Aliases for TUBA1B Gene
External Ids for TUBA1B Gene
Previous GeneCards Identifiers for TUBA1B Gene
GeneCards Summary for TUBA1B Gene
TUBA1B (Tubulin, Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include hypoparathyroidism-retardation-dysmorphism syndrome and kenny-caffey syndrome. Among its related pathways are Transport to the Golgi and subsequent modification and Cytoskeletal Signaling. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA3C.
UniProtKB/Swiss-Prot for TUBA1B Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).