Aliases for TUBA1B Gene
External Ids for TUBA1B Gene
Previous GeneCards Identifiers for TUBA1B Gene
GeneCards Summary for TUBA1B Gene
TUBA1B (Tubulin Alpha 1b) is a Protein Coding gene. Diseases associated with TUBA1B include Hypoparathyroidism-Retardation-Dysmorphism Syndrome and Distal Hereditary Motor Neuropathy, Type Ii. Among its related pathways are Signaling in Gap Junctions and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA1A.
UniProtKB/Swiss-Prot for TUBA1B Gene
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).