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Aliases for TUBA1A Gene

Aliases for TUBA1A Gene

  • Tubulin Alpha 1a 2 3 5
  • Tubulin Alpha-3 Chain 3 4
  • Tubulin B-Alpha-1 3 4
  • TUBA3 3 4
  • Tubulin, Alpha, Brain-Specific 3
  • Tubulin, Alpha 1a 3
  • Alpha-Tubulin 3 4
  • Brain-Specific 2
  • Hum-A-Tub1 3
  • Hum-A-Tub2 3
  • B-ALPHA-1 3
  • Tubulin 2
  • Alpha 2
  • LIS3 3

External Ids for TUBA1A Gene

Previous GeneCards Identifiers for TUBA1A Gene

  • GC12M047865
  • GC12M049578
  • GC12M046609

Summaries for TUBA1A Gene

Entrez Gene Summary for TUBA1A Gene

  • Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in this gene cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for TUBA1A Gene

TUBA1A (Tubulin Alpha 1a) is a Protein Coding gene. Diseases associated with TUBA1A include Lissencephaly 3 and Lissencephaly Due To Tuba1a Mutation. Among its related pathways are Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is TUBA4B.

UniProtKB/Swiss-Prot for TUBA1A Gene

  • Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Tocris Summary for TUBA1A Gene

  • Microtubules are cylindrical tubes of 20-25 nm in diameter. They are composed of protofilaments which are in turn composed of alpha- and beta-tubulin polymers. Each microtubule is polarized; at one end alpha-subunits are exposed (-) and at the other, beta-subunits are exposed (+).

Gene Wiki entry for TUBA1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUBA1A Gene

Genomics for TUBA1A Gene

Regulatory Elements for TUBA1A Gene

Enhancers for TUBA1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TUBA1A on UCSC Golden Path with GeneCards custom track

Promoters for TUBA1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TUBA1A on UCSC Golden Path with GeneCards custom track

Genomic Location for TUBA1A Gene

49,184,795 bp from pter
49,189,324 bp from pter
4,530 bases
Minus strand

Genomic View for TUBA1A Gene

Genes around TUBA1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUBA1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUBA1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUBA1A Gene

Proteins for TUBA1A Gene

  • Protein details for TUBA1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tubulin alpha-1A chain
    Protein Accession:
    Secondary Accessions:
    • A8K0B8
    • G3V1U9
    • P04687
    • P05209

    Protein attributes for TUBA1A Gene

    451 amino acids
    Molecular mass:
    50136 Da
    Quaternary structure:
    • Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

    Alternative splice isoforms for TUBA1A Gene


neXtProt entry for TUBA1A Gene

Proteomics data for TUBA1A Gene at MOPED

Post-translational modifications for TUBA1A Gene

  • Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling (By similarity).
  • Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
  • Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TUBA1A Gene

Domains & Families for TUBA1A Gene

Gene Families for TUBA1A Gene

Suggested Antigen Peptide Sequences for TUBA1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tubulin family.
  • Belongs to the tubulin family.
genes like me logo Genes that share domains with TUBA1A: view

Function for TUBA1A Gene

Molecular function for TUBA1A Gene

UniProtKB/Swiss-Prot Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Gene Ontology (GO) - Molecular Function for TUBA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005200 structural constituent of cytoskeleton IEA --
genes like me logo Genes that share ontologies with TUBA1A: view
genes like me logo Genes that share phenotypes with TUBA1A: view

Human Phenotype Ontology for TUBA1A Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TUBA1A Gene

Localization for TUBA1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUBA1A Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

Jensen Localization Image for TUBA1A Gene COMPARTMENTS Subcellular localization image for TUBA1A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
extracellular 5
nucleus 5
plasma membrane 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TUBA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036464 cytoplasmic ribonucleoprotein granule IDA 15121898
genes like me logo Genes that share ontologies with TUBA1A: view

Pathways & Interactions for TUBA1A Gene

genes like me logo Genes that share pathways with TUBA1A: view

SIGNOR curated interactions for TUBA1A Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TUBA1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006996 organelle organization TAS --
GO:0007017 microtubule-based process IEA,TAS 12090300
GO:0030705 cytoskeleton-dependent intracellular transport TAS 12090300
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with TUBA1A: view

Drugs & Compounds for TUBA1A Gene

(21) Drugs for TUBA1A Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Mebendazole Approved Pharma binder, Target, inhibitor 23
Albendazole Approved Pharma Target, inhibitor 74
Vinblastine Approved Pharma Target, adduct 396
Colchicine Approved Pharma Antagonist Tubulin Inhibitor, Inhibitor of tubulin 105
Cabazitaxel Approved Pharma 0

(2) Additional Compounds for TUBA1A Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Vinblastine sulfate
Vincristine sulfate

(5) Tocris Compounds for TUBA1A Gene

Compound Action Cas Number
Colchicine Inhibitor of tubulin 64-86-8
Nocodazole Microtubule inhibitor 31430-18-9
Taxol Promotes assembly and inhibits disassembly of microtubules 33069-62-4
Vinblastine sulfate Disrupts microtubules 143-67-9
Vincristine sulfate Disrupts microtubules 2068-78-2

