Aliases for TUBA1B Gene
External Ids for TUBA1B Gene
GeneCards Summary for TUBA1B Gene
TUBA1B (Tubulin, Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include pachygyria and distal hereditary motor neuropathy, type ii. Among its related pathways are Cytoskeletal Signaling and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA3C.
UniProtKB/Swiss-Prot for TUBA1B Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized, at one end alpha-subunits are exposed (-) and at the other beta-subunits are exposed (+). Microtubules act as a scaffold to determine cell shape, and provide a backbone for cell organelles and vesicles to move on, a process that requires motor proteins. The major microtubule motor proteins are kinesin, which generally moves towards the (+) end of the microtubule, and dynein, which generally moves towards the (-) end. Microtubules also form the spindle fibers for separating chromosomes during mitosis.