism Syndrome. Among its related pathways are Development Slit-Robo signaling and EphB-EphrinB Signaling. GO annotations related to this gene include GTP binding and structural molecule activity.

UniProtKB/Swiss-Prot for TUBA1B Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Tocris Summary for TUBA1B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBA1B Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA1B Gene

Genomics for TUBA1B Gene

Regulatory Elements for TUBA1B Gene

Enhancers for TUBA1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F049819 1 Ensembl ENCODE 4.9 -689.5 -689480 2.4 MAFG GABPA ZNF316 MAFF GATA3 ZNF692 PRDM10 ZBTB33 MAFK EMSY TUBA1B ASIC1 NMTRQ-TTG6-1 BCDIN3D-AS1
GH12F049263 0.2 ENCODE 4.7 -135.0 -135008 6.6 CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 ZFP41 MEF2D CCNT1 DDX23 KANSL2 LOC390314 PRKAG1 C1QL4 BCDIN3D CACNB3 CERS5 PRPH
GH12F048809 0.5 Ensembl ENCODE 4.6 +318.2 318205 6.7 HDGF PKNOX1 MLX ARID4B SIN3A ZNF2 ZNF207 ZNF143 FOS KLF13 DDX23 CCNT1 LOC390314 SENP1 CACNB3 KANSL2 LOC101927267 TUBA1B ENSG00000207467
GH12F049230 1.5 FANTOM5 Ensembl ENCODE 4.3 -101.4 -101444 5.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143 TUBA1C TUBA1A CCNT1 KANSL2 PRKAG1 RHEBL1 FAM186B LOC105369760 TUBA1B LMBR1L
GH12F049247 0.5 FANTOM5 4.2 -115.8 -115833 0.2 PRDM1 TUBA1A TUBA1C PRPH C1QL4 KMT2D TUBA1B ENSG00000258101 ENSG00000274017
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TUBA1B on UCSC Golden Path with GeneCards custom track

Promoters for TUBA1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000430094 -179 3401 CREB3L1 MLX YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548

Genomic Location for TUBA1B Gene

Chromosome:
12
Start:
49,127,782 bp from pter
End:
49,131,521 bp from pter
Size:
3,740 bases
Orientation:
Minus strand

Genomic View for TUBA1B Gene

Genes around TUBA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA1B Gene

Proteins for TUBA1B Gene

  • Protein details for TUBA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68363-TBA1B_HUMAN
    Recommended name:
    Tubulin alpha-1B chain
    Protein Accession:
    P68363
    Secondary Accessions:
    • P04687
    • P05209
    • Q27I68
    • Q8WU19

    Protein attributes for TUBA1B Gene

    Size:
    451 amino acids
    Molecular mass:
    50152 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Three dimensional structures from OCA and Proteopedia for TUBA1B Gene

    Alternative splice isoforms for TUBA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBA1B Gene

Post-translational modifications for TUBA1B Gene

  • Acetylation of alpha chains at Lys-40 is located inside the microtubule lumen. This modification has been correlated with increased microtubule stability, intracellular transport and ciliary assembly.
  • Detyrosinated tubulin alpha-1B chain: Detyrosination is involved in metaphase plate congression by guiding chromosomes during mitosis: detyrosination promotes interaction with CENPE, promoting pole-proximal transport of chromosomes toward the equator (PubMed:25908662). Detyrosination increases microtubules-dependent mechanotransduction in dystrophic cardiac and skeletal muscle. In cardiomyocytes, detyrosinated microtubules are required to resist to contractile compression during contraction: detyrosination promotes association with desmin (DES) at force-generating sarcomeres, leading to buckled microtubules and mechanical resistance to contraction (By similarity).
  • Nitration of Tyr-451 is irreversible and interferes with normal dynein intracellular distribution.
  • Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable).
  • Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866).
  • Tubulin alpha-1B chain: Tyrosination promotes microtubule interaction with CAP-Gly domain-containing proteins such as CLIP1, CLIP2 and DCTN1 (By similarity). Tyrosination regulates the initiation of dynein-dynactin motility via interaction with DCTN1, which brings the dynein-dynactin complex into contact with microtubules (PubMed:26972003). In neurons, tyrosinated tubulins mediate the initiation of retrograde vesicle transport (By similarity).
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Ubiquitination at Lys 326 and Lys 370
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBA1B Gene

No data available for DME Specific Peptides for TUBA1B Gene

Domains & Families for TUBA1B Gene

Gene Families for TUBA1B Gene

Suggested Antigen Peptide Sequences for TUBA1B Gene

Graphical View of Domain Structure for InterPro Entry

P68363

UniProtKB/Swiss-Prot:

TBA1B_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA1B: view

Function for TUBA1B Gene

Molecular function for TUBA1B Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Gene Ontology (GO) - Molecular Function for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 12090300
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 11698390
genes like me logo Genes that share ontologies with TUBA1B: view
genes like me logo Genes that share phenotypes with TUBA1B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBA1B Gene

Localization for TUBA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA1B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBA1B Gene COMPARTMENTS Subcellular localization image for TUBA1B gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA,TAS 12090300
GO:0005881 cytoplasmic microtubule IEA --
GO:0043209 myelin sheath IEA --
genes like me logo Genes that share ontologies with TUBA1B: view