(11) ApexBio Compounds for TUBA1A Gene

Compound Action Cas Number
Cabazitaxel 183133-96-2
CK-636 Arp2/3 complex inhibitor 442632-72-6
Colchicine Tubulin Inhibitor 64-86-8
CYT997 (Lexibulin) 917111-44-5
Epothilone A Microtubule stabilizing macrolide 152044-53-6
Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium 168555-66-6
Griseofulvin 126-07-8
INH6 1001753-24-7
MPC 6827 hydrochloride Potent microtubule inhibitor 917369-31-4
Plinabulin (NPI-2358) Tumor cell lines inhibitor 714272-27-2
Vinflunine Tartrate 1201898-17-0
genes like me logo Genes that share compounds with TUBA1A: view

Transcripts for TUBA1A Gene

Unigene Clusters for TUBA1A Gene

Tubulin, alpha 1a:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TUBA1A Gene

No ASD Table

Relevant External Links for TUBA1A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TUBA1A Gene

mRNA expression in normal human tissues for TUBA1A Gene

mRNA differential expression in normal tissues according to GTEx for TUBA1A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0).

Protein differential expression in normal tissues from HIPED for TUBA1A Gene

This gene is overexpressed in Brain (14.9), Adipocyte (12.9), and Breast (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TUBA1A Gene

SOURCE GeneReport for Unigene cluster for TUBA1A Gene Hs.654422

mRNA Expression by UniProt/SwissProt for TUBA1A Gene

Tissue specificity: Expressed at a high level in fetal brain.
genes like me logo Genes that share expression patterns with TUBA1A: view

Protein tissue co-expression partners for TUBA1A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TUBA1A Gene

Orthologs for TUBA1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TUBA1A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TUBA1A 35
  • 95.71 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia TUBA1A 35
  • 95.34 (n)
  • 100 (a)
  • 79 (a)
(Mus musculus)
Mammalia Tuba1a 35
  • 93.64 (n)
  • 100 (a)
Tuba1a 16
Tuba1a 36
  • 100 (a)
(Pan troglodytes)
Mammalia TUBA1A 35
  • 99.19 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tuba1a 35
  • 94.01 (n)
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia TUBA1A 36
  • 68 (a)
(Gallus gallus)
Aves TUBA3E 35
  • 80.66 (n)
  • 95.56 (a)
-- 36
  • 57 (a)
(Anolis carolinensis)
Reptilia TUBA1A 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tuba1b 35
  • 87.8 (n)
  • 100 (a)
(Danio rerio)
Actinopterygii tuba1l2 35
  • 85.66 (n)
  • 99.78 (a)
tuba1a 36
  • 100 (a)
tuba1c 36
  • 100 (a)
(Caenorhabditis elegans)
Secernentea tba-5 35
  • 69.48 (n)
  • 84.74 (a)
Y19D2B.1 36
  • 82 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TUB3 38
(Hordeum vulgare)
Liliopsida Hv.4030 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2516 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
-- 36
  • 53 (a)
Species with no ortholog for TUBA1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUBA1A Gene

Gene Tree for TUBA1A (if available)
Gene Tree for TUBA1A (if available)

Paralogs for TUBA1A Gene

Paralogs for TUBA1A Gene

genes like me logo Genes that share paralogs with TUBA1A: view

Variants for TUBA1A Gene

Sequence variations from dbSNP and Humsavar for TUBA1A Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1065730 - 49,185,027(-) AGGAA(A/G)AAGGA reference, missense
VAR_039332 Lissencephaly 3 (LIS3)
VAR_039333 Lissencephaly 3 (LIS3)
VAR_039334 Lissencephaly 3 (LIS3)
VAR_039335 Lissencephaly 3 (LIS3)

Variation tolerance for TUBA1A Gene

Residual Variation Intolerance Score: 77.5% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TUBA1A Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TUBA1A Gene

Disorders for TUBA1A Gene

MalaCards: The human disease database

(10) MalaCards diseases for TUBA1A Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
lissencephaly 3
  • lis3
lissencephaly due to tuba1a mutation
  • broad gyri of cerebrum
- elite association - COSMIC cancer census association via MalaCards


  • Lissencephaly 3 (LIS3) [MIM:611603]: A classic type lissencephaly associated with psychomotor retardation and seizures. Features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem. {ECO:0000269 PubMed:17584854}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TUBA1A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TUBA1A: view

No data available for Genatlas for TUBA1A Gene

Publications for TUBA1A Gene

  1. Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site. (PMID: 11504633) Crabtree D.V. … Adler A.J. (Bioorg. Med. Chem. 2001) 2 3 4 67
  2. Potent inhibition of tubulin polymerisation and proliferation of paclitaxel-resistant 1A9PTX22 human ovarian cancer cells by albendazole. (PMID: 19846910) Chu S.W. … Pourgholami M.H. (Anticancer Res. 2009) 25 26
  3. Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude. (PMID: 17662615) Wampande E.M. … Lubega G.W. (Protein Expr. Purif. 2007) 25 26
  4. How do microtubule-targeted drugs work? An overview. (PMID: 18220533) Jordan M.A. … Kamath K. (Curr Cancer Drug Targets 2007) 25 26
  5. Human fibrillarin forms a sub-complex with splicing factor 2- associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes. (PMID: 14583623) Yanagida M. … Takahashi N. (J. Biol. Chem. 2004) 3 23

Products for TUBA1A Gene

Sources for TUBA1A Gene