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Aliases for TUBA1B Gene

Aliases for TUBA1B Gene

  • Tubulin Alpha 1b 2 3 5
  • Tubulin Alpha-Ubiquitous Chain 3 4
  • Alpha-Tubulin Ubiquitous 3 4
  • Tubulin K-Alpha-1 3 4
  • Tubulin, Alpha, Ubiquitous 3
  • Tubulin, Alpha 1b 3
  • Alpha Tubulin 3
  • Ubiquitous 2
  • K-ALPHA-1 3
  • Tubulin 2
  • Alpha 2

External Ids for TUBA1B Gene

Previous GeneCards Identifiers for TUBA1B Gene

  • GC12M047809
  • GC12M049523
  • GC12M046552

Summaries for TUBA1B Gene

GeneCards Summary for TUBA1B Gene

TUBA1B (Tubulin Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include distal hereditary motor neuropathy, type ii and pachygyria. Among its related pathways are Transport to the Golgi and subsequent modification and Development Slit-Robo signaling. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA4B.

UniProtKB/Swiss-Prot for TUBA1B Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Tocris Summary for TUBA1B Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBA1B Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA1B Gene

Genomics for TUBA1B Gene

Regulatory Elements for TUBA1B Gene

Promoters for TUBA1B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TUBA1B on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBA1B Gene

Chromosome:
12
Start:
49,127,782 bp from pter
End:
49,131,521 bp from pter
Size:
3,740 bases
Orientation:
Minus strand

Genomic View for TUBA1B Gene

Genes around TUBA1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBA1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBA1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA1B Gene

Proteins for TUBA1B Gene

  • Protein details for TUBA1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68363-TBA1B_HUMAN
    Recommended name:
    Tubulin alpha-1B chain
    Protein Accession:
    P68363
    Secondary Accessions:
    • P04687
    • P05209
    • Q27I68
    • Q8WU19

    Protein attributes for TUBA1B Gene

    Size:
    451 amino acids
    Molecular mass:
    50152 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Three dimensional structures from OCA and Proteopedia for TUBA1B Gene

    Alternative splice isoforms for TUBA1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TUBA1B Gene

Proteomics data for TUBA1B Gene at MOPED

Post-translational modifications for TUBA1B Gene

  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Ubiquitination at Lys 326 and Lys 370
  • Modification sites at PhosphoSitePlus

Other Protein References for TUBA1B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TUBA1B (TUBA1B)

No data available for DME Specific Peptides for TUBA1B Gene

Domains & Families for TUBA1B Gene

Gene Families for TUBA1B Gene

Suggested Antigen Peptide Sequences for TUBA1B Gene

Graphical View of Domain Structure for InterPro Entry

P68363

UniProtKB/Swiss-Prot:

TBA1B_HUMAN :
  • Belongs to the tubulin family.
Family:
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA1B: view

Function for TUBA1B Gene

Molecular function for TUBA1B Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Gene Ontology (GO) - Molecular Function for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IEA,IPI 11698390
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with TUBA1B: view
genes like me logo Genes that share phenotypes with TUBA1B: view

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBA1B Gene

Localization for TUBA1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA1B Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TUBA1B Gene COMPARTMENTS Subcellular localization image for TUBA1B gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 3
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TUBA1B Gene

Pathways & Interactions for TUBA1B Gene

genes like me logo Genes that share pathways with TUBA1B: view

SIGNOR curated interactions for TUBA1B Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TUBA1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IEA --
GO:0007017 microtubule-based process IEA,TAS 12090300
GO:0030705 cytoskeleton-dependent intracellular transport TAS 12090300
GO:0044267 cellular protein metabolic process TAS --
GO:0051084 de novo posttranslational protein folding TAS --
genes like me logo Genes that share ontologies with TUBA1B: view

Drugs & Compounds for TUBA1B Gene

(36) Drugs for TUBA1B Gene - From: Novoseek, DrugBank, Tocris, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 104
Taxol Approved August 1997 Pharma Agonist Promotes assembly and inhibits disassembly of microtubules 0
Epothilone B Experimental, Investigational Pharma Target 67
Nocodazole Experimental Pharma Tubulin production inhibitor,anti-neoplastic agent, Microtubule inhibitor 0
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Experimental Pharma Target 0

(34) Additional Compounds for TUBA1B Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Vinblastine sulfate
143-67-9
Vincristine sulfate
2068-78-2

(5) Tocris Compounds for TUBA1B Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Nocodazole Microtubule inhibitor 31430-18-9
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
Vincristine sulfate Disrupts microtubules 2068-78-2
genes like me logo Genes that share compounds with TUBA1B: view