Pathways & Interactions for TUBA1B Gene

genes like me logo Genes that share pathways with TUBA1B: view

SIGNOR curated interactions for TUBA1B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007010 cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA,TAS 12090300
GO:0030705 cytoskeleton-dependent intracellular transport TAS 12090300
GO:0051301 cell division TAS 12090300
genes like me logo Genes that share ontologies with TUBA1B: view

Drugs & Compounds for TUBA1B Gene

(40) Drugs for TUBA1B Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes, Microtubule stabilizer 1918
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 111
Epothilone B Experimental, Investigational Pharma Target 67
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Experimental Pharma Target 0
Epothilone D Experimental, Investigational Pharma Target 0

(33) Additional Compounds for TUBA1B Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolastatin 10 trifluoroacetate
MMAE
474645-27-7

(5) Tocris Compounds for TUBA1B Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Docetaxel Microtubule stabilizer 114977-28-5
Dolastatin 10 trifluoroacetate Tubulin polymerization inhibitor
MMAE Potent dolastatin 10 analog; antitumor 474645-27-7
Vinblastine sulfate Disrupts microtubules 143-67-9

(4) ApexBio Compounds for TUBA1B Gene

Compound Action Cas Number
Docetaxel Microtubulin disassembly inhibitor 114977-28-5
Epothilone A Microtubule stabilizing macrolide 152044-53-6
Epothilone B (EPO906, Patupilone) Microtubule stabilizing macrolide 152044-54-7
MPC 6827 hydrochloride Potent microtubule inhibitor 917369-31-4
genes like me logo Genes that share compounds with TUBA1B: view

Transcripts for TUBA1B Gene

Unigene Clusters for TUBA1B Gene

Tubulin, alpha 1b:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA1B Gene

No ASD Table

Relevant External Links for TUBA1B Gene

GeneLoc Exon Structure for
TUBA1B
ECgene alternative splicing isoforms for
TUBA1B

Expression for TUBA1B Gene

mRNA expression in normal human tissues for TUBA1B Gene

Protein differential expression in normal tissues from HIPED for TUBA1B Gene

This gene is overexpressed in Bone (29.6) and Brain (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TUBA1B Gene



Protein tissue co-expression partners for TUBA1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TUBA1B Gene:

TUBA1B

SOURCE GeneReport for Unigene cluster for TUBA1B Gene:

Hs.524390
genes like me logo Genes that share expression patterns with TUBA1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TUBA1B Gene

Orthologs for TUBA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 35
  • 100 (a)
ManyToMany
LOC610636 34
  • 85.37 (n)
oppossum
(Monodelphis domestica)
Mammalia TUBA1B 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBA1B 34 35
  • 99.41 (n)
cow
(Bos Taurus)
Mammalia TUBA1B 34 35
  • 95.64 (n)
mouse
(Mus musculus)
Mammalia Tuba1b 34 16 35
  • 94.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TUBAL3 34
  • 81.85 (n)
-- 35
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 100 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tuba4a 34
  • 87.21 (n)
zebrafish
(Danio rerio)
Actinopterygii tuba2 34 35
  • 82.63 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.460 34
worm
(Caenorhabditis elegans)
Secernentea Y19D2B.1 35
  • 82 (a)
OneToMany
tba-9 34
  • 71.99 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7613 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
ManyToMany
-- 35
  • 49 (a)
ManyToMany
Species where no ortholog for TUBA1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBA1B Gene

ENSEMBL:
Gene Tree for TUBA1B (if available)
TreeFam:
Gene Tree for TUBA1B (if available)

Paralogs for TUBA1B Gene

No data available for Paralogs for TUBA1B Gene

Variants for TUBA1B Gene

Sequence variations from dbSNP and Humsavar for TUBA1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10160974 -- 49,128,962(+) ATGTA(A/G)TATTT intron-variant
rs10161356 -- 49,129,399(+) GAGGA(A/G)GGAGA intron-variant
rs1057072 -- 49,129,266(-) GACCT(C/T)GTGTT reference, synonymous-codon
rs1057548 -- 49,128,822(+) TTGGA(C/T)TTCTT reference, synonymous-codon
rs1057725 -- 49,128,795(-) TACCC(A/G)GCACC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TUBA1B Gene

Variant ID Type Subtype PubMed ID
nsv975485 CNV duplication 23825009

Variation tolerance for TUBA1B Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBA1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUBA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUBA1B Gene

Disorders for TUBA1B Gene

MalaCards: The human disease database

(5) MalaCards diseases for TUBA1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kenny-caffey syndrome
  • kenny syndrome
hypoparathyroidism-retardation-dysmorphism syndrome
  • hrd syndrome
distal hereditary motor neuropathy, type ii
  • spinal muscular atrophy, jerash type
pachygyria
  • broad gyri of cerebrum
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TUBA1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBA1B
genes like me logo Genes that share disorders with TUBA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBA1B Gene

Publications for TUBA1B Gene

  1. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. (PMID: 6646120) Cowan N.J. … Cleveland D.W. (Mol. Cell. Biol. 1983) 2 3 4 64
  2. Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of alpha-tubulin. (PMID: 20204303) Gridling M. … Krupitza G. (Oncol. Rep. 2010) 3 22 64
  3. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PMID: 19409876) Wei S.M. … Cai J.T. (Biochem. Biophys. Res. Commun. 2009) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. (PMID: 12054644) Banerjee A. (Biochem. Biophys. Res. Commun. 2002) 2 3 64

Products for TUBA1B Gene

Sources for TUBA1B Gene

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