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Aliases for TUBA1B Gene

Aliases for TUBA1B Gene

  • Tubulin, Alpha 1b 2 3
  • Tubulin Alpha-Ubiquitous Chain 3 4
  • Alpha-Tubulin Ubiquitous 3 4
  • Tubulin K-Alpha-1 3 4
  • Tubulin, Alpha, Ubiquitous 3
  • Tubulin Alpha-1B Chain 3
  • Alpha Tubulin 3
  • Ubiquitous 2
  • K-ALPHA-1 3
  • Tubulin 2
  • Alpha 2

External Ids for TUBA1B Gene

Summaries for TUBA1B Gene

GeneCards Summary for TUBA1B Gene

TUBA1B (Tubulin, Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include pachygyria and distal hereditary motor neuropathy, type ii. Among its related pathways are Cytoskeletal Signaling and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA3C.

UniProtKB/Swiss-Prot for TUBA1B Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Tocris Summary for TUBA1B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.

Gene Wiki entry for TUBA1B Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA1B Gene

Genomics for TUBA1B Gene

Genomic Location for TUBA1B Gene

Start:
49,127,782 bp from pter
End:
49,131,521 bp from pter
Size:
3,740 bases
Orientation:
Minus strand

Genomic View for TUBA1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TUBA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA1B Gene

Regulatory Elements for TUBA1B Gene

Proteins for TUBA1B Gene

  • Protein details for TUBA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68363-TBA1B_HUMAN
    Recommended name:
    Tubulin alpha-1B chain
    Protein Accession:
    P68363
    Secondary Accessions:
    • P04687
    • P05209
    • Q27I68
    • Q8WU19

    Protein attributes for TUBA1B Gene

    Size:
    451 amino acids
    Molecular mass:
    50152 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Three dimensional structures from OCA and Proteopedia for TUBA1B Gene

    Alternative splice isoforms for TUBA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBA1B Gene

Proteomics data for TUBA1B Gene at MOPED

Post-translational modifications for TUBA1B Gene

  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys60, Lys96, Lys112, Lys163, Lys280, Lys304, Lys311, Lys326, Lys336, Lys338, Lys352, Lys370, Lys394, and Lys401
  • Glycosylation at Asn380

Other Protein References for TUBA1B Gene

No data available for DME Specific Peptides for TUBA1B Gene

Domains for TUBA1B Gene

Gene Families for TUBA1B Gene

HGNC:
  • TUB :Tubulins

UniProtKB/Swiss-Prot:

TBA1B_HUMAN
Family:
  • Belongs to the tubulin family.:
    • P68363
genes like me logo Genes that share domains with TUBA1B: view

Function for TUBA1B Gene

Molecular function for TUBA1B Gene

UniProtKB/Swiss-Prot Function: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain

Gene Ontology (GO) - Molecular Function for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003725 double-stranded RNA binding IDA 21266579
GO:0003924 GTPase activity IEA --
GO:0005198 structural molecule activity TAS 12090300
GO:0005200 structural constituent of cytoskeleton IEA --
GO:0005515 protein binding IPI 11698390
genes like me logo Genes that share ontologies with TUBA1B: view
genes like me logo Genes that share phenotypes with TUBA1B: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TUBA1B Gene

Localization for TUBA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA1B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBA1B Gene COMPARTMENTS Subcellular localization image for TUBA1B gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule TAS 12090300
GO:0005881 cytoplasmic microtubule IEA --
GO:0043234 protein complex --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TUBA1B: view

Pathways for TUBA1B Gene

genes like me logo Genes that share pathways with TUBA1B: view

Gene Ontology (GO) - Biological Process for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0006184 obsolete GTP catabolic process --
GO:0006457 protein folding TAS --
GO:0007017 microtubule-based process TAS 12090300
GO:0030705 cytoskeleton-dependent intracellular transport TAS 12090300
genes like me logo Genes that share ontologies with TUBA1B: view

Compounds for TUBA1B Gene

(5) Tocris Compounds for TUBA1B Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin [64-86-8]
Docetaxel Microtubule stabilizer [114977-28-5]
Epothilone B Microtubule stabilization agent; promotes tubulin polymerization [152044-54-7]
Vinblastine sulfate Disrupts microtubules [143-67-9]
Vinorelbine ditartrate Selective mitotic microtubule antagonist [125317-39-7]

(1) HMDB Compounds for TUBA1B Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(3) Drugbank Compounds for TUBA1B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
target
Epothilone B
  • EPO 906
152044-54-7 target
Epothilone D
189453-10-9 target