Transcripts for TUBA1B Gene

Unigene Clusters for TUBA1B Gene

Tubulin, alpha 1b:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA1B Gene

No ASD Table

Relevant External Links for TUBA1B Gene

GeneLoc Exon Structure for
TUBA1B
ECgene alternative splicing isoforms for
TUBA1B

Expression for TUBA1B Gene

mRNA expression in normal human tissues for TUBA1B Gene

Protein differential expression in normal tissues from HIPED for TUBA1B Gene

This gene is overexpressed in Bone (29.6) and Brain (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TUBA1B Gene



SOURCE GeneReport for Unigene cluster for TUBA1B Gene Hs.524390

genes like me logo Genes that share expression patterns with TUBA1B: view

Protein tissue co-expression partners for TUBA1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TUBA1B Gene

Orthologs for TUBA1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TUBA1B 35
  • 95.64 (n)
  • 100 (a)
TUBA1B 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TUBA1B 36
  • 100 (a)
OneToOne
TUBA1B 35
  • 99.41 (n)
  • 99.78 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Tuba1b 36
  • 100 (a)
OneToOne
Tuba1b 16
Tuba1b 35
  • 94.38 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia TUBA1B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 100 (a)
ManyToMany
LOC610636 35
  • 85.37 (n)
  • 98.67 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 57 (a)
OneToMany
TUBAL3 35
  • 81.85 (n)
  • 89.75 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 100 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tuba4a 35
  • 87.21 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii tuba2 36
  • 98 (a)
ManyToMany
tuba2 35
  • 82.63 (n)
  • 98.23 (a)
-- 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.460 35
worm
(Caenorhabditis elegans)
Secernentea Y19D2B.1 36
  • 82 (a)
OneToMany
tba-9 35
  • 71.99 (n)
  • 87.21 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7613 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
Species with no ortholog for TUBA1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBA1B Gene

ENSEMBL:
Gene Tree for TUBA1B (if available)
TreeFam:
Gene Tree for TUBA1B (if available)

Paralogs for TUBA1B Gene

Paralogs for TUBA1B Gene

Pseudogenes.org Pseudogenes for TUBA1B Gene

genes like me logo Genes that share paralogs with TUBA1B: view

Variants for TUBA1B Gene

Sequence variations from dbSNP and Humsavar for TUBA1B Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2753 -- 49,127,889(-) ACAGA(C/T)GTTAA utr-variant-3-prime
rs706799 -- 49,128,246(-) ATCAA(C/T)TACCA reference, synonymous-codon
rs755231 -- 49,129,028(+) CATAT(C/T)TCACT intron-variant
rs1057072 -- 49,129,266(-) GACCT(C/T)GTGTT reference, synonymous-codon
rs1057548 -- 49,128,822(+) TTGGA(C/T)TTCTT reference, synonymous-codon

Variation tolerance for TUBA1B Gene

Residual Variation Intolerance Score: 47.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBA1B Gene

HapMap Linkage Disequilibrium report
TUBA1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TUBA1B Gene

Disorders for TUBA1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for TUBA1B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
distal hereditary motor neuropathy, type ii
  • spinal muscular atrophy, jerash type
pachygyria
  • broad gyri of cerebrum
congenital nervous system abnormality
  • congenital neurologic anomaly
physical disorder
  • physical illness
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TUBA1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TUBA1B
genes like me logo Genes that share disorders with TUBA1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TUBA1B Gene

Publications for TUBA1B Gene

  1. Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. (PMID: 6646120) Cowan N.J. … Cleveland D.W. (Mol. Cell. Biol. 1983) 2 3 4 67
  2. Anti-leukaemic effects of two extract types of Lactuca sativa correlate with the activation of Chk2, induction of p21, downregulation of cyclin D1 and acetylation of alpha-tubulin. (PMID: 20204303) Gridling M. … Krupitza G. (Oncol. Rep. 2010) 3 23
  3. ADP-ribosylation factor like 7 (ARL7) interacts with alpha-tubulin and modulates intracellular vesicular transport. (PMID: 19409876) Wei S.M. … Cai J.T. (Biochem. Biophys. Res. Commun. 2009) 3 23
  4. Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells. (PMID: 12054644) Banerjee A. (Biochem. Biophys. Res. Commun. 2002) 2 3
  5. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. (PMID: 11146551) Germani A. … Calvo F. (Oncogene 2000) 3 23

Products for TUBA1B Gene

Sources for TUBA1B Gene

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