(63) Novoseek inferred chemical compound relationships for TUBA1B Gene

Compound -log(P) Hits PubMed IDs
dinitroaniline 71.5 2
nocodazole 69.7 12
pironetin 69.5 4
paclitaxel 68.9 29
lbh-589 61.1 1
genes like me logo Genes that share compounds with TUBA1B: view

Transcripts for TUBA1B Gene

Unigene Clusters for TUBA1B Gene

Tubulin, alpha 1b:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA1B Gene

No ASD Table

Relevant External Links for TUBA1B Gene

GeneLoc Exon Structure for
TUBA1B
ECgene alternative splicing isoforms for
TUBA1B

Expression for TUBA1B Gene

mRNA expression in normal human tissues for TUBA1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TUBA1B Gene

SOURCE GeneReport for Unigene cluster for TUBA1B Gene Hs.524390

genes like me logo Genes that share expressions with TUBA1B: view

Orthologs for TUBA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TUBA1B 36
  • 99.41 (n)
  • 99.78 (a)
TUBA1B 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TUBA1B 36
  • 95.64 (n)
  • 100 (a)
TUBA1B 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 100 (a)
ManyToMany
LOC610636 36
  • 85.37 (n)
  • 98.67 (a)
mouse
(Mus musculus)
Mammalia Tuba1b 36
  • 94.38 (n)
  • 100 (a)
Tuba1b 16
Tuba1b 37
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TUBA1B 37
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 94 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 57 (a)
OneToMany
TUBAL3 36
  • 81.85 (n)
  • 89.75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 100 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tuba4a 36
  • 87.21 (n)
  • 100 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.460 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
tuba2 36
  • 82.63 (n)
  • 98.23 (a)
tuba2 37
  • 98 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea tba-9 36
  • 71.99 (n)
  • 87.21 (a)
Y19D2B.1 37
  • 82 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7613 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 49 (a)
ManyToMany
-- 37
  • 53 (a)
ManyToMany
Species with no ortholog for TUBA1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBA1B Gene

ENSEMBL:
Gene Tree for TUBA1B (if available)
TreeFam:
Gene Tree for TUBA1B (if available)

Paralogs for TUBA1B Gene

Paralogs for TUBA1B Gene

Pseudogenes.org Pseudogenes for TUBA1B Gene

genes like me logo Genes that share paralogs with TUBA1B: view

Variants for TUBA1B Gene

Sequence variations from dbSNP and Humsavar for TUBA1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2753 -- 49,127,889(-) ACAGA(C/T)GTTAA utr-variant-3-prime
rs706799 -- 49,128,246(-) ATCAA(C/T)TACCA reference, synonymous-codon
rs731350 -- 49,130,804(-) CTGCG(C/G)TTTGC intron-variant
rs755231 -- 49,129,028(+) CATAT(C/T)TCACT intron-variant
rs1057072 -- 49,129,266(-) GACCT(C/T)GTGTT synonymous-codon, reference

Relevant External Links for TUBA1B Gene

HapMap Linkage Disequilibrium report
TUBA1B

No data available for Structural Variations from Database of Genomic Variants (DGV) for TUBA1B Gene

Disorders for TUBA1B Gene

(1) University of Copenhagen DISEASES for TUBA1B Gene

(27) Novoseek inferred disease relationships for TUBA1B Gene

Disease -log(P) Hits PubMed IDs
lung carcinoma 21.3 5
glioma 18.8 2
cancer 17.2 4
glioblastoma 16.1 1
breast cancer 13.8 3
genes like me logo Genes that share disorders with TUBA1B: view

No data available for UniProtKB/Swiss-Prot for TUBA1B Gene

Publications for TUBA1B Gene

  1. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. (PMID: 6646120) Cowan N.J. … Cleveland D.W. (Mol. Cell. Biol. 1983) 2 3 4
  2. Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of alpha-tubulin. (PMID: 20204303) Gridling M. … Krupitza G. (Oncol. Rep. 2010) 3 23
  3. cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins. (PMID: 18790094) Russo A. … Russo G. (Biochim. Biophys. Acta 2008) 3 23
  4. Increased expression of centrosomal alpha, gamma-tubulin in atypical ductal hyperplasia and carcinoma of the breast. (PMID: 19215229) Niu Y. … Zhang F. (Cancer Sci. 2009) 3 23
  5. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PMID: 19409876) Wei S.M. … Cai J.T. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for TUBA1B Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TUBA1B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TUBA1B
    • Block miRNA regulation of TUBA1B using miScript Target Protectors

    Sources for TUBA1B Gene

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